Web Desc
Tuberculosis: Integrating Host and Pathogen Biology
Organizer(s): Gilla Kaplan, Clifton Barry III and Stewart Cole
Date: April 02 - 07, 2005
Location: Whistler Conference Centre, Whistler, BC, Canada
Part of the Global Health Series, Supported by the Bill & Melinda Gates Foundation
Summary of Meeting:
Tuberculosis is the leading infectious cause of mortality in the world today with 4 million deaths predicted for the year 2004. With the completion of the genome sequence of both Mycobacterium tuberculosis and Homo sapiens it is now possible to elucidate the dynamic interaction between the pathogen and its human host. Contemporary tools and novel technologies are currently being used to explore the molecular mechanisms that underlie host resistance and susceptibility, microbial drug resistance, the metabolic adaptations of the organism to latency and reactivation, and mechanisms of microbial pathogenesis. Recent studies have highlighted the importance of microbial regulatory systems and cell wall lipids in determining the ultimate outcome of infection. The development of novel vaccine candidates based on an understanding of the host response to infection has been facilitated by recent scientific advances. The aim of this meeting is to review the latest knowledge in these diverse fields of research and to provide an open forum for discussion and collaboration for scientists from the various disciplines required to control this disease.
Discounted Abstract Deadline: December 2 2004
Discounted Registration Deadline: February 2 2005
We gratefully acknowledge additional support for this conference from:
AstraZeneca R&DBill & Melinda Gates FoundationThe Ellison Medical Foundation
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Corixa Corporation
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Saturday, April 02 | 3:00PM - 7:30PM
Registration
Room: Grand Foyer


Saturday, April 02 | 6:30PM - 7:30PM
Refreshments
Room: Grand Foyer


Saturday, April 02 | 7:30PM - 8:30PM
Keynote Address
Room: Sea to Sky Ballrm A

Speaker 1 of 1
Paul W. Ewald, University of Louisville, USA
Vaccines and the Evolution of Virulence

Sunday, April 03 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky Ballrm B/C


Sunday, April 03 | 8:00AM - 11:00AM
Exploratory Genomics. Plenary Session sponsored by The Elli
son Medical Foundation

Room: Sea to Sky Ballrm A

Speaker 1 of 4
* Stewart T. Cole, Institut Pasteur, France
Evolutionary and Comparative Genomics of the M. tuberculosis Complex

Sunday, April 03 | 8:00AM - 11:00AM
Exploratory Genomics. Plenary Session sponsored by The Elli
son Medical Foundation

Room: Sea to Sky Ballrm A

Speaker 2 of 4
Gary K. Schoolnik, Stanford University, USA
The Transcriptome of M. tuberculosis: Lessons Learned from a Study of the DosR Regalon

Sunday, April 03 | 8:00AM - 11:00AM
Exploratory Genomics. Plenary Session sponsored by The Elli
son Medical Foundation

Room: Sea to Sky Ballrm A

Speaker 3 of 4
Eric J. Rubin, Harvard T.H. Chan School of Public Health, USA
Genetic and Proteomic Approaches to Virulence in Tuberculosis

Sunday, April 03 | 8:00AM - 11:00AM
Exploratory Genomics. Plenary Session sponsored by The Elli
son Medical Foundation

Room: Sea to Sky Ballrm A

Speaker 4 of 4
Rajesh S. Gokhale, National Institute of Immunology, India
How Metabolic Diversity may be Generated from Limited Number of Genes: Exploring the Architecture of Mycobacterial Cell Envelope

Sunday, April 03 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Sunday, April 03 | 11:00AM - 1:00PM
Poster Setup
Room: Sea to Sky Ballrm B/C


Sunday, April 03 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky Ballrm B/C


Sunday, April 03 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Grand Foyer


Sunday, April 03 | 5:00PM - 7:00PM
Mycobacterial Metabolism
Room: Sea to Sky Ballrm A

Speaker 1 of 4
* Douglas B. Young, Imperial College London, UK
and

Sunday, April 03 | 5:00PM - 7:00PM
Mycobacterial Metabolism
Room: Sea to Sky Ballrm A

Speaker 2 of 4
Brian D. Robertson, Imperial College London, UK
The Role of Trehalose in Mycobacterial Persistence

Sunday, April 03 | 5:00PM - 7:00PM
Mycobacterial Metabolism
Room: Sea to Sky Ballrm A

