Web Desc
PPAR/LXR
joint with Bioactive Lipids, Lipidomics and their Targets
Organizer(s): Christopher Glass and Mitchell A. Lazar
Date: April 12 - 17, 2005
Location: Fairmont Chateau Whistler, Whistler, BC, Canada
Part of the Translational Medicine Series, Supported by Pfizer Global Research and Development
Summary of Meeting:
The accelerating incidence of obesity, insulin resistance and hyperlipidemia in Westernized societies and the attendant complications of diabetes and atherosclerosis is fueling an explosion of interest in the molecular mechanisms underlying metabolic disease. The PPAR subfamily of nuclear receptors, consisting of PPARa, PPARg, and PPARd, initially became the focus of intense investigation following discoveries of roles of PPARa and PPARg in controlling aspects of lipid and glucose homeostasis. PPARs regulate programs of gene expression by functioning as ligand-dependent transcription factors. Although the range of physiological ligands that regulate the activities of each PPAR in vivo remain to be clearly defined, PPARa and PPARg are the molecular targets of fibrates and thiazolidinediones that were identified empirically to lower circulating triglyceride levels and to improve insulin resistance in diabetic patients, respectively. The recognition that these classes of drugs exert their therapeutic effects by binding to PPARa and PPARg suggests that more effective drugs for the treatment of hyperlipidemia and type 2 diabetes can be developed by optimizing ligand-receptor interactions. Furthermore, recent studies have suggested additional roles of PPARs in a diverse range of physiological and pathophysiological settings, including vascular wall biology, placental physiology, atherosclerosis, inflammatory bowel and skin disorders, metabolic bone disease and cancer. Further exploration of these observations should expand our general understanding of important developmental and homeostatic processes at a molecular level, and may lead to new avenues of therapeutic intervention in common human diseases. Because of the potential biomedical significance of this field of research, studies of PPAR-related processes have resulted in a number of pioneering discoveries of general importance to molecular biology and development. In concert with recent developments in the PPAR field, a parallel of series of discoveries has emerged relating to regulation of cholesterol and triglyceride homeostasis by the LXR subfamily of nuclear receptors, consisting of LXRa and LXRb. The LXRs are activated by cholesterol metabolites and provide the basis for a feed-forward homeostatic control circuit for maintenance of cellular cholesterol levels. The biological actions of LXRs relate in part to their ability to regulate members of the ABC family of lipid transporters, including ABC A1 and ABC G1, which mediate the efflux of cholesterol from cells. These findings raise the possibility that new classes of cholesterol lowering drugs could be developed that would work synergistically with currently available agents. These considerations justify a Keystone Conference focused on PPARs and LXRs in 2005. The PPAR field is entering a new wave of discovery based on the recent success in generating conditional experimental systems for analysis of PPARg and PPARd-null mice. Studies for metabolic pathways regulated for PPARs and LXRs are also benefiting from the application of increasingly powerful genomics and proteomics tools. A 2005 Keystone Meeting on PPARs and LXRs will be well timed to bring together a diverse array of investigators from academia and industry to synthesize the most recent developments and define future directions. This meeting will also provide opportunities to highlight major findings from studies of less well-characterized members of the nuclear receptor family that have recently emerged as potential regulators of lipid metabolism and energy homeostasis, such as FXR. Finally, this meeting will continue to be a valuable opportunity for trainees to present work in a poster session, meet leaders in the field, and explore opportunities for future career development.
Discounted Abstract Deadline: December 13 2004
Discounted Registration Deadline: February 14 2005
We gratefully acknowledge additional support for this conference from:
Pfizer Global Research & Development
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Exelixis, Inc.

GlaxoSmithKline

Merck Research Laboratories
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1R13-DK070428-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, April 12 | 3:00PM - 7:30PM
Registration
Room: Macdonald Foyer


Tuesday, April 12 | 6:30PM - 7:30PM
Refreshments
Room: Macdonald Foyer


Tuesday, April 12 | 7:30PM - 8:30PM
Keynote Address (Joint)
Room: MacDonald ABC

Speaker 1 of 3
* Garret A. FitzGerald, University of Pennsylvania, USA

Tuesday, April 12 | 7:30PM - 8:30PM
Keynote Address (Joint)
Room: MacDonald ABC

Speaker 2 of 3
* Christopher K. Glass, University of California, San Diego, USA

Tuesday, April 12 | 7:30PM - 8:30PM
Keynote Address (Joint)
Room: MacDonald ABC

Speaker 3 of 3
Cynthia Kenyon, Calico, USA
Aging and Metabolism: Lessons from C. elegans

