Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Biology of B Cell Responses (2014Q4)
B Cell Development and Function (2013X1)
B Cells: New Insights into Normal versus Dysregulated Function (2011D6)
B Cells in Context (2009C3)
Biology of B Cells in Health and Disease (2007B5)

Web Desc
B Cell Development, Function and Disease Organizer(s): Harinder Singh, Mark J. Shlomchik and Riccardo Dalla-Favera Date: March 28 - April 03, 2005 Location: Sheraton Steamboat Resort, Steamboat Springs, CO, USA Supported by The Director's Fund Summary of Meeting: The defining feature of B lymphocyte development is the combinatorial recombination of antigen receptor gene segments which results in the generation of a vast repertoire of clonogenic B cells. Each naïve B cell expresses a unique antigen receptor comprised of an antibody molecule associated with signal transduction components. Signaling through the B cell receptor is required for B cell survival, activation in response to antigen and the induction of tolerance. B cell activation in germinal centers is accompanied by somatic hypermutation and isotype switch recombination of immunoglobulin (Ig) genes. The former process is used to select for higher affinity antibodies in an immune response and the latter to generate antibodies with different effector functions. Aberrant B cell activation can result in autoimmune disease or lymphomagenesis. Considerable progress has been recently achieved in several areas including (i) regulation of early B cell development from a lymphoid progenitor, (ii) mechanisms underlying somatic hypermutation and class switching of Ig genes, (iii) signalling functions of the B cell receptor, (iv) analysis of B cell subsets, (v) establishment and functioning of germinal centers (vi) control of plasma cell differentiation and (vii) mechanisms underlying autoimmunity. The meeting represents the continuation of a longstanding forum that uniquely focuses on both murine and human B cell biology so as to promote the analysis of B cell diseases and the generation of new therapeutic approaches. It brings together leading as well as young investigators. Discounted Abstract Deadline: November 29 2004 Discounted Registration Deadline: January 28 2005 We gratefully acknowledge additional support for this conference from: GlaxoSmithKline Research & Development, Ltd. We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

B Cell Development, Function and Disease

Organizer(s): Harinder Singh, Mark J. Shlomchik and Riccardo Dalla-Favera

Date: March 28 - April 03, 2005
Location: Sheraton Steamboat Resort, Steamboat Springs, CO, USA

Supported by The Director's Fund

Summary of Meeting:

The defining feature of B lymphocyte development is the combinatorial recombination of antigen receptor gene segments which results in the generation of a vast repertoire of clonogenic B cells. Each naïve B cell expresses a unique antigen receptor comprised of an antibody molecule associated with signal transduction components. Signaling through the B cell receptor is required for B cell survival, activation in response to antigen and the induction of tolerance. B cell activation in germinal centers is accompanied by somatic hypermutation and isotype switch recombination of immunoglobulin (Ig) genes. The former process is used to select for higher affinity antibodies in an immune response and the latter to generate antibodies with different effector functions. Aberrant B cell activation can result in autoimmune disease or lymphomagenesis. Considerable progress has been recently achieved in several areas including (i) regulation of early B cell development from a lymphoid progenitor, (ii) mechanisms underlying somatic hypermutation and class switching of Ig genes, (iii) signalling functions of the B cell receptor, (iv) analysis of B cell subsets, (v) establishment and functioning of germinal centers (vi) control of plasma cell differentiation and (vii) mechanisms underlying autoimmunity. The meeting represents the continuation of a longstanding forum that uniquely focuses on both murine and human B cell biology so as to promote the analysis of B cell diseases and the generation of new therapeutic approaches. It brings together leading as well as young investigators.

Discounted Abstract Deadline: November 29 2004

Discounted Registration Deadline: January 28 2005

We gratefully acknowledge additional support for this conference from:

