Web Desc
The Role of Microenvironment in Tumor Induction and Progression
joint with Cancer and Development
Organizer(s): Mina Bissell, Ronald DePinho and Luis Parada
Date: February 05 - 10, 2005
Location: Fairmont Banff Springs, Banff, AB, Canada
Sponsored by Abbott Laboratories
Summary of Meeting:
A shift has begun to take place in both the cancer research community and in funding agencies that support tumor biology as to the relative importance of microenvironmental control in differentiation and cancer. There is increased appreciation of the role of the microenvironment and 'context' in both normal tissue function and cancer initiation and progression. Indeed, NCI has initiated an 'extraordinary funding opportunity' program to extend its signatures of the cancer cell to its microenvironment (http://plan.cancer.gov/discovery/sigs.htm). An excerpt follows: 'Six years ago, NCI established 'Defining the Signatures of Cancer Cells'- Extraordinary Opportunity to promote research aimed at identifying and characterizing the full compendium of signature changes that occur within cancer cells. Now, as increasing evidence suggests that the host microenvironment plays a pivotal role in cancer development, we need to expand our effort to consider how the interaction of the cancer cell and microenvironment permits, and even encourages tumor development. Scientists pursuing this promising new scientific opportunity will read not only the signatures of cancer cells but also signatures of seemingly normal cells within the tumor microenvironment and signatures that reflect changes that occur as cancer cells interact with the host microenvironment.' Thus, thinking of both normal and cancer cells in context and as part of a larger structural entity is an area ripe for a sea of change. However, the general understanding and appreciation of the complexity and the extent of the microenvironment's influence on tissue function and dysfunction is limited, and at times simplistic. To move the field in this area so that thoughtful and significant research could be accomplished would require an in-depth dialogue between the vast majority of cell and molecular biologists who concentrate on the molecules and the cells and those who have worked in the context of the tissue and the host. Nevertheless, an interesting aspect of these developments is that before the advent and the excitement of molecular biology in the 70s and 80s, there was a considerable amount of important work in this area, which now could lend itself to mechanistic scrutiny. This body of work needs to be rediscovered, sorted, and built upon. The goal of this meeting is not only to bring together past and the present research in this field, but also point the way to where we need to go. We will bring together a number of experts who have done pioneering work in this complex area, and some of the new talents to the field, and showcase recent exciting developments and chart a map for accelerating future exploration and interactions. We need to capture more brilliant minds to enter this area. In this meeting, we propose to unravel the excitement and the promise of the field.
Discounted Abstract Deadline: October 5 2004
Discounted Registration Deadline: December 6 2004
We gratefully acknowledge additional support for this conference from:
Abbott LaboratoriesAVEO Pharmaceuticals, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer InstituteNCI
Grant No. 1R13-CA113258-01

National Nuclear Security AdministrationDOE/NNSA
Grant No. DE-FG02-05ER64025
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Saturday, February 05 | 3:00PM - 7:30PM
Registration
Room: Van Horne Foyer


Saturday, February 05 | 6:30PM - 7:30PM
Refreshments
Room: Van Horne Foyer


Saturday, February 05 | 7:30PM - 7:30PM
Introductory Remarks
Room: Van Horne Ballroom A/B

Speaker 1 of 2
Mina J. Bissell, Lawrence Berkeley National Laboratory, USA

Saturday, February 05 | 7:30PM - 7:30PM
Introductory Remarks
Room: Van Horne Ballroom A/B

Speaker 2 of 2
Suresh Mohla, NCI, National Institutes of Health, USA

Saturday, February 05 | 7:30PM - 9:30PM
Keynote Session: Development, Cancer, and the Microenvironme
nt (Joint)
Room: Van Horne Ballroom A/B

Speaker 1 of 2
Zena Werb, University of California, San Francisco, USA
Historical Perspective and What Development Tells Us about Cancer

Saturday, February 05 | 7:30PM - 9:30PM
Keynote Session: Development, Cancer, and the Microenvironme
nt (Joint)
Room: Van Horne Ballroom A/B

