Web Desc
Central Nervous System Inflammation: Mechanisms, Consequences and Therapeutic Strategies
joint with Molecular Mechanisms of Transmissible Spongiform Encephalopathies (Prion Diseases)
Organizer(s): Scott R. Barnum, Iain L. Campbell and Pedro R. Lowenstein
Date: January 11 - 15, 2005
Location: Snowbird Resort, Snowbird, UT, USA
Sponsored by Sanofi-Aventis Pharmaceuticals, Inc. and The Director's Fund
Summary of Meeting:
Knowledge of the immunologic and inflammatory mechanisms contributing to acute and chronic central nervous system (CNS) diseases has increased dramatically in recent years. Inflammatory mediators and cellular processes once thought to be restricted to peripheral immune responses are now known to be central to the pathogenesis of many important CNS diseases, such as multiple sclerosis, Alzheimer's disease, stroke, HIV-dementia and others. Immune cell recruitment and regulation in the brain are known to be molded by the CNS environment where cells such as the microglia and astrocytes elaborate a variety of potent regulatory mediators. The mediators include an expanding array of cytokines, chemokines, proteases, as well as, complement proteins and reactive oxygen species. Determining the role of these mediators in CNS disease has been advanced considerably by the development of transgenic and knockout animal models. These animal models have, in many cases, provided unexpected results, thus broadening our understanding of inflammatory mechanisms in the CNS. This meeting will address recent advances in basic mechanisms, model approaches and novel therapies in immunologic and inflammatory diseases of the CNS and promote the interaction of basic and clinical researchers from diverse fields representing academia and industry.
Discounted Abstract Deadline: September 17 2004
Discounted Registration Deadline: November 11 2004
We gratefully acknowledge additional support for this conference from:
AlzheimerSanofi US
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Educational grant from Lilly USA, LLC
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13-NS050910-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, January 11 | 3:00PM - 7:30PM
Registration
Room: Ballroom Lobby


Tuesday, January 11 | 6:30PM - 7:30PM
Refreshments
Room: Ballroom Mezzanine & Lobby


Tuesday, January 11 | 7:30PM - 8:30PM
Keynote Address
Room: Ballroom 2

Speaker 1 of 2
* Scott R. Barnum, University of Alabama, Birmingham, USA

Tuesday, January 11 | 7:30PM - 8:30PM
Keynote Address
Room: Ballroom 2

Speaker 2 of 2
Jonathon D. Sedgwick, Eli Lilly and Company, USA
Insights at the Molecular Level of Cell-Cell Interactions Modulating Microglial Cell Activation and Brain Inflammation

Wednesday, January 12 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Superior Lobby


Wednesday, January 12 | 8:00AM - 11:15AM
Molecular Effectors of CNS Inflammation
Room: Ballroom 2

Speaker 1 of 4
* Trevor Owens, University of Southern Denmark, Denmark
Immune-glial interactions in induction and regulation of CNS inflammation

Wednesday, January 12 | 8:00AM - 11:15AM
Molecular Effectors of CNS Inflammation
Room: Ballroom 2

Speaker 2 of 4
Iain L. Campbell, University of Sydney, Australia
Cytokine Signaling in CNS Inflammation and Disease


Wednesday, January 12 | 8:00AM - 11:15AM
Molecular Effectors of CNS Inflammation
Room: Ballroom 2

Speaker 3 of 4
Scott R. Barnum, University of Alabama, Birmingham, USA
Complement and Demyelinating Disease: Not as Simple as We Thought

Wednesday, January 12 | 8:00AM - 11:15AM
Molecular Effectors of CNS Inflammation
Room: Ballroom 2

Speaker 4 of 4
V. Wee Yong, University of Calgary, Canada
Matrix Metalloproteinases

Wednesday, January 12 | 8:00AM - 11:00AM
TSE in Humans and Animals
This session is from TSE Diseases
Room: Ballroom 3

Speaker 1 of 6
* Jean C. Manson, Institute for Animal Health, Edinburgh, UK


Wednesday, January 12 | 8:00AM - 11:00AM
TSE in Humans and Animals
This session is from TSE Diseases
Room: Ballroom 3

Speaker 2 of 6
Gino Miele, University Hospital of Zürich, Switzerland
Transcription Profiling of Prion Diseases


Wednesday, January 12 | 8:00AM - 11:00AM
TSE in Humans and Animals
This session is from TSE Diseases
Room: Ballroom 3