GlaxoSmithKline Research & Development, Ltd.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Monday, March 28 \| 3:00PM - 7:30PM Registration Room: Foyer
Monday, March 28 \| 6:30PM - 7:30PM Refreshments Room: Foyer
Monday, March 28 \| 7:30PM - 8:30PM Keynote Address Room: Grand Ballroom Speaker 1 of 1 Max D. Cooper, Emory University, USA The Origin of B and T Cells
Tuesday, March 29 \| 6:30AM - 8:00AM Breakfast Room: 3 Saddles/Sevens/Bear River
Tuesday, March 29 \| 8:00AM - 11:15AM B Cell Development Room: Grand Ballroom Speaker 1 of 6 Richard (Randy) Hardy, Fox Chase Cancer Center, USA Short Talk: Delineating and Characterizing the Earliest Stages in B Cell Development
Tuesday, March 29 \| 8:00AM - 11:15AM B Cell Development Room: Grand Ballroom Speaker 2 of 6 Rudolf Grosschedl, Max Planck Institute of Immunobiology and Epigenetics, Germany Regulation of B Lymphopoiesis by EBF Proteins
Tuesday, March 29 \| 8:00AM - 11:15AM B Cell Development Room: Grand Ballroom Speaker 3 of 6 Cornelis Murre, University of California, San Diego, USA Regulation and Function of HLH Proteins in B Cell Development
Tuesday, March 29 \| 8:00AM - 11:15AM B Cell Development Room: Grand Ballroom Speaker 4 of 6 Meinrad Busslinger, Research Institute of Molecular Pathology, Austria Transcriptional Control of B cell Commitment by Pax5
Tuesday, March 29 \| 8:00AM - 11:15AM B Cell Development Room: Grand Ballroom Speaker 5 of 6 Ana Cumano, Pasteur Institute, France Role of Flk2R and IL-7R Signaling in B Cell Development
Tuesday, March 29 \| 8:00AM - 11:15AM B Cell Development Room: Grand Ballroom Speaker 6 of 6 * Harinder Singh, Cincinnati Children's Hospital Medical Center, USA Short Talk: Gene Regulatory Networks in B Cell Development
Tuesday, March 29 \| 9:20AM - 9:40AM Coffee Break Room: Foyer
Tuesday, March 29 \| 11:00AM - 1:00PM Poster Setup Room: Rainbow/Twilight/Aspen
Tuesday, March 29 \| 1:00PM - 10:00PM Poster Viewing Room: Rainbow/Twilight/Aspen
Tuesday, March 29 \| 2:30PM - 4:00PM Workshop 1: MHC II Signaling and Ag-Presentation Room: Storm Peak Speaker 1 of 7 * Marcus R. Clark, University of Chicago, USA Phosphorylated B Cell Antigen Receptor Complexes are Retained on the Cell Surface Following Receptor Stimulation
Tuesday, March 29 \| 2:30PM - 4:00PM Workshop 1: MHC II Signaling and Ag-Presentation Room: Storm Peak Speaker 2 of 7 Barbara J. Vilen, University of North Carolina at Chapel Hill, USA Independent Trafficking of µm and Ig-alpha/beta is Facilitated by Dissociation of the BCR Complex
Tuesday, March 29 \| 2:30PM - 4:00PM Workshop 1: MHC II Signaling and Ag-Presentation Room: Storm Peak Speaker 3 of 7 Pedro Geraldes, Joslin Diabetes Center, USA Immunoglobulin Heavy Chain and Long Lived B Cells
Tuesday, March 29 \| 2:30PM - 4:00PM Workshop 1: MHC II Signaling and Ag-Presentation Room: Storm Peak Speaker 4 of 7 Pavel Tolar, Francis Crick Institute, UK Probing B-Cell Receptor Structure and Antigen-Induced Clustering by FRET
Tuesday, March 29 \| 2:30PM - 4:00PM Workshop 1: MHC II Signaling and Ag-Presentation Room: Storm Peak Speaker 5 of 7 * Yair Argon, University of Pennsylvania, USA Roles of the Chaperones BiP and GRP94 in Ig Secretion
Tuesday, March 29 \| 2:30PM - 4:00PM Workshop 1: MHC II Signaling and Ag-Presentation Room: Storm Peak Speaker 6 of 7 Boaz Tirosh, Hebrew University, Israel XBP-1 Promotes IgM Synthesis and Secretion, but is Dispensable for Endoplasmic Reticulum Degradation in Primary Plasmablasts
Tuesday, March 29 \| 2:30PM - 4:00PM Workshop 1: MHC II Signaling and Ag-Presentation Room: Storm Peak Speaker 7 of 7 Admar Verschoor, Harvard Medical School, USA Detection of Antigen Trafficking in vivo by Multi-Photon Microscopy
Tuesday, March 29 \| 2:30PM - 4:00PM Workshop 2: B Cell Development Room: Sunshine Peak Speaker 1 of 8 * David M. Allman, University of Pennsylvania, USA
Tuesday, March 29 \| 2:30PM - 4:00PM Workshop 2: B Cell Development Room: Sunshine Peak Speaker 2 of 8 * Barbara Lynne Kee, University of Chicago, USA ID2 is a Major Determinant of Lymphoid Cell Fates
Tuesday, March 29 \| 2:30PM - 4:00PM Workshop 2: B Cell Development Room: Sunshine Peak Speaker 3 of 8 Rachel M. Gerstein, University of Massachusetts Medical School, USA E47 is Required for the Earliest Steps of B Cell Differentiation
Tuesday, March 29 \| 2:30PM - 4:00PM Workshop 2: B Cell Development Room: Sunshine Peak Speaker 4 of 8 Christine A. Goetz, University of North Carolina at Chapel Hill, USA Restricted STAT5 Activation Dictates B Versus T Cell Lineage Commitment
