Web Desc
Roles of TGF-ß in Disease Pathogenesis: Novel Therapeutic Strategies
Organizer(s): Anita B. Roberts, Michael B. Sporn and John M. McPherson
Date: March 28 - April 02, 2005
Location: Keystone Resort, Keystone, CO, USA
Supported by The Director's Fund
Summary of Meeting:
Elucidation of the signal transduction pathways of TGF-ß has heralded an exciting new era enabling insights into molecular mechanisms of this multifunctional molecule in both normal adult physiology and disease pathogenesis, including especially wound healing, fibrosis, carcinogenesis and immune cell dysfunction. Characterization of the receptor kinases and identification of the Smad signaling pathway has identified new molecular targets and led to development of novel inhibitors of the pathway. Increased understanding of the biochemistry of TGF-ß itself has also enabled development of anti-ligand approaches. Our goal for this conference is to bring together researchers focused on the basic biochemistry of TGF-ß and on the use of animal models to elucidate its roles in disease pathogenesis and researchers from Biotech/Pharma who are developing new drugs based on the TGF-ß pathway to both enhance our insights into mechanisms of action of TGF-ß and provide novel therapeutic approaches for clinical treatment of disease.
Discounted Abstract Deadline: November 29 2004
Discounted Registration Deadline: January 28 2005
We gratefully acknowledge additional support for this conference from:
Genzyme CorporationNovartis Institutes for BioMedical Research
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Antisense Pharma GmbH

Educational grant from Lilly USA, LLC

Genentech, Inc.

Genzyme Corporation

GlaxoSmithKline

Janssen Pharmaceuticals, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, March 28 | 3:00PM - 7:30PM
Registration
Room: Shavano Peak Foyer


Monday, March 28 | 6:30PM - 7:30PM
Refreshments
Room: Shavano Peak Foyer


Monday, March 28 | 7:30PM - 8:30PM
Keynote Address
Room: Red Cloud/Shavano

Speaker 1 of 1
Joan Massagué, Memorial Sloan Kettering Cancer Center, USA
The Logic of TGFbeta Signaling


Tuesday, March 29 | 7:00AM - 8:00AM
Breakfast
Room: Grays


Tuesday, March 29 | 8:00AM - 11:00AM
New Molecular Targets in TGF-ß Signaling
Room: Longs

Speaker 1 of 5
* Edward B. Leof, Mayo Clinic, USA
Smad-Independent TGFbeta Signaling: potential Targets for the Treatment of Fibrotic Disease

Tuesday, March 29 | 8:00AM - 11:00AM
New Molecular Targets in TGF-ß Signaling
Room: Longs

Speaker 2 of 5
Jeffrey L. Wrana, Mount Sinai Hospital, Canada
High THroughput Biology and TGFbeta Signaling

Tuesday, March 29 | 8:00AM - 11:00AM
New Molecular Targets in TGF-ß Signaling
Room: Longs

Speaker 3 of 5
Fang Liu, Rutgers University, USA
Inhibition of Smad Antiproliferative Function by CDK Phosphorylation

Tuesday, March 29 | 8:00AM - 11:00AM
New Molecular Targets in TGF-ß Signaling
Room: Longs

Speaker 4 of 5
Steven Dooley, Medical Faculty Mannheim, University of Heidelberg, Germany
Short Talk: Identification of Id1 as Critical Mediator in TGF-ß-Induced Transdifferentiation of Hepatic Stellate Cells

Tuesday, March 29 | 8:00AM - 11:00AM
New Molecular Targets in TGF-ß Signaling
Room: Longs

Speaker 5 of 5
Jeremy Naftali Rich, Cleveland Clinic, USA
Short Talk

Tuesday, March 29 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Foyer


Tuesday, March 29 | 11:00AM - 1:00PM
Poster Setup
Room: Grays


Tuesday, March 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Grays


Tuesday, March 29 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Foyer


Tuesday, March 29 | 5:00PM - 7:00PM
Role of TGF-ß in Inflammation/ Fibrosis I
Room: Longs

Speaker 1 of 5
* Michael B. Sporn, Dartmouth Medical School, USA

Tuesday, March 29 | 5:00PM - 7:00PM
Role of TGF-ß in Inflammation/ Fibrosis I
Room: Longs

