Web Desc
Chromatin Modification Pathways
Organizer(s): Tony Kouzarides and Shelley L. Berger
Date: March 31 - April 05, 2005
Location: Snowbird Resort, Snowbird, UT, USA
Sponsored by Novartis Institutes for BioMedical Research and The Director's Fund
Summary of Meeting:
It has become apparent over the last few years that histone modifications mediate important biological functions. There is a plethora of these modifications and new ones are being discovered on a regular basis. These modifications are most commonly being studied in the context of transcriptional regulation, since classically modifications on histones were correlated with transcriptional state. However, it is now clear that any biological process involving DNA may be affected and regulated by histone modifications. As a result there are now indications that biological processes such as repair, replication and recombination are also under the control of histone modifications. Another recent development has been the mechanistic link between histone modifications and distinct processes involving nucleic acids such as DNA methylation and RNA interference. Each of these processes are under scrutiny in their own right, but the recent data suggests that each of these is intimately linked with histone modifications in the formation of heterochromatin structures which regulate transcription. Finally, data is now amassing that histone-modifying enzymes are linked to cancer. Inhibitors of deacetylases are now in phase I and II clinical trials and modifying enzymes are found over expressed, mutated and rearranged in cancer cells. The potential of these enzymes for radional drug discovery is therefore only now beginning to be realized. The aim of this meeting is to focus on basic research involving the normal biological functions relating to histone modifications and to highlight the pathways and enzymes that are deregulated in cancer cells.
Discounted Abstract Deadline: November 30 2004
Discounted Registration Deadline: January 31 2005
We gratefully acknowledge additional support for this conference from:
Novartis Institutes for BioMedical Research
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Merck Research Laboratories

Sangamo BioSciences, Inc.
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Thursday, March 31 | 3:00PM - 7:30PM
Registration
Room: Ballroom Lobby


Thursday, March 31 | 6:30PM - 7:30PM
Refreshments
Room: Ballroom Mezzanine & Lobby


Thursday, March 31 | 7:30PM - 8:30PM
Keynote Address
Room: Ballroom 2-3

Speaker 1 of 1
Richard A. Young, Whitehead Institute for Biomedical Research, USA
Genome Regulatory Networks in Living Cells

Friday, April 01 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles Nest


Friday, April 01 | 8:00AM - 11:00AM
Histone and Factor Acetylation
Room: Ballroom 2-3

Speaker 1 of 6
* Mary Ann Osley, University of New Mexico School of Medicine, USA

Friday, April 01 | 8:00AM - 11:00AM
Histone and Factor Acetylation
Room: Ballroom 2-3

Speaker 2 of 6
Michael Grunstein, University of California, Los Angeles, USA
Acetylation on the Histone Globular Core Regulates Gene Activity

Friday, April 01 | 8:00AM - 11:00AM
Histone and Factor Acetylation
Room: Ballroom 2-3

Speaker 3 of 6
Lorraine Pillus, University of California, San Diego, USA
Essential Functions for Chromatin Modifications

Friday, April 01 | 8:00AM - 11:00AM
Histone and Factor Acetylation
Room: Ballroom 2-3

Speaker 4 of 6
Sharon Y.R. Dent, University of Texas MD Anderson Cancer Center, USA
New Functions for Histone Modifying Activities

Friday, April 01 | 8:00AM - 11:00AM
Histone and Factor Acetylation
Room: Ballroom 2-3

Speaker 5 of 6
Melanie M. Ott, Gladstone Institutes, USA
The “Yin and Yin” of HIV Tat Acetylation and Deacetylation

Friday, April 01 | 8:00AM - 11:00AM
Histone and Factor Acetylation
Room: Ballroom 2-3

Speaker 6 of 6
W. Lee Kraus, University of Texas Southwestern Medical Center, USA
Short Talk: Reversible NAD+-Dependent Modulation of Chromatin Structure and Transcription by Poly(ADP-ribose) Polymerase-1 (PARP-1)

Friday, April 01 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine & Lobby


Friday, April 01 | 11:00AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Maybird