Tuesday, March 29 \| 2:30PM - 4:00PM Workshop 2: B Cell Development Room: Sunshine Peak Speaker 5 of 8 Alessio Delogu, Research Institute of Molecular Pathology, Austria Pax5-Dependent Gene Repression at B-Lineage Commitment is Essential for Normal Hematopoietic Development
Tuesday, March 29 \| 2:30PM - 4:00PM Workshop 2: B Cell Development Room: Sunshine Peak Speaker 6 of 8 Brock L. Schweitzer, University of Cincinnati College of Medicine, USA Ets Transcription Factor Spi-C Interferes with PU.1 Activity in Developing B Cells
Tuesday, March 29 \| 2:30PM - 4:00PM Workshop 2: B Cell Development Room: Sunshine Peak Speaker 7 of 8 Emma M.K. Smith, Lund Stem Cell Center, Sweden Inhibition of EBF Function by Active Notch Signaling Reveals a Novel Regulatory Pathway in Early B-Cell Development
Tuesday, March 29 \| 2:30PM - 4:00PM Workshop 2: B Cell Development Room: Sunshine Peak Speaker 8 of 8 Benjamin C. Harman, Janssen R&D, USA Plasmacytoid Dendritic Cells Derive From Myeloid-Committed Progenitors Which Upregulate Lymphoid-Associated Genes
Tuesday, March 29 \| 4:30PM - 5:00PM Coffee & Snacks Available Room: Foyer
Tuesday, March 29 \| 5:00PM - 7:00PM Signaling and Gene Expression in B Cell Development Room: Grand Ballroom Speaker 1 of 4 * Alexander Tarakhovsky, Rockefeller University, USA Control of Lymphocyte Function by Histone Modifications
Tuesday, March 29 \| 5:00PM - 7:00PM Signaling and Gene Expression in B Cell Development Room: Grand Ballroom Speaker 2 of 4 Robert G. Roeder, Rockefeller University, USA Regulation of B cell Differentiation Events by Transcriptional Coactivators and Corepressors
Tuesday, March 29 \| 5:00PM - 7:00PM Signaling and Gene Expression in B Cell Development Room: Grand Ballroom Speaker 3 of 4 Ranjan Sen, National Institute of Aging, National Institutes of Health, USA Short Talk: Immunoglobulin Heavy Chain Gene Locus Activation
Tuesday, March 29 \| 5:00PM - 7:00PM Signaling and Gene Expression in B Cell Development Room: Grand Ballroom Speaker 4 of 4 Patrick Matthias, Friedrich Miescher Institute for Biomed Research, Switzerland Short Talk: Aiolos and OBF-1 Act in Concert in Early B Lymphocyte Development
Tuesday, March 29 \| 7:00PM - 8:00PM Social Hour Room: Foyer
Tuesday, March 29 \| 7:30PM - 10:00PM Poster Session 1 Room: Rainbow/Twilight/Aspen
Wednesday, March 30 \| 6:30AM - 8:00AM Breakfast Room: 3 Saddles/Sevens/Bear River
Wednesday, March 30 \| 8:00AM - 11:00AM B Cell Activation Room: Grand Ballroom Speaker 1 of 5 * Susan K. Pierce, NIAID, National Institutes of Health, USA The Spatial Organization of B Cell Signaling Receptors
Wednesday, March 30 \| 8:00AM - 11:00AM B Cell Activation Room: Grand Ballroom Speaker 2 of 5 Anthony L. DeFranco, University of California, San Francisco, USA Proximal Events in B Cell Receptor Signaling
Wednesday, March 30 \| 8:00AM - 11:00AM B Cell Activation Room: Grand Ballroom Speaker 3 of 5 John G. Monroe, Genentech, Inc., USA Ligand-Independent Signaling Functions of the B Cell Receptor
Wednesday, March 30 \| 8:00AM - 11:00AM B Cell Activation Room: Grand Ballroom Speaker 4 of 5 John C. Cambier, University of Colorado, USA Anergy: Physiologic Relevance and Underlying Mechanisms
Wednesday, March 30 \| 8:00AM - 11:00AM B Cell Activation Room: Grand Ballroom Speaker 5 of 5 David A. Fruman, University of California, Irvine, USA Short Talk: Transcription Factors That Oppose B Cell Proliferation
Wednesday, March 30 \| 9:20AM - 9:40AM Coffee Break Room: Foyer
Wednesday, March 30 \| 11:00AM - 1:00PM Poster Setup Room: Rainbow/Twilight/Aspen
Wednesday, March 30 \| 1:00PM - 10:00PM Poster Viewing Room: Rainbow/Twilight/Aspen
Wednesday, March 30 \| 2:30PM - 4:00PM Workshop 3: B Cell Signaling Room: Storm Peak Speaker 1 of 8 Claudine Schiff, Centre d'Immunologie de Marseille, France Formation of the Pre-B/Stromal Cell Synapse and its Functional Implication in Pre-B Cell Development
Wednesday, March 30 \| 2:30PM - 4:00PM Workshop 3: B Cell Signaling Room: Storm Peak Speaker 2 of 8 Rudi W. Hendriks, Erasmus MC, Netherlands A Role for Btk Signaling in the Induction of Immunoglobulin Light Chain Rearrangement
Wednesday, March 30 \| 2:30PM - 4:00PM Workshop 3: B Cell Signaling Room: Storm Peak Speaker 3 of 8 * Ananda L. Roy, Tufts University School of Medicine, USA Function of TFII-I in B cells
Wednesday, March 30 \| 2:30PM - 4:00PM Workshop 3: B Cell Signaling Room: Storm Peak Speaker 4 of 8 Tomohiro Kurosaki, Osaka University, Japan Participation of BCAP in Maintenance of Mature B Lymphocytes through Functional Coupling with c-Rel
