Web Desc
Leukocyte Trafficking: Cellular and Molecular Mechanisms
Organizer(s): Eugene C. Butcher and Ulrich H. von Andrian
Date: March 01 - 06, 2005
Location: Sagebrush Inn & Suites, Taos, NM, USA
Sponsored by ICOS Corporation and The Director's Fund
Summary of Meeting:
The past several years have seen considerable progress in our understanding of inflammation-, tissue-, and microenvironment-selective leukocyte trafficking and its role in immune responses and inflammation. Many adhesion and chemoattractant receptors and ligands that regulate leukocyte migration have been defined, as well as lipid-based traffic modulators and enzymes and signaling molecules involved. Their combinatorial use establishes trafficking programs that correlate with and help define the functional specialization of leukocyte subsets. Recent studies have demonstrated how tissue-specific antigen-presentation in secondary lymphoid organs induces B and T cells to acquire specialized adhesion and chemoattractant receptors, and how these pathways subsequently target antigen-experienced lymphocytes and their effector cell progeny in vivo. New imaging techniques provide unprecedented glimpses of these migratory dynamics in situ. Clinical trials are testing the efficacy of pharmacologic modulation of leukocyte traffic in autoimmune diseases. This program will bring together experts in the physiology and molecular biology of leukocyte trafficking to discuss the latest developments in the field, and to develop strategies for applying these insights to understanding and manipulating immune responses in vivo.
Discounted Abstract Deadline: November 1 2004
Discounted Registration Deadline: January 3 2005
We gratefully acknowledge additional support for this conference from:
Educational grant from Millennium Pharmaceuticals, Inc., The Takeda Oncology CompanyEMD Serono, Inc.ICOS CorporationNovartis Institutes for BioMedical Research
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Novartis Institutes for BioMedical Research
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13-AI063841-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, March 01 | 3:00PM - 7:30PM
Registration
Room: Chamisa Lobby


Tuesday, March 01 | 6:30PM - 7:30PM
Refreshments
Room: Chamisa Lobby


Tuesday, March 01 | 7:30PM - 8:30PM
Keynote Address
Room: Chamisa Ballroom 1

Speaker 1 of 1
Steven D. Rosen, University of California, San Francisco, USA

Wednesday, March 02 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Wednesday, March 02 | 8:00AM - 11:15AM
Lymphocyte Migration and Cell-Cell Interactions within Tissu
es

Room: Chamisa Ballroom 1

Speaker 1 of 8
* Eugene C. Butcher, Stanford University, USA

Wednesday, March 02 | 8:00AM - 11:15AM
Lymphocyte Migration and Cell-Cell Interactions within Tissu
es

Room: Chamisa Ballroom 1

Speaker 2 of 8
* Ulrich H. Von Andrian, Harvard Medical School, USA

Wednesday, March 02 | 8:00AM - 11:15AM
Lymphocyte Migration and Cell-Cell Interactions within Tissu
es

Room: Chamisa Ballroom 1

Speaker 3 of 8
Jason G. Cyster, HHMI/University of California, San Francisco, USA
Chemokines, S1P and Cell Migration in Lymphoid Tissues

Wednesday, March 02 | 8:00AM - 11:15AM
Lymphocyte Migration and Cell-Cell Interactions within Tissu
es

Room: Chamisa Ballroom 1

Speaker 4 of 8
Reina E. Mebius, Amsterdam UMC-VUmc, Netherlands
Cellular Interactions in Secondary and Tertiary Lymphoid Structure Formation

Wednesday, March 02 | 8:00AM - 11:15AM
Lymphocyte Migration and Cell-Cell Interactions within Tissu
es

Room: Chamisa Ballroom 1

Speaker 5 of 8
Gudrun F. Debes, Thomas Jefferson University, USA
Short Talk: CCR7 is Required for T Cell Exit from Peripheral Tissues

Wednesday, March 02 | 8:00AM - 11:15AM
Lymphocyte Migration and Cell-Cell Interactions within Tissu
es

Room: Chamisa Ballroom 1

Speaker 6 of 8
Michael L. Dustin, University of Oxford, UK
Intravital imaging of immunity in mice: patrolling networks

Wednesday, March 02 | 8:00AM - 11:15AM
Lymphocyte Migration and Cell-Cell Interactions within Tissu
es

Room: Chamisa Ballroom 1

Speaker 7 of 8
Thorsten R. Mempel, Massachusetts General Hospital, USA
Intravital Immunology: T cell Activation and Effector Function In Vivo