Wednesday, April 13 | 7:00AM - 8:00AM
Breakfast
Room: MacDonald DEF


Wednesday, April 13 | 8:00AM - 11:15AM
Lipid Ligands and Nuclear Receptors (Joint)
Room: MacDonald ABC

Speaker 1 of 7
* Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA

Wednesday, April 13 | 8:00AM - 11:15AM
Lipid Ligands and Nuclear Receptors (Joint)
Room: MacDonald ABC

Speaker 2 of 7
Ronald M. Evans, HHMI/The Salk Institute, USA
PPARs at the Nexus of Inflammation and Metabolism

Wednesday, April 13 | 8:00AM - 11:15AM
Lipid Ligands and Nuclear Receptors (Joint)
Room: MacDonald ABC

Speaker 3 of 7
David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA
The Contrasting Roles of LXRs and FXR in Lipid Metabolism

Wednesday, April 13 | 8:00AM - 11:15AM
Lipid Ligands and Nuclear Receptors (Joint)
Room: MacDonald ABC

Speaker 4 of 7
H. Alex Brown, Vanderbilt University, USA
Lipids and Signaling Networks

Wednesday, April 13 | 8:00AM - 11:15AM
Lipid Ligands and Nuclear Receptors (Joint)
Room: MacDonald ABC

Speaker 5 of 7
Beverly Koller, University of North Carolina at Chapel Hill, USA
Eiscosanoids and Related Products in Inflammation

Wednesday, April 13 | 8:00AM - 11:15AM
Lipid Ligands and Nuclear Receptors (Joint)
Room: MacDonald ABC

Speaker 6 of 7
Barry Marc Forman, City of Hope, USA
Short Talk: Identifying True Endogenous Ligands for Lipid Receptors

Wednesday, April 13 | 8:00AM - 11:15AM
Lipid Ligands and Nuclear Receptors (Joint)
Room: MacDonald ABC

Speaker 7 of 7
Naoka Murakami, Brigham and Women's Hospital, USA
Short Talk: G2A is a Proton-Sensing G-Protein Coupled Receptor, Antagonized by Lysophosphatidylcholine

Wednesday, April 13 | 9:20AM - 9:40AM
Coffee Break
Room: Macdonald Foyer


Wednesday, April 13 | 11:15AM - 1:00PM
Poster Setup
Room: Macdonald DEF


Wednesday, April 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Macdonald DEF


Wednesday, April 13 | 3:00PM - 4:30PM
Workshop 1: Hot Topics/Lipid Receptors
Room: MacDonald BC

Speaker 1 of 10
* Richard A. Heyman, ORIC Pharmaceuticals, USA

Wednesday, April 13 | 3:00PM - 4:30PM
Workshop 1: Hot Topics/Lipid Receptors
Room: MacDonald BC

Speaker 2 of 10
* Barry Marc Forman, City of Hope, USA

Wednesday, April 13 | 3:00PM - 4:30PM
Workshop 1: Hot Topics/Lipid Receptors
Room: MacDonald BC

Speaker 3 of 10
Thomas P. Burris, Washington University School of Medicine, USA
Regulation of Carbohydrate Metabolism by the Farnesoid X Receptor

Wednesday, April 13 | 3:00PM - 4:30PM
Workshop 1: Hot Topics/Lipid Receptors
Room: MacDonald BC

Speaker 4 of 10
Jason M. Held, Washington University in St. Louis, USA
Progress on Identifying the Endogenous Ligand of DAF-12, an Orphan Nuclear Receptor in C. elegans

Wednesday, April 13 | 3:00PM - 4:30PM
Workshop 1: Hot Topics/Lipid Receptors
Room: MacDonald BC

Speaker 5 of 10
Darja Debevec, Institute of Reproductive and Developmental Biology, UK
Repression of Nuclear Receptor Regulated Genes by RIP140 Controls Adipocyte Function

Wednesday, April 13 | 3:00PM - 4:30PM
Workshop 1: Hot Topics/Lipid Receptors
Room: MacDonald BC