Wednesday, March 30 \| 2:30PM - 4:00PM Workshop 3: B Cell Signaling Room: Storm Peak Speaker 5 of 8 Henry H. Wortis, Tufts University, USA Regulation of Cytoplasmic Ca2+ Levels by PMCA4b and CD22
Wednesday, March 30 \| 2:30PM - 4:00PM Workshop 3: B Cell Signaling Room: Storm Peak Speaker 6 of 8 * David J. Rawlings, University of Washington, Seattle Children's Hospital Research Institute, USA Molecular Mechanism(s) Controlling PKC-Dependent, Immunoreceptor-Induced NF-kappaB Activation
Wednesday, March 30 \| 2:30PM - 4:00PM Workshop 3: B Cell Signaling Room: Storm Peak Speaker 7 of 8 Shiang-Jong Tzeng, National Taiwan University, Taiwan The Mechanism of FcgammaRIIB1-Mediated Negative Selection of B Lymphocytes: Implications for Autoimmunity
Wednesday, March 30 \| 2:30PM - 4:00PM Workshop 3: B Cell Signaling Room: Storm Peak Speaker 8 of 8 Robert H. Carter, NIAMS, National Institutes of Health, USA The Role of CD19 Signaling in the Germinal Center
Wednesday, March 30 \| 2:30PM - 4:00PM Workshop 4: Autoimmunity Room: Sunshine Peak Speaker 1 of 9 * Chandra Mohan, University of Texas Southwestern Medical Center, USA
Wednesday, March 30 \| 2:30PM - 4:00PM Workshop 4: Autoimmunity Room: Sunshine Peak Speaker 2 of 9 * Ignacio Sanz, Emory University, School of Medicine, USA Regulation of Autoreactive B-Cells
Wednesday, March 30 \| 2:30PM - 4:00PM Workshop 4: Autoimmunity Room: Sunshine Peak Speaker 3 of 9 Carola G. Vinuesa, Australian National University, Australia The Novel Ubiquitin Ligase - Roquin - Represses Follicular T Cells and prevents Autoimmunity
Wednesday, March 30 \| 2:30PM - 4:00PM Workshop 4: Autoimmunity Room: Sunshine Peak Speaker 4 of 9 Sean Christensen, Yale University School of Medicine, USA Toll-like Receptor 9 Controls Anti-DNA Autoantibody Production in Murine Lupus
Wednesday, March 30 \| 2:30PM - 4:00PM Workshop 4: Autoimmunity Room: Sunshine Peak Speaker 5 of 9 Barbara J. Vilen, University of North Carolina at Chapel Hill, USA B Cell Tolerance to Sm is Mediated by Myeloid Dendritic Cells and Macrophages
Wednesday, March 30 \| 2:30PM - 4:00PM Workshop 4: Autoimmunity Room: Sunshine Peak Speaker 6 of 9 Sucai Liu, USA Receptor Editing Can Lead to Allelic Inclusion and Positive Selection of B Cells Reactive with High Avidity Autoantigens
Wednesday, March 30 \| 2:30PM - 4:00PM Workshop 4: Autoimmunity Room: Sunshine Peak Speaker 7 of 9 Laura Mandik-Nayak, Washington University, USA Characterization of Autoreactive B Cell Response in Healthy vs. Arthritic Mice
Wednesday, March 30 \| 2:30PM - 4:00PM Workshop 4: Autoimmunity Room: Sunshine Peak Speaker 8 of 9 Eric Meffre, Yale University School of Medicine, USA Impaired Early B Cell Tolerance in Patients with Rheumatoid Arthritis
Wednesday, March 30 \| 2:30PM - 4:00PM Workshop 4: Autoimmunity Room: Sunshine Peak Speaker 9 of 9 Sooghee Chang, University of Texas Southwestern Medical Center, USA Origins of Antinuclear Antibodies – Genetically Programmed Selection of Antibodies with Peculiar CDR Charge Motifs into the Primary Immunoglobulin Repertoire
Wednesday, March 30 \| 4:30PM - 5:00PM Coffee & Snacks Available Room: Foyer
Wednesday, March 30 \| 5:00PM - 7:00PM B Cell Subsets and Geminal Centers Room: Grand Ballroom Speaker 1 of 4 * John F. Kearney, University of Alabama, Birmingham, USA Marginal Zone B-lymphocytes: Development and Function.
Wednesday, March 30 \| 5:00PM - 7:00PM B Cell Subsets and Geminal Centers Room: Grand Ballroom Speaker 2 of 4 Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany V Region Repertoires Generated by VH to JH Joining and VH Replacement
Wednesday, March 30 \| 5:00PM - 7:00PM B Cell Subsets and Geminal Centers Room: Grand Ballroom Speaker 3 of 4 Jeffrey L. Browning, Boston University School of Medicine, USA Short Talk: Effects of FDC Dissolution on Ig Responses in Normal Mice
Wednesday, March 30 \| 5:00PM - 7:00PM B Cell Subsets and Geminal Centers Room: Grand Ballroom Speaker 4 of 4 Frederick W. Alt, Boston Children's Hospital, USA AID and DNA Deamination in Antibody Gene Diversification.
Wednesday, March 30 \| 7:00PM - 8:00PM Social Hour Room: Foyer
Wednesday, March 30 \| 7:30PM - 10:00PM Poster Session 2 Room: Rainbow/Twilight/Aspen
Thursday, March 31 \| 6:30AM - 8:00AM Breakfast Room: 3 Saddles/Sevens/Bear River
Thursday, March 31 \| 8:00AM - 11:00AM Somatic Hypermutation, Class Switching and VDJ Recombination Room: Grand Ballroom Speaker 1 of 6 * Tasuku Honjo, Kyoto University Graduate School of Medicine, Japan AID: How Does it Aid Antibody Diversity?
