Web Desc
Molecular Helminthology: An Integrated Approach
joint with Drugs Against Protozoan Parasites: Target Selection, Structural Biology and Medicinal Chemistry
Organizer(s): Philip T. LoVerde
Date: April 09 - 13, 2005
Location: Copper Mountain Resort, Copper Mountain, CO, USA
Part of the Global Health Series, Supported by the Bill & Melinda Gates Foundation and Sponsored by the International Center for Tropical Disease Research
Summary of Meeting:
This is an exciting time for the field of helminth host-parasite co-evolution. Advances in molecular and cellular biology of helminth parasite interactions with their hosts are being and are expected to accelerate as the genomic sequence of Schistosoma mansoni and Brugia malayi will each be at 3X coverage and more than 200,000 ESTs for Schistosoma and over 100,000 ESTs for nematode species will be available by the end of 2003. A renaissance of approach with studies on the transcriptome and proteome and of technology and tools, such as gene transfers, gene knockouts and RNA interference is underway. These tools, the manipulations and hypotheses they will allow, will be the topics for this unique conference. By the year 2005 the fruits of the new information and technological advances will be available. The Conference which combines broad areas of helminth research ranging from basic science such as developmental biology, signal transduction, neurobiology and functional genomics translated to the applied aspects such as targets for vaccine and drug design and drug resistance has as its theme how host and parasite molecules each contribute to host-parasite co-evolution. It is expected that the conference will promote collaboration among researchers with the goal of identifying new targets for the development of drugs, vaccines, and diagnostic tests, by providing the biological and informatic resources and tools for their rapid characterization and analysis, by analyzing the biological basis of host-parasite interactions and by attracting new young talent to the field. Certainly there are fascinating scientific questions waiting to be answered about helminths. Some of those questions have as their central theme the very nature of parasitism.
Discounted Abstract Deadline: December 8 2004
Discounted Registration Deadline: February 9 2005
We gratefully acknowledge additional support for this conference from:
Bill & Melinda Gates FoundationBurroughs Wellcome FundInternational Center for Tropical Disease Research
New England Biolabs, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13-AI063801-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Saturday, April 09 | 3:00PM - 7:30PM
Registration
Room: Kokopelli's


Saturday, April 09 | 6:30PM - 7:30PM
Refreshments
Room: Kokopelli's


Saturday, April 09 | 7:30PM - 8:30PM
Keynote Address
Room: Bighorn B

Speaker 1 of 1
Vincent P. Laudet, Ecole Normale Superieure, France
Evolution of Nuclear Receptors


Sunday, April 10 | 7:00AM - 8:00AM
Breakfast
Room: Ptarmigan


Sunday, April 10 | 8:00AM - 11:15AM
Comparative Biology. Session Sponsored by The Ellison Medic
al Foundation
This session is from Protozoan Parasites

Room: Bighorn C

Speaker 7 of 7
Achim Schnaufer, University of Edinburgh, UK
Short Talk: RNA Editing as a Drug Target in Trypanosomatids


Sunday, April 10 | 8:00AM - 11:15AM
Comparative Biology. Session Sponsored by The Ellison Medic
al Foundation
This session is from Protozoan Parasites

Room: Bighorn C

Speaker 6 of 7
Tomoyoshi Nozaki, Gunma University Graduate School of Medicine, Japan
Short Talk: Sulfur-Containing Amino Acid Degradation as a Drug Target for Amebiasis: Biochemical and Structural analyses of Methionine gamma-Lyase from Entamoeba histolytica


Sunday, April 10 | 8:00AM - 11:15AM
Comparative Biology. Session Sponsored by The Ellison Medic
al Foundation
This session is from Protozoan Parasites

Room: Bighorn C

Speaker 5 of 7
William N. Hunter, University of Dundee, UK
Isoprenoid Biosynthetic Enzymes


Sunday, April 10 | 8:00AM - 11:15AM
Comparative Biology. Session Sponsored by The Ellison Medic
al Foundation
This session is from Protozoan Parasites

Room: Bighorn C

Speaker 4 of 7
Kasturi Haldar, University of Notre Dame, USA
Host-Pathogen Interactions as Targets in Malarial Infection


Sunday, April 10 | 8:00AM - 11:15AM
Comparative Biology. Session Sponsored by The Ellison Medic
al Foundation
This session is from Protozoan Parasites

Room: Bighorn C

Speaker 3 of 7
Daniel E. Goldberg, Washington University, USA
Plasmepsins as Antimalarial Targets


