Web Desc
Drugs Against Protozoan Parasites: Target Selection, Structural Biology and Medicinal Chemistry
joint with Molecular Helminthology: An Integrated Approach
Organizer(s): Margaret A. Phillips, Pradipsinh K. Rathod and William N. Hunter
Date: April 09 - 13, 2005
Location: Copper Mountain Resort, Copper Mountain, CO, USA
Part of the Global Health Series, Supported by the Bill & Melinda Gates Foundation and Sponsored by the International Center for Tropical Disease Research
Summary of Meeting:
Appreciate important issues in parasite drug development: Hundreds of millions of people worldwide suffer from diseases caused by protozoan parasites. Effective drugs are lacking for sleeping sickness and leishmaniasis, and current therapies for treating malaria are at risk due to drug resistance. Thus, the development of new lines of anti-protozoan agents is urgently needed. With the sequencing of genomes of organisms responsible for malaria, sleeping sickness, and leishmaniasis, this is an exciting time for the discovery and evaluation of new drug targets, especially when combined with structural biology, combinatorial chemistry, and parasite genetics. Groups of talks, given by chemists, structural biologists, and parasitologists, will exemplify the power of multi-disciplinary collaborations. Experts in drug development outside of parasitology will also be invited in an effort to stimulate their interests in tropical medicine and to learn from their experiences.
Scholarship Deadline: December 8 2004
Discounted Abstract Deadline: December 8 2004
Discounted Registration Deadline: February 9 2005
We gratefully acknowledge additional support for this conference from:
Bill & Melinda Gates FoundationBurroughs Wellcome FundInstitute for OneWorld HealthInternational Center for Tropical Disease ResearchThe Ellison Medical Foundation
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

GlaxoSmithKline

Merck Research Laboratories
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 U13 AI60000-01

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13-AI063800-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Saturday, April 09 | 3:00PM - 7:30PM
Registration
Room: Kokopelli's


Saturday, April 09 | 6:30PM - 7:30PM
Refreshments
Room: Kokopelli's


Saturday, April 09 | 7:30PM - 8:30PM
Keynote Address
Room: Bighorn C

Speaker 1 of 1
Michael H. Gelb, University of Washington, USA
Protein Farnesyltransferase Inhibitors as Agents Against Malaria: Drug Development at Universities with Help from Industry

Sunday, April 10 | 7:00AM - 8:00AM
Breakfast
Room: Ptarmigan


Sunday, April 10 | 8:00AM - 11:15AM
Status of Helminth Genome Projects
This session is from Helminthology
Room: Bighorn B

Speaker 6 of 6
Fiona J. Thompson, University of Oxford, UK
Short Talk: An EST Analysis of the Life-Cycle of the Parasitic Nematode Strongyloides ratti


Sunday, April 10 | 8:00AM - 11:15AM
Status of Helminth Genome Projects
This session is from Helminthology
Room: Bighorn B

Speaker 5 of 6
Makedonka Mitreva, Washington University School of Medicine, USA
Investigating Hookworm Genomes by Comparative Analysis of Two Ancylostoma Species


Sunday, April 10 | 8:00AM - 11:15AM
Status of Helminth Genome Projects
This session is from Helminthology
Room: Bighorn B

Speaker 4 of 6
Barton E. Slatko, New England Biolabs, USA
The Genome of Wolbachia: A Parasite within the Human Filarial Parasite, Brugia malayi


Sunday, April 10 | 8:00AM - 11:15AM
Status of Helminth Genome Projects
This session is from Helminthology
Room: Bighorn B

Speaker 3 of 6
Elodie Ghedin, New York University, USA
Whole-Genome Analysis of the Parasitic Nematode Brugia malayi


Sunday, April 10 | 8:00AM - 11:15AM
Status of Helminth Genome Projects
This session is from Helminthology
Room: Bighorn B

Speaker 2 of 6
Matthew Berriman, Wellcome Sanger Institute, UK
Short Talk: The Schistosoma mansoni Genome Project at the Sanger Institute and access via SchistoDB


Sunday, April 10 | 8:00AM - 11:15AM
Status of Helminth Genome Projects
This session is from Helminthology
Room: Bighorn B

