Web Desc
Genome Instability and Repair
Organizer(s): Vihelm A. Bohr, Nancy Maizels and Erling C. Seeberg
Date: March 15 - 20, 2005
Location: Sagebrush Inn & Suites, Taos, NM, USA
Supported by The Director's Fund
Summary of Meeting:
Genomic stability is essential for normal cellular function, and highly conserved pathways have evolved to repair DNA damage and prevent genomic instability. This meeting will focus on recent advances in understanding the nature and causes of genomic instability, the mechanisms of normal DNA repair, and the consequences of failure in DNA repair. Dramatic increases in the level of genomic instability can occur during normal cell development and aging, and genomic instability is also associated with genetic disease and cancer. Emphasis will be placed on advances that provide mechanistic understanding of specific repair pathways that maintain genomic integrity to prevent disease. The goal of this meeting is to bring together leaders in these areas of research, and via presentations, workshops and discussions to identify new areas of investigation and possible therapeutic strategies that will contribute to the maintenance of genomic integrity. The Passing of Erling Seeberg Erling Seeberg passed away last December at the age of 58 years. He was an outstanding scientist, a terrific colleague and a good friend. He was a co organizer of this conference. He will be sorely missed for his knowledge, insight and wits. I (VB) have collaborated with Erling over years and worked with him on many projects and in the organization of various arrangements. He had a clear and strong sense of quality and was a great asset to an organizing committee like the one for this meeting. His input on this meeting is greatly appreciated and has been an important help for us. We will miss Erling's presence at the meeting and his knowledge and incisive questions. And we will miss his presence at the social events, because he enjoyed a good time with friends, and we will miss the after dinner speech with a funny story or two that he would most certainly have delivered at this event. Let us take the opportunity to remember him throughout this meeting and think not only about all his very important scientific contributions, but also about the wonderful person that he was. ~ Vilhelm A. Bohr and Nancy Maizels
Discounted Abstract Deadline: November 15 2004
Discounted Registration Deadline: January 18 2005
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Pfizer Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute on Aging (NIA)
Grant No. 1R13-AG025621-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, March 15 | 3:00PM - 7:30PM
Registration
Room: Chamisa Lobby


Tuesday, March 15 | 6:30PM - 7:30PM
Refreshments
Room: Chamisa Lobby


Tuesday, March 15 | 7:30PM - 7:45PM
Opening Address and Tribute to Erling Seeberg
Room: Chamisa Ballroom 1

Speaker 2 of 2
Nancy Maizels, University of Washington School of Medicine, USA

Tuesday, March 15 | 7:30PM - 7:45PM
Opening Address and Tribute to Erling Seeberg
Room: Chamisa Ballroom 1

Speaker 1 of 2
Vilhelm A. Bohr, NIA, National Institutes of Health, USA

Tuesday, March 15 | 7:45PM - 9:30PM
Keynote Session
Room: Chamisa Ballroom 1

Speaker 2 of 2
Jerry W. Shay, University of Texas Southwestern Medical Center, USA
Telomeres and Telomerase in Response to DNA Damage Signaling

Tuesday, March 15 | 7:45PM - 9:30PM
Keynote Session
Room: Chamisa Ballroom 1

Speaker 1 of 2
Jan H. J. Hoeijmakers, Erasmus MC, Netherlands
DNA Repair in Cancer and Aging

Wednesday, March 16 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Wednesday, March 16 | 8:00AM - 11:15AM
Recognition of DNA Damage
Room: Chamisa Ballroom 1

Speaker 6 of 6
John M. Essigmann, Massachusetts Institute of Technology, USA
Sources and Fates of DNA Damage

Wednesday, March 16 | 8:00AM - 11:15AM
Recognition of DNA Damage
Room: Chamisa Ballroom 1

Speaker 5 of 6
Arne Klungland, National Hospital, University of Oslo, Norway
Short Talk: Knockout, Knockin and Knockdown of FEN1

Wednesday, March 16 | 8:00AM - 11:15AM
Recognition of DNA Damage
Room: Chamisa Ballroom 1

Speaker 4 of 6
Lars Eide, National Hospital of Norway, Norway
Short Talk: The Sensitivity of Cockayne Syndrome B Cells to Oxidative Stress is Promoted by the Action of the Ogg1 Mitochondrial 8-Oxoguanine DNA Glycosylase

Wednesday, March 16 | 8:00AM - 11:15AM
Recognition of DNA Damage
Room: Chamisa Ballroom 1

