Web Desc
Cellular Senescence and Cell Death
joint with Survival and Death in Immune Tolerance and Homeostasis
Organizer(s): Douglas R. Green, Scott W. Lowe and Jacqueline A. Lees
Date: March 03 - 09, 2005
Location: Keystone Resort, Keystone, CO, USA
Supported by The Director's Fund
Summary of Meeting:
When we consider the enormous number of cells that proliferate in an individual over the course of a lifetime, cancer is a remarkably rare occurrence. Two major and general checks on carcinogenesis are the processes of cellular senescence and apoptosis. Although these appear to be fundamentally different in their final outcome, both processes have a number of similarities. The elucidation of nature and mechanisms of these similarities are a major goal of this meeting. Both apoptosis and senescence are irreversible after a point of no return, and function as anti-tumor mechanisms that can be disrupted as part of oncogenesis. Many of the upstream inducers and regulators are common to both, and stressors that trigger apoptosis in one cell type will induce senescence in another. These include telomere malfunction, oncogene activation, and DNA damage. The regulation of senescence and apoptosis are affected by common signaling pathways, including p53, PI3-kinase and AKT, stress-induced kinase pathways, and nuclear factor-kappaB. In addition to roles in checking cancer, or perhaps as a consequence of these roles, apoptosis and senescence contribute to aging. The goal of this meeting is to bring together experts in apoptosis, senescence, and oncogenic transformation in order to explore the similarities and differences in these processes. The interconnections between these biological events and the overlapping principles that emerge represent an emerging field in biology and biomedical research.
Discounted Abstract Deadline: November 3 2004
Discounted Registration Deadline: January 3 2005
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.EMD Biosciences, Inc.Genentech, Inc.IDUN Pharmaceuticals, Inc.
Merck Research Laboratories
Novartis Institutes for BioMedical ResearchPioneer Hi-Bred a DuPont business
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Maxim Pharmaceuticals, Inc.

Merck Research Laboratories
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1R13-CA112922-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, March 03 | 3:00PM - 7:30PM
Registration
Room: Grays Peak Foyer


Thursday, March 03 | 6:30PM - 7:30PM
Refreshments
Room: Longs Peak Foyer


Thursday, March 03 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Grays/Longs Peak

Speaker 2 of 2
Michael Karin, University of California, San Diego, USA
The IkappaB Kinase (IKK) and the Control of Immunity, Inflammation and Cancer


Thursday, March 03 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Grays/Longs Peak

Speaker 1 of 2
Robert A. Weinberg, Massachusetts Institute of Technology, USA
Human Cell Transformation

Friday, March 04 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Friday, March 04 | 8:00AM - 11:15AM
Cellular Immortalization and Transformation
Room: Longs Peak

Speaker 2 of 6
René Bernards, Netherlands Cancer Institute, Netherlands
High Throughput RNAi Screens to Identify Novel Components of the Cellular Senescence Response

Friday, March 04 | 8:00AM - 11:15AM
Cellular Immortalization and Transformation
Room: Longs Peak

Speaker 1 of 6
* Charles J. Sherr, St. Jude Children's Research Hospital, USA
The Ink4a/Arf Tumor Suppressor Network

Friday, March 04 | 8:00AM - 11:15AM
Cellular Immortalization and Transformation
Room: Longs Peak

Speaker 3 of 6
Moshe Oren, Weizmann Institute of Science, Israel
Mutant p53 Gain of Function: Inhibition of Apoptosis through Modulation of Gene Eexpression

Friday, March 04 | 8:00AM - 11:15AM
Cellular Immortalization and Transformation
Room: Longs Peak

Speaker 4 of 6
Karen H. Vousden, Francis Crick Institute, UK
Cell Death or Survival in Response to p53

Friday, March 04 | 8:00AM - 11:15AM
Cellular Immortalization and Transformation
Room: Longs Peak

Speaker 5 of 6
Daniel S. Peeper, Netherlands Cancer Institute, Netherlands
Short Talk: Oncogene-Induced Senescence: in vitto Tool or in vivo Reality

Friday, March 04 | 8:00AM - 11:15AM
Cellular Immortalization and Transformation
Room: Longs Peak

Speaker 6 of 6
Michael Andreeff, University of Texas MD Anderson Cancer Center, USA
Short Talk: Inhibition of p53-MDM2 Interaction by Small-Molecule Antagonist of MDM2 Effectively Induces Apoptosis in Leukemias

Friday, March 04 | 8:00AM - 11:00AM
Death and Differentiation
This session is from Immune Tolerance
Room: Grays Peak

Speaker 1 of 4
* Kristin A. Hogquist, University of Minnesota, USA
The Timing of TCRalpha Chain Expression is Critical for Proper T Cell Development


Friday, March 04 | 8:00AM - 11:00AM
Death and Differentiation
This session is from Immune Tolerance
Room: Grays Peak

Speaker 2 of 4
Juan Carlos Zúñiga-Pflücker, Sunnybrook Research Institute, Canada
Survival during T Cell Differentiation