Sunday, April 10 | 8:00AM - 11:15AM
Comparative Biology. Session Sponsored by The Ellison Medic
al Foundation
This session is from Protozoan Parasites

Room: Bighorn C

Speaker 2 of 7
Alan H. Fairlamb, University of Dundee, UK
Enzymes of Trypanothione Metabolism


Sunday, April 10 | 8:00AM - 11:15AM
Comparative Biology. Session Sponsored by The Ellison Medic
al Foundation
This session is from Protozoan Parasites

Room: Bighorn C

Speaker 1 of 7
* Dyann F. Wirth, Harvard School of Public Health, USA


Sunday, April 10 | 8:00AM - 11:15AM
Status of Helminth Genome Projects
Room: Bighorn B

Speaker 6 of 6
Fiona J. Thompson, University of Oxford, UK
Short Talk: An EST Analysis of the Life-Cycle of the Parasitic Nematode Strongyloides ratti

Sunday, April 10 | 8:00AM - 11:15AM
Status of Helminth Genome Projects
Room: Bighorn B

Speaker 5 of 6
Makedonka Mitreva, Washington University School of Medicine, USA
Investigating Hookworm Genomes by Comparative Analysis of Two Ancylostoma Species

Sunday, April 10 | 8:00AM - 11:15AM
Status of Helminth Genome Projects
Room: Bighorn B

Speaker 4 of 6
Barton E. Slatko, New England Biolabs, USA
The Genome of Wolbachia: A Parasite within the Human Filarial Parasite, Brugia malayi

Sunday, April 10 | 8:00AM - 11:15AM
Status of Helminth Genome Projects
Room: Bighorn B

Speaker 3 of 6
Elodie Ghedin, New York University, USA
Whole-Genome Analysis of the Parasitic Nematode Brugia malayi


Sunday, April 10 | 8:00AM - 11:15AM
Status of Helminth Genome Projects
Room: Bighorn B

Speaker 2 of 6
Matthew Berriman, Wellcome Sanger Institute, UK
Short Talk: The Schistosoma mansoni Genome Project at the Sanger Institute and access via SchistoDB

Sunday, April 10 | 8:00AM - 11:15AM
Status of Helminth Genome Projects
Room: Bighorn B

Speaker 1 of 6
* Najib M. El-Sayed, University of Maryland, USA
The Schistosoma mansoni Genome Project

Sunday, April 10 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Sunday, April 10 | 11:15AM - 1:00PM
Poster Setup
Room: Bighorn


Sunday, April 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Bighorn


Sunday, April 10 | 2:30PM - 4:30PM
Workshop: Funding Opportunities
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 1 of 6
* Akhil B. Vaidya, Drexel University College of Medicine, USA


Sunday, April 10 | 2:30PM - 4:30PM
Workshop: Funding Opportunities
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 2 of 6
Robert Ridley, World Health Organization, Switzerland


Sunday, April 10 | 2:30PM - 4:30PM
Workshop: Funding Opportunities
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 3 of 6
Solomon O. Nwaka, World Health Organization, Switzerland
Virtual Drug Discovery: lessons learned from public-private partnerships


Sunday, April 10 | 2:30PM - 4:30PM
Workshop: Funding Opportunities
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 4 of 6
Martin John Rogers, NIAID, National Institutes of Health, USA


Sunday, April 10 | 2:30PM - 4:30PM
Workshop: Funding Opportunities
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 5 of 6
Philip E. Coyne, Uniformed Services University of the Health Sciences, USA


Sunday, April 10 | 2:30PM - 4:30PM
Workshop: Funding Opportunities
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 6 of 6
Simon L. Croft, London School of Hygiene & Tropical Medicine, UK


Sunday, April 10 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Kokopelli's


Sunday, April 10 | 5:00PM - 7:00PM
Transcriptome and Proteome of Helminths
Room: Bighorn B

Speaker 1 of 5
* Karl F. Hoffmann, University of Cambridge, UK
Identifying Drug Targets From Transcriptome Analysis Of Schistosome Conjugal Biology

Sunday, April 10 | 5:00PM - 7:00PM
Transcriptome and Proteome of Helminths
Room: Bighorn B

Speaker 2 of 5
Peter Ashton, University of York, UK
Studies on the Schistosome Proteome

Sunday, April 10 | 5:00PM - 7:00PM
Transcriptome and Proteome of Helminths
Room: Bighorn B

Speaker 3 of 5
Cornelis H. Hokke, Leiden University Medical Center, Netherlands
Schistosome Glycoproteomics: Global Approaches - Detailed Findings