Speaker 2 of 2
Joan Massagué, Memorial Sloan Kettering Cancer Center, USA
Metastasis as a Developmental Problem

Sunday, February 06 | 7:00AM - 8:00AM
Breakfast
Room: Alberta/New Brunswick/Cascade


Sunday, February 06 | 8:00AM - 11:00AM
Angiogenesis and the Microenvironment
Room: Van Horne Ballroom A

Speaker 1 of 5
* Luisa Iruela-Arispe, University of California, Los Angeles, USA
Microenvironmental Regulation of Vascular Patterning

Sunday, February 06 | 8:00AM - 11:00AM
Angiogenesis and the Microenvironment
Room: Van Horne Ballroom A

Speaker 2 of 5
Nancy J. Boudreau, NCI, National Institutes of Health, USA
Co-Ordinate Loss of Hox D10 in Breast Tumor Progression and Angiogenesis; Bi-Directional Communication between Breast Tumor Epithelium and Angiogenic Stroma

Sunday, February 06 | 8:00AM - 11:00AM
Angiogenesis and the Microenvironment
Room: Van Horne Ballroom A

Speaker 3 of 5
Randall S. Johnson, University of Cambridge, UK
The Role of Endothelial Cell Hypoxic Response in Tumor Formation

Sunday, February 06 | 8:00AM - 11:00AM
Angiogenesis and the Microenvironment
Room: Van Horne Ballroom A

Speaker 4 of 5
Mary J.C. Hendrix, Children's Memorial Research Center at Northwestern University, USA
The Epigenetic Effect of the Metastatic Microenvironment on Tumor Cell Plasticity

Sunday, February 06 | 8:00AM - 11:00AM
Angiogenesis and the Microenvironment
Room: Van Horne Ballroom A

Speaker 5 of 5
Gavin O. Thurston, Regeneron Pharmaceuticals Inc., USA
Short Talk

Sunday, February 06 | 8:00AM - 11:00AM
Signal Transduction Pathways in Development and Cancer
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 1 of 5
* Mariann Bienz, MRC Laboratory of Molecular Biology, UK
Wnt Signaling and Dishevelled Function


Sunday, February 06 | 8:00AM - 11:00AM
Signal Transduction Pathways in Development and Cancer
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 2 of 5
Roeland Nusse, HHMI/Stanford University, USA
Wnt Signaling and Growth Control


Sunday, February 06 | 8:00AM - 11:00AM
Signal Transduction Pathways in Development and Cancer
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 3 of 5
Matthew P. Scott, Stanford University, USA
Development and Cancer of the Cerebellum


Sunday, February 06 | 8:00AM - 11:00AM
Signal Transduction Pathways in Development and Cancer
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 4 of 5
Matthias Hebrok, University of California, San Francisco, USA
Embryonic Signaling Pathways in Pancreatic Cancer


Sunday, February 06 | 8:00AM - 11:00AM
Signal Transduction Pathways in Development and Cancer
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 5 of 5
JoMichelle D. Corrales, Impact Communications, USA
Short Talk: Gli2 Mediates the Mitogenic Function of Sonic Hedgehog
in the Developing Mouse Cerebellum


Sunday, February 06 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Sunday, February 06 | 11:00AM - 1:00PM
Poster Setup
Room: Alberta/New Brunswick/Riverview


Sunday, February 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Alberta/New Brunswick/Riverview


Sunday, February 06 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Van Horne Foyer


Sunday, February 06 | 5:00PM - 7:00PM
Microenvironmental Influence on Metastasis
Room: Van Horne Ballroom A

Speaker 1 of 4
Jeffrey W. Pollard, Queen's Medical Research Institute, UK
Macrophages Promote Mammary Tumor Progression and Metastasis.