Speaker 2 of 5
Anita B. Roberts, National Institutes of Health, USA
Smad3 as a Target in TGF-ß-Mediated Epithelial-to-Mesenchymal Transition, Fibrosis and Metastasis

Tuesday, March 29 | 5:00PM - 7:00PM
Role of TGF-ß in Inflammation/ Fibrosis I
Room: Longs

Speaker 3 of 5
Christoph Becker, Friedrich Alexander University of Erlangen-Nürnberg, Germany
TGF-ß Dependent T-Cell Regulation in Colitis and Colitis-Associated Colon Cancer

Tuesday, March 29 | 5:00PM - 7:00PM
Role of TGF-ß in Inflammation/ Fibrosis I
Room: Longs

Speaker 4 of 5
Jack Gauldie, McMaster University, Canada
TGFbeta and Smad3: Linking Inflammation, Fibrosis, and Emphazema

Tuesday, March 29 | 5:00PM - 7:00PM
Role of TGF-ß in Inflammation/ Fibrosis I
Room: Longs

Speaker 5 of 5
Joanne E. Murphy-Ullrich, University of Alabama at Birmingham, USA
Short Talk: Thrombospondin 1-Dependent TGFbeta Activation in Fibrotic Complications of Diabetes and Hypertension

Tuesday, March 29 | 7:00PM - 8:00PM
Social Hour
Room: Crestone Peak


Tuesday, March 29 | 7:30PM - 10:00PM
Poster Session 1
Room: Grays


Wednesday, March 30 | 7:00AM - 8:00AM
Breakfast
Room: Grays


Wednesday, March 30 | 8:00AM - 11:00AM
Role of TGF-ß in Carcinogenesis I
Room: Longs

Speaker 1 of 5
Lalage M. Wakefield, NCI, National Institutes of Health, USA
'Mechanisms Underlying the Dual Role of TGF-ßs in Breast Cancer: Insights into Tumor Suppressor Mechanisms

Wednesday, March 30 | 8:00AM - 11:00AM
Role of TGF-ß in Carcinogenesis I
Room: Longs

Speaker 2 of 5
* Harold L. Moses, Vanderbilt University, USA
Stromal/Epithelial Interactions in the Role of TGF-ß in Carcinogenesis

Wednesday, March 30 | 8:00AM - 11:00AM
Role of TGF-ß in Carcinogenesis I
Room: Longs

Speaker 3 of 5
Caroline S. Hill, Francis Crick Institute, UK
Modulation of the TGF-ß/Smad Signaling Pathway in Tumorigenesis

Wednesday, March 30 | 8:00AM - 11:00AM
Role of TGF-ß in Carcinogenesis I
Room: Longs

Speaker 4 of 5
Lopa Mishra, George Washington University, USA
Short Talk: Critical Interactions Between TGF-ß Signaling/ELF, and E-Cadherin/ß-catenin Mediated Tumor Suppression

Wednesday, March 30 | 8:00AM - 11:00AM
Role of TGF-ß in Carcinogenesis I
Room: Longs

Speaker 5 of 5
LuZhe Sun, University of Texas Health Science Center, USA
Short Talk: Blockade of Transforming Growth Factor-ß (TGFß) Signaling Inhibits Breast Cancer Metastasis to Bone in an Experimental Animal Model of Bone Metastasis

Wednesday, March 30 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Foyer


Wednesday, March 30 | 11:00AM - 1:00PM
Poster Setup
Room: Grays


Wednesday, March 30 | 1:00PM - 10:00PM
Poster Viewing
Room: Grays


Wednesday, March 30 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Foyer


Wednesday, March 30 | 5:00PM - 7:00PM
Role of TGF-ß in Carcinogenesis II
Room: Longs

Speaker 1 of 4
Theresa A. Guise, Indiana University, USA
Role of TGF-beta in Osteolytic Metastases of Breast Cancer

Wednesday, March 30 | 5:00PM - 7:00PM
Role of TGF-ß in Carcinogenesis II
Room: Longs

Speaker 2 of 4
* Kohei Miyazono, University of Tokyo, Japan
Regulation of TGF-ß Signaling by Inhibitory Smads and Cancer