Sunday, April 10 | 5:00PM - 7:00PM
Transcriptome and Proteome of Helminths
Room: Bighorn B

Speaker 4 of 5
Ben-Wen Li, Washington University School of Medicine, USA
Short Talk: Profiling of Gender-Regulated Gene Transcripts in the Filarial Nematode Brugia malayi by cDNA Oligonucleotide Array Analysis

Sunday, April 10 | 5:00PM - 7:00PM
Transcriptome and Proteome of Helminths
Room: Bighorn B

Speaker 5 of 5
Steven A. Williams, Smith College, USA
Short Talk: An Update on the New Bruzui Malayi Microarray and other Resources Available through FR3

Sunday, April 10 | 5:00PM - 7:00PM
Functional Genomics
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 1 of 6
* Stephen M. Beverley, Washington University School of Medicine, USA


Sunday, April 10 | 5:00PM - 7:00PM
Functional Genomics
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 2 of 6
Brendan S. Crabb, Burnet Institute, Australia
The Plasmodium falciparum SERA Proteases are Novel Drug Targets


Sunday, April 10 | 5:00PM - 7:00PM
Functional Genomics
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 3 of 6
Gary E. Ward, University of Vermont, USA
Using Small Molecules to Study Host Cell Invasion by T. gondii


Sunday, April 10 | 5:00PM - 7:00PM
Functional Genomics
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 4 of 6
Elizabeth A. Winzeler, University of California, San Diego, USA
Short Talk: Systematic Determination of the Targets of Drug Resistance and Immunity


Sunday, April 10 | 5:00PM - 7:00PM
Functional Genomics
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 5 of 6
Bo Wu, University of Pennsylvania, USA
Short Talk: Heme Metabolism in Apicomplexan Parasites


Sunday, April 10 | 5:00PM - 7:00PM
Functional Genomics
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 6 of 6
Paul Hunt, University of Edinburgh, UK
Short Talk: Linkage Group Selection – A Rapid Molecular Genetics Strategy for Identifying loci Underlying Drug Resistance


Sunday, April 10 | 7:00PM - 8:00PM
Social Hour
Room: Kokopelli's


Sunday, April 10 | 7:30PM - 10:00PM
Poster Session 1
Room: Bighorn B


Monday, April 11 | 7:00AM - 8:00AM
Breakfast
Room: Ptarmigan


Monday, April 11 | 8:00AM - 11:15AM
Tools to Manipulate Helminth Gene Expression
Room: Bighorn B

Speaker 1 of 6
* Richard E. Davis, University of Colorado School of Medicine, USA
In vivo and in vitro Analysis of Gene Expression in Helminths

Monday, April 11 | 8:00AM - 11:15AM
Tools to Manipulate Helminth Gene Expression
Room: Bighorn B

Speaker 2 of 6
Timothy P. Yoshino, University of Wisconsin-Madison, USA
Gene “muffling” by RNAi in larval schistosomes: an effective functional genomics tool?

Monday, April 11 | 8:00AM - 11:15AM
Tools to Manipulate Helminth Gene Expression
Room: Bighorn B

Speaker 3 of 6
Christoph G. Grevelding, Institute for Parasitology, Germany
Short Talk: Transgenic Schistosomes: Progress and Challenges

Monday, April 11 | 8:00AM - 11:15AM
Tools to Manipulate Helminth Gene Expression
Room: Bighorn B

Speaker 4 of 6
Mark L. Blaxter, University of Edinburgh, UK
Comparative Nematode Genomics: Exploiting Expressed Sequence Tag and Genome Surveys of Nuclear and Symbiont Genomes

Monday, April 11 | 8:00AM - 11:15AM
Tools to Manipulate Helminth Gene Expression
Room: Bighorn B

Speaker 5 of 6
James B. Lok, University of Pennsylvania, USA
Transfection in Strongyloides

Monday, April 11 | 8:00AM - 11:15AM
Tools to Manipulate Helminth Gene Expression
Room: Bighorn B

Speaker 6 of 6
Sara Lustigman, New York Blood Center, USA
Short Talk: Cysteine Proteases of Filarial Nematodes: From Genome to Biology

Monday, April 11 | 8:00AM - 11:15AM
Established Drugs and Targets
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 1 of 7
* James H. McKerrow, University of California, San Diego, USA


Monday, April 11 | 8:00AM - 11:15AM
Established Drugs and Targets
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 2 of 7
Sanjeev Krishna, St. George's Hospital Medical School, UK
Artemisinin Targets


