Web Desc
Dendritic Cells at the Center of Innate and Adaptive Immunity: Eradication of Pathogens and Cancer and Control of Immunopathology
Organizer(s): Anne O'Garra, Jacques Banchereau and Alan Sher
Date: February 01 - 07, 2005
Location: Fairmont Hotel Vancouver, Vancouver, BC, Canada
Supported by The Director's Fund
For important information on the coronavirus, please click here
Summary of Meeting:
The decision to activate an immune response is made by unique antigen presenting cells, called dendritic cells that are resting until they encounter foreign microorganisms or inflammatory stimuli. Early activated dendritic cells trigger innate immune responses that represent the first line of defense against invading pathogens to limit the infections. At later times activated they prime antigen-specific immune responses to clear infectious pathogens and give rise to immunological memory. Dendritic cells control the responses of several types of lymphocytes, and are key in the transition between innate and adaptive immunity. They determine the class of the T cell response, including the development of Th1 cells to eradicate pathogens, or conversely unresponsiveness or tolerance, and thus are critical for the development of an effective immune response with minimum immunopathology. This multifaceted role of the dendritic cell will be covered in this meeting in the following areas: (1) Activation and maturation of dendritic cells for the design of successful adjuvants: (2) Molecular signaling pathways in dendritic cells in response to pathogen-derived products and inflammatory mediators: (3) Cell biology of dendritic cells in antigen handling, processing and presentation: (4) Innate functions of dendritic cells in dictating adaptive immune responses: (5) Dendritic cells in allergy and autoimmunity: (6) Dendritic cells in infectious diseases: (7) Dendritic cells and cancer immunotherapy.
Discounted Abstract Deadline: September 30 2004
Discounted Registration Deadline: December 1 2004
We gratefully acknowledge additional support for this conference from:
Novartis Institutes for BioMedical Research
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Dynavax Technologies Corporation
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13-AI063797-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Tuesday, February 01 | 3:00PM - 7:30PM
Registration
Room: BC Foyer


Tuesday, February 01 | 6:30PM - 7:30PM
Refreshments
Room: BC Foyer


Tuesday, February 01 | 7:30PM - 8:30PM
Keynote Address
Room: British/Columbia Ballrooms

Speaker 1 of 2
* Anne O'Garra, Francis Crick Institute, UK

Tuesday, February 01 | 7:30PM - 8:30PM
Keynote Address
Room: British/Columbia Ballrooms

Speaker 2 of 2
Ralph M. Steinman, Rockefeller University, USA
Harnessing Dendritic Cells for Immunity and Tolerance

Wednesday, February 02 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Wednesday, February 02 | 8:00AM - 11:15AM
Activation and Maturation of Dendritic Cells: Adjuvant Prope
rties of Dendritic Cells

Room: British/Columbia Ballrooms

Speaker 1 of 6
* Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA
Human Plasmacytoid and Myeloid Dendritic Cells Encompass Dinstint Subsets

Wednesday, February 02 | 8:00AM - 11:15AM
Activation and Maturation of Dendritic Cells: Adjuvant Prope
rties of Dendritic Cells

Room: British/Columbia Ballrooms

Speaker 2 of 6
* Yong-Jun Liu, Sanofi, USA
Plasmacytoid Dendritic Cells as Frontline Antiviral Agents


Wednesday, February 02 | 8:00AM - 11:15AM
Activation and Maturation of Dendritic Cells: Adjuvant Prope
rties of Dendritic Cells

Room: British/Columbia Ballrooms

Speaker 3 of 6
Carl G. Figdor, Radboud University Medical Center, Netherlands
C-Type Lectins as Antigen Uptake Receptors on Dendritic Cells

Wednesday, February 02 | 8:00AM - 11:15AM
Activation and Maturation of Dendritic Cells: Adjuvant Prope
rties of Dendritic Cells

Room: British/Columbia Ballrooms

Speaker 4 of 6
Siamon Gordon, Chang Gung University / University of Oxford, UK
Immune Recognition and Regulation by Macrophages

Wednesday, February 02 | 8:00AM - 11:15AM
Activation and Maturation of Dendritic Cells: Adjuvant Prope
rties of Dendritic Cells

Room: British/Columbia Ballrooms

Speaker 5 of 6
Frederic Geissmann, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Isolation, Clonogenic Potential and in vivo Differentiation of a Common M-CSF-Dependant Bone Marrow Progenitor Specific for Dendritic Cells and Macrophages

Wednesday, February 02 | 8:00AM - 11:15AM
Activation and Maturation of Dendritic Cells: Adjuvant Prope
rties of Dendritic Cells

Room: British/Columbia Ballrooms

Speaker 6 of 6
SangKon Oh, Baylor Research Institute, USA
Short Talk: Role of IL-15/IL-15Ralpha in Dendritic Cell Activation of T Cells

Wednesday, February 02 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Wednesday, February 02 | 11:15AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Wednesday, February 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Wednesday, February 02 | 2:00PM - 4:00PM
Workshop 1: DC Activation and Maturation
Room: British/Columbia Ballrooms

Speaker 1 of 10
* Marika Sarfati, Centre de Recherche du CHUM, Canada
CD47 is a Negative Regulator of Dendritic Cells in vivo

Wednesday, February 02 | 2:00PM - 4:00PM
Workshop 1: DC Activation and Maturation
Room: British/Columbia Ballrooms