Thursday, March 31 \| 8:00AM - 11:00AM Somatic Hypermutation, Class Switching and VDJ Recombination Room: Grand Ballroom Speaker 2 of 6 Michael S. Neuberger, Medical Research Council, UK Antibody Somatic Hypermutation and DNA Deamination
Thursday, March 31 \| 8:00AM - 11:00AM Somatic Hypermutation, Class Switching and VDJ Recombination Room: Grand Ballroom Speaker 3 of 6 Janet M. Stavnezer, University of Massachusetts Medical School, USA Short Talk: AID-Dependent DNA Breaks during Antibody Class Switching
Thursday, March 31 \| 8:00AM - 11:00AM Somatic Hypermutation, Class Switching and VDJ Recombination Room: Grand Ballroom Speaker 4 of 6 Michael R. Lieber, University of Southern California, USA Non-B DNA Structures and NHEJ in Physiologic and Pathologic Gene Rearrangements
Thursday, March 31 \| 8:00AM - 11:00AM Somatic Hypermutation, Class Switching and VDJ Recombination Room: Grand Ballroom Speaker 5 of 6 David B. Roth, New York University School of Medicine, USA Short Talk: The Recombinase as Gatekeeper Linking V(D)J REcombination to DNA Repair
Thursday, March 31 \| 8:00AM - 11:00AM Somatic Hypermutation, Class Switching and VDJ Recombination Room: Grand Ballroom Speaker 6 of 6 Jane A. Skok, New York University School of Medicine, USA Short Talk: Allelic Exclusion: The Contribution of Locus Decontraction and Centromeric Recruitment
Thursday, March 31 \| 9:20AM - 9:40AM Coffee Break Room: Foyer
Thursday, March 31 \| 11:00AM - 1:00PM Poster Setup Room: Rainbow/Twilight/Aspen
Thursday, March 31 \| 1:00PM - 10:00PM Poster Viewing Room: Rainbow/Twilight/Aspen
Thursday, March 31 \| 2:30PM - 4:00PM Workshop 5: VDJ Recombination, Somatic Hypermutation, and Is otype Switching Room: Sunshine Peak Speaker 1 of 10 * Eugene M. Oltz, Vanderbilt University School of Medicine, USA Accessibility Control of V(D)J Recombination by Promoter/Enhancer Crosstalk
Thursday, March 31 \| 2:30PM - 4:00PM Workshop 5: VDJ Recombination, Somatic Hypermutation, and Is otype Switching Room: Sunshine Peak Speaker 2 of 10 Ann J. Feeney, The Scripps Research Institute, USA Correlation between the Level of Histone Acetylation and VH Gene Rearrangement Frequency
Thursday, March 31 \| 2:30PM - 4:00PM Workshop 5: VDJ Recombination, Somatic Hypermutation, and Is otype Switching Room: Sunshine Peak Speaker 3 of 10 Anne E. Corcoran, Babraham Institute, UK Antisense Intergenic Transcription: A General Role in Ordered V(D)J Recombination
Thursday, March 31 \| 2:30PM - 4:00PM Workshop 5: VDJ Recombination, Somatic Hypermutation, and Is otype Switching Room: Sunshine Peak Speaker 4 of 10 Eric Bertolino, University of Chicago, USA Regulation of IL-7 Dependent Immunoglobulin VH Gene Rearrangements by Stat5
Thursday, March 31 \| 2:30PM - 4:00PM Workshop 5: VDJ Recombination, Somatic Hypermutation, and Is otype Switching Room: Sunshine Peak Speaker 5 of 10 Lisa Borghesi, University of Pittsburgh, USA Distinct Effects of E47 on Development and Differentiation of Common Lymphoid Progenitors
Thursday, March 31 \| 2:30PM - 4:00PM Workshop 5: VDJ Recombination, Somatic Hypermutation, and Is otype Switching Room: Sunshine Peak Speaker 6 of 10 Katheryn D. Meek, Michigan State University, USA Separate Clusters of Autophosphorylation Sites in DNA-PKcs Regulate Distinct Steps in DNA End Processing
Thursday, March 31 \| 2:30PM - 4:00PM Workshop 5: VDJ Recombination, Somatic Hypermutation, and Is otype Switching Room: Sunshine Peak Speaker 7 of 10 * Amy L. Kenter, University of Illinois College of Medicine, USA Chromatin Modification in S Regions is Dependent on AID
Thursday, March 31 \| 2:30PM - 4:00PM Workshop 5: VDJ Recombination, Somatic Hypermutation, and Is otype Switching Room: Sunshine Peak Speaker 8 of 10 Ursula Storb, University of Chicago, USA Mechanism of Somatic Hypermutation of Immunoglobulin Genes
Thursday, March 31 \| 2:30PM - 4:00PM Workshop 5: VDJ Recombination, Somatic Hypermutation, and Is otype Switching Room: Sunshine Peak Speaker 9 of 10 Patricia J. Gearhart, NIA, National Institutes of Health, USA MSH2-MSH6 Stimulates DNA Polymerase Eta, Suggesting a Role for A:T Mutations in Antibody Genes