Friday, March 04 | 8:00AM - 11:00AM
Death and Differentiation
This session is from Immune Tolerance
Room: Grays Peak

Speaker 3 of 4
Ed Palmer, University of Basel Hospital, Switzerland
TCR Signaling and T Cell Fate


Friday, March 04 | 8:00AM - 11:00AM
Death and Differentiation
This session is from Immune Tolerance
Room: Grays Peak

Speaker 4 of 4
Matthew L. Albert, Genentech, Inc., USA
Death and Immunity


Friday, March 04 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Friday, March 04 | 11:00AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Friday, March 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Friday, March 04 | 2:00PM - 4:00PM
Workshop 1: Apoptosis and Self-Tolerance
This session is from Immune Tolerance
Room: Grays Peak

Speaker 1 of 11
* Philippa C. Marrack, HHMI/National Jewish Health, USA


Friday, March 04 | 2:00PM - 4:00PM
Workshop 1: Apoptosis and Self-Tolerance
This session is from Immune Tolerance
Room: Grays Peak

Speaker 2 of 11
Nami McCarty, University of Texas Health Science Center, USA
Signaling by MINK Plays an Important Role in Negative Selection of Autoreactive Thymocytes


Friday, March 04 | 2:00PM - 4:00PM
Workshop 1: Apoptosis and Self-Tolerance
This session is from Immune Tolerance
Room: Grays Peak

Speaker 3 of 11
Yina H. Huang, Dartmouth College, USA
An Essential Role for Ins(1,4,5)P3 3-Kinase B in TCR Signals Leading to Thymocyte Positive Selection


Friday, March 04 | 2:00PM - 4:00PM
Workshop 1: Apoptosis and Self-Tolerance
This session is from Immune Tolerance
Room: Grays Peak

Speaker 4 of 11
Ruan Zhang, Transplant Institute, USA
The Role of E3 Ubiquitin Ligase Cbl-b in Murine CD4+ T Cells Anergy Induction


Friday, March 04 | 2:00PM - 4:00PM
Workshop 1: Apoptosis and Self-Tolerance
This session is from Immune Tolerance
Room: Grays Peak

Speaker 5 of 11
Paula M. Oliver, University of Pennsylvania, USA
Loss of Bim Breaks B Cell Anergy


Friday, March 04 | 2:00PM - 4:00PM
Workshop 1: Apoptosis and Self-Tolerance
This session is from Immune Tolerance
Room: Grays Peak

Speaker 6 of 11
Patrick T. Walsh, University of Pennsylvania, USA
PTEN Regulates the Response of CD4+CD25+ Regulatory T Cells to IL-2 Receptor Stimulation


Friday, March 04 | 2:00PM - 4:00PM
Workshop 1: Apoptosis and Self-Tolerance
This session is from Immune Tolerance
Room: Grays Peak

Speaker 7 of 11
Keiji Hirota, Kyoto University, Japan
Generation of Autoaggressive CD4+ T Cells due to a ZAP-70 Point Mutation in SKG Mice that Spontaneously Develop Autoimmune Arthritis


Friday, March 04 | 2:00PM - 4:00PM
Workshop 1: Apoptosis and Self-Tolerance
This session is from Immune Tolerance
Room: Grays Peak

Speaker 8 of 11
Bin Li, Shanghai Institute of Immunology, China
FOXP3-Mediated Transcriptional Repression is Regulated by Histone Acetylase-Deacetylase Complex


Friday, March 04 | 2:00PM - 4:00PM
Workshop 1: Apoptosis and Self-Tolerance
This session is from Immune Tolerance
Room: Grays Peak

Speaker 9 of 11
Thomas A. Ferguson, Washington University School of Medicine, USA
Apoptosis and Tolerance: The Role of Caspase-Induced Mitochondrial Disruption


Friday, March 04 | 2:00PM - 4:00PM
Workshop 1: Apoptosis and Self-Tolerance
This session is from Immune Tolerance
Room: Grays Peak

Speaker 10 of 11
Mats V. H. Karlberg, Karolinska Institutet, Sweden
Expression of the Pro-Survival Gene A1 in Mast Cells is Transcriptionally Regulated by NFAT


Friday, March 04 | 2:00PM - 4:00PM
Workshop 1: Apoptosis and Self-Tolerance
This session is from Immune Tolerance
Room: Grays Peak

Speaker 11 of 11
Eric S. Huseby, University of Massachusetts Medical School, USA
How the T Cell Repertoire Becomes Peptide and MHC Specific


Friday, March 04 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Friday, March 04 | 5:00PM - 7:00PM
Coupling Proliferation to Antiproliferation
Room: Longs Peak

Speaker 1 of 5
* Thea D. Tlsty, University of California, San Francisco, USA

Friday, March 04 | 5:00PM - 7:00PM
Coupling Proliferation to Antiproliferation
Room: Longs Peak

Speaker 2 of 5
Joseph R. Nevins, Duke University Medical Center, USA
Molecular Mechanisms Linking the Control of Cell Proliferation with Cell Fate Determination

Friday, March 04 | 5:00PM - 7:00PM
Coupling Proliferation to Antiproliferation
Room: Longs Peak

