Web Desc
Hypoxia and Development, Physiology and Disease
Organizer(s): M. Celeste Simon, Randall S. Johnson, Amato Giaccia and Max Gassmann
Date: January 16 - 21, 2006
Location: Beaver Run Resort, Breckenridge, CO, USA
Supported by The Director's Fund
For important information on the coronavirus, please click here
Summary of Meeting:
Research on hypoxia is currently focusing on (1) how cells sense changes in oxygen availability, (2) how hypoxia-inducible factors regulate normal development and physiology, and (3) how oxygen availability effects diseases such as solid tumors, pulmonary hypertension, and tissue ischemia. Major problems in the field include understanding multiple intracellular changes that occur upon oxygen deprivation. The goal of this meeting is to bring together hypoxia researchers studying yeast, fly, worm, mammals, development, tissue homeostasis, disease, and drug discovery.
Scholarship Deadline: September 15 2005
Discounted Abstract Deadline: September 15 2005
Abstract Deadline: October 10 2005
Discounted Registration Deadline: November 16 2005
We gratefully acknowledge additional support for this conference from:
Novartis Institutes for BioMedical Research
Ruskinn Technology Ltd, a division of the Baker Company, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Genzyme Corporation
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1 R13 CA117421-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, January 16 | 3:00PM - 7:30PM
Registration
Room: Foyer


Monday, January 16 | 6:30PM - 7:30PM
Refreshments
Room: Foyer


Monday, January 16 | 7:30PM - 9:30PM
Keynote Session
Room: Peaks 1-5

Speaker 1 of 3
* M. Celeste Simon, University of Pennsylvania, USA
Welcoming Remarks

Monday, January 16 | 7:30PM - 9:30PM
Keynote Session
Room: Peaks 1-5

Speaker 2 of 3
Napoleone Ferrara, University of California, San Diego, USA
VEGF, Hypoxia and Tumor Angiogenesis

Monday, January 16 | 7:30PM - 9:30PM
Keynote Session
Room: Peaks 1-5

Speaker 3 of 3
Steven L. McKnight, University of Texas Southwestern Medical Center, USA
Schizophrenia, Stem Cells and Sprouty Signaling



Tuesday, January 17 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Tuesday, January 17 | 8:00AM - 11:20AM
Hypoxia and Model Organisms
Room: Peaks 1-5

Speaker 1 of 6
Richard K. Bruick, University of Texas Southwestern Medical Center, USA
Studies on the Structure, Function, Regulation and Therapeutic Targeting of HIF

Tuesday, January 17 | 8:00AM - 11:20AM
Hypoxia and Model Organisms
Room: Peaks 1-5

Speaker 2 of 6
Pablo Wappner, Fundacion Instituto Leloir, Argentina
Role of the Drosophila HIF-a Homologue, Sima, in Cell Size Determination and Growth Control

Tuesday, January 17 | 8:00AM - 11:20AM
Hypoxia and Model Organisms
Room: Peaks 1-5

Speaker 3 of 6
* Peter J. Ratcliffe, University of Oxford, UK
HIF Hydroxylases and Oxygen Signaling

Tuesday, January 17 | 8:00AM - 11:20AM
Hypoxia and Model Organisms
Room: Peaks 1-5

Speaker 4 of 6
Peter F. Carmeliet, University of Leuven, VIB, Belgium
PHDs in Mice and Zebrafish

Tuesday, January 17 | 8:00AM - 11:20AM
Hypoxia and Model Organisms
Room: Peaks 1-5

Speaker 5 of 6
Peter J. Espenshade, Johns Hopkins University School of Medicine, USA
Short Talk: SREBP Regulates Anaerobic Gene Expression in Fission Yeast

Tuesday, January 17 | 8:00AM - 11:20AM
Hypoxia and Model Organisms
Room: Peaks 1-5

Speaker 6 of 6
Eelke Gort, University Medical Center Utrecht, Netherlands
Short Talk: A Whole Genome RNAi Screen in C. elegans Allows Identification of Novel Hypoxia Inducible Factor-1 alpha Regulators in Human Cells

Tuesday, January 17 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Tuesday, January 17 | 11:00AM - 1:00PM
Poster Setup
Room: Peaks 14-17


Tuesday, January 17 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 14-17


Tuesday, January 17 | 2:00PM - 4:30PM
Workshop 1: Therapeutic Treatment of Hypoxia in Disease

Speaker 1 of 9
* Giovanni Melillo, Immuno-Oncology at AstraZeneca, USA
Novel Small Molecule Inhibitors of HIF-1

Tuesday, January 17 | 2:00PM - 4:30PM
Workshop 1: Therapeutic Treatment of Hypoxia in Disease

Speaker 2 of 9
Adam V. Patterson, University of Auckland, New Zealand
PR-104: Development of a New Hypoxic Cytotoxin

Tuesday, January 17 | 2:00PM - 4:30PM
Workshop 1: Therapeutic Treatment of Hypoxia in Disease

Speaker 3 of 9
Erwin G. Van Meir, Emory University School of Medicine, USA
Novel Small Molecule Inhibitors of Hypoxia-Inducible Factor-1alpha

Tuesday, January 17 | 2:00PM - 4:30PM
Workshop 1: Therapeutic Treatment of Hypoxia in Disease

Speaker 4 of 9
Patricia A. Burke, CASI Pharmaceuticals, USA
ENMD-1198 Shows Antitumor Activity, Increased Survival, and HIF-1á, NFkappaB and Stat3 Inhibition in vivo

Tuesday, January 17 | 2:00PM - 4:30PM
Workshop 1: Therapeutic Treatment of Hypoxia in Disease

