Web Desc
Cytoskeletal Systems Interactions in Cellular Morphogenesis
joint with Cell Polarity and Asymmetric Cell Divisions
Organizer(s): Clare M. Waterman-Storer and William M. Bement
Date: March 04 - 08, 2005
Location: Coeur d'Alene Resort, Coeur d'Alene, ID, USA
Supported by The Director's Fund
Summary of Meeting:
The eukaryotic cytoskeleton is composed of three distinct protein polymer systems: microtubules, actin filaments, and intermediate filaments. These cytoskeletal systems differ from each other in a variety of fundamental ways, and each is associated with characteristic accessory and regulatory proteins. For these reasons, the three systems have classically been studied in isolation. However, it is becoming increasingly apparent that interactions between microtubules, actin filaments, and intermediate filaments not only occur in vivo, but are essential for a variety of fundamental cellular processes ranging from cell division and cell locomotion, to polarity development during early embryogenesis and neuronal path finding. The recent inroads into understanding the cellular and molecular bases of cytoskeletal systems interactions have resulted from advances in high resolution imaging techniques as well as the application of molecular, genetic and biochemical approaches to identify proteins that directly and indirectly link the three systems. This meeting will draw together investigators who are studying the interactions of cytoskeletal systems in different cellular processes, using different approaches, and employing different model organisms. The goal of the meeting is to elucidate the cellular behaviors in which cytoskeletal interactions play a key role, to determine the fundamental types interactions between cytoskeletal systems, discuss their degree of conservation or specialization in different processes, and identify key molecules mediating these interactions. Accordingly, the presentations are structured such that each day combines a series of talks from investigators using a systems approach, to provide cellular context, with a series of talks from investigators working at a more reductionistic level, to provide insights into the functioning of key molecular players.
Discounted Abstract Deadline: November 4 2004
Discounted Registration Deadline: January 4 2005
We gratefully acknowledge additional support for this conference from:

Keith R. Porter Endowment Fund
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, March 04 | 3:00PM - 7:30PM
Registration
Room: Conference Center Lobby


Friday, March 04 | 6:30PM - 7:30PM
Refreshments
Room: Bay 4


Friday, March 04 | 7:30PM - 9:30PM
Keith R. Porter Keynote Session (Joint)
Room: Bay 2-3

Speaker 2 of 2
J. Victor Small, Austrian Academy of Sciences, Austria
Tailoring the Actin Cytoskelaton for Cell Movement

Friday, March 04 | 7:30PM - 9:30PM
Keith R. Porter Keynote Session (Joint)
Room: Bay 2-3

Speaker 1 of 2
Yuh-Nung Jan, University of California, San Francisco, USA
Extreme Cell Polarity: Morphogenesis of Dendrites versus Axons.


Saturday, March 05 | 7:00AM - 8:00AM
Breakfast
Room: Bay 4


Saturday, March 05 | 8:00AM - 11:00AM
Cytoskeletal Cross Talk in Polarized Cell Motility (Joint)
Room: Bay 2-3

Speaker 4 of 4
Ilan Davis, University of Edinburgh, UK
Short Talk: Dynein Dependent mRNA Transport and Anchoring

Saturday, March 05 | 8:00AM - 11:00AM
Cytoskeletal Cross Talk in Polarized Cell Motility (Joint)
Room: Bay 2-3

Speaker 3 of 4
Gregg G. Gundersen, Columbia University, USA
Rho GTPase Regulation of Microtubule Stabilization and Centrosome Position during Cell Migration

Saturday, March 05 | 8:00AM - 11:00AM
Cytoskeletal Cross Talk in Polarized Cell Motility (Joint)
Room: Bay 2-3

Speaker 2 of 4
* Clare M. Waterman-Storer, National Heart, Lung and Blood Institute National Institutes of Health, USA
Spatial Regulation of Microtuble Dynamics by Rac1 in Migrating Epithelial Cells