Speaker 2 of 10
Jonathan D. Silk, University of Oxford, UK
Integration of Signals Induced with TLR Ligands with Activation of iNKT Cells Leads to DC Maturation and Enhanced T Cell Expansion in vivo

Wednesday, February 02 | 2:00PM - 4:00PM
Workshop 1: DC Activation and Maturation
Room: British/Columbia Ballrooms

Speaker 3 of 10
Dmitry I. Gabrilovich, Wistar Institute, USA
Bone Marrow Stroma Mediated Regulation of Dendritic Cell differentiation Depends on the Nature of Notch Ligands

Wednesday, February 02 | 2:00PM - 4:00PM
Workshop 1: DC Activation and Maturation
Room: British/Columbia Ballrooms

Speaker 4 of 10
Adam M. Boruchov, Memorial Sloan-Kettering Cancer Center, USA
Co-expressed Activating and Inhibitory Fc gamma Rs Have Opposing Functions on Human DCs

Wednesday, February 02 | 2:00PM - 4:00PM
Workshop 1: DC Activation and Maturation
Room: British/Columbia Ballrooms

Speaker 5 of 10
Jinhua Lu, National University of Singapore, Singapore
CD83 is Preformed Inside Monocytes, Macrophages and Dendritic Cells but it is Only Stably Expressed on Activated Dendritic Cells

Wednesday, February 02 | 2:00PM - 4:00PM
Workshop 1: DC Activation and Maturation
Room: British/Columbia Ballrooms

Speaker 6 of 10
Diana Dudziak, Rockefeller University, USA
33D1 Defines a Novel population of CD11Chigh Splenic Dendritic Cells

Wednesday, February 02 | 2:00PM - 4:00PM
Workshop 1: DC Activation and Maturation
Room: British/Columbia Ballrooms

Speaker 7 of 10
Aurélie Groseil, Genethon, France
The Notch Ligand delta-like-1 Induces Hematopoietic Differentiation into the Plasmacytoid Dendritic Cell Lineage

Wednesday, February 02 | 2:00PM - 4:00PM
Workshop 1: DC Activation and Maturation
Room: British/Columbia Ballrooms

Speaker 8 of 10
Aimin Jiang, Yale University, USA
Regulation of Dendritic Cell Maturation by E-cadherin/beta-catenin Signaling

Wednesday, February 02 | 2:00PM - 4:00PM
Workshop 1: DC Activation and Maturation
Room: British/Columbia Ballrooms

Speaker 9 of 10
Kenji Kabashima, Kyoto University, Japan
Lymphotoxin-beta Receptor Signaling Promotes Dendritic Cell Proliferation in Lymphoid Tissues

Wednesday, February 02 | 2:00PM - 4:00PM
Workshop 1: DC Activation and Maturation
Room: British/Columbia Ballrooms

Speaker 10 of 10
Yumiko Kamogawa-Schifter, Ginkgobiomedical Institute, Japan
Ly49Q Defines Two Subsets of pDCs in Mice

Wednesday, February 02 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: BC Foyer


Wednesday, February 02 | 5:00PM - 7:00PM
Signaling in Dendritic Cells I
Room: British/Columbia Ballrooms

Speaker 1 of 4
* Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
TLR-Mediated Control of Dendritic Cell Functions

Wednesday, February 02 | 5:00PM - 7:00PM
Signaling in Dendritic Cells I
Room: British/Columbia Ballrooms

Speaker 2 of 4
* Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Positive And Negative Signaling in Innate and Adaptive Immunity and It’s Role in the Development of Anti Infectious and Autoimmune Responses


Wednesday, February 02 | 5:00PM - 7:00PM
Signaling in Dendritic Cells I
Room: British/Columbia Ballrooms

Speaker 3 of 4
Alan Aderem, Center for Infectious Disease Research, USA
Systems Biology and Immunity:
“A systems approach to dissecting immunity”


Wednesday, February 02 | 5:00PM - 7:00PM
Signaling in Dendritic Cells I
Room: British/Columbia Ballrooms

Speaker 4 of 4
Hiroshi Watarai, Riken Research Center for Allergy and Immunology, Japan
Short Talk: Molecular Characterization of Three Novel Triggering Receptors on Mouse Splenic DCs

Wednesday, February 02 | 7:00PM - 8:00PM
Social Hour
Room: Pacific Ballroom


Wednesday, February 02 | 7:30PM - 10:00PM
Poster Session 1
Room: Pacific Ballroom


Thursday, February 03 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Thursday, February 03 | 8:00AM - 11:15AM
Dendritic Cells in the Adaptive Immune Response
Room: British/Columbia Ballrooms

Speaker 1 of 6
* Anne O'Garra, Francis Crick Institute, UK
Pro-Inflammatory and Anti-Inflammatory Signals from Dendritic Cells Direct the Adaptive Immune Response

Thursday, February 03 | 8:00AM - 11:15AM
Dendritic Cells in the Adaptive Immune Response
Room: British/Columbia Ballrooms

Speaker 2 of 6
* Federica Sallusto, Università della Svizzera Italiana & ETH Zurich, Switzerland
Human Dendritic Cells and their Role in Triggering T Cell Responses


Thursday, February 03 | 8:00AM - 11:15AM
Dendritic Cells in the Adaptive Immune Response
Room: British/Columbia Ballrooms

Speaker 3 of 6
Ronald N. Germain, NIAID, National Institutes of Health, USA
Visualizing Dendritic Cell - Lymphocyte Interactions in vivo