Speaker 6 of 10
Seung-Whan Kim, University of Ulsan, South Korea
Regulation of Insulin Secretion and beta-cell Mass by Activating Signal Cointegrator-2

Wednesday, April 13 | 3:00PM - 4:30PM
Workshop 1: Hot Topics/Lipid Receptors
Room: MacDonald BC

Speaker 7 of 10
Yejun Tan, Rosetta Inpharmatics LLC, USA
An Adipocyte Transcriptosome-Based PPARgamma Activation Index that Discriminates between Full Agonists and SPPARgammaMs

Wednesday, April 13 | 3:00PM - 4:30PM
Workshop 1: Hot Topics/Lipid Receptors
Room: MacDonald BC

Speaker 8 of 10
Aixue Liu, GlaxoSmithKline Pharmaceuticals, USA
Laser Capture Micro-Dissection (LCM) Based Gene Expression Analysis Reveals Decreased PGC-1 Expression in Slow Fibers of db/db Mice Skeletal Muscle

Wednesday, April 13 | 3:00PM - 4:30PM
Workshop 1: Hot Topics/Lipid Receptors
Room: MacDonald BC

Speaker 9 of 10
Toshiya Tanaka, University of Tokyo, Japan
Peroxisome Proliferator-Activated Receptor delta (PPARdelta) Agonist Improves Adipocytokine Production and Prevents High Fat Diet Induced Obesity and Insulin Resistance with Long-Term Efficacy

Wednesday, April 13 | 3:00PM - 4:30PM
Workshop 1: Hot Topics/Lipid Receptors
Room: MacDonald BC

Speaker 10 of 10
Knut R. Steffensen, Karolinska Institute, Sweden
Genome Wide Expression Profiling; A Panel of Mouse Tissues Discloses Novel Biological Functions of LXRs In Adrenals

Wednesday, April 13 | 3:00PM - 4:45PM
Workshop 1: Hot Topics/Lipids
This session is from Lipids
Room: MacDonald A

Speaker 1 of 4
* Ian A. Blair, University of Pennsylvania, USA
Lipidomics and Proteomics in Cancer


Wednesday, April 13 | 3:00PM - 4:45PM
Workshop 1: Hot Topics/Lipids
This session is from Lipids
Room: MacDonald A

Speaker 2 of 4
William L. Smith, University of Michigan, USA
PGH Synthases: Peroxidase Substrate Specificity and Eicosapentaenoic Acid Oxygenation


Wednesday, April 13 | 3:00PM - 4:45PM
Workshop 1: Hot Topics/Lipids
This session is from Lipids
Room: MacDonald A

Speaker 3 of 4
Timothy T. Hla, Boston Children's Hospital/Harvard Medical School, USA
Sphingosine 1-Phosphate Signaling: to the Vascular System and Beyond


Wednesday, April 13 | 3:00PM - 4:45PM
Workshop 1: Hot Topics/Lipids
This session is from Lipids
Room: MacDonald A

Speaker 4 of 4
Christer S. Ejsing, MPI of Molecular Cell Biology and Genetics, Germany
Short Talk: Shotgun Lipidomics - Unleashing the Power of Mass Spectrometric Lipid Analysis


Wednesday, April 13 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Macdonald Foyer


Wednesday, April 13 | 5:00PM - 7:00PM
Molecular Mechanisms
Room: MacDonald BC

Speaker 1 of 4
Myles Brown, Dana-Farber Cancer Institute, USA
Chromosome-Scale Analysis of Nuclear Receptor Action

Wednesday, April 13 | 5:00PM - 7:00PM
Molecular Mechanisms
Room: MacDonald BC

Speaker 2 of 4
* Janardan K. Reddy, Northwestern University Medical School, USA
Nuclear Receptor Coactivators in PPAR Action

Wednesday, April 13 | 5:00PM - 7:00PM
Molecular Mechanisms
Room: MacDonald BC

Speaker 3 of 4
Timothy M. Willson, GlaxoSmithKline, USA
Characterization of PPARgamma Modulators Derived from Structure-Guided Synthesis

Wednesday, April 13 | 5:00PM - 7:00PM
Molecular Mechanisms
Room: MacDonald BC

Speaker 4 of 4
Pere Puigserver, Dana-Farber Cancer Institute, Harvard Medical School, USA
Short Talk: Nutrient Control of Glucose Metabolism Through PGC-1alpha/SIRT1 Complex

