Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
Sensing and Signaling of Hypoxia: Interfaces with Biology and Medicine (2014A1)
Advances in Hypoxic Signaling: From Bench to Bedside (2012Q4)
Hypoxia: Molecular Mechanisms of Oxygen Sensing and Response Pathways (2010B1)
Molecular, Cellular, Physiological, and Pathogenic Responses to Hypoxia (2008J6)

Web Desc
Hypoxia and Development, Physiology and Disease Organizer(s): M. Celeste Simon, Randall S. Johnson, Amato Giaccia and Max Gassmann Date: January 16 - 21, 2006 Location: Beaver Run Resort, Breckenridge, CO, USA Supported by The Director's Fund For important information on the coronavirus, please click here Summary of Meeting: Research on hypoxia is currently focusing on (1) how cells sense changes in oxygen availability, (2) how hypoxia-inducible factors regulate normal development and physiology, and (3) how oxygen availability effects diseases such as solid tumors, pulmonary hypertension, and tissue ischemia. Major problems in the field include understanding multiple intracellular changes that occur upon oxygen deprivation. The goal of this meeting is to bring together hypoxia researchers studying yeast, fly, worm, mammals, development, tissue homeostasis, disease, and drug discovery. Scholarship Deadline: September 15 2005 Discounted Abstract Deadline: September 15 2005 Abstract Deadline: October 10 2005 Discounted Registration Deadline: November 16 2005 We gratefully acknowledge additional support for this conference from: Ruskinn Technology Ltd, a division of the Baker Company, Inc. We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements: Genzyme Corporation We gratefully acknowledge the generous grant for this conference provided by: National Cancer Institute (NCI) Grant No. 1 R13 CA117421-01 We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Hypoxia and Development, Physiology and Disease

Organizer(s): M. Celeste Simon, Randall S. Johnson, Amato Giaccia and Max Gassmann

Date: January 16 - 21, 2006
Location: Beaver Run Resort, Breckenridge, CO, USA

Supported by The Director's Fund

For important information on the coronavirus, please click here

Summary of Meeting:

Research on hypoxia is currently focusing on (1) how cells sense changes in oxygen availability, (2) how hypoxia-inducible factors regulate normal development and physiology, and (3) how oxygen availability effects diseases such as solid tumors, pulmonary hypertension, and tissue ischemia. Major problems in the field include understanding multiple intracellular changes that occur upon oxygen deprivation. The goal of this meeting is to bring together hypoxia researchers studying yeast, fly, worm, mammals, development, tissue homeostasis, disease, and drug discovery.

Scholarship Deadline: September 15 2005

Discounted Abstract Deadline: September 15 2005

Abstract Deadline: October 10 2005

Discounted Registration Deadline: November 16 2005

We gratefully acknowledge additional support for this conference from:

Ruskinn Technology Ltd, a division of the Baker Company, Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genzyme Corporation