Friday, April 01 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Maybird


Friday, April 01 | 2:30PM - 4:30PM
Workshop 1

Speaker 1 of 10
* Ramin Shiekhattar, University of Miami, USA

Friday, April 01 | 2:30PM - 4:30PM
Workshop 1

Speaker 2 of 10
Ji-Joon Song, Korea Advanced Institute of Science and Technology, South Korea
Argonautica: Sclicer Revealed

Friday, April 01 | 2:30PM - 4:30PM
Workshop 1

Speaker 3 of 10
Vincent Géli, Centre National de la Recherche Scientifique, France
Structure and Functional Characterization of the RNA Recognition Motif of the Histone H3 Lysine Methyltransferase Set1

Friday, April 01 | 2:30PM - 4:30PM
Workshop 1

Speaker 4 of 10
Nevan J. Krogan, University of California, San Francisco, USA
Protein Complexes and Functional Pathways in Chromatin Metabolism

Friday, April 01 | 2:30PM - 4:30PM
Workshop 1

Speaker 5 of 10
Ann Dean, NIDDK, National Institutes of Health, USA
Histone Modifications in Enhancer Activation and Enhancer Blocking

Friday, April 01 | 2:30PM - 4:30PM
Workshop 1

Speaker 6 of 10
Xuetong Shen, University of Texas MD Anderson Cancer Center, USA
INO80 and gamma-H2AX Interaction Links ATP-dependent Chromatin Remodeling to DNA Damage Repair

Friday, April 01 | 2:30PM - 4:30PM
Workshop 1

Speaker 7 of 10
Claudius Vincenz, University of Michigan, USA
Visualization of the Histon Code in Cells

Friday, April 01 | 2:30PM - 4:30PM
Workshop 1

Speaker 8 of 10
Takashi Ito, Nagasaki University School of Medicine, Japan
Nucleosomal Histone Kinase-1 Phosphorylates H2A Thr 119 During Mitosis in the Early Drosophila Embryo

Friday, April 01 | 2:30PM - 4:30PM
Workshop 1

Speaker 9 of 10
Raymond C. Trievel, University of Michigan, USA
Analysis of the Substrate Specificity of a Protein Lysine Methyltransferase

Friday, April 01 | 2:30PM - 4:30PM
Workshop 1

Speaker 10 of 10
Raymond C. Trievel, University of Michigan, USA
Structural Basis of Substrate Recognition by SET Domain Methyltransferase

Friday, April 01 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Ballroom Mezzanine & Lobby


Friday, April 01 | 5:00PM - 7:00PM
Histone Ubiquitination
Room: Ballroom 2-3

Speaker 1 of 5
* Bradley R. Cairns, HHMI/University of Utah, USA

Friday, April 01 | 5:00PM - 7:00PM
Histone Ubiquitination
Room: Ballroom 2-3

Speaker 2 of 5
Shelley L. Berger, University of Pennsylvania, USA
Histone Ubiquitylation/Deupbiquitylation and Sumoylation Genomic Regulation

Friday, April 01 | 5:00PM - 7:00PM
Histone Ubiquitination
Room: Ballroom 2-3

Speaker 3 of 5
Mary Ann Osley, University of New Mexico School of Medicine, USA
H2B Ubuquitylation is Associated with Transcription Elongation

Friday, April 01 | 5:00PM - 7:00PM
Histone Ubiquitination
Room: Ballroom 2-3

Speaker 4 of 5
Ali Shilatifard, Northwestern University, USA
Yeast COMPASS Points the Way to Human MLL and its Role in Pathogens of Leukemia

Friday, April 01 | 5:00PM - 7:00PM
Histone Ubiquitination
Room: Ballroom 2-3

Speaker 5 of 5
Jaehoon Kim, Korea Advanced Institute of Science and Technology, South Korea
Short Talk: Human Homologue of Yeast BRE1 has Coactivator Function in Activator-Dependent Transcription

Friday, April 01 | 7:00PM - 8:00PM
Social Hour
Room: Superior/Superior Lobby/Maybird


Friday, April 01 | 7:30PM - 10:00PM
Poster Session 1
Room: Superior/Superior Lobby/Maybird