Sunday, February 06 | 5:00PM - 7:00PM
Microenvironmental Influence on Metastasis
Room: Van Horne Ballroom A

Speaker 2 of 4
Kenneth J. Pienta, Cue Biopharma, Inc., USA
Metastatic Cancer is a Heterogeneous Group of Diseases

Sunday, February 06 | 5:00PM - 7:00PM
Microenvironmental Influence on Metastasis
Room: Van Horne Ballroom A

Speaker 3 of 4
* Richard O. Hynes, Massachusetts Institute of Technology, USA
ECM Receptors and Metastasis

Sunday, February 06 | 5:00PM - 7:00PM
Microenvironmental Influence on Metastasis
Room: Van Horne Ballroom A

Speaker 4 of 4
Pepper Jo Schedin, Oregon Health & Science University, USA
Short Talk: Remodeling of the Mammary Tumor Microenvironment Following Pregnancy Promotes Tumor Cell Metastasis; a Plausible Mechanism for Poor Prognosis of Pregnancy-Associated Breast Cancer

Sunday, February 06 | 5:00PM - 7:00PM
Cell Cycle
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 1 of 4
* Iswar K. Hariharan, University of California, Berkeley, USA
Pathways that Regulate Growth and Cell Proliferation in Drosophila and Humans


Sunday, February 06 | 5:00PM - 7:00PM
Cell Cycle
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 2 of 4
Tian Xu, Yale University School of Medicine, USA
Deciphering Genetic Basis of Tumor Growth and Metastasis in Drosophila


Sunday, February 06 | 5:00PM - 7:00PM
Cell Cycle
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 3 of 4
Michael A. Dyer, HHMI/St. Jude Children's Research Hospital, USA
The Role of the Rb Family in Retinal Development and Retinoblastoma


Sunday, February 06 | 5:00PM - 7:00PM
Cell Cycle
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 4 of 4
Erica L. Jackson, University of California, San Francisco, USA
Short Talk: PDGF Signaling in Neural Stem Cells and Glioma Formation


Sunday, February 06 | 7:00PM - 8:00PM
Social Hour
Room: Alberta/New Brunswick/Riverview


Sunday, February 06 | 7:30PM - 10:00PM
Poster Session 1
Room: Alberta/New Brunswick/Riverview


Monday, February 07 | 7:00AM - 8:00AM
Breakfast
Room: Alberta/New Brunswick/Cascade


Monday, February 07 | 8:00AM - 11:00AM
Stromal-Epithelial and Heterotypic Interactions
Room: Van Horne Ballroom A

Speaker 1 of 5
* Harold L. Moses, Vanderbilt University, USA
Stromal and Epithelial TGF-ß Signaling in Carcinoma Initiation and Progression

Monday, February 07 | 8:00AM - 11:00AM
Stromal-Epithelial and Heterotypic Interactions
Room: Van Horne Ballroom A

Speaker 2 of 5
Mary Helen Barcellos-Hoff, New York School of Medicine, USA
Modulation of Mammary Stromal-Epithelial Interactions During Radiation Carcinogenesis

Monday, February 07 | 8:00AM - 11:00AM
Stromal-Epithelial and Heterotypic Interactions
Room: Van Horne Ballroom A

Speaker 3 of 5
Terry A. Van Dyke, National Cancer Institute, National Institutes of Health, USA
Selective Inactivation of P53 in Prostate Stroma in Response to Epithelial Tumorigenesis; Coevolution of Both Compartments During Tumor Progression

Monday, February 07 | 8:00AM - 11:00AM
Stromal-Epithelial and Heterotypic Interactions
Room: Van Horne Ballroom A

Speaker 4 of 5
Leland W.K. Chung, Emory University School of Medicine, USA
Stromal-Epithelial Interaction in Prostate Cancer Bone Metastasis

Monday, February 07 | 8:00AM - 11:00AM
Stromal-Epithelial and Heterotypic Interactions
Room: Van Horne Ballroom A

Speaker 5 of 5
Olivier De Wever, University of Ghent, Belgium
Short Talk: Implication of Stromal Myofibroblasts in Cancer Invasion

