Web Desc
Obesity: Molecular Physiology and Genetics of the Control of Body Weight
joint with Diabetes Mellitus: Molecular Mechanisms, Genetics and New Therapies
Organizer(s): Rudolph L. Leibel and Joel K. Elmquist
Date: January 27 - February 02, 2005
Location: Keystone Resort, Keystone, CO, USA
Sponsored by Biovitrum AB, Cell Press and Lilly Research Laboratories
Summary of Meeting:
The rapid increase in the prevalence of obesity in developed and developing countries constitutes a major threat to the health of individuals, and the medical economics of their countries. Obesity accounts for major fractions of type 2 diabetes, dyslipidemias, hypertension and stroke, and a growing proportion of certain cancers. The past decade has seen impressive advances in the elucidation of the molecular genetics and molecular physiology of the control of body weight and composition. However, this understanding has not yet been translated into successful preventive or therapeutic approaches to the disease. Likewise, the molecular bases for the relationship of obesity to most of the medical sequelae mentioned above remain unknown. The purpose of this meeting is to bring together scientists working on the molecular genetics and physiology of energy homeostasis with investigators seeking to understand aspects of the systemic physiology and environment that are interacting with clear genetic predisposition to increase the prevalence. Investigators have been selected for their contributions to the understanding of specific aspects of the molecular and systemic control of body weight, and the contributions of developmental and environmental factors, as well as for their interest in the functional mechanisms by which these interact.
Discounted Abstract Deadline: September 27 2004
Discounted Registration Deadline: November 29 2004
We gratefully acknowledge additional support for this conference from:
Biovitrum ABCell PressLilly Research Laboratories
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Roche Palo Alto
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1R13-DK070429-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, January 27 | 3:00PM - 7:30PM
Registration
Room: Grays Peak Foyer


Thursday, January 27 | 6:30PM - 7:30PM
Refreshments
Room: Longs Peak Foyer


Thursday, January 27 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Longs/Quandary Peak

Speaker 1 of 4
* Rudolph L. Leibel, Columbia University, USA

Thursday, January 27 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Longs/Quandary Peak

Speaker 2 of 4
* Morris J. Birnbaum, Pfizer Inc., USA

Thursday, January 27 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Longs/Quandary Peak

Speaker 3 of 4
C. Nick Hales, UK
The Effects of Fetal and Infant Growth on Susceptibility to Obesity, Diabetes and Renal Disease and on Longevity

Thursday, January 27 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Longs/Quandary Peak

Speaker 4 of 4
Donald F. Steiner, University Of Chicago, USA
A Diabetes Research Perspective

Friday, January 28 | 7:00AM - 8:00AM
Breakfast
Room: Grays Peak


Friday, January 28 | 8:00AM - 11:15AM
Central Regulation of Energy Homeostasis (Joint)
Room: Longs/Quandary Peak

Speaker 1 of 7
Joel K. Elmquist, University of Texas Southwestern Medical Center, USA

Friday, January 28 | 8:00AM - 11:15AM
Central Regulation of Energy Homeostasis (Joint)
Room: Longs/Quandary Peak

Speaker 2 of 7
Luciano Rossetti, Merck Research Laboratories, USA
Metabolic Sensing in the Brain

Friday, January 28 | 8:00AM - 11:15AM
Central Regulation of Energy Homeostasis (Joint)
Room: Longs/Quandary Peak

Speaker 3 of 7
Michael W. Schwartz, University of Washington, USA
Hormonal Mediation of Energy Homeostasis

Friday, January 28 | 8:00AM - 11:15AM
Central Regulation of Energy Homeostasis (Joint)
Room: Longs/Quandary Peak

Speaker 4 of 7
Martin G. Myers, Jr., University of Michigan, USA
Molecular Analysis of Leptin Receptor Function and Energy Homeostasis

Friday, January 28 | 8:00AM - 11:15AM
Central Regulation of Energy Homeostasis (Joint)
Room: Longs/Quandary Peak

Speaker 5 of 7
Jeffrey M. Friedman, Rockefeller University, USA
To Eat or Not to Eat