Speaker 3 of 6
Keith W. Caldecott, University of Sussex, UK
Chromosomal Single-Strand Break Repair and Neurodegenerative Disease

Wednesday, March 16 | 8:00AM - 11:15AM
Recognition of DNA Damage
Room: Chamisa Ballroom 1

Speaker 2 of 6
Sankar Mitra, University of Texas Medical Branch, Galveston, USA
Newly Discovered Human DNA Glycosylases (NEILs) are Functionally Distinct from the Previously Characterized OGG1/NTH1

Wednesday, March 16 | 8:00AM - 11:15AM
Recognition of DNA Damage
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Hans E. Krokan, Norwegian University of Science and Technology, Norway
Uracil in DNA - Consequences and Mechanisms of Repair

Wednesday, March 16 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Wednesday, March 16 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Wednesday, March 16 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Wednesday, March 16 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Chamisa Lobby


Wednesday, March 16 | 5:00PM - 7:00PM
Responses to DNA Damage
Room: Chamisa Ballroom 1

Speaker 4 of 4
Fumio Hanaoka, Osaka University, Japan
Molecular Mechanisms of Translesion DNA Synthesis by XPV Polymerase

Wednesday, March 16 | 5:00PM - 7:00PM
Responses to DNA Damage
Room: Chamisa Ballroom 1

Speaker 3 of 4
Kenna L. Anderes, Cylene Pharmaceuticals, USA
Therapeutic Implications of DNA Repair and Checkpoint Inhibition

Wednesday, March 16 | 5:00PM - 7:00PM
Responses to DNA Damage
Room: Chamisa Ballroom 1

Speaker 2 of 4
Eric T. Larson, University of Washington, USA
Short Talk: Abasic Endonuclease Activity of MRE11/RAD50

Wednesday, March 16 | 5:00PM - 7:00PM
Responses to DNA Damage
Room: Chamisa Ballroom 1

Speaker 1 of 4
* Leona D. Samson, Massachusetts Institute of Technology, USA
Global Responses to DNA Damaging Agents

Wednesday, March 16 | 7:00PM - 8:00PM
Social Hour
Room: Chamisa Ballroom 2


Wednesday, March 16 | 7:30PM - 10:00PM
Poster Session 1
Room: Chamisa Ballroom 2


Thursday, March 17 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Thursday, March 17 | 8:00AM - 11:15AM
Mechanisms of DNA Repair, Base Modifications
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Samuel H. Wilson, NIEHS, National Institutes of Health, USA
Structural Biology of Repair Polymerases

Thursday, March 17 | 8:00AM - 11:15AM
Mechanisms of DNA Repair, Base Modifications
Room: Chamisa Ballroom 1

Speaker 2 of 6
Bruce Demple, Stony Brook University Medical School, USA
Roles of Mammalian BER in Handling Endogenous and Environmental DNA
damage


Thursday, March 17 | 8:00AM - 11:15AM
Mechanisms of DNA Repair, Base Modifications
Room: Chamisa Ballroom 1

Speaker 3 of 6
Bernd Kaina, University of Mainz, Germany
Short Talk: Apoptotic Signaling Triggered by O6-Alkylguanine Lesions

Thursday, March 17 | 8:00AM - 11:15AM
Mechanisms of DNA Repair, Base Modifications
Room: Chamisa Ballroom 1

Speaker 4 of 6
Grigory L. Dianov, Medical Research Council, UK
Short Talk: Protein Dynamics on Damaged DNA during Base Excision
Repair in Human Cell Extracts


Thursday, March 17 | 8:00AM - 11:15AM
Mechanisms of DNA Repair, Base Modifications
Room: Chamisa Ballroom 1

Speaker 5 of 6
Akira Yasui, Institute of Development, Aging and Cancer, Tohoku University, Japan
Dynamic Responses to Single-Strand Breaks in Human Cells

Thursday, March 17 | 8:00AM - 11:15AM
Mechanisms of DNA Repair, Base Modifications
Room: Chamisa Ballroom 1

Speaker 6 of 6
John A. Tainer, The Scripps Research Institute, USA
DNA Repair Choreography: Conformational Controls for Chemistry and Coordination

Thursday, March 17 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Thursday, March 17 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Chamisa Lobby


Thursday, March 17 | 5:00PM - 7:00PM
Mechanisms of Processing Repair Intermediates
Room: Chamisa Ballroom 1

Speaker 1 of 4
* Penny A. Jeggo, University of Sussex, UK
A Novel Role for ATM in DNA Double Strand Break Rejoining

