Web Desc
Ubiquitin and Signaling
Organizer(s): Tony Hunter, Claudio Joazeiro and Mark Hochstrasser
Date: February 22 - 27, 2005
Location: Taos Convention Center (meeting only), Taos, New Mexico, USA
Supported by The Director's Fund
For important information on the coronavirus, please click here
Summary of Meeting:
Our understanding of how ubiquitin regulates cellular function has greatly expanded recently, spurred by discoveries of protein families involved in ubiquitin conjugation and de-conjugation and of non-proteasomal signaling functions for ubiquitin. Ubiquitin regulates an enormous range of cellular processes. There are almost as many predicted human ubiquitin ligases as protein kinases, and the ubiquitin system has been directly implicated in various diseases, including many cancers and neurodegenerative disorders. Many protein domains have recently been associated with ubiquitination, deubiquitination or ubiquitin binding. These are found in several thousand proteins; the challenge is to determine their functions and mechanistic links to the ubiquitin system. The goal of the meeting is to bring together experts from different areas of ubiquitin research, as well as experts from other fields that are beginning to be affected by our knowledge of ubiquitin function. We expect that this meeting will foster extensive discussion of ubiquitin system function in both normal and pathological states.
Discounted Abstract Deadline: October 21 2004
Discounted Registration Deadline: December 22 2004
We gratefully acknowledge additional support for this conference from:
Celgene CorporationCell Signaling Technology, Inc.Educational grant from Millennium Pharmaceuticals, Inc., The Takeda Oncology CompanyGlobal Peptide ServicesNovartis Institutes for BioMedical Research
Proteome Resources LLC
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Regeneron Pharmaceuticals, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, February 22 | 3:00PM - 7:30PM
Registration
Room: Rio Grande D


Tuesday, February 22 | 6:30PM - 7:30PM
Refreshments
Room: Rio Grande A-C


Tuesday, February 22 | 7:30PM - 8:30PM
Keynote Address
Room: Bataan

Speaker 1 of 1
Cecile M. Pickart, Johns Hopkins University, USA
Assembly and Recognition of Polyubiquitin Signals

Wednesday, February 23 | 7:00AM - 8:00AM
Breakfast
Room: Rio Grande A/B/C


Wednesday, February 23 | 8:00AM - 11:15AM
E3 Ubiquitin Ligases: Function and Substrate Recognition I
Room: Bataan

Speaker 1 of 7
* Daniel J. Finley, Harvard University, USA

Wednesday, February 23 | 8:00AM - 11:15AM
E3 Ubiquitin Ligases: Function and Substrate Recognition I
Room: Bataan

Speaker 2 of 7
Alexander Varshavsky, California Institute of Technology, USA
The Functions of the N-End Rule Pathway

Wednesday, February 23 | 8:00AM - 11:15AM
E3 Ubiquitin Ligases: Function and Substrate Recognition I
Room: Bataan

Speaker 3 of 7
William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA
Two SCF-Like Ubiquitin Ligases Linked to Cancer

Wednesday, February 23 | 8:00AM - 11:15AM
E3 Ubiquitin Ligases: Function and Substrate Recognition I
Room: Bataan

Speaker 4 of 7
Gina D. Visser, University of Iowa, Carver College of Medicine, USA
Short Talk: c-Cbl RING Finger Tail Sequences are Critical Determinants of EGF Receptor and Sprouty2 Fate

Wednesday, February 23 | 8:00AM - 11:15AM
E3 Ubiquitin Ligases: Function and Substrate Recognition I
Room: Bataan

Speaker 5 of 7
Cam Patterson, University of North Carolina at Chapel Hill, USA
CHIP and Degradation of Unfolded Proteins

Wednesday, February 23 | 8:00AM - 11:15AM
E3 Ubiquitin Ligases: Function and Substrate Recognition I
Room: Bataan

Speaker 6 of 7
Kathleen L. Gould, Vanderbilt University, USA
Structure of APC and U box E3s

