Web Desc
Lymphocyte Activation and Signaling
Organizer(s): Susan K. Pierce, Gary A. Koretzky, Pamela L. Schwartzberg and Jason G. Cyster
Date: January 06 - 11, 2006
Location: Sheraton Steamboat Resort, Steamboat Springs, CO, USA
Supported by The Director's Fund
Summary of Meeting:
The cells of the immune system are armed with a dizzying array of signaling receptors requiring them to integrate an enormous amount of information about their environment to mount the appropriate biologic response. Over the last several years much has been learned about the biochemical nature of the signaling cascades initiated by interactions of individual receptors with their ligands. This progress presents an exciting new challenge, namely, to understand how multiple signals are integrated in the context of the entire cell to bring about the ultimate cellular response. We propose to bring together distinguished scientists working at the cutting edge of immune cell signaling to describe their new findings and to address how these issues relate to human disease. This meeting will provide a view of 1) how the initial encounter of immune cell signaling receptors with their ligands ultimately leads to the biological response, be it activation, differentiation, movement, or cell death and 2) how this knowledge is being translated to important clinical problems in autoimmunity, immunodeficiency, vaccines, tumor immunity, transplantation and infectious diseases.
Scholarship Deadline: September 13 2005
Discounted Abstract Deadline: September 13 2005
Abstract Deadline: October 5 2005
Discounted Registration Deadline: November 7 2005
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.Educational donation provided by AmgenNovartis Institutes for BioMedical Research
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genentech, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13 AI068311-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, January 06 | 3:00PM - 7:30PM
Registration
Room: Foyer


Friday, January 06 | 6:30PM - 7:30PM
Refreshments
Room: Foyer


Friday, January 06 | 7:30PM - 8:30PM
Keynote Address
Room: Storm Peak / Mt. Werner

Speaker 1 of 1
Lewis L. Lanier, University of California, San Francisco, USA
Immunoreceptor Tyrosine-Based 'Ambiguos' Motif (ITAM) Signaling

Saturday, January 07 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles / Sevens


Saturday, January 07 | 8:00AM - 11:00AM
Early Events in Immune Cell Signaling
Room: Storm Peak / Mt. Werner

Speaker 1 of 5
Lawrence E. Samelson, National Institutes of Health, USA
Signaling via the T Cell Antigen Receptor

Saturday, January 07 | 8:00AM - 11:00AM
Early Events in Immune Cell Signaling
Room: Storm Peak / Mt. Werner

Speaker 2 of 5
* Andrey S. Shaw, Genentech, Inc., USA
Complex Roles of the Immunological Synapse

Saturday, January 07 | 8:00AM - 11:00AM
Early Events in Immune Cell Signaling
Room: Storm Peak / Mt. Werner

Speaker 3 of 5
Gary A. Koretzky, University of Pennsylvania School of Medicine, USA
Role of SLP-76 in Immune Cell Development and Function

Saturday, January 07 | 8:00AM - 11:00AM
Early Events in Immune Cell Signaling
Room: Storm Peak / Mt. Werner

Speaker 4 of 5
Susan K. Pierce, NIAID, National Institutes of Health, USA
Viewing the Initiation of B Cell Receptor Signaling in Living Cells by FRET

Saturday, January 07 | 8:00AM - 11:00AM
Early Events in Immune Cell Signaling
Room: Storm Peak / Mt. Werner

Speaker 5 of 5
Tomohiro Kurosaki, Osaka University, Japan
Short Talk: RasGRP3, A Key Molecule for Ras Activation in B Lymphocytes

Saturday, January 07 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Saturday, January 07 | 11:00AM - 1:00PM
Poster Setup
Room: Sunshine Peak


Saturday, January 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunshine Peak


Saturday, January 07 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Saturday, January 07 | 5:00PM - 7:00PM
Regulation of Signaling in the Adaptive and Innate Immune Sy
stems

Room: Storm Peak / Mt. Werner

Speaker 1 of 5
* Arthur Weiss, University of California, San Francisco, USA
Regulating Antigen Receptor Signal Transduction

Saturday, January 07 | 5:00PM - 7:00PM
Regulation of Signaling in the Adaptive and Innate Immune Sy
stems

Room: Storm Peak / Mt. Werner

Speaker 2 of 5
Pamela L. Schwartzberg, NIAID, NHGRI, National Institutes of Health, USA
Development of a Novel CD8+ T Cell Image in Mice Deficient in the Tec Kinases Itk and RIK