We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1 R13 CA117421-01

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Monday, January 16 \| 3:00PM - 7:30PM Registration Room: Foyer
Monday, January 16 \| 6:30PM - 7:30PM Refreshments Room: Foyer
Monday, January 16 \| 7:30PM - 9:30PM Keynote Session Room: Peaks 1-5 Speaker 1 of 3 * M. Celeste Simon, University of Pennsylvania, USA Welcoming Remarks
Monday, January 16 \| 7:30PM - 9:30PM Keynote Session Room: Peaks 1-5 Speaker 2 of 3 Napoleone Ferrara, University of California, San Diego, USA VEGF, Hypoxia and Tumor Angiogenesis
Monday, January 16 \| 7:30PM - 9:30PM Keynote Session Room: Peaks 1-5 Speaker 3 of 3 Steven L. McKnight, University of Texas Southwestern Medical Center, USA Schizophrenia, Stem Cells and Sprouty Signaling
Tuesday, January 17 \| 7:00AM - 8:00AM Breakfast Room: Peaks 6-12
Tuesday, January 17 \| 8:00AM - 11:20AM Hypoxia and Model Organisms Room: Peaks 1-5 Speaker 1 of 6 Richard K. Bruick, University of Texas Southwestern Medical Center, USA Studies on the Structure, Function, Regulation and Therapeutic Targeting of HIF
Tuesday, January 17 \| 8:00AM - 11:20AM Hypoxia and Model Organisms Room: Peaks 1-5 Speaker 2 of 6 Pablo Wappner, Fundacion Instituto Leloir, Argentina Role of the Drosophila HIF-a Homologue, Sima, in Cell Size Determination and Growth Control
Tuesday, January 17 \| 8:00AM - 11:20AM Hypoxia and Model Organisms Room: Peaks 1-5 Speaker 3 of 6 * Peter J. Ratcliffe, University of Oxford, UK HIF Hydroxylases and Oxygen Signaling
Tuesday, January 17 \| 8:00AM - 11:20AM Hypoxia and Model Organisms Room: Peaks 1-5 Speaker 4 of 6 Peter F. Carmeliet, University of Leuven, VIB, Belgium PHDs in Mice and Zebrafish
Tuesday, January 17 \| 8:00AM - 11:20AM Hypoxia and Model Organisms Room: Peaks 1-5 Speaker 5 of 6 Peter J. Espenshade, Johns Hopkins University School of Medicine, USA Short Talk: SREBP Regulates Anaerobic Gene Expression in Fission Yeast
Tuesday, January 17 \| 8:00AM - 11:20AM Hypoxia and Model Organisms Room: Peaks 1-5 Speaker 6 of 6 Eelke Gort, University Medical Center Utrecht, Netherlands Short Talk: A Whole Genome RNAi Screen in C. elegans Allows Identification of Novel Hypoxia Inducible Factor-1 alpha Regulators in Human Cells
Tuesday, January 17 \| 9:20AM - 9:40AM Coffee Break Room: Foyer
Tuesday, January 17 \| 11:00AM - 1:00PM Poster Setup Room: Peaks 14-17
Tuesday, January 17 \| 1:00PM - 10:00PM Poster Viewing Room: Peaks 14-17
Tuesday, January 17 \| 2:00PM - 4:30PM Workshop 1: Therapeutic Treatment of Hypoxia in Disease Speaker 1 of 9 * Giovanni Melillo, Immuno-Oncology at AstraZeneca, USA Novel Small Molecule Inhibitors of HIF-1
Tuesday, January 17 \| 2:00PM - 4:30PM Workshop 1: Therapeutic Treatment of Hypoxia in Disease Speaker 2 of 9 Adam V. Patterson, University of Auckland, New Zealand PR-104: Development of a New Hypoxic Cytotoxin
Tuesday, January 17 \| 2:00PM - 4:30PM Workshop 1: Therapeutic Treatment of Hypoxia in Disease Speaker 3 of 9 Erwin G. Van Meir, Emory University School of Medicine, USA Novel Small Molecule Inhibitors of Hypoxia-Inducible Factor-1alpha
