Frontiers of NMR in Molecular Biology IX

Organizer(s): Brian D. Sykes, Juli Feigon and James H. Prestegard

Supported by The Director's Fund

Summary of Meeting:

Nuclear Magnetic Resonance (NMR) has a long history of evolving to meet new challenges of molecular biology; this evolution will be even more rapid in a genomic and post-genomic era. Already the challenge of providing structures of proteins on a genomic scale has produced new NMR approaches for fast structure determination and the prospect of having more targets for the pharmaceutical industry has spawned new NMR based means of screening for molecular interactions. For the future, NMR is expanding into biologically and medically important areas such as integrated systems biology and metabonomics. There are new demands for working with large complex data sets. The realization that biological function often involves the interplay of groups of macromolecules in a dynamic setting demands new methods for monitoring macromolecular interaction in large systems as well as motion in these systems. The advances needed often come from discussions among scientists expert in solids NMR, macromolecular solution NMR, molecular biology and drug discovery. The ultimate challenge for the meeting will be to stimulate discussion among scientists representing these diverse fields. The meeting will be largely organized around new approaches to the challenges defined above and provide a forum for discussion among molecular biologists, NMR spectroscopists, computational biologists, and drug design specialists. The program will be organized around problem areas and integrate talks by scientists having different perspectives on their solution. Scheduled breaks between formal presentation sessions are ideal for simulating discussion among participants. Discussion of more practical aspects will be promoted by the addition of afternoon workshops having a tutorial structure.

Discounted Abstract Deadline: September 29 2004

Discounted Registration Deadline: November 30 2004

We gratefully acknowledge additional support for this conference from:

Bruker BioSpin Corp.

Cambridge Isotope Laboratories

ISOTEC, a member of the Sigma-Aldrich Group

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Novartis Institutes for BioMedical Research

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of General Medical Sciences (NIGMS)
Grant No. 1R13-GM073374-01

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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