Speaker 3 of 5
Loren D. Walensky, Dana-Farber Cancer Institute, USA
Targeting Apoptosis in Vivo Using Chemically-Stabilized Helices of the BCL-2 Family

Friday, March 04 | 5:00PM - 7:00PM
Coupling Proliferation to Antiproliferation
Room: Longs Peak

Speaker 4 of 5
Jacqueline A. Lees, Massachusetts Institute of Technology, USA

Friday, March 04 | 5:00PM - 7:00PM
Coupling Proliferation to Antiproliferation
Room: Longs Peak

Speaker 5 of 5
Navdeep S. Chandel, Northwestern University, USA
Short Talk: Hypoxia Increases Oxidative Stress and Replicative Lifespan

Friday, March 04 | 5:00PM - 7:00PM
Peripheral Tolerance and Apoptosis
This session is from Immune Tolerance
Room: Grays Peak

Speaker 1 of 4
* Philippa C. Marrack, HHMI/National Jewish Health, USA
Controlling Death in the Immune System


Friday, March 04 | 5:00PM - 7:00PM
Peripheral Tolerance and Apoptosis
This session is from Immune Tolerance
Room: Grays Peak

Speaker 2 of 4
Pamela S. Ohashi, Princess Margaret Cancer Centre, Canada
Molecules that Regulate T Cell Tolerance and Survival


Friday, March 04 | 5:00PM - 7:00PM
Peripheral Tolerance and Apoptosis
This session is from Immune Tolerance
Room: Grays Peak

Speaker 3 of 4
Yun-Cai Liu, La Jolla Institute for Allergy and Immunology, USA
Short Talk: E3 Ligases Regulate T Cell Activation and Survival


Friday, March 04 | 5:00PM - 7:00PM
Peripheral Tolerance and Apoptosis
This session is from Immune Tolerance
Room: Grays Peak

Speaker 4 of 4
Evan F. Lind, Oregon Health and Science University, USA
Short Talk: The Role of NF-kappaB Inducing Kinase in Dendritic Cell Function and Tolerance


Friday, March 04 | 7:00PM - 8:00PM
Social Hour
Room: Shavano/Torreys


Friday, March 04 | 7:30PM - 10:00PM
Poster Session 1
Room: Shavano/Torreys


Saturday, March 05 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Saturday, March 05 | 8:00AM - 11:15AM
Cellular Sensors and Effectors
Room: Longs Peak

Speaker 1 of 7
* Shailaja Kasibhatla, Maxim Pharmaceuticals Inc., USA

Saturday, March 05 | 8:00AM - 11:15AM
Cellular Sensors and Effectors
Room: Longs Peak

Speaker 2 of 7
Steven J. Weintraub, Washington University, USA
Bcl-xL Deamidation and Rb in the DNA Damage Response

Saturday, March 05 | 8:00AM - 11:15AM
Cellular Sensors and Effectors
Room: Longs Peak

Speaker 3 of 7
Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Is Cellular Senescence Resistant to Tumorigenesis in vivo?

Saturday, March 05 | 8:00AM - 11:15AM
Cellular Sensors and Effectors
Room: Longs Peak

Speaker 4 of 7
Gerry Melino, University of Rome ‘Tor Vergata’, Italy
Function of P63 (P53 Family) in Cell Death

Saturday, March 05 | 8:00AM - 11:15AM
Cellular Sensors and Effectors
Room: Longs Peak

Speaker 5 of 7
Seamus J. Martin, Trinity College Dublin, Ireland
Understanding NK/GL Cell-Mediated Cytotocicity through Defining the Granzyme Degradome

Saturday, March 05 | 8:00AM - 11:15AM
Cellular Sensors and Effectors
Room: Longs Peak

Speaker 6 of 7
Fabrizio d'Adda di Fagagna, IFOM, The FIRC Institute of Molecular Oncology, Italy
Short Talk: Short Talk: The Role of DNA-Damage Response Factors in the Establishment of Cellular Senescence

Saturday, March 05 | 8:00AM - 11:15AM
Cellular Sensors and Effectors
Room: Longs Peak

Speaker 7 of 7
Colin S. Duckett, University of Michigan, USA
Short Talk: Altered Properties of XIAP in Copper Toxicosis Diseases

Saturday, March 05 | 8:00AM - 11:00AM
Survival during Effector Cell Generation
This session is from Immune Tolerance
Room: Grays Peak

Speaker 1 of 5
* Michael Croft, La Jolla Institute for Immunology, USA
Costimulation and T Cell Survival


Saturday, March 05 | 8:00AM - 11:00AM
Survival during Effector Cell Generation
This session is from Immune Tolerance
Room: Grays Peak

Speaker 2 of 5
Hao Wu, Harvard Medical School, Boston Children's Hospital, USA
XIAP, Caspases, Smac, TAB1 and p35: Old Molecules with New Twists


Saturday, March 05 | 8:00AM - 11:00AM
Survival during Effector Cell Generation
This session is from Immune Tolerance
Room: Grays Peak