Thursday, February 03 | 8:00AM - 11:15AM
Dendritic Cells in the Adaptive Immune Response
Room: British/Columbia Ballrooms

Speaker 4 of 6
Muriel Moser, Université Libre de Bruxelles, Belgium
Dendritic Cells as Inducers and Controllers of Immunity

Thursday, February 03 | 8:00AM - 11:15AM
Dendritic Cells in the Adaptive Immune Response
Room: British/Columbia Ballrooms

Speaker 5 of 6
Hans-Christian Reinecker, Massachusetts General Hospital, USA
Short Talk: Control of Dendritic Cell Access to the Intestinal Lumen and of Bacterial Clearance

Thursday, February 03 | 8:00AM - 11:15AM
Dendritic Cells in the Adaptive Immune Response
Room: British/Columbia Ballrooms

Speaker 6 of 6
Bali Pulendran, Stanford University School of Medicine, USA
Short Talk: Dendritic Cell Signaling Networks and Innate Immune Receptors that Induce Th1, Th2 and Tolerogenic Responses

Thursday, February 03 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Thursday, February 03 | 11:15AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Thursday, February 03 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Thursday, February 03 | 2:00PM - 4:00PM
Workshop 2: Dendritic Cells in the Adaptive Immune Response
Room: British/Columbia Ballrooms

Speaker 1 of 9
* Martien L. Kapsenberg, University of Amsterdam, Netherlands

Thursday, February 03 | 2:00PM - 4:00PM
Workshop 2: Dendritic Cells in the Adaptive Immune Response
Room: British/Columbia Ballrooms

Speaker 2 of 9
* Tsuneyasu Kaisho, RIKEN Research Center for Allergy and Immunology, Japan
How Dendritic Cells Process Nucleic Acid Signal?

Thursday, February 03 | 2:00PM - 4:00PM
Workshop 2: Dendritic Cells in the Adaptive Immune Response
Room: British/Columbia Ballrooms

Speaker 3 of 9
Alice V. Banz, DNAX, USA
TSLP Induces Maturation of CD11c+ DC to Support Th2 Polarization

Thursday, February 03 | 2:00PM - 4:00PM
Workshop 2: Dendritic Cells in the Adaptive Immune Response
Room: British/Columbia Ballrooms

Speaker 4 of 9

Lentiviral Vectors Encoding Antigens Transduce Dendritic Cells in Vivo and Initiate CD4 and CD8 Immune Responses

Thursday, February 03 | 2:00PM - 4:00PM
Workshop 2: Dendritic Cells in the Adaptive Immune Response
Room: British/Columbia Ballrooms

Speaker 5 of 9
Gilles Dadaglio, Institut Pasteur, France
Murine Plasmacytoid Dendritic Cells Induce Effector/Memory CD8+ T-cell Responses in Vivo After Viral Stimulation

Thursday, February 03 | 2:00PM - 4:00PM
Workshop 2: Dendritic Cells in the Adaptive Immune Response
Room: British/Columbia Ballrooms

Speaker 6 of 9
Alexander Faith, King's College London, UK
Human Respiratory Tract Dendritic Cells are Susceptible to Modulation: Exposure to GM-CSF Promotes a Th2 Response

Thursday, February 03 | 2:00PM - 4:00PM
Workshop 2: Dendritic Cells in the Adaptive Immune Response
Room: British/Columbia Ballrooms

Speaker 7 of 9
Dragana Jankovic, NIAID, National Institutes of Health, USA
Distinct DC Activation States Associated with Parasite-Induced Th1/Th2 Effector Choice

Thursday, February 03 | 2:00PM - 4:00PM
Workshop 2: Dendritic Cells in the Adaptive Immune Response
Room: British/Columbia Ballrooms

Speaker 8 of 9
Eynav Klechevsky, Washington University School of Medicine, USA
Langerhans Cells within CD34-DC Efficiently Prime Melanoma Specific CD8+ T Cells

Thursday, February 03 | 2:00PM - 4:00PM
Workshop 2: Dendritic Cells in the Adaptive Immune Response
Room: British/Columbia Ballrooms

Speaker 9 of 9
John W. Upham, Princess Alexandra Hospital, Australia
The Expression of Allergen Specific T-cell Memory is Critically Dependent on DC Activation/Maturation

Thursday, February 03 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: BC Foyer


Thursday, February 03 | 5:00PM - 7:00PM
Signaling in Dendritic Cells II
Room: British/Columbia Ballrooms

Speaker 1 of 6
* Ralph M. Steinman, Rockefeller University, USA

Thursday, February 03 | 5:00PM - 7:00PM
Signaling in Dendritic Cells II
Room: British/Columbia Ballrooms

Speaker 2 of 6
Kasper Hoebe, The Scripps Research Institute, USA
TIR-Dependent and -Independent Immunoadjuvant Pathways

Thursday, February 03 | 5:00PM - 7:00PM
Signaling in Dendritic Cells II
Room: British/Columbia Ballrooms

Speaker 3 of 6
* Brian L. Kelsall, NIAID, National Institutes of Health, USA
Regulation of Dendritic Cell Function by G-Protein Coupled Receptors

Thursday, February 03 | 5:00PM - 7:00PM
Signaling in Dendritic Cells II
Room: British/Columbia Ballrooms

Speaker 4 of 6
Cynthia A. Leifer, Cornell University, USA
Short Talk: TLR9 ER Localization and Early Endosome Targeting are Controlled by Discrete Cytoplasmic Motifs