Wednesday, March 30 | 5:00PM - 7:00PM
Role of TGF-ß in Carcinogenesis II
Room: Longs

Speaker 3 of 4
John J. Letterio, National Cancer Institute, National Institutes of Health, USA
Smad Signaling in T Lymphocytes: Roles in Lymphoid and Epithelial Neoplasia

Wednesday, March 30 | 5:00PM - 7:00PM
Role of TGF-ß in Carcinogenesis II
Room: Longs

Speaker 4 of 4
Jan Pinkas, Genzyme Corporation, USA
Short Talk: Active Treatment with a TGF-ß Neutralizing Antibody Enhances Survival in a Syngeneic Model of Disseminated Breast Cancer with Metastasis to Bone

Wednesday, March 30 | 7:00PM - 8:00PM
Social Hour
Room: Crestone Peak


Wednesday, March 30 | 7:30PM - 10:00PM
Poster Session 2
Room: Grays


Thursday, March 31 | 7:00AM - 8:00AM
Breakfast
Room: Grays


Thursday, March 31 | 8:00AM - 11:00AM
Role of TGF-ß in Inflammation/Fibrosis II
Room: Longs

Speaker 1 of 5
Sushil G. Rane, NIDDK, National Institutes of Health, USA
Short Talk: Function of TGFbeta Signaling in Insulin Synthesis, Secretion and Function

Thursday, March 31 | 8:00AM - 11:00AM
Role of TGF-ß in Inflammation/Fibrosis II
Room: Longs

Speaker 2 of 5
Fernando López-Casillas, Universidad Nacional Autónoma de México, Mexico
Recombinant Soluble Betaglycan and Cyclooxygenase Inhibitors Effectively Control Pulmonary Tuberculosis

Thursday, March 31 | 8:00AM - 11:00AM
Role of TGF-ß in Inflammation/Fibrosis II
Room: Longs

Speaker 3 of 5
José Luis Pablos, Hospital 12 de Octubre, Spain
Short Talk: Topical Application of a Peptide Inhibitor of TGF-ß1 Ameliorates Bleomycin Induced Skin Fibrosis

Thursday, March 31 | 8:00AM - 11:00AM
Role of TGF-ß in Inflammation/Fibrosis II
Room: Longs

Speaker 4 of 5
* Erwin P. Böttinger, Hasso-Plattner-Institut für Digital Engineering GmbH, Germany
TGF-ß and Kidney Disease: Epithelial Apoptosis Before Fibrosis

Thursday, March 31 | 8:00AM - 11:00AM
Role of TGF-ß in Inflammation/Fibrosis II
Room: Longs

Speaker 5 of 5
Ariela Benigni, Istituto di Ricerche Farmacologiche Mario Negri, Italy
Role of Anti-TGF-ß Antibodies in the Treatment of Renal Injury

Thursday, March 31 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Foyer


Thursday, March 31 | 11:00AM - 1:00PM
Poster Setup
Room: Grays


Thursday, March 31 | 1:00PM - 10:00PM
Poster Viewing
Room: Grays


Thursday, March 31 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Foyer


Thursday, March 31 | 5:00PM - 7:00PM
TGF-ß in Response to Cellular Injury
Room: Longs

Speaker 1 of 5
* Mark W.J. Ferguson, Science Foundation Ireland, Ireland

Thursday, March 31 | 5:00PM - 7:00PM
TGF-ß in Response to Cellular Injury
Room: Longs

Speaker 2 of 5
Mary Helen Barcellos-Hoff, New York School of Medicine, USA
TGF-β1 is a Key Mediator of the Cellular DNA Damage Response to Ionizing Radiation

Thursday, March 31 | 5:00PM - 7:00PM
TGF-ß in Response to Cellular Injury
Room: Longs

Speaker 3 of 5
Denis Vivien, University of Caen, Cyceron, France
Neuroprotection Induced by TGFbeta Signaling

Thursday, March 31 | 5:00PM - 7:00PM
TGF-ß in Response to Cellular Injury
Room: Longs

Speaker 4 of 5
Kunxin Luo, University of California, Berkeley, USA
Mechanisms that Regulate Sno N Activity in Fibroblasts and Epithelial Cells

Thursday, March 31 | 5:00PM - 7:00PM
TGF-ß in Response to Cellular Injury
Room: Longs

Speaker 5 of 5
David Danielpour, Case Western Reserve University, USA
Short Talk: IGF-I and Akt Suppress TGF-ß/Smad3 Signals through Both Akt kinase/mTOR-Dependent and Akt kinase-Independent Mechanisms.

