Web Desc
Eicosanoids in Inflammation and Chronic Diseases
Organizer(s): K. Frank Austen, Roy J. Soberman and Jilly F. Evans
Date: January 10 - 15, 2006
Location: Yarrow Resort Hotel, Park City, UT, USA
Supported by The Director's Fund
Summary of Meeting:
The consideration of eicosanoids in chronic inflammatory disease will provide a molecular and structural background that will integrate basic, translational, clinical and therapeutic findings. To focus on eicosanoids as elements in chronic inflammation, it appears instructive to examine three clinical entities in which inflammation is superimposed on pathobiology modulated by genetic and environmental susceptibilities. These entities -- atherosclerosis, rheumatoid arthritis, and bronchial asthma with remodeling -- involve different organ systems, yet share the cellular events of chronicity and evidence for involvement of eicosanoids. Various eicosanoids have been implicated in chronic inflammatory diseases by identification of eicosanoid producing cells within clinical lesions, positional cloning of disease associated candidate genes within the eicosanoid generating pathway, and targeted mutations within the eicosanoid generating pathway that interrupt surrogate animal models of a clinical entity. The identification of two or more receptors for a particular eicosanoid at the cellular membrane of bone marrow-derived inflammatory cells has expanded the role of eicosanoids to all aspects of the innate and adaptive immune host inflammatory responses. The generation of eicosanoids by leukocytes is regulated during cell differentiation and after maturation by local peripheral tissue-derived growth factors and cytokines. Finally, particular eicosanoids can have opposing cellular functions uncovered through the time course of their appearance or the profile of receptor expression on the target cell.
Scholarship Deadline: September 14 2005
Discounted Abstract Deadline: September 14 2005
Abstract Deadline: October 6 2005
Discounted Registration Deadline: November 10 2005
We gratefully acknowledge additional support for this conference from:
Educational donation provided by AmgenNovartis Institutes for BioMedical Research
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Educational grant from Millennium Pharmaceuticals, Inc., The Takeda Oncology Company
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Tuesday, January 10 | 3:00PM - 7:30PM
Registration
Room: Lobby


Tuesday, January 10 | 6:30PM - 7:30PM
Refreshments
Room: Summit C


Tuesday, January 10 | 7:30PM - 8:30PM
Keynote Address
Room: Summit A-B

Speaker 1 of 1
Garret A. FitzGerald, University of Pennsylvania, USA
Prostaglandins and Cardiovascular Biology

Wednesday, January 11 | 7:00AM - 8:00AM
Breakfast
Room: Ivers/Hearst/Kearns & Mountain View


Wednesday, January 11 | 8:00AM - 11:00AM
The Biology and Biochemistry of Phospholipases
Room: Summit A-B

Speaker 1 of 5
* Christina C. Leslie, National Jewish Health, USA
Regulation of Cytosolic Phospholipase A2 Activation and COX2 Expression in Macrophages by the Beta-Glucan Receptor

Wednesday, January 11 | 8:00AM - 11:00AM
The Biology and Biochemistry of Phospholipases
Room: Summit A-B

Speaker 2 of 5
Michael H. Gelb, University of Washington, USA
The Role of Phospholipases A2 in Eicosanoid Generation and Airway Inflammation

Wednesday, January 11 | 8:00AM - 11:00AM
The Biology and Biochemistry of Phospholipases
Room: Summit A-B

Speaker 3 of 5
Jonathan P. Arm, Bill & Melinda Gates Foundation, USA
How Group V Phospholipase A2 Amplifies Inflammation

Wednesday, January 11 | 8:00AM - 11:00AM
The Biology and Biochemistry of Phospholipases
Room: Summit A-B

Speaker 4 of 5
Dieter Steinhilber, University of Frankfurt, Germany
Pathways Involved in Cellular 5-Lipoxygenase Activation

Wednesday, January 11 | 8:00AM - 11:00AM
The Biology and Biochemistry of Phospholipases
Room: Summit A-B

Speaker 5 of 5
Peter F. Weller, Beth Israel Deaconess Medical Center, USA
Short Talk: 5-Lipoxygenase Localization to Cytosolic Lipid Bodies in Rat Basophil Leukemia Cells