Friday, January 28 | 8:00AM - 11:15AM
Central Regulation of Energy Homeostasis (Joint)
Room: Longs/Quandary Peak

Speaker 6 of 7
Jonathan Dean Hommel, University of Texas Medical Branch, USA
Short Talk: Leptin Signals Directly to Dopamine Neurons of the VTA to Regulate Feeding Behavior

Friday, January 28 | 8:00AM - 11:15AM
Central Regulation of Energy Homeostasis (Joint)
Room: Longs/Quandary Peak

Speaker 7 of 7
Min-Seon Kim, University of Ulsan College of Medicine, South Korea
Short Talk: Role of Forkhead Transcription Factor FOXO1 in the Regulation of Feeding

Friday, January 28 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Friday, January 28 | 11:15AM - 1:00PM
Poster Setup
Room: Torreys Peak


Friday, January 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys Peak


Friday, January 28 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Friday, January 28 | 5:00PM - 7:00PM
Central Actions of Metabolic Signals
Room: Quandary Peak

Speaker 1 of 5
* Kevin L. Grove, Novo Nordisk, USA

Friday, January 28 | 5:00PM - 7:00PM
Central Actions of Metabolic Signals
Room: Quandary Peak

Speaker 2 of 5
Rachel L. Batterham, University College London, UK
The Role of PYY in Regulating Energy Homeostasis in Man

Friday, January 28 | 5:00PM - 7:00PM
Central Actions of Metabolic Signals
Room: Quandary Peak

Speaker 3 of 5
Richard B. Simerly, Vanderbilt University, USA
Leptin and Hypothalamic Neural Development

Friday, January 28 | 5:00PM - 7:00PM
Central Actions of Metabolic Signals
Room: Quandary Peak

Speaker 4 of 5
Harvey J. Grill, University of Pennsylvania, USA
Contributions of Caudal Brainstem and Hypothalamus to The Neurobiology of Energy Balance

Friday, January 28 | 5:00PM - 7:00PM
Central Actions of Metabolic Signals
Room: Quandary Peak

Speaker 5 of 5
Suzanne M. Appleyard, Washington State University, USA
Short Talk: Appetite Regulators Interact at NTS POMC-EGFP Neurons Activated by Visceral Afferent Inputs

Friday, January 28 | 5:00PM - 7:00PM
Insulin-Dependent Signaling Pathways
This session is from Diabetes Mellitus
Room: Longs Peak

Speaker 1 of 5
* Thomas A. Gustafson, Johnson and Johnson, USA


Friday, January 28 | 5:00PM - 7:00PM
Insulin-Dependent Signaling Pathways
This session is from Diabetes Mellitus
Room: Longs Peak

Speaker 2 of 5
Michael P. Czech, University of Massachusetts Medical School, USA
Targets of Phosphoinositide Signaling


Friday, January 28 | 5:00PM - 7:00PM
Insulin-Dependent Signaling Pathways
This session is from Diabetes Mellitus
Room: Longs Peak

Speaker 3 of 5
Alan R. Saltiel, University of California, San Diego, USA
Spatial Compartmentalization of Signal Transduction in Insulin Action


Friday, January 28 | 5:00PM - 7:00PM
Insulin-Dependent Signaling Pathways
This session is from Diabetes Mellitus
Room: Longs Peak

Speaker 4 of 5
Morris J. Birnbaum, Pfizer Inc., USA
Achieving Specificity in Signaling to Growth and Metabolism


Friday, January 28 | 5:00PM - 7:00PM
Insulin-Dependent Signaling Pathways
This session is from Diabetes Mellitus
Room: Longs Peak

Speaker 5 of 5
Feng Liu, University of Texas Health Science Center, USA
Short Talk: Insulin Stimulates PDK1 Phosphorylation at Ser163: A Mechanism for Activation


Friday, January 28 | 7:00PM - 8:00PM
Social Hour
Room: Longs Peak Foyer


Friday, January 28 | 7:30PM - 10:00PM
Poster Session 1
Room: Torreys Peak


Saturday, January 29 | 7:00AM - 8:00AM
Breakfast
Room: Grays Peak


Saturday, January 29 | 8:00AM - 11:15AM
Adipose Tissue Mediated Effects on Energy Homeostasis (Joint
)