Saturday, March 05 | 8:00AM - 11:00AM
Cytoskeletal Cross Talk in Polarized Cell Motility (Joint)
Room: Bay 2-3

Speaker 1 of 4
Norbert Perrimon, Harvard Medical School, USA
Signaling Pathways, Cell Polarity and Cytoskeletal Organization during Morphogenesis of Epithelia

Saturday, March 05 | 9:20AM - 9:40AM
Coffee Break
Room: Conference Center Lobby


Saturday, March 05 | 11:00AM - 1:00PM
Poster Setup
Room: Bay 5-6


Saturday, March 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay 5-6


Saturday, March 05 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Bay 5-6


Saturday, March 05 | 5:00PM - 7:00PM
Epithelial Polarity
This session is from Cell Polarity
Room: Bay 2

Speaker 5 of 5
Tony J.C. Harris, University of North Carolina at Chapel Hill, USA
Short Talk: Establishing the Apical Domain in the Early Drosophila Epithelium


Saturday, March 05 | 5:00PM - 7:00PM
Epithelial Polarity
This session is from Cell Polarity
Room: Bay 2

Speaker 4 of 5
Ian G. Macara, University of Virginia School of Medicine, USA
Short Talk: Par Proteins and Polarity in Epithelial Nuerons


Saturday, March 05 | 5:00PM - 7:00PM
Epithelial Polarity
This session is from Cell Polarity
Room: Bay 2

Speaker 3 of 5
Elisabeth Knust, Max Planck Institute of Molecular Cell Biology and Genetics, MPICBG, Germany
Drosophila Crumbs – From Epithelial Cell Polarity to Retinal Degeneration


Saturday, March 05 | 5:00PM - 7:00PM
Epithelial Polarity
This session is from Cell Polarity
Room: Bay 2

Speaker 2 of 5
Tony Pawson, Samuel Lunenfeld Research Institute, Canada
Protein Complexes and Interaction Networks in Polarity


Saturday, March 05 | 5:00PM - 7:00PM
Epithelial Polarity
This session is from Cell Polarity
Room: Bay 2

Speaker 1 of 5
* Ben Margolis, University of Michigan, USA
Apical Polarity Complexes in Mammalian Cells


Saturday, March 05 | 5:00PM - 7:15PM
Molecular Mediators of Cytoskeleton Crosslinking
Room: Bay 3

Speaker 5 of 5
William S. Trimble, Hospital for Sick Children, Canada
Septin Activate Rho Kinase to Mediate Myosis Light Chain Phosphorylation

Saturday, March 05 | 5:00PM - 7:15PM
Molecular Mediators of Cytoskeleton Crosslinking
Room: Bay 3

Speaker 4 of 5
Miki Tsukada, Max-Planck-Institute for Experimental Endocrinology, Germany
Short Talk: Doublecortin Association with Actin Filaments is regulated by Neurabin II

Saturday, March 05 | 5:00PM - 7:15PM
Molecular Mediators of Cytoskeleton Crosslinking
Room: Bay 3

Speaker 3 of 5
John A. Hammer, NHLBI, National Institutes of Health, USA
MyosinV, Melanophilin and EB1at Microtubule plus Ends

Saturday, March 05 | 5:00PM - 7:15PM
Molecular Mediators of Cytoskeleton Crosslinking
Room: Bay 3

Speaker 2 of 5
Lee A. Ligon, University of Pennsylvania, USA
Short Talk: Microtubule Plus-End Proteins and Microtubule-Cortex Interactions

Saturday, March 05 | 5:00PM - 7:15PM
Molecular Mediators of Cytoskeleton Crosslinking
Room: Bay 3

Speaker 1 of 5
* Tony Koleske, Yale University, USA
Regulation fo Cell and Neuronal Morphogenesis by Abl Kinases

