Web Desc
Molecular Mechanisms of Transmissible Spongiform Encephalopathies (Prion Diseases)
joint with Central Nervous System Inflammation: Mechanisms, Consequences and Therapeutic Strategies
Organizer(s): Adriano M. Aguzzi and Markus Glatzel
Date: January 11 - 15, 2005
Location: Snowbird Resort, Snowbird, UT, USA
Supported by The Director's Fund
Summary of Meeting:
Transmissible Spongiform Encephalopathies have been known to exist for centuries, and have received a great deal of attention in the last decade on account of the outbreaks of the Bovine Spongiform Encephalopathy and the Chronic Wasting Disease epidemics. Studies with genetically modified mice have established several fundamental principles of prion diseases, such as the absolute necessity of the prion protein for its pathogenesis. Recent advances in the structural biology of prion proteins, in concert with functional studies have helped to shed light on possible normal and disease associated roles of the prion protein. This has opened the possibility to study therapeutical principles in prion diseases. However, essential questions such as the true nature of the infectious agent, and the detailed molecular mechanisms of prion diseases await elucidation. The goal of the meeting is to bring together leading experts from different fields of prion disease research in order to discuss recent advances, and in order to devise new approaches on solving problems posed by these enigmatic diseases.
Discounted Abstract Deadline: September 17 2004
Discounted Registration Deadline: November 11 2004
We gratefully acknowledge additional support for this conference from:
Beckman Coulter Foundation, Inc.Cattleman
We gratefully acknowledge the generous grant for this conference provided by:

National Institute on Aging (NIA)
Grant No. 1R13-AG025624-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, January 11 | 3:00PM - 7:30PM
Registration
Room: Ballroom Lobby


Tuesday, January 11 | 6:30PM - 7:30PM
Refreshments
Room: Ballroom Mezzanine & Lobby


Tuesday, January 11 | 7:30PM - 8:30PM
Keynote Address
Room: Ballroom 3

Speaker 1 of 1
Bruce W. Chesebro, Rocky Mountain Laboratories, NIAID, National Institutes of Health, USA
Direct and Indirect Mechanisms of Pathogenesis in TSE Diseases

Wednesday, January 12 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Superior Lobby


Wednesday, January 12 | 8:00AM - 11:00AM
TSE in Humans and Animals
Room: Ballroom 3

Speaker 1 of 6
* Jean C. Manson, Institute for Animal Health, Edinburgh, UK

Wednesday, January 12 | 8:00AM - 11:00AM
TSE in Humans and Animals
Room: Ballroom 3

Speaker 2 of 6
Gino Miele, University Hospital of Zürich, Switzerland
Transcription Profiling of Prion Diseases

Wednesday, January 12 | 8:00AM - 11:00AM
TSE in Humans and Animals
Room: Ballroom 3

Speaker 3 of 6
Markus Glatzel, Hamburg University, Germany
Peripheral Pathogenesis of Human Prion Diseases

Wednesday, January 12 | 8:00AM - 11:00AM
TSE in Humans and Animals
Room: Ballroom 3

Speaker 4 of 6
Suzette A. Priola, Rocky Mountain Laboratories, NIAID, National Institutes of Health, USA
Acute versus Persistent PrP-res Formation during Establishment of a TSE Infection

Wednesday, January 12 | 8:00AM - 11:00AM
TSE in Humans and Animals
Room: Ballroom 3

Speaker 5 of 6
George A. Carlson, McLaughlin Research Institute, USA
Short Talk: Dissection of Genetic Susceptibility to Prion Disease In Vivo and In Vitro

Wednesday, January 12 | 8:00AM - 11:00AM
TSE in Humans and Animals
Room: Ballroom 3

Speaker 6 of 6
Richard S. Stewart, Washington University School of Medicine, USA
Short Talk: Neurodegenerative Illness Induced in Transgenic Mice by Transmembrane PrP is Dependent upon Expression of Endogenous PrP

Wednesday, January 12 | 8:00AM - 11:15AM
Molecular Effectors of CNS Inflammation
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 1 of 4
* Trevor Owens, University of Southern Denmark, Denmark
Immune-glial interactions in induction and regulation of CNS inflammation


