Web Desc
Hormonal Regulation of Tumorigenesis
Organizer(s): Nancy L. Weigel, Suzanne A. Fuqua and Donald Tindall
Date: February 20 - 25, 2005
Location: Hyatt Regency Monterey, Monterey, CA, USA
Supported by The Director's Fund
Summary of Meeting:
Steroid hormones are key factors in the development and growth of tumors in hormone dependent tissues including breast and prostate. These cancers are not only two of the most prevalent cancers, but are also second only to lung cancer in deaths from cancer. Thus, there is a great deal of interest in developing methods to block the actions/production of the steroids. The actions of the steroids are mediated by steroid hormone receptors, members of the nuclear receptor family of ligand-activated transcription factors. However, recent and ongoing studies have shown that the type and magnitude of the activities of the receptors is dependent upon the cohort of coactivators, corepressors, and activity of cell signaling pathways in the cell; these factors and their interaction with receptors are potential therapeutic targets. In both breast and prostate cancer, hormone ablation, or anti-hormone therapies are commonly used. However, tumors become resistant to these treatments. Although, it was initially assumed that these tumors had bypassed the requirements for the steroid receptors, there is exciting new data coming from a number of labs indicating that these tumors remain receptor-dependent and that alterations in receptor expression, coregulator expression and/or cell signaling permit the receptors to continue to function. Thus, there is evidence that androgen receptor is activated in tumors that have become resistant to androgen ablation and that some tamoxifen resistant tumors retain estrogen receptor dependence. Consequently, the contribution of steroid receptor action in hormonally regulated tumors is greater than initially realized and raises a new set of questions regarding how to block the receptor activity. The goal of this meeting is to bring together experts in steroid hormone action with experts in hormonal effects in tumorigenesis to address the important questions of the mechanisms by which the hormones and their receptors induce growth of tumors and how these processes can be blocked.
Discounted Abstract Deadline: October 20 2004
Discounted Registration Deadline: December 20 2004
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Wyeth Research Labs
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13-CA112924-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Sunday, February 20 | 3:00PM - 7:30PM
Registration
Room: Regency Foyer


Sunday, February 20 | 6:30PM - 7:30PM
Refreshments
Room: Regency Foyer


Sunday, February 20 | 7:30PM - 8:30PM
Keynote Address
Room: Regency Main

Speaker 1 of 2
* Benita S. Katzenellenbogen, University of Illinois, USA

Sunday, February 20 | 7:30PM - 8:30PM
Keynote Address
Room: Regency Main

Speaker 2 of 2
Bert W. O'Malley, Baylor College of Medicine, USA
Coactivators and Tissue Specific Responses to Nuclear Receptors

Monday, February 21 | 7:00AM - 8:00AM
Breakfast
Room: Regency 1 - 3


Monday, February 21 | 8:00AM - 11:00AM
Nuclear Receptor Action
Room: Regency Main

Speaker 1 of 6
* Nancy Lynn Weigel, Baylor College of Medicine, USA

Monday, February 21 | 8:00AM - 11:00AM
Nuclear Receptor Action
Room: Regency Main

Speaker 2 of 6
Myles Brown, Dana-Farber Cancer Institute, USA
Chromosome Scall Analysis of ER Action

Monday, February 21 | 8:00AM - 11:00AM
Nuclear Receptor Action
Room: Regency Main

Speaker 3 of 6
Keith R. Yamamoto, University of California, San Francisco, USA
The Dissecting of Regulatory Networks in Seeking Ligands

Monday, February 21 | 8:00AM - 11:00AM
Nuclear Receptor Action
Room: Regency Main

Speaker 4 of 6
Elizabeth M. Wilson, University of North Carolina at Chapel Hill, USA
A Novel Coregulator of Androgen Receptor Transactivation Binds the AR NH2-Terminal FXXLF Motif

Monday, February 21 | 8:00AM - 11:00AM
Nuclear Receptor Action
Room: Regency Main

Speaker 5 of 6
Donald P. McDonnell, Duke University School of Medicine, USA
Orphan Nuclear Receptors as Targets for Drug Discovery in Breast Cancer