Thursday, February 03 | 5:00PM - 7:00PM
Signaling in Dendritic Cells II
Room: British/Columbia Ballrooms

Speaker 5 of 6
Atsushi Kumanogoh, Osaka University, Japan
Short Talk: A Class IV Semaphorin Sema4A Plays Non-Redundant Roles in T-Cell Priming and Th1/Th2 Regulation

Thursday, February 03 | 5:00PM - 7:00PM
Signaling in Dendritic Cells II
Room: British/Columbia Ballrooms

Speaker 6 of 6
Russell D. Salter, University of Pittsburgh, USA
Short Talk: Title to be Determined

Thursday, February 03 | 7:00PM - 8:00PM
Social Hour
Room: Pacific Ballroom


Thursday, February 03 | 7:30PM - 10:00PM
Poster Session 2
Room: Pacific Ballroom


Friday, February 04 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Friday, February 04 | 8:00AM - 11:00AM
Cell Biology of Dendritic Cells
Room: British/Columbia Ballrooms

Speaker 1 of 6
* Ira Mellman, Genentech, Inc., USA
Inside Dendritic Cells, Brightly


Friday, February 04 | 8:00AM - 11:00AM
Cell Biology of Dendritic Cells
Room: British/Columbia Ballrooms

Speaker 2 of 6
* Sebastian Amigorena, Institut Curie, France
Dendritic Cell-T Cell Interactions for the Induction of Priming and Tolerance

Friday, February 04 | 8:00AM - 11:00AM
Cell Biology of Dendritic Cells
Room: British/Columbia Ballrooms

Speaker 3 of 6
Jatin M. Vyas, Massachusetts General Hospital, USA
Short Talk: CD63 and Class II MHC Colocalization within the DC Endocytic Pathway

Friday, February 04 | 8:00AM - 11:00AM
Cell Biology of Dendritic Cells
Room: British/Columbia Ballrooms

Speaker 4 of 6
Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Dendritic Cell Networks in Intact Lymph Nodes

Friday, February 04 | 8:00AM - 11:00AM
Cell Biology of Dendritic Cells
Room: British/Columbia Ballrooms

Speaker 5 of 6
Barbara Fazekas de St. Groth, Centenary Institute, Australia
Short Talk: Transfer of Intact Peptide-MHC II Complexes between Dendritic Cells in vivo

Friday, February 04 | 8:00AM - 11:00AM
Cell Biology of Dendritic Cells
Room: British/Columbia Ballrooms

Speaker 6 of 6
Amy K. Bergtold, Columbia University, USA
Short Talk: Antigens Acquired Through FcRII on Dendritic Cells Are Retained and Recycled to the Cell Surface for B Cell Priming

Friday, February 04 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Friday, February 04 | 11:15AM - 12:00PM
Poster Setup
Room: Pacific Ballroom


Friday, February 04 | 11:15AM - 12:00PM
Lunch
Room: Pacific Ballroom


Friday, February 04 | 11:30AM - 2:00PM
Poster Session 3
Room: Pacific Ballroom


Friday, February 04 | 2:00PM - 4:00PM
Workshop 3: Antigen Processing By Dendritic Cells
Room: British Ballroom

Speaker 1 of 7
* Philippe D. Pierre, Centre d'Immunologie Marseille-Luminy, CIML, France

Friday, February 04 | 2:00PM - 4:00PM
Workshop 3: Antigen Processing By Dendritic Cells
Room: British Ballroom

Speaker 2 of 7
Arne Bakker, Netherlands Cancer Institute, Netherlands
The Efficiency Of Cross-Presentation By Dendritic Cells

Friday, February 04 | 2:00PM - 4:00PM
Workshop 3: Antigen Processing By Dendritic Cells
Room: British Ballroom

Speaker 3 of 7
Laura A. Johnson, Abramson Family Cancer Research Institute, University of Pennsylvania, USA
ABCB9 is an ABC-transporter Gene that Plays a Crucial Role in Cross-Priming by Dendritic Cells

Friday, February 04 | 2:00PM - 4:00PM
Workshop 3: Antigen Processing By Dendritic Cells
Room: British Ballroom

Speaker 4 of 7
Liying Chen, Karolinska Institute, Sweden
Alternative Processing for MHC Class I Presentation by Immature and CpG-activated Dendritic Cells.

Friday, February 04 | 2:00PM - 4:00PM
Workshop 3: Antigen Processing By Dendritic Cells
Room: British Ballroom

Speaker 5 of 7
Vivien Watson, University of Southampton, UK
Calreticulin Does Not Enhance Presentation of A Model Antigen by Dendritic Cells

Friday, February 04 | 2:00PM - 4:00PM
Workshop 3: Antigen Processing By Dendritic Cells
Room: British Ballroom

Speaker 6 of 7
Andrew W. Lee, Cardiology Associates Medical Group, USA
Human Cytomegalovirus Causes Redistribution of MHC Class II Away from the Cell Surface in Mature Langerhans Cells.