Tuesday, January 17 \| 2:00PM - 4:30PM Workshop 1: Therapeutic Treatment of Hypoxia in Disease Speaker 4 of 9 Patricia A. Burke, CASI Pharmaceuticals, USA ENMD-1198 Shows Antitumor Activity, Increased Survival, and HIF-1á, NFkappaB and Stat3 Inhibition in vivo
Tuesday, January 17 \| 2:00PM - 4:30PM Workshop 1: Therapeutic Treatment of Hypoxia in Disease Speaker 5 of 9 Todd W. Seeley, FibroGen, Inc., USA FG-2216: Tumor Progression Studies and Correction of Anemia of Cancer in Xenograft Models
Tuesday, January 17 \| 2:00PM - 4:30PM Workshop 1: Therapeutic Treatment of Hypoxia in Disease Speaker 6 of 9 David J. Lomb, University of Rochester, USA HIF Prolyl Hydroxylase Inhibitors Protect Sympathetic Neurons from NGF Deprivation-Induced Death
Tuesday, January 17 \| 2:00PM - 4:30PM Workshop 1: Therapeutic Treatment of Hypoxia in Disease Speaker 7 of 9 Andrea L. Bacon, Cancer Research UK, UK Hypoxia Induced Autophagy and the Role of BNIP3
Tuesday, January 17 \| 2:00PM - 4:30PM Workshop 1: Therapeutic Treatment of Hypoxia in Disease Speaker 8 of 9 Nicholas Denko, Ohio State University, USA HIF1 Reduces Mitochondrial Oxygen Consumption through PDK1 Induction and Protects Tumors from Killing by Hypoxic Cytotoxins
Tuesday, January 17 \| 2:00PM - 4:30PM Workshop 1: Therapeutic Treatment of Hypoxia in Disease Speaker 9 of 9 Frank S. Lee, University of Pennsylvania School of Medicine, USA Familial Erythrocytosis Associated with a Mutation in an Isoform of the HIF prolyl hydroxylase, PHD
Tuesday, January 17 \| 4:30PM - 5:00PM Coffee Available Room: Foyer
Tuesday, January 17 \| 5:00PM - 7:00PM Hypoxic Response in Mammals Room: Peaks 1-5 Speaker 1 of 4 Max Gassmann, University of Zürich, Switzerland Hypoxia and Erythropoietin Gene Expression
Tuesday, January 17 \| 5:00PM - 7:00PM Hypoxic Response in Mammals Room: Peaks 1-5 Speaker 2 of 4 Volker H. Haase, Vanderbilt University, USA Differential HIF Signaling in Tissues with VHL Gene Deletion
Tuesday, January 17 \| 5:00PM - 7:00PM Hypoxic Response in Mammals Room: Peaks 1-5 Speaker 3 of 4 * Randall S. Johnson, University of Cambridge, UK The Physiologic Response to Hypoxia
Tuesday, January 17 \| 5:00PM - 7:00PM Hypoxic Response in Mammals Room: Peaks 1-5 Speaker 4 of 4 Patrick H. Maxwell, Rayne Institute, UK Short Talk: Regulation of E-Cadherin by VHL and HIF
Tuesday, January 17 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Peaks 14-17
Tuesday, January 17 \| 7:30PM - 10:00PM Poster Session 1 Room: Peaks 14-17
Wednesday, January 18 \| 7:00AM - 8:00AM Breakfast Room: Peaks 6-12
Wednesday, January 18 \| 8:00AM - 11:00AM High Altitude Pathophysiology and Pulmonary Responses to Hyp oxia Room: Peaks 1-5 Speaker 1 of 6 * Max Gassmann, University of Zürich, Switzerland
Wednesday, January 18 \| 8:00AM - 11:00AM High Altitude Pathophysiology and Pulmonary Responses to Hyp oxia Room: Peaks 1-5 Speaker 2 of 6 Benjamin D. Levine, Institute for Exercise and Environmental Medicine, USA Cardiovascular Adaptation to Chronic High Altitudes
Wednesday, January 18 \| 8:00AM - 11:00AM High Altitude Pathophysiology and Pulmonary Responses to Hyp oxia Room: Peaks 1-5 Speaker 3 of 6 Damian M. Bailey, University of Glamorgan, UK Free Radicals and Blood-Brain Barrier Function in Acute Mountain Sickness