Speaker 3 of 6
Markus Glatzel, Hamburg University, Germany
Peripheral Pathogenesis of Human Prion Diseases


Wednesday, January 12 | 8:00AM - 11:00AM
TSE in Humans and Animals
This session is from TSE Diseases
Room: Ballroom 3

Speaker 4 of 6
Suzette A. Priola, Rocky Mountain Laboratories, NIAID, National Institutes of Health, USA
Acute versus Persistent PrP-res Formation during Establishment of a TSE Infection


Wednesday, January 12 | 8:00AM - 11:00AM
TSE in Humans and Animals
This session is from TSE Diseases
Room: Ballroom 3

Speaker 5 of 6
George A. Carlson, McLaughlin Research Institute, USA
Short Talk: Dissection of Genetic Susceptibility to Prion Disease In Vivo and In Vitro


Wednesday, January 12 | 8:00AM - 11:00AM
TSE in Humans and Animals
This session is from TSE Diseases
Room: Ballroom 3

Speaker 6 of 6
Richard S. Stewart, Washington University School of Medicine, USA
Short Talk: Neurodegenerative Illness Induced in Transgenic Mice by Transmembrane PrP is Dependent upon Expression of Endogenous PrP


Wednesday, January 12 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine & Lobby


Wednesday, January 12 | 11:00AM - 1:00PM
Poster Setup
Room: Wasatch/Superior/Superior Lobby


Wednesday, January 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Wasatch/Superior/Superior Lobby


Wednesday, January 12 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Ballroom Mezzanine & Lobby


Wednesday, January 12 | 5:00PM - 7:15PM
Brain Entry of Cellular Effectors of CNS Inflammation
Room: Ballroom 2

Speaker 1 of 6
* Richard M. Ransohoff, Third Rock Ventures, USA
Chemokines

Wednesday, January 12 | 5:00PM - 7:15PM
Brain Entry of Cellular Effectors of CNS Inflammation
Room: Ballroom 2

Speaker 2 of 6
Britta Engelhardt, Theodor Kocher Institute/Universitat Bern, Switzerland
Molecular Steps involved in T lymphocyte migration across the blood-brain barrier

Wednesday, January 12 | 5:00PM - 7:15PM
Brain Entry of Cellular Effectors of CNS Inflammation
Room: Ballroom 2

Speaker 3 of 6
Francesca Aloisi, Instituto Superior de Sanita, Italy
Lymphod neogenesis in the inflamed CNS

Wednesday, January 12 | 5:00PM - 7:15PM
Brain Entry of Cellular Effectors of CNS Inflammation
Room: Ballroom 2

Speaker 4 of 6
Candice C. Clay, University of California, Davis, USA
Short Talk: CNS Inflammation and Acute Neuroinvasion of Fluorescein+ Monocytes in the Nonhuman Primate Model for AIDS

Wednesday, January 12 | 5:00PM - 7:15PM
Brain Entry of Cellular Effectors of CNS Inflammation
Room: Ballroom 2

Speaker 5 of 6
Dorian B. McGavern, NINDS, National Institutes of Health, USA
Short Talk: Dendritic Cell Recruitment into the CNS during the Clearance of a Persistent Viral Infection

Wednesday, January 12 | 5:00PM - 7:15PM
Brain Entry of Cellular Effectors of CNS Inflammation
Room: Ballroom 2

Speaker 6 of 6
Dyana K. Dalton, Dartmouth Medical School, USA
Short Talk: Mechanisms of Protection from CNS Inflammation during Th1-Mediated Autoimmunity: Protective Roles for iNOS in EAE

Wednesday, January 12 | 5:00PM - 7:00PM
Structure and Propagation of Prion Proteins
This session is from TSE Diseases
Room: Ballroom 3

Speaker 1 of 4
* Susan Lindquist, HHMI/Whitehead Institute for Biomedical Research, USA
Prion Assembly and Disassembly


Wednesday, January 12 | 5:00PM - 7:00PM
Structure and Propagation of Prion Proteins
This session is from TSE Diseases
Room: Ballroom 3

Speaker 2 of 4
Byron Caughey, Rocky Mountain Laboratories, NIAID, National Institutes of Health, USA
Uptake and Neuritic Transport of PrP-res Coincident with Scrapie Infection of Neuronal Cells


Wednesday, January 12 | 5:00PM - 7:00PM
Structure and Propagation of Prion Proteins
This session is from TSE Diseases
Room: Ballroom 3

Speaker 3 of 4
Reed B. Wickner, National Institutes of Health, USA
The [URE3] Prion: Ure2p Prion Domain and Prion Generation


