Web Desc
Molecular Biology of Cardiac Diseases and Regeneration
Organizer(s): Elizabeth McNally and Jonathan A. Epstein
Date: April 03 - 08, 2005
Location: Sheraton Steamboat Resort, Steamboat Springs, CO, USA
Supported by The Director's Fund
Summary of Meeting:
Cardiovascular disease is the leading cause of morbidity and mortality in the United States. Myocardial infarction and congestive heart failure, together, account for the majority of cardiovascular disease. An underlying theme in both myocardial infarction and congestive heart failure is an insufficient number of properly functioning cardiomyocytes. Repairing defective cardiomyocytes and/or regenerating cardiomyocytes are important experimental means to improve heart function. To this end, stem cells from embryonic and adult sources have been increasingly explored as a means of restoring cardiac function. Vascular growth remains a significant concern since vascular supply is essential to the survival of regenerated cardiomyocytes. To establish a fully functioning cardiomyocyte requires a detailed understanding of cardiomyocyte differentiation as well as a pluripotent stem cell capable of achieving the cardiomyocyte developmental pathway. At the cellular level, cardiomyocyte dysfunction arises from ischemic insult, genetic or toxic metabolic defects. The broad etiology responsible for the dysfunctioning cardiomyocyte has not limited the identification of molecular pathways in common to these many different forms of heart failure. Defects of intracellular calcium homeostasis are a frequent issue in failing cardiomyocytes. Perturbations of calcium homeostasis directly affect sarcomere function and simultaneously render an altered signaling cascade. The goal of this meeting is twofold. We will discuss cellular and molecular pathways necessary for cardiac regeneration. This will include a discussion of stem cell choice as well as a full evaluation of current stem cell transplant programs with an emphasis on full integration and differentiation of the transplanted stem cell. The second major emphasis of the meeting will be to discuss the failing cardiomyocyte focused on the common and critical molecular pathways found in the diseased cardiomyocyte. These two broad areas overlap considerably since both approaches will be required to successfully repair a failed cardiomyocyte.
Discounted Abstract Deadline: December 2 2004
Discounted Registration Deadline: February 3 2005
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Osiris Therapeutics, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13-HL079688-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Sunday, April 03 | 3:00PM - 7:30PM
Registration
Room: Foyer


Sunday, April 03 | 6:30PM - 7:30PM
Refreshments
Room: Foyer


Sunday, April 03 | 7:30PM - 8:30PM
Keynote Address
Room: Storm Peak/Mt Werner

Speaker 1 of 1
Mark T. Keating, Novartis Institutes for BioMedical Research, USA
Cardiac Regeneration

Monday, April 04 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Sevens


Monday, April 04 | 8:00AM - 11:15AM
Cardiovascular Development I
Room: Storm Peak/Mt Werner

Speaker 1 of 6
* Jonathan A. Epstein, University of Pennsylvania, USA
Develpment of the Cardiac Outflow Tract

Monday, April 04 | 8:00AM - 11:15AM
Cardiovascular Development I
Room: Storm Peak/Mt Werner

Speaker 2 of 6
Didier Stainier, Max Planck Institute for Heart and Lung Research, Germany
Zebrafish Models of Heart Development


Monday, April 04 | 8:00AM - 11:15AM
Cardiovascular Development I
Room: Storm Peak/Mt Werner

Speaker 3 of 6
Deepak Srivastava, Gladstone Institutes, USA
Cardiac Developmental Genes: Implications for Childhood and Adult Disease

Monday, April 04 | 8:00AM - 11:15AM
Cardiovascular Development I
Room: Storm Peak/Mt Werner

Speaker 4 of 6
Eric N. Olson, University of Texas Southwestern Medical Center, USA
Control of Heart Development by Transcriptional Coactivators and Corepressors

Monday, April 04 | 8:00AM - 11:15AM
Cardiovascular Development I
Room: Storm Peak/Mt Werner

Speaker 5 of 6
Edward E. Morrisey, University of Pennsylvania, USA
Short Talk: A Unique Role for Foxp4 in Late Cardiac Development

Monday, April 04 | 8:00AM - 11:15AM
Cardiovascular Development I
Room: Storm Peak/Mt Werner

Speaker 6 of 6
Kory J. Lavine, Washington University School of Medicine, USA
Short Talk: Fibroblast Growth Factor Signals Regulate Myocardial Proliferation and Coronary Vasculogenesis in vivo

