Web Desc
The Cellular Biology of Atherosclerosis
Organizer(s): Ira Tabas and Elizabeth Nabel
Date: January 22 - 27, 2005
Location: Keystone Resort, Keystone, CO, USA
Part of the Translational Medicine Series, Supported by Pfizer Global Research and Development
Summary of Meeting:
Atherosclerotic vascular disease, the leading cause of death in the industrialized world, begins when lipoproteins retained in the arterial wall provoke a series of cellular reactions involving macrophages, endothelial cells, smooth muscle cells, and immune cells. The lesion is propagated through a series of complex cell-cell and cell-lipid interactions, leading to inflammation, extracellular matrix alterations, and necrosis. These events, in turn, promote plaque disruption, acute thrombosis, and sudden vascular occlusion. The cellular processes of atherogenesis represent key therapeutic targets, but successful strategies will require a thorough understanding of the cellular and molecular mechanisms involved. In this meeting, leading cellular and molecular biologists will discuss the latest advances in these areas of research. A major goal is to spawn new interactions between researchers focused on atherogenesis per se and those with expert knowledge in cell biological areas that warrant greater representation in atherosclerosis research.
Discounted Abstract Deadline: September 22 2004
Discounted Registration Deadline: November 22 2004
We gratefully acknowledge additional support for this conference from:
American Heart AssociationNovartis Institutes for BioMedical ResearchPfizer Global Research & Development
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Exelixis, Inc.

Pfizer Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13-HL079776-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Saturday, January 22 | 3:00PM - 7:30PM
Registration
Room: Shavano Peak Foyer


Saturday, January 22 | 6:30PM - 7:30PM
Refreshments
Room: Shavano Peak Foyer


Saturday, January 22 | 7:30PM - 8:30PM
Keynote Address
Room: Red Cloud/Shavano

Speaker 1 of 1
James E. Rothman, Yale University School of Medicine, USA
Principles of Membrane Fusion

Sunday, January 23 | 7:00AM - 8:00AM
Breakfast
Room: Crestone Peak


Sunday, January 23 | 8:00AM - 11:00AM
Endothelial Function and Atherosclerosis
Room: Red Cloud/Shavano

Speaker 1 of 5
* Bradford C. Berk, University of Rochester Medical Center, USA
Atheroprotective Mechanisms of Steady Laminar Blood Flow

Sunday, January 23 | 8:00AM - 11:00AM
Endothelial Function and Atherosclerosis
Room: Red Cloud/Shavano

Speaker 2 of 5
David Harrison, Emory University, USA
Oxidant Stress and Vascular Function

Sunday, January 23 | 8:00AM - 11:00AM
Endothelial Function and Atherosclerosis
Room: Red Cloud/Shavano

Speaker 3 of 5
Hanjoong Jo, Emory University, USA
Short Talk: Bone Morphogenic Protein 4 Produced in Endothelial Cells by Oscillatory Shear Stress Induces Monocyte Adhesion by Stimulating Reactive Oxygen Species Production from a nox1-Based NADPH Oxidase

Sunday, January 23 | 8:00AM - 11:00AM
Endothelial Function and Atherosclerosis
Room: Red Cloud/Shavano

Speaker 4 of 5
Michael E. Mendelsohn, USA
Molecular Mechanisms Regulating Vascular Smooth Muscle Cell Tone and Blood Pressure

Sunday, January 23 | 8:00AM - 11:00AM
Endothelial Function and Atherosclerosis
Room: Red Cloud/Shavano

Speaker 5 of 5
Philip Marsden, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Univ of Toronto, Canada
Short Talk: The Cell-Specific Expression of Endothelial Nitric Oxide Synthase (eNOS): A Role for Chromatin-Based Mechanisms

Sunday, January 23 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Sunday, January 23 | 11:15AM - 1:00PM
Poster Setup
Room: Crestone Peak


Sunday, January 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Crestone Peak


Sunday, January 23 | 2:00PM - 4:00PM
Workshop 1: Novel Molecular Targets in Atherosclerosis and I
dentification through Genomic and Proteomic Approaches
Room: Red Cloud/Shavano

Speaker 1 of 7
* Karen K. Hirschi, Yale University, USA

Sunday, January 23 | 2:00PM - 4:00PM
Workshop 1: Novel Molecular Targets in Atherosclerosis and I
dentification through Genomic and Proteomic Approaches
Room: Red Cloud/Shavano

Speaker 2 of 7
Willmar D. Patino, NHLBI, National Institutes of Health, USA
FOS as a Novel Marker of Atherosclerosis