Saturday, April 02 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles Nest


Saturday, April 02 | 8:00AM - 11:00AM
Histone Methylation
Room: Ballroom 2-3

Speaker 1 of 6
* Ali Shilatifard, Northwestern University, USA

Saturday, April 02 | 8:00AM - 11:00AM
Histone Methylation
Room: Ballroom 2-3

Speaker 2 of 6
C. David Allis, Rockefeller University, USA
Beyond the Double Helix: Writing and Reading the ‘Histone Code’

Saturday, April 02 | 8:00AM - 11:00AM
Histone Methylation
Room: Ballroom 2-3

Speaker 3 of 6
Tony Kouzarides, University of Cambridge, UK
Histone Methylation and Back

Saturday, April 02 | 8:00AM - 11:00AM
Histone Methylation
Room: Ballroom 2-3

Speaker 4 of 6
Yi Zhang, HHMI/Harvard Medical School, Children's Hospital Boston, USA
Dissecting the Junction of Histone Methylation

Saturday, April 02 | 8:00AM - 11:00AM
Histone Methylation
Room: Ballroom 2-3

Speaker 5 of 6
Yang Shi, Children's Hospital Boston, Harvard Medical School, USA
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1



Saturday, April 02 | 8:00AM - 11:00AM
Histone Methylation
Room: Ballroom 2-3

Speaker 6 of 6
David Y. Lee, University of New Mexico Cancer Center, USA
Short Talk: Identification and Characterization of a Coactivator Protein which Binds to Arginine-Methylated Histone H3

Saturday, April 02 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine & Lobby


Saturday, April 02 | 11:00AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Maybird


Saturday, April 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Maybird


Saturday, April 02 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Ballroom Mezzanine & Lobby


Saturday, April 02 | 5:00PM - 7:00PM
Recruitment of Enzyme Complexes
Room: Ballroom 2-3

Speaker 1 of 5
* Robert E. Kingston, Massachusetts General Hospital, USA

Saturday, April 02 | 5:00PM - 7:00PM
Recruitment of Enzyme Complexes
Room: Ballroom 2-3

Speaker 2 of 5
Ramin Shiekhattar, University of Miami, USA
The histone demethylase complexes and their role in gene expression and cell fate

Saturday, April 02 | 5:00PM - 7:00PM
Recruitment of Enzyme Complexes
Room: Ballroom 2-3

Speaker 3 of 5
Geneviève Almouzni, Centre National de la Recherche Scientifique, France
Chromatin in Assembly Factors and Maintanance of Genome Organization

Saturday, April 02 | 5:00PM - 7:00PM
Recruitment of Enzyme Complexes
Room: Ballroom 2-3

Speaker 4 of 5
Danny F. Reinberg, HHMI/New York University, USA
Regulation of mRNA Biogenesis by the Coordinator Complex, which Binds to Methylated Lysine-4 of Histone H3

Saturday, April 02 | 5:00PM - 7:00PM
Recruitment of Enzyme Complexes
Room: Ballroom 2-3

Speaker 5 of 5
Yannick Doyon, Laval University, Canada
Short Talk: A Central Role for the Inhibitor of Growth Tumor Suppressor Family in Chromatin Modifying Complexes

Saturday, April 02 | 7:00PM - 8:00PM
Social Hour
Room: Superior/Superior Lobby/Maybird


Saturday, April 02 | 7:30PM - 10:00PM
Poster Session 2
Room: Superior/Superior Lobby/Maybird


Sunday, April 03 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles Nest


Sunday, April 03 | 8:00AM - 11:00AM
ATP-Dependent Chromatin Remodeling
Room: Ballroom 2-3

Speaker 1 of 6
* Sharon Y.R. Dent, University of Texas MD Anderson Cancer Center, USA

Sunday, April 03 | 8:00AM - 11:00AM
ATP-Dependent Chromatin Remodeling
Room: Ballroom 2-3

Speaker 2 of 6
Toshio Tsukiyama, Fred Hutchinson Cancer Research Center, USA
Mechanism of Chramatin Interaction by Isw2 Complex in vivo

Sunday, April 03 | 8:00AM - 11:00AM
ATP-Dependent Chromatin Remodeling
Room: Ballroom 2-3

Speaker 3 of 6
Jane Mellor, University of Oxford, UK
Isw1 ATPases in Transcription Elongation