Monday, April 04 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Monday, April 04 | 11:15AM - 1:00PM
Poster Setup
Room: Sunshine Peak


Monday, April 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunshine Peak


Monday, April 04 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Monday, April 04 | 5:00PM - 7:00PM
Cardiovascular Development II
Room: Storm Peak/Mt Werner

Speaker 1 of 4
Kenneth R. Chien, Karolinska Institutet, Sweden
The Islet-1+ Progenitor Story: Heart Cell Lineage Diversification in Develpment and Disease

Monday, April 04 | 5:00PM - 7:00PM
Cardiovascular Development II
Room: Storm Peak/Mt Werner

Speaker 2 of 4
* Peter F. Carmeliet, University of Leuven, VIB, Belgium
Mechanisms of Angiogenesis


Monday, April 04 | 5:00PM - 7:00PM
Cardiovascular Development II
Room: Storm Peak/Mt Werner

Speaker 3 of 4
David A. Cheresh, University of California, San Diego, USA
Growth Factor Signaling in the Tumor Endothelium, Limiting Ischemic Injury Following Myocardial Infarction

Monday, April 04 | 5:00PM - 7:00PM
Cardiovascular Development II
Room: Storm Peak/Mt Werner

Speaker 4 of 4
Eric C. Svensson, University of Chicago, USA
Short Talk: Fog Genes are Required for Cardiac Looping in Zebrafish

Monday, April 04 | 7:00PM - 8:00PM
Social Hour
Room: Foyer


Monday, April 04 | 7:30PM - 10:00PM
Poster Session 1
Room: Sunshine Peak


Tuesday, April 05 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Sevens


Tuesday, April 05 | 8:00AM - 11:00AM
Mechanisms of Cardiomyocyte Failure
Room: Storm Peak/Mt Werner

Speaker 1 of 6
Jonathan G. Seidman, Harvard Medical School, USA
Cardac Morhology, Fibrosis, and Arrhythmia in Hypertrophic and PRKAG2 Cardiomyopathy

Tuesday, April 05 | 8:00AM - 11:00AM
Mechanisms of Cardiomyocyte Failure
Room: Storm Peak/Mt Werner

Speaker 2 of 6
* Elizabeth M. McNally, Northwestern University, USA
Cytoskeletal Defects in Cardiomyopathy

Tuesday, April 05 | 8:00AM - 11:00AM
Mechanisms of Cardiomyocyte Failure
Room: Storm Peak/Mt Werner

Speaker 3 of 6
Guido E. Tarone, Universita di Torino, Italy
Short Talk: Melusin, a Muscle Specific Integrin Binding Protein, Protects from Cardiac Dilation in Response to Pressure Overload

Tuesday, April 05 | 8:00AM - 11:00AM
Mechanisms of Cardiomyocyte Failure
Room: Storm Peak/Mt Werner

Speaker 4 of 6
Joseph M. Metzger, University of Minnesota Medical School, USA
Short Talk: Rescue of Dystrophic Cardiomyopathy Following Acute Administration of Polaxomer 188 in the mdx Mouse

Tuesday, April 05 | 8:00AM - 11:00AM
Mechanisms of Cardiomyocyte Failure
Room: Storm Peak/Mt Werner

Speaker 5 of 6
Jennifer L. Hall, University of Minnesota, USA
Short Talk: Identification and Regulation of Sprouty1, an Intrinsic Negative Inhibitor of the ERK Cascade, in the Human Heart

Tuesday, April 05 | 8:00AM - 11:00AM
Mechanisms of Cardiomyocyte Failure
Room: Storm Peak/Mt Werner

Speaker 6 of 6
Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA
Short Talk: Cardiac Development and Aging in Drosophila

Tuesday, April 05 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Tuesday, April 05 | 11:00AM - 1:00PM
Poster Setup
Room: Sunshine Peak


Tuesday, April 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunshine Peak


Tuesday, April 05 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Tuesday, April 05 | 5:00PM - 7:15PM
Stem Cells in Cardiac Regeneration
Room: Storm Peak/Mt Werner

Speaker 1 of 4
* Charles E. Murry, University of Washington, USA
Stem Cell Transplantation for Cardiac Repair

