Web Desc
Cytokines, Disease and Therapeutic Intervention
Organizer(s): John J. O'Shea, Robert Kastelein and Mary Collins
Date: February 12 - 17, 2005
Location: Eldorado Hotel & Spa, Santa Fe, NM, USA
Sponsored by Lilly Research Laboratories and The Director's Fund
For important information on the coronavirus, please click here
Summary of Meeting:
With the completion of the human genome project, we will shortly know all of the cytokines encoded within our genome. Indeed within the last few years, there have been reports of at least ten new cytokines. While this will provide us with our 'deck of cards', it is also clear that surprises continue to emerge regarding the function of cytokines we thought we knew well. Therefore, a major remaining problem is the understanding of the in vivo role of all these cytokines. Our comprehension of how cytokines work in concert in the protection against pathogens and in the pathogenesis of immune-mediated disease remains limited. Furthermore, the role of cytokines in immune homeostasis, lymphocyte memory and peripheral tolerance are actively being investigated. Equally exciting is the emergence of new cytokine and anti-cytokine therapies that have been remarkably effective. Our goals in this meeting are to review information on the newest cytokines, to provide new insights on their function in host defense and disease pathogenesis, to discuss new findings related to cytokine signaling and structure and to present the latest information on how manipulation of cytokines can be used therapeutically.
Discounted Abstract Deadline: October 12 2004
Discounted Registration Deadline: December 13 2004
Late Abstracts


We gratefully acknowledge additional support for this conference from:
Lilly Research LaboratoriesNovartis Institutes for BioMedical Research
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Abbott Bioresearch Center

Biogen Idec

DNAX Research Institute

Educational donation provided by Amgen

Genentech, Inc.

Wyeth Research Labs
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13-AI063645-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Saturday, February 12 | 3:00PM - 7:30PM
Registration
Room: Zia Concourse


Saturday, February 12 | 6:30PM - 7:30PM
Refreshments
Room: Sunset Room


Saturday, February 12 | 7:30PM - 8:30PM
Keynote Address
Room: Anasazi Ballroom

Speaker 1 of 1
Tim R. Mosmann, University of Rochester Medical Center, USA
T Helper Cell Differentiation Then and Now

Sunday, February 13 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Sunday, February 13 | 8:00AM - 11:15AM
Type I Cytokines and Immunoregulation
Room: Anasazi Ballroom

Speaker 1 of 5
Rose Zamoyska, University of Edinburgh, UK
IL-7 and Receptor Signals that Regulate Lymphocyte Homeostasis

Sunday, February 13 | 8:00AM - 11:15AM
Type I Cytokines and Immunoregulation
Room: Anasazi Ballroom

Speaker 2 of 5
Warren J. Leonard, National Institutes of Health, USA
IL-21 and Regulation of B Cell Function

Sunday, February 13 | 8:00AM - 11:15AM
Type I Cytokines and Immunoregulation
Room: Anasazi Ballroom

Speaker 3 of 5
* Christopher A. Hunter, University of Pennsylvania, USA
The Role of IL-27 in the Regulation of Th1 and Th2 Responses during Parasitic Infection

Sunday, February 13 | 8:00AM - 11:15AM
Type I Cytokines and Immunoregulation
Room: Anasazi Ballroom

Speaker 4 of 5
Daniel J. Cua, Janssen Pharmaceutical Companies of Johnson & Johnson, USA
The Role of IL-23 in Chronic Inflammation

Sunday, February 13 | 8:00AM - 11:15AM
Type I Cytokines and Immunoregulation
Room: Anasazi Ballroom

Speaker 5 of 5
Nico P. Ghilardi, DiCE Molecules, USA
The Role of IL-27 in Autoimmune Disease

Sunday, February 13 | 9:20AM - 9:40AM
Coffee Break
Room: South Concourse


Sunday, February 13 | 11:15AM - 1:00PM
Poster Setup
Room: Sunset Room


Sunday, February 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room


Sunday, February 13 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: South Concourse


Sunday, February 13 | 5:00PM - 7:00PM
Cytokine Signaling
Room: Anasazi Ballroom

Speaker 1 of 4
John J. O'Shea, NIAMS, National Institutes of Health, USA
Signaling by Type I/II Cytokines

Sunday, February 13 | 5:00PM - 7:00PM
Cytokine Signaling
Room: Anasazi Ballroom

Speaker 2 of 4
* Luke A. J. O'Neill, Trinity Biomedical Sciences Institute, Ireland
Signaling by IL-1 Receptor / Toll-Like Receptor Superfamily

Sunday, February 13 | 5:00PM - 7:00PM
Cytokine Signaling
Room: Anasazi Ballroom

Speaker 3 of 4
Daniel Kastner, National Institutes of Health, USA
The Systemic Autoinflammatory Diseases: Inherited Disorders of Cytokine Signaling

Sunday, February 13 | 5:00PM - 7:00PM
Cytokine Signaling
Room: Anasazi Ballroom

Speaker 4 of 4
Steven F. Ziegler, Benaroya Research Institute, USA
Short Talk: In Vivo Responses to Thymic Stromal Lymphopoietin (TSLP).