Friday, February 04 | 2:00PM - 4:00PM
Workshop 3: Antigen Processing By Dendritic Cells
Room: British Ballroom

Speaker 7 of 7
Randy S. Longman, Weill Cornell Medical College, USA
Yellow Fever 17D Infects Human Dendritic Cells Allowing for Processing/Presentation of Endogenous and Model T cell Epitopes

Friday, February 04 | 2:00PM - 4:00PM
Workshop 4: Dendritic Cells in Tolerance
Room: Columbia Ballroom

Speaker 1 of 9
* Ranjeny Thomas, University of Queensland, Australia
Antigen Specific Effector Cells Inhibit Tolerance Induction in Autoimmune-Prone NOD Mice

Friday, February 04 | 2:00PM - 4:00PM
Workshop 4: Dendritic Cells in Tolerance
Room: Columbia Ballroom

Speaker 2 of 9
Anuradha Ray, University of Pittsburgh School of Medicine, USA
Dynamics of Dendritic Cell Phenotype and Interactions with CD4+ T Cells in Airway Inflammation Versus Tolerance

Friday, February 04 | 2:00PM - 4:00PM
Workshop 4: Dendritic Cells in Tolerance
Room: Columbia Ballroom

Speaker 3 of 9
Hozefa S. Bandukwala, Rheos Medicines, USA
Signaling via Fc gamma Receptors on Dendritic Cells Modulates Their Cytokine Production and Ability to Direct T cell Differentiation in Vitro and in Vivo.

Friday, February 04 | 2:00PM - 4:00PM
Workshop 4: Dendritic Cells in Tolerance
Room: Columbia Ballroom

Speaker 4 of 9
Franck J. Barrat, Hospital for Special Surgery, USA
Oligonucleotide-based Inhibitors of TLR -7, -8 and -9 and Their Potential for the Treatment of Lupus

Friday, February 04 | 2:00PM - 4:00PM
Workshop 4: Dendritic Cells in Tolerance
Room: Columbia Ballroom

Speaker 5 of 9
Lorenza Frisoni, University of Pennsylvania, USA
Autoantigen-dependent Phagocytosis by Dendritic Cells: A Pathogenic Role for Opsonized Apoptotic Blebs in Systemic Lupus Erythematosus

Friday, February 04 | 2:00PM - 4:00PM
Workshop 4: Dendritic Cells in Tolerance
Room: Columbia Ballroom

Speaker 6 of 9
Stéphanie Hugues, Université de Genève, Switzerland
Distinct T Cell Dynamics In Lymph Nodes During the Induction of Tolerance and Immunity

Friday, February 04 | 2:00PM - 4:00PM
Workshop 4: Dendritic Cells in Tolerance
Room: Columbia Ballroom

Speaker 7 of 9
Grant C. Hughes, University of Washington, USA
Estrogen Regulates Plasmacytoid Dendritic Cell Functions

Friday, February 04 | 2:00PM - 4:00PM
Workshop 4: Dendritic Cells in Tolerance
Room: Columbia Ballroom

Speaker 8 of 9
Cherry I. Kingsley, Brigham and Women's Hospital, USA
Mucosal Tolerance Induction: The Role of the ICOS-ICOSL Pathway

Friday, February 04 | 2:00PM - 4:00PM
Workshop 4: Dendritic Cells in Tolerance
Room: Columbia Ballroom

Speaker 9 of 9
Kristin V. Tarbell, Amgen, USA
Islet-specific CD4+CD25+ Regulatory T Cells Can be Expanded From a Polyclonal Repertoire by Using Dendritic Cells

Friday, February 04 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: BC Foyer


Friday, February 04 | 5:00PM - 7:15PM
Dendritic Cells In Autoimmunity and Allergy
Room: British/Columbia Ballrooms

Speaker 1 of 5
Virginia Pascual, Cornell University, USA
Dendritic Cell Guilt in Systemic Lupus and Systemic Arthritis

Friday, February 04 | 5:00PM - 7:15PM
Dendritic Cells In Autoimmunity and Allergy
Room: British/Columbia Ballrooms

Speaker 2 of 5
* Robert L. Coffman, Dynavax Technologies, USA
Regulation of Dendritic Cells by Stimulatory and Inhibitory Oligonucleotides

Friday, February 04 | 5:00PM - 7:15PM
Dendritic Cells In Autoimmunity and Allergy
Room: British/Columbia Ballrooms

Speaker 3 of 5
* Fiona M. Powrie, University of Oxford, UK
Role of Dendritic Cells in the Regulation of Intestinal Inflammation

Friday, February 04 | 5:00PM - 7:15PM
Dendritic Cells In Autoimmunity and Allergy
Room: British/Columbia Ballrooms

Speaker 4 of 5
Bart N. Lambrecht, VIB, Ghent University, Belgium
Short Talk: Dendritic Cell Subsets and Control of Allergic Airway Inflammation

Friday, February 04 | 5:00PM - 7:15PM
Dendritic Cells In Autoimmunity and Allergy
Room: British/Columbia Ballrooms

Speaker 5 of 5
Michel Gilliet, University Hospital of Lausanne, Switzerland
Short Talk: Plasmacytoid Dendritic Cells in Psoriasis


Saturday, February 05 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Saturday, February 05 | 8:00AM - 11:15AM
Dendritic Cells in Infectious Diseases I
Room: British/Columbia Ballrooms

Speaker 1 of 7
Marc K. Jenkins, University of Minnesota Medical School, USA
In situ Analysis of Antigen Presentation to CD4 T Cells

Saturday, February 05 | 8:00AM - 11:15AM
Dendritic Cells in Infectious Diseases I
Room: British/Columbia Ballrooms

Speaker 2 of 7
* Caetano Reis e Sousa, Francis Crick Institute, UK
Innate Pathways for Activation of Dendritic Cells

Saturday, February 05 | 8:00AM - 11:15AM
Dendritic Cells in Infectious Diseases I
Room: British/Columbia Ballrooms