Monday, April 11 | 8:00AM - 11:15AM
Established Drugs and Targets
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 3 of 7
Francisco Gamarro, Consejo Superior de Investigaciones Científicas, Spain
Mechanism of Miltefosine Resistance in Leishmania


Monday, April 11 | 8:00AM - 11:15AM
Established Drugs and Targets
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 4 of 7
Stephen A. Ward, Liverpool School of Tropical Medicine, UK
Quinoline QSAR and Heme Access


Monday, April 11 | 8:00AM - 11:15AM
Established Drugs and Targets
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 5 of 7
Paul D. Roepe, Georgetown University, USA
Analysis of Pfcrt Function: Toward a Molecular Understanding of Chloroquine Resistance


Monday, April 11 | 8:00AM - 11:15AM
Established Drugs and Targets
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 6 of 7
Barry P. Rosen, Florida International University, USA
Short Talk: Pentostam Activation and Uptake in Leishmania major: Role of the Sb(V) Reductase LmAcr2 and the Aquaglyceroporin LmAqp1


Monday, April 11 | 8:00AM - 11:15AM
Established Drugs and Targets
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 7 of 7
Maria Paola Costi, University of Modena and Reggio Emilia, Italy
Short Talk: Inhibition of the Folate Pathway in Parasites: Do Antifolates Still Work?


Monday, April 11 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Monday, April 11 | 11:15AM - 1:00PM
Poster Setup
Room: Bighorn


Monday, April 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Bighorn


Monday, April 11 | 2:30PM - 4:30PM
Workshop: RNAi/Transfections in Helminths

Speaker 1 of 9
* Christoph G. Grevelding, Institute for Parasitology, Germany

Monday, April 11 | 2:30PM - 4:30PM
Workshop: RNAi/Transfections in Helminths

Speaker 2 of 9
* Sara Lustigman, New York Blood Center, USA

Monday, April 11 | 2:30PM - 4:30PM
Workshop: RNAi/Transfections in Helminths

Speaker 3 of 9
Karen L. Bennett, University of Missouri, USA
Cross-Species RNAi: Ascaris Genes Sterilize C. elegans

Monday, April 11 | 2:30PM - 4:30PM
Workshop: RNAi/Transfections in Helminths

Speaker 4 of 9
Jason M. Correnti, Thomas Jefferson University, USA
Longterm Suppression of Cathepsin B Levels by RNAi Retards Schistosome Growth

Monday, April 11 | 2:30PM - 4:30PM
Workshop: RNAi/Transfections in Helminths

Speaker 5 of 9
Julie-Anne Fritz, Australian National University, Australia
Functional Analysis of Nematode-Specific Genes using the Free-Living Nematode, Caenorhabditis elegans

Monday, April 11 | 2:30PM - 4:30PM
Workshop: RNAi/Transfections in Helminths

Speaker 6 of 9
Nicholas Patocka, McGill University, Canada
Cloning and Gene Silencing of a SERT – like Serotonin Transporter of Schistosoma Mansoni

Monday, April 11 | 2:30PM - 4:30PM
Workshop: RNAi/Transfections in Helminths

Speaker 7 of 9
Ahmed Abd El-Aziz Sayed, Illinois State University, USA
Validation by RNAi of Schistosoma mansoni Peroxiredoxins as Essential Parasite Proteins

Monday, April 11 | 2:30PM - 4:30PM
Workshop: RNAi/Transfections in Helminths

Speaker 8 of 9
Warwick N. Grant, New Zealand
Efficient RNA Inhibition in Trichostrongylus colubriformis

Monday, April 11 | 2:30PM - 4:30PM
Workshop: RNAi/Transfections in Helminths

Speaker 9 of 9
Bernd H. Kalinna, Germany
Structural Analysis of the Transcribed Sequence of Boudicca, a Schistosoma mansoni Retrotransposon

Monday, April 11 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Kokopelli's


Monday, April 11 | 5:00PM - 7:00PM
Signaling Pathways in Helminths
Room: Bighorn B

Speaker 1 of 4
* Philip T. LoVerde, University of Texas Health Science Center, USA
Nuclear Receptors in Schistosomes

Monday, April 11 | 5:00PM - 7:00PM
Signaling Pathways in Helminths
Room: Bighorn B

Speaker 2 of 4
Ahmed Osman Egiza, University at Buffalo, State University of New York, USA
Transforming Growth Factor-beta (TGF-beta) Signaling in Schistosoma mansoni