Sunday, February 13 | 7:00PM - 8:00PM
Social Hour
Room: Eldorado Court/Sunset Room


Sunday, February 13 | 7:30PM - 10:00PM
Poster Session 1
Room: Sunset Room


Monday, February 14 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Monday, February 14 | 8:00AM - 11:15AM
Cytokines in Inflammation and Development
Room: Anasazi Ballroom

Speaker 1 of 6
Susan L. Kalled, Shire Human Genetic Therapies, USA
BAFF Function in the Immune System: Prospects for the Utility of BAFF Blockade in Treating Autoimmune Disorders

Monday, February 14 | 8:00AM - 11:15AM
Cytokines in Inflammation and Development
Room: Anasazi Ballroom

Speaker 2 of 6
John E. Sims, Amgen Inc., USA
IL-1 and IL-1R Family Members in Inflammatory Skin Disease

Monday, February 14 | 8:00AM - 11:15AM
Cytokines in Inflammation and Development
Room: Anasazi Ballroom

Speaker 3 of 6
* Robert A. Kastelein, Merck Research Labs, USA
The Role of IL-23 in Chronic Inflammation Part II

Monday, February 14 | 8:00AM - 11:15AM
Cytokines in Inflammation and Development
Room: Anasazi Ballroom

Speaker 4 of 6
Lothar Hennighausen, National Institutes of Health, USA
The Physiology and Cell-Specificity of Stat5 Signaling

Monday, February 14 | 8:00AM - 11:15AM
Cytokines in Inflammation and Development
Room: Anasazi Ballroom

Speaker 5 of 6
Chaim Putterman, Albert Einstein College of Medicine, USA
Short Talk: TWEAK, a Novel TNF Ligand Superfamily Member, Induces Pro-Inflammatory Chemokines in Kidney Mesangial Cells

Monday, February 14 | 8:00AM - 11:15AM
Cytokines in Inflammation and Development
Room: Anasazi Ballroom

Speaker 6 of 6
Linda C. Burkly, Biogen, Inc., USA
Short Talk: Anti-TWEAK mAbs Inhibit Mouse and Rat Collagen-Induced Arthritis

Monday, February 14 | 9:20AM - 9:40AM
Coffee Break
Room: South Concourse


Monday, February 14 | 11:00AM - 1:00PM
Poster Setup
Room: Sunset Room


Monday, February 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room


Monday, February 14 | 3:00PM - 4:30PM
Workshop 1: IL-17
Room: Anasazi Ballroom

Speaker 1 of 4
Florencia M. Mc Allister, USA
IL-17 Pro-Inflammatory Responses in Human Bronchial Epithelial Cells: Implicationas for Cystic Fibrosis

Monday, February 14 | 3:00PM - 4:30PM
Workshop 1: IL-17
Room: Anasazi Ballroom

Speaker 2 of 4
Steven D. Levin, Alpine Immune Sciences, USA
Human and Mouse IL-17A and IL-17F Differentially Bind IL-17RA and IL-17RC

Monday, February 14 | 3:00PM - 4:30PM
Workshop 1: IL-17
Room: Anasazi Ballroom

Speaker 3 of 4
* Sarah L. Gaffen, University of Pittsburgh, USA
Gene Targets of Interleukin-17 Receptor Signaling: Relationship to Inflammatory Bone Disease

Monday, February 14 | 3:00PM - 4:30PM
Workshop 1: IL-17
Room: Anasazi Ballroom

Speaker 4 of 4
Alex M. Owyang, Rigel Pharmaceuticals Inc, USA
IL-25 is Required for the Regulation of Autoimmunity and Immunity to Parasites

Monday, February 14 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: South Concourse


Monday, February 14 | 5:00PM - 7:00PM
Type II and Other Cytokines
Room: Anasazi Ballroom

Speaker 1 of 4
* Rene de Waal Malefyt, Merck Research Labs, USA
The Role of TSLP in Allergic Inflammation

Monday, February 14 | 5:00PM - 7:00PM
Type II and Other Cytokines
Room: Anasazi Ballroom

Speaker 2 of 4
Sergei V. Kotenko, New Jersey Medical School, USA
Class II Cytokine Receptors and Their Ligands: Diversities and Similarities