Wednesday, January 11 | 9:20AM - 9:40AM
Coffee Break
Room: Summit Hallway


Wednesday, January 11 | 11:00AM - 1:00PM
Poster Setup
Room: Summit C


Wednesday, January 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Summit C


Wednesday, January 11 | 4:30PM - 5:00PM
Coffee Available
Room: Summit Hallway


Wednesday, January 11 | 5:00PM - 7:00PM
Structural Biology of Proteins in the Eicosanoid Pathways
Room: Summit A-B

Speaker 1 of 3
* William L. Smith, University of Michigan, USA
Omega-3 and Omega-6 Essential Fatty Acids, COX-1 and COX-2, and TP and IP Receptors

Wednesday, January 11 | 5:00PM - 7:00PM
Structural Biology of Proteins in the Eicosanoid Pathways
Room: Summit A-B

Speaker 2 of 3
Ingeborg Schmidt-Krey, Georgia Institute of Technology, USA
Structure Determination of LTC4 Synthase by Electron Crystallography

Wednesday, January 11 | 5:00PM - 7:00PM
Structural Biology of Proteins in the Eicosanoid Pathways
Room: Summit A-B

Speaker 3 of 3
Daniel J. Müller, ETH Zurich, Switzerland
Observing Folding Kinetics, Ligand Binding and Activation of a Single Antiporter

Wednesday, January 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Summit C


Wednesday, January 11 | 7:30PM - 10:00PM
Poster Session 1
Room: Summit C


Thursday, January 12 | 7:00AM - 8:00AM
Breakfast
Room: Ivers/Hearst/Kearns & Mountain View


Thursday, January 12 | 8:00AM - 11:00AM
Integrative Biology of Leukotriene Synthesis
Room: Summit A-B

Speaker 1 of 5
* Roy J. Soberman, Harvard Medical School, USA
The Membrane Organization of Leukotriene and Prostaglandin Formation

Thursday, January 12 | 8:00AM - 11:00AM
Integrative Biology of Leukotriene Synthesis
Room: Summit A-B

Speaker 2 of 5
Douglas Kenneth Miller, Miller Associates, LLC, USA
The Structure/Function of FLAP

Thursday, January 12 | 8:00AM - 11:00AM
Integrative Biology of Leukotriene Synthesis
Room: Summit A-B

Speaker 3 of 5
Susan P. C. Cole, Queen's University, Canada
Structure Function Studies of the LTC4 Transporter, MRP1 (ABCC1)

Thursday, January 12 | 8:00AM - 11:00AM
Integrative Biology of Leukotriene Synthesis
Room: Summit A-B

Speaker 4 of 5
Robert C. Murphy, University of Colorado Denver, USA
Moving LTA4 Through and Between Cells: Transcellular Biosynthesis

Thursday, January 12 | 8:00AM - 11:00AM
Integrative Biology of Leukotriene Synthesis
Room: Summit A-B

Speaker 5 of 5
Thomas G. Brock, University of Michigan, USA
Short Talk: Protein Kinase A Inhibits 5-Lipoxygenase Activity by Two Mechanisms

Thursday, January 12 | 9:20AM - 9:40AM
Coffee Break
Room: Summit Hallway


Thursday, January 12 | 11:00AM - 1:00PM
Poster Setup
Room: Summit C


Thursday, January 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Summit C


Thursday, January 12 | 2:30PM - 4:30PM
Workshop 1: Eicosinoids in Human Disease, Animal Models, and
Mechanisms of Action
Room: Summit A-B

Speaker 1 of 7
* Shuh Narumiya, Kyoto University, Japan

Thursday, January 12 | 2:30PM - 4:30PM
Workshop 1: Eicosinoids in Human Disease, Animal Models, and
Mechanisms of Action
Room: Summit A-B

Speaker 2 of 7
Hans-Erik Claesson, Biolipox AB, Sweden
Evidence for a Pathophysiological Role of Cysteinyl Leukotrienes in Hodgkin Lymphoma

Thursday, January 12 | 2:30PM - 4:30PM
Workshop 1: Eicosinoids in Human Disease, Animal Models, and
Mechanisms of Action
Room: Summit A-B

Speaker 3 of 7
Nora A. Barrett, Brigham and Women's Hospital, USA
Short Talk: Cysteinyl Leukotriene-Dependent Th2 Pulmonary Inflammation

Thursday, January 12 | 2:30PM - 4:30PM
Workshop 1: Eicosinoids in Human Disease, Animal Models, and
Mechanisms of Action
Room: Summit A-B

