Web Desc
Inflammation and Cancer
Organizer(s): Raymond N. DuBois and Lisa M. Coussens
Date: February 27 - March 03, 2005
Location: Beaver Run Resort, Breckenridge, CO, USA
Supported by The Director's Fund
Summary of Meeting:
Chronic or recurrent inflammation is responsible for the development of many human cancers, including those affecting the liver, esophagus, stomach, large intestine, and urinary bladder [Coussens and Werb, [2002]]. Inflammation might influence the pathogenesis of cancers by (i) inflicting cell and genome damage, (ii) triggering restorative cell proliferation to replace damaged cells, (iii) elaborating a portfolio of cytokines that promote cell replication, angiogenesis and tissue repair [Coussens and Werb, [2002]]. Oxidative damage to DNA and other cellular components accompanying chronic or recurrent inflammation could increase risk by increasing the mutation rate. In response to infections, inflammatory cells produce a variety of toxic compounds designed to eradicate microorganisms. These include superoxide, hydrogen peroxide, singlet oxygen, as well as nitric oxide that can react further to form the highly reactive peroxynitrite. Some of these reactive oxygen and nitrogen species can directly interact with DNA in the host bystander cells, or react with other cellular components such as lipid, initiating a free radical chain reaction. If the damage is severe, these compounds can kill host bystander cells as well as pathogens, and can produce DNA damage and mutations among host cell survivors. As a consequence of an acquired defect in defenses against oxidant and electrophilic carcinogens associated with CpG island hypermethylation, normal epithelial cells may acquire a heightened susceptibility to oxidative genome damage in an inflammatory milieu, leading to neoplastic transformation and cancer progression.
Discounted Abstract Deadline: October 27 2004
Discounted Registration Deadline: December 27 2004
We gratefully acknowledge additional support for this conference from:
EMD Serono, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 27 | 3:00PM - 7:30PM
Registration
Room: Foyer


Sunday, February 27 | 6:30PM - 7:30PM
Refreshments
Room: Foyer


Sunday, February 27 | 7:30PM - 8:30PM
Keynote Address
Room: Peaks 4-5

Speaker 1 of 1
Harold F. Dvorak, Beth Israel Deaconess Medical Center, USA
Inflammation And Cancer Induce Neovascular Stroma By Common Mechanisms.

Monday, February 28 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Monday, February 28 | 8:00AM - 11:15AM
Innate Immunity and Malignancy
Room: Peaks 4-5

Speaker 6 of 6
Jeffrey W. Pollard, Queen's Medical Research Institute, UK
Tumor-educated macrophages promote mammary tumor progression and metastasis

Monday, February 28 | 8:00AM - 11:15AM
Innate Immunity and Malignancy
Room: Peaks 4-5

Speaker 5 of 6
P. Charles Lin, Vanderbilt University, USA
Short Talk: Expansion of Myeloid Immune Suppressor Gr+CD11b+ Cells in Tumor-bearing Host Directly Promotes Tumor Angiogenesis

Monday, February 28 | 8:00AM - 11:15AM
Innate Immunity and Malignancy
Room: Peaks 4-5

Speaker 4 of 6
* Lisa M. Coussens, Oregon Health & Science University, USA
Innate and Adaptive Immune Interactions Promote Cancer Development

Monday, February 28 | 8:00AM - 11:15AM
Innate Immunity and Malignancy
Room: Peaks 4-5

Speaker 3 of 6
Alison K. Bauer, University of Colorado Anschutz Medical Campus, USA
Short Talk: A Protective Role for Toll-like Receptor (TLR)-4 in Butylated Hydroxytoluene (BHT)-Induced Mouse Pulmonary Inflammation and Tumorigenesis

Monday, February 28 | 8:00AM - 11:15AM
Innate Immunity and Malignancy
Room: Peaks 4-5

Speaker 2 of 6
Frances R. Balkwill, Barts Cancer Institute, Queen Mary University of London, UK
The Role of Inflammatory Cytokines and Chemokines in Cancer Progression

Monday, February 28 | 8:00AM - 11:15AM
Innate Immunity and Malignancy
Room: Peaks 4-5

Speaker 1 of 6
Alberto Mantovani, Humanitas University, Italy
Innate Immunity and Cancer