Monday, April 11 | 5:00PM - 7:00PM
Signaling Pathways in Helminths
Room: Bighorn B

Speaker 3 of 4
Colette Dissous, INSERM Institut Pasteur, France
Short Talk: Conservation and Divergence of Receptor Tyrosine Kinase Signaling in the Platyhelminth Schistosoma mansoni

Monday, April 11 | 5:00PM - 7:00PM
Signaling Pathways in Helminths
Room: Bighorn B

Speaker 4 of 4
Klaus Ruediger Brehm, Universität Würzburg, Germany
Signaling in Tapeworms

Monday, April 11 | 5:00PM - 7:15PM
Libraries and Screens
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 1 of 6
* Simon L. Croft, London School of Hygiene & Tropical Medicine, UK


Monday, April 11 | 5:00PM - 7:15PM
Libraries and Screens
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 2 of 6
Meg Phillips, University of Texas Southwestern Medical Center, USA
Targeting Plasmodium Dihydroorotate Dehydrogenase


Monday, April 11 | 5:00PM - 7:15PM
Libraries and Screens
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 3 of 6
Mary Ann Powles, Merck Research Laboratories, USA
Discovery of Anti-Infective Agents


Monday, April 11 | 5:00PM - 7:15PM
Libraries and Screens
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 4 of 6
Sean T. Prigge, Johns Hopkins Bloomberg School of Public Health, USA
Short Talk: Inhibition of Malaria Fatty Acid Biosynthesis: Targeting the beta-ketoacyl-ACP Synthase Enzymes


Monday, April 11 | 5:00PM - 7:15PM
Libraries and Screens
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 5 of 6
David A. Fidock, Columbia University Medical Center, USA
Short Talk: Inhibition of Plasmodium falciparum Enoyl ACP Reductase as a Target for Antimalarial Drug Development


Monday, April 11 | 5:00PM - 7:15PM
Libraries and Screens
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 6 of 6
Karl A. Werbovetz, Ohio State University, USA
Short Talk: Activity, Metabolism, and Pharmacokinetics of Antikinetoplastid Antimitotic N1,N4-substituted 3,5-Dinitro Sulfanilamides


Monday, April 11 | 7:00PM - 8:00PM
Social Hour
Room: Kokopelli's


Monday, April 11 | 7:30PM - 10:00PM
Poster Session 2
Room: Bighorn B


Tuesday, April 12 | 7:00AM - 8:00AM
Breakfast
Room: Ptarmigan


Tuesday, April 12 | 8:00AM - 11:15AM
Parasite Molecules that Modulate Host Immune Response
Room: Bighorn B

Speaker 1 of 6
* Maria Yazdanbakhsh, Leiden University Medical Center, Netherlands
The Immunoregulatory Network in Helminth Infections and the Lipid/Immune System Cross Talk

Tuesday, April 12 | 8:00AM - 11:15AM
Parasite Molecules that Modulate Host Immune Response
Room: Bighorn B

Speaker 2 of 6
Kalyanasundaram Ramaswamy, University of Illinois, USA
Schistosome-derived molecule in Host Immunoregulation

Tuesday, April 12 | 8:00AM - 11:15AM
Parasite Molecules that Modulate Host Immune Response
Room: Bighorn B

Speaker 3 of 6
William Harnett, Strathclyde Institute for Pharmacy and Biomedical Sciences, UK
Immunomodulatory Properties of the Filarial Nematode Secreted Product, ES-62

Tuesday, April 12 | 8:00AM - 11:15AM
Parasite Molecules that Modulate Host Immune Response
Room: Bighorn B

Speaker 4 of 6
Susanne Hartmann, Humboldt University at Berlin, Germany
Short Talk: Filarial tropomyosin: A Potential Allergen and Inducer of IL-10 via TLR-2 Signalling

Tuesday, April 12 | 8:00AM - 11:15AM
Parasite Molecules that Modulate Host Immune Response
Room: Bighorn B

Speaker 5 of 6
Malcolm W. Kennedy, University of Glasgow, UK
Short Talk: Atomic Structure and Function of the Polyprotein Allergens of Nematodes

Tuesday, April 12 | 8:00AM - 11:15AM
Parasite Molecules that Modulate Host Immune Response
Room: Bighorn B

Speaker 6 of 6
Alison M. Elliott, MRC/UVRI & LSHTM Uganda Research Unit, Uganda
Short Talk

Tuesday, April 12 | 8:00AM - 11:30AM
Inhibitor Design
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 1 of 8
* Wim G.J. Hol, University of Washington, USA


