Web Desc
Genome Sequence Variation and the Inherited Basis of Common Disease and Complex Traits
Organizer(s): David M. Altshuler, Peter Donnelly and Trudy F.C. MacKay
Date: January 08 - 13, 2006
Location: Big Sky Resort, Big Sky, MT, USA
Supported by The Director's Fund
For important information on the coronavirus, please click here
Summary of Meeting:
Common human diseases and most other traits vary in a continuous manner, modified by multiple genes and environmental influences. Rapidly expanding information about genome sequence variation is making it possible, for the first time, to conduct well-powered searches for the inherited contributors to common diseases and other complex phenotypes. Success will provide insight into the genetic architecture of quantitative characters, the evolutionary history of trait variation, and the etiology of common human diseases. This meeting aims to bring together investigators from population genetics, genomics, quantitative genetics, epidemiology and medical research to examine these problems from a variety of perspectives.
Scholarship Deadline: September 13 2005
Discounted Abstract Deadline: October 4 2005
Abstract Deadline: October 4 2005
Discounted Registration Deadline: November 7 2005
We gratefully acknowledge additional support for this conference from:
Integrated DNA TechnologiesJDRF
We gratefully acknowledge the generous grant for this conference provided by:

National Human Genome Research Institute (NHGRI)
Grant No. 1R13 HG003937-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 08 | 3:00PM - 7:30PM
Registration
Room: Lower Atrium


Sunday, January 08 | 6:30PM - 7:30PM
Refreshments
Room: Lower Atrium


Sunday, January 08 | 7:30PM - 9:30PM
Overview Session: Progress and Prospects
Room: Gallatin/Madison

Speaker 1 of 3
* Peter Donnelly, University of Oxford and Genomics plc, UK

Sunday, January 08 | 7:30PM - 9:30PM
Overview Session: Progress and Prospects
Room: Gallatin/Madison

Speaker 2 of 3
Trudy F.C. Mackay, North Carolina State University, USA
Genetic Analysis of Complex Traits in Drosophila

Sunday, January 08 | 7:30PM - 9:30PM
Overview Session: Progress and Prospects
Room: Gallatin/Madison

Speaker 3 of 3
David M. Altshuler, Vertex Pharmaceuticals Incorporated, USA
Genetic Analysis of Complex Traits in Humans

Monday, January 09 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson/Lake/Canyon


Monday, January 09 | 8:00AM - 11:00AM
Genome Sequence Variation
Room: Gallatin/Madison

Speaker 1 of 5
* Charles H. Langley, University of California, Davis, USA
Genomic Patterns of Polymorphism and Divergence: Models and Observations

Monday, January 09 | 8:00AM - 11:00AM
Genome Sequence Variation
Room: Gallatin/Madison

Speaker 2 of 5
Kelly A. Frazer, University of California San Diego School of Medicine, USA
Human DNA Variation and Complex Traits

Monday, January 09 | 8:00AM - 11:00AM
Genome Sequence Variation
Room: Gallatin/Madison

Speaker 3 of 5
Deborah A. Nickerson, University of Washington, USA
SNPs in Candidate Genes

Monday, January 09 | 8:00AM - 11:00AM
Genome Sequence Variation
Room: Gallatin/Madison

Speaker 4 of 5
Charles Lee, Brigham and Women's Hospital, USA
Structural Variations in the Human Genome

Monday, January 09 | 8:00AM - 11:00AM
Genome Sequence Variation
Room: Gallatin/Madison

Speaker 5 of 5
Penelope E. Bonnen, Rockefeller University, USA
Short Talk: Evaluating Potential for Whole Genome Studies in Kosrae - an Isolated Population in Micronesia

Monday, January 09 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Monday, January 09 | 11:00AM - 1:00PM
Poster Setup
Room: Jefferson


Monday, January 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Jefferson


Monday, January 09 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Monday, January 09 | 5:00PM - 7:00PM
Determinants of Variation: Recombination, Demography, Select
ion