Room: Longs/Quandary Peak

Speaker 1 of 7
* Marc L. Reitman, NIDDK, National Institutes of Health, USA

Saturday, January 29 | 8:00AM - 11:15AM
Adipose Tissue Mediated Effects on Energy Homeostasis (Joint
)

Room: Longs/Quandary Peak

Speaker 2 of 7
C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
New Insights in the Development and Function of Brown Fat and its Role in Metabolic Syndrome Studied by Gene Expressin Analysis

Saturday, January 29 | 8:00AM - 11:15AM
Adipose Tissue Mediated Effects on Energy Homeostasis (Joint
)

Room: Longs/Quandary Peak

Speaker 3 of 7
Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Resistin as a Regulator of Metabolism

Saturday, January 29 | 8:00AM - 11:15AM
Adipose Tissue Mediated Effects on Energy Homeostasis (Joint
)

Room: Longs/Quandary Peak

Speaker 4 of 7
Bradford B. Lowell, Beth Israel Deaconess Medical Center, USA
Superoxide and Mitochondrial Uncoupling Protein-2: A Pathway Linking Obesity and Hyperglycemia with Beta-Cell Dysfunction

Saturday, January 29 | 8:00AM - 11:15AM
Adipose Tissue Mediated Effects on Energy Homeostasis (Joint
)

Room: Longs/Quandary Peak

Speaker 5 of 7
Bruce M. Spiegelman, Harvard Medical School, USA
Role of the PGC Coactivators in Lipid and Energy Metabolism

Saturday, January 29 | 8:00AM - 11:15AM
Adipose Tissue Mediated Effects on Energy Homeostasis (Joint
)

Room: Longs/Quandary Peak

Speaker 6 of 7
Iichiro Shimomura, Osaka University, Japan
Short Talk: Visfatin; A New Adipocytokine Secreted from Accumulated Visceral Fat

Saturday, January 29 | 8:00AM - 11:15AM
Adipose Tissue Mediated Effects on Energy Homeostasis (Joint
)

Room: Longs/Quandary Peak

Speaker 7 of 7
Yuka Toyoshima, Nippon Medical School, Japan
Short Talk: Leptin Improves Insulin Resistance and Hyperglycemia in a Mouse Model of Type 2 Diabetes

Saturday, January 29 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Saturday, January 29 | 11:15AM - 1:00PM
Poster Setup
Room: Torreys Peak


Saturday, January 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys Peak


Saturday, January 29 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Saturday, January 29 | 5:00PM - 7:00PM
Other Molecular Pathways Related to Energy Homeostasis
Room: Quandary Peak

Speaker 1 of 5
* Matthias H. Tschöp, Helmholtz Zentrum München and Technische Universität München, Germany

Saturday, January 29 | 5:00PM - 7:00PM
Other Molecular Pathways Related to Energy Homeostasis
Room: Quandary Peak

Speaker 2 of 5
Gregory S. Barsh, Stanford University Medical Center, USA
Melanocortin Pathway in Energy Homeostasis


Saturday, January 29 | 5:00PM - 7:00PM
Other Molecular Pathways Related to Energy Homeostasis
Room: Quandary Peak

Speaker 3 of 5
Eleftheria Maratos-Flier, Beth Israel Deaconess Medical Center, USA
The Multiple Roles of Melanin-Concentrating Hormone in Regulating Energy Balance

Saturday, January 29 | 5:00PM - 7:00PM
Other Molecular Pathways Related to Energy Homeostasis
Room: Quandary Peak

Speaker 4 of 5
Michael A. Cowley, Monash University, Australia
Hypothalamic Arcuate Melanocortin Neurons Integrate Signals of Energy State


Saturday, January 29 | 5:00PM - 7:00PM
Other Molecular Pathways Related to Energy Homeostasis
Room: Quandary Peak

Speaker 5 of 5
William F. Colmers, University of Alberta, Canada
Short Talk: Cannabinoid Antagonist Acts like Melanocortin Agonist in MpPVN