Wednesday, January 12 | 5:00PM - 7:00PM
Structure and Propagation of Prion Proteins
This session is from TSE Diseases
Room: Ballroom 3

Speaker 4 of 4
Ilia V. Baskakov, University of Maryland School of Medicine, USA
Short Talk: The First Synthetic Mammalian Prion


Wednesday, January 12 | 7:00PM - 8:00PM
Social Hour
Room: Wasatch/Superior/Superior Lobby


Wednesday, January 12 | 7:30PM - 10:00PM
Poster Session 1
Room: Wasatch/Superior/Superior Lobby


Thursday, January 13 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Superior Lobby


Thursday, January 13 | 8:00AM - 11:00AM
New Perspectives in Neurodegeneration: From Prions to Inflam
mation (Joint)

Room: Ballroom 2-3

Speaker 1 of 5
* Pedro R. Lowenstein, University of Michigan School of Medicine, USA

Thursday, January 13 | 8:00AM - 11:00AM
New Perspectives in Neurodegeneration: From Prions to Inflam
mation (Joint)

Room: Ballroom 2-3

Speaker 2 of 5
Adriano M. Aguzzi, University Hospital of Zürich, Switzerland
Immunology and Immunopathology of Prion Infections

Thursday, January 13 | 8:00AM - 11:00AM
New Perspectives in Neurodegeneration: From Prions to Inflam
mation (Joint)

Room: Ballroom 2-3

Speaker 3 of 5
Jenny P.Y. Ting, University of North Carolina at Chapel Hill, USA
CNS Inflammation: Friend or Foe?

Thursday, January 13 | 8:00AM - 11:00AM
New Perspectives in Neurodegeneration: From Prions to Inflam
mation (Joint)

Room: Ballroom 2-3

Speaker 4 of 5
Neil Mabbott, Institute for Animal Health, UK
Prions and the Immune System: Identifying Targets for Intervention

Thursday, January 13 | 8:00AM - 11:00AM
New Perspectives in Neurodegeneration: From Prions to Inflam
mation (Joint)

Room: Ballroom 2-3

Speaker 5 of 5
Monica J. Carson, University of California, Riverside, USA
Microglia and the Regulation of Autoreactive Immune Responses

Thursday, January 13 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine & Lobby


Thursday, January 13 | 11:00AM - 1:00PM
Poster Setup
Room: Wasatch/Superior/Superior Lobby


Thursday, January 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Wasatch/Superior/Superior Lobby


Thursday, January 13 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Ballroom Mezzanine & Lobby


Thursday, January 13 | 5:00PM - 7:15PM
Inflammation: Good or Bad in Neurodegeneration?
Room: Ballroom 2

Speaker 1 of 7
* V. Wee Yong, University of Calgary, Canada

Thursday, January 13 | 5:00PM - 7:15PM
Inflammation: Good or Bad in Neurodegeneration?
Room: Ballroom 2

Speaker 2 of 7
Tony Wyss-Coray, Stanford University School of Medicine, USA
Genetic Dissection of Inflammation in Neurodegenerative Diseases

Thursday, January 13 | 5:00PM - 7:15PM
Inflammation: Good or Bad in Neurodegeneration?
Room: Ballroom 2

Speaker 3 of 7
Vitaly Vasilevko, University of California, Irvine, USA
Short Talk: Affects of Peripheral Inflammation and Age on the Clearance of A-beta in a Transgenic Model of Alzheimer's Disease

Thursday, January 13 | 5:00PM - 7:15PM
Inflammation: Good or Bad in Neurodegeneration?
Room: Ballroom 2

Speaker 4 of 7
John M. Hallenbeck, National Institutes of Health, USA
Cytokines in the Initiation and Immunomodulation of Stroke

Thursday, January 13 | 5:00PM - 7:15PM
Inflammation: Good or Bad in Neurodegeneration?
Room: Ballroom 2

Speaker 5 of 7
Stanley H. Appel, Methodist Neurological Institute, USA
Inflammation: The Good, the Bad, and the Ugly: Lessons from ALS and Parkinson's Disease

Thursday, January 13 | 5:00PM - 7:15PM
Inflammation: Good or Bad in Neurodegeneration?
Room: Ballroom 2

Speaker 6 of 7
Ikuo Tsunoda, Louisiana State University, USA
Short Talk: Is the Lack of Axonal Injury in C57BL/Wlds Mice Beneficial or Detrimental in Animal Models for Multiple Sclerosis?