Saturday, January 07 | 5:00PM - 7:00PM
Regulation of Signaling in the Adaptive and Innate Immune Sy
stems

Room: Storm Peak / Mt. Werner

Speaker 3 of 5
Silvia Bolland, NIAID, National Institutes of Health, USA
Short Talk: Autoimmune Acceleration by Genomic Duplication of TLR Genes

Saturday, January 07 | 5:00PM - 7:00PM
Regulation of Signaling in the Adaptive and Innate Immune Sy
stems

Room: Storm Peak / Mt. Werner

Speaker 4 of 5
Takashi Saito, RIKEN Center for Allergy and Immunology, Japan
Short Talk: Newly Generated TCR Microclusters Initiate and Sustain T Cell Activation

Saturday, January 07 | 5:00PM - 7:00PM
Regulation of Signaling in the Adaptive and Innate Immune Sy
stems

Room: Storm Peak / Mt. Werner

Speaker 5 of 5
Christopher E. Rudd, University of Montreal, Canada
Short Talk: SKAP-55 and T Cell Imaging

Saturday, January 07 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Foyer


Saturday, January 07 | 7:30PM - 10:00PM
Poster Session 1
Room: Sunshine Peak


Sunday, January 08 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles / Sevens


Sunday, January 08 | 8:00AM - 11:00AM
Signaling and Cell Activation Imaged in Living Cells and in
Vivo

Room: Storm Peak / Mt. Werner

Speaker 1 of 5
Akihiro Kusumi, Kyoto University, Japan
Ligand-Induced Stabilized Raft as a Signaling Platform for GPI-Anchored Receptors: A Single-Molecule Tracking Study

Sunday, January 08 | 8:00AM - 11:00AM
Signaling and Cell Activation Imaged in Living Cells and in
Vivo

Room: Storm Peak / Mt. Werner

Speaker 2 of 5
Ellen A. Robey, University of California, Berkeley, USA
Imaging the Dynamic Behavior of T Cells and Thymocytes in Tissues

Sunday, January 08 | 8:00AM - 11:00AM
Signaling and Cell Activation Imaged in Living Cells and in
Vivo

Room: Storm Peak / Mt. Werner

Speaker 3 of 5
* Michael L. Dustin, University of Oxford, UK
Imaging Immunity Near to Far- T Cell Activation from Molecules to Mice

Sunday, January 08 | 8:00AM - 11:00AM
Signaling and Cell Activation Imaged in Living Cells and in
Vivo

Room: Storm Peak / Mt. Werner

Speaker 4 of 5
Nicholas R. J. Gascoigne, National University of Singapore and Scripps Research, Singapore
Short Talk: Imaging Molecular Interactions during T Cell Recognition Using FRET Microscopy: Endogenous Peptides, Apls and the TCR-CD8 Interaction

Sunday, January 08 | 8:00AM - 11:00AM
Signaling and Cell Activation Imaged in Living Cells and in
Vivo

Room: Storm Peak / Mt. Werner

Speaker 5 of 5
Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
A New Role for Ca++ Signaling In Regulating Lymphocyte Growth and Survivial

Sunday, January 08 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Sunday, January 08 | 11:00AM - 1:00PM
Poster Setup
Room: Sunshine Peak


Sunday, January 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunshine Peak


Sunday, January 08 | 2:30PM - 4:30PM
Workshop 1: Regulation of Signaling in the Adaptive System
Room: Storm Peak / Mt. Werner

Speaker 1 of 9
* Pamela L. Schwartzberg, NIAID, NHGRI, National Institutes of Health, USA

Sunday, January 08 | 2:30PM - 4:30PM
Workshop 1: Regulation of Signaling in the Adaptive System
Room: Storm Peak / Mt. Werner

Speaker 2 of 9
Andrew D. Wells, University of Pennsylvania, USA
Foxp3 Binds to the IL-2 And IFNgamma Genes in T Cells and Promotes Histone Deacetylation in a TCR-Dependent Manner

Sunday, January 08 | 2:30PM - 4:30PM
Workshop 1: Regulation of Signaling in the Adaptive System
Room: Storm Peak / Mt. Werner

Speaker 3 of 9
Jian Zhang, University Of Chicago, USA
Cbl-B Negatively Regulates Antigen Receptor-Induced NF-KappaB Activation via Controlling the Assembly of PKC-Theta/CARMA1/Bcl10/MALT1/IKK Signaling Complex in T Cells