Saturday, January 29 | 5:00PM - 7:00PM
Cell Biology of the Beta Cell and Adipocyte
This session is from Diabetes Mellitus
Room: Longs Peak

Speaker 1 of 5
David E. James, University of Sydney, Australia
Insulin Regulation of Glucose Transport in Adipocytes


Saturday, January 29 | 5:00PM - 7:00PM
Cell Biology of the Beta Cell and Adipocyte
This session is from Diabetes Mellitus
Room: Longs Peak

Speaker 2 of 5
Michele Solimena, Dresden University of Technology, Germany
Secretory Granules: Biogenesis and Signaling


Saturday, January 29 | 5:00PM - 7:00PM
Cell Biology of the Beta Cell and Adipocyte
This session is from Diabetes Mellitus
Room: Longs Peak

Speaker 3 of 5
Per-Olof Berggren, Karolinska Institutet, Sweden
Voltage-Gated L-Type Ca2+ Channels in beta-Cell Physiology and Pathophysiology


Saturday, January 29 | 5:00PM - 7:00PM
Cell Biology of the Beta Cell and Adipocyte
This session is from Diabetes Mellitus
Room: Longs Peak

Speaker 4 of 5
Toshio Hosaka, Boston University, USA
Short Talk: p115 Interacts with the GLUT4 Vesicle Protein, IRAP, and Plays a Critical Role in Insulin-Stimulated GLUT4 Translocation


Saturday, January 29 | 5:00PM - 7:00PM
Cell Biology of the Beta Cell and Adipocyte
This session is from Diabetes Mellitus
Room: Longs Peak

Speaker 5 of 5
* Timothy E. McGraw, Weill Medical College of Cornell University, USA


Saturday, January 29 | 7:00PM - 8:00PM
Social Hour
Room: Longs Peak Foyer


Saturday, January 29 | 7:30PM - 10:00PM
Poster Session 2
Room: Torreys Peak


Sunday, January 30 | 7:00AM - 8:00AM
Breakfast
Room: Grays Peak


Sunday, January 30 | 8:00AM - 11:15AM
Diabetes and Obesity in Non-Mammalian Organisms (Joint)
Room: Longs/Quandary Peak

Speaker 1 of 7
* Helena Edlund, Umeå University, Sweden

Sunday, January 30 | 8:00AM - 11:15AM
Diabetes and Obesity in Non-Mammalian Organisms (Joint)
Room: Longs/Quandary Peak

Speaker 2 of 7
Eric Rulifson, University of California, San Francisco, USA
Development of Insulin-Producing and
Glucose-Regulating Cells in Drosophila


Sunday, January 30 | 8:00AM - 11:15AM
Diabetes and Obesity in Non-Mammalian Organisms (Joint)
Room: Longs/Quandary Peak

Speaker 3 of 7
Ernst Hafen, Institute of Molecular Systems Biology, ETH Zurich, Switzerland
Insulin Signaling and Growth Caontrol in D. melanogaster

Sunday, January 30 | 8:00AM - 11:15AM
Diabetes and Obesity in Non-Mammalian Organisms (Joint)
Room: Longs/Quandary Peak

Speaker 4 of 7
Wolfgang Driever, University of Freiburg, Germany
Genetic Analysis of Pancreas Development in Zebrafish

Sunday, January 30 | 8:00AM - 11:15AM
Diabetes and Obesity in Non-Mammalian Organisms (Joint)
Room: Longs/Quandary Peak

Speaker 5 of 7
Supriya Srinivasan, The Scripps Research Institute, USA
Short Talk: Defining the Serotonergic Circuit that Maintains Energy Homeostasis in C. elegans

Sunday, January 30 | 8:00AM - 11:15AM
Diabetes and Obesity in Non-Mammalian Organisms (Joint)
Room: Longs/Quandary Peak

Speaker 6 of 7
Lutz R. Kockel, Harvard Medical School, USA
Short Talk: Genome Wide Analysis of Akt Signaling by dsRNAi in Drosophila