Wednesday, April 13 | 5:00PM - 7:30PM
Lipids and their Enzymes
This session is from Lipids
Room: MacDonald A

Speaker 1 of 5
* Michal L. Schwartzman, New York Medical College, USA
Cytochrome P450 Products of Arachidonic Acid in Renal and Cardiovascular Function


Wednesday, April 13 | 5:00PM - 7:30PM
Lipids and their Enzymes
This session is from Lipids
Room: MacDonald A

Speaker 2 of 5
Steven A. Farber, Carnegie Institution of Washington, USA
Visualizing Lipid Metabolism and Germ Cell Migration in Live Zebrafish:A Genetic Screen With Guts


Wednesday, April 13 | 5:00PM - 7:30PM
Lipids and their Enzymes
This session is from Lipids
Room: MacDonald A

Speaker 3 of 5
Colin D. Funk, Queen's University, Canada
Novel Mouse Models for Elucidating Eicosanoid Functions


Wednesday, April 13 | 5:00PM - 7:30PM
Lipids and their Enzymes
This session is from Lipids
Room: MacDonald A

Speaker 4 of 5
Roy J. Soberman, Harvard Medical School, USA
The Membrane Organization of Leukotriene Synthesis


Wednesday, April 13 | 5:00PM - 7:30PM
Lipids and their Enzymes
This session is from Lipids
Room: MacDonald A

Speaker 5 of 5
H. Eric Xu, Van Andel Institute, USA
Short Talk: Structural and Functional Identification of Phospholipids as Ligands for the Orphan Nuclear Receptor Steroidogenic Factor-1


Wednesday, April 13 | 7:00PM - 8:00PM
Social Hour
Room: Macdonald Foyer


Wednesday, April 13 | 7:30PM - 10:00PM
Poster Session 1
Room: Macdonald DEF


Thursday, April 14 | 7:00AM - 8:00AM
Breakfast
Room: MacDonald DEF


Thursday, April 14 | 8:00AM - 11:00AM
Metabolic Disease (Joint)
Room: MacDonald ABC

Speaker 1 of 7
* Bruce M. Spiegelman, Harvard Medical School, USA

Thursday, April 14 | 8:00AM - 11:00AM
Metabolic Disease (Joint)
Room: MacDonald ABC

Speaker 2 of 7
* Timothy T. Hla, Boston Children's Hospital/Harvard Medical School, USA

Thursday, April 14 | 8:00AM - 11:00AM
Metabolic Disease (Joint)
Room: MacDonald ABC

Speaker 3 of 7
Takashi Kadowaki, University of Tokyo, Japan
Adiponectin and PPARs in the Metabolic Syndrome

Thursday, April 14 | 8:00AM - 11:00AM
Metabolic Disease (Joint)
Room: MacDonald ABC

Speaker 4 of 7
Bruce M. Spiegelman, Harvard Medical School, USA
The PGC-1 Coactivators and the Control of Lipid Metabolism

Thursday, April 14 | 8:00AM - 11:00AM
Metabolic Disease (Joint)
Room: MacDonald ABC

Speaker 5 of 7
Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Selective Modulation of PPAR and LXR By Nuclear Receptor Corepressors

Thursday, April 14 | 8:00AM - 11:00AM
Metabolic Disease (Joint)
Room: MacDonald ABC

Speaker 6 of 7
Richard A. Heyman, ORIC Pharmaceuticals, USA
Short Talk: LXR and FXR; Drug Targets for Metabolic Syndrome

Thursday, April 14 | 8:00AM - 11:00AM
Metabolic Disease (Joint)
Room: MacDonald ABC

Speaker 7 of 7
Gerhard Liebisch, University of Regensburg, Germany
Short Talk: Analysis of the Cellular Lipid Metabolism upon Cholesterol Loading using a Combination of Lipid Metabolic Profiling by ESI-MS/MS and mRNA Expression Analysis

Thursday, April 14 | 9:20AM - 9:40AM
Coffee Break
Room: Macdonald Foyer


Thursday, April 14 | 11:00AM - 1:00PM
Poster Setup
Room: Macdonald DEF


Thursday, April 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Macdonald DEF