Sunday, April 03 | 8:00AM - 11:00AM
ATP-Dependent Chromatin Remodeling
Room: Ballroom 2-3

Speaker 4 of 6
Bradley R. Cairns, HHMI/University of Utah, USA
Chromatin Remodeling Involves Directional DNA Translocation from an Internal Nucleosomal Site

Sunday, April 03 | 8:00AM - 11:00AM
ATP-Dependent Chromatin Remodeling
Room: Ballroom 2-3

Speaker 5 of 6
Robert E. Kingston, Massachusetts General Hospital, USA
Different Ways to Remodel Chromatin in an 'Altered Function' APT-Dependent Remodeler

Sunday, April 03 | 8:00AM - 11:00AM
ATP-Dependent Chromatin Remodeling
Room: Ballroom 2-3

Speaker 6 of 6
Blaine Bartholomew, University of Texas MD Anderson Cancer Center, USA
Short Talk: ATP-Dependent Nucleosome Mobilization Initiates Deep Within the Nucleosome

Sunday, April 03 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine & Lobby


Sunday, April 03 | 11:00AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Maybird


Sunday, April 03 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Maybird


Sunday, April 03 | 2:30PM - 4:30PM
Workshop 2

Speaker 1 of 9
* Fyodor D. Urnov, University of California, Berkeley, USA

Sunday, April 03 | 2:30PM - 4:30PM
Workshop 2

Speaker 2 of 9
Keiko Ozato, NICHD, National Institutes of Health, USA
Mammalian Double Bromodomain Protein Brd4 Recognizes Acetylated Histone Codes and Remains on Chromatin during Mitosis

Sunday, April 03 | 2:30PM - 4:30PM
Workshop 2

Speaker 3 of 9
Catharine L. Smith, University of Arizona, USA
Regulation of Histone H3 Phosphorylation and Cell Cycle Depression through a Novel CAMP Signaling Pathway

Sunday, April 03 | 2:30PM - 4:30PM
Workshop 2

Speaker 4 of 9
Nick Barlev, NEMC-Tufts School of Medicine, USA
Regulation of p53 by Methyltransferase Set7/9

Sunday, April 03 | 2:30PM - 4:30PM
Workshop 2

Speaker 5 of 9
Hinrich Gronemeyer, Institut de Génétique et de Biologie Molécullaire et Cellulaire, Strasbourg, France
Epigenetic Modulation of Tumor-Selective Death Signaling

Sunday, April 03 | 2:30PM - 4:30PM
Workshop 2

Speaker 6 of 9
Keji Zhao, NHLBI, National Institutes of Health, USA
Acetylation Islands Revealed Genome-wide Mapping Are Functional Regulatory Elements

Sunday, April 03 | 2:30PM - 4:30PM
Workshop 2

Speaker 7 of 9
Masami Horikoshi, University of Tokyo, Japan
Toward Elucidating the Mechanism of DNA Mediated Reactions

Sunday, April 03 | 2:30PM - 4:30PM
Workshop 2

Speaker 8 of 9
Brent Brower-Toland, Monsanto Company, USA
Participation of RNA Interference in the Formation of Heterochromatin in Drosophila

Sunday, April 03 | 2:30PM - 4:30PM
Workshop 2

Speaker 9 of 9
André Verdel, Harvard Medical School, USA
Two RNAi Complexes Required for Heterochromatin Assembly, RITS and RDRC, Interact and are Recruited to Centromeric RNAs

Sunday, April 03 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Ballroom Mezzanine & Lobby


Sunday, April 03 | 5:00PM - 7:00PM
Epigenetic Modifications and RNAi
Room: Ballroom 2-3

Speaker 1 of 5
* Geneviève Almouzni, Centre National de la Recherche Scientifique, France

Sunday, April 03 | 5:00PM - 7:00PM
Epigenetic Modifications and RNAi
Room: Ballroom 2-3

Speaker 2 of 5
Thomas Jenuwein, Max Planck Institute of Immunobiology and Epigenetics, Germany
The Epigenome in the Context of the Post-Genomic Era

Sunday, April 03 | 5:00PM - 7:00PM
Epigenetic Modifications and RNAi
Room: Ballroom 2-3