Wednesday, January 18 \| 8:00AM - 11:00AM High Altitude Pathophysiology and Pulmonary Responses to Hyp oxia Room: Peaks 1-5 Speaker 4 of 6 Sarah Anne Gebb, University of Colorado Health Sciences Center, USA Fetal Oxygen Tension Drives Lung Branching Morphogenesis
Wednesday, January 18 \| 8:00AM - 11:00AM High Altitude Pathophysiology and Pulmonary Responses to Hyp oxia Room: Peaks 1-5 Speaker 5 of 6 Lorna G. Moore, University of Colorado, Denver, USA Hypoxia and the Uteroplacental Circulation
Wednesday, January 18 \| 8:00AM - 11:00AM High Altitude Pathophysiology and Pulmonary Responses to Hyp oxia Room: Peaks 1-5 Speaker 6 of 6 Wanja M. Bernhardt, University Hospital Erlangen-Nuremberg, Germany Short Talk: Preconditional Activation of HIF Ameliorates Ischemic Acute Renal Failure
Wednesday, January 18 \| 9:20AM - 9:40AM Coffee Break Room: Foyer
Wednesday, January 18 \| 11:00AM - 1:00PM Poster Setup Room: Peaks 14-17
Wednesday, January 18 \| 1:00PM - 10:00PM Poster Viewing Room: Peaks 14-17
Wednesday, January 18 \| 4:30PM - 5:00PM Coffee Available Room: Foyer
Wednesday, January 18 \| 5:00PM - 7:00PM Hypoxia and Translation Control Room: Peaks 1-5 Speaker 1 of 4 * M. Celeste Simon, University of Pennsylvania, USA Hypoxia Induced Energy Stress Regulates mRNA Translation and Cell Growth
Wednesday, January 18 \| 5:00PM - 7:00PM Hypoxia and Translation Control Room: Peaks 1-5 Speaker 2 of 4 Bradly G. Wouters, University Health Network, Canada Hypoxic Regulation of Translation Initiation and its Impact on Gene Expression
Wednesday, January 18 \| 5:00PM - 7:00PM Hypoxia and Translation Control Room: Peaks 1-5 Speaker 3 of 4 Stephen Lee, University of Ottawa, Canada Regulation of the HIF/VHL System by Hydrogen Ions
Wednesday, January 18 \| 5:00PM - 7:00PM Hypoxia and Translation Control Room: Peaks 1-5 Speaker 4 of 4 Kevin P. Claffey, University of Connecticut Health Center, USA Short Talk: AMP-dependent Protein Kinase alpha1 and alpha2 are Key Regulators of VEGF Expression and Repression of MAPK Pathways in Cellular Adaptation to Hypoxia
Wednesday, January 18 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Peaks 14-17
Wednesday, January 18 \| 7:30PM - 10:00PM Poster Session 2 Room: Peaks 14-17
Thursday, January 19 \| 7:00AM - 8:00AM Breakfast Room: Peaks 6-12
Thursday, January 19 \| 8:00AM - 11:20AM Physiological and Pathophysiologic Responses to Hypoxia Room: Peaks 1-5 Speaker 1 of 6 * Joachim Fandrey, University Duisburg-Essen, Germany Regulation of HIF-1 by Mediators of Inflammation
Thursday, January 19 \| 8:00AM - 11:20AM Physiological and Pathophysiologic Responses to Hypoxia Room: Peaks 1-5 Speaker 2 of 6 Nanduri R. Prabhakar, University of Chicago, USA O2 Sensing in Intermittent Hypoxia: Role of Reactive Species and HIF-Transcription Factor(s)
Thursday, January 19 \| 8:00AM - 11:20AM Physiological and Pathophysiologic Responses to Hypoxia Room: Peaks 1-5 Speaker 3 of 6 Agnes Görlach, German Heart Center Munich, TU Munich, Germany Short Talk: NFkappaB is Required for HIF-1alpha Transcription in Response to Thrombin and Oxidative Stress