Sunday, January 08 | 2:30PM - 4:30PM
Workshop 1: Regulation of Signaling in the Adaptive System
Room: Storm Peak / Mt. Werner

Speaker 4 of 9
Jennifer L. Cannons, National Institutes of Health, USA
T Cell-mediated Regulation of Humoral Immunity by SAP

Sunday, January 08 | 2:30PM - 4:30PM
Workshop 1: Regulation of Signaling in the Adaptive System
Room: Storm Peak / Mt. Werner

Speaker 5 of 9
Haewon Sohn, NIAID, National Institutes of Health, USA
Short Talk: FRET Imaging in Living Cells Reveals the Dynamics of Membrane Changes in Initiation of B Cell Receptor Signaling

Sunday, January 08 | 2:30PM - 4:30PM
Workshop 1: Regulation of Signaling in the Adaptive System
Room: Storm Peak / Mt. Werner

Speaker 6 of 9
Donna L. Farber, Columbia University Medical Center, USA
Divergent Generation of Heterogeneous Memory CD4 T cells

Sunday, January 08 | 2:30PM - 4:30PM
Workshop 1: Regulation of Signaling in the Adaptive System
Room: Storm Peak / Mt. Werner

Speaker 7 of 9
Iannis Aifantis, New York University School of Medicine, USA
Short Talk: The Hedgehog Signaling Network Controls Lymphoid Progenitor Homeostasis and Differentiation in the Thymus

Sunday, January 08 | 2:30PM - 4:30PM
Workshop 1: Regulation of Signaling in the Adaptive System
Room: Storm Peak / Mt. Werner

Speaker 8 of 9
Amanda L. Prince, University of Massachusetts, USA
Alternative Differentiation of CD4 T Cells in the Absence of Jak3

Sunday, January 08 | 2:30PM - 4:30PM
Workshop 1: Regulation of Signaling in the Adaptive System
Room: Storm Peak / Mt. Werner

Speaker 9 of 9
Jim Miller, University of Rochester, USA
T Cell Costimulation through the Immunological Synapse

Sunday, January 08 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Sunday, January 08 | 5:00PM - 7:00PM
Integration of Signaling in the Adaptive and Innate Immune S
ystems

Room: Storm Peak / Mt. Werner

Speaker 1 of 4
* Juan Rivera, USA
Integrating Signaling In Mast Cells: IgEIAg-Mediated Response

Sunday, January 08 | 5:00PM - 7:00PM
Integration of Signaling in the Adaptive and Innate Immune S
ystems

Room: Storm Peak / Mt. Werner

Speaker 2 of 4
Mark R. Philips, New York University Cancer Institute, USA
Compartment Specific Ras Signaling in T Cells

Sunday, January 08 | 5:00PM - 7:00PM
Integration of Signaling in the Adaptive and Innate Immune S
ystems

Room: Storm Peak / Mt. Werner

Speaker 3 of 4
Sarah Russell, Swinburne University of Technology, Australia
Short Talk: T Cell Shape and Function is Orchestrated by a Network of T Polarity Proteins.

Sunday, January 08 | 5:00PM - 7:00PM
Integration of Signaling in the Adaptive and Innate Immune S
ystems

Room: Storm Peak / Mt. Werner

Speaker 4 of 4
Randy Q. Cron, University of Pennsylvania, USA
Short Talk: Inhibition of NFAT2 Expression by FOXP3

Sunday, January 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Foyer


Sunday, January 08 | 7:30PM - 10:00PM
Poster Session 2
Room: Sunshine Peak


Monday, January 09 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles / Sevens


Monday, January 09 | 8:00AM - 11:00AM
Late Events in Immune Cell Signaling: Fate Decisions
Room: Storm Peak / Mt. Werner

Speaker 1 of 5
Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
A Genome-Wide RNAi Screen in Drosophila Identifies Novel Regulators of the Ca2+ / Calcineurin/ NFAT Signaling Pathway

Monday, January 09 | 8:00AM - 11:00AM
Late Events in Immune Cell Signaling: Fate Decisions
Room: Storm Peak / Mt. Werner

Speaker 2 of 5
* Steven L. Reiner, Columbia University, USA
Programming of Effector and Memory T Cell Fate

Monday, January 09 | 8:00AM - 11:00AM
Late Events in Immune Cell Signaling: Fate Decisions
Room: Storm Peak / Mt. Werner