Wednesday, March 02 | 8:00AM - 11:15AM
Lymphocyte Migration and Cell-Cell Interactions within Tissu
es

Room: Chamisa Ballroom 1

Speaker 8 of 8
Marko Salmi, University of Turku, Finland
Short Talk: Adhesion Molecule CLEVER-1 Regulates Leukocyte Traffic both in the Vascular and Lymphatic Vessels

Wednesday, March 02 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Wednesday, March 02 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Wednesday, March 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Wednesday, March 02 | 2:30PM - 4:30PM
Workshop 1: In situ Visualization of Lymphocyte Migration an
d Activation
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Christopher H. Contag, Institute for Quantitative Health Sciences and Engineering, USA
Whole Body Imaging of Lymphocyte Trafficking

Wednesday, March 02 | 2:30PM - 4:30PM
Workshop 1: In situ Visualization of Lymphocyte Migration an
d Activation
Room: Chamisa Ballroom 1

Speaker 2 of 5
Michael D. Cahalan, University of California, Irvine, USA
Imaging T Cell Interactions with Dendritic Cells and B Cells in Lymph Node

Wednesday, March 02 | 2:30PM - 4:30PM
Workshop 1: In situ Visualization of Lymphocyte Migration an
d Activation
Room: Chamisa Ballroom 1

Speaker 3 of 5
* Ronald N. Germain, NIAID, National Institutes of Health, USA
Visualizing Dendritic Cell - Lymphocyte Interactions In Vivo

Wednesday, March 02 | 2:30PM - 4:30PM
Workshop 1: In situ Visualization of Lymphocyte Migration an
d Activation
Room: Chamisa Ballroom 1

Speaker 4 of 5
James T. Rosenbaum, Oregon Health & Science University, USA
Using the Eye to Image the Immune Response

Wednesday, March 02 | 2:30PM - 4:30PM
Workshop 1: In situ Visualization of Lymphocyte Migration an
d Activation
Room: Chamisa Ballroom 1

Speaker 5 of 5
Richard S. Lewis, Stanford University School of Medicine, USA
Calcium Oscillations Control Thymocyte Motility during Positive Selection in the Three-Dimensional Thymic Environment

Wednesday, March 02 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Chamisa Lobby


Wednesday, March 02 | 5:00PM - 7:00PM
Different Perspectives on Cell Migration
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Reina E. Mebius, Amsterdam UMC-VUmc, Netherlands

Wednesday, March 02 | 5:00PM - 7:00PM
Different Perspectives on Cell Migration
Room: Chamisa Ballroom 1

Speaker 2 of 5
Philippe Herbomel, Institut Pasteur, France
Macrophage Migration in Zebrafish Embryos

Wednesday, March 02 | 5:00PM - 7:00PM
Different Perspectives on Cell Migration
Room: Chamisa Ballroom 1

Speaker 3 of 5
Peter Friedl, NCMLS, Radboud University Nijmegen Medical Centre, Netherlands
Dynamic Mechanisms of Immune-Cell Interactions and Tumor Invasion

Wednesday, March 02 | 5:00PM - 7:00PM
Different Perspectives on Cell Migration
Room: Chamisa Ballroom 1

Speaker 4 of 5
* John (Jack) B. Hay, University of Toronto, Canada
Insights from Large Animal Studies of Lymphocyte Recirculation

Wednesday, March 02 | 5:00PM - 7:00PM
Different Perspectives on Cell Migration
Room: Chamisa Ballroom 1

Speaker 5 of 5
Adam Lacy-Hulbert, Benaroya Research Institute, USA
Short Talk: Roles for alpha (v) Integrins in Marginal Zone and B1 B Cell Trafficking and Activation Revealed by Conditional Gene Deletion

Wednesday, March 02 | 7:00PM - 8:00PM
Social Hour
Room: Chamisa Ballroom 2


Wednesday, March 02 | 7:30PM - 10:00PM
Poster Session 1
Room: Chamisa Ballroom 2


Thursday, March 03 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Thursday, March 03 | 8:00AM - 11:15AM
Chemokines and Novel Attractants in Leukocyte Trafficking
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Jason G. Cyster, HHMI/University of California, San Francisco, USA

Thursday, March 03 | 8:00AM - 11:15AM
Chemokines and Novel Attractants in Leukocyte Trafficking
Room: Chamisa Ballroom 1

Speaker 2 of 6
Bernhard Moser, Cardiff University School of Medicine, UK
Gamma Delta T Cell Trafficking