Thursday, March 31 \| 2:30PM - 4:00PM Workshop 5: VDJ Recombination, Somatic Hypermutation, and Is otype Switching Room: Sunshine Peak Speaker 10 of 10 Andrea Bottaro, University of Rochester School of Medicine and Dentistry, USA Functional Phylogenetics of Activation-Induced Deaminase
Thursday, March 31 \| 2:30PM - 4:00PM Workshop 6: B Cell Subsets and Homeostasis Room: Storm Peak Speaker 1 of 8 * Stephen H. Clarke, University of North Carolina at Chapel Hill, USA Pre-Plasma Cells Define a Checkpoint for Autoreactive B Cells in Normal Mice
Thursday, March 31 \| 2:30PM - 4:00PM Workshop 6: B Cell Subsets and Homeostasis Room: Storm Peak Speaker 2 of 8 * Shiv Pillai, Massachusetts General Hospital, USA The BCR Drives Lineage Commitment during B Lymphocyte Development
Thursday, March 31 \| 2:30PM - 4:00PM Workshop 6: B Cell Subsets and Homeostasis Room: Storm Peak Speaker 3 of 8 Rachel A. Liberatore, Columbia University, USA c-Abl Signaling Contributes to the Generation of Peritoneal B-1 Cells
Thursday, March 31 \| 2:30PM - 4:00PM Workshop 6: B Cell Subsets and Homeostasis Room: Storm Peak Speaker 4 of 8 Robert Berland, Tufts University, USA Targeted Deletion of the CD5 Enhancer
Thursday, March 31 \| 2:30PM - 4:00PM Workshop 6: B Cell Subsets and Homeostasis Room: Storm Peak Speaker 5 of 8 Ramon Roozendaal, Crucell, Netherlands Identification of a Novel C4 Receptor Expressed on Subsets of Mouse B-Cells
Thursday, March 31 \| 2:30PM - 4:00PM Workshop 6: B Cell Subsets and Homeostasis Room: Storm Peak Speaker 6 of 8 David Mark Mills, Arena Pharmaceuticals, USA Regulation of ICOSL Expression/Signaling by BAFF
Thursday, March 31 \| 2:30PM - 4:00PM Workshop 6: B Cell Subsets and Homeostasis Room: Storm Peak Speaker 7 of 8 Sarah F. Andrews, National Institutes of Health, USA BAFF Promotes Formation of a Functionally Mature B-Cell Receptor
Thursday, March 31 \| 2:30PM - 4:00PM Workshop 6: B Cell Subsets and Homeostasis Room: Storm Peak Speaker 8 of 8 Bhaskar Srivastava, University of Pennsylvania, USA Lymphopenia Induces Development of Marginal Zone B Cells from Follicular B Cells
Thursday, March 31 \| 4:30PM - 5:00PM Coffee & Snacks Available Room: Foyer
Thursday, March 31 \| 5:00PM - 7:00PM B Cell Transformation Mechanisms Room: Grand Ballroom Speaker 4 of 4 David G. Schatz, Yale University School of Medicine, USA Short Talk: Histone Modification in Somatic Hypermutation and Class Switching
Thursday, March 31 \| 5:00PM - 7:00PM B Cell Transformation Mechanisms Room: Grand Ballroom Speaker 3 of 4 * Riccardo Dalla-Favera, Columbia University, USA Molecular Pathogenesis of B Cell Lymphomas
Thursday, March 31 \| 5:00PM - 7:00PM B Cell Transformation Mechanisms Room: Grand Ballroom Speaker 2 of 4 Louis M. Staudt, NCI, National Institutes of Health, USA Molecular Profiling of Human Lymphomas and Myelomas
Thursday, March 31 \| 5:00PM - 7:00PM B Cell Transformation Mechanisms Room: Grand Ballroom Speaker 1 of 4 André Nussenzweig, NCI, National Institutes of Health, USA Chromatin Dynamics at DNA Double Strand Breaks
Thursday, March 31 \| 7:00PM - 8:00PM Social Hour Room: Foyer
Thursday, March 31 \| 7:30PM - 10:00PM Poster Session 3 Room: Rainbow/Twilight/Aspen
Friday, April 01 \| 6:30AM - 8:00AM Breakfast Room: 3 Saddles/Sevens/Bear River
Friday, April 01 \| 8:00AM - 11:15AM Affinity Maturation and Memory B Cells Room: Grand Ballroom Speaker 6 of 6 Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland Exploring and Exploiting Human B Cell Memory
Friday, April 01 \| 8:00AM - 11:15AM Affinity Maturation and Memory B Cells Room: Grand Ballroom Speaker 5 of 6 David M. Tarlinton, Monash University, Australia Short Talk: The Germinal Center to Plasma Cell Transition
Friday, April 01 \| 8:00AM - 11:15AM Affinity Maturation and Memory B Cells Room: Grand Ballroom Speaker 4 of 6 Michael G. McHeyzer-Williams, The Scripps Research Institute, USA Antigen-Specific Memory B Cell Subsets
Friday, April 01 \| 8:00AM - 11:15AM Affinity Maturation and Memory B Cells Room: Grand Ballroom Speaker 3 of 6 Takaharu Okada, RIKEN, Japan Short Talk: Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells
Friday, April 01 \| 8:00AM - 11:15AM Affinity Maturation and Memory B Cells Room: Grand Ballroom Speaker 2 of 6 Thomas J. Waldschmidt, University of Iowa, USA Regulation of the Germinal Center Response in Normal and Autoimmune Mice