Speaker 3 of 5
Razq Hakem, University Health Network, Canada
Caspase 8 And Cell Activation


Saturday, March 05 | 8:00AM - 11:00AM
Survival during Effector Cell Generation
This session is from Immune Tolerance
Room: Grays Peak

Speaker 4 of 5
Chie Watanabe, University of Washington, USA
Short Talk: Caspase-6 Regulates G0 to G1 Entry into the Cell Cycle and Activation in Lymphocytes


Saturday, March 05 | 8:00AM - 11:00AM
Survival during Effector Cell Generation
This session is from Immune Tolerance
Room: Grays Peak

Speaker 5 of 5
Nicolas Bidère, INSERM, France
Short Talk: Requirement for Caspase-8 in NF-kB Activation by Antigen Receptor


Saturday, March 05 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Saturday, March 05 | 11:00AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Saturday, March 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Saturday, March 05 | 2:00PM - 4:00PM
Workshop 2: Survival and Death Pathways in Immune Cell Devel
opment
This session is from Immune Tolerance
Room: Grays Peak

Speaker 1 of 10
* Henning Walczak, University College London, Cancer Institute, UK


Saturday, March 05 | 2:00PM - 4:00PM
Workshop 2: Survival and Death Pathways in Immune Cell Devel
opment
This session is from Immune Tolerance
Room: Grays Peak

Speaker 2 of 10
Hien N. Chau, Advanced Medical Discovery Institute, Canada
Cellular FLICE-Inhibitory Protein (cFLIP) is Required for T Cell Survival and Cycling


Saturday, March 05 | 2:00PM - 4:00PM
Workshop 2: Survival and Death Pathways in Immune Cell Devel
opment
This session is from Immune Tolerance
Room: Grays Peak

Speaker 3 of 10
You-Wen He, Duke University Medical Center, USA
Development of Mature T Lymphocytes Requires cFLIP


Saturday, March 05 | 2:00PM - 4:00PM
Workshop 2: Survival and Death Pathways in Immune Cell Devel
opment
This session is from Immune Tolerance
Room: Grays Peak

Speaker 4 of 10
Dirk Brenner, Luxembourg Institute of Health, Luxembourg
Sensitization of Primary T-Cells towards Aicd by Suppression of NFkB can be Mediated Through Hematopoietic Progenitor Kinase 1 (HPK1)


Saturday, March 05 | 2:00PM - 4:00PM
Workshop 2: Survival and Death Pathways in Immune Cell Devel
opment
This session is from Immune Tolerance
Room: Grays Peak

Speaker 5 of 10
Andrew Craxton, University of Washington, USA
Regulation of B Lymphocyte Survival by BAFF-induced downregulation of the BH3-only Bcl-2 homolog Bim


Saturday, March 05 | 2:00PM - 4:00PM
Workshop 2: Survival and Death Pathways in Immune Cell Devel
opment
This session is from Immune Tolerance
Room: Grays Peak

Speaker 6 of 10
Kyeong-Hee Lee, Genentech, Inc., USA
Subcellular Localization of Fas Signaling Controls FasL Activated Cellular Fates


Saturday, March 05 | 2:00PM - 4:00PM
Workshop 2: Survival and Death Pathways in Immune Cell Devel
opment
This session is from Immune Tolerance
Room: Grays Peak

Speaker 7 of 10
Masayuki Noguchi, Hokkaido University, Japan
Akt-in, A Peptide Inhibitor that Blocks AKT kinase Activation


Saturday, March 05 | 2:00PM - 4:00PM
Workshop 2: Survival and Death Pathways in Immune Cell Devel
opment
This session is from Immune Tolerance
Room: Grays Peak

Speaker 8 of 10
John J. Priatel, University of British Columbia, Canada
RasGRP1 Translates T Cell Receptor Signaling into CD4/CD8 Lineage Decision and Cellular Survival Cues


Saturday, March 05 | 2:00PM - 4:00PM
Workshop 2: Survival and Death Pathways in Immune Cell Devel
opment
This session is from Immune Tolerance
Room: Grays Peak

Speaker 9 of 10
Jerold G. Woodward, University of Kentucky Medical Center, USA
HSF-1 is Critical for T Cell Function at Fever Temperatures


Saturday, March 05 | 2:00PM - 4:00PM
Workshop 2: Survival and Death Pathways in Immune Cell Devel
opment
This session is from Immune Tolerance
Room: Grays Peak

Speaker 10 of 10
Maya Saleh, McGill University, Canada
Caspase-12 in NF-kB Regulation and Sepsis


Saturday, March 05 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Saturday, March 05 | 5:00PM - 7:00PM
Apoptosis and Senescence in Aging, Degeneration, and Cancer
Room: Longs Peak

Speaker 1 of 5
* Jacqueline A. Lees, Massachusetts Institute of Technology, USA

Saturday, March 05 | 5:00PM - 7:00PM
Apoptosis and Senescence in Aging, Degeneration, and Cancer
Room: Longs Peak

Speaker 2 of 5
Jan H. J. Hoeijmakers, Erasmus MC, Netherlands
The DNA Damage Problem and its Impact on Cancer and Ageing