Monday, February 14 | 5:00PM - 7:00PM
Type II and Other Cytokines
Room: Anasazi Ballroom

Speaker 3 of 4
Kevin Klucher, ZymoGenetics, Inc., USA
Short Talk: IL 28/29

Monday, February 14 | 5:00PM - 7:00PM
Type II and Other Cytokines
Room: Anasazi Ballroom

Speaker 4 of 4
Tomohiro Yoshimoto, Hyogo College of Medicine, Japan
Short Talk: IL-18-Stimulated Th1 Cells Induce Allergic Asthma

Monday, February 14 | 7:00PM - 8:00PM
Social Hour
Room: Eldorado Court/Sunset Room


Monday, February 14 | 7:30PM - 10:00PM
Poster Session 2
Room: Sunset Room


Tuesday, February 15 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Tuesday, February 15 | 8:00AM - 11:00AM
Cytokines and Disease Pathogenesis
Room: Anasazi Ballroom

Speaker 1 of 5
Thomas A. Wynn, Pfizer, USA
Opposing Roles for IL-13 and its Decoy Receptor in Health and Disease

Tuesday, February 15 | 8:00AM - 11:00AM
Cytokines and Disease Pathogenesis
Room: Anasazi Ballroom

Speaker 2 of 5
* Christine A. Biron, Brown University, USA
Cytokines and Viral Immunity

Tuesday, February 15 | 8:00AM - 11:00AM
Cytokines and Disease Pathogenesis
Room: Anasazi Ballroom

Speaker 3 of 5
Jean-Laurent Casanova, Rockefeller University, USA
A Genetic Dissection of Cytokine-Mediated Immunity to Infection in Humans

Tuesday, February 15 | 8:00AM - 11:00AM
Cytokines and Disease Pathogenesis
Room: Anasazi Ballroom

Speaker 4 of 5
Robert D. Schreiber, Washington University School of Medicine, USA
The Molecular and Cellular Basis of Cancer Immunosurveillance and Immunoediting

Tuesday, February 15 | 8:00AM - 11:00AM
Cytokines and Disease Pathogenesis
Room: Anasazi Ballroom

Speaker 5 of 5
Mette Ejrnaes, La Jolla Institute for Allergy and Immunology, USA
Short Talk: IL-21 in Models of Acute and Chronic LCMV Infection

Tuesday, February 15 | 9:20AM - 9:40AM
Coffee Break
Room: South Concourse


Tuesday, February 15 | 11:00AM - 1:00PM
Poster Setup
Room: Sunset Room


Tuesday, February 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room


Tuesday, February 15 | 3:00PM - 4:45PM
Workshop 2: Targeting Cytokines
Room: Anasazi Ballroom

Speaker 1 of 6
Norihiro Nishimoto, Wakayama Medical University, Japan
Anti-IL-6 Receptor Antibody Therapy for Immunological Diseases

Tuesday, February 15 | 3:00PM - 4:45PM
Workshop 2: Targeting Cytokines
Room: Anasazi Ballroom

Speaker 2 of 6
* Foo Y. Liew, University of Glasgow, UK
Innate Mediators in Autoimmune Disease

Tuesday, February 15 | 3:00PM - 4:45PM
Workshop 2: Targeting Cytokines
Room: Anasazi Ballroom

Speaker 3 of 6
Andrea Keane-Myers, National Institutes of Health, USA
Short Talk: Opposing Roles for IL-21 in Mouse Models of Asthma

Tuesday, February 15 | 3:00PM - 4:45PM
Workshop 2: Targeting Cytokines
Room: Anasazi Ballroom

Speaker 4 of 6
Heni Rachmawati, University of Groningen, Netherlands
Short Talk: Chemically Modified Interleukin-10 (IL-10) with a Liver-Specific Ligand: A New Strategy for the Treatment of Liver Fibrosis with a Therapeutic Cytokine

Tuesday, February 15 | 3:00PM - 4:45PM
Workshop 2: Targeting Cytokines
Room: Anasazi Ballroom

Speaker 5 of 6
Eugene A. Zhukovsky, Boehringer Ingelheim Pharmaceuticals, Inc., USA
Short Talk: Development of Dominant Negative Antagonists of BAFF for the Treatment of Autoimmune Diseases

Tuesday, February 15 | 3:00PM - 4:45PM
Workshop 2: Targeting Cytokines
Room: Anasazi Ballroom

Speaker 6 of 6
Kyle I. Happel, Louisiana State University Health Sciences Center, USA
Short Talk: IL-23 is Critical to Survival during Pulmonary Infection with Klebsiella pneumoniae

Tuesday, February 15 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: South Concourse