Friday, April 01 \| 8:00AM - 11:15AM Affinity Maturation and Memory B Cells Room: Grand Ballroom Speaker 1 of 6 * Garnett H. Kelsoe, Duke University and Medical Center, USA Inflammation, Affinity Maturation, and Extramedullary Lymphopoiesis
Friday, April 01 \| 9:20AM - 9:40AM Coffee Break Room: Foyer
Friday, April 01 \| 11:00AM - 1:00PM Poster Setup Room: Rainbow/Twilight/Aspen
Friday, April 01 \| 1:00PM - 10:00PM Poster Viewing Room: Rainbow/Twilight/Aspen
Friday, April 01 \| 2:30PM - 4:00PM Workshop 7: B Cell Malignancy Room: Storm Peak Speaker 2 of 9 Maxime Hervé, Novartis Institute for Tropical Disease, Singapore Unmutated and Mutated Chronic Lymphocytic Leukemia B Cells Derive from Common Self-Reactive B Cell Precursors Despite Expressing Different Antibody Reactivity
Friday, April 01 \| 2:30PM - 4:00PM Workshop 7: B Cell Malignancy Room: Storm Peak Speaker 1 of 9 * Nicholas Chiorazzi, Feinstein Institute for Medical Research, USA
Friday, April 01 \| 2:30PM - 4:00PM Workshop 7: B Cell Malignancy Room: Storm Peak Speaker 3 of 9 Carel J. M. van Noesel, Academic Medical Center, Netherlands Antigen Receptors of Mature B-cell non Hodgkin’s Lymphomas: MALT Lymphomas Express a Distinctive Antibody Repertoire with Frequent Autoreactivity
Friday, April 01 \| 2:30PM - 4:00PM Workshop 7: B Cell Malignancy Room: Storm Peak Speaker 4 of 9 Wendy F. Davidson, NIAID, National Institutes of Health, USA Evidence for Selective Transformation of Autoreactive Immature Plasma Cells in Mice Deficient in Fasl
Friday, April 01 \| 2:30PM - 4:00PM Workshop 7: B Cell Malignancy Room: Storm Peak Speaker 5 of 9 * Ralf Küppers, University of Duisburg-Essen, Medical School, Germany Aberrant Expression and Activation of Multiple Receptor Tyrosine Kinases in Classical Hodgkin Lymphoma
Friday, April 01 \| 2:30PM - 4:00PM Workshop 7: B Cell Malignancy Room: Storm Peak Speaker 6 of 9 Demin Wang, Blood Research Institute, Milwaukee, WI, USA Phospholipase Cgamma2 Deficiency Accelerates Myc-Mediated Proliferation and Lymphomagenesis
Friday, April 01 \| 2:30PM - 4:00PM Workshop 7: B Cell Malignancy Room: Storm Peak Speaker 7 of 9 Davide F. Robbiani, Rockefeller University, USA Somatic Activation of MYC and BCL6 Induces Multiple Myeloma and Diffuse Lymphoma in Mice
Friday, April 01 \| 2:30PM - 4:00PM Workshop 7: B Cell Malignancy Room: Storm Peak Speaker 8 of 9 Rhine R. Shen, Dana-Farber Cancer Institute, USA TCL1 Augments Activation Induced Cytidine Deaminase (AID) Expression in Support of Germinal Center B Cell Transformation
Friday, April 01 \| 2:30PM - 4:00PM Workshop 7: B Cell Malignancy Room: Storm Peak Speaker 9 of 9 Laura Pasqualucci, Columbia University, USA Extent and Mechanism of Aberrant Somatic Hypermutation in Diffuse Large B-Cell Lymphoma
Friday, April 01 \| 2:30PM - 4:00PM Workshop 8: B Cell Immune Responses Room: Sunshine Peak Speaker 1 of 8 * Lynn M. Corcoran, Walter and Eliza Hall Institute of Medical Research, Australia Differential Requirement for OBF-1 during Antibody Secreting Cell Differentiation
Friday, April 01 \| 2:30PM - 4:00PM Workshop 8: B Cell Immune Responses Room: Sunshine Peak Speaker 2 of 8 * Andreas Radbruch, Deutsches Rheuma-Forschungszentrum, Germany Competition and Compartmentalization of Plasmablasts and Plasma Cells
Friday, April 01 \| 2:30PM - 4:00PM Workshop 8: B Cell Immune Responses Room: Sunshine Peak Speaker 3 of 8 Nicholas D. Huntington, Walter and Eliza Hall Institute, WEHI, Australia Dissecting the Requirement for BCR Signals in T-D Immune Responses
Friday, April 01 \| 2:30PM - 4:00PM Workshop 8: B Cell Immune Responses Room: Sunshine Peak Speaker 4 of 8 Falk Hiepe, Charité - Universitätsmedizin Berlin, Germany Long-Lived Plasma Cells Contribute Significantly to Autoantibody Production in Systemic Lupus Erythematosus (SLE) and Represent a Novel and Essential Target for Cellular Therapies
Friday, April 01 \| 2:30PM - 4:00PM Workshop 8: B Cell Immune Responses Room: Sunshine Peak Speaker 5 of 8 Shane Crotty, La Jolla Institute for Immunology, USA Long Term B Cell Memory in Humans After Smallpox Vaccination
Friday, April 01 \| 2:30PM - 4:00PM Workshop 8: B Cell Immune Responses Room: Sunshine Peak Speaker 6 of 8 Thierry C. Defrance, INSERM, France The Endoplasmic Reticulum is the Central Executioner of Plasma Cell Death