Saturday, March 05 | 5:00PM - 7:00PM
Apoptosis and Senescence in Aging, Degeneration, and Cancer
Room: Longs Peak

Speaker 3 of 5
Junying Yuan, Harvard Medical School, USA
PTEN Deficiency Activates Distint Downstream Signaling Pathways in a Tissue Specific Manner

Saturday, March 05 | 5:00PM - 7:00PM
Apoptosis and Senescence in Aging, Degeneration, and Cancer
Room: Longs Peak

Speaker 4 of 5
Judith Campisi, Buck Institute for Research on Aging, USA
Tumor Suppression, Aging and Cellular Senescence


Saturday, March 05 | 5:00PM - 7:00PM
Apoptosis and Senescence in Aging, Degeneration, and Cancer
Room: Longs Peak

Speaker 5 of 5
Philippe A. Parone, University of Geneva, Switzerland
Short Talk: Mitochondrial Fission is Required for Cell Cycle Progression but is not Essential for Apoptosis

Saturday, March 05 | 5:00PM - 7:00PM
Crosstalk between Life and Death Signaling
This session is from Immune Tolerance
Room: Grays Peak

Speaker 1 of 3
* Jürg Tschopp, University of Lausanne, Switzerland
Dissecting Signaling Cascades from Death Receptors


Saturday, March 05 | 5:00PM - 7:00PM
Crosstalk between Life and Death Signaling
This session is from Immune Tolerance
Room: Grays Peak

Speaker 2 of 3
Richard M. Siegel, NIAMS, National Institutes of Health, USA
Life and Death Decisions in TLR and TNF Family Receptor Signaling


Saturday, March 05 | 5:00PM - 7:00PM
Crosstalk between Life and Death Signaling
This session is from Immune Tolerance
Room: Grays Peak

Speaker 3 of 3
Yongwon Choi, University of Pennsylvania, USA
TRAF6 and Autoimmunity


Saturday, March 05 | 7:00PM - 8:00PM
Social Hour
Room: Shavano/Torreys


Saturday, March 05 | 7:30PM - 10:00PM
Poster Session 2
Room: Shavano/Torreys


Sunday, March 06 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Sunday, March 06 | 8:00AM - 11:00AM
Signaling in Cell Death and Survival (Joint)
Room: Grays/Longs Peak

Speaker 1 of 4
* Gerard I. Evan, University of Cambridge, UK
Suppression of Apoptosis in Tumor Maintenance

Sunday, March 06 | 8:00AM - 11:00AM
Signaling in Cell Death and Survival (Joint)
Room: Grays/Longs Peak

Speaker 2 of 4
Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Calcium: an GR Metaphor of Cell Survival/Death

Sunday, March 06 | 8:00AM - 11:00AM
Signaling in Cell Death and Survival (Joint)
Room: Grays/Longs Peak

Speaker 3 of 4
John C. Reed, Sanofi, France
IAP-Family Proteins: Dual Roles in Cell Death and Division

Sunday, March 06 | 8:00AM - 11:00AM
Signaling in Cell Death and Survival (Joint)
Room: Grays/Longs Peak

Speaker 4 of 4
Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada
Unfinished Business

Sunday, March 06 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Sunday, March 06 | 11:00AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Sunday, March 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Sunday, March 06 | 2:00PM - 4:00PM
Workshop 3: Immune Homeostasis
This session is from Immune Tolerance
Room: Grays Peak

Speaker 1 of 9
* Leo Lefrançois, University of Connecticut Health Center, USA


Sunday, March 06 | 2:00PM - 4:00PM
Workshop 3: Immune Homeostasis
This session is from Immune Tolerance
Room: Grays Peak

Speaker 2 of 9
C. John Luckey, Brigham and Women's Hospital, USA
Identification of a Transcriptional Profile Shared between Self-Renewing Populations of Memory CD8+ T Cells and Long-Term Hematopoietic Stem Cells


Sunday, March 06 | 2:00PM - 4:00PM
Workshop 3: Immune Homeostasis
This session is from Immune Tolerance
Room: Grays Peak

Speaker 3 of 9
Jodie S. Haring, University of Iowa, USA
Dynamic Regulation of IFN-gamma Responsiveness in Antigen-Specific CD8 T Cells Following Infection


Sunday, March 06 | 2:00PM - 4:00PM
Workshop 3: Immune Homeostasis
This session is from Immune Tolerance
Room: Grays Peak

Speaker 4 of 9
Hans Dooms, Boston University, USA
Regulation of IL-2 and IL-7 Receptors in the Life of a T Cell


Sunday, March 06 | 2:00PM - 4:00PM
Workshop 3: Immune Homeostasis
This session is from Immune Tolerance
Room: Grays Peak

Speaker 5 of 9
Karen A. Fortner, University of Vermont, USA
The Death Receptor Fas (CD95 /APO-1) Mediates the Deletion of T Lymphocytes Undergoing Homeostatic Proliferation


Sunday, March 06 | 2:00PM - 4:00PM
Workshop 3: Immune Homeostasis
This session is from Immune Tolerance
Room: Grays Peak