Speaker 4 of 7
John-David H. Herlihy, University of Florida, USA
Alterations in Gene Expression in the Eicosanoid Pathway in a Mouse Model of Allergic Asthma in Normal and CFTR Knockout Mice

Thursday, January 12 | 2:30PM - 4:30PM
Workshop 1: Eicosinoids in Human Disease, Animal Models, and
Mechanisms of Action
Room: Summit A-B

Speaker 5 of 7
Irving C. Allen, Virginia Tech, USA
Thromboxane A2 Induces Airway Constriction Through An M3 Muscarinic Acetylcholine Receptor Dependent Mechanism

Thursday, January 12 | 2:30PM - 4:30PM
Workshop 1: Eicosinoids in Human Disease, Animal Models, and
Mechanisms of Action
Room: Summit A-B

Speaker 6 of 7
Charles D. Loftin, University of Kentucky, USA
Genetic or Pharmacological Inactivation of COX-2 Attenuates Abdominal Aortic Aneurysm Formation in Mice

Thursday, January 12 | 2:30PM - 4:30PM
Workshop 1: Eicosinoids in Human Disease, Animal Models, and
Mechanisms of Action
Room: Summit A-B

Speaker 7 of 7
Dore Sylvain, University of Florida, USA
Prostaglandin EP1 Receptor Contributes to Excitotocicity and Focal Ischemic Brain Damage

Thursday, January 12 | 4:30PM - 5:00PM
Coffee Available
Room: Summit Hallway


Thursday, January 12 | 5:00PM - 7:00PM
Eicosanoids and Adaptive Immunity
Room: Summit A-B

Speaker 1 of 4
Gwendalyn J. Randolph, Washington University, USA
The Regulation of Langerhans Cell Migration by LTC4

Thursday, January 12 | 5:00PM - 7:00PM
Eicosanoids and Adaptive Immunity
Room: Summit A-B

Speaker 2 of 4
Martin R. Hodge, Pfizer, USA
Regulation of Allergic Inflammation by CRTH2

Thursday, January 12 | 5:00PM - 7:00PM
Eicosanoids and Adaptive Immunity
Room: Summit A-B

Speaker 3 of 4
* Bart N. Lambrecht, VIB, Ghent University, Belgium
Control of Dendritic Cell Function by Prostaglandin D2

Thursday, January 12 | 5:00PM - 7:00PM
Eicosanoids and Adaptive Immunity
Room: Summit A-B

Speaker 4 of 4
Richard M. Breyer, Vanderbilt University Medical Center, USA
Short Talk: The Role of PGD2 In Experimental Autoimmune Encephalomyelitis

Thursday, January 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Summit C


Thursday, January 12 | 7:30PM - 10:00PM
Poster Session 2
Room: Summit C


Friday, January 13 | 7:00AM - 8:00AM
Breakfast
Room: Ivers/Hearst/Kearns & Mountain View


Friday, January 13 | 8:00AM - 11:00AM
Eicosanoids and Cardiovascular Disease
Room: Summit A-B

Speaker 1 of 5
* Linda K. Curtiss, The Scripps Research Institute, USA
Atherosclerosis is a Chronic Inflammatory Disease

Friday, January 13 | 8:00AM - 11:00AM
Eicosanoids and Cardiovascular Disease
Room: Summit A-B

Speaker 2 of 5
Colin D. Funk, Queen's University, Canada
5-Lipoxygenase in Vascular Disease and a New Knock-in Model (COX-1>COX-2) to Study Prostaglandin Function

Friday, January 13 | 8:00AM - 11:00AM
Eicosanoids and Cardiovascular Disease
Room: Summit A-B

Speaker 3 of 5
Andreas J. R. Habenicht, Institute for Prophylaxis of Cardiovascular Diseases, Germany
LTD4-Induced Endothelial Cell Genes Indicate Roles of 5-Lipoxygenase in Vascular Inflammation

Friday, January 13 | 8:00AM - 11:00AM
Eicosanoids and Cardiovascular Disease
Room: Summit A-B

Speaker 4 of 5
Margarete Mehrabian, University of California, Los Angeles, USA
5-Lipoxygenase: Pleiotropic Effects on Atherosclerosis, Obesity and Insulin Resistance

Friday, January 13 | 8:00AM - 11:00AM
Eicosanoids and Cardiovascular Disease
Room: Summit A-B

Speaker 5 of 5
Kári Stefánsson, deCode Genetics, Iceland
The Role of the Leukotriene Pathway in the Risk of Myocardial Infarction