Sunday, January 23 | 2:00PM - 4:00PM
Workshop 1: Novel Molecular Targets in Atherosclerosis and I
dentification through Genomic and Proteomic Approaches
Room: Red Cloud/Shavano

Speaker 3 of 7
Paul Kroeger, Abbott Laboratories, USA
Effects of 1alpha,25-dihydroxyvitamin D3 on Gene Expression Profiling in Human Coronary Artery Smooth Muscle Cells

Sunday, January 23 | 2:00PM - 4:00PM
Workshop 1: Novel Molecular Targets in Atherosclerosis and I
dentification through Genomic and Proteomic Approaches
Room: Red Cloud/Shavano

Speaker 4 of 7
Santhi K. Ganesh, NHLBI, National Institutes of Health, USA
Dissection of a Complex Vascular Disease: The CardioGene Study - Genomics of In-Stent Restenosis

Sunday, January 23 | 2:00PM - 4:00PM
Workshop 1: Novel Molecular Targets in Atherosclerosis and I
dentification through Genomic and Proteomic Approaches
Room: Red Cloud/Shavano

Speaker 5 of 7
Jan H. N. Lindeman, Leids Universitair Medisch Centre, Netherlands
Cathepsin K and S are the Principal Proteases in Stable (AAA) and Ruptured Aortic Abdominal Aneurysm (AAAAA)

Sunday, January 23 | 2:00PM - 4:00PM
Workshop 1: Novel Molecular Targets in Atherosclerosis and I
dentification through Genomic and Proteomic Approaches
Room: Red Cloud/Shavano

Speaker 6 of 7
Carlie J. M. de Vries, University of Amsterdam, Netherlands
TR3 Nuclear Receptor is a Novel Target for Intervention in Smooth Muscle Cell Hyperplasia

Sunday, January 23 | 2:00PM - 4:00PM
Workshop 1: Novel Molecular Targets in Atherosclerosis and I
dentification through Genomic and Proteomic Approaches
Room: Red Cloud/Shavano

Speaker 7 of 7
Daniel Eefting, TNO Prevention and Health, Netherlands
Blocking of the MCP-1/CCR2 Pathway Inhibits Intimal Hyperplasia in Vein Grafts

Sunday, January 23 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Sunday, January 23 | 5:00PM - 7:15PM
The Entry and Differentiation of Monocytes in Nascent Athero
sclerotic Lesions

Room: Red Cloud/Shavano

Speaker 1 of 5
* Klaus Ley, La Jolla Institute for Allergy and Immunology, USA
Arrest Chemokines and Monocyte Recruitment to Atherosclerosic Lesions

Sunday, January 23 | 5:00PM - 7:15PM
The Entry and Differentiation of Monocytes in Nascent Athero
sclerotic Lesions

Room: Red Cloud/Shavano

Speaker 2 of 5
Myron I. Cybulsky, University of Toronto, Canada
Leukocytes, Inflammation and the Initiation of Atherosclerosis

Sunday, January 23 | 5:00PM - 7:15PM
The Entry and Differentiation of Monocytes in Nascent Athero
sclerotic Lesions

Room: Red Cloud/Shavano

Speaker 3 of 5
Ralph Gareus, EMBL Program On Mouse Biology, Italy
Short Talk: The Role of Endothelial NF-kappaB in Atherosclerosis

Sunday, January 23 | 5:00PM - 7:15PM
The Entry and Differentiation of Monocytes in Nascent Athero
sclerotic Lesions

Room: Red Cloud/Shavano

Speaker 4 of 5
William A. Muller, Northwestern University, USA
Cellular and Molecular Control of Transendothelial Migration

Sunday, January 23 | 5:00PM - 7:15PM
The Entry and Differentiation of Monocytes in Nascent Athero
sclerotic Lesions

Room: Red Cloud/Shavano

Speaker 5 of 5
Aron Chakera, University of Oxford, UK
Short Talk: Duffy Antigen/Receptor for Chemokines (DARC): A Novel Anti-Inflammatory/Anti-Chemokine Approach to Atherosclerosis

Sunday, January 23 | 7:15PM - 8:15PM
Social Hour
Room: Crestone Peak


Sunday, January 23 | 7:30PM - 10:00PM
Poster Session 1
Room: Crestone Peak


Monday, January 24 | 7:00AM - 8:00AM
Breakfast
Room: Crestone Peak


Monday, January 24 | 8:00AM - 11:15AM
The Role of Macrophages in Atherosclerosis
Room: Red Cloud/Shavano