Saturday, March 05 | 7:00PM - 8:00PM
Social Hour
Room: Bay 5-6


Saturday, March 05 | 7:30PM - 10:00PM
Poster Session 1
Room: Bay 5-6


Sunday, March 06 | 7:00AM - 8:00AM
Breakfast
Room: Bay 4


Sunday, March 06 | 8:00AM - 11:00AM
Microtubule/Actin Interactions during Cell Polarization (Joi
nt)

Room: Bay 2-3

Speaker 1 of 5
Inke S. Näthke, University of Dundee, UK
The Adenomatous Polyposis coli Protein in Directed Cell Migration

Sunday, March 06 | 8:00AM - 11:00AM
Microtubule/Actin Interactions during Cell Polarization (Joi
nt)

Room: Bay 2-3

Speaker 2 of 5
Keith E. Mostov, University of California, San Francisco, USA
Polarized Membrane Traffic and Epithelial Morphogenesis

Sunday, March 06 | 8:00AM - 11:00AM
Microtubule/Actin Interactions during Cell Polarization (Joi
nt)

Room: Bay 2-3

Speaker 3 of 5
* Geraldine Seydoux, Johns Hopkins School of Medicine, USA
Par-2 and Stabilzation of Cortical Polatity in the C. elegans Zygote

Sunday, March 06 | 8:00AM - 11:00AM
Microtubule/Actin Interactions during Cell Polarization (Joi
nt)

Room: Bay 2-3

Speaker 4 of 5
Kerry S. Bloom, University of North Carolina at Chapel Hill, USA
The Role of Kar3p, a Minus-End Directed Kinesin, in Mitosis, Spindle Orientation and Karyogamy

Sunday, March 06 | 8:00AM - 11:00AM
Microtubule/Actin Interactions during Cell Polarization (Joi
nt)

Room: Bay 2-3

Speaker 5 of 5
Monica Gotta, Institute of Biochemistry, ETH, Switzerland
Short Talk: New Genes Required for PAR-Dependent Polarity

Sunday, March 06 | 9:20AM - 9:40AM
Coffee Break
Room: Conference Center Lobby


Sunday, March 06 | 11:00AM - 1:00PM
Poster Setup
Room: Bay 5-6


Sunday, March 06 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay 5-6


Sunday, March 06 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Bay 5-6


Sunday, March 06 | 5:00PM - 7:15PM
Interactions between Cytoskeletal Systems in Neuronal Functi
on

Room: Bay 3

Speaker 1 of 5
Shelley Halpain, University of California, San Diego, USA
MAP2 as a Mediator of Microtubule/Actin Interactions in Neurons

Sunday, March 06 | 5:00PM - 7:15PM
Interactions between Cytoskeletal Systems in Neuronal Functi
on

Room: Bay 3

Speaker 2 of 5
Fengquan Zhou, Johns Hopkins University, USA
Short Talk: Par3/6-PKCzeta Pathway Regulates GSK-3beta Activity and the Function of APC to Mediate Axon Growth

Sunday, March 06 | 5:00PM - 7:15PM
Interactions between Cytoskeletal Systems in Neuronal Functi
on

Room: Bay 3

Speaker 3 of 5
* Paul Forscher, Yale University, USA
Microtubule-Actin Interactions and their Role in Signaling in Neuronal Growth Cones

Sunday, March 06 | 5:00PM - 7:15PM
Interactions between Cytoskeletal Systems in Neuronal Functi
on

Room: Bay 3

Speaker 4 of 5
Angela I.M. Barth, Stanford University, USA
Short Talk: APC and beta-Catenin in Neurite Outgrowth and Polarization

Sunday, March 06 | 5:00PM - 7:15PM
Interactions between Cytoskeletal Systems in Neuronal Functi
on

Room: Bay 3

Speaker 5 of 5
Anthony Brown, Ohio State University, USA
Axonal Transport of Neurofilaments

Sunday, March 06 | 5:00PM - 7:15PM
Polarity Establishment during Development
This session is from Cell Polarity
Room: Bay 2

Speaker 1 of 4
* Jeffrey D. Axelrod, Stanford University, USA
Understanding the Logic of Planar Cell Polarity Signaling