Tuesday, April 05 | 5:00PM - 7:15PM
Stem Cells in Cardiac Regeneration
Room: Storm Peak/Mt Werner

Speaker 2 of 4
Michael D. Schneider, Imperial College London, UK
Stem Cells in Cardiomyocyte Regeneration

Tuesday, April 05 | 5:00PM - 7:15PM
Stem Cells in Cardiac Regeneration
Room: Storm Peak/Mt Werner

Speaker 3 of 4
Benoit G. Bruneau, Gladstone Institutes, USA
The Homeodomain Transcription Factor Irx5 Establishes the Mouse Cardiac Ventricular Repolarization Gradient

Tuesday, April 05 | 5:00PM - 7:15PM
Stem Cells in Cardiac Regeneration
Room: Storm Peak/Mt Werner

Speaker 4 of 4
Nadia A. Rosenthal, The Jackson Laboratory, USA
Enhancing Cardiac Regeneration with Growth Factors

Tuesday, April 05 | 7:15PM - 8:15PM
Social Hour
Room: Foyer


Tuesday, April 05 | 7:30PM - 10:00PM
Poster Session 2
Room: Sunshine Peak


Wednesday, April 06 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Sevens


Wednesday, April 06 | 8:00AM - 11:15AM
Molecular Pathogenesis of Heart Failure
Room: Storm Peak/Mt Werner

Speaker 1 of 6
Andre Terzic, Mayo Clinic College of Medicine, USA
KATP Channels in Stress Response

Wednesday, April 06 | 8:00AM - 11:15AM
Molecular Pathogenesis of Heart Failure
Room: Storm Peak/Mt Werner

Speaker 2 of 6
Andrew R. Marks, Columbia University College of Physicians and Surgeons, USA
Molecular Basis of Heart Failure and Cardiac Arrhythmias and Novel Therapy

Wednesday, April 06 | 8:00AM - 11:15AM
Molecular Pathogenesis of Heart Failure
Room: Storm Peak/Mt Werner

Speaker 3 of 6
* R. John Solaro, University of Illinois at Chicago, USA
Thin Filament Defects in the Failing Heart.

Wednesday, April 06 | 8:00AM - 11:15AM
Molecular Pathogenesis of Heart Failure
Room: Storm Peak/Mt Werner

Speaker 4 of 6
Anthony J. Muslin, Tectonic Therapeutic, Inc., USA
Short Talk: Akt1 Promotes Physiologic, but Antagonizes Pathologic, Cardiac Growth

Wednesday, April 06 | 8:00AM - 11:15AM
Molecular Pathogenesis of Heart Failure
Room: Storm Peak/Mt Werner

Speaker 5 of 6
Kenneth Walsh, University of Virginia School of Medicine, USA
Short Talk: Disruption of Coordinated Tissue Growth and Angiogenesis in the Heart Mediates Progression from Adaptive Cardiac Hypertrophy to Heart Failure

Wednesday, April 06 | 8:00AM - 11:15AM
Molecular Pathogenesis of Heart Failure
Room: Storm Peak/Mt Werner

Speaker 6 of 6
Pilar Ruiz-Lozano, Stanford University, USA
Short Talk: Migratory Precursors and Myocyte Function


Wednesday, April 06 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, April 06 | 11:00AM - 1:00PM
Poster Setup
Room: Sunshine Peak


Wednesday, April 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunshine Peak


Wednesday, April 06 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Wednesday, April 06 | 5:00PM - 7:00PM
Signaling Defects in Cardiomyocyte Failure
Room: Storm Peak/Mt Werner

Speaker 1 of 4
* Jean E. Schaffer, Joslin Diabetes Center, Harvard Medical School, USA
Lipid Metabolic Defects as a Cause of Cardiomyopathy

Wednesday, April 06 | 5:00PM - 7:00PM
Signaling Defects in Cardiomyocyte Failure
Room: Storm Peak/Mt Werner

Speaker 2 of 4
Jeffery D. Molkentin, Cincinnati Children's Hospital Medical Center, USA
Analysis of Cyclophilin D Function Reveals a Necessary Role for Mitochondrial Pore Permeability

Wednesday, April 06 | 5:00PM - 7:00PM
Signaling Defects in Cardiomyocyte Failure
Room: Storm Peak/Mt Werner