Sunday, January 30 | 8:00AM - 11:15AM
Diabetes and Obesity in Non-Mammalian Organisms (Joint)
Room: Longs/Quandary Peak

Speaker 7 of 7
Sean M. Oldham, Takeda Pharmaceuticals International Co., USA
Short Talk: Regulation fo Insulin Producing Midgut Cells by P13K and Tor Signaling in Drosophila

Sunday, January 30 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Sunday, January 30 | 11:15AM - 1:00PM
Poster Setup
Room: Torreys Peak


Sunday, January 30 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys Peak


Sunday, January 30 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Sunday, January 30 | 5:00PM - 7:00PM
Intersections of Central Pathways Controlling Food Intake
Room: Quandary Peak

Speaker 1 of 5
* Malcolm J. Low, University of Michigan, USA

Sunday, January 30 | 5:00PM - 7:00PM
Intersections of Central Pathways Controlling Food Intake
Room: Quandary Peak

Speaker 2 of 5
Laurence H. Tecott, University of California, San Francisco, USA
Quantitative Behavioral Genetic Approaches to the Serotonergic Regulation of Energy Balance in the Mouse

Sunday, January 30 | 5:00PM - 7:00PM
Intersections of Central Pathways Controlling Food Intake
Room: Quandary Peak

Speaker 3 of 5
Randy J. Seeley, University of Michigan, USA
A Novel Role for the Cytokine GM-CSF in CNS Energy Balance Regulation

Sunday, January 30 | 5:00PM - 7:00PM
Intersections of Central Pathways Controlling Food Intake
Room: Quandary Peak

Speaker 4 of 5
Daniel L. Marks, Oregon Health & Science University, USA
Short Talk: Central Mechanisms in Cachexia

Sunday, January 30 | 5:00PM - 7:00PM
Intersections of Central Pathways Controlling Food Intake
Room: Quandary Peak

Speaker 5 of 5
Nina Balthasar, University of Bristol, UK
Short Talk: Melanocortin Action in the Paraventricular Hypothalamus

Sunday, January 30 | 5:00PM - 7:15PM
Signal Transduction
This session is from Diabetes Mellitus
Room: Longs Peak

Speaker 1 of 6
* Silvia Corvera, University of Massachusetts Medical School, USA


Sunday, January 30 | 5:00PM - 7:15PM
Signal Transduction
This session is from Diabetes Mellitus
Room: Longs Peak

Speaker 2 of 6
Stevan R. Hubbard, New York University School of Medicine, USA
Structural Basis for Recruitment of Adapter Proteins to the Activated Insulin Receptor


Sunday, January 30 | 5:00PM - 7:15PM
Signal Transduction
This session is from Diabetes Mellitus
Room: Longs Peak

Speaker 3 of 6
Marc R. Montminy, The Salk Institute for Biological Studies, USA
Regulation of Gluconeogenesis


Sunday, January 30 | 5:00PM - 7:15PM
Signal Transduction
This session is from Diabetes Mellitus
Room: Longs Peak

Speaker 4 of 6
George Thomas, University of Cincinnati, USA
The Role of S6K1 in the Pathogenesis of Obesity and the Development of Insulin Resistance


Sunday, January 30 | 5:00PM - 7:15PM
Signal Transduction
This session is from Diabetes Mellitus
Room: Longs Peak

Speaker 5 of 6
Gökhan S. Hotamisligil, Harvard School of Public Health, USA
Integration of Stress Signals in the Endoplasmic Reticulum in Obesity and Diabetes


Sunday, January 30 | 5:00PM - 7:15PM
Signal Transduction
This session is from Diabetes Mellitus
Room: Longs Peak

Speaker 6 of 6
Ji Yeon Lee, NIDDK, National Institutes of Health, USA
Short Talk: Talk: Deletion of the Transcription Factor Stat5 in Pancreatic ß-cell Disturbs Normal Glucose Homeostasis