Monday, February 28 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Monday, February 28 | 11:15AM - 1:00PM
Poster Setup
Room: Peaks 1-3


Monday, February 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-3


Monday, February 28 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Monday, February 28 | 5:00PM - 7:00PM
Inflammatory Stressors and Cancer Progression
Room: Peaks 4-5

Speaker 4 of 4
Kathy Helzlsouer, Johns Hopkins University, USA
C-Reactive Protein Levels and Subsequent Cancer Outcomes: Results from a Prospective Cohort Study and Implications for Prevention

Monday, February 28 | 5:00PM - 7:00PM
Inflammatory Stressors and Cancer Progression
Room: Peaks 4-5

Speaker 3 of 4
William L. Farrar, National Cancer Institute, USA
Short Talk: Interleukin 6 (IL-6) Regulates and maintains Epigenetic Silencing of Tumor Suppressor and DNA Repair Genes in Human Multiple Myeloma Cells

Monday, February 28 | 5:00PM - 7:00PM
Inflammatory Stressors and Cancer Progression
Room: Peaks 4-5

Speaker 2 of 4
* Thea D. Tlsty, University of California, San Francisco, USA
Epigenetic And Genetic Changes Control Tumorigenic Phenotypes and Occur In Vivo in Human Mammary Epithelia

Monday, February 28 | 5:00PM - 7:00PM
Inflammatory Stressors and Cancer Progression
Room: Peaks 4-5

Speaker 1 of 4
Curtis C. Harris, NCI, National Institutes of Health, USA
Radical Causes of Human Cancer


Monday, February 28 | 7:00PM - 8:00PM
Social Hour
Room: Peaks 1-3


Monday, February 28 | 7:30PM - 10:00PM
Poster Session 1
Room: Peaks 1-3


Tuesday, March 01 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Tuesday, March 01 | 8:00AM - 11:00AM
Tumor Immunotherapy
Room: Peaks 4-5

Speaker 3 of 5
Drew M. Pardoll, Johns Hopkins University School of Medicine, USA
Molecular Immunology and Tumor Immunotherapy

Tuesday, March 01 | 8:00AM - 11:00AM
Tumor Immunotherapy
Room: Peaks 4-5

Speaker 2 of 5
Brian P. Dolan, Oregon State University, USA
Short Talk: Dendritic Cells Acquire Functional Peptide-MHC Complexes from Necrotic Tumor Cells

Tuesday, March 01 | 8:00AM - 11:00AM
Tumor Immunotherapy
Room: Peaks 4-5

Speaker 1 of 5
Olivera J. Finn, University of Pittsburgh School of Medicine, USA
Premalignant lesions as targets for cancer vaccines

Tuesday, March 01 | 8:00AM - 11:00AM
Tumor Immunotherapy
Room: Peaks 4-5

Speaker 4 of 5
Ainhoa Perez-Diez, NIAID, National Institutes of Health, USA
Short Talk: CD4 Cells Can Be More Efficient at Tumor Rejection Than CD8 Cells

Tuesday, March 01 | 8:00AM - 11:00AM
Tumor Immunotherapy
Room: Peaks 4-5

Speaker 5 of 5
* Glenn Dranoff, Novartis Institutes for BioMedical Research, USA
Sequential Cancer Immunothherapy

Tuesday, March 01 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Tuesday, March 01 | 11:00AM - 1:00PM
Poster Setup
Room: Peaks 1-3


Tuesday, March 01 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-3


Tuesday, March 01 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Tuesday, March 01 | 5:00PM - 7:00PM
Inflammation Fibrosis and Malignant Pathogenesis
Room: Peaks 4-5

Speaker 1 of 4
* William G. Nelson, Johns Hopkins School of Medicine, USA
Inflammation and Prostate Carcinogenesis

Tuesday, March 01 | 5:00PM - 7:00PM
Inflammation Fibrosis and Malignant Pathogenesis
Room: Peaks 4-5

Speaker 2 of 4
Michael A. Hollingsworth, University of Nebraska Medical Center, USA
MUC1 and the Pathogenesis of Pancreatic Cancer

Tuesday, March 01 | 5:00PM - 7:00PM
Inflammation Fibrosis and Malignant Pathogenesis
Room: Peaks 4-5