Speaker 3 of 5
Rafi Ahmed, Emory University School of Medicine, USA
Memory CD8 T Cell Differentiation during Acute versus Chronic Viral Infection

Monday, January 09 | 8:00AM - 11:00AM
Late Events in Immune Cell Signaling: Fate Decisions
Room: Storm Peak / Mt. Werner

Speaker 4 of 5
Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
Signals that Drive Immunological Memory

Monday, January 09 | 8:00AM - 11:00AM
Late Events in Immune Cell Signaling: Fate Decisions
Room: Storm Peak / Mt. Werner

Speaker 5 of 5
Victor L.J. Tybulewicz, Francis Crick Institute, UK
Short Talk: The Role of Rac Gtpases and their Exchange Factors in Lymphocyte Activation and Development

Monday, January 09 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Monday, January 09 | 11:00AM - 1:00PM
Poster Setup
Room: Sunshine Peak


Monday, January 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunshine Peak


Monday, January 09 | 2:30PM - 4:30PM
Workshop 2: Regulation of Signaling in the Adaptive and Inna
te Immune Systems
Room: Storm Peak / Mt. Werner

Speaker 1 of 9
* Lewis L. Lanier, University of California, San Francisco, USA

Monday, January 09 | 2:30PM - 4:30PM
Workshop 2: Regulation of Signaling in the Adaptive and Inna
te Immune Systems
Room: Storm Peak / Mt. Werner

Speaker 2 of 9
Peter C.L. Beverley, University of Oxford, UK
CD45 is Required for Type I IFN Production and Efficient Viral Antigen Presentation by Dendritic Cells

Monday, January 09 | 2:30PM - 4:30PM
Workshop 2: Regulation of Signaling in the Adaptive and Inna
te Immune Systems
Room: Storm Peak / Mt. Werner

Speaker 3 of 9
Nathalie Bonnefoy-Berard, INSERM U851, France
TLR2 Engagement on CD8 T Cells Lowers the Threshold for Optimal antigen-Induced T Cell Activation

Monday, January 09 | 2:30PM - 4:30PM
Workshop 2: Regulation of Signaling in the Adaptive and Inna
te Immune Systems
Room: Storm Peak / Mt. Werner

Speaker 4 of 9
Xingxing Zang, Memorial Sloan-Kettering Cancer Center, USA
B7x: A New B7-1/B7-2 Family Member that Regulates Immune Functions

Monday, January 09 | 2:30PM - 4:30PM
Workshop 2: Regulation of Signaling in the Adaptive and Inna
te Immune Systems
Room: Storm Peak / Mt. Werner

Speaker 5 of 9
Jeffrey C. Rathmell, Vanderbilt University, USA
Akt1 Preferentially Mediates Cytokine Regulated Glucose Uptake in Resting and Activated Lymphocytes

Monday, January 09 | 2:30PM - 4:30PM
Workshop 2: Regulation of Signaling in the Adaptive and Inna
te Immune Systems
Room: Storm Peak / Mt. Werner

Speaker 6 of 9
Lawrence R. Shiow, University of California, San Francisco, USA
CD69 Acts Downstream of IFNalpha/beta to Inhibit S1P1 and Lymphocyte Egress

Monday, January 09 | 2:30PM - 4:30PM
Workshop 2: Regulation of Signaling in the Adaptive and Inna
te Immune Systems
Room: Storm Peak / Mt. Werner

Speaker 7 of 9
Ilaria Tassi, Alector, USA
The Cytotoxicity Receptor CRACC (CS-1) Recruits EAT-2 and Activates the PI-3K and PLCgamma Signaling Pathways in Human NK Cells

Monday, January 09 | 2:30PM - 4:30PM
Workshop 2: Regulation of Signaling in the Adaptive and Inna
te Immune Systems
Room: Storm Peak / Mt. Werner

Speaker 8 of 9
Philip D. King, University of Michigan Medical School, USA
Short Talk: Essential Role of the T Cell-Specific Adapter Protein in the Activation of LCK in Peripheral T Cells

Monday, January 09 | 2:30PM - 4:30PM
Workshop 2: Regulation of Signaling in the Adaptive and Inna
te Immune Systems
Room: Storm Peak / Mt. Werner

Speaker 9 of 9
Shane Crotty, La Jolla Institute for Immunology, USA
SAP Regulation of Follicular Helper CD4 T Cell Development is Independent of SLAM and Fyn Kinase