Sunday, January 30 | 7:00PM - 8:00PM
Social Hour
Room: Longs Peak Foyer


Sunday, January 30 | 7:30PM - 10:00PM
Poster Session 3
Room: Torreys Peak


Monday, January 31 | 7:00AM - 8:00AM
Breakfast
Room: Grays Peak


Monday, January 31 | 8:00AM - 11:15AM
Genetics and Epigenetics of Diabetes and Obesity (Joint)
Room: Longs/Quandary Peak

Speaker 1 of 7
* Yoshihiro Ogawa, Kyushu University, Japan

Monday, January 31 | 8:00AM - 11:15AM
Genetics and Epigenetics of Diabetes and Obesity (Joint)
Room: Longs/Quandary Peak

Speaker 2 of 7
Doris A. Stoffers, Perelman School of Medicine, University of Pennsylvania, USA
Maturity Onset Diabetes of the Young (MODY): Human Monogenic Diabetes and Unraveling Genetic Transcriptional Networks of the ß Cell

Monday, January 31 | 8:00AM - 11:15AM
Genetics and Epigenetics of Diabetes and Obesity (Joint)
Room: Longs/Quandary Peak

Speaker 3 of 7
Sadaf Farooqi, University of Cambridge, UK
Insights from Monogenic Obesity Syndromes

Monday, January 31 | 8:00AM - 11:15AM
Genetics and Epigenetics of Diabetes and Obesity (Joint)
Room: Longs/Quandary Peak

Speaker 4 of 7
Gary A. Peltz, Standford University Medical Center, USA
From Mouse to Man: Understanding Disease

Monday, January 31 | 8:00AM - 11:15AM
Genetics and Epigenetics of Diabetes and Obesity (Joint)
Room: Longs/Quandary Peak

Speaker 5 of 7
Leonard P. Guarente, Massachusetts Institute of Technology, USA
SIRT1 Coordinates Fat Storage with Food Intake: Implications for Aging

Monday, January 31 | 8:00AM - 11:15AM
Genetics and Epigenetics of Diabetes and Obesity (Joint)
Room: Longs/Quandary Peak

Speaker 6 of 7
Chiao-Chien Connie Hung, Cambridge Institute for Medical Research, UK
Short Talk: A de novo Mutation in TrkB Associated with Severe Human Obesity and Developmental Delay

Monday, January 31 | 8:00AM - 11:15AM
Genetics and Epigenetics of Diabetes and Obesity (Joint)
Room: Longs/Quandary Peak

Speaker 7 of 7
Douglas R. Cavener, Pennsylvania State University, USA
Short Talk: Neonatal Proliferation of beta-cells is Critically Regulated by PERK (EIF2AK3)

Monday, January 31 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Monday, January 31 | 11:15AM - 1:00PM
Poster Setup
Room: Torreys Peak


Monday, January 31 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys Peak


Monday, January 31 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Monday, January 31 | 5:00PM - 7:30PM
Measures of Phenotypes Related to Energy Homeostasis in Anim
als and Humans

Room: Quandary Peak

Speaker 1 of 6
* Robert G. MacKenzie, Wayne State University, USA

Monday, January 31 | 5:00PM - 7:30PM
Measures of Phenotypes Related to Energy Homeostasis in Anim
als and Humans

Room: Quandary Peak

Speaker 2 of 6
Roger D. Cone, University of Michigan, USA
Actions of Gut Peptides on the Central Melanocortin System

Monday, January 31 | 5:00PM - 7:30PM
Measures of Phenotypes Related to Energy Homeostasis in Anim
als and Humans

Room: Quandary Peak

Speaker 3 of 6
Tamas L. Horvath, Yale School of Medicine, USA
Synaptic Plasticity in the Hypothalamus and Hippocampus: A Link Between Energy Balance and Cognition

Monday, January 31 | 5:00PM - 7:30PM
Measures of Phenotypes Related to Energy Homeostasis in Anim
als and Humans

Room: Quandary Peak

Speaker 4 of 6
Isabelle Bady, University of Lausanne, Switzerland
Short Talk: Central Glut2-Dependent Glucose Sensors Control Feeding and Energy Expenditure

Monday, January 31 | 5:00PM - 7:30PM
Measures of Phenotypes Related to Energy Homeostasis in Anim
als and Humans