Thursday, March 03 | 8:00AM - 11:15AM
Chemokines and Novel Attractants in Leukocyte Trafficking
Room: Chamisa Ballroom 1

Speaker 3 of 6
* Osamu Yoshie, Kinki University, Japan
Antimicrobial and Related Activities of Chemokines

Thursday, March 03 | 8:00AM - 11:15AM
Chemokines and Novel Attractants in Leukocyte Trafficking
Room: Chamisa Ballroom 1

Speaker 4 of 6
Gerry J. Graham, University of Glasgow, UK
Regulation of the inflammatory response by the chemokine receptor D6

Thursday, March 03 | 8:00AM - 11:15AM
Chemokines and Novel Attractants in Leukocyte Trafficking
Room: Chamisa Ballroom 1

Speaker 5 of 6
Brian A. Zabel, Stanford University, USA
CMKLR1, Chemerin, and Plasmacytoid Dendritic Cell Recruitment to Sites of Tissue Damage: Linking Hemostasis, Inflammation, and Immunity

Thursday, March 03 | 8:00AM - 11:15AM
Chemokines and Novel Attractants in Leukocyte Trafficking
Room: Chamisa Ballroom 1

Speaker 6 of 6
Wolfgang Weninger, Centenary Institute, Australia
A Novel Mouse Model to Study Trafficking of Plasmacytoid Dendritic Cells in vivo

Thursday, March 03 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Thursday, March 03 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Thursday, March 03 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Thursday, March 03 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Chamisa Lobby


Thursday, March 03 | 5:00PM - 7:00PM
Adhesion Molecules and Signaling in Leukocyte Arrest and Mig
ration

Room: Chamisa Ballroom 1

Speaker 1 of 5
* Michael L. Dustin, University of Oxford, UK

Thursday, March 03 | 5:00PM - 7:00PM
Adhesion Molecules and Signaling in Leukocyte Arrest and Mig
ration

Room: Chamisa Ballroom 1

Speaker 2 of 5
Christopher V. Carman, Harvard Medical School, USA
Molecular and Cellular Regulation of Leukocyte Diapedesis

Thursday, March 03 | 5:00PM - 7:00PM
Adhesion Molecules and Signaling in Leukocyte Arrest and Mig
ration

Room: Chamisa Ballroom 1

Speaker 3 of 5
Carlo Laudanna, Italy
Chemokine Signaling to Integrin Activation: Requirements for Lymphocyte/HEV Interactions in vivo

Thursday, March 03 | 5:00PM - 7:00PM
Adhesion Molecules and Signaling in Leukocyte Arrest and Mig
ration

Room: Chamisa Ballroom 1

Speaker 4 of 5
Ronen Alon, Weizmann Institute of Science, Israel
Short Talk: Rolling Lymphocytes Abruptly Arrest on Endothelial ICAM-1 through a Subsecond Bi-Directional LFA-1 Activation by Surface-Bound Chemokine and Juxtaposed Ligand

Thursday, March 03 | 5:00PM - 7:00PM
Adhesion Molecules and Signaling in Leukocyte Arrest and Mig
ration

Room: Chamisa Ballroom 1

Speaker 5 of 5
Alexandre Chigaev, University of New Mexico Health, USA
Short Talk: Real-Time Regulation of VLA-4 Affinity and Conformation under Shear: A Mechanism for Capture of Leukocytes by Endothelium

Thursday, March 03 | 7:00PM - 8:00PM
Social Hour
Room: Chamisa Ballroom 2


Thursday, March 03 | 7:30PM - 10:00PM
Poster Session 2
Room: Chamisa Ballroom 2


Friday, March 04 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Friday, March 04 | 8:00AM - 11:00AM
In vivo Insights into Effector and Memory Cell Trafficking
Room: Chamisa Ballroom 1

Speaker 1 of 5
Alf Hamann, Charité University Medicine Berlin, Germany
Migration of Regulatory T cells

Friday, March 04 | 8:00AM - 11:00AM
In vivo Insights into Effector and Memory Cell Trafficking
Room: Chamisa Ballroom 1

Speaker 2 of 5
* Sirpa T. Jalkanen, University of Turku, Finland
Entrance and Exit Mechanisms in Leukocyte Trafficking: Role of VAP-1 and CLEVER-1

Friday, March 04 | 8:00AM - 11:00AM
In vivo Insights into Effector and Memory Cell Trafficking
Room: Chamisa Ballroom 1

Speaker 3 of 5
* Charles R. Mackay, Monash University, Australia
Gene Microarrays Reveal Migration Mechanisms for Different Types of Immune Responses