Thursday, January 13 | 5:00PM - 7:15PM
Inflammation: Good or Bad in Neurodegeneration?
Room: Ballroom 2

Speaker 7 of 7
Palwinder K. Mander, GlaxoSmithkline, UK
Short Talk: Key Role of NADPH Oxidase and iNOS in Microglial Proliferation and Inflammatory Neurodegeneration

Thursday, January 13 | 5:00PM - 7:00PM
Modeling Prion Diseases
This session is from TSE Diseases
Room: Ballroom 3

Speaker 1 of 5
* Charles Weissmann, Scripps Institute, USA


Thursday, January 13 | 5:00PM - 7:00PM
Modeling Prion Diseases
This session is from TSE Diseases
Room: Ballroom 3

Speaker 2 of 5
Stanley B. Prusiner, University of California, San Francisco, USA
Mad Cows and Synthetic Prions


Thursday, January 13 | 5:00PM - 7:00PM
Modeling Prion Diseases
This session is from TSE Diseases
Room: Ballroom 3

Speaker 3 of 5
Jean C. Manson, Institute for Animal Health, Edinburgh, UK
Host PrP in the Control of TSE Disease


Thursday, January 13 | 5:00PM - 7:00PM
Modeling Prion Diseases
This session is from TSE Diseases
Room: Ballroom 3

Speaker 4 of 5
Giovanna R. Mallucci, University of Leicester, UK
Targeting Cellular Prion Protein: A New Therapeutic Goal in Prion Disease


Thursday, January 13 | 5:00PM - 7:00PM
Modeling Prion Diseases
This session is from TSE Diseases
Room: Ballroom 3

Speaker 5 of 5
John Collinge, University College London, UK
Title to be Determined


Thursday, January 13 | 7:00PM - 8:00PM
Social Hour
Room: Wasatch/Superior/Superior Lobby


Thursday, January 13 | 7:30PM - 10:00PM
Poster Session 2
Room: Wasatch/Superior/Superior Lobby


Friday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Superior Lobby


Friday, January 14 | 8:00AM - 11:15AM
Pathogen-Induced Brain Inflammation: Cause or Consequence?
Room: Ballroom 2

Speaker 1 of 7
* Iain L. Campbell, University of Sydney, Australia

Friday, January 14 | 8:00AM - 11:15AM
Pathogen-Induced Brain Inflammation: Cause or Consequence?
Room: Ballroom 2

Speaker 2 of 7
Kenneth C. Williams, Boston College, USA
Activated Monocytes Drive CNS Neuronal Injury in NeuroAIDS: The Role of Virus and CD8 T Lymphocytes Controlling Disease Progression

Friday, January 14 | 8:00AM - 11:15AM
Pathogen-Induced Brain Inflammation: Cause or Consequence?
Room: Ballroom 2

Speaker 3 of 7
John K. Fazakerley, University of Edinburgh, UK
Innate and Adaptive Immune Responses in Viral Encephalitis

Friday, January 14 | 8:00AM - 11:15AM
Pathogen-Induced Brain Inflammation: Cause or Consequence?
Room: Ballroom 2

Speaker 4 of 7
Jay A. Nelson, University of Nebraska Medical Center, USA
Short Talk: Proton Magnetic Resonance Spectroscopic Imaging and Neuronal Impairments in a Murine Model of HIV-1 Encephalitis

Friday, January 14 | 8:00AM - 11:15AM
Pathogen-Induced Brain Inflammation: Cause or Consequence?
Room: Ballroom 2

Speaker 5 of 7
Martina Deckert, University of Cologne, Germany
Immune Reactions in Bacterial and Parasitic Infections of the CNS

Friday, January 14 | 8:00AM - 11:15AM
Pathogen-Induced Brain Inflammation: Cause or Consequence?
Room: Ballroom 2

Speaker 6 of 7
Robyn S. Klein, Washington University School of Medicine, USA
Short Talk: Neurons are Responsible for CXCL10-Mediated CD8+ T Cell Infiltration in WNV Encephalitis

Friday, January 14 | 8:00AM - 11:15AM
Pathogen-Induced Brain Inflammation: Cause or Consequence?
Room: Ballroom 2

Speaker 7 of 7
Pedro R. Lowenstein, University of Michigan School of Medicine, USA
Inflammatory and Immune Responses to Viral Vectors for CNS Gene Therapy: Peculiarities, Mechanisms and Consequences