Room: Gallatin/Madison

Speaker 1 of 4
* Peter Donnelly, University of Oxford and Genomics plc, UK
Recombination in the Human Genome

Monday, January 09 | 5:00PM - 7:00PM
Determinants of Variation: Recombination, Demography, Select
ion

Room: Gallatin/Madison

Speaker 2 of 4
Molly Przeworski, Columbia University, USA
The Signature of Directional Selection on Standing Genetic Variation

Monday, January 09 | 5:00PM - 7:00PM
Determinants of Variation: Recombination, Demography, Select
ion

Room: Gallatin/Madison

Speaker 3 of 4
Jonathan K. Pritchard, Stanford University, USA
A High-Resolution Survey of Deletion Polymorphism in the Human Genome.

Monday, January 09 | 5:00PM - 7:00PM
Determinants of Variation: Recombination, Demography, Select
ion

Room: Gallatin/Madison

Speaker 4 of 4
Steven A. McCarroll, Harvard Medical School, USA
Short Talk: A Genome-Wide Map of Common Human Deletion Polymorphisms

Monday, January 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Jefferson/Lower Atrium


Monday, January 09 | 7:30PM - 10:00PM
Poster Session 1
Room: Jefferson


Tuesday, January 10 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson/Lake/Canyon


Tuesday, January 10 | 8:00AM - 11:00AM
Computational Approaches Linking Genotype and Phenotype
Room: Gallatin/Madison

Speaker 1 of 5
* Heather Cordell, University of Cambridge, UK
Multiple Imputation Methods for Genetic Association Analysis of Complex Traits

Tuesday, January 10 | 8:00AM - 11:00AM
Computational Approaches Linking Genotype and Phenotype
Room: Gallatin/Madison

Speaker 2 of 5
Zhao-Bang Zeng, North Carolina State University, USA
QTL Analysis, eQTL Analysis and Genetic Architecture of Complex Traits

Tuesday, January 10 | 8:00AM - 11:00AM
Computational Approaches Linking Genotype and Phenotype
Room: Gallatin/Madison

Speaker 3 of 5
Andrew G. Clark, Cornell University, USA
Population Genetic Methods for Genotype-Phenotype Association

Tuesday, January 10 | 8:00AM - 11:00AM
Computational Approaches Linking Genotype and Phenotype
Room: Gallatin/Madison

Speaker 4 of 5
Jonathan L. Marchini, University of Oxford, UK
Short Talk: A Novel Bayesian Approach to Localising Disease Genes

Tuesday, January 10 | 8:00AM - 11:00AM
Computational Approaches Linking Genotype and Phenotype
Room: Gallatin/Madison

Speaker 5 of 5
Dan Arking, Johns Hopkins School of Medicine, USA
Short Talk

Tuesday, January 10 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Tuesday, January 10 | 11:00AM - 1:00PM
Poster Setup
Room: Jefferson


Tuesday, January 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Jefferson


Tuesday, January 10 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Tuesday, January 10 | 5:00PM - 7:00PM
Short Talks
Room: Gallatin/Madison

Speaker 1 of 8
* Trudy F.C. Mackay, North Carolina State University, USA

Tuesday, January 10 | 5:00PM - 7:00PM
Short Talks
Room: Gallatin/Madison

Speaker 2 of 8
Jared Drake, Children's Hospital Boston, USA
Conserved Non-Coding Sequences are Selectively Constrained and not Mutation Cold Spots

Tuesday, January 10 | 5:00PM - 7:00PM
Short Talks
Room: Gallatin/Madison

Speaker 3 of 8
Benjamin F. Voight, University of Chicago, USA
A Genome-Wide Scan for Targets of Recent and On-Going Directional Selection in Humans

Tuesday, January 10 | 5:00PM - 7:00PM
Short Talks
Room: Gallatin/Madison

Speaker 4 of 8
Melanie Bahlo, Walter and Eliza Hall Institute of Medical Research, Australia
Linkage Disequilibrium Mapping Malaria Susceptibility Loci in Papua New Guinea