Thursday, April 14 | 3:00PM - 4:30PM
Workshop 2: Hot Topics
Room: MacDonald BC

Speaker 1 of 10
* Hilde Irene Nebb, University of Oslo, Norway

Thursday, April 14 | 3:00PM - 4:30PM
Workshop 2: Hot Topics
Room: MacDonald BC

Speaker 2 of 10
* Jorge Plutzky, Brigham and Women's Hospital, USA

Thursday, April 14 | 3:00PM - 4:30PM
Workshop 2: Hot Topics
Room: MacDonald BC

Speaker 3 of 10
Grant D. Barish, The Salk Institute, USA
A Nuclear Receptor Atlas: Macrophage Activation

Thursday, April 14 | 3:00PM - 4:30PM
Workshop 2: Hot Topics
Room: MacDonald BC

Speaker 4 of 10
Michelle N. Bradley, University of California, Los Angeles, USA
LXR-Dependent Gene Expression is Important for Macrophage Survival and the Innate Immune Response

Thursday, April 14 | 3:00PM - 4:30PM
Workshop 2: Hot Topics
Room: MacDonald BC

Speaker 5 of 10
Brian N. Finck, Washington University School of Medicine, USA
Lipin 1 Is A Fasting-Induced PGC-1a Target Gene Upstream of PPARa

Thursday, April 14 | 3:00PM - 4:30PM
Workshop 2: Hot Topics
Room: MacDonald BC

Speaker 6 of 10
Michael Lehrke, Klinikum Grosshadern, Germany
Diet-Dependent Cardiovascular Lipid Metabolism Controlled by Hepatic LXRá

Thursday, April 14 | 3:00PM - 4:30PM
Workshop 2: Hot Topics
Room: MacDonald BC

Speaker 7 of 10
Ji Miao, USA
The Xenobiotic Nuclear Receptors CAR and PXR Inhibit HNF-4 Signaling in Cholesterol and Glucose Metabolism

Thursday, April 14 | 3:00PM - 4:30PM
Workshop 2: Hot Topics
Room: MacDonald BC

Speaker 8 of 10
Ronni Nielsen, University of Southern Denmark, Denmark
Molecular Mechanisms of PPAR Subtype Specific Activation of Chromatin-Embedded Target Genes

Thursday, April 14 | 3:00PM - 4:30PM
Workshop 2: Hot Topics
Room: MacDonald BC

Speaker 9 of 10
David Alexander Sarruf, Novo Nordisk, Denmark
Cyclin D3 Promotes Adipogenesis through PPARg Activation

Thursday, April 14 | 3:00PM - 4:30PM
Workshop 2: Hot Topics
Room: MacDonald BC

Speaker 10 of 10
Attila Szanto, Massachusetts General Hospital, USA
Role of PPAR-gamma in Differently Activated Macrophages

Thursday, April 14 | 3:00PM - 4:45PM
Workshop 2: Hot Topics/Lipids
This session is from Lipids
Room: MacDonald A

Speaker 1 of 4
* Robert F. Klein, Oregon Health & Science University, USA
Lipoxygenase and Skelatal Health


Thursday, April 14 | 3:00PM - 4:45PM
Workshop 2: Hot Topics/Lipids
This session is from Lipids
Room: MacDonald A

Speaker 2 of 4
Robert C. Murphy, University of Colorado Denver, USA
Mass Spectrometry of Lipids: Qualitative and Quantitative Approaches for RAW Cells


Thursday, April 14 | 3:00PM - 4:45PM
Workshop 2: Hot Topics/Lipids
This session is from Lipids
Room: MacDonald A

Speaker 3 of 4
Claudio Sturino, Merck Frosst Centre for Therapeutic Research, Canada
BP Program


Thursday, April 14 | 3:00PM - 4:45PM
Workshop 2: Hot Topics/Lipids
This session is from Lipids
Room: MacDonald A

Speaker 4 of 4
Anne-Maria Curtis, University of Pennsylvania, USA
Short Talk: Blood Pressure and the Molecular Clock


Thursday, April 14 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Macdonald Foyer


Thursday, April 14 | 5:00PM - 7:00PM
Adipogenesis/Energy Homeostasis
Room: MacDonald BC

Speaker 1 of 4
* Stephen R. Farmer, Boston University School of Medicine, USA
Molecular Mechanisms Regulating Adipogenesis: Interplay between PPARgamma and C/EBPalpha

Thursday, April 14 | 5:00PM - 7:00PM
Adipogenesis/Energy Homeostasis
Room: MacDonald BC