Speaker 1 of 6
* Najib M. El-Sayed, University of Maryland, USA
The Schistosoma mansoni Genome Project


Sunday, April 10 | 8:00AM - 11:15AM
Comparative Biology. Session Sponsored by The Ellison Medic
al Foundation

Room: Bighorn C

Speaker 7 of 7
Achim Schnaufer, University of Edinburgh, UK
Short Talk: RNA Editing as a Drug Target in Trypanosomatids

Sunday, April 10 | 8:00AM - 11:15AM
Comparative Biology. Session Sponsored by The Ellison Medic
al Foundation

Room: Bighorn C

Speaker 6 of 7
Tomoyoshi Nozaki, Gunma University Graduate School of Medicine, Japan
Short Talk: Sulfur-Containing Amino Acid Degradation as a Drug Target for Amebiasis: Biochemical and Structural analyses of Methionine gamma-Lyase from Entamoeba histolytica

Sunday, April 10 | 8:00AM - 11:15AM
Comparative Biology. Session Sponsored by The Ellison Medic
al Foundation

Room: Bighorn C

Speaker 5 of 7
William N. Hunter, University of Dundee, UK
Isoprenoid Biosynthetic Enzymes

Sunday, April 10 | 8:00AM - 11:15AM
Comparative Biology. Session Sponsored by The Ellison Medic
al Foundation

Room: Bighorn C

Speaker 4 of 7
Kasturi Haldar, University of Notre Dame, USA
Host-Pathogen Interactions as Targets in Malarial Infection

Sunday, April 10 | 8:00AM - 11:15AM
Comparative Biology. Session Sponsored by The Ellison Medic
al Foundation

Room: Bighorn C

Speaker 3 of 7
Daniel E. Goldberg, Washington University, USA
Plasmepsins as Antimalarial Targets

Sunday, April 10 | 8:00AM - 11:15AM
Comparative Biology. Session Sponsored by The Ellison Medic
al Foundation

Room: Bighorn C

Speaker 2 of 7
Alan H. Fairlamb, University of Dundee, UK
Enzymes of Trypanothione Metabolism

Sunday, April 10 | 8:00AM - 11:15AM
Comparative Biology. Session Sponsored by The Ellison Medic
al Foundation

Room: Bighorn C

Speaker 1 of 7
* Dyann F. Wirth, Harvard School of Public Health, USA

Sunday, April 10 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Sunday, April 10 | 11:15AM - 1:00PM
Poster Setup
Room: Bighorn


Sunday, April 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Bighorn


Sunday, April 10 | 2:30PM - 4:30PM
Workshop: Funding Opportunities
Room: Bighorn C

Speaker 4 of 6
Martin John Rogers, NIAID, National Institutes of Health, USA

Sunday, April 10 | 2:30PM - 4:30PM
Workshop: Funding Opportunities
Room: Bighorn C

Speaker 3 of 6
Solomon O. Nwaka, World Health Organization, Switzerland
Virtual Drug Discovery: lessons learned from public-private partnerships

Sunday, April 10 | 2:30PM - 4:30PM
Workshop: Funding Opportunities
Room: Bighorn C

Speaker 2 of 6
Robert Ridley, World Health Organization, Switzerland

Sunday, April 10 | 2:30PM - 4:30PM
Workshop: Funding Opportunities
Room: Bighorn C

Speaker 1 of 6
* Akhil B. Vaidya, Drexel University College of Medicine, USA

Sunday, April 10 | 2:30PM - 4:30PM
Workshop: Funding Opportunities
Room: Bighorn C

Speaker 5 of 6
Philip E. Coyne, Uniformed Services University of the Health Sciences, USA

Sunday, April 10 | 2:30PM - 4:30PM
Workshop: Funding Opportunities
Room: Bighorn C

Speaker 6 of 6
Simon L. Croft, London School of Hygiene & Tropical Medicine, UK

Sunday, April 10 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Kokopelli's


Sunday, April 10 | 5:00PM - 7:00PM
Functional Genomics
Room: Bighorn C

Speaker 1 of 6
* Stephen M. Beverley, Washington University School of Medicine, USA

