Web Desc
Axonal Connections: Molecular Cues for Development and Regeneration
Organizer(s): Stephen M. Strittmatter, Marc Tessier-Lavigne and John G. Flanagan
Date: March 31 - April 04, 2005
Location: Beaver Run Resort, Breckenridge, CO, USA
Supported by The Director's Fund
Summary of Meeting:
The functioning of the nervous system depends on its complex pattern of connections. Axonal connections are initially set up during development by cues, which guide axons along specific pathways, and then specify connection sites within the target region. In recent years, dramatic progress has been made in identifying such cues molecularly. Based on this progress, current studies are elucidating the molecular logic of extracellular signals that set up connectivity, as well as intracellular pathways that interpret these signals. In the adult central nervous system, damaged axonal connections do not regenerate, even though peripheral nerves can regenerate efficiently. This is due at least in part to CNS inhibitors, some of which have now been cloned. This meeting will bring together the fields of development and regeneration, with the goal of facilitating synergistic overlaps in techniques, molecules and biology. Topics will include basic research on molecular cues, and resulting new approaches toward therapeutic axon repair.
Discounted Abstract Deadline: November 30 2004
Discounted Registration Deadline: January 31 2005
We gratefully acknowledge additional support for this conference from:

Biogen Idec
March of Dimes FoundationNational Multiple Sclerosis Society
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, March 31 | 3:00PM - 7:30PM
Registration
Room: Foyer


Thursday, March 31 | 6:30PM - 7:30PM
Refreshments
Room: Foyer


Thursday, March 31 | 7:30PM - 8:30PM
Keynote Address
Room: Peaks 4-5

Speaker 1 of 1
Marc Tessier-Lavigne, Stanford University, USA
Molecular Mechanisms of Axon Growth, Guidance and Regeneration

Friday, April 01 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Friday, April 01 | 8:00AM - 11:00AM
Pathway Selection and Choice Points
Room: Peaks 4-5

Speaker 1 of 6
* Marc Tessier-Lavigne, Stanford University, USA

Friday, April 01 | 8:00AM - 11:00AM
Pathway Selection and Choice Points
Room: Peaks 4-5

Speaker 2 of 6
Christine E. Holt, University of Cambridge, UK
Directional Guidance and Local Translation in Retinal Growth Cones

Friday, April 01 | 8:00AM - 11:00AM
Pathway Selection and Choice Points
Room: Peaks 4-5

Speaker 3 of 6
Carol Ann Mason, Columbia University, USA
Genes that Pattern the Retina and Diencephalon during Optic Chiasm Formation

Friday, April 01 | 8:00AM - 11:00AM
Pathway Selection and Choice Points
Room: Peaks 4-5

Speaker 4 of 6
Oliver Hobert, Columbia University, USA
Sugar Coding the Nervous System: The Role of Secondary Modifications of Proteoglycans in Axon Guidance Choices

Friday, April 01 | 8:00AM - 11:00AM
Pathway Selection and Choice Points
Room: Peaks 4-5

Speaker 5 of 6
Till Marquardt, The Salk Institute for Biological Studies, USA
Short Talk: Eph-Ephrin Mediated Signaling Mechanisms Directing Spinal Motor Axon Targeting

Friday, April 01 | 8:00AM - 11:00AM
Pathway Selection and Choice Points
Room: Peaks 4-5

Speaker 6 of 6
Yimin Zou, University of California, San Diego, USA
Short Talk: A Diffusible Guidance cue, Wnt3, is a Candidate
Opposing Signal for Medial-Lateral Retinotectal Mapping


Friday, April 01 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Friday, April 01 | 11:00AM - 1:00PM
Poster Setup
Room: Peaks 1-3


Friday, April 01 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-3


Friday, April 01 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Friday, April 01 | 4:45PM - 7:00PM
Target Recognition
Room: Peaks 4-5