Room: Quandary Peak

Speaker 5 of 6
Anand Mehta, KineMed, Inc., USA
Short Talk: Analysis of the Transcriptional Modulation of Metabolic Networks using GFP Reporters

Monday, January 31 | 5:00PM - 7:30PM
Measures of Phenotypes Related to Energy Homeostasis in Anim
als and Humans

Room: Quandary Peak

Speaker 6 of 6
Adam R. Kennedy, Cytokinetics Inc., USA
Short Talk: Decreased Body Weight and Increased Metabolism on a Very Low Carbohydrate Ketogenic Diet: The Effect of Diet Composition on Gene Expression and Cellular Metabolism

Monday, January 31 | 5:00PM - 7:00PM
Beta Cell Growth and Development
This session is from Diabetes Mellitus
Room: Longs Peak

Speaker 1 of 5
* Yoshitomo Oka, Tohoku University Graduate School of Medicine, Japan


Monday, January 31 | 5:00PM - 7:00PM
Beta Cell Growth and Development
This session is from Diabetes Mellitus
Room: Longs Peak

Speaker 2 of 5
Helena Edlund, Umeå University, Sweden
Molecular Mechanisms Controlling Generation and Maintenance of beta Cell Function


Monday, January 31 | 5:00PM - 7:00PM
Beta Cell Growth and Development
This session is from Diabetes Mellitus
Room: Longs Peak

Speaker 3 of 5
Klaus H. Kaestner, University of Pennsylvania School of Medicine, USA
Foxa Transcription Factors and the Beta Cell


Monday, January 31 | 5:00PM - 7:00PM
Beta Cell Growth and Development
This session is from Diabetes Mellitus
Room: Longs Peak

Speaker 4 of 5
Seung K. Kim, Stanford University, USA
Development of the Beta Cell


Monday, January 31 | 5:00PM - 7:00PM
Beta Cell Growth and Development
This session is from Diabetes Mellitus
Room: Longs Peak

Speaker 5 of 5
Beatriz Sosa-Pineda, Northwestern University Feinberg School of Medicine, USA
Short Talk: Pax4 is an Essential Regulator of Pancreatic beta-cell Development


Monday, January 31 | 7:00PM - 8:00PM
Social Hour
Room: Longs Peak Foyer


Monday, January 31 | 7:30PM - 10:00PM
Poster Session 4
Room: Torreys Peak


Tuesday, February 01 | 7:00AM - 8:00AM
Breakfast
Room: Grays Peak


Tuesday, February 01 | 8:00AM - 11:15AM
Nutrient Effects on Metabolism (Joint)
Room: Longs/Quandary Peak

Speaker 1 of 7
* Juleen R. Zierath, Karolinska Institutet, Sweden

Tuesday, February 01 | 8:00AM - 11:15AM
Nutrient Effects on Metabolism (Joint)
Room: Longs/Quandary Peak

Speaker 2 of 7
Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Novel Adipocyte-Secreted Protein Plays a Role in Insulin Resistance

Tuesday, February 01 | 8:00AM - 11:15AM
Nutrient Effects on Metabolism (Joint)
Room: Longs/Quandary Peak

Speaker 3 of 7
Nahum Sonenberg, McGill University, Canada
4E-BP Mediate Starvation and Oxidative Stress in Drosophilia and Effects on Obesity in Mice

Tuesday, February 01 | 8:00AM - 11:15AM
Nutrient Effects on Metabolism (Joint)
Room: Longs/Quandary Peak

Speaker 4 of 7
Takashi Kadowaki, University of Tokyo, Japan
Adiponectin Receptors and Metabolic Fuel Selection

Tuesday, February 01 | 8:00AM - 11:15AM
Nutrient Effects on Metabolism (Joint)
Room: Longs/Quandary Peak

Speaker 5 of 7
Domenico Accili, Columbia University, USA
Metabolic Regulation by Forkhead Proteins

Tuesday, February 01 | 8:00AM - 11:15AM
Nutrient Effects on Metabolism (Joint)
Room: Longs/Quandary Peak