Wednesday, January 12 | 8:00AM - 11:15AM
Molecular Effectors of CNS Inflammation
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 2 of 4
Iain L. Campbell, University of Sydney, Australia
Cytokine Signaling in CNS Inflammation and Disease


Wednesday, January 12 | 8:00AM - 11:15AM
Molecular Effectors of CNS Inflammation
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 3 of 4
Scott R. Barnum, University of Alabama, Birmingham, USA
Complement and Demyelinating Disease: Not as Simple as We Thought


Wednesday, January 12 | 8:00AM - 11:15AM
Molecular Effectors of CNS Inflammation
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 4 of 4
V. Wee Yong, University of Calgary, Canada
Matrix Metalloproteinases


Wednesday, January 12 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine & Lobby


Wednesday, January 12 | 11:00AM - 1:00PM
Poster Setup
Room: Wasatch/Superior/Superior Lobby


Wednesday, January 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Wasatch/Superior/Superior Lobby


Wednesday, January 12 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Ballroom Mezzanine & Lobby


Wednesday, January 12 | 5:00PM - 7:00PM
Structure and Propagation of Prion Proteins
Room: Ballroom 3

Speaker 1 of 4
* Susan Lindquist, HHMI/Whitehead Institute for Biomedical Research, USA
Prion Assembly and Disassembly

Wednesday, January 12 | 5:00PM - 7:00PM
Structure and Propagation of Prion Proteins
Room: Ballroom 3

Speaker 2 of 4
Byron Caughey, Rocky Mountain Laboratories, NIAID, National Institutes of Health, USA
Uptake and Neuritic Transport of PrP-res Coincident with Scrapie Infection of Neuronal Cells

Wednesday, January 12 | 5:00PM - 7:00PM
Structure and Propagation of Prion Proteins
Room: Ballroom 3

Speaker 3 of 4
Reed B. Wickner, National Institutes of Health, USA
The [URE3] Prion: Ure2p Prion Domain and Prion Generation

Wednesday, January 12 | 5:00PM - 7:00PM
Structure and Propagation of Prion Proteins
Room: Ballroom 3

Speaker 4 of 4
Ilia V. Baskakov, University of Maryland School of Medicine, USA
Short Talk: The First Synthetic Mammalian Prion

Wednesday, January 12 | 5:00PM - 7:15PM
Brain Entry of Cellular Effectors of CNS Inflammation
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 1 of 6
* Richard M. Ransohoff, Third Rock Ventures, USA
Chemokines


Wednesday, January 12 | 5:00PM - 7:15PM
Brain Entry of Cellular Effectors of CNS Inflammation
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 2 of 6
Britta Engelhardt, Theodor Kocher Institute/Universitat Bern, Switzerland
Molecular Steps involved in T lymphocyte migration across the blood-brain barrier


Wednesday, January 12 | 5:00PM - 7:15PM
Brain Entry of Cellular Effectors of CNS Inflammation
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 3 of 6
Francesca Aloisi, Instituto Superior de Sanita, Italy
Lymphod neogenesis in the inflamed CNS


Wednesday, January 12 | 5:00PM - 7:15PM
Brain Entry of Cellular Effectors of CNS Inflammation
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 4 of 6
Candice C. Clay, University of California, Davis, USA
Short Talk: CNS Inflammation and Acute Neuroinvasion of Fluorescein+ Monocytes in the Nonhuman Primate Model for AIDS


Wednesday, January 12 | 5:00PM - 7:15PM
Brain Entry of Cellular Effectors of CNS Inflammation
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 5 of 6
Dorian B. McGavern, NINDS, National Institutes of Health, USA
Short Talk: Dendritic Cell Recruitment into the CNS during the Clearance of a Persistent Viral Infection


Wednesday, January 12 | 5:00PM - 7:15PM
Brain Entry of Cellular Effectors of CNS Inflammation
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 6 of 6
Dyana K. Dalton, Dartmouth Medical School, USA
Short Talk: Mechanisms of Protection from CNS Inflammation during Th1-Mediated Autoimmunity: Protective Roles for iNOS in EAE