Wednesday, February 23 | 8:00AM - 11:15AM
E3 Ubiquitin Ligases: Function and Substrate Recognition I
Room: Bataan

Speaker 7 of 7
Peter S. Brzovic, University of Washington, USA
Short Talk: NMR Investigations of BRCA1-Directed Ubiquitination: Assembly and Structure of a Multi-Protein Ubiquitin Ligase Complex

Wednesday, February 23 | 9:20AM - 9:40AM
Coffee Break
Room: Rio Grande C/D


Wednesday, February 23 | 11:15AM - 1:00PM
Poster Setup
Room: Rio Grande


Wednesday, February 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Rio Grande


Wednesday, February 23 | 4:30PM - 4:45PM
Coffee & Snacks Available
Room: Foyer


Wednesday, February 23 | 4:45PM - 7:00PM
E3 Ubiquitin Ligases: Function and Substrate Recognition II
Room: Bataan

Speaker 1 of 6
* Dong-Er Zhang, Regents of the University of California, San Diego, USA

Wednesday, February 23 | 4:45PM - 7:00PM
E3 Ubiquitin Ligases: Function and Substrate Recognition II
Room: Bataan

Speaker 2 of 6
Claudio A. P. Joazeiro, University of Heidelberg, Germany
Functional Genomics of Ubiquitin Ligases

Wednesday, February 23 | 4:45PM - 7:00PM
E3 Ubiquitin Ligases: Function and Substrate Recognition II
Room: Bataan

Speaker 3 of 6
Kim D. Finley, San Diego State University, USA
Short Talk: Defects in Autophagy and Clearance of Ubiquitinated-Proteins are Associated with Progressive Neural Degeneration in Drosophila

Wednesday, February 23 | 4:45PM - 7:00PM
E3 Ubiquitin Ligases: Function and Substrate Recognition II
Room: Bataan

Speaker 4 of 6
Keiji Tanaka, Tokyo Metropolitan Institute of Medical Science, Japan
Recognition of Glycosylated Substrates by SCF(Fbs) Ubiquitin Ligases

Wednesday, February 23 | 4:45PM - 7:00PM
E3 Ubiquitin Ligases: Function and Substrate Recognition II
Room: Bataan

Speaker 5 of 6
Raymond J. Deshaies, Amgen, Inc., USA
Quantitative Mass Spectrometry for Identification of Targets in the Proteasome Ubiquitin System

Wednesday, February 23 | 4:45PM - 7:00PM
E3 Ubiquitin Ligases: Function and Substrate Recognition II
Room: Bataan

Speaker 6 of 6
Jian Hu, University of North Carolina at Chapel Hill, USA
Short Talk: Targeted Ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 Ligase in Response to DNA Damage

Wednesday, February 23 | 7:00PM - 8:00PM
Social Hour
Room: Rio Grande


Wednesday, February 23 | 7:30PM - 10:00PM
Poster Session 1
Room: Rio Grande


Thursday, February 24 | 7:00AM - 8:00AM
Breakfast
Room: Rio Grande A/B/C


Thursday, February 24 | 8:00AM - 11:00AM
Deubiquitinating Enzymes
Room: Bataan

Speaker 1 of 7
* Raymond J. Deshaies, Amgen, Inc., USA

Thursday, February 24 | 8:00AM - 11:00AM
Deubiquitinating Enzymes
Room: Bataan

Speaker 2 of 7
Keith D. Wilkinson, Emory University, USA
Tools for Analyses of Deubiquitinating Enzymes

Thursday, February 24 | 8:00AM - 11:00AM
Deubiquitinating Enzymes
Room: Bataan

Speaker 3 of 7
Kim Orth, University of Texas Southwestern Medical Center, USA
Short Talk: Biochemical and Structural Characterization of the Effector Protein XopD