Friday, March 04 | 8:00AM - 11:00AM
In vivo Insights into Effector and Memory Cell Trafficking
Room: Chamisa Ballroom 1

Speaker 4 of 5
Chang Hwan Kim, Purdue University, USA
Short Talk: Regulatory T Cells Programmed to Home to Follicles Suppress T Helper Activity and Humoral Immune Responses

Friday, March 04 | 8:00AM - 11:00AM
In vivo Insights into Effector and Memory Cell Trafficking
Room: Chamisa Ballroom 1

Speaker 5 of 5
Jorge Rodrigo Mora, Takeda Pharmaceuticals, USA
Short Talk: Reciprocal and Dynamic Control of T Cell Homing by Gut and Peripheral Dendritic Cells

Friday, March 04 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Friday, March 04 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Friday, March 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Friday, March 04 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Chamisa Lobby


Friday, March 04 | 5:00PM - 7:00PM
Dendritic Cells and Trafficking
Room: Chamisa Ballroom 1

Speaker 1 of 4
* Federica Sallusto, Università della Svizzera Italiana & ETH Zurich, Switzerland
Regulation of dendritic cell and lymphocyte migration to lymph nodes

Friday, March 04 | 5:00PM - 7:00PM
Dendritic Cells and Trafficking
Room: Chamisa Ballroom 1

Speaker 2 of 4
* Michael D. Gunn, Duke University Medical Center, USA
Antigen Presenting Cell Types Recruited to the Lung by MCP-1

Friday, March 04 | 5:00PM - 7:00PM
Dendritic Cells and Trafficking
Room: Chamisa Ballroom 1

Speaker 3 of 4
Gwendalyn J. Randolph, Washington University, USA
Dendritic cell migration from the periphery to lymph nodes

Friday, March 04 | 5:00PM - 7:00PM
Dendritic Cells and Trafficking
Room: Chamisa Ballroom 1

Speaker 4 of 4
Raymond A. Daynes, University of Utah School of Medicine, USA
Short Talk: Vaccine Adjuvants that Promote the Migration of Antigen Presenting Dendritic Cells from the Skin to Peyer’s Patches are Capable of Inducing both Systemic and Mucosal Immune Responses

Friday, March 04 | 7:00PM - 8:00PM
Social Hour
Room: Chamisa Ballroom 2


Friday, March 04 | 7:30PM - 10:00PM
Poster Session 3
Room: Chamisa Ballroom 2


Saturday, March 05 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Saturday, March 05 | 8:00AM - 11:15AM
Leukocyte Trafficking in Inflammation and Disease
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Steven D. Rosen, University of California, San Francisco, USA

Saturday, March 05 | 8:00AM - 11:15AM
Leukocyte Trafficking in Inflammation and Disease
Room: Chamisa Ballroom 1

Speaker 2 of 7
Klaus Ley, La Jolla Institute for Allergy and Immunology, USA
Chemokine- and E-Selectin-Dependent Neutrophil and Monocyte Arrest Under Flow


Saturday, March 05 | 8:00AM - 11:15AM
Leukocyte Trafficking in Inflammation and Disease
Room: Chamisa Ballroom 1

Speaker 3 of 7
Antal Rot, University of York, UK
To Serve or Protect: The Biology of Chemokine Interceptors

Saturday, March 05 | 8:00AM - 11:15AM
Leukocyte Trafficking in Inflammation and Disease
Room: Chamisa Ballroom 1

Speaker 4 of 7
* Sara Michie, Stanford University, USA
Short Talk: Lymphocyte Migration to Bronchus Associated Lymphoid Tissue

Saturday, March 05 | 8:00AM - 11:15AM
Leukocyte Trafficking in Inflammation and Disease
Room: Chamisa Ballroom 1

Speaker 5 of 7
John B. Lowe, Genentech, Inc., USA
Glycan-Dependent Control of Leukocyte Biology

Saturday, March 05 | 8:00AM - 11:15AM
Leukocyte Trafficking in Inflammation and Disease
Room: Chamisa Ballroom 1

Speaker 6 of 7
Minoru Fukuda, Sanford-Burnham Medical Research Institute, USA
Roles of Glycosyltransferases and Sulfotransferases in the Synthesis of L-Selectin Ligands

Saturday, March 05 | 8:00AM - 11:15AM
Leukocyte Trafficking in Inflammation and Disease
Room: Chamisa Ballroom 1