Speaker 3 of 5
Shiv I. S. Grewal, NCI, National Institutes of Health, USA
Role of RNAi Machinery in Heterochromatin Assembly

Sunday, April 03 | 5:00PM - 7:00PM
Epigenetic Modifications and RNAi
Room: Ballroom 2-3

Speaker 4 of 5
Robin C. Allshire, University of Edinburgh, UK
RNA Interference, Heterochromatin and Centromere Architecture

Sunday, April 03 | 5:00PM - 7:00PM
Epigenetic Modifications and RNAi
Room: Ballroom 2-3

Speaker 5 of 5
Neil Brockdorff, University of Oxford, UK
Short Talk: Function of Polycomb-Group Complex PRC1 in H2A Ubiquitylation and X Inactivation

Sunday, April 03 | 7:00PM - 8:00PM
Social Hour
Room: Superior/Superior Lobby/Maybird


Sunday, April 03 | 7:30PM - 10:00PM
Poster Session 3
Room: Superior/Superior Lobby/Maybird


Monday, April 04 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles Nest


Monday, April 04 | 8:00AM - 11:00AM
Chromatin in Transition: Histone Varients and Depletion
Room: Ballroom 2-3

Speaker 1 of 5
* Carl Wu, National Cancer Institute, NIH, USA
ATP-Dependent Chromatin Remodeling Complexes for Transcription

Monday, April 04 | 8:00AM - 11:00AM
Chromatin in Transition: Histone Varients and Depletion
Room: Ballroom 2-3

Speaker 2 of 5
Steven Henikoff, Fred Hutchinson Cancer Research Center, USA
Chromatin States Distinguished by Histone H3 Variants

Monday, April 04 | 8:00AM - 11:00AM
Chromatin in Transition: Histone Varients and Depletion
Room: Ballroom 2-3

Speaker 3 of 5
Jerry L. Workman, Stowers Institute for Medical Research, USA
Promotor and ORF Specific Rpd3 Complexes

Monday, April 04 | 8:00AM - 11:00AM
Chromatin in Transition: Histone Varients and Depletion
Room: Ballroom 2-3

Speaker 4 of 5
Hiten D. Madhani, University of California, San Francisco, USA
Control of Gene Silencing by Chromatin Modifications in Euchromatin

Monday, April 04 | 8:00AM - 11:00AM
Chromatin in Transition: Histone Varients and Depletion
Room: Ballroom 2-3

Speaker 5 of 5
Philippe E. Bouvet, Ecole Normale Superieure de Lyon, France
Short Talk: Structural and Functional Properties of macroH2A and H2ABbd Nucleosomes Variants

Monday, April 04 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine & Lobby


Monday, April 04 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Ballroom Mezzanine & Lobby


Monday, April 04 | 5:00PM - 7:00PM
Histone Modifications and Cancer
Room: Ballroom 2-3

Speaker 1 of 4
* Lorraine Pillus, University of California, San Diego, USA

Monday, April 04 | 5:00PM - 7:00PM
Histone Modifications and Cancer
Room: Ballroom 2-3

Speaker 2 of 4
Victoria M. Richon, Sanofi, USA
Development of SAHA for the Treatment of Cancer

Monday, April 04 | 5:00PM - 7:00PM
Histone Modifications and Cancer
Room: Ballroom 2-3

Speaker 3 of 4
Andreas J. Ledl, Germany
Short Talk: Viral Oncoproteins E1A and E7 and Cellular LxCxE Proteins Repress SUMO Modification of the Retinoblastoma Tumor Suppressor

Monday, April 04 | 5:00PM - 7:00PM
Histone Modifications and Cancer
Room: Ballroom 2-3

Speaker 4 of 4
Fyodor D. Urnov, University of California, Berkeley, USA
Reading and Writing the Epigenome: Chromatin as a Drug Target

Monday, April 04 | 8:00PM - 9:00PM
Social Hour
Room: Ballroom 2-3


Monday, April 04 | 8:00PM - 11:00PM
Entertainment
Room: Ballroom 2-3


Monday, April 04 | 8:00PM - 11:00PM
Cash Bar
Room: Ballroom 2-3


Tuesday, April 05 | 10:26AM - 10:26AM
Departure


*Session Chair.