Wednesday, January 12 | 7:00PM - 8:00PM
Social Hour
Room: Wasatch/Superior/Superior Lobby


Wednesday, January 12 | 7:30PM - 10:00PM
Poster Session 1
Room: Wasatch/Superior/Superior Lobby


Thursday, January 13 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Superior Lobby


Thursday, January 13 | 8:00AM - 11:00AM
New Perspectives in Neurodegeneration: From Prions to Inflam
mation (Joint)

Room: Ballroom 2-3

Speaker 1 of 5
* Pedro R. Lowenstein, University of Michigan School of Medicine, USA

Thursday, January 13 | 8:00AM - 11:00AM
New Perspectives in Neurodegeneration: From Prions to Inflam
mation (Joint)

Room: Ballroom 2-3

Speaker 2 of 5
Adriano M. Aguzzi, University Hospital of Zürich, Switzerland
Immunology and Immunopathology of Prion Infections

Thursday, January 13 | 8:00AM - 11:00AM
New Perspectives in Neurodegeneration: From Prions to Inflam
mation (Joint)

Room: Ballroom 2-3

Speaker 3 of 5
Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
CNS Inflammation: Friend or Foe?


Thursday, January 13 | 8:00AM - 11:00AM
New Perspectives in Neurodegeneration: From Prions to Inflam
mation (Joint)

Room: Ballroom 2-3

Speaker 4 of 5
Neil Mabbott, Institute for Animal Health, UK
Prions and the Immune System: Identifying Targets for Intervention

Thursday, January 13 | 8:00AM - 11:00AM
New Perspectives in Neurodegeneration: From Prions to Inflam
mation (Joint)

Room: Ballroom 2-3

Speaker 5 of 5
Monica J. Carson, University of California, Riverside, USA
Microglia and the Regulation of Autoreactive Immune Responses

Thursday, January 13 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine & Lobby


Thursday, January 13 | 11:00AM - 1:00PM
Poster Setup
Room: Wasatch/Superior/Superior Lobby


Thursday, January 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Wasatch/Superior/Superior Lobby


Thursday, January 13 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Ballroom Mezzanine & Lobby


Thursday, January 13 | 5:00PM - 7:00PM
Modeling Prion Diseases
Room: Ballroom 3

Speaker 1 of 5
* Charles Weissmann, Scripps Institute, USA

Thursday, January 13 | 5:00PM - 7:00PM
Modeling Prion Diseases
Room: Ballroom 3

Speaker 2 of 5
Stanley B. Prusiner, University of California, San Francisco, USA
Mad Cows and Synthetic Prions

Thursday, January 13 | 5:00PM - 7:00PM
Modeling Prion Diseases
Room: Ballroom 3

Speaker 3 of 5
Jean C. Manson, Institute for Animal Health, Edinburgh, UK
Host PrP in the Control of TSE Disease

Thursday, January 13 | 5:00PM - 7:00PM
Modeling Prion Diseases
Room: Ballroom 3

Speaker 4 of 5
Giovanna R. Mallucci, University of Leicester, UK
Targeting Cellular Prion Protein: A New Therapeutic Goal in Prion Disease

Thursday, January 13 | 5:00PM - 7:00PM
Modeling Prion Diseases
Room: Ballroom 3

Speaker 5 of 5
John Collinge, University College London, UK
Title to be Determined

Thursday, January 13 | 5:00PM - 7:15PM
Inflammation: Good or Bad in Neurodegeneration?
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 1 of 7
* V. Wee Yong, University of Calgary, Canada


Thursday, January 13 | 5:00PM - 7:15PM
Inflammation: Good or Bad in Neurodegeneration?
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 2 of 7
Tony Wyss-Coray, Stanford University School of Medicine, USA
Genetic Dissection of Inflammation in Neurodegenerative Diseases