Speaker 7 of 7
P. Sriramarao, La Jolla Institute for Molecular Medicine, USA
Short Talk: Serotonin is a Potent Chemoattractant for Eosinophils and Functions Additively with Eotaxin

Saturday, March 05 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Saturday, March 05 | 2:30PM - 4:30PM
Workshop 2: Preclinical and Clinical Anti-Adhesion Therapy f
or Autoimmune Diseases
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Britta Engelhardt, Theodor Kocher Institute/Universitat Bern, Switzerland
T Cell Traffic into the CNS

Saturday, March 05 | 2:30PM - 4:30PM
Workshop 2: Preclinical and Clinical Anti-Adhesion Therapy f
or Autoimmune Diseases
Room: Chamisa Ballroom 1

Speaker 2 of 6
Michael Briskin, Trammel Therapeutics, USA
Integrins as Therapeutic Targets for Inflammatory Bowel Disease

Saturday, March 05 | 2:30PM - 4:30PM
Workshop 2: Preclinical and Clinical Anti-Adhesion Therapy f
or Autoimmune Diseases
Room: Chamisa Ballroom 1

Speaker 3 of 6
Jesús Rivera-Nieves, Inflammatory Bowel Disease Center, USA
Short Talk: P-Selectin Glycoprotein Ligand-1 (PSGL-1) is Expressed on Intestinal Microvascular Endothelium and its Blockade Attenuates Chronic Ileitis in SAMP1/YitFc Mice

Saturday, March 05 | 2:30PM - 4:30PM
Workshop 2: Preclinical and Clinical Anti-Adhesion Therapy f
or Autoimmune Diseases
Room: Chamisa Ballroom 1

Speaker 4 of 6
Antje Margret Wengner, Imperial College London, UK
Short Talk: Critical Role of the Chemokine Receptors CXCR5 and CCR7 in the Initiation and Progression of Antigen-Induced Arthritis (AIA)

Saturday, March 05 | 2:30PM - 4:30PM
Workshop 2: Preclinical and Clinical Anti-Adhesion Therapy f
or Autoimmune Diseases
Room: Chamisa Ballroom 1

Speaker 5 of 6
Robert Weissert, Merck Serono Intl. SA, Geneva Research Center, Switzerland
Short Talk: Targeting Cellular Trafficking in Experimental Autoimmune Encephalomyelitis

Saturday, March 05 | 2:30PM - 4:30PM
Workshop 2: Preclinical and Clinical Anti-Adhesion Therapy f
or Autoimmune Diseases
Room: Chamisa Ballroom 1

Speaker 6 of 6
Katalin Mikecz, Rush University Medical Center, USA
Short Talk: Intravital Microscopy of Joints

Saturday, March 05 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Chamisa Lobby


Saturday, March 05 | 5:00PM - 7:00PM
Lipid Modulators of Leukocyte Traffic
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Gwendalyn J. Randolph, Washington University, USA

Saturday, March 05 | 5:00PM - 7:00PM
Lipid Modulators of Leukocyte Traffic
Room: Chamisa Ballroom 1

Speaker 2 of 5
Andrew D. Luster, Massachusetts General Hospital, USA
Leukotienes and Leukocyte Trafficking

Saturday, March 05 | 5:00PM - 7:00PM
Lipid Modulators of Leukocyte Traffic
Room: Chamisa Ballroom 1

Speaker 3 of 5
Makoto Iwata, Tokushima Bunri University, Japan
Retinoic Acid Imprints Gut-Homing Specificity on T Cells

Saturday, March 05 | 5:00PM - 7:00PM
Lipid Modulators of Leukocyte Traffic
Room: Chamisa Ballroom 1

Speaker 4 of 5
* Hugh Rosen, ActivX Biosciences, USA
Curious Evolution: S1P and the control of lymphocyte recirculation

Saturday, March 05 | 5:00PM - 7:00PM
Lipid Modulators of Leukocyte Traffic
Room: Chamisa Ballroom 1

Speaker 5 of 5
Markus H. Gräler, Hannover Medical School, Germany
Short Talk: Influence of Sphingosine 1-Phosphate and Its Receptor S1P1 on Lymphocyte Migration and Immunity

Saturday, March 05 | 7:00PM - 8:00PM
Social Hour
Room: Chamisa Ballroom 2


Saturday, March 05 | 8:00PM - 11:00PM
Entertainment
Room: Chamisa Ballroom 2


Saturday, March 05 | 8:00PM - 11:00PM
Cash Bar
Room: Chamisa Ballroom 2


Sunday, March 06 | 10:26AM - 10:26AM
Departure


*Session Chair.