Speaker 3 of 7
* Paola Ricciardi-Castagnoli, Toscana Life Science Foundation, Italy
Dendritic Cells in the Innate Response to Bacteria

Saturday, February 05 | 8:00AM - 11:15AM
Dendritic Cells in Infectious Diseases I
Room: British/Columbia Ballrooms

Speaker 4 of 7
Christine A. Biron, Brown University, USA
Dendritic Cells in the Innate Response to Viral Infections

Saturday, February 05 | 8:00AM - 11:15AM
Dendritic Cells in Infectious Diseases I
Room: British/Columbia Ballrooms

Speaker 5 of 7
Akiko Iwasaki, HHMI/Yale University School of Medicine, USA
Short Talk: Role of Tlrs in the Response of Dendritic Cells to Viruses

Saturday, February 05 | 8:00AM - 11:15AM
Dendritic Cells in Infectious Diseases I
Room: British/Columbia Ballrooms

Speaker 6 of 7
Robert A. Seder, NIAID, National Institutes of Health, USA
Short Talk: Comparative Analysis of TLR 7/8, TLR 8 Agonists and CpG ODN as Vaccine Adjuvants with HIV Gag Protein in Non-Human Primates

Saturday, February 05 | 8:00AM - 11:15AM
Dendritic Cells in Infectious Diseases I
Room: British/Columbia Ballrooms

Speaker 7 of 7
Sylvie Bertholet, GlaxoSmithKline Vaccines, USA
Short Talk: The Presentation of Antigens Released into the Leishmania Phagosome is TAP-independent and thus Avoid the Efficient Presentation Machinery Associated with ER-Mediated Phagocytosis by Dendritic Cells

Saturday, February 05 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Saturday, February 05 | 11:15AM - 12:00PM
Poster Setup
Room: Pacific Ballroom


Saturday, February 05 | 11:15AM - 12:00PM
Lunch
Room: Pacific Ballroom


Saturday, February 05 | 11:30AM - 2:00PM
Poster Session 4
Room: Pacific Ballroom


Saturday, February 05 | 2:00PM - 4:00PM
Workshop 5: Dendritic Cells In Infectious Diseases
Room: British Ballroom

Speaker 1 of 8
* Kingston H.G. Mills, Trinity College Dublin, Ireland
Pathogen-Derived Molecules Direct Regulatory T Cell Induction by Modulating Dendritic Cell Activation

Saturday, February 05 | 2:00PM - 4:00PM
Workshop 5: Dendritic Cells In Infectious Diseases
Room: British Ballroom

Speaker 2 of 8
Winfried Barchet, University Hospital of Bonn, Germany
Dendritic Cells Respond to Influenza Virus through TLR7- and PKR-Independent Pathways

Saturday, February 05 | 2:00PM - 4:00PM
Workshop 5: Dendritic Cells In Infectious Diseases
Room: British Ballroom

Speaker 3 of 8
Silvia B. Boscardin, University of São Paulo, Brazil
Vaccination Using A Plasmodium Protein Delivered Directly to Dendritic Cells

Saturday, February 05 | 2:00PM - 4:00PM
Workshop 5: Dendritic Cells In Infectious Diseases
Room: British Ballroom

Speaker 4 of 8
Sandra S. Diebold, UK
Toll-Like Receptor 3 Mediates Dendritic Cell Activation by Virus-Infected Cells and Promotes Cross-Priming in vivo

Saturday, February 05 | 2:00PM - 4:00PM
Workshop 5: Dendritic Cells In Infectious Diseases
Room: British Ballroom

Speaker 5 of 8
Malin Sundquist, Gothenburg university, Sweden
Mechanism of in vivo Dendritic Cell Maturation in Response to Oral Salmonella Infection

Saturday, February 05 | 2:00PM - 4:00PM
Workshop 5: Dendritic Cells In Infectious Diseases
Room: British Ballroom

Speaker 6 of 8
Jean Langhorne, Francis Crick Institute, UK
The Role of Subsets of Dendritic Cells in Malaria Infection

Saturday, February 05 | 2:00PM - 4:00PM
Workshop 5: Dendritic Cells In Infectious Diseases
Room: British Ballroom

Speaker 7 of 8
Kazuhiko Takahara, Kyoto University, Japan
Microbe Recognition and Involvement in TLR4-Mediated Response of SIGNR1, a Mouse DC-SIGN Homologue

Saturday, February 05 | 2:00PM - 4:00PM
Workshop 5: Dendritic Cells In Infectious Diseases
Room: British Ballroom

Speaker 8 of 8
Jianfang Zhou, University of Hong Kong, China
Upregulation of Death Receptor Ligands in Human Antigen Presenting Cells by Avian Flu Viruses: a Mechanism for the Unusual Severity of Human Diseases?