Speaker 2 of 4
Frank J. Gonzalez, National Institutes of Health, USA
Mice Humanized for PPARalpha are Resistant to the Hepatocarcinogenic Effects of Peroxisome Proliferators

Thursday, April 14 | 5:00PM - 7:00PM
Adipogenesis/Energy Homeostasis
Room: MacDonald BC

Speaker 3 of 4
David E. Moller, Eli Lilly and Company, USA
Novel PPARgamma Ligands and Mechanisms of Insulin Sensitization

Thursday, April 14 | 5:00PM - 7:00PM
Adipogenesis/Energy Homeostasis
Room: MacDonald BC

Speaker 4 of 4
Hilde Irene Nebb, University of Oslo, Norway
Short Talk: LXR in Metabolic Control

Thursday, April 14 | 5:00PM - 7:00PM
Lipidomics and Proteomics
This session is from Lipids
Room: MacDonald A

Speaker 1 of 5
* Edward A. Dennis, University of California, San Diego, USA
The Lipid Maps Consortium


Thursday, April 14 | 5:00PM - 7:00PM
Lipidomics and Proteomics
This session is from Lipids
Room: MacDonald A

Speaker 2 of 5
Xianlin Han, Sanford Burnham Medical Research Institute, USA
Shotgun Lipidomics Based on Intrasource Separation and Multidimensional Mass Spectrometry: Principles and Applications


Thursday, April 14 | 5:00PM - 7:00PM
Lipidomics and Proteomics
This session is from Lipids
Room: MacDonald A

Speaker 3 of 5
Hee-Yong Kim, National Institutes of Health, USA
Membrane Modification Characterized by Liquid Chromatography/Mass Spectrometry: Implication in Cell Signaling


Thursday, April 14 | 5:00PM - 7:00PM
Lipidomics and Proteomics
This session is from Lipids
Room: MacDonald A

Speaker 4 of 5
Lawrence M. Sayre, Case Western Reserve University, USA
Protein Side-Chain Modification by Aldehyde Products of Lipid Oxidation


Thursday, April 14 | 5:00PM - 7:00PM
Lipidomics and Proteomics
This session is from Lipids
Room: MacDonald A

Speaker 5 of 5
Kim Ekroos, Lipidomics Consulting Ltd., Finland
Short Talk: Unravelling Phospholipidomes by Shotgun Lipidomics


Thursday, April 14 | 7:00PM - 8:00PM
Social Hour
Room: Macdonald Foyer


Thursday, April 14 | 7:30PM - 10:00PM
Poster Session 2
Room: Macdonald DEF


Friday, April 15 | 7:00AM - 8:00AM
Breakfast
Room: MacDonald DEF


Friday, April 15 | 8:00AM - 11:15AM
Inflammation (Joint)
Room: MacDonald ABC

Speaker 1 of 7
* Carlo Patrono, University of Rome, Italy

Friday, April 15 | 8:00AM - 11:15AM
Inflammation (Joint)
Room: MacDonald ABC

Speaker 2 of 7
Beatrice Desvergne, University of Lausanne, Switzerland
PPARs: Beyond the Cardiovascular Therapeutic Applications

Friday, April 15 | 8:00AM - 11:15AM
Inflammation (Joint)
Room: MacDonald ABC

Speaker 3 of 7
Peter Tontonoz, University of California, Los Angeles, USA
Nuclear Receptors at the Crossroads of Lipid Metabolism and Inflammation in Macrophages

Friday, April 15 | 8:00AM - 11:15AM
Inflammation (Joint)
Room: MacDonald ABC

Speaker 4 of 7
* Christopher K. Glass, University of California, San Diego, USA
Regulation of Macrophage Foam Cell Formation and Inflammatory Gene Expression by PPARs

Friday, April 15 | 8:00AM - 11:15AM
Inflammation (Joint)
Room: MacDonald ABC

Speaker 5 of 7
Garret A. FitzGerald, University of Pennsylvania, USA
The Collapse of the Coxibs; Challenges and Opportunities in the
Arachidonic Acid Cascade


Friday, April 15 | 8:00AM - 11:15AM
Inflammation (Joint)
Room: MacDonald ABC

Speaker 6 of 7
Laszlo Nagy, Sanford-Burnham Medical Research Institute at Lake Nona, USA
Short Talk: PPARg in Antigen Presenting Cells Regulates Lipid Metabolism and Inflammatory Response