Friday, January 14 | 8:00AM - 11:00AM
Workshop: Hot Topics
This session is from TSE Diseases
Room: Ballroom 3

Speaker 1 of 5
* Surachai Supattapone, Dartmouth Medical School, USA
Biochemical Studies of Prion Protein Conformation and Conversion


Friday, January 14 | 8:00AM - 11:00AM
Workshop: Hot Topics
This session is from TSE Diseases
Room: Ballroom 3

Speaker 2 of 5
Gianluigi Zanusso, University of Verona, Italy
Biochemical Fingerprints of Human and Bovine Prions


Friday, January 14 | 8:00AM - 11:00AM
Workshop: Hot Topics
This session is from TSE Diseases
Room: Ballroom 3

Speaker 3 of 5
Jiyan Ma, Ohio State University, USA
Retro-Translocation of PrP to the Cytosol and its Potential Roles in Prion Disease


Friday, January 14 | 8:00AM - 11:00AM
Workshop: Hot Topics
This session is from TSE Diseases
Room: Ballroom 3

Speaker 4 of 5
Sami J. Barmada, Washington University School of Medicine, USA
Short Talk: Visualization of Prion Infection in Transgenic Mice
Expressing GFP-Tagged Prion Protein


Friday, January 14 | 8:00AM - 11:00AM
Workshop: Hot Topics
This session is from TSE Diseases
Room: Ballroom 3

Speaker 5 of 5
Per Hammarström, Linkoping University, Sweden
Short Talk: Novel Conformational Probes for Protein Misfolding Diseases


Friday, January 14 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine & Lobby


Friday, January 14 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Ballroom Mezzanine & Lobby


Friday, January 14 | 5:00PM - 7:00PM
Inflammation, Stem Cells and Neurogenesis
Room: Ballroom 2

Speaker 1 of 5
* Francesca Aloisi, Instituto Superior de Sanita, Italy

Friday, January 14 | 5:00PM - 7:00PM
Inflammation, Stem Cells and Neurogenesis
Room: Ballroom 2

Speaker 2 of 5
Theo D. Palmer, Stanford University Medical Center, USA
Inflammatory Modulation of Adult Hippocampal Neurogenesis

Friday, January 14 | 5:00PM - 7:00PM
Inflammation, Stem Cells and Neurogenesis
Room: Ballroom 2

Speaker 3 of 5
Larisa Poluektova, University of Nebraska Medical Center, USA
Short Talk: HIV-1 Encephalitis Affects Hippocampal Neurogenesis

Friday, January 14 | 5:00PM - 7:00PM
Inflammation, Stem Cells and Neurogenesis
Room: Ballroom 2

Speaker 4 of 5
Evan Snyder, Sanford-Burnham Medical Research Institute, USA
Inflammation, Stem Cells and Neurogenesis

Friday, January 14 | 5:00PM - 7:00PM
Inflammation, Stem Cells and Neurogenesis
Room: Ballroom 2

Speaker 5 of 5
Gianvito Martino, San Raffaele Scientific Institute, Italy
Neural Stem Cells as a Neuroprotective Therapy in Inflammatory Demyelinating Disorders

Friday, January 14 | 5:00PM - 7:00PM
Diagnostics and Therapeutics
This session is from TSE Diseases
Room: Ballroom 3

Speaker 1 of 4
* R. Anthony Williamson, The Scripps Research Institute, USA
Antibodies and Prion Biology


Friday, January 14 | 5:00PM - 7:00PM
Diagnostics and Therapeutics
This session is from TSE Diseases
Room: Ballroom 3

Speaker 2 of 4
Qingzhong Kong, Case Western Reserve University, USA
Human Prion Disease


Friday, January 14 | 5:00PM - 7:00PM
Diagnostics and Therapeutics
This session is from TSE Diseases
Room: Ballroom 3

Speaker 3 of 4
Herbert Budka, Medical University of Vienna, Austria


Friday, January 14 | 5:00PM - 7:00PM
Diagnostics and Therapeutics
This session is from TSE Diseases
Room: Ballroom 3

Speaker 4 of 4
David Peretz, Novartis, USA
Short Talk


Friday, January 14 | 8:00PM - 9:00PM
Social Hour
Room: Ballroom 1-3


Friday, January 14 | 8:00PM - 11:00PM
Entertainment
Room: Ballroom 1-3


Friday, January 14 | 9:00PM - 11:00PM
Cash Bar
Room: Ballroom 1-3


Saturday, January 15 | 10:26AM - 10:26AM
Departure


*Session Chair.