Sunday, March 06 | 5:00PM - 7:15PM
Polarity Establishment during Development
This session is from Cell Polarity
Room: Bay 2

Speaker 2 of 4
Daniel St. St Johnston, University of Cambridge, UK
Cell Polarity during Drosophila Oogenesis


Sunday, March 06 | 5:00PM - 7:15PM
Polarity Establishment during Development
This session is from Cell Polarity
Room: Bay 2

Speaker 3 of 4
Jennifer A. Zallen, Sloan-Kettering Institute, USA
Molecular Control of Polarized Cell Movement


Sunday, March 06 | 5:00PM - 7:15PM
Polarity Establishment during Development
This session is from Cell Polarity
Room: Bay 2

Speaker 4 of 4
Thomas Lecuit, Universite of Marseille, France
Junction Assembly and Remodeling Underlying Epithelial Morphogenesis


Sunday, March 06 | 7:15PM - 8:15PM
Social Hour
Room: Bay 5-6


Sunday, March 06 | 7:30PM - 10:00PM
Poster Session 2
Room: Bay 5-6


Monday, March 07 | 7:00AM - 8:00AM
Breakfast
Room: Bay 4


Monday, March 07 | 8:00AM - 11:00AM
Cytoskeletal Systems Crosstalk during Transient Cellular Asy
mmetries

Room: Bay 3

Speaker 1 of 5
* William M. Bement, University of Wisconsin-Madison, USA
Conserved RhoA and Cdc42 Signaling Zones in Single Cell Wound Healing and Cytokinetic Apparatus Specification

Monday, March 07 | 8:00AM - 11:00AM
Cytoskeletal Systems Crosstalk during Transient Cellular Asy
mmetries

Room: Bay 3

Speaker 2 of 5
Victoria Foe, University of Washington, USA
Three Cytomechanical Modules Collaborate to Postition and Time Contractile Furrow Formation: Lessons from Flies, Worms, and Urchins

Monday, March 07 | 8:00AM - 11:00AM
Cytoskeletal Systems Crosstalk during Transient Cellular Asy
mmetries

Room: Bay 3

Speaker 3 of 5
Mark Peifer, University of North Carolina at Chapel Hill, USA
How is Epithelial Polarity Established in Development

Monday, March 07 | 8:00AM - 11:00AM
Cytoskeletal Systems Crosstalk during Transient Cellular Asy
mmetries

Room: Bay 3

Speaker 4 of 5
Dahong Zhang, Oregon State University, USA
Microtubule-Mediated Redistribution of Actin Filaments during Contractile Ring Assembly

Monday, March 07 | 8:00AM - 11:00AM
Cytoskeletal Systems Crosstalk during Transient Cellular Asy
mmetries

Room: Bay 3

Speaker 5 of 5
Paymaan Jafar-Nejad, Baylor College of Medicine, USA
Short Talk: Sec15, a COmponent of the Ecocyst, Promotes Notch Signaling during the Asymmetric Division of Drosophila Sensory Oragan Precursor

Monday, March 07 | 8:00AM - 11:00AM
Asymmetric Cell Division
This session is from Cell Polarity
Room: Bay 2

Speaker 1 of 3
* François Schweisguth, Ecole Normale Superieure, France
Function and Regulation of the Cell-Fate Determinant Neuralized in Drosophila


Monday, March 07 | 8:00AM - 11:00AM
Asymmetric Cell Division
This session is from Cell Polarity
Room: Bay 2

Speaker 2 of 3
Andrea H. Brand, University of Cambridge, UK
Asymetric Cell Division and Cell Regulation


Monday, March 07 | 8:00AM - 11:00AM
Asymmetric Cell Division
This session is from Cell Polarity
Room: Bay 2

Speaker 3 of 3
Yohanns Bellaïche, Institut Curie, France
Analysing the Function of the Exocyst During Sensory Organ Precursor Cell Asymmetric Division