Thursday, January 19 \| 8:00AM - 11:20AM Physiological and Pathophysiologic Responses to Hypoxia Room: Peaks 1-5 Speaker 4 of 6 L. Eric Huang, University of Utah, USA Hypoxia and Genetic Instability
Thursday, January 19 \| 8:00AM - 11:20AM Physiological and Pathophysiologic Responses to Hypoxia Room: Peaks 1-5 Speaker 5 of 6 Eileen P. White, Rutgers University, USA Hypoxia, Apoptosis, and Genome Instability
Thursday, January 19 \| 8:00AM - 11:20AM Physiological and Pathophysiologic Responses to Hypoxia Room: Peaks 1-5 Speaker 6 of 6 Claire E. Lewis, University of Sheffield Medical School, UK Short Talk: Inflammation and tumor progression: the role of the hypoxic macrophage
Thursday, January 19 \| 9:20AM - 9:40AM Coffee Break Room: Foyer
Thursday, January 19 \| 11:00AM - 1:00PM Poster Setup Room: Peaks 14-17
Thursday, January 19 \| 1:00PM - 10:00PM Poster Viewing Room: Peaks 14-17
Thursday, January 19 \| 2:00PM - 4:30PM Workshop 2: Cellular Responses to Hypoxia Speaker 1 of 8 * Masi M. Yamamoto, Tohoku University, Japan Regulation of Erythropoietin Gene Expression
Thursday, January 19 \| 2:00PM - 4:30PM Workshop 2: Cellular Responses to Hypoxia Speaker 2 of 8 Constantinos Koumenis, University of Pennsylvania, USA The Role of the Unfolded Protein Response in Tumor Cell Resistance to Hypoxia/Anoxia
Thursday, January 19 \| 2:00PM - 4:30PM Workshop 2: Cellular Responses to Hypoxia Speaker 3 of 8 Lawrence B. Gardner, New York University School of Medicine, USA Hypoxic Suppression of Id-1 via Activation of the Unfolded Protein Response is Aberrant in Neuroblastoma
Thursday, January 19 \| 2:00PM - 4:30PM Workshop 2: Cellular Responses to Hypoxia Speaker 4 of 8 Vibha Chauhan, Stanford University, USA Zhangfei is a Novel Gene that is Induced by both Hypoxia and ER Stress and Regulates XBP1 Function.
Thursday, January 19 \| 2:00PM - 4:30PM Workshop 2: Cellular Responses to Hypoxia Speaker 5 of 8 Bing-Hua Jiang, Thomas Jefferson University, USA AKT 1 Regulates VEGF and HIF-1alpha Expression through HDM2, TSC1/2, and p70S6K1 Pathways
Thursday, January 19 \| 2:00PM - 4:30PM Workshop 2: Cellular Responses to Hypoxia Speaker 6 of 8 Robert D. Guzy, University of Chicago, USA Disruption of Mitochondrial Complex II Leads to Increased ROS, Normoxic HIF-1alpha Stabilization, and Enhanced Tumor Formation
Thursday, January 19 \| 2:00PM - 4:30PM Workshop 2: Cellular Responses to Hypoxia Speaker 7 of 8 Cormac Taylor, University College Dublin, Ireland Hypoxia Increases the Pool of IKKbeta Leading to NFkappaB Activation: a Possible Role for PHD-1
Thursday, January 19 \| 2:00PM - 4:30PM Workshop 2: Cellular Responses to Hypoxia Speaker 8 of 8 Koh Nakayama, Sanford-Burnham Medical Research Institute, USA Multimerization of PHDs Alters Prolyl-Hydroxylase Activity and Susceptibility to Siah2-Dependent Degradation during Hypoxia
Thursday, January 19 \| 4:30PM - 5:00PM Coffee Available Room: Foyer
Thursday, January 19 \| 5:00PM - 7:00PM Hypoxia, Disease and Drug Discovery Room: Peaks 1-5 Speaker 1 of 4 * Mark W. Dewhirst, Duke University Medical Center, USA Pleiotropic Effects of HIF-1 Blockade on Tumor Radiosensitivity
Thursday, January 19 \| 5:00PM - 7:00PM Hypoxia, Disease and Drug Discovery Room: Peaks 1-5 Speaker 2 of 4 Martin Brown, Stanford University, USA Exploiting Tumor Hypoxia in Cancer Therapy