Monday, February 21 | 8:00AM - 11:00AM
Nuclear Receptor Action
Room: Regency Main

Speaker 6 of 6
Michael J. Garabedian, New York University School of Medicine, USA
Short Talk: Role of the Hsp90 Cochaperone p23 in ER-Dependent Gene Expression, Cell Adhesion and Angiogenesis in Breast Cancer Cells

Monday, February 21 | 9:20AM - 9:40AM
Coffee Break
Room: Regency Foyer


Monday, February 21 | 11:00AM - 1:00PM
Poster Setup
Room: Regency 1-3


Monday, February 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Regency 1-3


Monday, February 21 | 2:00PM - 4:00PM
Workshop 1: Regulation of Tumor Cell Growth
Room: Regency Main

Speaker 1 of 9
* Daniel Medina, Baylor College of Medicine, USA

Monday, February 21 | 2:00PM - 4:00PM
Workshop 1: Regulation of Tumor Cell Growth
Room: Regency Main

Speaker 2 of 9
Alexander Yemelyanov, Northwestern University, USA
Expression and Function of Glucocorticoid Receptor in Prostate Carcinomas and PC Cells

Monday, February 21 | 2:00PM - 4:00PM
Workshop 1: Regulation of Tumor Cell Growth
Room: Regency Main

Speaker 3 of 9
Zhengying Wang, University of Miami, USA
Vitamin D3 Inhibits Cancer Cell Proliferation through Nuclear Exclusion and Decreased Activity of Cyclin-Dependent Kinase 2

Monday, February 21 | 2:00PM - 4:00PM
Workshop 1: Regulation of Tumor Cell Growth
Room: Regency Main

Speaker 4 of 9
Chao Li, Baylor College of Medicine, USA
Regulation of SRC3/AIB1 by Turnover

Monday, February 21 | 2:00PM - 4:00PM
Workshop 1: Regulation of Tumor Cell Growth
Room: Regency Main

Speaker 5 of 9
Amy H. Bouton, University of Virginia School of Medicine, USA
Src-p130Cas Interactions Regulate Estrogen Dependence and Antiestrogen Resistance of Breast Cancer Cells

Monday, February 21 | 2:00PM - 4:00PM
Workshop 1: Regulation of Tumor Cell Growth
Room: Regency Main

Speaker 6 of 9
Åsa Kronblad, Malmö University Hospital, Sweden
ERK1/2 Inhibition Increases Anti-Estrogen Treatment Efficacy by Prevention of Hypoxia-Induced Down-Regulation of ER-alpha. A Combination Therapy Potentially Targeting Hypoxic and Dormant Tumor Cells

Monday, February 21 | 2:00PM - 4:00PM
Workshop 1: Regulation of Tumor Cell Growth
Room: Regency Main

Speaker 7 of 9
Yun Zhu, Emory University School of Medicine, USA
The SDF1/CXCR4 Axis Mediates Estrogen Independence and Tumor Progression in Breast and Ovarian Cancer

Monday, February 21 | 2:00PM - 4:00PM
Workshop 1: Regulation of Tumor Cell Growth
Room: Regency Main

Speaker 8 of 9
Deborah A. Lannigan, University of Virginia, USA
Identification of the First RSK-Specific Inhibitor Reveals an Unexpected Role for RSK in Breast Cancer Cell Proliferation

Monday, February 21 | 2:00PM - 4:00PM
Workshop 1: Regulation of Tumor Cell Growth
Room: Regency Main

Speaker 9 of 9
Glendon M. Zinser, University of Notre Dame, USA
Vitamin D3 and Wnt/Beta-Catenin Crosstalk during Mammary Gland Transformation

Monday, February 21 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Regency Foyer


Monday, February 21 | 5:00PM - 7:00PM
Inhibitors of Steroid Metabolism and Steroid Hormone Action
in Hormone Dependent Cancer