Monday, January 09 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Monday, January 09 | 5:00PM - 7:00PM
Cell Death and Homeostasis
Room: Storm Peak / Mt. Werner

Speaker 1 of 4
Philippa C. Marrack, HHMI/National Jewish Health, USA
T Cell Life and Death is Controlled by Members of the Bcl-2 Family

Monday, January 09 | 5:00PM - 7:00PM
Cell Death and Homeostasis
Room: Storm Peak / Mt. Werner

Speaker 2 of 4
Jason G. Cyster, HHMI/University of California, San Francisco, USA
Lymphocyte Position Control by Activation Signals

Monday, January 09 | 5:00PM - 7:00PM
Cell Death and Homeostasis
Room: Storm Peak / Mt. Werner

Speaker 3 of 4
* Michael J. Lenardo, NIAID, National Institutes of Health, USA
Apoptotic Signaling and Disease

Monday, January 09 | 5:00PM - 7:00PM
Cell Death and Homeostasis
Room: Storm Peak / Mt. Werner

Speaker 4 of 4
Michael A. Farrar, University of Minnesota, USA
Short Talk: Interleukin-2 Receptor-dependent STAT5 Activation is Required for Regulatory T Cell Development

Monday, January 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Foyer


Monday, January 09 | 7:30PM - 10:00PM
Poster Session 3
Room: Sunshine Peak


Tuesday, January 10 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles / Sevens


Tuesday, January 10 | 8:00AM - 11:00AM
Signaling in Disease Processes
Room: Storm Peak / Mt. Werner

Speaker 1 of 5
André Veillette, Institut de Recherches Cliniques de Montreal, Canada
Signaling by SAP-Related Adaptors

Tuesday, January 10 | 8:00AM - 11:00AM
Signaling in Disease Processes
Room: Storm Peak / Mt. Werner

Speaker 2 of 5
Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA
Determinants of Regulatory T Cell Development

Tuesday, January 10 | 8:00AM - 11:00AM
Signaling in Disease Processes
Room: Storm Peak / Mt. Werner

Speaker 3 of 5
* John J. O'Shea, NIAMS, National Institutes of Health, USA
Cytokine Signaling and Lymphoid Development, Differentiation and Immunoregulation

Tuesday, January 10 | 8:00AM - 11:00AM
Signaling in Disease Processes
Room: Storm Peak / Mt. Werner

Speaker 4 of 5
Flavius Martin, Amgen, Inc., USA
Mechanisms of B Cell Targeted Immunotherapy: Contributions of Microenvironment and Effector Function

Tuesday, January 10 | 8:00AM - 11:00AM
Signaling in Disease Processes
Room: Storm Peak / Mt. Werner

Speaker 5 of 5
Richard M. Siegel, NIAMS, National Institutes of Health, USA
Short Talk: TL1A/DR3 TNF Family Interactions in T cell Costimulation, Death and Differentiation

Tuesday, January 10 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Tuesday, January 10 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, January 10 | 5:00PM - 7:00PM
Modeling Immune Cell Signaling
Room: Storm Peak / Mt. Werner

Speaker 1 of 4
Johannes Huppa, Stanford University, USA
Short Talk: Imaging T Cell Antigen Recognition by Single Molecule Microscopy

Tuesday, January 10 | 5:00PM - 7:00PM
Modeling Immune Cell Signaling
Room: Storm Peak / Mt. Werner

Speaker 2 of 4
* Ronald N. Germain, NIAID, National Institutes of Health, USA
Modeling T Cell Antigen Discrimination: The Key Role of Feedback Control Circuits

Tuesday, January 10 | 5:00PM - 7:00PM
Modeling Immune Cell Signaling
Room: Storm Peak / Mt. Werner

Speaker 3 of 4
Arup K. Chakraborty, Massachusetts Institute of Technology, USA
How T Cells Hunt for Antigen

Tuesday, January 10 | 5:00PM - 7:00PM
Modeling Immune Cell Signaling
Room: Storm Peak / Mt. Werner

Speaker 4 of 4
Aaron R. Dinner, University of Chicago, USA
Short Talk: Computational Model for Signaling in Dual TCR Cells

Tuesday, January 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Foyer


Tuesday, January 10 | 8:00PM - 11:00PM
Entertainment
Room: Sunshine


Tuesday, January 10 | 8:00PM - 11:00PM
Cash Bar
Room: Sunshine


Wednesday, January 11 | 10:26AM - 10:26AM
Departure


*Session Chair.