Friday, January 13 | 9:20AM - 9:40AM
Coffee Break
Room: Summit Hallway


Friday, January 13 | 4:30PM - 5:00PM
Coffee Available
Room: Summit Hallway


Friday, January 13 | 5:00PM - 7:00PM
Eicosanoids in Arthritis: Human Disease and Animal Models
Room: Summit A-B

Speaker 1 of 5
* K. Frank Austen, Harvard Medical School, USA

Friday, January 13 | 5:00PM - 7:00PM
Eicosanoids in Arthritis: Human Disease and Animal Models
Room: Summit A-B

Speaker 2 of 5
Leslie J. Crofford, University of Kentucky, USA
Prostaglandins in Rheumatoid Arthritis: Can Safe Drugs be Developed?

Friday, January 13 | 5:00PM - 7:00PM
Eicosanoids in Arthritis: Human Disease and Animal Models
Room: Summit A-B

Speaker 3 of 5
David M. Lee, Janssen Pharmaceutical Companies of Johnson & Johnson, USA
Dissecting the 5-LO Pathway in Models of Arthritis

Friday, January 13 | 5:00PM - 7:00PM
Eicosanoids in Arthritis: Human Disease and Animal Models
Room: Summit A-B

Speaker 4 of 5
Ichiro Kudo, Showa University, Japan
Characterization of Mice Lacking Mircrosomal and Cytosolic Prostaglandin E Synthases

Friday, January 13 | 5:00PM - 7:00PM
Eicosanoids in Arthritis: Human Disease and Animal Models
Room: Summit A-B

Speaker 5 of 5
Eri Segi-Nishida, USA
Short Talk: Prostacyclin Signaling Mediates Arthritic Inflammation by Promoting Synovial Cell Activation in Mouse Collagen-Induced Arthritis

Friday, January 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Summit C


Friday, January 13 | 8:00PM - 10:15PM
Workshop 2: Eicosanoids in Human Disease and Relevant Animal
Models
Room: Summit A-B

Speaker 1 of 8
* Jilly F. Evans, PharmAkea Therapeutics, USA
Technologies for Identifying and Designing Future Inhibitors of Enzymes and Receptors

Friday, January 13 | 8:00PM - 10:15PM
Workshop 2: Eicosanoids in Human Disease and Relevant Animal
Models
Room: Summit A-B

Speaker 2 of 8
* Takao Shimizu, University of Tokyo, Japan

Friday, January 13 | 8:00PM - 10:15PM
Workshop 2: Eicosanoids in Human Disease and Relevant Animal
Models
Room: Summit A-B

Speaker 3 of 8
Masataka Majima, Kitasato University School of Medicine, Japan
Stromal Prostaglandin Receptor Signaling Relevant to Tumor-Associated Angiogenesis: Role of Recruitment of Prostaglandin Receptor-Expressing Bone Marrow Cells

Friday, January 13 | 8:00PM - 10:15PM
Workshop 2: Eicosanoids in Human Disease and Relevant Animal
Models
Room: Summit A-B

Speaker 4 of 8
Yan Cheng, University of Pennsylvania, USA
Beyond Inhibition of COX-2: Differential Effects of PG/H and mPGE Synthase Disruption on Prostacyclin Biosynthesis and Cardiovascular Function in vivo

Friday, January 13 | 8:00PM - 10:15PM
Workshop 2: Eicosanoids in Human Disease and Relevant Animal
Models
Room: Summit A-B

Speaker 5 of 8
Christianne Bandeira-Melo, Universidade Federal do Rio de Janeiro, Brazil
PGD2 Controls LTC4 Synthesis by Eosinophils during Allergic Inflammation: Synergistic Role of Endogenous Eotaxin

Friday, January 13 | 8:00PM - 10:15PM
Workshop 2: Eicosanoids in Human Disease and Relevant Animal
Models
Room: Summit A-B

Speaker 6 of 8
Pallavi R. Devchand, Harvard Medical School, USA
Chemical Probing in Rats to Understand Impact of Eicosonoids in Human Colitis-Induced Cancers

Friday, January 13 | 8:00PM - 10:15PM
Workshop 2: Eicosanoids in Human Disease and Relevant Animal
Models
Room: Summit A-B

Speaker 7 of 8
Annalisa Del Prete, University of Bari, Italy
Leukotriene B4 Receptors: Multiple Roles for LTB4 in Dendritic Cell Functions