Speaker 3 of 4
Howard A. Rockman, Duke University Medical Center, USA
New Concepts in Heptahelical Receptor Signaling in Heart Failure

Wednesday, April 06 | 5:00PM - 7:00PM
Signaling Defects in Cardiomyocyte Failure
Room: Storm Peak/Mt Werner

Speaker 4 of 4
Richard T. Lee, Harvard University, USA
Short Talk: Injectable Self-Assembling Nanofibers for Targeted Myocardial Delivery

Wednesday, April 06 | 7:00PM - 8:00PM
Social Hour
Room: Foyer


Wednesday, April 06 | 7:30PM - 10:00PM
Poster Session 3
Room: Sunshine Peak


Thursday, April 07 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles/Sevens


Thursday, April 07 | 8:00AM - 11:15AM
Cell Death and Mitochondrial Function
Room: Storm Peak/Mt Werner

Speaker 1 of 6
* Michael T. Crow, Johns Hopkins School of Medicine, USA
Control of Mitochaondrial Death Signaling in the Heart by ARC

Thursday, April 07 | 8:00AM - 11:15AM
Cell Death and Mitochondrial Function
Room: Storm Peak/Mt Werner

Speaker 2 of 6
* Eduardo Marban, Cedars-Sinai Medical Center, USA
Cardiac Stem Cells

Thursday, April 07 | 8:00AM - 11:15AM
Cell Death and Mitochondrial Function
Room: Storm Peak/Mt Werner

Speaker 3 of 6
Peter J. Gruber, University of Iowa, USA
Short Talk: Epigenetic Modifications Reduce the Severity of Ischemia-Reperfusion Injury in the Murine Heart

Thursday, April 07 | 8:00AM - 11:15AM
Cell Death and Mitochondrial Function
Room: Storm Peak/Mt Werner

Speaker 4 of 6
Michael Seth Kapiloff, Oregon Health & Science University, USA
Short Talk: The mAKAP Signaling Complex and the Induction of Cardiac Myocyte Hypertrophy

Thursday, April 07 | 8:00AM - 11:15AM
Cell Death and Mitochondrial Function
Room: Storm Peak/Mt Werner

Speaker 5 of 6
April Stempien-Otero, University of Washington, USA
Short Talk: Plasminogen Dependent Cardiac Fibrosis

Thursday, April 07 | 8:00AM - 11:15AM
Cell Death and Mitochondrial Function
Room: Storm Peak/Mt Werner

Speaker 6 of 6
Sameer S. Chopra, Vanderbilt University School of Medicine, USA
Short Talk: The Voltage-Gated Sodium Channel SCN5A is Required for Embryonic Heart Development and Function in Zebrafish

Thursday, April 07 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, April 07 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Foyer


Thursday, April 07 | 5:00PM - 7:00PM
Stem Cell Diversity
Room: Storm Peak/Mt Werner

Speaker 1 of 4
Mark F. Pittenger, University of Maryland Medical Center, USA
Allogenetic Mesemchymal Stem Cells in Cardiac Therapeutics

Thursday, April 07 | 5:00PM - 7:00PM
Stem Cell Diversity
Room: Storm Peak/Mt Werner

Speaker 2 of 4
* Doris A. Taylor, Texas Heart Institute, USA
Short Talk: Putting Vascular Back into Stem Cell based Cardiovascular Repair

Thursday, April 07 | 5:00PM - 7:00PM
Stem Cell Diversity
Room: Storm Peak/Mt Werner

Speaker 3 of 4
Cindy M. Martin, University of Minnesota, USA
Short Talk: Progenitor Cell Populations and their Participation in Myocardial Regeneration

Thursday, April 07 | 5:00PM - 7:00PM
Stem Cell Diversity
Room: Storm Peak/Mt Werner

Speaker 4 of 4
Michel Pucéat, INSERM, France
Short Talk: Stem Cells Improves Left Ventricular Function in Infarcted Sheep Myocardium

Thursday, April 07 | 7:00PM - 8:00PM
Social Hour
Room: Foyer


Thursday, April 07 | 8:00PM - 11:00PM
Entertainment
Room: Storm Peak/Mt Werner


Thursday, April 07 | 8:00PM - 11:00PM
Cash Bar
Room: Storm Peak/Mt Werner


Friday, April 08 | 10:26AM - 10:26AM
Departure


*Session Chair.