Speaker 1 of 6
* Christopher K. Glass, University of California, San Diego, USA
Regulation of Macrophage Foam Cell Formation and Development of Atherosclerosis by PPARs

Monday, January 24 | 8:00AM - 11:15AM
The Role of Macrophages in Atherosclerosis
Room: Red Cloud/Shavano

Speaker 2 of 6
Mason W. Freeman, Massachusetts General Hospital, USA
Macrophage Inflammatory Processes and Atherosclerosis


Monday, January 24 | 8:00AM - 11:15AM
The Role of Macrophages in Atherosclerosis
Room: Red Cloud/Shavano

Speaker 3 of 6
Yury I. Miller, University of California, San Diego, USA
Short Talk: Early Forms of Oxidized LDL Augment Cytokine
Responses to LPS via a PI3K/Akt Mechanism


Monday, January 24 | 8:00AM - 11:15AM
The Role of Macrophages in Atherosclerosis
Room: Red Cloud/Shavano

Speaker 4 of 6
Peter Tontonoz, University of California, Los Angeles, USA
Nuclear Receptors at the Crossroads of Lipid Metabolism and Inflammation

Monday, January 24 | 8:00AM - 11:15AM
The Role of Macrophages in Atherosclerosis
Room: Red Cloud/Shavano

Speaker 5 of 6
Robert Clive Landis, University of West Indies, Barbados
Short Talk: Impaired Anti-Inflammatory Signaling following Scavenging
of Haptoglobin2-2:Hemoglobin Complexes by CD163


Monday, January 24 | 8:00AM - 11:15AM
The Role of Macrophages in Atherosclerosis
Room: Red Cloud/Shavano

Speaker 6 of 6
Ira Tabas, Columbia University, USA
Signal Transduction in Cholesterol-Loaded Macrophages

Monday, January 24 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Monday, January 24 | 11:15AM - 1:00PM
Poster Setup
Room: Crestone Peak


Monday, January 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Crestone Peak


Monday, January 24 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Monday, January 24 | 5:00PM - 7:00PM
The Immune System in Atheroslcerosis
Room: Red Cloud/Shavano

Speaker 1 of 4
* Göran K. Hansson, Karolinska University Hospital, Sweden
Role of Adaptive Immunity in Atherosclerosis

Monday, January 24 | 5:00PM - 7:00PM
The Immune System in Atheroslcerosis
Room: Red Cloud/Shavano

Speaker 2 of 4
Joseph L. Witztum, University of California, San Diego, USA
The Role of Innate Immunity in Atherosclerosis

Monday, January 24 | 5:00PM - 7:00PM
The Immune System in Atheroslcerosis
Room: Red Cloud/Shavano

Speaker 3 of 4
Elena Galkina, Eastern Virginia Medical School, USA
Short Talk: Constitutive Trafficking of Lymphocytes into the Murine Aorta

Monday, January 24 | 5:00PM - 7:00PM
The Immune System in Atheroslcerosis
Room: Red Cloud/Shavano

Speaker 4 of 4
Andrew H. Lichtman, Brigham and Women's Hospital, USA
Regulation of T Cell Responses in Atherosclerosis

Monday, January 24 | 7:00PM - 8:00PM
Social Hour
Room: Crestone Peak


Monday, January 24 | 7:30PM - 10:00PM
Poster Session 2
Room: Crestone Peak


Tuesday, January 25 | 7:00AM - 8:00AM
Breakfast
Room: Crestone Peak


Tuesday, January 25 | 8:00AM - 11:15AM
Smooth Muscle Cell Proliferation, Differentiation, and Pheno
typic Modulation

Room: Red Cloud/Shavano

Speaker 1 of 6
Brant M. Weinstein, NICHD, National Institutes of Health, USA
Building Vascular Networks during Development

Tuesday, January 25 | 8:00AM - 11:15AM
Smooth Muscle Cell Proliferation, Differentiation, and Pheno
typic Modulation

Room: Red Cloud/Shavano

Speaker 2 of 6
Karen K. Hirschi, Yale University, USA
Role of Gap Junction Communication in Mural Cell Differentiation

Tuesday, January 25 | 8:00AM - 11:15AM
Smooth Muscle Cell Proliferation, Differentiation, and Pheno
typic Modulation

Room: Red Cloud/Shavano

Speaker 3 of 6
Nicola Ferri, University of Milan, Italy
Short Talk: Pericellular Regulation of Vascular Smooth Muscle Remodeling: MMP2-Mediated Cleavage of the Novel MMP Inhibitor RECK