Thursday, March 17 | 5:00PM - 7:00PM
Mechanisms of Processing Repair Intermediates
Room: Chamisa Ballroom 1

Speaker 2 of 4
Laura J. Niedernhofer, The Scripps Research Institute, USA
Premature Aging in Crosslink Repair-Deficient Ercc1-/- Mice

Thursday, March 17 | 5:00PM - 7:00PM
Mechanisms of Processing Repair Intermediates
Room: Chamisa Ballroom 1

Speaker 3 of 4
Anna Marie Skalka, Fox Chase Cancer Center, USA
Short Talk: Histone H2AX is Phosphorylated at Sites of Retroviral DNA Integration, but is Dispensable for Post-Integration Repair

Thursday, March 17 | 5:00PM - 7:00PM
Mechanisms of Processing Repair Intermediates
Room: Chamisa Ballroom 1

Speaker 4 of 4
Stephen C. West, Francis Crick Institute, UK
Double-Strand Break Repair by Homologous Recombination

Thursday, March 17 | 7:00PM - 8:00PM
Social Hour
Room: Chamisa Ballroom 2


Thursday, March 17 | 8:00PM - 10:00PM
Workshop 1: Genomic Instability in Cancer and Aging
Room: Chamisa Ballroom 1

Speaker 1 of 11
* Lawrence A. Loeb, University of Washington, USA
Introduction

Thursday, March 17 | 8:00PM - 10:00PM
Workshop 1: Genomic Instability in Cancer and Aging
Room: Chamisa Ballroom 1

Speaker 2 of 11
Robert D. Shereda, University of Wisconsin Medical School, USA
Protein-Protein Interactions Involving E. coli RecQ DNA Helicase

Thursday, March 17 | 8:00PM - 10:00PM
Workshop 1: Genomic Instability in Cancer and Aging
Room: Chamisa Ballroom 1

Speaker 3 of 11
Carla Grandori, SEngine Precision Medicine and Cure First, USA
Role of Werner Protein in Myc-Induced DNA Damage

Thursday, March 17 | 8:00PM - 10:00PM
Workshop 1: Genomic Instability in Cancer and Aging
Room: Chamisa Ballroom 1

Speaker 4 of 11
Nicholas D. Chester, Harvard Medical School, USA
Induction of a Global Secondary Genomic Instability in Bloom’s Syndrome Tumor Cell Lines is Preceded by Chromosome Loss


Thursday, March 17 | 8:00PM - 10:00PM
Workshop 1: Genomic Instability in Cancer and Aging
Room: Chamisa Ballroom 1

Speaker 5 of 11
Ashwini S. Kamath-Loeb, University of Washington, USA
The Enzymatic Activities of the Werner Syndrome Protein are Disabled by the Amino Acid Polymorphism, R834C

Thursday, March 17 | 8:00PM - 10:00PM
Workshop 1: Genomic Instability in Cancer and Aging
Room: Chamisa Ballroom 1

Speaker 6 of 11
Bernard S. Lopez, Institut Gustave Roussy, France
Genome Rearrangements Induced by Double Strand Breaks and NHEJ In Mammalian Cells

Thursday, March 17 | 8:00PM - 10:00PM
Workshop 1: Genomic Instability in Cancer and Aging
Room: Chamisa Ballroom 1

Speaker 7 of 11
Michelle L. Duquette, University of Washington, USA
Transcription of c-MYC Induces DNA Structure Formation in Translocation Breakpoint Associated Regions

Thursday, March 17 | 8:00PM - 10:00PM
Workshop 1: Genomic Instability in Cancer and Aging
Room: Chamisa Ballroom 1

Speaker 8 of 11
Heng-Kuan Wong, NIA, National Institutes of Health, USA
The XRCC1 and DNA Polymerase b Interaction Contributes to Cellular Alkylating-Agent Resistance and Single-Strand Break Repair

Thursday, March 17 | 8:00PM - 10:00PM
Workshop 1: Genomic Instability in Cancer and Aging
Room: Chamisa Ballroom 1

Speaker 9 of 11
Rhoderick H. Elder, Paterson Institute for Cancer Research, UK
Compensating for DNA Glycosylase Deficiency

Thursday, March 17 | 8:00PM - 10:00PM
Workshop 1: Genomic Instability in Cancer and Aging
Room: Chamisa Ballroom 1

Speaker 10 of 11
Sophie Bellon, Medical Research Council, UK
Effect of NAD+ in Base Excision Repair of Simple or Clustered DNA Damaged Sites