Room: Regency Main

Speaker 1 of 5
* Shuk-Mei Ho, University of Massachusetts Medical Center, USA

Monday, February 21 | 5:00PM - 7:00PM
Inhibitors of Steroid Metabolism and Steroid Hormone Action
in Hormone Dependent Cancer

Room: Regency Main

Speaker 2 of 5
Carole R. Mendelson, University of Texas Southwestern Medical Center, USA
Mechanisms in the Regulation of Aromatase Expression in Breast Cancer

Monday, February 21 | 5:00PM - 7:00PM
Inhibitors of Steroid Metabolism and Steroid Hormone Action
in Hormone Dependent Cancer

Room: Regency Main

Speaker 3 of 5
Mitchell Dowsett, Royal Marsden, UK
Clinical Use of Aromatase Inhibitors

Monday, February 21 | 5:00PM - 7:00PM
Inhibitors of Steroid Metabolism and Steroid Hormone Action
in Hormone Dependent Cancer

Room: Regency Main

Speaker 4 of 5
Craig J. Burd, Ohio State University, USA
Short Talk: Cyclin D1 Blocks Androgen Receptor Activity in Prostatic Adenocarcinoma

Monday, February 21 | 5:00PM - 7:00PM
Inhibitors of Steroid Metabolism and Steroid Hormone Action
in Hormone Dependent Cancer

Room: Regency Main

Speaker 5 of 5
Martin P. Tenniswood, University at Albany, USA
Short Talk: Differential Acetylation of Androgen Receptor (AR) and p53 by HDAC Inhibitors and Downstream Target Activation in LNCaP Prostate Cancer Cells

Monday, February 21 | 7:00PM - 8:00PM
Social Hour
Room: Regency 1-3


Monday, February 21 | 7:30PM - 10:00PM
Poster Session 1: Coregulators and Nuclear Receptors 1; Mark
ers; Clinical Studies; Steroid Metabolism
Room: Regency 1-3


Tuesday, February 22 | 7:00AM - 8:00AM
Breakfast
Room: Regency 1 - 3


Tuesday, February 22 | 8:00AM - 11:00AM
Hormonal Carcinogenesis
Room: Regency Main

Speaker 1 of 5
* Powel H. Brown, Baylor College of Medicine, USA

Tuesday, February 22 | 8:00AM - 11:00AM
Hormonal Carcinogenesis
Room: Regency Main

Speaker 2 of 5
Shuk-Mei Ho, University of Massachusetts Medical Center, USA
Epigenetic Regulation of Estrogen Receptor-beta Expression and Prostate Carcinogenesis

Tuesday, February 22 | 8:00AM - 11:00AM
Hormonal Carcinogenesis
Room: Regency Main

Speaker 3 of 5
Daniel Medina, Baylor College of Medicine, USA
Protective Effects of Steroids in Breast Cancer

Tuesday, February 22 | 8:00AM - 11:00AM
Hormonal Carcinogenesis
Room: Regency Main

Speaker 4 of 5
Ercole L. Cavalieri, University of Nebraska, USA
Catechol Quinones in the Initiation of Cancer and Other Diseases: A Target for Prevention

Tuesday, February 22 | 8:00AM - 11:00AM
Hormonal Carcinogenesis
Room: Regency Main

Speaker 5 of 5
John A. McLachlan, Tulane University, USA
Endocrine Disrupters: A Case of Environmental Epigenetics

Tuesday, February 22 | 9:20AM - 9:40AM
Coffee Break
Room: Regency Foyer


Tuesday, February 22 | 11:00AM - 1:00PM
Poster Setup
Room: Regency 1-3


Tuesday, February 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Regency 1-3


Tuesday, February 22 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Regency Foyer


Tuesday, February 22 | 5:00PM - 7:00PM
Nuclear Receptors and Inhibition of Tumor Growth
Room: Regency Main

Speaker 1 of 5
* Leonard P. Freedman, Global Biological Standards Institute, USA

Tuesday, February 22 | 5:00PM - 7:00PM
Nuclear Receptors and Inhibition of Tumor Growth
Room: Regency Main