Speaker 3 of 4
David R. Sherman, University of Washington, USA
The Hypoxia/NO Stress Regulon

Sunday, April 03 | 5:00PM - 7:00PM
Mycobacterial Metabolism
Room: Sea to Sky Ballrm A

Speaker 4 of 4
Christophe Guilhot, Centre National de la Recherche Scientifique, France
Phenolic glycolipid biosynthesis

Sunday, April 03 | 7:00PM - 8:00PM
Social Hour
Room: Sea to Sky Ballrm B/C


Sunday, April 03 | 7:30PM - 10:00PM
Poster Session 1
Room: Sea to Sky Ballrm B/C


Monday, April 04 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky Ballrm B/C


Monday, April 04 | 8:00AM - 10:20AM
Mechanism of Drug Action
Room: Sea to Sky Ballrm A

Speaker 1 of 3
* Clifton E. Barry III, NIAID, National Institutes of Health, USA
The Role of Nitroimidazoles in Understanding Non-Replicating Persistence of MTB

Monday, April 04 | 8:00AM - 10:20AM
Mechanism of Drug Action
Room: Sea to Sky Ballrm A

Speaker 2 of 3
James C. Sacchettini, Texas A & M University, USA
Structural Biology on Drug Targets from M. tuberculosis

Monday, April 04 | 8:00AM - 10:20AM
Mechanism of Drug Action
Room: Sea to Sky Ballrm A

Speaker 3 of 3
Stephen H. Gillespie, Royal Free and University College London, UK
Developing Understanding of Anti-tuberculosis Chemotherapy through Monotherapy Studies



Monday, April 04 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Monday, April 04 | 10:20AM - 11:00AM
Host-Pathogen Interaction 1
Room: Sea to Sky Ballrm A

Speaker 1 of 1
Alan Aderem, Center for Infectious Disease Research, USA
Systems Biology and Immunity: A Systems Approach to Dissecting Immunity


Monday, April 04 | 11:00AM - 1:00PM
Poster Setup
Room: Sea to Sky Ballrm B/C


Monday, April 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky Ballrm B/C


Monday, April 04 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Grand Foyer


Monday, April 04 | 5:00PM - 7:00PM
Host-Pathogen Interaction 2
Room: Sea to Sky Ballrm A

Speaker 1 of 3
* Gilla Kaplan, University of Cape Town, South Africa
Differential Host Response to Clinical Isolates of M. tuberculosis

Monday, April 04 | 5:00PM - 7:00PM
Host-Pathogen Interaction 2
Room: Sea to Sky Ballrm A

Speaker 2 of 3
JoAnne L. Flynn, University of Pittsburgh School of Medicine, USA
Non-human Primates as a Model for Human Tuberculosis

Monday, April 04 | 5:00PM - 7:00PM
Host-Pathogen Interaction 2
Room: Sea to Sky Ballrm A

Speaker 3 of 3
Adrian V. S. Hill, Jenner Institute, University of Oxford, UK
Tuberculosis - Immunogenetics and Vaccine Design

Monday, April 04 | 7:00PM - 8:00PM
Social Hour
Room: Sea to Sky Ballrm B/C


Monday, April 04 | 7:30PM - 10:00PM
Poster Session 2
Room: Sea to Sky Ballrm B/C


Tuesday, April 05 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky Ballrm B/C


Tuesday, April 05 | 8:00AM - 11:00AM
Macrophage Biology
Room: Sea to Sky Ballrm A

Speaker 1 of 4
* David G. Russell, Cornell University, USA
Mycobacterium and the Macrophage: Who Says What to Whom?

Tuesday, April 05 | 8:00AM - 11:00AM
Macrophage Biology
Room: Sea to Sky Ballrm A

Speaker 2 of 4
David J. Kusner, University of Iowa, USA
Phagosome Maturation in Response to MTB Infection


Tuesday, April 05 | 8:00AM - 11:00AM
Macrophage Biology
Room: Sea to Sky Ballrm A

Speaker 3 of 4
Lalita Ramakrishnan, University of Cambridge, UK
Monitoring and modulating Mycobacterium-Macrophage Interactions in Real-Time in Transparent Zebrafish Embryos

Tuesday, April 05 | 8:00AM - 11:00AM
Macrophage Biology
Room: Sea to Sky Ballrm A

Speaker 4 of 4
Vojo Deretic, University of New Mexico Health Sciences Center, USA
Autophagy - Novel Innate Immunity Mechanism

