Web Desc
Cell Polarity and Asymmetric Cell Divisions
joint with Cytoskeletal Systems Interactions in Cellular Morphogenesis
Organizer(s): Norbert Perrimon, Francois Schweisguth and Ben Margolis
Date: March 04 - 08, 2005
Location: Coeur d'Alene Resort, Coeur d'Alene, ID, USA
Supported by The Director's Fund
Summary of Meeting:
The generation of membrane domains with distinct protein constituents is a hallmark of cell polarization. In epithelia, segregation of membrane proteins into apical and basolateral compartments is critical for cell morphology, tissue physiology, and cell signaling. In the past few years, significant discoveries have been made that gave numerous insights on the mechanisms that restrict these determinants to the cell surface. Our understanding of these mechanisms has deep implications in our understanding of cell signaling and cancer for example, as mutations in some of the components involved in organizing cell polarity are associated with tumorous phenotypes. Further, recent studies on the mechanisms underlying asymmetric cell divisions, the process by which one cell gives rise to two daughters of different sizes, have implicated some of the proteins initially thought to be devoted to cell polarity in this process. Finally, reorganization of cell polarity determinants appears to be a critical step in the process of cell delamination and migration from an epithelium. Considering the exciting new findings emerging from studies on cell polarity, cell asymmetry, signal transduction and cell migration, we propose to organize a meeting that will bring together leaders in these fields. The goal of the meeting is to bring together the leading experts that study the mechanism of cell polarization and cell asymmetry to discuss emerging concepts.
Discounted Abstract Deadline: November 4 2004
Discounted Registration Deadline: January 4 2005
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Mental Health (NIMH)
Grant No. 1R13-MH073229-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, March 04 | 3:00PM - 7:30PM
Registration
Room: Conference Center Lobby


Friday, March 04 | 6:30PM - 7:30PM
Refreshments
Room: Bay 4


Friday, March 04 | 7:30PM - 9:30PM
Keith R. Porter Keynote Session (Joint)
Room: Bay 2-3

Speaker 1 of 2
Yuh-Nung Jan, University of California, San Francisco, USA
Extreme Cell Polarity: Morphogenesis of Dendrites versus Axons.


Friday, March 04 | 7:30PM - 9:30PM
Keith R. Porter Keynote Session (Joint)
Room: Bay 2-3

Speaker 2 of 2
J. Victor Small, Austrian Academy of Sciences, Austria
Tailoring the Actin Cytoskelaton for Cell Movement

Saturday, March 05 | 7:00AM - 8:00AM
Breakfast
Room: Bay 4


Saturday, March 05 | 8:00AM - 11:00AM
Cytoskeletal Cross Talk in Polarized Cell Motility (Joint)
Room: Bay 2-3

Speaker 1 of 4
Norbert Perrimon, Harvard Medical School, USA
Signaling Pathways, Cell Polarity and Cytoskeletal Organization during Morphogenesis of Epithelia

Saturday, March 05 | 8:00AM - 11:00AM
Cytoskeletal Cross Talk in Polarized Cell Motility (Joint)
Room: Bay 2-3

Speaker 2 of 4
* Clare M. Waterman-Storer, National Heart, Lung and Blood Institute National Institutes of Health, USA
Spatial Regulation of Microtuble Dynamics by Rac1 in Migrating Epithelial Cells

Saturday, March 05 | 8:00AM - 11:00AM
Cytoskeletal Cross Talk in Polarized Cell Motility (Joint)
Room: Bay 2-3

Speaker 3 of 4
Gregg G. Gundersen, Columbia University, USA
Rho GTPase Regulation of Microtubule Stabilization and Centrosome Position during Cell Migration

Saturday, March 05 | 8:00AM - 11:00AM
Cytoskeletal Cross Talk in Polarized Cell Motility (Joint)
Room: Bay 2-3

Speaker 4 of 4
Ilan Davis, University of Edinburgh, UK
Short Talk: Dynein Dependent mRNA Transport and Anchoring