Thursday, January 19 \| 5:00PM - 7:00PM Hypoxia, Disease and Drug Discovery Room: Peaks 1-5 Speaker 3 of 4 Till Acker, University of Giessen, Germany Short Talk: Regulation of HIF Function in Malignant Brain Tumors by Metabolic Parameters (PO2, pH, glucose, ROS)
Thursday, January 19 \| 5:00PM - 7:00PM Hypoxia, Disease and Drug Discovery Room: Peaks 1-5 Speaker 4 of 4 Ralph A. Kelly, Genzyme Corporation, USA Harnessing the Tissue Response to Hypoxia: Pre-Clinical and Human Experience with a Constitutively Active Hypoxia-Inducible Factor 1 Alpha Transgene in Advanced Vascular Ischemic Disease
Thursday, January 19 \| 7:00PM - 8:00PM Social Hour with Lite Bites Room: Peaks 14-17
Thursday, January 19 \| 7:30PM - 10:00PM Poster Session 3 Room: Peaks 14-17
Friday, January 20 \| 7:00AM - 8:00AM Breakfast Room: Peaks 6-12
Friday, January 20 \| 8:00AM - 11:00AM Signaling of Hypoxia Room: Peaks 1-5 Speaker 1 of 5 * Lorenz Poellinger, Karolinska Institutet, Sweden Structure/Function Analysis of HIF
Friday, January 20 \| 8:00AM - 11:00AM Signaling of Hypoxia Room: Peaks 1-5 Speaker 2 of 5 Margaret Ashcroft, University of Cambridge, UK HDM2 Positively Regulates HIF Expression
Friday, January 20 \| 8:00AM - 11:00AM Signaling of Hypoxia Room: Peaks 1-5 Speaker 3 of 5 Navdeep S. Chandel, Northwestern University, USA Mitochondrial Electron Transport and Oxygen Sensing
Friday, January 20 \| 8:00AM - 11:00AM Signaling of Hypoxia Room: Peaks 1-5 Speaker 4 of 5 Eli Keshet, Hebrew University, Israel Hypoxia and the Hibernating Heart
Friday, January 20 \| 8:00AM - 11:00AM Signaling of Hypoxia Room: Peaks 1-5 Speaker 5 of 5 Maria F. Czyzyk-Krzeska, University of Cincinnati, USA Short Talk: Hydroxylation of Proline 1465 and VHL-Ubiquitylation of Rpb1 is Induced by Oxidative Stress and Controls Oncogenic Process in Renal Cancer Cells in the Absence of HIF
Friday, January 20 \| 9:20AM - 9:40AM Coffee Break Room: Foyer
Friday, January 20 \| 4:30PM - 5:00PM Coffee Available Room: Foyer
Friday, January 20 \| 5:00PM - 7:15PM Hypoxia and Tumorigenesis Room: Peaks 1-5 Speaker 1 of 4 * Amato J. Giaccia, Stanford University, USA Exploiting HIF Gene Expression in Cancer Therapy
Friday, January 20 \| 5:00PM - 7:15PM Hypoxia and Tumorigenesis Room: Peaks 1-5 Speaker 2 of 4 William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA The von Hippel Lindau Cancer Syndrome
Friday, January 20 \| 5:00PM - 7:15PM Hypoxia and Tumorigenesis Room: Peaks 1-5 Speaker 3 of 4 Gabriele A.I. Bergers, University of Leuven, Belgium HIF-1 and Astrocytoma Invasion
Friday, January 20 \| 5:00PM - 7:15PM Hypoxia and Tumorigenesis Room: Peaks 1-5 Speaker 4 of 4 Gregg L. Semenza, Johns Hopkins University School of Medicine, USA HIF-1 Overexpression in Human Cancer: Mechanisms and Consequences
Friday, January 20 \| 7:15PM - 8:15PM Social Hour with Lite Bites Room: Peaks 14-17
Friday, January 20 \| 8:00PM - 11:00PM Entertainment Room: Peaks 14-17
Friday, January 20 \| 8:00PM - 11:00PM Cash Bar Room: Peaks 14-17
Saturday, January 21 \| 10:21AM - 10:21AM Departure *Session Chair †Invited, not yet responded.