Thursday, February 24 | 8:00AM - 11:00AM
Deubiquitinating Enzymes
Room: Bataan

Speaker 4 of 7
Robert E. Cohen, University of Iowa, USA
Proteasome-Associated Deubiquitination

Thursday, February 24 | 8:00AM - 11:00AM
Deubiquitinating Enzymes
Room: Bataan

Speaker 5 of 7
Sebastian M. B. Nijman, CeMM, Austrian Academy of Sciences, Austria
Functional Annotation of Deubiquitinating Enzymes Using RNA Interference

Thursday, February 24 | 8:00AM - 11:00AM
Deubiquitinating Enzymes
Room: Bataan

Speaker 6 of 7
Greg Odorizzi, University of Colorado, USA
Short Talk: The Ubiquitin Thiolesterase Doa4 Controls Vesicle Size in Multivesicular Bodies in Yeast

Thursday, February 24 | 8:00AM - 11:00AM
Deubiquitinating Enzymes
Room: Bataan

Speaker 7 of 7
Christopher P. Hill, University of Utah, USA
Proteasome Activation

Thursday, February 24 | 9:20AM - 9:40AM
Coffee Break
Room: Rio Grande C/D


Thursday, February 24 | 11:00AM - 1:00PM
Poster Setup
Room: Rio Grande


Thursday, February 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Rio Grande


Thursday, February 24 | 4:30PM - 4:45PM
Coffee & Snacks Available
Room: Foyer


Thursday, February 24 | 4:45PM - 7:00PM
Ubiquitin-Like Proteins
Room: Bataan

Speaker 1 of 6
* Keith D. Wilkinson, Emory University, USA

Thursday, February 24 | 4:45PM - 7:00PM
Ubiquitin-Like Proteins
Room: Bataan

Speaker 2 of 6
Dong-Er Zhang, Regents of the University of California, San Diego, USA
ISG15-Specific Isopeptidase UBP43 and Protein ISGylation

Thursday, February 24 | 4:45PM - 7:00PM
Ubiquitin-Like Proteins
Room: Bataan

Speaker 3 of 6
Chen Zhao, University of Texas at Austin, USA
Short Talk: The Human ISD15 Conjugation System Targets both Interferon Induced and Constitutive Espressed Proteins in Diverse Cellular Pathways

Thursday, February 24 | 4:45PM - 7:00PM
Ubiquitin-Like Proteins
Room: Bataan

Speaker 4 of 6
Frauke Melchior, Universität Heidelberg, Germany
Postranslational Modification with Ubiquitin Related Proteins of the SUMO Family

Thursday, February 24 | 4:45PM - 7:00PM
Ubiquitin-Like Proteins
Room: Bataan

Speaker 5 of 6
David Reverter, Sloan-Kettering Institute, USA
Short Talk: Structure and Analysis of an Ubl-Substrate-E2-E3 Complex between SUMO, RanGAP1, Ubc9, and Nup358/RanBP2

Thursday, February 24 | 4:45PM - 7:00PM
Ubiquitin-Like Proteins
Room: Bataan

Speaker 6 of 6
Brenda A. Schulman, Max Planck Institute of Biochemistry, Germany
Structural and Mechanistic Insights into the Nedd8 Conjugation Cascade

Thursday, February 24 | 7:00PM - 8:00PM
Social Hour
Room: Rio Grande


Thursday, February 24 | 7:30PM - 10:00PM
Poster Session 2
Room: Rio Grande


Friday, February 25 | 7:00AM - 8:00AM
Breakfast
Room: Rio Grande A/B/C


Friday, February 25 | 8:00AM - 11:15AM
Non-Proteasomal Functions of Ubiquitin I: Membrane Trafficki
ng

Room: Bataan

Speaker 1 of 7
* Wesley I. Sundquist, University of Utah School of Medicine, USA

Friday, February 25 | 8:00AM - 11:15AM
Non-Proteasomal Functions of Ubiquitin I: Membrane Trafficki
ng