Sunday, April 10 | 5:00PM - 7:00PM
Functional Genomics
Room: Bighorn C

Speaker 2 of 6
Brendan S. Crabb, Burnet Institute, Australia
The Plasmodium falciparum SERA Proteases are Novel Drug Targets

Sunday, April 10 | 5:00PM - 7:00PM
Functional Genomics
Room: Bighorn C

Speaker 3 of 6
Gary E. Ward, University of Vermont, USA
Using Small Molecules to Study Host Cell Invasion by T. gondii

Sunday, April 10 | 5:00PM - 7:00PM
Functional Genomics
Room: Bighorn C

Speaker 4 of 6
Elizabeth A. Winzeler, University of California, San Diego, USA
Short Talk: Systematic Determination of the Targets of Drug Resistance and Immunity

Sunday, April 10 | 5:00PM - 7:00PM
Functional Genomics
Room: Bighorn C

Speaker 5 of 6
Bo Wu, University of Pennsylvania, USA
Short Talk: Heme Metabolism in Apicomplexan Parasites

Sunday, April 10 | 5:00PM - 7:00PM
Functional Genomics
Room: Bighorn C

Speaker 6 of 6
Paul Hunt, University of Edinburgh, UK
Short Talk: Linkage Group Selection – A Rapid Molecular Genetics Strategy for Identifying loci Underlying Drug Resistance

Sunday, April 10 | 5:00PM - 7:00PM
Transcriptome and Proteome of Helminths
This session is from Helminthology
Room: Bighorn B

Speaker 1 of 5
* Karl F. Hoffmann, University of Cambridge, UK
Identifying Drug Targets From Transcriptome Analysis Of Schistosome Conjugal Biology


Sunday, April 10 | 5:00PM - 7:00PM
Transcriptome and Proteome of Helminths
This session is from Helminthology
Room: Bighorn B

Speaker 2 of 5
Peter Ashton, University of York, UK
Studies on the Schistosome Proteome


Sunday, April 10 | 5:00PM - 7:00PM
Transcriptome and Proteome of Helminths
This session is from Helminthology
Room: Bighorn B

Speaker 3 of 5
Cornelis H. Hokke, Leiden University Medical Center, Netherlands
Schistosome Glycoproteomics: Global Approaches - Detailed Findings


Sunday, April 10 | 5:00PM - 7:00PM
Transcriptome and Proteome of Helminths
This session is from Helminthology
Room: Bighorn B

Speaker 4 of 5
Ben-Wen Li, Washington University School of Medicine, USA
Short Talk: Profiling of Gender-Regulated Gene Transcripts in the Filarial Nematode Brugia malayi by cDNA Oligonucleotide Array Analysis


Sunday, April 10 | 5:00PM - 7:00PM
Transcriptome and Proteome of Helminths
This session is from Helminthology
Room: Bighorn B

Speaker 5 of 5
Steven A. Williams, Smith College, USA
Short Talk: An Update on the New Bruzui Malayi Microarray and other Resources Available through FR3


Sunday, April 10 | 7:00PM - 8:00PM
Social Hour
Room: Kokopelli's


Sunday, April 10 | 7:30PM - 10:00PM
Poster Session 1
Room: Bighorn C


Monday, April 11 | 7:00AM - 8:00AM
Breakfast
Room: Ptarmigan


Monday, April 11 | 8:00AM - 11:15AM
Established Drugs and Targets
Room: Bighorn C

Speaker 1 of 7
* James H. McKerrow, University of California, San Diego, USA

Monday, April 11 | 8:00AM - 11:15AM
Established Drugs and Targets
Room: Bighorn C

Speaker 2 of 7
Sanjeev Krishna, St. George's Hospital Medical School, UK
Artemisinin Targets

Monday, April 11 | 8:00AM - 11:15AM
Established Drugs and Targets
Room: Bighorn C

Speaker 3 of 7
Francisco Gamarro, Consejo Superior de Investigaciones Científicas, Spain
Mechanism of Miltefosine Resistance in Leishmania