Friday, April 15 | 8:00AM - 11:15AM
Inflammation (Joint)
Room: MacDonald ABC

Speaker 7 of 7
Ajay Chawla, Merck Research Labs, USA
Short Talk: PPAR Functions in Macrophage Biology

Friday, April 15 | 9:20AM - 9:40AM
Coffee Break
Room: Macdonald Foyer


Friday, April 15 | 11:15AM - 1:00PM
Poster Setup
Room: Macdonald DEF


Friday, April 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Macdonald DEF


Friday, April 15 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Macdonald Foyer


Friday, April 15 | 5:00PM - 7:00PM
Diabetes
Room: MacDonald BC

Speaker 1 of 4
Willa A. Hsueh, Methodist Hospital Research Institute, USA
Cardiomyocyte Specific Deletion of PPARƒ× - Model of Diabetic Cardiomyopathy ?

Friday, April 15 | 5:00PM - 7:00PM
Diabetes
Room: MacDonald BC

Speaker 2 of 4
V. Krishna K. Chatterjee, University of Cambridge, UK
Molecular Spectrum of Mutations in Human PPARg Associated with Severe Insulin Resistance

Friday, April 15 | 5:00PM - 7:00PM
Diabetes
Room: MacDonald BC

Speaker 3 of 4
Yu-Hua Tseng, Joslin Diabetes Center/Harvard Medical School, USA
Transcriptional Control of Adipogenesis - Novel Insights from Gene Expression Profile

Friday, April 15 | 5:00PM - 7:00PM
Diabetes
Room: MacDonald BC

Speaker 4 of 4
Barbara C. Hansen, University of South Florida, Tampa, USA
Short Talk: Insulin Sensitizing By A PPARalpha Specific Agonist K-111 Closely Relates To Reduced Subcutaneous Adipose Tissue Lipoprotein Lipase Activity In Obese Monkeys

Friday, April 15 | 5:00PM - 7:30PM
Bioactive Lipids and Human Disease
This session is from Lipids
Room: MacDonald A

Speaker 1 of 5
Carlo Patrono, University of Rome, Italy
Aspirin-Resistant Eicosanoid Formation in Atherothrombosis


Friday, April 15 | 5:00PM - 7:30PM
Bioactive Lipids and Human Disease
This session is from Lipids
Room: MacDonald A

Speaker 2 of 5
Jilly F. Evans, PharmAkea Therapeutics, USA
Leukotrienes and Cardiovascular Diseases


Friday, April 15 | 5:00PM - 7:30PM
Bioactive Lipids and Human Disease
This session is from Lipids
Room: MacDonald A

Speaker 3 of 5
Joseph L. Witztum, University of California, San Diego, USA
Innate Immune Receptors Recognize Conformational Epitopes of Lipids


Friday, April 15 | 5:00PM - 7:30PM
Bioactive Lipids and Human Disease
This session is from Lipids
Room: MacDonald A

Speaker 4 of 5
* Stanley L. Hazen, Cleveland Clinical Foundation, USA
Photo-Oxidation of Retinal Rod Outer Segment Phospholipids Serves as a Physiological “Eat Me” Signal for CD36-Mediated Phagocytosis by Retinal Pigment Epithelium


Friday, April 15 | 5:00PM - 7:30PM
Bioactive Lipids and Human Disease
This session is from Lipids
Room: MacDonald A

Speaker 5 of 5
Gail E. Grant, Health Canada, Canada
Short Talk: Oxidative Stress Induces the Production of 5-oxo-ETE from Arachidonic Acid in B Cell Lines


Friday, April 15 | 7:00PM - 8:00PM
Social Hour
Room: Macdonald Foyer


Friday, April 15 | 7:30PM - 10:00PM
Poster Session 3
Room: Macdonald DEF


Saturday, April 16 | 7:00AM - 8:00AM
Breakfast
Room: MacDonald DEF


Saturday, April 16 | 8:00AM - 11:00AM
New Frontiers (Joint)
Room: MacDonald ABC

Speaker 1 of 7
* Garret A. FitzGerald, University of Pennsylvania, USA

Saturday, April 16 | 8:00AM - 11:00AM
New Frontiers (Joint)
Room: MacDonald ABC

Speaker 2 of 7
* Ronald M. Evans, HHMI/The Salk Institute, USA

Saturday, April 16 | 8:00AM - 11:00AM
New Frontiers (Joint)
Room: MacDonald ABC

Speaker 3 of 7
Daniel J. Rader, University of Pennsylvania, USA
Molecular Regulation of Reverse Cholesterol Transport