Saturday, February 05 | 2:00PM - 4:00PM
Workshop 6: Dendritic Cells and Cancer Immunotherapy
Room: Columbia Ballroom

Speaker 1 of 8
* Laurence Zitvogel, Institut Gustave Roussy, France

Saturday, February 05 | 2:00PM - 4:00PM
Workshop 6: Dendritic Cells and Cancer Immunotherapy
Room: Columbia Ballroom

Speaker 2 of 8
Caroline Aspord, EFS / Inserm 823, France
Human Breast Cancer and Melanoma Differentially Modulate Dendritic Cells in OncoHumouse

Saturday, February 05 | 2:00PM - 4:00PM
Workshop 6: Dendritic Cells and Cancer Immunotherapy
Room: Columbia Ballroom

Speaker 3 of 8
Dirk G. Brockstedt, FLX Bio, Inc., USA
Killed but Metabolically Active Recombinant Listeria monocytogenes as an Antigen Delivery and Activation Platform for Human Dendritic Cell-Based Cancer Immunotherapy

Saturday, February 05 | 2:00PM - 4:00PM
Workshop 6: Dendritic Cells and Cancer Immunotherapy
Room: Columbia Ballroom

Speaker 4 of 8
Kevin C. Evel-Kabler, University of California, San Francisco, USA
Critical Regulation of Antigen Presentation by SOCS1 in Dendritic Cells and Enhancement of Antitumor Immunity by SOCS1 Silencing

Saturday, February 05 | 2:00PM - 4:00PM
Workshop 6: Dendritic Cells and Cancer Immunotherapy
Room: Columbia Ballroom

Speaker 5 of 8
Yutaro Nakamura, University of Pittsburgh, Hillman Cancer Center, USA
Heterologous 'CD8 Help' Promotes the Induction of Therapeutic Tumor Immunity

Saturday, February 05 | 2:00PM - 4:00PM
Workshop 6: Dendritic Cells and Cancer Immunotherapy
Room: Columbia Ballroom

Speaker 6 of 8
Kang Liu, Columbia University Medical Center, USA
Tumor Cell Uptake by Dendritic Cells Maturing to Innate NKT Lymphocytes Confers Superior Adaptive Immunity

Saturday, February 05 | 2:00PM - 4:00PM
Workshop 6: Dendritic Cells and Cancer Immunotherapy
Room: Columbia Ballroom

Speaker 7 of 8
Weiping Zou, University of Michigan, USA
Tumor Environmental Regulatory T Cells Disable Dendritic Cell Immunogenecity by Triggering B7-H4

Saturday, February 05 | 2:00PM - 4:00PM
Workshop 6: Dendritic Cells and Cancer Immunotherapy
Room: Columbia Ballroom

Speaker 8 of 8
Nizar J. Bahlis, University of Calgary, Canada
Dendritic Cells Support the Survival of Malignant Plasma Cells in Multiple Myeloma

Saturday, February 05 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: BC Foyer


Saturday, February 05 | 5:00PM - 7:15PM
Dendritic Cells in Infectious Diseases II
Room: British/Columbia Ballrooms

Speaker 1 of 5
* Alan Sher, NIAID, National Institutes of Health, USA
Initiating and Th1 Polarizing Functions of Dendritic Cells in the Immune Response to Toxoplasma gondii

Saturday, February 05 | 5:00PM - 7:15PM
Dendritic Cells in Infectious Diseases II
Room: British/Columbia Ballrooms

Speaker 2 of 5
Nicolas Glaichenhaus, Centre National de la Recherche Scientifique, France
NK cells are slow motile cells localized in the lymph node outerparacortex where they make contacts with dendritic cells

Saturday, February 05 | 5:00PM - 7:15PM
Dendritic Cells in Infectious Diseases II
Room: British/Columbia Ballrooms

Speaker 3 of 5
* Edward J. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Short Talk: Dendritic Cell Regulation of Helminth Induced Th2 Responses

Saturday, February 05 | 5:00PM - 7:15PM
Dendritic Cells in Infectious Diseases II
Room: British/Columbia Ballrooms

Speaker 4 of 5
Elina I. Zuniga, University of California, San Diego, USA
Influence of Virus Infection on Dendritic Cell Generation

Saturday, February 05 | 5:00PM - 7:15PM
Dendritic Cells in Infectious Diseases II
Room: British/Columbia Ballrooms

Speaker 5 of 5
John E. Connolly, Tessa Therapeutics Ltd., Singapore
Short Talk: Respiratory Syncytial Virus Blocks Antigen Presentation by Dendritic Cells

Sunday, February 06 | 7:00AM - 8:30AM
Breakfast
Room: Pacific Ballroom


Sunday, February 06 | 8:00AM - 11:00AM
Dendritic Cells and Cancer Immunotherapy
Room: British/Columbia Ballrooms

Speaker 1 of 6
Gerold Schuler, University Hospital of Erlangen, Germany
Vaccination with Mature Monocyte-Derived Dendritic Cells against Metastatic Melanoma

Sunday, February 06 | 8:00AM - 11:00AM
Dendritic Cells and Cancer Immunotherapy
Room: British/Columbia Ballrooms

Speaker 2 of 6
Hideki Ueno, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Immunomonitoring in Therapeutic Intervention in Clinical Disease

Sunday, February 06 | 8:00AM - 11:00AM
Dendritic Cells and Cancer Immunotherapy
Room: British/Columbia Ballrooms

Speaker 3 of 6
* Olivera J. Finn, University of Pittsburgh School of Medicine, USA
Interaction of Tumor Antigens and Dendritic Cells, a Trap and a Way Out

Sunday, February 06 | 8:00AM - 11:00AM
Dendritic Cells and Cancer Immunotherapy
Room: British/Columbia Ballrooms

Speaker 4 of 6
Cornelis J. M. Melief, Leiden University Medical Center & ISA Pharmaceuticals BV, Netherlands
Activation of Dendritic Cells that Cross-Present Tumor Derived Antigen Licences CD8+ Cytotoxic T-Lymphocytes to Cause Tumor Eradication1