Tuesday, February 15 | 5:00PM - 7:00PM
Cytokines in Autoimmunity and Inflammation
Room: Anasazi Ballroom

Speaker 1 of 4
Padraic Fallon, Trinity College Dublin, Ireland
Helminth Modulation of Cytokines: Therapeutic Exploitation

Tuesday, February 15 | 5:00PM - 7:00PM
Cytokines in Autoimmunity and Inflammation
Room: Anasazi Ballroom

Speaker 2 of 4
* Mary Collins, Wyeth Research, USA
IL-21 in Inflammation and Autoimmunity

Tuesday, February 15 | 5:00PM - 7:00PM
Cytokines in Autoimmunity and Inflammation
Room: Anasazi Ballroom

Speaker 3 of 4
Christoph Binder, University of California, San Diego, USA
Cytokines and Cardiovascular Disease

Tuesday, February 15 | 5:00PM - 7:00PM
Cytokines in Autoimmunity and Inflammation
Room: Anasazi Ballroom

Speaker 4 of 4
Jean-Christophe Renauld, Ludwig Institute for Cancer Research, Belgium
Short Talk: Role of IL-13 in the Asthma-Like Phenotype Induced by IL-9 in vivo

Tuesday, February 15 | 7:00PM - 8:00PM
Social Hour
Room: Eldorado Court/Sunset Room


Tuesday, February 15 | 7:30PM - 10:00PM
Poster Session 3
Room: Sunset Room


Wednesday, February 16 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Wednesday, February 16 | 8:00AM - 11:00AM
Targeting Cytokines II
Room: Anasazi Ballroom

Speaker 1 of 6
Trudi M. Veldman, AbbVie, USA
Anti-IL12 Antibody Development and Clinical Trial Data

Wednesday, February 16 | 8:00AM - 11:00AM
Targeting Cytokines II
Room: Anasazi Ballroom

Speaker 2 of 6
Ivan J. Fuss, National Institutes of Health, USA
Anti-Interleukin-12 Antibody Treats Active Crohn’s Disease

Wednesday, February 16 | 8:00AM - 11:00AM
Targeting Cytokines II
Room: Anasazi Ballroom

Speaker 3 of 6
Fabio Martinon, Harvard School of Public Health, USA
Short Talk: NALP3/Cryopyrin Forms an IL-1beta-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

Wednesday, February 16 | 8:00AM - 11:00AM
Targeting Cytokines II
Room: Anasazi Ballroom

Speaker 4 of 6
* Marc Feldmann, University of Oxford, UK
TNF Antagonism and the Treatment of Autoimmune Disease

Wednesday, February 16 | 8:00AM - 11:00AM
Targeting Cytokines II
Room: Anasazi Ballroom

Speaker 5 of 6
Gabor G. Illei, National Institutes of Health, USA
Short Talk: In vivo Blockade of the IL-6 Receptor Interferes with T and B Cell Differentiation and Activation in Patients with Systemic Lupus Erythematosus

Wednesday, February 16 | 8:00AM - 11:00AM
Targeting Cytokines II
Room: Anasazi Ballroom

Speaker 6 of 6
Jonathan Zalevsky, Nektar Therapeutics, USA
Short Talk: Towards a Ligand-Selective TNF Antagonist: Optimization of Dominant-Negative TNF Proteins as Selective Inhibitors of Soluble TNF That Spare Transmembrane TNF in Animal Models of Inflammation and Infection

Wednesday, February 16 | 9:20AM - 9:40AM
Coffee Break
Room: South Concourse


Wednesday, February 16 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: South Concourse


Wednesday, February 16 | 5:00PM - 7:00PM
Regulation of Cytokine Gene Expression
Room: Anasazi Ballroom

Speaker 1 of 3
Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Transcriptional Regulation of Cytokines

Wednesday, February 16 | 5:00PM - 7:00PM
Regulation of Cytokine Gene Expression
Room: Anasazi Ballroom

Speaker 2 of 3
Stephen T. Smale, University of California, Los Angeles, USA
Nucleosome Remodeling and the Regulation of the Immune Response

Wednesday, February 16 | 5:00PM - 7:00PM
Regulation of Cytokine Gene Expression
Room: Anasazi Ballroom

Speaker 3 of 3
* William E. Paul, NIAID, National Institutes of Health, USA
GATA3 and the Regulation of Th2 Function

Wednesday, February 16 | 7:00PM - 8:00PM
Social Hour
Room: Eldorado Court/Sunset Room


Wednesday, February 16 | 8:00PM - 11:00PM
Entertainment
Room: Eldorado Court/Sunset Room


Wednesday, February 16 | 8:00PM - 11:00PM
Cash Bar
Room: Eldorado Court/Sunset Room


Thursday, February 17 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.