Monday, April 11 | 8:00AM - 11:15AM
Established Drugs and Targets
Room: Bighorn C

Speaker 4 of 7
Stephen A. Ward, Liverpool School of Tropical Medicine, UK
Quinoline QSAR and Heme Access

Monday, April 11 | 8:00AM - 11:15AM
Established Drugs and Targets
Room: Bighorn C

Speaker 5 of 7
Paul D. Roepe, Georgetown University, USA
Analysis of Pfcrt Function: Toward a Molecular Understanding of Chloroquine Resistance

Monday, April 11 | 8:00AM - 11:15AM
Established Drugs and Targets
Room: Bighorn C

Speaker 6 of 7
Barry P. Rosen, Florida International University, USA
Short Talk: Pentostam Activation and Uptake in Leishmania major: Role of the Sb(V) Reductase LmAcr2 and the Aquaglyceroporin LmAqp1

Monday, April 11 | 8:00AM - 11:15AM
Established Drugs and Targets
Room: Bighorn C

Speaker 7 of 7
Maria Paola Costi, University of Modena and Reggio Emilia, Italy
Short Talk: Inhibition of the Folate Pathway in Parasites: Do Antifolates Still Work?

Monday, April 11 | 8:00AM - 11:15AM
Tools to Manipulate Helminth Gene Expression
This session is from Helminthology
Room: Bighorn B

Speaker 1 of 6
* Richard E. Davis, University of Colorado School of Medicine, USA
In vivo and in vitro Analysis of Gene Expression in Helminths


Monday, April 11 | 8:00AM - 11:15AM
Tools to Manipulate Helminth Gene Expression
This session is from Helminthology
Room: Bighorn B

Speaker 2 of 6
Timothy P. Yoshino, University of Wisconsin-Madison, USA
Gene “muffling” by RNAi in larval schistosomes: an effective functional genomics tool?


Monday, April 11 | 8:00AM - 11:15AM
Tools to Manipulate Helminth Gene Expression
This session is from Helminthology
Room: Bighorn B

Speaker 3 of 6
Christoph G. Grevelding, Institute for Parasitology, Germany
Short Talk: Transgenic Schistosomes: Progress and Challenges


Monday, April 11 | 8:00AM - 11:15AM
Tools to Manipulate Helminth Gene Expression
This session is from Helminthology
Room: Bighorn B

Speaker 4 of 6
Mark L. Blaxter, University of Edinburgh, UK
Comparative Nematode Genomics: Exploiting Expressed Sequence Tag and Genome Surveys of Nuclear and Symbiont Genomes


Monday, April 11 | 8:00AM - 11:15AM
Tools to Manipulate Helminth Gene Expression
This session is from Helminthology
Room: Bighorn B

Speaker 5 of 6
James B. Lok, University of Pennsylvania, USA
Transfection in Strongyloides


Monday, April 11 | 8:00AM - 11:15AM
Tools to Manipulate Helminth Gene Expression
This session is from Helminthology
Room: Bighorn B

Speaker 6 of 6
Sara Lustigman, New York Blood Center, USA
Short Talk: Cysteine Proteases of Filarial Nematodes: From Genome to Biology


Monday, April 11 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Monday, April 11 | 11:15AM - 1:00PM
Poster Setup
Room: Bighorn


Monday, April 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Bighorn


Monday, April 11 | 2:30PM - 4:30PM
Workshop: RNAi/Transfections in Helminths
This session is from Helminthology

Speaker 1 of 9
* Christoph G. Grevelding, Institute for Parasitology, Germany


Monday, April 11 | 2:30PM - 4:30PM
Workshop: RNAi/Transfections in Helminths
This session is from Helminthology

Speaker 2 of 9
* Sara Lustigman, New York Blood Center, USA


Monday, April 11 | 2:30PM - 4:30PM
Workshop: RNAi/Transfections in Helminths
This session is from Helminthology

Speaker 3 of 9
Karen L. Bennett, University of Missouri, USA
Cross-Species RNAi: Ascaris Genes Sterilize C. elegans


Monday, April 11 | 2:30PM - 4:30PM
Workshop: RNAi/Transfections in Helminths
This session is from Helminthology