Friday, April 01 \| 2:30PM - 4:00PM Workshop 8: B Cell Immune Responses Room: Sunshine Peak Speaker 7 of 8 Rachel Ettinger, Viela Bio, USA IL-21 Drives Terminal Differentiation of Human Naïve B Cells into Antibody Secreting Plasma Cells
Friday, April 01 \| 2:30PM - 4:00PM Workshop 8: B Cell Immune Responses Room: Sunshine Peak Speaker 8 of 8 Anatoly V. Rubtsov, University of Colorado Health Sciences Center, USA Lsc Regulates Marginal Zone B Cell Migration and Adhesion and is Necessary for the IgM T-Dependent Primary Antibody Response
Friday, April 01 \| 4:30PM - 5:00PM Coffee & Snacks Available Room: Foyer
Friday, April 01 \| 5:00PM - 7:00PM Plasma Cells Room: Grand Ballroom Speaker 1 of 5 Hergen Spits, University of Amsterdam, Netherlands Short Talk: Role of Stat5 in Human Memory B Cell Development
Friday, April 01 \| 5:00PM - 7:00PM Plasma Cells Room: Grand Ballroom Speaker 2 of 5 * Kathryn L. Calame, Columbia College of Physicians and Surgeons, USA The Roles of B Lymphocyte Induced Maturation Protein in Lymphocyte Differentiation
Friday, April 01 \| 5:00PM - 7:00PM Plasma Cells Room: Grand Ballroom Speaker 3 of 5 Linda M. Hendershot, St. Jude Children's Research Hospital, USA Plasma Cell Differentiation and the Unfolded Protein Response
Friday, April 01 \| 5:00PM - 7:00PM Plasma Cells Room: Grand Ballroom Speaker 4 of 5 Stuart G. Tangye, Garvan Institute of Medical Research, Australia Short Talk: Plasma Cell Differentiation in Humans
Friday, April 01 \| 5:00PM - 7:00PM Plasma Cells Room: Grand Ballroom Speaker 5 of 5 Paul A. Wade, NIEHS, National Institutes of Health, USA Short Talk: MTA3 in GC and B Cell Differentiation
Friday, April 01 \| 7:00PM - 8:00PM Social Hour Room: Foyer
Friday, April 01 \| 7:30PM - 10:00PM Poster Session 4 Room: Rainbow/Twilight/Aspen
Saturday, April 02 \| 6:30AM - 8:00AM Breakfast Room: 3 Saddles/Sevens/Bear River
Saturday, April 02 \| 8:00AM - 11:00AM B Cells, Autoimmunity, and Immunodeficiency Room: Grand Ballroom Speaker 1 of 5 Ann Marshak-Rothstein, University of Massachusetts Medical School, USA Toll-like Receptor Signaling in Systemic Autoimune Disease
Saturday, April 02 \| 8:00AM - 11:00AM B Cells, Autoimmunity, and Immunodeficiency Room: Grand Ballroom Speaker 2 of 5 Jan S. Erikson, Wistar Institute, USA The Regulation and Activation of Lupus-Associated B Cells
Saturday, April 02 \| 8:00AM - 11:00AM B Cells, Autoimmunity, and Immunodeficiency Room: Grand Ballroom Speaker 3 of 5 Martin G. Weigert, University of Chicago, USA Anti-DNA Antibodies and Autoimmunity
Saturday, April 02 \| 8:00AM - 11:00AM B Cells, Autoimmunity, and Immunodeficiency Room: Grand Ballroom Speaker 4 of 5 * Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA Activation and Regulation of Autoreactive B Cells in vivo
Saturday, April 02 \| 8:00AM - 11:00AM B Cells, Autoimmunity, and Immunodeficiency Room: Grand Ballroom Speaker 5 of 5 Timothy W. Behrens, Genentech, Inc., USA Short Talk: Signaling through the BCR Shuts Off Receptor Editing
Saturday, April 02 \| 9:20AM - 9:40AM Coffee Break Room: Foyer
Saturday, April 02 \| 4:30PM - 5:00PM Coffee & Snacks Available Room: Foyer
Saturday, April 02 \| 5:00PM - 7:00PM B Cell Tolerance Room: Grand Ballroom Speaker 1 of 4 Carola G. Vinuesa, Australian National University, Australia Tolerogenic Signaling in B Cells
Saturday, April 02 \| 5:00PM - 7:00PM B Cell Tolerance Room: Grand Ballroom Speaker 2 of 4 Kyoko Hayakawa, Fox Chase Cancer Center, USA Selection of B-1 B Cells Producing Natural Autoantibody
Saturday, April 02 \| 5:00PM - 7:00PM B Cell Tolerance Room: Grand Ballroom Speaker 3 of 4 * Michel C. Nussenzweig, HHMI/Rockefeller University, USA Development of Autoantibodies in Normal Humans and in Patients with SLE
Saturday, April 02 \| 5:00PM - 7:00PM B Cell Tolerance Room: Grand Ballroom Speaker 4 of 4 Gregg J. Silverman, New York University Langone Medical Center, USA Short Talk: Peripheral B Cell Tolerance
Saturday, April 02 \| 8:00PM - 9:00PM Social Hour Room: Foyer/Grand Ballroom
Saturday, April 02 \| 8:00PM - 11:00PM Entertainment Room: Grand Ballroom
Saturday, April 02 \| 8:00PM - 11:00PM Cash Bar Room: Grand Ballroom
Sunday, April 03 \| 10:26AM - 10:26AM Departure *Session Chair.