Saturday, April 16 | 8:00AM - 11:00AM
New Frontiers (Joint)
Room: MacDonald ABC

Speaker 4 of 7
David A. Jones, University of Utah, USA
APC Control of Retinoic Acid and Prostaglandin Biosynthetic Enzymes

Saturday, April 16 | 8:00AM - 11:00AM
New Frontiers (Joint)
Room: MacDonald ABC

Speaker 5 of 7
Ueli Schibler, University of Geneva, Switzerland
The Daily Rhythms of Genes Cells and Organs

Saturday, April 16 | 8:00AM - 11:00AM
New Frontiers (Joint)
Room: MacDonald ABC

Speaker 6 of 7
Bing Ren, Ludwig Institute for Cancer Research, USA
Mapping the Genome's Second Code

Saturday, April 16 | 8:00AM - 11:00AM
New Frontiers (Joint)
Room: MacDonald ABC

Speaker 7 of 7
Qianfei Jeffrey Wang, Lawrence Berkeley National Laboratory, USA
Short Talk: Primate Sequence Comparisons Identify Lineage Specific Regulatory Elements in Human Lipid Genes

Saturday, April 16 | 9:20AM - 9:40AM
Coffee Break
Room: Macdonald Foyer


Saturday, April 16 | 4:30PM - 5:00PM
Coffee & Snacks Available
Room: Macdonald Foyer


Saturday, April 16 | 5:00PM - 7:00PM
Cardiovascular Disease
Room: MacDonald BC

Speaker 1 of 4
* Helen H. Hobbs, University of Texas Southwestern Medical Center, USA
Metabolic Effects of Non-Cholesterol Sterols

Saturday, April 16 | 5:00PM - 7:00PM
Cardiovascular Disease
Room: MacDonald BC

Speaker 2 of 4
Daniel P. Kelly, University of Pennsylvania, USA
PPAR Signaling in the Normal and Diseased Heart

Saturday, April 16 | 5:00PM - 7:00PM
Cardiovascular Disease
Room: MacDonald BC

Speaker 3 of 4
Bart Staels, Institut Pasteur de Lille, Université Lille, France
PPARa, the Metabolic Syndrome and Atherosclerosis.

Saturday, April 16 | 5:00PM - 7:00PM
Cardiovascular Disease
Room: MacDonald BC

Speaker 4 of 4
Jorge Plutzky, Brigham and Women's Hospital, USA
Short Talk: Endogenous Mechanisms for Regulating PPAR Responses in Vascular Biology and Inflammation

Saturday, April 16 | 5:00PM - 7:00PM
Bioactive Lipid Signals
This session is from Lipids
Room: MacDonald A

Speaker 1 of 4
* Robert C. Murphy, University of Colorado Denver, USA


Saturday, April 16 | 5:00PM - 7:00PM
Bioactive Lipid Signals
This session is from Lipids
Room: MacDonald A

Speaker 2 of 4
Yusuf A. Hannun, Stony Brook Cancer Center, USA
Neutral sphingomyelinases in eukaryotic cell regulation


Saturday, April 16 | 5:00PM - 7:00PM
Bioactive Lipid Signals
This session is from Lipids
Room: MacDonald A

Speaker 3 of 4
Frank A. Fitzpatrick, University of Utah, USA
Inflammation and Lipid Mediators: Novel Mechanisms of Cancer Risk


Saturday, April 16 | 5:00PM - 7:00PM
Bioactive Lipid Signals
This session is from Lipids
Room: MacDonald A

Speaker 4 of 4
Pallavi R. Devchand, Harvard Medical School, USA
Short Talk: Defining Impact of Lipid Signaling Circuits in the Colon After Resolution of Colitis


Saturday, April 16 | 7:00PM - 8:00PM
Social Hour
Room: Frontenac ABC


Saturday, April 16 | 8:00PM - 11:00PM
Entertainment
Room: Frontenac ABC


Saturday, April 16 | 8:00PM - 11:00PM
Cash Bar
Room: Frontenac ABC


Sunday, April 17 | 10:26AM - 10:26AM
Departure


*Session Chair.