Speaker 4 of 9
Jason M. Correnti, Thomas Jefferson University, USA
Longterm Suppression of Cathepsin B Levels by RNAi Retards Schistosome Growth


Monday, April 11 | 2:30PM - 4:30PM
Workshop: RNAi/Transfections in Helminths
This session is from Helminthology

Speaker 5 of 9
Julie-Anne Fritz, Australian National University, Australia
Functional Analysis of Nematode-Specific Genes using the Free-Living Nematode, Caenorhabditis elegans


Monday, April 11 | 2:30PM - 4:30PM
Workshop: RNAi/Transfections in Helminths
This session is from Helminthology

Speaker 6 of 9
Nicholas Patocka, McGill University, Canada
Cloning and Gene Silencing of a SERT – like Serotonin Transporter of Schistosoma Mansoni


Monday, April 11 | 2:30PM - 4:30PM
Workshop: RNAi/Transfections in Helminths
This session is from Helminthology

Speaker 7 of 9
Ahmed Abd El-Aziz Sayed, Illinois State University, USA
Validation by RNAi of Schistosoma mansoni Peroxiredoxins as Essential Parasite Proteins


Monday, April 11 | 2:30PM - 4:30PM
Workshop: RNAi/Transfections in Helminths
This session is from Helminthology

Speaker 8 of 9
Warwick N. Grant, New Zealand
Efficient RNA Inhibition in Trichostrongylus colubriformis


Monday, April 11 | 2:30PM - 4:30PM
Workshop: RNAi/Transfections in Helminths
This session is from Helminthology

Speaker 9 of 9
Bernd H. Kalinna, Germany
Structural Analysis of the Transcribed Sequence of Boudicca, a Schistosoma mansoni Retrotransposon


Monday, April 11 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Kokopelli's


Monday, April 11 | 5:00PM - 7:15PM
Libraries and Screens
Room: Bighorn C

Speaker 1 of 6
* Simon L. Croft, London School of Hygiene & Tropical Medicine, UK

Monday, April 11 | 5:00PM - 7:15PM
Libraries and Screens
Room: Bighorn C

Speaker 2 of 6
Meg Phillips, University of Texas Southwestern Medical Center, USA
Targeting Plasmodium Dihydroorotate Dehydrogenase

Monday, April 11 | 5:00PM - 7:15PM
Libraries and Screens
Room: Bighorn C

Speaker 3 of 6
Mary Ann Powles, Merck Research Laboratories, USA
Discovery of Anti-Infective Agents

Monday, April 11 | 5:00PM - 7:15PM
Libraries and Screens
Room: Bighorn C

Speaker 4 of 6
Sean T. Prigge, Johns Hopkins Bloomberg School of Public Health, USA
Short Talk: Inhibition of Malaria Fatty Acid Biosynthesis: Targeting the beta-ketoacyl-ACP Synthase Enzymes

Monday, April 11 | 5:00PM - 7:15PM
Libraries and Screens
Room: Bighorn C

Speaker 5 of 6
David A. Fidock, Columbia University Medical Center, USA
Short Talk: Inhibition of Plasmodium falciparum Enoyl ACP Reductase as a Target for Antimalarial Drug Development

Monday, April 11 | 5:00PM - 7:15PM
Libraries and Screens
Room: Bighorn C

Speaker 6 of 6
Karl A. Werbovetz, Ohio State University, USA
Short Talk: Activity, Metabolism, and Pharmacokinetics of Antikinetoplastid Antimitotic N1,N4-substituted 3,5-Dinitro Sulfanilamides

Monday, April 11 | 5:00PM - 7:00PM
Signaling Pathways in Helminths
This session is from Helminthology
Room: Bighorn B

Speaker 1 of 4
* Philip T. LoVerde, University of Texas Health Science Center, USA
Nuclear Receptors in Schistosomes


Monday, April 11 | 5:00PM - 7:00PM
Signaling Pathways in Helminths
This session is from Helminthology
Room: Bighorn B

Speaker 2 of 4
Ahmed Osman Egiza, University at Buffalo, State University of New York, USA
Transforming Growth Factor-beta (TGF-beta) Signaling in Schistosoma mansoni