Room: Bataan

Speaker 2 of 7
Linda Hicke, Northwestern University, USA
Regulation of Receptor Endocytosis by Monoubiquitin Signals

Friday, February 25 | 8:00AM - 11:15AM
Non-Proteasomal Functions of Ubiquitin I: Membrane Trafficki
ng

Room: Bataan

Speaker 3 of 7
Simona Polo, FIRC Institute of Molecular Oncology, Italy
Ubiquitination Directs Clathrin-Independent Internalization

Friday, February 25 | 8:00AM - 11:15AM
Non-Proteasomal Functions of Ubiquitin I: Membrane Trafficki
ng

Room: Bataan

Speaker 4 of 7
James H. Hurley, University of California, Berkeley, USA
Structural Mechanisms for Intracellular Sorting of Monoubiquitinated Membrane Proteins

Friday, February 25 | 8:00AM - 11:15AM
Non-Proteasomal Functions of Ubiquitin I: Membrane Trafficki
ng

Room: Bataan

Speaker 5 of 7
Ivan Dikic, Goethe University Medical School, Germany
Regulation of Ub-Binding Proteins by Monoubiquitination

Friday, February 25 | 8:00AM - 11:15AM
Non-Proteasomal Functions of Ubiquitin I: Membrane Trafficki
ng

Room: Bataan

Speaker 6 of 7
Hsiangling Teo, Nanyang Technological University, Singapore
Short Talk: ESCRT-I and ESCRT-II: Crystal Structures and Interactions

Friday, February 25 | 8:00AM - 11:15AM
Non-Proteasomal Functions of Ubiquitin I: Membrane Trafficki
ng

Room: Bataan

Speaker 7 of 7
Hemmo Meyer, University Duisburg-Essen, Germany
Short Talk: p97/Cdc48 and its Adapters: a Multifunctional Ubiquitin-Dependent Chaperone System

Friday, February 25 | 9:20AM - 9:40AM
Coffee Break
Room: Rio Grande C/D


Friday, February 25 | 11:15AM - 1:00PM
Poster Setup
Room: Rio Grande


Friday, February 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Rio Grande


Friday, February 25 | 4:30PM - 4:45PM
Coffee & Snacks Available
Room: Foyer


Friday, February 25 | 4:45PM - 7:00PM
Non-Proteasomal Functions of Ubiquitin II: The Nucleus
Room: Bataan

Speaker 1 of 5
* Frauke Melchior, Universität Heidelberg, Germany

Friday, February 25 | 4:45PM - 7:00PM
Non-Proteasomal Functions of Ubiquitin II: The Nucleus
Room: Bataan

Speaker 2 of 5
Mary Ann Osley, University of New Mexico School of Medicine, USA
Histone Ubiquitylation: Roles in Transcription Initiation and Elongation

Friday, February 25 | 4:45PM - 7:00PM
Non-Proteasomal Functions of Ubiquitin II: The Nucleus
Room: Bataan

Speaker 3 of 5
Peter Kaiser, University of California, Irvine, USA
Short Talk: Ubiquitination Regulates Several Components of the Met4 Transcription Complex

Friday, February 25 | 4:45PM - 7:00PM
Non-Proteasomal Functions of Ubiquitin II: The Nucleus
Room: Bataan

Speaker 4 of 5
Lijun Sun, University of Texas Southwestern Medical Center, USA
Short Talk: Ubiquitin Signaling in the NF-kappaB Pathway

Friday, February 25 | 4:45PM - 7:00PM
Non-Proteasomal Functions of Ubiquitin II: The Nucleus
Room: Bataan

Speaker 5 of 5
Jonathon Pines, University of Cambridge, UK
Mitosis - What's Ubiquitin Got To Do With It?