Speaker 6 of 9
Jianying Yang, University of Minnesota, USA
IL-2 Receptor Signaling and Regulatory T Cell Development


Sunday, March 06 | 2:00PM - 4:00PM
Workshop 3: Immune Homeostasis
This session is from Immune Tolerance
Room: Grays Peak

Speaker 7 of 9
Ruka Setoguchi, Kyoto University, Japan
Homeostatic Maintenance of CD25+CD4+ Regulatory T Cells via IL-2 secreted by other T Cells


Sunday, March 06 | 2:00PM - 4:00PM
Workshop 3: Immune Homeostasis
This session is from Immune Tolerance
Room: Grays Peak

Speaker 8 of 9
Adrian Lobito, Genentech, USA
TNF-Receptor 1 Mutations in TRAPS Alter Receptor Trafficking


Sunday, March 06 | 2:00PM - 4:00PM
Workshop 3: Immune Homeostasis
This session is from Immune Tolerance
Room: Grays Peak

Speaker 9 of 9
Hisashi Harada, Virginia Commonwealth University, USA
Survival Factor-Induced ERK Phosphorylates BIM, Inhibiting its Association with BAX and Pro-Apoptotic Activity


Sunday, March 06 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Sunday, March 06 | 5:00PM - 7:00PM
The Mitochondrial Response to Stress
Room: Longs Peak

Speaker 1 of 5
* Thomas Deckwerth, Indepenedent Consultant, USA

Sunday, March 06 | 5:00PM - 7:00PM
The Mitochondrial Response to Stress
Room: Longs Peak

Speaker 2 of 5
Sally A. Kornbluth, Duke University Medical Center, USA
Pre-Mitochondrial Events in Apoptosis


Sunday, March 06 | 5:00PM - 7:00PM
The Mitochondrial Response to Stress
Room: Longs Peak

Speaker 3 of 5
J. Marie Hardwick, Johns Hopkins University Schools of Public Health and Medicine, USA
Regulation of Mitochondrial Morphology and Function

Sunday, March 06 | 5:00PM - 7:00PM
The Mitochondrial Response to Stress
Room: Longs Peak

Speaker 4 of 5
Donald D. Newmeyer, La Jolla Institute for Allergy and Immunology, USA
Mitochondrial Outer Membrane Permeabilization and its Regulation by Bcl-2-Family Proteins

Sunday, March 06 | 5:00PM - 7:00PM
The Mitochondrial Response to Stress
Room: Longs Peak

Speaker 5 of 5
Jerry E. Chipuk, St. Jude Children's Research Hospital, USA
Short Talk: PUMA Couples the Nuclear and Cytoplasmic
Pro-Apoptotic Functions of p53


Sunday, March 06 | 5:00PM - 7:00PM
Maintaining Homeostasis
This session is from Immune Tolerance
Room: Grays Peak

Speaker 1 of 4
* Richard A. Flavell, HHMI/Yale University School of Medicine, USA
T Helper Cell Differentiation


Sunday, March 06 | 5:00PM - 7:00PM
Maintaining Homeostasis
This session is from Immune Tolerance
Room: Grays Peak

Speaker 2 of 4
Brigitta Stockinger, Francis Crick Institute, UK
T Cell Homeostasis and Regulation of Immune Responses


Sunday, March 06 | 5:00PM - 7:00PM
Maintaining Homeostasis
This session is from Immune Tolerance
Room: Grays Peak

Speaker 3 of 4
Warren S. Alexander, Walter and Eliza Hall Institute of Medical Research, Australia
SOCS and Immune Regulation


Sunday, March 06 | 5:00PM - 7:00PM
Maintaining Homeostasis
This session is from Immune Tolerance
Room: Grays Peak

Speaker 4 of 4
Robert Rottapel, Princess Margaret Hospital, Toronto Medical Discovery Tower, Canada
Short Talk: Adapter 3BP2 Regulates B Cell Homeostasis


Sunday, March 06 | 7:00PM - 8:00PM
Social Hour
Room: Shavano/Torreys


Sunday, March 06 | 7:30PM - 10:00PM
Poster Session 3
Room: Shavano/Torreys


Monday, March 07 | 7:00AM - 8:00AM
Breakfast
Room: Shavano/Torreys


Monday, March 07 | 8:00AM - 11:00AM
Cellular Responses to Stress (Joint)
Room: Grays/Longs Peak

Speaker 1 of 5
* Donald W. Nicholson, Nimbus Discovery, Inc., USA

Monday, March 07 | 8:00AM - 11:00AM
Cellular Responses to Stress (Joint)
Room: Grays/Longs Peak

Speaker 2 of 5
Douglas R. Green, St. Jude Children's Research Hospital, USA
Trapping Apoptotic Pathways as they are Engaged

Monday, March 07 | 8:00AM - 11:00AM
Cellular Responses to Stress (Joint)
Room: Grays/Longs Peak

Speaker 3 of 5
Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia
Role of Pro-Apoptic Proteins in Programmed Cell Death in the Immune System, in Tumorigenesis and in Cancer Therapy