Sunday, February 06 | 8:00AM - 11:00AM
Dendritic Cells and Cancer Immunotherapy
Room: British/Columbia Ballrooms

Speaker 5 of 6
Arthur M. Krieg, Checkmate Pharmaceuticals, USA
Short Talk: Improved Chemotherapy Response Rate In Metastatic Non-Small Cell Lung Cancer By In Vivo Plasmacytoid Dendritic Cell Activation With CPG 7909, A TLR9 Agonist

Sunday, February 06 | 8:00AM - 11:00AM
Dendritic Cells and Cancer Immunotherapy
Room: British/Columbia Ballrooms

Speaker 6 of 6
† W. Martin Kast, University of Southern California, USA
Short Talk: HPV can Escape Immune Recognition through Langerhans Cell PI3-Kinase Activation

Sunday, February 06 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Sunday, February 06 | 2:00PM - 4:00PM
Workshop 7: Dendritic Cells In Infectious Diseases
Room: British/Columbia Ballrooms

Speaker 1 of 8
* Julio Aliberti, NIAID, National Institutes of Health, USA
SOCS-2 is Essential for Lipoxin-Mediated Inhibition of Dendritic Cell IL-12 Production

Sunday, February 06 | 2:00PM - 4:00PM
Workshop 7: Dendritic Cells In Infectious Diseases
Room: British/Columbia Ballrooms

Speaker 2 of 8
* Anne Hosmalin, Institut Cochin, Inserm U1016, Université Paris Descartes, France
HIV Antigen Presentation by Dendritic Cells

Sunday, February 06 | 2:00PM - 4:00PM
Workshop 7: Dendritic Cells In Infectious Diseases
Room: British/Columbia Ballrooms

Speaker 3 of 8
Erica Andersen-Nissen, Hutchinson Centre Research Institute of South Africa, South Africa
Toll-Like Receptor 5 Evasion by Flagellated Bacteria

Sunday, February 06 | 2:00PM - 4:00PM
Workshop 7: Dendritic Cells In Infectious Diseases
Room: British/Columbia Ballrooms

Speaker 4 of 8
Bumsuk Hahm, University of Missouri-Columbia, USA
Virus-Induced Suppression of Dendritic Cell Development through Type I Interferon-Mediated STAT2-Dependent but STAT1-Independent Signaling

Sunday, February 06 | 2:00PM - 4:00PM
Workshop 7: Dendritic Cells In Infectious Diseases
Room: British/Columbia Ballrooms

Speaker 5 of 8
Hiroki Kato, Institute for Virus Research, Japan
Cell Type Specific Involvement of RIG-I in Antiviral Response

Sunday, February 06 | 2:00PM - 4:00PM
Workshop 7: Dendritic Cells In Infectious Diseases
Room: British/Columbia Ballrooms

Speaker 6 of 8
Anna Smed Sörensen, Karolinska Institutet, Sweden
Differential Susceptibility to HIV-1 Infection of Myeloid and Plasmacytoid Dendritic Cells

Sunday, February 06 | 2:00PM - 4:00PM
Workshop 7: Dendritic Cells In Infectious Diseases
Room: British/Columbia Ballrooms

Speaker 7 of 8
Sachiko Akashi-Takamura, Aichi Medical University, Japan
Anti-Toll Like Receptor 4 Antibody Protects Mice from Acute Lethal Hepatitis Induced by Tumor Necrosis Factor-alpha

Sunday, February 06 | 2:00PM - 4:00PM
Workshop 7: Dendritic Cells In Infectious Diseases
Room: British/Columbia Ballrooms

Speaker 8 of 8
Santhi Gorantla, University of Nebraska Medical Center, USA
Short Talk: Human Dendritic Cells Transduced with Herpes Simplex Virus (HSV) Amplicons Encoding HIV-1gp120 Elicit Adaptive Immune Responses from Human Cells Engrafted into NOD/SCID Mice and Confer Partial Protection against HIV-1 Challenge

Sunday, February 06 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: BC Foyer


Sunday, February 06 | 5:00PM - 7:00PM
Dendritic Cells in the Innate Immune Response
Room: British/Columbia Ballrooms

Speaker 1 of 4
Tadatsugu Taniguchi, University of Tokyo, Japan
Interferons and IRFs in TLR Activation of Dendritic Cells

Sunday, February 06 | 5:00PM - 7:00PM
Dendritic Cells in the Innate Immune Response
Room: British/Columbia Ballrooms

Speaker 2 of 4
* Giorgio Trinchieri, NCI, National Institutes of Health, USA
Role of Plasmacytoid Dendritic Cells in vivo


Sunday, February 06 | 5:00PM - 7:00PM
Dendritic Cells in the Innate Immune Response
Room: British/Columbia Ballrooms

Speaker 3 of 4
Christopher W. Schmidt, Queensland Institute of Medical Research, Australia
Short Talk: Correlation of Clinical and Immunological Responses Following Dendritic Cell Immunotherapy

Sunday, February 06 | 5:00PM - 7:00PM
Dendritic Cells in the Innate Immune Response
Room: British/Columbia Ballrooms

Speaker 4 of 4


Sunday, February 06 | 7:00PM - 8:00PM
Social Hour
Room: Pacific Ballroom


Sunday, February 06 | 8:00PM - 11:00PM
Entertainment
Room: Pacific Ballroom


Sunday, February 06 | 8:00PM - 11:00PM
Cash Bar
Room: Pacific Ballroom


Monday, February 07 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.