Thursday, March 17 | 8:00PM - 10:00PM
Workshop 1: Genomic Instability in Cancer and Aging
Room: Chamisa Ballroom 1

Speaker 11 of 11
Yousin Suh, Albert Einstein College of Medicine, USA
Apoptosis, Genome Maintenance, and Aging

Friday, March 18 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Friday, March 18 | 8:00AM - 11:00AM
Repair and Recombination in Development
Room: Chamisa Ballroom 1

Speaker 1 of 4
* Nancy Maizels, University of Washington School of Medicine, USA
Mutagenic Repair and Recombination in the Immune Response

Friday, March 18 | 8:00AM - 11:00AM
Repair and Recombination in Development
Room: Chamisa Ballroom 1

Speaker 2 of 4
Mark P. Mattson, National Institute on Aging, and Johns Hopkins University School of Medicine, USA
DNA Damage and Repair in the Nervous System

Friday, March 18 | 8:00AM - 11:00AM
Repair and Recombination in Development
Room: Chamisa Ballroom 1

Speaker 3 of 4
Susanna Maxwell Lewis, Harvard Medical School, USA
Short Talk: True Perfect Palindromes in the Human Genome: Validation and Analysis of Rearrangement Hyper-Hotspots

Friday, March 18 | 8:00AM - 11:00AM
Repair and Recombination in Development
Room: Chamisa Ballroom 1

Speaker 4 of 4
David B. Roth, New York University School of Medicine, USA
The Recombinase as Gatekeeper: Linking V(D)J Recombination to DNA Repair

Friday, March 18 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Friday, March 18 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Friday, March 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Friday, March 18 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Chamisa Lobby


Friday, March 18 | 5:00PM - 7:00PM
Aging
Room: Chamisa Ballroom 1

Speaker 1 of 4
* Vilhelm A. Bohr, NIA, National Institutes of Health, USA
Human Premature Aging Proteins: Links between Aging and DNA Repair

Friday, March 18 | 5:00PM - 7:00PM
Aging
Room: Chamisa Ballroom 1

Speaker 2 of 4
Judith Campisi, Buck Institute for Research on Aging, USA
Postponing Aging and Cancer: Cellular Functions of the BLM and WRN Helicases

Friday, March 18 | 5:00PM - 7:00PM
Aging
Room: Chamisa Ballroom 1

Speaker 3 of 4
Wen-Hsing Cheng, USA
Short Talk: WRN Functions in the Cellular Response to DNA Cross-Links

Friday, March 18 | 5:00PM - 7:00PM
Aging
Room: Chamisa Ballroom 1

Speaker 4 of 4
Jan Vijg, Albert Einstein College of Medicine, USA
Genome Instability and Aging

Friday, March 18 | 7:00PM - 8:00PM
Social Hour
Room: Chamisa Ballroom 2


Friday, March 18 | 7:30PM - 10:00PM
Poster Session 2
Room: Chamisa Ballroom 2


Saturday, March 19 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Saturday, March 19 | 8:00AM - 11:00AM
Chromosomal Outcomes of Genomic Instability
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Alan R. Lehman, University of Sussex, UK
The XPD Gene: Genotypes and Phenotypes

Saturday, March 19 | 8:00AM - 11:00AM
Chromosomal Outcomes of Genomic Instability
Room: Chamisa Ballroom 1

Speaker 2 of 5
Patricia L. Opresko, University of Pittsburgh, USA
RecQ Helicases and DNA Repair Pathways at Telomeric DNA

Saturday, March 19 | 8:00AM - 11:00AM
Chromosomal Outcomes of Genomic Instability
Room: Chamisa Ballroom 1

Speaker 3 of 5
Weihang Chai, Washington State University, USA
Short Talk: The Role of DNA Repair Factors in Telomere End Processing

Saturday, March 19 | 8:00AM - 11:00AM
Chromosomal Outcomes of Genomic Instability
Room: Chamisa Ballroom 1

Speaker 4 of 5
Thomas E. Wilson, University of Michigan, USA
Short Talk: Separation-of-Function Mutants of Ku80 and Xrs2; Evidence for a Concerted NHEJ Repairosome

Saturday, March 19 | 8:00AM - 11:00AM
Chromosomal Outcomes of Genomic Instability
Room: Chamisa Ballroom 1

Speaker 5 of 5
Peter M. Lansdorp, BC Cancer Research Center, Canada
Helicase-Like Proteins Required to Prevent Instability of G-Rich DNA in C. elegans and Mice