Saturday, March 05 | 9:20AM - 9:40AM
Coffee Break
Room: Conference Center Lobby


Saturday, March 05 | 11:00AM - 1:00PM
Poster Setup
Room: Bay 5-6


Saturday, March 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay 5-6


Saturday, March 05 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Bay 5-6


Saturday, March 05 | 5:00PM - 7:00PM
Epithelial Polarity
Room: Bay 2

Speaker 1 of 5
* Ben Margolis, University of Michigan, USA
Apical Polarity Complexes in Mammalian Cells

Saturday, March 05 | 5:00PM - 7:00PM
Epithelial Polarity
Room: Bay 2

Speaker 2 of 5
Tony Pawson, Samuel Lunenfeld Research Institute, Canada
Protein Complexes and Interaction Networks in Polarity

Saturday, March 05 | 5:00PM - 7:00PM
Epithelial Polarity
Room: Bay 2

Speaker 3 of 5
Elisabeth Knust, Max Planck Institute of Molecular Cell Biology and Genetics, MPICBG, Germany
Drosophila Crumbs – From Epithelial Cell Polarity to Retinal Degeneration

Saturday, March 05 | 5:00PM - 7:00PM
Epithelial Polarity
Room: Bay 2

Speaker 4 of 5
Ian G. Macara, University of Virginia School of Medicine, USA
Short Talk: Par Proteins and Polarity in Epithelial Nuerons

Saturday, March 05 | 5:00PM - 7:00PM
Epithelial Polarity
Room: Bay 2

Speaker 5 of 5
Tony J.C. Harris, University of North Carolina at Chapel Hill, USA
Short Talk: Establishing the Apical Domain in the Early Drosophila Epithelium

Saturday, March 05 | 5:00PM - 7:15PM
Molecular Mediators of Cytoskeleton Crosslinking
This session is from Cytoskeletal Systems
Room: Bay 3

Speaker 1 of 5
* Tony Koleske, Yale University, USA
Regulation fo Cell and Neuronal Morphogenesis by Abl Kinases


Saturday, March 05 | 5:00PM - 7:15PM
Molecular Mediators of Cytoskeleton Crosslinking
This session is from Cytoskeletal Systems
Room: Bay 3

Speaker 2 of 5
Lee A. Ligon, University of Pennsylvania, USA
Short Talk: Microtubule Plus-End Proteins and Microtubule-Cortex Interactions


Saturday, March 05 | 5:00PM - 7:15PM
Molecular Mediators of Cytoskeleton Crosslinking
This session is from Cytoskeletal Systems
Room: Bay 3

Speaker 3 of 5
John A. Hammer, NHLBI, National Institutes of Health, USA
MyosinV, Melanophilin and EB1at Microtubule plus Ends


Saturday, March 05 | 5:00PM - 7:15PM
Molecular Mediators of Cytoskeleton Crosslinking
This session is from Cytoskeletal Systems
Room: Bay 3

Speaker 4 of 5
Miki Tsukada, Max-Planck-Institute for Experimental Endocrinology, Germany
Short Talk: Doublecortin Association with Actin Filaments is regulated by Neurabin II


Saturday, March 05 | 5:00PM - 7:15PM
Molecular Mediators of Cytoskeleton Crosslinking
This session is from Cytoskeletal Systems
Room: Bay 3

Speaker 5 of 5
William S. Trimble, Hospital for Sick Children, Canada
Septin Activate Rho Kinase to Mediate Myosis Light Chain Phosphorylation


Saturday, March 05 | 7:00PM - 8:00PM
Social Hour
Room: Bay 5-6


Saturday, March 05 | 7:30PM - 10:00PM
Poster Session 1
Room: Bay 5-6


Sunday, March 06 | 7:00AM - 8:00AM
Breakfast
Room: Bay 4


Sunday, March 06 | 8:00AM - 11:00AM
Microtubule/Actin Interactions during Cell Polarization (Joi
nt)