Friday, February 25 | 7:00PM - 8:00PM
Social Hour
Room: Rio Grande


Friday, February 25 | 7:30PM - 10:00PM
Poster Session 3
Room: Rio Grande


Saturday, February 26 | 7:00AM - 8:00AM
Breakfast
Room: Rio Grande A/B/C


Saturday, February 26 | 8:00AM - 11:00AM
New Trends
Room: Bataan

Speaker 1 of 7
* Ivan Dikic, Goethe University Medical School, Germany

Saturday, February 26 | 8:00AM - 11:00AM
New Trends
Room: Bataan

Speaker 2 of 7
Daniel J. Finley, Harvard University, USA
Elongation and Disassembly of Multiubiquitin Chains Bound to the Proteasome: Opposing Roles of Ubiquitin-Ligase Hul5 and Deubiquitinating Enzyme Ubp6

Saturday, February 26 | 8:00AM - 11:00AM
New Trends
Room: Bataan

Speaker 3 of 7
Wei Gu, Columbia University, USA
Dissecting the Complexity in the p53-Ubiquitination Pathway

Saturday, February 26 | 8:00AM - 11:00AM
New Trends
Room: Bataan

Speaker 4 of 7
Sudha K. Shenoy, Duke University Medical Center, USA
Regulation of ERK Scaffolding and Signaling by Beta-Arrestin Ubiquitination

Saturday, February 26 | 8:00AM - 11:00AM
New Trends
Room: Bataan

Speaker 5 of 7
Leonard Girnita, Karolinska Institute, Sweden
Short Talk: Insulin-like Growth Factor-1 (IGF-1R) Ubiquitination: Functional Impact on IGF-1R Signaling Pathways

Saturday, February 26 | 8:00AM - 11:00AM
New Trends
Room: Bataan

Speaker 6 of 7
Chris Stefan, University of California, San Diego, USA
Short Talk: Genome-Wide Screening for Membrane Protein Quality

Saturday, February 26 | 8:00AM - 11:00AM
New Trends
Room: Bataan

Speaker 7 of 7
Tom K. Kerppola, University of Michigan, USA
Short Talk: Visualization of Ubiquitination in Living Cells by Ubiquitin-Mediated Fluoresence Complementation

Saturday, February 26 | 9:20AM - 9:40AM
Coffee Break
Room: Rio Grande C/D


Saturday, February 26 | 4:30PM - 4:45PM
Coffee & Snacks Available
Room: Foyer


Saturday, February 26 | 4:45PM - 7:00PM
The Ubiquitin System: Disease and Drug Targets
Room: Bataan

Speaker 1 of 5
* Christopher P. Hill, University of Utah, USA

Saturday, February 26 | 4:45PM - 7:00PM
The Ubiquitin System: Disease and Drug Targets
Room: Bataan

Speaker 2 of 5
David J. Glass, Regeneron Pharmaceuticals, Inc., USA
Signaling Pathways Mediating Skeletal Muscle Hypertrophy and Atrophy

Saturday, February 26 | 4:45PM - 7:00PM
The Ubiquitin System: Disease and Drug Targets
Room: Bataan

Speaker 3 of 5
Wesley I. Sundquist, University of Utah School of Medicine, USA
The Biochemistry of HIV-1 Release

Saturday, February 26 | 4:45PM - 7:00PM
The Ubiquitin System: Disease and Drug Targets
Room: Bataan

Speaker 4 of 5
James Gavin, Takeda Boston, USA
Short Talk: Drug Discovery in the Pathways for Ubiquitin and Ubiquitin-like Protein Conjugation

Saturday, February 26 | 4:45PM - 7:00PM
The Ubiquitin System: Disease and Drug Targets
Room: Bataan

Speaker 5 of 5
Steven P. Gygi, Harvard Medical School, USA
Quantitative Proteomics Strategies for the Study of Protein Ubiquitination

Saturday, February 26 | 7:00PM - 8:00PM
Social Hour
Room: Rio Grande


Saturday, February 26 | 8:00PM - 11:00PM
Entertainment
Room: Rio Grande


Saturday, February 26 | 8:15PM - 11:00PM
Cash Bar
Room: Rio Grande


Sunday, February 27 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.