Tuesday, January 25 | 8:00AM - 11:15AM
Smooth Muscle Cell Proliferation, Differentiation, and Pheno
typic Modulation

Room: Red Cloud/Shavano

Speaker 4 of 6
Gary K. Owens, University of Virginia, USA
Molecular Regulation of Smooth Differentiation in Development and Disease

Tuesday, January 25 | 8:00AM - 11:15AM
Smooth Muscle Cell Proliferation, Differentiation, and Pheno
typic Modulation

Room: Red Cloud/Shavano

Speaker 5 of 6
* Elizabeth G. Nabel, Brigham & Womens Hospital, USA
Cell Cycle, Vascular Proliferation, and Inflammation

Tuesday, January 25 | 8:00AM - 11:15AM
Smooth Muscle Cell Proliferation, Differentiation, and Pheno
typic Modulation

Room: Red Cloud/Shavano

Speaker 6 of 6
Debbie Beasley, Tufts New England Medical Center, USA
Short Talk: Toll-like Receptor 2 is Expressed in Vascular Smooth Muscle Cells and Mediates C. pneumoniae-Induced Chemokine Release

Tuesday, January 25 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Tuesday, January 25 | 11:15AM - 1:00PM
Poster Setup
Room: Crestone Peak


Tuesday, January 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Crestone Peak


Tuesday, January 25 | 2:00PM - 4:00PM
Workshop 2: New Insights into the Pathobiology of the Macrop
hage Foam Cell
Room: Red Cloud/Shavano

Speaker 1 of 8
* Mason W. Freeman, Massachusetts General Hospital, USA

Tuesday, January 25 | 2:00PM - 4:00PM
Workshop 2: New Insights into the Pathobiology of the Macrop
hage Foam Cell
Room: Red Cloud/Shavano

Speaker 2 of 8
Howard S. Kruth, NHLBI, National Institutes of Health, USA
Macrophage Foam Cell Formation without LDL Modification or Receptors

Tuesday, January 25 | 2:00PM - 4:00PM
Workshop 2: New Insights into the Pathobiology of the Macrop
hage Foam Cell
Room: Red Cloud/Shavano

Speaker 3 of 8
Valerie Sier-Ferreira, Academic Medical Center, Netherlands
Prevention of NF-kappaB Activation in Macrophages Impairs Foam Cells Formation

Tuesday, January 25 | 2:00PM - 4:00PM
Workshop 2: New Insights into the Pathobiology of the Macrop
hage Foam Cell
Room: Red Cloud/Shavano

Speaker 4 of 8
Marta Scatena, University of Washington, USA
Osteopontin as a Survival Factor for Macrophages

Tuesday, January 25 | 2:00PM - 4:00PM
Workshop 2: New Insights into the Pathobiology of the Macrop
hage Foam Cell
Room: Red Cloud/Shavano

Speaker 5 of 8
Tracie A. Seimon, Columbia University, USA
Two-Step Mechanism of Cholesterol-Induced Macrophage Apoptosis:
Apoptosis Requires a Priming Step Mediated by p38 MAPK induced UPR activation, and a Trigger Step Mediated by the Engagement of Type A Scavenger Receptor


Tuesday, January 25 | 2:00PM - 4:00PM
Workshop 2: New Insights into the Pathobiology of the Macrop
hage Foam Cell
Room: Red Cloud/Shavano

Speaker 6 of 8
Richard C. Austin, McMaster University, Canada
Activation of the Unfolded Protein Response (UPR) During Atherosclerotic Lesion Growth in ApoE-Deficient Mice

Tuesday, January 25 | 2:00PM - 4:00PM
Workshop 2: New Insights into the Pathobiology of the Macrop
hage Foam Cell
Room: Red Cloud/Shavano

Speaker 7 of 8
Lianne S.M. Boesten, TNO-PG, Leiden University Medical Center, Netherlands
Retinoblastoma Deficiency in Macrophages Increases Atherosclerosis in ApoE-Deficient Mice

Tuesday, January 25 | 2:00PM - 4:00PM
Workshop 2: New Insights into the Pathobiology of the Macrop
hage Foam Cell
Room: Red Cloud/Shavano

Speaker 8 of 8
Elaine W. Raines, University of Washington, USA
Macrophage Expression of Active MMP-9 is Sufficient to Induce Plaque Rupture in APOE-/- Mice

Tuesday, January 25 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Tuesday, January 25 | 5:00PM - 7:00PM
Cellular Calcium Metabolism in Atherosclerotic Lesions
Room: Red Cloud/Shavano