Room: Bay 2-3

Speaker 1 of 5
Inke S. Näthke, University of Dundee, UK
The Adenomatous Polyposis coli Protein in Directed Cell Migration

Sunday, March 06 | 8:00AM - 11:00AM
Microtubule/Actin Interactions during Cell Polarization (Joi
nt)

Room: Bay 2-3

Speaker 2 of 5
Keith E. Mostov, University of California, San Francisco, USA
Polarized Membrane Traffic and Epithelial Morphogenesis

Sunday, March 06 | 8:00AM - 11:00AM
Microtubule/Actin Interactions during Cell Polarization (Joi
nt)

Room: Bay 2-3

Speaker 3 of 5
* Geraldine Seydoux, Johns Hopkins School of Medicine, USA
Par-2 and Stabilzation of Cortical Polatity in the C. elegans Zygote

Sunday, March 06 | 8:00AM - 11:00AM
Microtubule/Actin Interactions during Cell Polarization (Joi
nt)

Room: Bay 2-3

Speaker 4 of 5
Kerry S. Bloom, University of North Carolina at Chapel Hill, USA
The Role of Kar3p, a Minus-End Directed Kinesin, in Mitosis, Spindle Orientation and Karyogamy

Sunday, March 06 | 8:00AM - 11:00AM
Microtubule/Actin Interactions during Cell Polarization (Joi
nt)

Room: Bay 2-3

Speaker 5 of 5
Monica Gotta, Institute of Biochemistry, ETH, Switzerland
Short Talk: New Genes Required for PAR-Dependent Polarity

Sunday, March 06 | 9:20AM - 9:40AM
Coffee Break
Room: Conference Center Lobby


Sunday, March 06 | 11:00AM - 1:00PM
Poster Setup
Room: Bay 5-6


Sunday, March 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay 5-6


Sunday, March 06 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Bay 5-6


Sunday, March 06 | 5:00PM - 7:15PM
Polarity Establishment during Development
Room: Bay 2

Speaker 1 of 4
* Jeffrey D. Axelrod, Stanford University, USA
Understanding the Logic of Planar Cell Polarity Signaling

Sunday, March 06 | 5:00PM - 7:15PM
Polarity Establishment during Development
Room: Bay 2

Speaker 2 of 4
Daniel St. St Johnston, University of Cambridge, UK
Cell Polarity during Drosophila Oogenesis

Sunday, March 06 | 5:00PM - 7:15PM
Polarity Establishment during Development
Room: Bay 2

Speaker 3 of 4
Jennifer A. Zallen, Sloan-Kettering Institute, USA
Molecular Control of Polarized Cell Movement

Sunday, March 06 | 5:00PM - 7:15PM
Polarity Establishment during Development
Room: Bay 2

Speaker 4 of 4
Thomas Lecuit, Universite of Marseille, France
Junction Assembly and Remodeling Underlying Epithelial Morphogenesis

Sunday, March 06 | 5:00PM - 7:15PM
Interactions between Cytoskeletal Systems in Neuronal Functi
on
This session is from Cytoskeletal Systems

Room: Bay 3

Speaker 1 of 5
Shelley Halpain, University of California, San Diego, USA
MAP2 as a Mediator of Microtubule/Actin Interactions in Neurons


Sunday, March 06 | 5:00PM - 7:15PM
Interactions between Cytoskeletal Systems in Neuronal Functi
on
This session is from Cytoskeletal Systems

Room: Bay 3

Speaker 2 of 5
Fengquan Zhou, Johns Hopkins University, USA
Short Talk: Par3/6-PKCzeta Pathway Regulates GSK-3beta Activity and the Function of APC to Mediate Axon Growth


Sunday, March 06 | 5:00PM - 7:15PM
Interactions between Cytoskeletal Systems in Neuronal Functi
on
This session is from Cytoskeletal Systems