Monday, March 07 | 8:00AM - 11:00AM
Cellular Responses to Stress (Joint)
Room: Grays/Longs Peak

Speaker 4 of 5
John M. Abrams, University of Texas Southwestern Medical Center, USA
Programmed Cell Death in the Fly Embryo

Monday, March 07 | 8:00AM - 11:00AM
Cellular Responses to Stress (Joint)
Room: Grays/Longs Peak

Speaker 5 of 5
Michael O. Hengartner, University of Zürich, Switzerland
Damage-Induced Apoptosis in C. elegans


Monday, March 07 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Monday, March 07 | 11:00AM - 1:00PM
Poster Setup
Room: Shavano/Torreys


Monday, March 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Shavano/Torreys


Monday, March 07 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Monday, March 07 | 5:00PM - 7:00PM
Cellular Responses to Telomere Malfunction
Room: Longs Peak

Speaker 1 of 5
* Moshe Oren, Weizmann Institute of Science, Israel

Monday, March 07 | 5:00PM - 7:00PM
Cellular Responses to Telomere Malfunction
Room: Longs Peak

Speaker 2 of 5
Steven E. Artandi, Stanford University, USA
Activation of Hair Follice Stem Cells by TERT, the Protein Subunit of Telomerase

Monday, March 07 | 5:00PM - 7:00PM
Cellular Responses to Telomere Malfunction
Room: Longs Peak

Speaker 3 of 5
Jan Karlseder, The Salk Institute for Biological Studies, USA
Defective Telomere Lagging Strand Synthesis in Cells Lacking WRN Helicase Activity

Monday, March 07 | 5:00PM - 7:00PM
Cellular Responses to Telomere Malfunction
Room: Longs Peak

Speaker 4 of 5
Jerry W. Shay, University of Texas Southwestern Medical Center, USA
Cellular and Molecular Basis of Senescence

Monday, March 07 | 5:00PM - 7:00PM
Cellular Responses to Telomere Malfunction
Room: Longs Peak

Speaker 5 of 5
Dave F. Jarrard, University of Wisconsin-Madison, USA
Short Talk: A Loss of Insulin-Like Growth Factor-2 (IGF2) Imprinting is Modulated by CTCF Downregulation at Senescence in Human Epithelial Cells

Monday, March 07 | 5:00PM - 7:00PM
Mature Lymphocyte Survival
This session is from Immune Tolerance
Room: Grays Peak

Speaker 1 of 4
* Leo Lefrançois, University of Connecticut Health Center, USA
Memory CD8 T cell generation and homeostasis


Monday, March 07 | 5:00PM - 7:00PM
Mature Lymphocyte Survival
This session is from Immune Tolerance
Room: Grays Peak

Speaker 2 of 4
Michael J. Bevan, HHMI/University of Washington, USA
Maintaining Memory


Monday, March 07 | 5:00PM - 7:00PM
Mature Lymphocyte Survival
This session is from Immune Tolerance
Room: Grays Peak

Speaker 3 of 4
Edith Margarethe Janssen, La Jolla Institute for Allergy and Immunology, USA
Short Talk: Trail and Memory


Monday, March 07 | 5:00PM - 7:00PM
Mature Lymphocyte Survival
This session is from Immune Tolerance
Room: Grays Peak

Speaker 4 of 4
Philip G. Ashton-Rickardt, University of Chicago, USA
Short Talk: Serine Protease Inhibitor 2A is a Protective Factor for Memory T Cell Development


Monday, March 07 | 7:00PM - 8:00PM
Social Hour
Room: Shavano/Torreys


Monday, March 07 | 7:30PM - 10:00PM
Poster Session 4
Room: Shavano/Torreys


Tuesday, March 08 | 7:00AM - 8:30AM
Breakfast
Room: Shavano/Torreys


Tuesday, March 08 | 8:00AM - 10:20AM
Disruption of Senescence and Cell Death during Carcinogenesi
s

Room: Longs Peak

Speaker 1 of 4
* Jean Y.J. Wang, University of California, San Diego, USA

Tuesday, March 08 | 8:00AM - 10:20AM
Disruption of Senescence and Cell Death during Carcinogenesi
s

Room: Longs Peak

Speaker 2 of 4
Guido Kroemer, Cordeliers Research Center, France
Cell Death and Genomic Instability

Tuesday, March 08 | 8:00AM - 10:20AM
Disruption of Senescence and Cell Death during Carcinogenesi
s

Room: Longs Peak

Speaker 3 of 4
Thea D. Tlsty, University of California, San Francisco, USA
Stomal Signals Collaborate with Epigenetic and Genetic Changes in Human Epithelial Cells and Create Cancer

Tuesday, March 08 | 8:00AM - 10:20AM
Disruption of Senescence and Cell Death during Carcinogenesi
s

Room: Longs Peak

Speaker 4 of 4
Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Apoptosis and Cellular Senescence

Tuesday, March 08 | 8:00AM - 11:00AM
Homeostasis and Disease
This session is from Immune Tolerance
Room: Grays Peak