Monday, April 11 | 5:00PM - 7:00PM
Signaling Pathways in Helminths
This session is from Helminthology
Room: Bighorn B

Speaker 3 of 4
Colette Dissous, INSERM Institut Pasteur, France
Short Talk: Conservation and Divergence of Receptor Tyrosine Kinase Signaling in the Platyhelminth Schistosoma mansoni


Monday, April 11 | 5:00PM - 7:00PM
Signaling Pathways in Helminths
This session is from Helminthology
Room: Bighorn B

Speaker 4 of 4
Klaus Ruediger Brehm, Universität Würzburg, Germany
Signaling in Tapeworms


Monday, April 11 | 7:00PM - 8:00PM
Social Hour
Room: Kokopelli's


Monday, April 11 | 7:30PM - 10:00PM
Poster Session 2
Room: Bighorn C


Tuesday, April 12 | 7:00AM - 8:00AM
Breakfast
Room: Ptarmigan


Tuesday, April 12 | 8:00AM - 11:30AM
Inhibitor Design
Room: Bighorn C

Speaker 1 of 8
* Wim G.J. Hol, University of Washington, USA

Tuesday, April 12 | 8:00AM - 11:30AM
Inhibitor Design
Room: Bighorn C

Speaker 2 of 8
Ian H. Gilbert, University of Dundee, UK
Steroid Biosynthesis as a Drug Target in Parasitic Protozoa

Tuesday, April 12 | 8:00AM - 11:30AM
Inhibitor Design
Room: Bighorn C

Speaker 3 of 8
Vern L. Schramm, Albert Einstein College of Medicine, USA
Exploiting the Unique Pathways for Purine and Polyamine Metabolism in Malaria

Tuesday, April 12 | 8:00AM - 11:30AM
Inhibitor Design
Room: Bighorn C

Speaker 4 of 8
Lizbeth Hedstrom, Brandeis University, USA
IMP Dehydrogenase and the Dynamics of Drug Selectivity

Tuesday, April 12 | 8:00AM - 11:30AM
Inhibitor Design
Room: Bighorn C

Speaker 5 of 8
Pradipsinh K. Rathod, University of Washington, USA
Drug-Induced Mutagenesis in Malaria

Tuesday, April 12 | 8:00AM - 11:30AM
Inhibitor Design
Room: Bighorn C

Speaker 6 of 8
Amy C. Anderson, University of Connecticut, USA
Short Talk: A New Architecture for Bifunctional Dihydrofolate Reductase-Thymidylate Synthase: The Structure of the Enzyme from Cryptosporidium hominis

Tuesday, April 12 | 8:00AM - 11:30AM
Inhibitor Design
Room: Bighorn C

Speaker 7 of 8
R. Kip Guy, St. Jude Children's Research Hospital, USA
Privileged Scaffold Discovery Libraries for Anti-Protozoan Drug Discovery

Tuesday, April 12 | 8:00AM - 11:30AM
Inhibitor Design
Room: Bighorn C

Speaker 8 of 8
Frederick S. Buckner, University of Washington, USA
Short Talk: Protein Farnesyltransferase as a Target for Trypanosoma brucei Drug Development

Tuesday, April 12 | 8:00AM - 11:15AM
Parasite Molecules that Modulate Host Immune Response
This session is from Helminthology
Room: Bighorn B

Speaker 1 of 6
* Maria Yazdanbakhsh, Leiden University Medical Center, Netherlands
The Immunoregulatory Network in Helminth Infections and the Lipid/Immune System Cross Talk


Tuesday, April 12 | 8:00AM - 11:15AM
Parasite Molecules that Modulate Host Immune Response
This session is from Helminthology
Room: Bighorn B

Speaker 2 of 6
Kalyanasundaram Ramaswamy, University of Illinois, USA
Schistosome-derived molecule in Host Immunoregulation


Tuesday, April 12 | 8:00AM - 11:15AM
Parasite Molecules that Modulate Host Immune Response
This session is from Helminthology
Room: Bighorn B