Speaker 2 of 5
Nancy Lynn Weigel, Baylor College of Medicine, USA
Regulation of Prostate Tumor Growth by Vitamin D

Tuesday, February 22 | 5:00PM - 7:00PM
Nuclear Receptors and Inhibition of Tumor Growth
Room: Regency Main

Speaker 3 of 5
JoEllen Welsh, University of New York, Albany, USA
VDR Signaling in Mammary Gland Development and Carcinogenesis in VDR Knockout Mice

Tuesday, February 22 | 5:00PM - 7:00PM
Nuclear Receptors and Inhibition of Tumor Growth
Room: Regency Main

Speaker 4 of 5
Powel H. Brown, Baylor College of Medicine, USA
Chemoprevention in Breast Cancer: Targeting Retinoid Receptors

Tuesday, February 22 | 5:00PM - 7:00PM
Nuclear Receptors and Inhibition of Tumor Growth
Room: Regency Main

Speaker 5 of 5
Anna Abella, INSERM, France
Short Talk: PPARgamma Agonists and HDAC Inhibitors Synergistically Inhibit Prostate Tumor Cell Growth

Tuesday, February 22 | 7:00PM - 8:00PM
Social Hour
Room: Regency 1-3


Tuesday, February 22 | 7:30PM - 10:00PM
Poster Session 2: Signaling and Growth Factors; Hormone Inde
pendence and Metastasis; Gene Regulation/Expression
Room: Regency 1-3


Wednesday, February 23 | 7:00AM - 8:00AM
Breakfast
Room: Regency 1 - 3


Wednesday, February 23 | 8:00AM - 11:00AM
Estrogen Receptors and Cross-Talk with Cell Signaling Pathwa
ys

Room: Regency Main

Speaker 1 of 6
* Carole R. Mendelson, University of Texas Southwestern Medical Center, USA

Wednesday, February 23 | 8:00AM - 11:00AM
Estrogen Receptors and Cross-Talk with Cell Signaling Pathwa
ys

Room: Regency Main

Speaker 2 of 6
Benita S. Katzenellenbogen, University of Illinois, USA
Breast Cancer Regulation by Estrogen Receptors Alpha and Beta and Coregulators

Wednesday, February 23 | 8:00AM - 11:00AM
Estrogen Receptors and Cross-Talk with Cell Signaling Pathwa
ys

Room: Regency Main

Speaker 3 of 6
Carlos L. Arteaga, Vanderbilt University School of Medicine, USA
HER2/neu (erbB2) Signaling and Antiestrogen Resistance in Human Breast Cancer


Wednesday, February 23 | 8:00AM - 11:00AM
Estrogen Receptors and Cross-Talk with Cell Signaling Pathwa
ys

Room: Regency Main

Speaker 4 of 6
Suzanne AW Fuqua, Baylor College of Medicine, USA
Crosstalk between Estrogen Receptor alpha and Signal Transduction Networks

Wednesday, February 23 | 8:00AM - 11:00AM
Estrogen Receptors and Cross-Talk with Cell Signaling Pathwa
ys

Room: Regency Main

Speaker 5 of 6
Ellis R. Levin, University of California, Irvine, USA
Extranuclear Action of ER in Breast Cancer

Wednesday, February 23 | 8:00AM - 11:00AM
Estrogen Receptors and Cross-Talk with Cell Signaling Pathwa
ys

Room: Regency Main

Speaker 6 of 6
Leslie C. Hodges, University of California, San Francisco, USA
Short Talk: Estrogen Receptor Pathways to Proliferation in the Mammary Gland

Wednesday, February 23 | 9:20AM - 9:40AM
Coffee Break
Room: Regency Foyer


Wednesday, February 23 | 11:00AM - 1:00PM
Poster Setup
Room: Regency 1-3


Wednesday, February 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Regency 1-3


Wednesday, February 23 | 2:00PM - 4:00PM
Workshop 2: Nuclear Receptors and their Coregulators
Room: Regency Main

Speaker 1 of 8
* Wayne D. Tilley, University of Adelaide, Australia

Wednesday, February 23 | 2:00PM - 4:00PM
Workshop 2: Nuclear Receptors and their Coregulators
Room: Regency Main