Speaker 1 of 4
* Michael J. Lenardo, NIAID, National Institutes of Health, USA
Distinct Programs of Cell Death Govern the Fate of Mamalian Cells


Tuesday, March 08 | 8:00AM - 11:00AM
Homeostasis and Disease
This session is from Immune Tolerance
Room: Grays Peak

Speaker 2 of 4
Gavin R. Screaton, Imperial College London, UK
Homeostasis and Viral Infections


Tuesday, March 08 | 8:00AM - 11:00AM
Homeostasis and Disease
This session is from Immune Tolerance
Room: Grays Peak

Speaker 3 of 4
Nora E. Sarvetnick, University of Nebraska Medical Center, USA
Homeostasis and Autoimmunity


Tuesday, March 08 | 8:00AM - 11:00AM
Homeostasis and Disease
This session is from Immune Tolerance
Room: Grays Peak

Speaker 4 of 4
Daniel C. Douek, NIAID, National Institutes of Health, USA
CD4+ T-cell Depletion During all Stages of HIV Disease Occurs Predominantly in the Gastrointestinal Tract


Tuesday, March 08 | 9:20AM - 9:40AM
Coffee Break
Room: Longs Peak Foyer


Tuesday, March 08 | 10:20AM - 11:15AM
Deciding Cell Fates 1

Speaker 1 of 3
Pier Giuseppe Pelicci, European Institute of Oncology, Italy
Electron Transfer between Cytochrome c and p66Shc Generates
Reactive Oxygen Species that Trigger Mitochondrial Apoptosis


Tuesday, March 08 | 10:20AM - 11:15AM
Deciding Cell Fates 1

Speaker 2 of 3
Marisol S. Soengas, Spanish National Cancer Research Centre, Spain
Short Talk: Selective Killing of Melanoma Cells by Exploiting Differential Effects of Proteasome Inhibition on Noxa and Anti-Apoptotic Bcl-2 Proteins

Tuesday, March 08 | 10:20AM - 11:15AM
Deciding Cell Fates 1

Speaker 3 of 3
Eyal Gottlieb, Technion - Israel Institute of Technology, Israel
Short Talk: Aerobic Glycolysis in Tumours: Novel Mitochondrion-to-Cytosol Signaling Pathway that Shape Cell’s Fate

Tuesday, March 08 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Longs Peak Foyer


Tuesday, March 08 | 5:00PM - 7:00PM
Deciding Cell Fates 2
Room: Longs Peak

Speaker 1 of 5
* Jacqueline A. Lees, Massachusetts Institute of Technology, USA

Tuesday, March 08 | 5:00PM - 7:00PM
Deciding Cell Fates 2
Room: Longs Peak

Speaker 2 of 5
Andrei V. Gudkov, Roswell Park Cancer Institute, USA
Swings of Life and Death: Mutal Regulation of p53 and NF-kappaB

Tuesday, March 08 | 5:00PM - 7:00PM
Deciding Cell Fates 2
Room: Longs Peak

Speaker 3 of 5
Carol L. Prives, Columbia University, USA
Apoptotic Signalling Pathways to the p53 Family

Tuesday, March 08 | 5:00PM - 7:00PM
Deciding Cell Fates 2
Room: Longs Peak

Speaker 4 of 5
Jean Y.J. Wang, University of California, San Diego, USA
Coordinated Regulation of Life and Death by RB

Tuesday, March 08 | 5:00PM - 7:00PM
Deciding Cell Fates 2
Room: Longs Peak

Speaker 5 of 5
Thomas Rudel, University of Würzburg, Germany
Short Talk: A New Factor for an Old Pathway: Ras-Raf-MAPK Signaling Needs Prohibitin

Tuesday, March 08 | 5:00PM - 7:00PM
Therapeutic Applications for Regulators of Apoptosis
This session is from Immune Tolerance
Room: Grays Peak

Speaker 1 of 3
* Donald W. Nicholson, Nimbus Discovery, Inc., USA
Role of Caspase Inhibitors in Human Diseases


Tuesday, March 08 | 5:00PM - 7:00PM
Therapeutic Applications for Regulators of Apoptosis
This session is from Immune Tolerance
Room: Grays Peak

Speaker 2 of 3
Henning Walczak, University College London, Cancer Institute, UK
Therapeutic Options in the TRAIL And CD95 (Fas/APO-1) Death Receptor-Ligand Systems


Tuesday, March 08 | 5:00PM - 7:00PM
Therapeutic Applications for Regulators of Apoptosis
This session is from Immune Tolerance
Room: Grays Peak

Speaker 3 of 3
Kenneth Smith, University of Cambridge, UK
Plan B: Rituximab in Human Autoimmune Disease


Tuesday, March 08 | 7:00PM - 8:00PM
Social Hour
Room: Shavano/Torreys


Tuesday, March 08 | 8:00PM - 11:00PM
Entertainment
Room: Shavano/Torreys


Tuesday, March 08 | 8:00PM - 11:00PM
Cash Bar
Room: Shavano/Torreys


Wednesday, March 09 | 10:26AM - 10:26AM
Departure


*Session Chair.