Tuesday, January 10 | 5:00PM - 7:00PM
Short Talks
Room: Gallatin/Madison

Speaker 5 of 8
Julian T. Forton, University of Oxford, UK
Exploiting Allele-Specific Transcript Quantification and the HAPMAP Resource to Localise Long Range Cis-Regulatory Polymorphism

Tuesday, January 10 | 5:00PM - 7:00PM
Short Talks
Room: Gallatin/Madison

Speaker 6 of 8
Keyan Zhao, Cornell University, USA
Genome-Wide Association Mapping in a Structured Population of A. thaliana

Tuesday, January 10 | 5:00PM - 7:00PM
Short Talks
Room: Gallatin/Madison

Speaker 7 of 8
Minerva M. Carrasquillo, Mayo Clinic, USA
A Set of Putative Functional IDE Variants Shows Simple, Replicable Association with Alzheimer’s Disease and has an Estimated Population Attributable Risk of 46%

Tuesday, January 10 | 5:00PM - 7:00PM
Short Talks
Room: Gallatin/Madison

Speaker 8 of 8
Dana C. Crawford, Case Western Reserve University, USA
Genetic Variation is Associated with C-Reactive Protein Levels in a Survey of 7,000 Americans

Tuesday, January 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Jefferson/Lower Atrium


Tuesday, January 10 | 7:30PM - 10:00PM
Poster Session 2
Room: Jefferson


Wednesday, January 11 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson/Lake/Canyon


Wednesday, January 11 | 8:00AM - 11:00AM
Architecture of Complex Trait Variation
Room: Gallatin/Madison

Speaker 1 of 6
* Catherine (Katie) L. Peichel, Fred Hutchinson Cancer Research Center, USA
Genetic Analysis of Behavioral Differences Between Sympatric Stickleback Species

Wednesday, January 11 | 8:00AM - 11:00AM
Architecture of Complex Trait Variation
Room: Gallatin/Madison

Speaker 2 of 6
Rachel B. Brem, University of California, Berkeley, USA
Transcript Phenotypes and Sequence Variation in Yeast Genomes

Wednesday, January 11 | 8:00AM - 11:00AM
Architecture of Complex Trait Variation
Room: Gallatin/Madison

Speaker 3 of 6
Wolfgang Stephan, University of Munich, Germany
The Role of Selection in Shaping Polymorphism

Wednesday, January 11 | 8:00AM - 11:00AM
Architecture of Complex Trait Variation
Room: Gallatin/Madison

Speaker 4 of 6
Justin Fay, Washington University, USA
Evolution of Transcriptional Regulation

Wednesday, January 11 | 8:00AM - 11:00AM
Architecture of Complex Trait Variation
Room: Gallatin/Madison

Speaker 5 of 6
Justin P. Gerke, Washington University, USA
Short Talk: Analysis of Natural Variation in Yeast Sporulation Efficiency

Wednesday, January 11 | 8:00AM - 11:00AM
Architecture of Complex Trait Variation
Room: Gallatin/Madison

Speaker 6 of 6
Chao-Qiang Lai, JM-USDA-HNRCA at Tufts University, USA
Short Talk: Microarray-based Mapping of QTLs Affecting Lifespan
in Drosophila melanogaster


Wednesday, January 11 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Wednesday, January 11 | 11:00AM - 1:00PM
Poster Setup
Room: Jefferson


Wednesday, January 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Jefferson


Wednesday, January 11 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Wednesday, January 11 | 5:00PM - 7:00PM
Modeling Human Complex Disease Traits in Other Species
Room: Gallatin/Madison

Speaker 1 of 4
* Gary A. Churchill, The Jackson Laboratory, USA
Co-Adaptated Alleles and the Evolution of Complex Traits

Wednesday, January 11 | 5:00PM - 7:00PM
Modeling Human Complex Disease Traits in Other Species
Room: Gallatin/Madison