Monday, February 07 | 8:00AM - 11:00AM
Cancer Gene Functions
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 1 of 5
Dean Walton Felsher, Stanford University, USA
Conditional Transgenic Mouse Models of Oncogenesis in a Developmental Context


Monday, February 07 | 8:00AM - 11:00AM
Cancer Gene Functions
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 2 of 5
Charles J. Sherr, St. Jude Children's Research Hospital, USA
The Ink4a/Arf Tumor Suppressor Network


Monday, February 07 | 8:00AM - 11:00AM
Cancer Gene Functions
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 3 of 5
* Owen N. Witte, HHMI/University of California, Los Angeles, USA
Prostate Stem Cells and Prostate Cancer Development


Monday, February 07 | 8:00AM - 11:00AM
Cancer Gene Functions
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 4 of 5
Thomas Curran, Children's Hospital of Philadelphia, USA
Mouse Models and Molecular Targeted Therapies: Sonic Hedgehog Pathway Antagonist in Medulloblastoma


Monday, February 07 | 8:00AM - 11:00AM
Cancer Gene Functions
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 5 of 5
Robert B. Clarke, University of Manchester, UK
Short Talk: Isolation and Characterization of Human Mammary Stem Cells


Monday, February 07 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Monday, February 07 | 11:00AM - 1:00PM
Poster Setup
Room: Alberta/New Brunswick/Riverview


Monday, February 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Alberta/New Brunswick/Riverview


Monday, February 07 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Van Horne Foyer


Monday, February 07 | 5:00PM - 7:00PM
Recent Advances in Signaling in 3D Microenvironments
Room: Van Horne Ballroom A

Speaker 1 of 4
* Joan S. Brugge, Harvard Medical School, USA
Signaling Pathways in Morphogenesis and Apoptosis


Monday, February 07 | 5:00PM - 7:00PM
Recent Advances in Signaling in 3D Microenvironments
Room: Van Horne Ballroom A

Speaker 2 of 4
Valerie M. Weaver, University of California, San Francisco, USA
Tissue Polarity and the Mechanism of Epithelial Resistance to Chemotherapy

Monday, February 07 | 5:00PM - 7:00PM
Recent Advances in Signaling in 3D Microenvironments
Room: Van Horne Ballroom A

Speaker 3 of 4
Edna Cukierman, Fox Chase Cancer Center, USA
Primed Stroma 3D-Adhesions; Inciters of Tumor Permissiveness

Monday, February 07 | 5:00PM - 7:00PM
Recent Advances in Signaling in 3D Microenvironments
Room: Van Horne Ballroom A

Speaker 4 of 4
John L. Muschler, California Pacific Medical Center, USA
Short Talk: Loss of dystroglycan function alters responses to laminin-1 in carcinoma cells

Monday, February 07 | 5:00PM - 7:00PM
Cancer Origins
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 1 of 5
* Elizabeth H. Blackburn, University of California, San Francisco, USA
Distinct growth responses of human cancer cells to perturbing telomeres and telomerase


Monday, February 07 | 5:00PM - 7:00PM
Cancer Origins
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 2 of 5
Robert J. Coffey, Jr., Vanderbilt University Medical Center, USA
Identification of Developmentally Regulated Genes in Human Colorectal Cancer (CRC)


Monday, February 07 | 5:00PM - 7:00PM
Cancer Origins
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 3 of 5
Ling-Jie Kong, Merck Research Laboratories, USA
Short Talk: The Role of the Rb Family Protein p130 in Telomere Length Control


Monday, February 07 | 5:00PM - 7:00PM
Cancer Origins
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 4 of 5
Sumana Datta, Texas A & M University, USA
Short Talk: Brain Development and Prostate Cancer: From Flies to Humans


Monday, February 07 | 5:00PM - 7:00PM
Cancer Origins
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 5 of 5
Ellen E. McCarthy, Columbia University, USA
Short Talk: Bard1 and Mammary Tumorigenesis


Monday, February 07 | 7:00PM - 8:00PM
Social Hour
Room: Alberta/New Brunswick/Riverview