Speaker 3 of 4
Anna Moore, Michigan State University, USA
Short Talk: UMUC-1 Tumor Antigen as an Imaging and Therapeutic Target

Tuesday, March 01 | 5:00PM - 7:00PM
Inflammation Fibrosis and Malignant Pathogenesis
Room: Peaks 4-5

Speaker 4 of 4
Dafna Bar-Sagi, New York University School of Medicine, USA
A Mouse Model of Hereditary Pancreatitis: Insights Into The Initiation of Pancreatic Cancer

Tuesday, March 01 | 7:00PM - 8:00PM
Social Hour
Room: Peaks 1-3


Tuesday, March 01 | 7:30PM - 10:00PM
Poster Session 2
Room: Peaks 1-3


Wednesday, March 02 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Wednesday, March 02 | 8:00AM - 11:15AM
Host Response to Pathogens and Soluble Mediators
Room: Peaks 4-5

Speaker 1 of 6
* Martin J. Blaser, New York University School of Medicine, USA
Helicobacter pylori diversity and interaction with gastric epithelial cells.

Wednesday, March 02 | 8:00AM - 11:15AM
Host Response to Pathogens and Soluble Mediators
Room: Peaks 4-5

Speaker 2 of 6
Bernhard Homey, Heinrich-Heine University Dussseldorf, Germany
Chemokine Receptors in Tumor Progression and Metastasis

Wednesday, March 02 | 8:00AM - 11:15AM
Host Response to Pathogens and Soluble Mediators
Room: Peaks 4-5

Speaker 3 of 6
Douglas McClain Noonan, Università degli Studi dell'Insubria, Italy
Short Talk: Inflammation Associated Angiogenesis: A New Potential Target for Tumor Therapy

Wednesday, March 02 | 8:00AM - 11:15AM
Host Response to Pathogens and Soluble Mediators
Room: Peaks 4-5

Speaker 4 of 6
M. Celeste Simon, University of Pennsylvania, USA
Hypoxia, Angiogenesis, and Tumor Progression

Wednesday, March 02 | 8:00AM - 11:15AM
Host Response to Pathogens and Soluble Mediators
Room: Peaks 4-5

Speaker 5 of 6
Joseph S. Palumbo, Cincinnati Children's Hospital Medical Center, USA
Short Talk: Mechanisms Linking Innate Hemostatic Factors and Innate Immunity to Metastatic Potential

Wednesday, March 02 | 8:00AM - 11:15AM
Host Response to Pathogens and Soluble Mediators
Room: Peaks 4-5

Speaker 6 of 6
Thomas Doetschman, University of Cincinnati, USA
TGFbeta, Inflammation and Colon Cancer Progression

Wednesday, March 02 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, March 02 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Wednesday, March 02 | 5:00PM - 7:00PM
Molecular Mechanisms for Cancer Prevention
Room: Peaks 4-5

Speaker 1 of 4
Michael Karin, University of California, San Diego, USA
The IKK Complex: Providing a Link Between Inflammation and Cancer

Wednesday, March 02 | 5:00PM - 7:00PM
Molecular Mechanisms for Cancer Prevention
Room: Peaks 4-5

Speaker 2 of 4
Ilan Stein, Hebrew University of Jerusalem, Israel
Short Talk: NF-kappaB Functions as a Tumor Promoter in Inflammation-Associated Cancer

Wednesday, March 02 | 5:00PM - 7:00PM
Molecular Mechanisms for Cancer Prevention
Room: Peaks 4-5

Speaker 3 of 4
George C. Prendergast, Lankenau Institute for Medical Research, USA
Short Talk: IDO in Immune Suppression, Cancer, and Cancer Therapy

Wednesday, March 02 | 5:00PM - 7:00PM
Molecular Mechanisms for Cancer Prevention
Room: Peaks 4-5

Speaker 4 of 4
* Raymond N. DuBois, Arizona State University, USA
COX-2, Inflammatory Mediators and Cancer Prevention

Wednesday, March 02 | 7:00PM - 8:00PM
Social Hour
Room: Copper top


Wednesday, March 02 | 8:00PM - 11:00PM
Entertainment
Room: Copper top


Wednesday, March 02 | 8:00PM - 11:00PM
Cash Bar
Room: Copper top


Thursday, March 03 | 10:26AM - 10:26AM
Departure


*Session Chair.