Speaker 2 of 4
Joseph H. Nadeau, Maine Medical Center Research Institute, USA

Wednesday, January 11 | 5:00PM - 7:00PM
Modeling Human Complex Disease Traits in Other Species
Room: Gallatin/Madison

Speaker 3 of 4
J. Lawrence Marsh, University of California, Irvine, USA
Identification of Genetic Factors that Affect Huntington’s Disease Pathology in Drosophila

Wednesday, January 11 | 5:00PM - 7:00PM
Modeling Human Complex Disease Traits in Other Species
Room: Gallatin/Madison

Speaker 4 of 4
Justin O. Borevitz, University of Chicago, USA
Short Talk: Genome Wide Association Mapping in Arabidopsis thaliana

Wednesday, January 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Jefferson/Lower Atrium


Wednesday, January 11 | 7:30PM - 10:00PM
Poster Session 3
Room: Jefferson


Thursday, January 12 | 7:00AM - 8:00AM
Breakfast
Room: Jefferson/Lake/Canyon


Thursday, January 12 | 8:00AM - 11:00AM
Genetic Basis of Human Disease
Room: Gallatin/Madison

Speaker 1 of 5
Richard P. Lifton, HHMI/Yale University School of Medicine, USA
Genetic Basis of Blood Pressure Variation

Thursday, January 12 | 8:00AM - 11:00AM
Genetic Basis of Human Disease
Room: Gallatin/Madison

Speaker 2 of 5
Jonathan C. Cohen, University of Texas Southwestern Medical Center, USA
Genetic Determinants of Plasma Lipoprotein Levels

Thursday, January 12 | 8:00AM - 11:00AM
Genetic Basis of Human Disease
Room: Gallatin/Madison

Speaker 3 of 5
Leena P. Peltonen, University of Helsinki and National Public Health Inst, Finland
From Families to Populations: Example of Finland

Thursday, January 12 | 8:00AM - 11:00AM
Genetic Basis of Human Disease
Room: Gallatin/Madison

Speaker 4 of 5
Augie Kong, deCODE genetics, Iceland
Complex Diseases and Association Studies

Thursday, January 12 | 8:00AM - 11:00AM
Genetic Basis of Human Disease
Room: Gallatin/Madison

Speaker 5 of 5
Jenny C. Lee, University of California, Los Angeles, USA
Short Talk: Human Sequence Variation Data Facilitates the Fine Mapping of a Low High-Density Lipoprotein Cholesterol Region on Chromosome 16q23-24

Thursday, January 12 | 9:20AM - 9:40AM
Coffee Break
Room: Lower Atrium


Thursday, January 12 | 4:30PM - 5:00PM
Coffee Available
Room: Lower Atrium


Thursday, January 12 | 5:00PM - 7:00PM
Genetics, Medicine and Society
Room: Gallatin/Madison

Speaker 1 of 4
* David M. Altshuler, Vertex Pharmaceuticals Incorporated, USA

Thursday, January 12 | 5:00PM - 7:00PM
Genetics, Medicine and Society
Room: Gallatin/Madison

Speaker 2 of 4
Joel N. Hirschhorn, Children's Hospital, Boston, USA
New Insights into the Genetics of Obesity and Cardiovascular Traits

Thursday, January 12 | 5:00PM - 7:00PM
Genetics, Medicine and Society
Room: Gallatin/Madison

Speaker 3 of 4
Kang Zhang, University of Utah, USA
Short Talk: Genetic Study of Diabetic Complications, Age-Related Macular Degeneration, and Glaucoma Using the Utah Population Database

Thursday, January 12 | 5:00PM - 7:00PM
Genetics, Medicine and Society
Room: Gallatin/Madison

Speaker 4 of 4
Nicole M. Walley, Duke University, USA
Short Talk

Thursday, January 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Jefferson/Lower Atrium


Thursday, January 12 | 8:00PM - 11:00PM
Entertainment
Room: Jefferson


Thursday, January 12 | 8:00PM - 11:00PM
Cash Bar
Room: Jefferson


Friday, January 13 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.