Thursday, January 13 | 5:00PM - 7:15PM
Inflammation: Good or Bad in Neurodegeneration?
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 3 of 7
Vitaly Vasilevko, University of California, Irvine, USA
Short Talk: Affects of Peripheral Inflammation and Age on the Clearance of A-beta in a Transgenic Model of Alzheimer's Disease


Thursday, January 13 | 5:00PM - 7:15PM
Inflammation: Good or Bad in Neurodegeneration?
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 4 of 7
John M. Hallenbeck, National Institutes of Health, USA
Cytokines in the Initiation and Immunomodulation of Stroke


Thursday, January 13 | 5:00PM - 7:15PM
Inflammation: Good or Bad in Neurodegeneration?
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 5 of 7
Stanley H. Appel, Methodist Neurological Institute, USA
Inflammation: The Good, the Bad, and the Ugly: Lessons from ALS and Parkinson's Disease


Thursday, January 13 | 5:00PM - 7:15PM
Inflammation: Good or Bad in Neurodegeneration?
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 6 of 7
Ikuo Tsunoda, Louisiana State University, USA
Short Talk: Is the Lack of Axonal Injury in C57BL/Wlds Mice Beneficial or Detrimental in Animal Models for Multiple Sclerosis?


Thursday, January 13 | 5:00PM - 7:15PM
Inflammation: Good or Bad in Neurodegeneration?
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 7 of 7
Palwinder K. Mander, GlaxoSmithkline, UK
Short Talk: Key Role of NADPH Oxidase and iNOS in Microglial Proliferation and Inflammatory Neurodegeneration


Thursday, January 13 | 7:00PM - 8:00PM
Social Hour
Room: Wasatch/Superior/Superior Lobby


Thursday, January 13 | 7:30PM - 10:00PM
Poster Session 2
Room: Wasatch/Superior/Superior Lobby


Friday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Superior Lobby


Friday, January 14 | 8:00AM - 11:00AM
Workshop: Hot Topics
Room: Ballroom 3

Speaker 1 of 5
* Surachai Supattapone, Dartmouth Medical School, USA
Biochemical Studies of Prion Protein Conformation and Conversion

Friday, January 14 | 8:00AM - 11:00AM
Workshop: Hot Topics
Room: Ballroom 3

Speaker 2 of 5
Gianluigi Zanusso, University of Verona, Italy
Biochemical Fingerprints of Human and Bovine Prions

Friday, January 14 | 8:00AM - 11:00AM
Workshop: Hot Topics
Room: Ballroom 3

Speaker 3 of 5
Jiyan Ma, Ohio State University, USA
Retro-Translocation of PrP to the Cytosol and its Potential Roles in Prion Disease

Friday, January 14 | 8:00AM - 11:00AM
Workshop: Hot Topics
Room: Ballroom 3

Speaker 4 of 5
Sami J. Barmada, Washington University School of Medicine, USA
Short Talk: Visualization of Prion Infection in Transgenic Mice
Expressing GFP-Tagged Prion Protein


Friday, January 14 | 8:00AM - 11:00AM
Workshop: Hot Topics
Room: Ballroom 3

Speaker 5 of 5
Per Hammarström, Linkoping University, Sweden
Short Talk: Novel Conformational Probes for Protein Misfolding Diseases

Friday, January 14 | 8:00AM - 11:15AM
Pathogen-Induced Brain Inflammation: Cause or Consequence?
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 1 of 7
* Iain L. Campbell, University of Sydney, Australia


Friday, January 14 | 8:00AM - 11:15AM
Pathogen-Induced Brain Inflammation: Cause or Consequence?
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 2 of 7
Kenneth C. Williams, Boston College, USA
Activated Monocytes Drive CNS Neuronal Injury in NeuroAIDS: The Role of Virus and CD8 T Lymphocytes Controlling Disease Progression


Friday, January 14 | 8:00AM - 11:15AM
Pathogen-Induced Brain Inflammation: Cause or Consequence?
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 3 of 7
John K. Fazakerley, University of Edinburgh, UK
Innate and Adaptive Immune Responses in Viral Encephalitis