Tuesday, April 12 | 8:00AM - 11:30AM
Inhibitor Design
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 2 of 8
Ian H. Gilbert, University of Dundee, UK
Steroid Biosynthesis as a Drug Target in Parasitic Protozoa


Tuesday, April 12 | 8:00AM - 11:30AM
Inhibitor Design
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 3 of 8
Vern L. Schramm, Albert Einstein College of Medicine, USA
Exploiting the Unique Pathways for Purine and Polyamine Metabolism in Malaria


Tuesday, April 12 | 8:00AM - 11:30AM
Inhibitor Design
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 4 of 8
Lizbeth Hedstrom, Brandeis University, USA
IMP Dehydrogenase and the Dynamics of Drug Selectivity


Tuesday, April 12 | 8:00AM - 11:30AM
Inhibitor Design
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 5 of 8
Pradipsinh K. Rathod, University of Washington, USA
Drug-Induced Mutagenesis in Malaria


Tuesday, April 12 | 8:00AM - 11:30AM
Inhibitor Design
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 6 of 8
Amy C. Anderson, University of Connecticut, USA
Short Talk: A New Architecture for Bifunctional Dihydrofolate Reductase-Thymidylate Synthase: The Structure of the Enzyme from Cryptosporidium hominis


Tuesday, April 12 | 8:00AM - 11:30AM
Inhibitor Design
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 7 of 8
R. Kip Guy, St. Jude Children's Research Hospital, USA
Privileged Scaffold Discovery Libraries for Anti-Protozoan Drug Discovery


Tuesday, April 12 | 8:00AM - 11:30AM
Inhibitor Design
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 8 of 8
Frederick S. Buckner, University of Washington, USA
Short Talk: Protein Farnesyltransferase as a Target for Trypanosoma brucei Drug Development


Tuesday, April 12 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Tuesday, April 12 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Kokopelli's


Tuesday, April 12 | 5:00PM - 7:00PM
Contributions of Immune System to Helminth Development
Room: Bighorn B

Speaker 1 of 4
* James H. McKerrow, University of California, San Diego, USA
Factors Determining Schistosome Development in the Host Vasculature

Tuesday, April 12 | 5:00PM - 7:00PM
Contributions of Immune System to Helminth Development
Room: Bighorn B

Speaker 2 of 4
Isabelle Christiane Wolowczuk, Institut Pasteur / Institut de Biologie, France
Role of Interleukin-7 in Schistosome development

Tuesday, April 12 | 5:00PM - 7:00PM
Contributions of Immune System to Helminth Development
Room: Bighorn B

Speaker 3 of 4
Sheila M. Donnelly, University of Technology, Sydney, Australia
Short Talk: The Effect of Cathepsin L and Thioredoxin Peroxidase on Macrophages Promotes the Development of Th2 Responses during Infection with Fasciola hepatica

Tuesday, April 12 | 5:00PM - 7:00PM
Contributions of Immune System to Helminth Development
Room: Bighorn B

Speaker 4 of 4
Linda S. Mansfield, Michigan State University, USA
Short Talk

Tuesday, April 12 | 5:00PM - 7:00PM
Clinical Advances
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 1 of 4
* Terry Shapiro, Johns Hopkins University, USA


Tuesday, April 12 | 5:00PM - 7:00PM
Clinical Advances
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 2 of 4
Federico Gómez de las Heras, GlaxoSmithKline, Spain
Discovery of New Antimalarial Drugs


Tuesday, April 12 | 5:00PM - 7:00PM
Clinical Advances
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 3 of 4
Jonathan L. Vennerstrom, University of Nebraska Medical Center, USA
Synthetic Peroxides as Antimalarials


Tuesday, April 12 | 5:00PM - 7:00PM
Clinical Advances
This session is from Protozoan Parasites
Room: Bighorn C

Speaker 4 of 4
Christian Burri, Swiss Tropical Institute, Switzerland
Difficulties in the Conduct of Clinical Trials for Registration of New Drugs against Neglected Diseases in Africa


Tuesday, April 12 | 7:00PM - 8:00PM
Social Hour
Room: Ptarmigan Foyer


Tuesday, April 12 | 8:00PM - 11:00PM
Entertainment
Room: Ptarmigan


Tuesday, April 12 | 8:00PM - 11:00PM
Cash Bar
Room: Ptarmigan Foyer


Wednesday, April 13 | 10:26AM - 10:26AM
Departure


*Session Chair.