Monday, February 07 | 7:30PM - 10:00PM
Poster Session 2
Room: Alberta/New Brunswick/Riverview


Tuesday, February 08 | 7:00AM - 8:00AM
Breakfast
Room: Alberta/New Brunswick/Cascade


Tuesday, February 08 | 8:00AM - 11:00AM
Cancer Models (Joint)
Room: Van Horne Ballroom A/B

Speaker 1 of 5
* Ronald A. DePinho, University of Texas MD Anderson Cancer Center, USA
Genetics and Biology of Pancreas Cancer

Tuesday, February 08 | 8:00AM - 11:00AM
Cancer Models (Joint)
Room: Van Horne Ballroom A/B

Speaker 2 of 5
Elaine V. Fuchs, Rockefeller University, USA
Stem Cells and their Lineages in Skin

Tuesday, February 08 | 8:00AM - 11:00AM
Cancer Models (Joint)
Room: Van Horne Ballroom A/B

Speaker 3 of 5
Rudolf Jaenisch, Whitehead Institute for Biomedical Research, USA
Epigenetic Changes in Cancer and the Reversibility of the Malignant Phenotype

Tuesday, February 08 | 8:00AM - 11:00AM
Cancer Models (Joint)
Room: Van Horne Ballroom A/B

Speaker 4 of 5
Derek Radisky, Mayo Clinic, USA
Short Talk: MMP-3-Induced Malignancy in Mammary Epithelial Cells


Tuesday, February 08 | 8:00AM - 11:00AM
Cancer Models (Joint)
Room: Van Horne Ballroom A/B

Speaker 5 of 5
James F. Amatruda, University of Texas Southwestern Medical Center, USA
Short Talk: A Genetic Model of Testicular Cancer in the Zebrafish

Tuesday, February 08 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Tuesday, February 08 | 11:00AM - 1:00PM
Poster Setup
Room: Alberta/New Brunswick/Riverview


Tuesday, February 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Alberta/New Brunswick/Riverview


Tuesday, February 08 | 2:30PM - 4:30PM
Workshop: Cancer, Aging and the Microenvironment
Room: Van Horne Ballroom A

Speaker 1 of 5
* Judith Campisi, Buck Institute for Research on Aging, USA
Cancer and Aging: Role of the Senescent Microenvironment

Tuesday, February 08 | 2:30PM - 4:30PM
Workshop: Cancer, Aging and the Microenvironment
Room: Van Horne Ballroom A

Speaker 2 of 5
Irmgard Irminger-Finger, University of Geneva, Switzerland
Short Talk: Function of BARD1 in Tumor Suppression and Aging

Tuesday, February 08 | 2:30PM - 4:30PM
Workshop: Cancer, Aging and the Microenvironment
Room: Van Horne Ballroom A

Speaker 3 of 5
S. Ruby Chan, Washington University, USA
Short Talk: Characterization of Mammary Adenocarcinomas that Spontaneously Develop in Aged STAT1-Deficient Female Mice

Tuesday, February 08 | 2:30PM - 4:30PM
Workshop: Cancer, Aging and the Microenvironment
Room: Van Horne Ballroom A

Speaker 4 of 5
Babett Bartling, Martin Luther University, Germany
Short Talk: RAGE Diminishes the Proliferative Effect of Fibroblasts on Human Lung Cancer Cells

Tuesday, February 08 | 2:30PM - 4:30PM
Workshop: Cancer, Aging and the Microenvironment
Room: Van Horne Ballroom A

Speaker 5 of 5
Thea D. Tlsty, University of California, San Francisco, USA
Epigenetic and Genetic Changes Control Tumorigenic Phenotypes and Occur in vivo in Human Mammary Epithelia

Tuesday, February 08 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Van Horne Foyer


Tuesday, February 08 | 5:00PM - 7:00PM
The Extracellular Matrix and its Degrading Enzymes in Tumor
Progression and Metastasis

Room: Van Horne Ballroom A

Speaker 1 of 4
* Lynn M. Matrisian, Vanderbilt University School of Medicine, USA
MMPs in Cancer