Speaker 3 of 6
William Harnett, Strathclyde Institute for Pharmacy and Biomedical Sciences, UK
Immunomodulatory Properties of the Filarial Nematode Secreted Product, ES-62


Tuesday, April 12 | 8:00AM - 11:15AM
Parasite Molecules that Modulate Host Immune Response
This session is from Helminthology
Room: Bighorn B

Speaker 4 of 6
Susanne Hartmann, Humboldt University at Berlin, Germany
Short Talk: Filarial tropomyosin: A Potential Allergen and Inducer of IL-10 via TLR-2 Signalling


Tuesday, April 12 | 8:00AM - 11:15AM
Parasite Molecules that Modulate Host Immune Response
This session is from Helminthology
Room: Bighorn B

Speaker 5 of 6
Malcolm W. Kennedy, University of Glasgow, UK
Short Talk: Atomic Structure and Function of the Polyprotein Allergens of Nematodes


Tuesday, April 12 | 8:00AM - 11:15AM
Parasite Molecules that Modulate Host Immune Response
This session is from Helminthology
Room: Bighorn B

Speaker 6 of 6
Alison M. Elliott, MRC/UVRI & LSHTM Uganda Research Unit, Uganda
Short Talk


Tuesday, April 12 | 9:20AM - 9:40AM
Coffee Break
Room: Kokopelli's


Tuesday, April 12 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Kokopelli's


Tuesday, April 12 | 5:00PM - 7:00PM
Clinical Advances
Room: Bighorn C

Speaker 1 of 4
* Terry Shapiro, Johns Hopkins University, USA

Tuesday, April 12 | 5:00PM - 7:00PM
Clinical Advances
Room: Bighorn C

Speaker 2 of 4
Federico Gómez de las Heras, GlaxoSmithKline, Spain
Discovery of New Antimalarial Drugs

Tuesday, April 12 | 5:00PM - 7:00PM
Clinical Advances
Room: Bighorn C

Speaker 3 of 4
Jonathan L. Vennerstrom, University of Nebraska Medical Center, USA
Synthetic Peroxides as Antimalarials

Tuesday, April 12 | 5:00PM - 7:00PM
Clinical Advances
Room: Bighorn C

Speaker 4 of 4
Christian Burri, Swiss Tropical Institute, Switzerland
Difficulties in the Conduct of Clinical Trials for Registration of New Drugs against Neglected Diseases in Africa

Tuesday, April 12 | 5:00PM - 7:00PM
Contributions of Immune System to Helminth Development
This session is from Helminthology
Room: Bighorn B

Speaker 1 of 4
* James H. McKerrow, University of California, San Diego, USA
Factors Determining Schistosome Development in the Host Vasculature


Tuesday, April 12 | 5:00PM - 7:00PM
Contributions of Immune System to Helminth Development
This session is from Helminthology
Room: Bighorn B

Speaker 2 of 4
Isabelle Christiane Wolowczuk, Institut Pasteur / Institut de Biologie, France
Role of Interleukin-7 in Schistosome development


Tuesday, April 12 | 5:00PM - 7:00PM
Contributions of Immune System to Helminth Development
This session is from Helminthology
Room: Bighorn B

Speaker 3 of 4
Sheila M. Donnelly, University of Technology, Sydney, Australia
Short Talk: The Effect of Cathepsin L and Thioredoxin Peroxidase on Macrophages Promotes the Development of Th2 Responses during Infection with Fasciola hepatica


Tuesday, April 12 | 5:00PM - 7:00PM
Contributions of Immune System to Helminth Development
This session is from Helminthology
Room: Bighorn B

Speaker 4 of 4
Linda S. Mansfield, Michigan State University, USA
Short Talk


Tuesday, April 12 | 7:00PM - 8:00PM
Social Hour
Room: Ptarmigan Foyer


Tuesday, April 12 | 8:00PM - 11:00PM
Entertainment
Room: Ptarmigan


Tuesday, April 12 | 8:00PM - 11:00PM
Cash Bar
Room: Ptarmigan Foyer


Wednesday, April 13 | 10:26AM - 10:26AM
Departure


*Session Chair.