Saturday, March 19 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Saturday, March 19 | 3:00PM - 4:30PM
Workshop 2: Dynamics, Modulation and Regulation of DNA Repai
r
Room: Chamisa Ballroom 1

Speaker 1 of 8
* Michael M. Seidman, NIA, National Institutes of Health, USA
Introduction

Saturday, March 19 | 3:00PM - 4:30PM
Workshop 2: Dynamics, Modulation and Regulation of DNA Repai
r
Room: Chamisa Ballroom 1

Speaker 2 of 8
Michael J. Siciliano, University of Texas, USA
Microsatellite Instability (MSI) Increases in PBLs of Normals with Age and in Older Persons Approaches Levels Seen in the PBLs of Younger Patients Carrying Germline Mutations for Cancer Predisposition

Saturday, March 19 | 3:00PM - 4:30PM
Workshop 2: Dynamics, Modulation and Regulation of DNA Repai
r
Room: Chamisa Ballroom 1

Speaker 3 of 8
Yiduo Hu, Editas Medicine, USA
RecQ DNA Helicases Blm and Recql5 have Non-Redundant Functions in the Suppression of Mitotic Crossovers in Mouse

Saturday, March 19 | 3:00PM - 4:30PM
Workshop 2: Dynamics, Modulation and Regulation of DNA Repai
r
Room: Chamisa Ballroom 1

Speaker 4 of 8
Ramiro G. Dip, University of Zurich, Switzerland
Molecular Analysis of the Xeroderma pigmentosum Group A Protein Function by Site-Directed Mutagenesis

Saturday, March 19 | 3:00PM - 4:30PM
Workshop 2: Dynamics, Modulation and Regulation of DNA Repai
r
Room: Chamisa Ballroom 1

Speaker 5 of 8
Jinhu Yin, NIA, National Institutes of Health, USA
BLAP75, an Essential Component of Bloom Syndrome Protein Complexes and Required for Maintaining Genome Integrity

Saturday, March 19 | 3:00PM - 4:30PM
Workshop 2: Dynamics, Modulation and Regulation of DNA Repai
r
Room: Chamisa Ballroom 1

Speaker 6 of 8
Barbara C. Godthelp, Leiden University Medical Center, Netherlands
BRCA2, A True Member of the Fanconi anemia/BRCA DNA Repair Pathway?

Saturday, March 19 | 3:00PM - 4:30PM
Workshop 2: Dynamics, Modulation and Regulation of DNA Repai
r
Room: Chamisa Ballroom 1

Speaker 7 of 8
Patricia L. Foster, Indiana University, USA
Error-Prone DNA Polymerase IV (DinB) and the Stress-Responses of E. coli

Saturday, March 19 | 3:00PM - 4:30PM
Workshop 2: Dynamics, Modulation and Regulation of DNA Repai
r
Room: Chamisa Ballroom 1

Speaker 8 of 8
Barbara Kraatz Fortini, University of Southern California, USA
Dna2 Helicase/Nuclease is a Substrate of Mec1

Saturday, March 19 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Chamisa Lobby


Saturday, March 19 | 5:00PM - 7:00PM
Diseases of DNA Repair
Room: Chamisa Ballroom 1

Speaker 1 of 3
* Ian D. Hickson, University of Copenhagen, Denmark
Genomic Instability and Cancer: Defining the Role of the Bloom’s Syndrome Helicase

Saturday, March 19 | 5:00PM - 7:00PM
Diseases of DNA Repair
Room: Chamisa Ballroom 1

Speaker 2 of 3
Curtis C. Harris, NCI, National Institutes of Health, USA
p53 and Genomic Instability Diseases: At the Crossroads of DNA Repair and Recombination

Saturday, March 19 | 5:00PM - 7:00PM
Diseases of DNA Repair
Room: Chamisa Ballroom 1

Speaker 3 of 3
Tomas Lindahl, Cancer Research UK, UK
Recent Progress on Repair of Alkylated and Oxidized DNA Bases in Mammalian Cells

Saturday, March 19 | 7:00PM - 8:00PM
Social Hour
Room: Chamisa Ballroom 2


Saturday, March 19 | 8:00PM - 11:00PM
Entertainment
Room: Chamisa Ballroom 2


Saturday, March 19 | 8:00PM - 11:00PM
Cash Bar
Room: Chamisa Ballroom 2


Sunday, March 20 | 12:26AM - 12:26AM
Departure


*Session Chair.