Tuesday, February 08 | 5:00PM - 7:00PM
The Extracellular Matrix and its Degrading Enzymes in Tumor
Progression and Metastasis

Room: Van Horne Ballroom A

Speaker 2 of 4
Raghu Kalluri, University of Texas MD Anderson Cancer Center, USA
Extracellular Matrix Degradome Contributes to a Novel Class of Tumor Suppressors

Tuesday, February 08 | 5:00PM - 7:00PM
The Extracellular Matrix and its Degrading Enzymes in Tumor
Progression and Metastasis

Room: Van Horne Ballroom A

Speaker 3 of 4
Seth L. Schor, University of Dundee, UK
Migration Stimulating Factor (MSF): A Potent Bi-Directional Mediator of Tumor-Stromal Interactions

Tuesday, February 08 | 5:00PM - 7:00PM
The Extracellular Matrix and its Degrading Enzymes in Tumor
Progression and Metastasis

Room: Van Horne Ballroom A

Speaker 4 of 4
James P. Quigley, The Scripps Research Institute, USA
Short Talk: Janus Nature of Tumor Microenvironment: MMPs from the Stromal Face and the Tumor Face

Tuesday, February 08 | 5:00PM - 7:15PM
Signaling Pathways and Cancer
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 1 of 5
Philip A. Beachy, HHMI/Stanford University, USA
Hedgehog Signal Transduction


Tuesday, February 08 | 5:00PM - 7:15PM
Signaling Pathways and Cancer
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 2 of 5
* Hans C. Clevers, Hubrecht Institute, Netherlands
Beta-Catenin-TCF in Development and Cancer


Tuesday, February 08 | 5:00PM - 7:15PM
Signaling Pathways and Cancer
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 3 of 5
Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Oncogenesis and Developmental Control


Tuesday, February 08 | 5:00PM - 7:15PM
Signaling Pathways and Cancer
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 4 of 5
Lee L. Rubin, Harvard University, USA
The Hedgehog Signaling Pathway and Cancer: Therapeutic Use of Small Molecule Antagonists


Tuesday, February 08 | 5:00PM - 7:15PM
Signaling Pathways and Cancer
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 5 of 5
Robert J. Wechsler-Reya, Sanford-Burnham Medical Research Institute, USA
Short Talk: Molecular and Cellular Origins of Medulloblastoma


Tuesday, February 08 | 7:15PM - 8:15PM
Social Hour
Room: Alberta/New Brunswick/Riverview


Tuesday, February 08 | 7:30PM - 10:00PM
Poster Session 3
Room: Alberta/New Brunswick/Riverview


Wednesday, February 09 | 7:00AM - 8:00AM
Breakfast
Room: Alberta/New Brunswick/Cascade


Wednesday, February 09 | 8:00AM - 11:00AM
Role of Inflammatory Cells and Cytokines in the Tissue and T
umor Microenvironment

Room: Van Horne Ballroom A

Speaker 1 of 5
* Luis F. Parada, Memorial Sloan Kettering Cancer Center, USA
Mast Cells and Tumor Induction Models

Wednesday, February 09 | 8:00AM - 11:00AM
Role of Inflammatory Cells and Cytokines in the Tissue and T
umor Microenvironment

Room: Van Horne Ballroom A

Speaker 2 of 5
Douglas Hanahan, ISREC, Switzerland
Immune Enhancement and Therapy of Cancer

Wednesday, February 09 | 8:00AM - 11:00AM
Role of Inflammatory Cells and Cytokines in the Tissue and T
umor Microenvironment

Room: Van Horne Ballroom A

Speaker 3 of 5
Lisa M. Coussens, Oregon Health & Science University, USA
Innate and Adaptive Immune Interactions Regulate Cancer Development

Wednesday, February 09 | 8:00AM - 11:00AM
Role of Inflammatory Cells and Cytokines in the Tissue and T
umor Microenvironment