Speaker 6 of 7
Nils Halberg, Rockefeller University, USA
Short Talk: The Effect of Intermittent Fasting on Insulin Sensitivity

Tuesday, February 01 | 8:00AM - 11:15AM
Nutrient Effects on Metabolism (Joint)
Room: Longs/Quandary Peak

Speaker 7 of 7
Bai Luo, University of Utah, USA
Short Talk: Cross-Talk Between Hexosamine Biosynthesis Pathway and AMP-Activated Protein Kinase in Adipocytes

Tuesday, February 01 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, February 01 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Tuesday, February 01 | 5:00PM - 7:00PM
Adipose Tissue Biology
Room: Quandary Peak

Speaker 1 of 5
* Susan K. Fried, Icahn School of Medicine at Mount Sinai, USA

Tuesday, February 01 | 5:00PM - 7:00PM
Adipose Tissue Biology
Room: Quandary Peak

Speaker 2 of 5
Jeffrey Flier, Harvard University, USA
SOCS3 and teh Genesis of Leptin and Insulin Resistance

Tuesday, February 01 | 5:00PM - 7:00PM
Adipose Tissue Biology
Room: Quandary Peak

Speaker 3 of 5
Anthony W. Ferrante, Columbia University, USA
Obesity and Adipose Tissue Macrophages

Tuesday, February 01 | 5:00PM - 7:00PM
Adipose Tissue Biology
Room: Quandary Peak

Speaker 4 of 5
Philipp E. Scherer, University of Texas Southwestern Medical Center, USA
Adiponectin and Resistin - Adipokines Modulating Insulin Signaling

Tuesday, February 01 | 5:00PM - 7:00PM
Adipose Tissue Biology
Room: Quandary Peak

Speaker 5 of 5
Anthony N. Hollenberg, Beth Israel Deaconess Medical Center, USA
Short Talk: The Role of Leptin and Melanocortin 4 - Receptor (MC4-R) Signaling in the Regulation of Thyrotropin-Releasing Hormone (TRH) Gene Expression

Tuesday, February 01 | 5:00PM - 7:00PM
Liver Development and Metabolism
This session is from Diabetes Mellitus
Room: Longs Peak

Speaker 1 of 5
* Rebecca A. Taub, VIA Pharmaceuticals, Inc, USA


Tuesday, February 01 | 5:00PM - 7:00PM
Liver Development and Metabolism
This session is from Diabetes Mellitus
Room: Longs Peak

Speaker 2 of 5
Christopher B. Newgard, Duke University Medical Center, USA
Metabolic Profiling Applied to Hepatic Regulatory Mechanisms


Tuesday, February 01 | 5:00PM - 7:00PM
Liver Development and Metabolism
This session is from Diabetes Mellitus
Room: Longs Peak

Speaker 3 of 5
Bernard Thorens, University of Lausanne, Switzerland
Multiple GLUT2-dependent Glucose Sensors


Tuesday, February 01 | 5:00PM - 7:00PM
Liver Development and Metabolism
This session is from Diabetes Mellitus
Room: Longs Peak

Speaker 4 of 5
Morris F. White, Boston Children's Hospital, Harvard Medical School, USA
Insulin Resistance and Dysregulated Nutrient Homeostasis


Tuesday, February 01 | 5:00PM - 7:00PM
Liver Development and Metabolism
This session is from Diabetes Mellitus
Room: Longs Peak

Speaker 5 of 5
Nancy A. Thornberry, Kallyope, Inc., USA
Short Talk: Dipeptidyl Peptidase IV (DPP-IV) Inhibition for Treatment of Type 2 DM: Potential Importance of Selective Inhibition and Discovery of MK-0431


Tuesday, February 01 | 7:00PM - 8:00PM
Social Hour
Room: Longs Peak Foyer


Tuesday, February 01 | 8:00PM - 11:00PM
Entertainment
Room: Grays Peak


Tuesday, February 01 | 8:00PM - 11:00PM
Cash Bar
Room: Longs Peak Foyer


Wednesday, February 02 | 10:26AM - 10:26AM
Departure


*Session Chair.