Monday, March 07 | 9:20AM - 9:40AM
Coffee Break
Room: Conference Center Lobby


Monday, March 07 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Bay 5-6


Monday, March 07 | 5:00PM - 7:15PM
Regulation of Cytoskeletal Interactions
Room: Bay 3

Speaker 1 of 5
Janis K. Burkhardt, University of Pennsylvania School of Medicine, USA
Regulation of Actin Dynamics at the Immunological Synapse

Monday, March 07 | 5:00PM - 7:15PM
Regulation of Cytoskeletal Interactions
Room: Bay 3

Speaker 2 of 5
Sophie G. Martin, Columbia University, USA
Short Talk: Tea4p Links Microtubule Plus Ends with the Actin Nuceator for For3p

Monday, March 07 | 5:00PM - 7:15PM
Regulation of Cytoskeletal Interactions
Room: Bay 3

Speaker 3 of 5
Kozo Kaibuchi, Nagoya University Graduate School of Medicine, Japan
Neuronal Polarity and Axon Specification

Monday, March 07 | 5:00PM - 7:15PM
Regulation of Cytoskeletal Interactions
Room: Bay 3

Speaker 4 of 5
Shigenobu Yonemura, RIKEN Center for Developmental Biology, Japan
Short Talk: Microtubule-dependent regulatory mechanism of RhoA localization at the cleavage plane determination

Monday, March 07 | 5:00PM - 7:15PM
Regulation of Cytoskeletal Interactions
Room: Bay 3

Speaker 5 of 5
* Gary M. Bokoch, The Scripps Research Institute, USA
GEF-H1, a Microtubule-Regulated Rho Exchange Factor, Modulates Rho Function Required for Cytokinesis

Monday, March 07 | 5:00PM - 7:15PM
Cell Signaling and Polarity
This session is from Cell Polarity
Room: Bay 2

Speaker 1 of 6
* Alfonso Martinez Arias, University of Cambridge, UK
Epithelial Cell Movements During Drosophila Dorsal Closure


Monday, March 07 | 5:00PM - 7:15PM
Cell Signaling and Polarity
This session is from Cell Polarity
Room: Bay 2

Speaker 2 of 6
Tadashi Uemura, Kyoto University, Japan
Short Talk: Planar Cell Polarity: Directional
Transport of Frizzled and Polarized Organization of Microtubules


Monday, March 07 | 5:00PM - 7:15PM
Cell Signaling and Polarity
This session is from Cell Polarity
Room: Bay 2

Speaker 3 of 6
David Bilder, University of California, Berkeley, USA
Tumor Suppressor Genes and Cell Polarity


Monday, March 07 | 5:00PM - 7:15PM
Cell Signaling and Polarity
This session is from Cell Polarity
Room: Bay 2

Speaker 4 of 6
Ronen Zaidel-Bar, Weizmann Institute of Science, Israel
Short Talk: Focal Adhesion Signaling Mediates Flow-Induced Cell Polarity


Monday, March 07 | 5:00PM - 7:15PM
Cell Signaling and Polarity
This session is from Cell Polarity
Room: Bay 2

Speaker 5 of 6
Hernán López-Schier, Centre de Regulació Genòmica, Spain
Short Talk: Development and Maintenance of Planar Cell Polarity in the Lateral-line Organ of the Zebrafish


Monday, March 07 | 5:00PM - 7:15PM
Cell Signaling and Polarity
This session is from Cell Polarity
Room: Bay 2

Speaker 6 of 6
Piyi Papadaki, European Molecular Biology Laboratory, Germany
Short Talk: A Chemical Genetic Screen to Identify New Par-1 Targets


Monday, March 07 | 7:00PM - 8:00PM
Social Hour
Room: Bay 5-6


Monday, March 07 | 8:00PM - 11:00PM
Entertainment
Room: Bay 5-6


Tuesday, March 08 | 10:26AM - 10:26AM
Departure


*Session Chair.