Speaker 1 of 3
* Linda L. Demer, University of California, Los Angeles, USA
The Role of Vascular Stem Cells in Arterial Calcification


Tuesday, January 25 | 5:00PM - 7:00PM
Cellular Calcium Metabolism in Atherosclerotic Lesions
Room: Red Cloud/Shavano

Speaker 2 of 3
Catherine M. Shanahan, University of Cambridge, UK
Initiators, Inhibitors and Vesicles in Arterial Calcification

Tuesday, January 25 | 5:00PM - 7:00PM
Cellular Calcium Metabolism in Atherosclerotic Lesions
Room: Red Cloud/Shavano

Speaker 3 of 3
Cecilia M. Giachelli, University of Washington, USA
Osteopontin and Atherosclerosis: Linking Inflammation and Matrix Mineralization

Tuesday, January 25 | 7:00PM - 8:00PM
Social Hour
Room: Crestone Peak


Tuesday, January 25 | 7:30PM - 10:00PM
Poster Session 3
Room: Crestone Peak


Wednesday, January 26 | 7:00AM - 8:00AM
Breakfast
Room: Crestone Peak


Wednesday, January 26 | 8:00AM - 11:15AM
Cholesterol Efflux and Nuclear Receptors
Room: Red Cloud/Shavano

Speaker 1 of 6
Richard A. Heyman, ORIC Pharmaceuticals, USA
Orphan Nuclear Receptors as Targets for Cardiovascular Disease

Wednesday, January 26 | 8:00AM - 11:15AM
Cholesterol Efflux and Nuclear Receptors
Room: Red Cloud/Shavano

Speaker 2 of 6
* Alan R. Tall, Columbia University, USA
Role of ABCG1 and ABCG4 in Cellular Cholesterol Efflux to HDL

Wednesday, January 26 | 8:00AM - 11:15AM
Cholesterol Efflux and Nuclear Receptors
Room: Red Cloud/Shavano

Speaker 3 of 6
Xiaohui Zha, Ottawa Hospital Research Institute, Canada
Intracellular Vesicular Trafficking in Cholesterol Efflux Pathways

Wednesday, January 26 | 8:00AM - 11:15AM
Cholesterol Efflux and Nuclear Receptors
Room: Red Cloud/Shavano

Speaker 4 of 6
Omar L. Francone, Pfizer Inc., USA
The Role of ABCA1 in Cholesterol Trafficking


Wednesday, January 26 | 8:00AM - 11:15AM
Cholesterol Efflux and Nuclear Receptors
Room: Red Cloud/Shavano

Speaker 5 of 6
Theo J. C. Van Berkel, University of Leiden, Netherlands
Short Talk: Role of ABCA1 and SR-BI in Cholesterol Transport and Atherosclerosis

Wednesday, January 26 | 8:00AM - 11:15AM
Cholesterol Efflux and Nuclear Receptors
Room: Red Cloud/Shavano

Speaker 6 of 6
Edward A. Fisher, New York University School of Medicine, USA
Short Talk: Molecular Regulation of Foam Cell Gene Expression After Reversal of Dyslipidemia in a Mouse Atherosclerosis Regression Model

Wednesday, January 26 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Wednesday, January 26 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Shavano Peak Foyer


Wednesday, January 26 | 5:00PM - 7:00PM
Arterial Wall-Based Therapy of Atherosclerosis
Room: Red Cloud/Shavano

Speaker 1 of 3
* Peter Libby, Brigham and Women's Hospital, USA
Diabetes, Metabolic Syndrome and Vessel Wall Therapies

Wednesday, January 26 | 5:00PM - 7:00PM
Arterial Wall-Based Therapy of Atherosclerosis
Room: Red Cloud/Shavano

Speaker 2 of 3
Stefano Martinotti, Clinical Pathology University of Chieti, Italy
Short Talk: A Variant in the COX-2 Promoter Decreases Protein Expression and Influences Plaque Stability

Wednesday, January 26 | 5:00PM - 7:00PM
Arterial Wall-Based Therapy of Atherosclerosis
Room: Red Cloud/Shavano

Speaker 3 of 3
Stefanie Dimmeler, University of Frankfurt, Germany
Progenitor Cells for Vascular Repair

Wednesday, January 26 | 7:00PM - 8:00PM
Social Hour
Room: Crestone Peak


Wednesday, January 26 | 8:00PM - 11:00PM
Entertainment
Room: Crestone Peak


Wednesday, January 26 | 8:00PM - 11:00PM
Cash Bar
Room: Crestone Peak


Thursday, January 27 | 10:26AM - 10:26AM
Departure


*Session Chair.