Speaker 2 of 8
ZhaoYi Wang, Creighton University, USA
A Novel Variant of Estrogen Receptor-Alpha is Expressed in ER-Negative Breast Cancer and Mediates Membrane-Initiated Estrogen Signaling

Wednesday, February 23 | 2:00PM - 4:00PM
Workshop 2: Nuclear Receptors and their Coregulators
Room: Regency Main

Speaker 3 of 8
Virgilio A. Salvo, Tulane University, USA
MEK5-Erk5 Signaling Promotes Estrogen-Independent Tumorigenesis of Breast Carcinoma Cells

Wednesday, February 23 | 2:00PM - 4:00PM
Workshop 2: Nuclear Receptors and their Coregulators
Room: Regency Main

Speaker 4 of 8
Fuzhong Zheng, Baylor College of Medicine, USA
Estrogen Receptor Mediates the Estradiol-Induced Phosphorylation of SRC-3

Wednesday, February 23 | 2:00PM - 4:00PM
Workshop 2: Nuclear Receptors and their Coregulators
Room: Regency Main

Speaker 5 of 8
Irina Agoulnik, Florida International University College of Medicine, USA
Short Talk: A Role for Tif2 in Emergence of Aggressive Prostate Cancers after Androgen Ablation

Wednesday, February 23 | 2:00PM - 4:00PM
Workshop 2: Nuclear Receptors and their Coregulators
Room: Regency Main

Speaker 6 of 8
Catherine K. Yang, University of Southern California, USA
Synergistic Effects of Beta-Catenin and Nuclear Receptor Coactivator CoCoA

Wednesday, February 23 | 2:00PM - 4:00PM
Workshop 2: Nuclear Receptors and their Coregulators
Room: Regency Main

Speaker 7 of 8
Hong-Wu Chen, University of California, Davis, USA
Androgen Receptor and the p160/SRC Coactivators Control Prostate Cancer Cell Proliferation via Distinct Mechanisms

Wednesday, February 23 | 2:00PM - 4:00PM
Workshop 2: Nuclear Receptors and their Coregulators
Room: Regency Main

Speaker 8 of 8
Sung Hee Baek, Seoul National University, South Korea
Roles of Nuclear Receptor Coregulators to Regulate Metastasis Suppressor Genes in Prostate Cancer

Wednesday, February 23 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Regency Foyer


Wednesday, February 23 | 5:00PM - 7:00PM
Androgen Action in Prostate Cancer
Room: Regency Main

Speaker 1 of 4
* Charles L. Sawyers, Memorial Sloan-Kettering Cancer Center, USA

Wednesday, February 23 | 5:00PM - 7:00PM
Androgen Action in Prostate Cancer
Room: Regency Main

Speaker 2 of 4
Donald J. Tindall, Mayo Clinic and Foundation, USA
Androgen Regulation of the Growth and Survival of Prostate Cancer Cells

Wednesday, February 23 | 5:00PM - 7:00PM
Androgen Action in Prostate Cancer
Room: Regency Main

Speaker 3 of 4
Johannes V. Swinnen, KU Leuven, Belgium
Androgenic Regulation of Lipogenic Gene Expression in Prostate Cancer

Wednesday, February 23 | 5:00PM - 7:00PM
Androgen Action in Prostate Cancer
Room: Regency Main

Speaker 4 of 4
Michael B. Cohen, University of Iowa, USA
Short Talk: Androgen Regulation of TNFR Family-Induced Apoptosis

Wednesday, February 23 | 7:00PM - 8:00PM
Social Hour
Room: Regency 1-3


Wednesday, February 23 | 7:30PM - 10:00PM
Poster Session 3: Coregulators and Nuclear Receptors 2; Cell
/Tumor Growth/Apoptosis
Room: Regency 1-3


Thursday, February 24 | 7:00AM - 8:00AM
Breakfast
Room: Regency 1 - 3


Thursday, February 24 | 8:00AM - 11:15AM
Androgen Receptors and Cross-Talk with Cell Signaling Pathwa
ys