Thursday, March 31 | 7:00PM - 8:00PM
Social Hour
Room: Crestone Peak


Thursday, March 31 | 7:30PM - 10:00PM
Poster Session 3
Room: Grays


Friday, April 01 | 7:00AM - 8:00AM
Breakfast
Room: Grays


Friday, April 01 | 8:00AM - 11:00AM
Therapeutic Strategies based on TGF-ß or Antagonists
Room: Longs

Speaker 1 of 5
* John M. McPherson, Genzyme Corporation, USA
Therapeutic Application of TGF-ß Antibodies for the Treatment of Pathological Fibrosis

Friday, April 01 | 8:00AM - 11:00AM
Therapeutic Strategies based on TGF-ß or Antagonists
Room: Longs

Speaker 2 of 5
Mark W.J. Ferguson, Science Foundation Ireland, Ireland
Prevention and Reduction of Scarring in Man by Local Injection of TGFβ3

Friday, April 01 | 8:00AM - 11:00AM
Therapeutic Strategies based on TGF-ß or Antagonists
Room: Longs

Speaker 3 of 5
Karl-Hermann Schlingensiepen, Antisense Pharma GmbH, Germany
Targeted Tumor Therapy with the TGF-beta2 Antisense Compound AP 12009

Friday, April 01 | 8:00AM - 11:00AM
Therapeutic Strategies based on TGF-ß or Antagonists
Room: Longs

Speaker 4 of 5
Ellen H. Filvaroff, Genentech, Inc., USA
Effects of Inhibition of TGF-ß on Tumorigenesis

Friday, April 01 | 8:00AM - 11:00AM
Therapeutic Strategies based on TGF-ß or Antagonists
Room: Longs

Speaker 5 of 5
S. Kyun Lim, University of Wisconsin-Madison, USA
Short Talk: Inhibition of TGF-ß Signaling Using Constrained Peptides and Small Molecules

Friday, April 01 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Foyer


Friday, April 01 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Foyer


Friday, April 01 | 5:00PM - 7:00PM
Therapeutic Strategies for Interfering with TGF-ß Signal Tra
nsduction Pathways

Room: Longs

Speaker 1 of 4
* Jonathan M. Yingling, Idera Pharmaceuticals, Inc., USA
In Vivo Analysis of TGF-ß Receptor Kinase Inhibitors in Fibrosis and Cancer

Friday, April 01 | 5:00PM - 7:00PM
Therapeutic Strategies for Interfering with TGF-ß Signal Tra
nsduction Pathways

Room: Longs

Speaker 2 of 4
Andrew A. Protter, Auransa Inc., USA
ALK5 Kinase Inhibitors for Fibrosis and Cancer

Friday, April 01 | 5:00PM - 7:00PM
Therapeutic Strategies for Interfering with TGF-ß Signal Tra
nsduction Pathways

Room: Longs

Speaker 3 of 4
Nicholas J. Laping, GlaxoSmithKline, USA
ALK5 Kinase Inhibitors as Potential Treatment for Fibrosis and Uterine Fibroids

Friday, April 01 | 5:00PM - 7:00PM
Therapeutic Strategies for Interfering with TGF-ß Signal Tra
nsduction Pathways

Room: Longs

Speaker 4 of 4
Leona E. Ling, Biogen Idec, USA
Short Talk: Therapeutic Activity of a TBR1 Kinase Inhibitor in a Vascular Fibrosis Model

Friday, April 01 | 7:00PM - 8:00PM
Social Hour
Room: Grays


Friday, April 01 | 8:00PM - 11:00PM
Entertainment
Room: Grays


Friday, April 01 | 8:00PM - 11:00PM
Cash Bar
Room: Grays


Saturday, April 02 | 10:26AM - 10:26AM
Departure


*Session Chair.