Friday, January 13 | 8:00PM - 10:15PM
Workshop 2: Eicosanoids in Human Disease and Relevant Animal
Models
Room: Summit A-B

Speaker 8 of 8
Naonori Uozumi, Cincinnati Children's Hospital Medical Center, USA
Disease Model Studies on cPLA2alpha-deficient Mice

Saturday, January 14 | 7:00AM - 8:00AM
Breakfast
Room: Ivers/Hearst/Kearns & Mountain View


Saturday, January 14 | 8:00AM - 11:00AM
Eicosanoids, Asthma, and Airway Inflammation
Room: Summit A-B

Speaker 1 of 6
* Peter F. Weller, Beth Israel Deaconess Medical Center, USA

Saturday, January 14 | 8:00AM - 11:00AM
Eicosanoids, Asthma, and Airway Inflammation
Room: Summit A-B

Speaker 2 of 6
Larry Borish, University of Virginia Medical Center, USA
Cysteinyl Leukotriene Over-Production and Over-Responsiveness in Aspirin-Exacerbated Respiratory Disease

Saturday, January 14 | 8:00AM - 11:00AM
Eicosanoids, Asthma, and Airway Inflammation
Room: Summit A-B

Speaker 3 of 6
Marc Peters-Golden, University of Michigan, USA
Eicosanoids in Fibrotic Lung Disease: A Tale of Two Lipids

Saturday, January 14 | 8:00AM - 11:00AM
Eicosanoids, Asthma, and Airway Inflammation
Room: Summit A-B

Speaker 4 of 6
Alysia K. Lovgren, University of North Carolina at Chapel Hill, USA
Short Talk: COX-2 Mediated Protection against Pulmonary Fibrosis is Not Dependent on Prostaglandin E2 Production

Saturday, January 14 | 8:00AM - 11:00AM
Eicosanoids, Asthma, and Airway Inflammation
Room: Summit A-B

Speaker 5 of 6
Yoshihide Kanaoka, Harvard Medical School, USA
The Function of Cysteinyl Leukotriene Receptors in Lung Inflammation

Saturday, January 14 | 8:00AM - 11:00AM
Eicosanoids, Asthma, and Airway Inflammation
Room: Summit A-B

Speaker 6 of 6
Joshua A. Boyce, Brigham and Women's Hospital, Harvard Medical School, USA
Cysteinyl Leukotrienes and their Receptors as Autocrine Regulators of Mast Cell Function

Saturday, January 14 | 9:20AM - 9:40AM
Coffee Break
Room: Summit Hallway


Saturday, January 14 | 4:30PM - 5:00PM
Coffee Available
Room: Summit Hallway


Saturday, January 14 | 5:00PM - 7:00PM
Receptors for Leukotrienes and Prostaglandins
Room: Summit A-B

Speaker 1 of 4
* Takao Shimizu, University of Tokyo, Japan
Biochemistry and Biology of Leukotriene B4 receptors

Saturday, January 14 | 5:00PM - 7:00PM
Receptors for Leukotrienes and Prostaglandins
Room: Summit A-B

Speaker 2 of 4
Shuh Narumiya, Kyoto University, Japan
Pro- and Anti-Inflammatory Actions of Prostanoids as Revealed by Receptor KO Mice Studies

Saturday, January 14 | 5:00PM - 7:00PM
Receptors for Leukotrienes and Prostaglandins
Room: Summit A-B

Speaker 3 of 4
* Lawrence J. Marnett, Vanderbilt University School of Medicine, USA
Glyceryl Prostaglandins: Novel Bioactive Lipids Produced from Endocannabinoids

Saturday, January 14 | 5:00PM - 7:00PM
Receptors for Leukotrienes and Prostaglandins
Room: Summit A-B

Speaker 4 of 4
Hajime Yoshisue, Southampton General Hospital, UK
Short Talk: Cysteinyl-Leukotrienes Synergise with Receptor Tyrosine Kinase Growth Factors on Mitogenesis of Human Lung Fibroblasts

Saturday, January 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Summit C


Saturday, January 14 | 8:00PM - 11:00PM
Entertainment
Room: Summit C


Saturday, January 14 | 8:00PM - 11:00PM
Cash Bar
Room: Summit C


Sunday, January 15 | 10:26AM - 10:26AM
Departure


*Session Chair.