Room: Regency Main

Speaker 1 of 7
* Donald J. Tindall, Mayo Clinic and Foundation, USA

Thursday, February 24 | 8:00AM - 11:15AM
Androgen Receptors and Cross-Talk with Cell Signaling Pathwa
ys

Room: Regency Main

Speaker 2 of 7
Wayne D. Tilley, University of Adelaide, Australia
Androgen Receptor in Prostate Cancer Development and Progression

Thursday, February 24 | 8:00AM - 11:15AM
Androgen Receptors and Cross-Talk with Cell Signaling Pathwa
ys

Room: Regency Main

Speaker 3 of 7
Charles L. Sawyers, Memorial Sloan-Kettering Cancer Center, USA
Mechanisms of Hormone Refractory Prostate Cancer

Thursday, February 24 | 8:00AM - 11:15AM
Androgen Receptors and Cross-Talk with Cell Signaling Pathwa
ys

Room: Regency Main

Speaker 4 of 7
Duane D. Miller, University of Tennessee Health Science Center, USA
SARMS- Biology and Chemistry

Thursday, February 24 | 8:00AM - 11:15AM
Androgen Receptors and Cross-Talk with Cell Signaling Pathwa
ys

Room: Regency Main

Speaker 5 of 7
Neal Rosen, Memorial Sloan-Kettering Cancer Center, USA
MAPK Signaling in Cancer

Thursday, February 24 | 8:00AM - 11:15AM
Androgen Receptors and Cross-Talk with Cell Signaling Pathwa
ys

Room: Regency Main

Speaker 6 of 7
Gerhard A. Coetzee, University of Southern California, USA
Short Talk: AR-Mediated Conversion of Androgen Ablation Sensitive to –Insensitive Cells

Thursday, February 24 | 8:00AM - 11:15AM
Androgen Receptors and Cross-Talk with Cell Signaling Pathwa
ys

Room: Regency Main

Speaker 7 of 7
Shan Lu, University of Cincinnati School of Medicine, USA
Short Talk: PI3K-Akt Signaling Pathway is Critical for Androgen-Independent Growth in Prostate Cancer Cells

Thursday, February 24 | 9:20AM - 9:40AM
Coffee Break
Room: Regency Foyer


Thursday, February 24 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Regency Foyer


Thursday, February 24 | 5:00PM - 7:00PM
Steroids and Cancer
Room: Regency Main

Speaker 1 of 5
* Suzanne AW Fuqua, Baylor College of Medicine, USA

Thursday, February 24 | 5:00PM - 7:00PM
Steroids and Cancer
Room: Regency Main

Speaker 2 of 5
Jan-Åke Gustafsson, University of Houston, USA
Antiproliferative Actions of ERbeta

Thursday, February 24 | 5:00PM - 7:00PM
Steroids and Cancer
Room: Regency Main

Speaker 3 of 5
Leonard P. Freedman, Global Biological Standards Institute, USA
Mechanisms of Action of ERalpha - Selective Agents

Thursday, February 24 | 5:00PM - 7:00PM
Steroids and Cancer
Room: Regency Main

Speaker 4 of 5
Patricia V. Elizalde, Instituto de Biología y Medicina Experimental, Argentina
Progesterone Action in Breast Cancer Cells

Thursday, February 24 | 5:00PM - 7:00PM
Steroids and Cancer
Room: Regency Main

Speaker 5 of 5
Jianming Xu, Baylor College of Medicine, USA
Short Talk: Dual Role of the Cancer-Amplified Coactivator AIB3 in Mammary Gland Development and Tumorigenesis

Thursday, February 24 | 7:00PM - 8:00PM
Social Hour
Room: Regency Foyer


Thursday, February 24 | 8:00PM - 11:00PM
Entertainment
Room: Regency Main


Thursday, February 24 | 8:00PM - 11:00PM
Cash Bar
Room: Regency Main


Friday, February 25 | 10:26AM - 10:26AM
Departure


*Session Chair.