Speaker 1 of 5
* Rüdiger Klein, Max Planck Institute of Neurobiology, Germany

Friday, April 01 | 4:45PM - 7:00PM
Target Recognition
Room: Peaks 4-5

Speaker 2 of 5
Azad Bonni, Harvard Medical School, USA
Cdh1-APC Control of Axonal Growth and Patterning in the Mammalian Brain

Friday, April 01 | 4:45PM - 7:00PM
Target Recognition
Room: Peaks 4-5

Speaker 3 of 5
Hollis T. Cline, The Scripps Research Institute, USA
Regulation of Terminal Branching


Friday, April 01 | 4:45PM - 7:00PM
Target Recognition
Room: Peaks 4-5

Speaker 4 of 5
Joshua R. Sanes, Harvard University, USA
Synapse Formation: Coordinating Pre- And Postsynaptic Differentiation

Friday, April 01 | 4:45PM - 7:00PM
Target Recognition
Room: Peaks 4-5

Speaker 5 of 5
Karel Svoboda, Janelia Research Campus & Cold Spring Harbor Laboratory, USA
Experience-Dependent Structural Plasticity in the Adult Neocortex in vivo

Friday, April 01 | 7:00PM - 8:00PM
Social Hour
Room: Peaks 1-3


Friday, April 01 | 7:30PM - 10:00PM
Poster Session 1
Room: Peaks 1-3


Saturday, April 02 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Saturday, April 02 | 8:00AM - 11:15AM
Inhibitors of Regeneration
Room: Peaks 4-5

Speaker 1 of 6
* Marc Tessier-Lavigne, Stanford University, USA

Saturday, April 02 | 8:00AM - 11:15AM
Inhibitors of Regeneration
Room: Peaks 4-5

Speaker 2 of 6
Stephen B. McMahon, King's College London, UK
Proteoglycans, plasticity and spinal cord repair

Saturday, April 02 | 8:00AM - 11:15AM
Inhibitors of Regeneration
Room: Peaks 4-5

Speaker 3 of 6
Martin E. Schwab, University of Zürich, Switzerland
Nogo-A, a regulator of regeneration, neurite growth and circuit stability

Saturday, April 02 | 8:00AM - 11:15AM
Inhibitors of Regeneration
Room: Peaks 4-5

Speaker 4 of 6
Marie T. Filbin, Hunter College, USA
Myelin Inhibitors of Regeneration: How They Work and How to Overcome Them.

Saturday, April 02 | 8:00AM - 11:15AM
Inhibitors of Regeneration
Room: Peaks 4-5

Speaker 5 of 6
Stephen M. Strittmatter, Yale University, USA
Nogo and NgR in Adult CNS Axonal Regeneration and Plasticity

Saturday, April 02 | 8:00AM - 11:15AM
Inhibitors of Regeneration
Room: Peaks 4-5

Speaker 6 of 6
Karthik Venkatesh, University of Rochester School of Medicine and Dentistry, USA
Short Talk: NgR2 is a Novel MAG Receptor: Insights into the Structural Basis of Receptor Function and Specificity

Saturday, April 02 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Saturday, April 02 | 11:00AM - 1:00PM
Poster Setup
Room: Peaks 1-3


Saturday, April 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-3


Saturday, April 02 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Saturday, April 02 | 4:45PM - 7:00PM
Extracellular Signals Regulating Axonal Growth
Room: Peaks 4-5

Speaker 1 of 5
* Joshua R. Sanes, Harvard University, USA

Saturday, April 02 | 4:45PM - 7:00PM
Extracellular Signals Regulating Axonal Growth
Room: Peaks 4-5

Speaker 2 of 5
M. Douglas Benson, University of Texas Southwestern Medical Center, USA
Short Talk: Ephrin-B3 is a Myelin-Based Inhibitor of Neurite Outgrowth

Saturday, April 02 | 4:45PM - 7:00PM
Extracellular Signals Regulating Axonal Growth
Room: Peaks 4-5

Speaker 3 of 5
Rüdiger Klein, Max Planck Institute of Neurobiology, Germany
Ephrins and Eph Receptors in Neural Development

Saturday, April 02 | 4:45PM - 7:00PM
Extracellular Signals Regulating Axonal Growth
Room: Peaks 4-5

Speaker 4 of 5
David L. Van Vactor, Harvard Medical School, USA
Syndecan Promotes Synapse Growth Through Interactions with the Receptor Phosphatase LAR.