Room: Van Horne Ballroom A

Speaker 4 of 5
Kornelia Polyak, Dana-Farber Cancer Institute, Harvard Medical School, USA
Molecular Profile of the Tumor Microenvironment in Breast Cancer

Wednesday, February 09 | 8:00AM - 11:00AM
Role of Inflammatory Cells and Cytokines in the Tissue and T
umor Microenvironment

Room: Van Horne Ballroom A

Speaker 5 of 5
Julia L. Wilson, UK
Short Talk: Expression of the Chemokine Receptor CXCR4 Alters the Behavior of Ovarian Cancer Cells in vitro and in vivo

Wednesday, February 09 | 8:00AM - 11:00AM
Growth Control
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 1 of 5
Max S. Wicha, University of Michigan, USA
Stem Cells in Human Human Breast Development and Cancer


Wednesday, February 09 | 8:00AM - 11:00AM
Growth Control
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 2 of 5
Gary B. Ruvkun, Massachusetts General Hospital, Harvard Medical School, USA
Growth Control in C. elegans


Wednesday, February 09 | 8:00AM - 11:00AM
Growth Control
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 3 of 5
* Anton J. M. Berns, Netherlands Cancer Institute, Netherlands
Mouse Models for Cancer


Wednesday, February 09 | 8:00AM - 11:00AM
Growth Control
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 4 of 5
Thomas Thomas Look, Dana-Farber Cancer Institute, USA
Genetics of T-Cell Acute Lymphoblastic Leukemia: The Role of Notch


Wednesday, February 09 | 8:00AM - 11:00AM
Growth Control
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 5 of 5
Johannes L. Bos, University Medical Center Utrecht, Netherlands
Short Talk: Genetic Mapping of Notch1 Activity in vivo


Wednesday, February 09 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Foyer


Wednesday, February 09 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Van Horne Foyer


Wednesday, February 09 | 5:00PM - 7:00PM
Concluding Session
Room: Van Horne Ballroom A

Speaker 1 of 2
M. Judah Folkman, Children's Hospital Boston, USA
How Early Can Cancer be Treated?

Wednesday, February 09 | 5:00PM - 7:00PM
Concluding Session
Room: Van Horne Ballroom A

Speaker 2 of 2
Mina J. Bissell, Lawrence Berkeley National Laboratory, USA
Summary of the Meeting: Looking to the Future

Wednesday, February 09 | 5:00PM - 7:00PM
Checkpoints and Signal Transduction
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 1 of 4
Anindya Dutta, University of Virginia, USA
Checkpoint Pathways Monitor Levels of Replication Initiators in Cancer Cells


Wednesday, February 09 | 5:00PM - 7:00PM
Checkpoints and Signal Transduction
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 2 of 4
* Garry P. Nolan, Stanford University, USA
Single Cell Proteomics of Cancer: Remodeling of Networks on a Patient by Patient Basis


Wednesday, February 09 | 5:00PM - 7:00PM
Checkpoints and Signal Transduction
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 3 of 4
Esther M. Verheyen, Simon Fraser University, Canada
Short Talk: Control of Wnt and BMP Signaling by the Nemo-like Kinase during Drosophila Development


Wednesday, February 09 | 5:00PM - 7:00PM
Checkpoints and Signal Transduction
This session is from Cancer and Development
Room: Van Horne Ballroom B

Speaker 4 of 4
Johannes L. Bos, University Medical Center Utrecht, Netherlands
Short Talk: The Small GTPase Rap1, the cAMP Target Epac and Integrin- and Cadherin-Mediated Cell Adhesion


Wednesday, February 09 | 7:00PM - 8:00PM
Social Hour
Room: Cascade/Conservatory/Riverview


Wednesday, February 09 | 8:00PM - 11:00PM
Entertainment
Room: Cascade/Conservatory/Riverview


Wednesday, February 09 | 8:00PM - 11:00PM
Cash Bar
Room: Cascade/Conservatory/Riverview


Thursday, February 10 | 10:26AM - 10:26AM
Departure


*Session Chair.