Room: Bay 3

Speaker 3 of 5
* Paul Forscher, Yale University, USA
Microtubule-Actin Interactions and their Role in Signaling in Neuronal Growth Cones


Sunday, March 06 | 5:00PM - 7:15PM
Interactions between Cytoskeletal Systems in Neuronal Functi
on
This session is from Cytoskeletal Systems

Room: Bay 3

Speaker 4 of 5
Angela I.M. Barth, Stanford University, USA
Short Talk: APC and beta-Catenin in Neurite Outgrowth and Polarization


Sunday, March 06 | 5:00PM - 7:15PM
Interactions between Cytoskeletal Systems in Neuronal Functi
on
This session is from Cytoskeletal Systems

Room: Bay 3

Speaker 5 of 5
Anthony Brown, Ohio State University, USA
Axonal Transport of Neurofilaments


Sunday, March 06 | 7:15PM - 8:15PM
Social Hour
Room: Bay 5-6


Sunday, March 06 | 7:30PM - 10:00PM
Poster Session 2
Room: Bay 5-6


Monday, March 07 | 7:00AM - 8:00AM
Breakfast
Room: Bay 4


Monday, March 07 | 8:00AM - 11:00AM
Asymmetric Cell Division
Room: Bay 2

Speaker 1 of 3
* François Schweisguth, Ecole Normale Superieure, France
Function and Regulation of the Cell-Fate Determinant Neuralized in Drosophila

Monday, March 07 | 8:00AM - 11:00AM
Asymmetric Cell Division
Room: Bay 2

Speaker 2 of 3
Andrea H. Brand, University of Cambridge, UK
Asymetric Cell Division and Cell Regulation

Monday, March 07 | 8:00AM - 11:00AM
Asymmetric Cell Division
Room: Bay 2

Speaker 3 of 3
Yohanns Bellaïche, Institut Curie, France
Analysing the Function of the Exocyst During Sensory Organ Precursor Cell Asymmetric Division

Monday, March 07 | 8:00AM - 11:00AM
Cytoskeletal Systems Crosstalk during Transient Cellular Asy
mmetries
This session is from Cytoskeletal Systems

Room: Bay 3

Speaker 1 of 5
* William M. Bement, University of Wisconsin-Madison, USA
Conserved RhoA and Cdc42 Signaling Zones in Single Cell Wound Healing and Cytokinetic Apparatus Specification


Monday, March 07 | 8:00AM - 11:00AM
Cytoskeletal Systems Crosstalk during Transient Cellular Asy
mmetries
This session is from Cytoskeletal Systems

Room: Bay 3

Speaker 2 of 5
Victoria Foe, University of Washington, USA
Three Cytomechanical Modules Collaborate to Postition and Time Contractile Furrow Formation: Lessons from Flies, Worms, and Urchins


Monday, March 07 | 8:00AM - 11:00AM
Cytoskeletal Systems Crosstalk during Transient Cellular Asy
mmetries
This session is from Cytoskeletal Systems

Room: Bay 3

Speaker 3 of 5
Mark Peifer, University of North Carolina at Chapel Hill, USA
How is Epithelial Polarity Established in Development


Monday, March 07 | 8:00AM - 11:00AM
Cytoskeletal Systems Crosstalk during Transient Cellular Asy
mmetries
This session is from Cytoskeletal Systems

Room: Bay 3

Speaker 4 of 5
Dahong Zhang, Oregon State University, USA
Microtubule-Mediated Redistribution of Actin Filaments during Contractile Ring Assembly


Monday, March 07 | 8:00AM - 11:00AM
Cytoskeletal Systems Crosstalk during Transient Cellular Asy
mmetries
This session is from Cytoskeletal Systems

Room: Bay 3

Speaker 5 of 5
Paymaan Jafar-Nejad, Baylor College of Medicine, USA
Short Talk: Sec15, a COmponent of the Ecocyst, Promotes Notch Signaling during the Asymmetric Division of Drosophila Sensory Oragan Precursor