Friday, January 14 | 8:00AM - 11:15AM
Pathogen-Induced Brain Inflammation: Cause or Consequence?
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 4 of 7
Jay A. Nelson, University of Nebraska Medical Center, USA
Short Talk: Proton Magnetic Resonance Spectroscopic Imaging and Neuronal Impairments in a Murine Model of HIV-1 Encephalitis


Friday, January 14 | 8:00AM - 11:15AM
Pathogen-Induced Brain Inflammation: Cause or Consequence?
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 5 of 7
Martina Deckert, University of Cologne, Germany
Immune Reactions in Bacterial and Parasitic Infections of the CNS


Friday, January 14 | 8:00AM - 11:15AM
Pathogen-Induced Brain Inflammation: Cause or Consequence?
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 6 of 7
Robyn S. Klein, Washington University School of Medicine, USA
Short Talk: Neurons are Responsible for CXCL10-Mediated CD8+ T Cell Infiltration in WNV Encephalitis


Friday, January 14 | 8:00AM - 11:15AM
Pathogen-Induced Brain Inflammation: Cause or Consequence?
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 7 of 7
Pedro R. Lowenstein, University of Michigan School of Medicine, USA
Inflammatory and Immune Responses to Viral Vectors for CNS Gene Therapy: Peculiarities, Mechanisms and Consequences


Friday, January 14 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine & Lobby


Friday, January 14 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Ballroom Mezzanine & Lobby


Friday, January 14 | 5:00PM - 7:00PM
Diagnostics and Therapeutics
Room: Ballroom 3

Speaker 1 of 4
* R. Anthony Williamson, The Scripps Research Institute, USA
Antibodies and Prion Biology

Friday, January 14 | 5:00PM - 7:00PM
Diagnostics and Therapeutics
Room: Ballroom 3

Speaker 2 of 4
Qingzhong Kong, Case Western Reserve University, USA
Human Prion Disease

Friday, January 14 | 5:00PM - 7:00PM
Diagnostics and Therapeutics
Room: Ballroom 3

Speaker 3 of 4
Herbert Budka, Medical University of Vienna, Austria

Friday, January 14 | 5:00PM - 7:00PM
Diagnostics and Therapeutics
Room: Ballroom 3

Speaker 4 of 4
David Peretz, Novartis, USA
Short Talk

Friday, January 14 | 5:00PM - 7:00PM
Inflammation, Stem Cells and Neurogenesis
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 1 of 5
* Francesca Aloisi, Instituto Superior de Sanita, Italy


Friday, January 14 | 5:00PM - 7:00PM
Inflammation, Stem Cells and Neurogenesis
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 2 of 5
Theo D. Palmer, Stanford University Medical Center, USA
Inflammatory Modulation of Adult Hippocampal Neurogenesis


Friday, January 14 | 5:00PM - 7:00PM
Inflammation, Stem Cells and Neurogenesis
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 3 of 5
Larisa Poluektova, University of Nebraska Medical Center, USA
Short Talk: HIV-1 Encephalitis Affects Hippocampal Neurogenesis


Friday, January 14 | 5:00PM - 7:00PM
Inflammation, Stem Cells and Neurogenesis
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 4 of 5
Evan Snyder, Sanford-Burnham Medical Research Institute, USA
Inflammation, Stem Cells and Neurogenesis


Friday, January 14 | 5:00PM - 7:00PM
Inflammation, Stem Cells and Neurogenesis
This session is from CNS Inflammation
Room: Ballroom 2

Speaker 5 of 5
Gianvito Martino, San Raffaele Scientific Institute, Italy
Neural Stem Cells as a Neuroprotective Therapy in Inflammatory Demyelinating Disorders


Friday, January 14 | 8:00PM - 9:00PM
Social Hour
Room: Ballroom 1-3


Friday, January 14 | 8:00PM - 11:00PM
Entertainment
Room: Ballroom 1-3


Friday, January 14 | 9:00PM - 11:00PM
Cash Bar
Room: Ballroom 1-3


Saturday, January 15 | 10:26AM - 10:26AM
Departure


*Session Chair.