Tuesday, April 05 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Tuesday, April 05 | 11:00AM - 1:00PM
Poster Setup
Room: Sea to Sky Ballrm B/C


Tuesday, April 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Sea to Sky Ballrm B/C


Tuesday, April 05 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Grand Foyer


Tuesday, April 05 | 5:00PM - 7:00PM
Genetic Determinants of Host Response
Room: Sea to Sky Ballrm A

Speaker 1 of 3
* Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany
Host Pathogen Interactions in Tuberculosis: From a Global to a Specific View

Tuesday, April 05 | 5:00PM - 7:00PM
Genetic Determinants of Host Response
Room: Sea to Sky Ballrm A

Speaker 2 of 3
Emil Skamene, McGill University Health Centre, Canada
Genetic Determinants of Resistance and Susceptibility


Tuesday, April 05 | 5:00PM - 7:00PM
Genetic Determinants of Host Response
Room: Sea to Sky Ballrm A

Speaker 3 of 3
Warwick J. Britton, Centenary Institute, Australia
Manipulating the Cytokine Environment to Enhance Responses to Vaccines against Tuberculosis.

Tuesday, April 05 | 7:00PM - 8:00PM
Social Hour
Room: Sea to Sky Ballrm B/C


Tuesday, April 05 | 7:30PM - 10:00PM
Poster Session 3
Room: Sea to Sky Ballrm B/C


Wednesday, April 06 | 7:00AM - 8:00AM
Breakfast
Room: Sea to Sky Ballrm B/C


Wednesday, April 06 | 8:00AM - 11:00AM
Vaccines and Immune Response
Room: Sea to Sky Ballrm A

Speaker 1 of 4
* Peter L. Andersen, Statens Serum Institut, Denmark
TB Subunit Vaccines - Recent Developments in the Post Antigen Discovery Era

Wednesday, April 06 | 8:00AM - 11:00AM
Vaccines and Immune Response
Room: Sea to Sky Ballrm A

Speaker 2 of 4
Robert J. North, Trudeau Institute, USA
Mouse Tuberculous as a Model of Tuberculosis in Susceptible Humans

Wednesday, April 06 | 8:00AM - 11:00AM
Vaccines and Immune Response
Room: Sea to Sky Ballrm A

Speaker 3 of 4
Mark Raymond Alderson, PATH, USA
Development of a Subunit Vaccine for Tuberculosis: Rational Selection of Antigens and Adjuvants

Wednesday, April 06 | 8:00AM - 11:00AM
Vaccines and Immune Response
Room: Sea to Sky Ballrm A

Speaker 4 of 4
Willem A. Hanekom, Bill & Melinda Gates Foundation, USA
The Host Immune Response to BCG Vaccination

Wednesday, April 06 | 9:20AM - 9:40AM
Coffee Break
Room: Grand Foyer


Wednesday, April 06 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Grand Foyer


Wednesday, April 06 | 5:00PM - 7:00PM
Bacterial Signaling and Defense Mechanisms
Room: Sea to Sky Ballrm A

Speaker 1 of 3
* Carl F. Nathan, Weill Cornell Medical College, USA
New Targets In M. Tuberculosis: Stress Resistance and Repair

Wednesday, April 06 | 5:00PM - 7:00PM
Bacterial Signaling and Defense Mechanisms
Room: Sea to Sky Ballrm A

Speaker 2 of 3
Valerie Mizrahi, University of Cape Town, South Africa
The Role of Error-Prone DNA Polymerases in Damage Tolerance and Genetic Adaptation in Mycobacteria

Wednesday, April 06 | 5:00PM - 7:00PM
Bacterial Signaling and Defense Mechanisms
Room: Sea to Sky Ballrm A

Speaker 3 of 3
William R. Bishai, Johns Hopkins School of Medicine and K-RITH, USA
Mycobacterial Stress Response Systems and Animal Models

Wednesday, April 06 | 7:00PM - 8:00PM
Social Hour
Room: Sea to Sky Ballrm B/C


Wednesday, April 06 | 8:00PM - 11:00PM
Entertainment
Room: Sea to Sky Ballrm B/C


Wednesday, April 06 | 8:00PM - 11:00PM
Cash Bar
Room: Sea to Sky Ballrm B/C


Thursday, April 07 | 10:26AM - 10:26AM
Departure


*Session Chair.