Monday, March 07 | 9:20AM - 9:40AM
Coffee Break
Room: Conference Center Lobby


Monday, March 07 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Bay 5-6


Monday, March 07 | 5:00PM - 7:15PM
Cell Signaling and Polarity
Room: Bay 2

Speaker 1 of 6
* Alfonso Martinez Arias, University of Cambridge, UK
Epithelial Cell Movements During Drosophila Dorsal Closure

Monday, March 07 | 5:00PM - 7:15PM
Cell Signaling and Polarity
Room: Bay 2

Speaker 2 of 6
Tadashi Uemura, Kyoto University, Japan
Short Talk: Planar Cell Polarity: Directional
Transport of Frizzled and Polarized Organization of Microtubules


Monday, March 07 | 5:00PM - 7:15PM
Cell Signaling and Polarity
Room: Bay 2

Speaker 3 of 6
David Bilder, University of California, Berkeley, USA
Tumor Suppressor Genes and Cell Polarity

Monday, March 07 | 5:00PM - 7:15PM
Cell Signaling and Polarity
Room: Bay 2

Speaker 4 of 6
Ronen Zaidel-Bar, Weizmann Institute of Science, Israel
Short Talk: Focal Adhesion Signaling Mediates Flow-Induced Cell Polarity

Monday, March 07 | 5:00PM - 7:15PM
Cell Signaling and Polarity
Room: Bay 2

Speaker 5 of 6
Hernán López-Schier, Centre de Regulació Genòmica, Spain
Short Talk: Development and Maintenance of Planar Cell Polarity in the Lateral-line Organ of the Zebrafish

Monday, March 07 | 5:00PM - 7:15PM
Cell Signaling and Polarity
Room: Bay 2

Speaker 6 of 6
Piyi Papadaki, European Molecular Biology Laboratory, Germany
Short Talk: A Chemical Genetic Screen to Identify New Par-1 Targets

Monday, March 07 | 5:00PM - 7:15PM
Regulation of Cytoskeletal Interactions
This session is from Cytoskeletal Systems
Room: Bay 3

Speaker 1 of 5
Janis K. Burkhardt, University of Pennsylvania School of Medicine, USA
Regulation of Actin Dynamics at the Immunological Synapse


Monday, March 07 | 5:00PM - 7:15PM
Regulation of Cytoskeletal Interactions
This session is from Cytoskeletal Systems
Room: Bay 3

Speaker 2 of 5
Sophie G. Martin, Columbia University, USA
Short Talk: Tea4p Links Microtubule Plus Ends with the Actin Nuceator for For3p


Monday, March 07 | 5:00PM - 7:15PM
Regulation of Cytoskeletal Interactions
This session is from Cytoskeletal Systems
Room: Bay 3

Speaker 3 of 5
Kozo Kaibuchi, Nagoya University Graduate School of Medicine, Japan
Neuronal Polarity and Axon Specification


Monday, March 07 | 5:00PM - 7:15PM
Regulation of Cytoskeletal Interactions
This session is from Cytoskeletal Systems
Room: Bay 3

Speaker 4 of 5
Shigenobu Yonemura, RIKEN Center for Developmental Biology, Japan
Short Talk: Microtubule-dependent regulatory mechanism of RhoA localization at the cleavage plane determination


Monday, March 07 | 5:00PM - 7:15PM
Regulation of Cytoskeletal Interactions
This session is from Cytoskeletal Systems
Room: Bay 3

Speaker 5 of 5
* Gary M. Bokoch, The Scripps Research Institute, USA
GEF-H1, a Microtubule-Regulated Rho Exchange Factor, Modulates Rho Function Required for Cytokinesis


Monday, March 07 | 7:00PM - 8:00PM
Social Hour
Room: Bay 5-6


Monday, March 07 | 8:00PM - 11:00PM
Entertainment
Room: Bay 5-6


Tuesday, March 08 | 10:26AM - 10:26AM
Departure


*Session Chair.