Saturday, April 02 | 4:45PM - 7:00PM
Extracellular Signals Regulating Axonal Growth
Room: Peaks 4-5

Speaker 5 of 5
Alex L. Kolodkin, Johns Hopkins University School of Medicine, USA
Semaphorin Function in Drosophila and Vertebrates

Saturday, April 02 | 7:00PM - 8:00PM
Social Hour
Room: Peaks 1-3


Saturday, April 02 | 7:30PM - 10:00PM
Poster Session 2
Room: Peaks 1-3


Sunday, April 03 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Sunday, April 03 | 8:00AM - 11:00AM
Pathways Downstream of Axonal Receptors
Room: Peaks 4-5

Speaker 1 of 6
* Stephen M. Strittmatter, Yale University, USA

Sunday, April 03 | 8:00AM - 11:00AM
Pathways Downstream of Axonal Receptors
Room: Peaks 4-5

Speaker 2 of 6
Yuh-Nung Jan, University of California, San Francisco, USA
Comparison of Axon and Dendrite Patterning and Remodeling


Sunday, April 03 | 8:00AM - 11:00AM
Pathways Downstream of Axonal Receptors
Room: Peaks 4-5

Speaker 3 of 6
Michael E. Greenberg, Harvard Medical School, USA
Distinct roles for Dbl family GEFs in ephrin-mediated growth cone repulsion

Sunday, April 03 | 8:00AM - 11:00AM
Pathways Downstream of Axonal Receptors
Room: Peaks 4-5

Speaker 4 of 6
Mu-ming Poo, Institute of Neuroscience, CAS, China
Ca2+ Signaling in Growth Cone Guidance and Directed Neuronal Migration

Sunday, April 03 | 8:00AM - 11:00AM
Pathways Downstream of Axonal Receptors
Room: Peaks 4-5

Speaker 5 of 6
Zhigang He, Children's Hospital, Boston, USA
Mechanisms of CNS Growth Inhibition by Myelin Inhibitors

Sunday, April 03 | 8:00AM - 11:00AM
Pathways Downstream of Axonal Receptors
Room: Peaks 4-5

Speaker 6 of 6
Katharine J.M. Marler, King's College London, UK
Short Talk: Neurite Repulsion by Chondroitin Sulphate Proteoglycan or Tenascin Requires PAK

Sunday, April 03 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Sunday, April 03 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Sunday, April 03 | 4:45PM - 7:00PM
Signals in Degeneration and Regeneration
Room: Peaks 4-5

Speaker 1 of 4
* Michael E. Greenberg, Harvard Medical School, USA

Sunday, April 03 | 4:45PM - 7:00PM
Signals in Degeneration and Regeneration
Room: Peaks 4-5

Speaker 2 of 4
Liqun Luo, Stanford University, USA
Developmental Axon Pruning through Axon Degeneration

Sunday, April 03 | 4:45PM - 7:00PM
Signals in Degeneration and Regeneration
Room: Peaks 4-5

Speaker 3 of 4
Ben A. Barres, Stanford University, USA
Why is Wallerian Degeneration so Slow in the CNS?

Sunday, April 03 | 4:45PM - 7:00PM
Signals in Degeneration and Regeneration
Room: Peaks 4-5

Speaker 4 of 4
Clifford J. Woolf, Children's Hospital, USA
Master switches that determine intrinsic growth in adult neurons

Sunday, April 03 | 7:00PM - 8:00PM
Social Hour
Room: Peaks 1-3


Sunday, April 03 | 8:00PM - 11:00PM
Entertainment
Room: Peaks 1-3


Sunday, April 03 | 8:00PM - 11:00PM
Cash Bar
Room: Peaks 1-3


Monday, April 04 | 10:26AM - 10:26AM
Departure


*Session Chair.