Speaker 5 of 9
Todd W. Seeley, FibroGen, Inc., USA
FG-2216: Tumor Progression Studies and Correction of Anemia of Cancer in Xenograft Models

Tuesday, January 17 | 2:00PM - 4:30PM
Workshop 1: Therapeutic Treatment of Hypoxia in Disease

Speaker 6 of 9
David J. Lomb, University of Rochester, USA
HIF Prolyl Hydroxylase Inhibitors Protect Sympathetic Neurons from NGF Deprivation-Induced Death

Tuesday, January 17 | 2:00PM - 4:30PM
Workshop 1: Therapeutic Treatment of Hypoxia in Disease

Speaker 7 of 9
Andrea L. Bacon, Cancer Research UK, UK
Hypoxia Induced Autophagy and the Role of BNIP3

Tuesday, January 17 | 2:00PM - 4:30PM
Workshop 1: Therapeutic Treatment of Hypoxia in Disease

Speaker 8 of 9
Nicholas Denko, Ohio State University, USA
HIF1 Reduces Mitochondrial Oxygen Consumption through PDK1 Induction and Protects Tumors from Killing by Hypoxic Cytotoxins

Tuesday, January 17 | 2:00PM - 4:30PM
Workshop 1: Therapeutic Treatment of Hypoxia in Disease

Speaker 9 of 9
Frank S. Lee, University of Pennsylvania School of Medicine, USA
Familial Erythrocytosis Associated with a Mutation in an Isoform of the HIF prolyl hydroxylase, PHD

Tuesday, January 17 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, January 17 | 5:00PM - 7:00PM
Hypoxic Response in Mammals
Room: Peaks 1-5

Speaker 1 of 4
Max Gassmann, University of Zürich, Switzerland
Hypoxia and Erythropoietin Gene Expression

Tuesday, January 17 | 5:00PM - 7:00PM
Hypoxic Response in Mammals
Room: Peaks 1-5

Speaker 2 of 4
Volker H. Haase, Vanderbilt University, USA
Differential HIF Signaling in Tissues with VHL Gene Deletion

Tuesday, January 17 | 5:00PM - 7:00PM
Hypoxic Response in Mammals
Room: Peaks 1-5

Speaker 3 of 4
* Randall S. Johnson, University of Cambridge, UK
The Physiologic Response to Hypoxia

Tuesday, January 17 | 5:00PM - 7:00PM
Hypoxic Response in Mammals
Room: Peaks 1-5

Speaker 4 of 4
Patrick H. Maxwell, Rayne Institute, UK
Short Talk: Regulation of E-Cadherin by VHL and HIF

Tuesday, January 17 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 14-17


Tuesday, January 17 | 7:30PM - 10:00PM
Poster Session 1
Room: Peaks 14-17


Wednesday, January 18 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Wednesday, January 18 | 8:00AM - 11:00AM
High Altitude Pathophysiology and Pulmonary Responses to Hyp
oxia

Room: Peaks 1-5

Speaker 1 of 6
* Max Gassmann, University of Zürich, Switzerland

Wednesday, January 18 | 8:00AM - 11:00AM
High Altitude Pathophysiology and Pulmonary Responses to Hyp
oxia

Room: Peaks 1-5

Speaker 2 of 6
Benjamin D. Levine, Institute for Exercise and Environmental Medicine, USA
Cardiovascular Adaptation to Chronic High Altitudes

Wednesday, January 18 | 8:00AM - 11:00AM
High Altitude Pathophysiology and Pulmonary Responses to Hyp
oxia

Room: Peaks 1-5

Speaker 3 of 6
Damian M. Bailey, University of Glamorgan, UK
Free Radicals and Blood-Brain Barrier Function in Acute Mountain Sickness

Wednesday, January 18 | 8:00AM - 11:00AM
High Altitude Pathophysiology and Pulmonary Responses to Hyp
oxia

Room: Peaks 1-5

Speaker 4 of 6
Sarah Anne Gebb, University of Colorado Health Sciences Center, USA
Fetal Oxygen Tension Drives Lung Branching Morphogenesis

Wednesday, January 18 | 8:00AM - 11:00AM
High Altitude Pathophysiology and Pulmonary Responses to Hyp
oxia

Room: Peaks 1-5

Speaker 5 of 6
Lorna G. Moore, University of Colorado, Denver, USA
Hypoxia and the Uteroplacental Circulation

Wednesday, January 18 | 8:00AM - 11:00AM
High Altitude Pathophysiology and Pulmonary Responses to Hyp
oxia

Room: Peaks 1-5

Speaker 6 of 6
Wanja M. Bernhardt, University Hospital Erlangen-Nuremberg, Germany
Short Talk: Preconditional Activation of HIF Ameliorates Ischemic Acute Renal Failure

Wednesday, January 18 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, January 18 | 11:00AM - 1:00PM
Poster Setup
Room: Peaks 14-17


Wednesday, January 18 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 14-17


Wednesday, January 18 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, January 18 | 5:00PM - 7:00PM
Hypoxia and Translation Control
Room: Peaks 1-5

Speaker 1 of 4
* M. Celeste Simon, University of Pennsylvania, USA
Hypoxia Induced Energy Stress Regulates mRNA Translation and Cell Growth

Wednesday, January 18 | 5:00PM - 7:00PM
Hypoxia and Translation Control
Room: Peaks 1-5

Speaker 2 of 4
Bradly G. Wouters, University Health Network, Canada
Hypoxic Regulation of Translation Initiation and its Impact on Gene Expression

Wednesday, January 18 | 5:00PM - 7:00PM
Hypoxia and Translation Control
Room: Peaks 1-5

Speaker 3 of 4
Stephen Lee, University of Ottawa, Canada
Regulation of the HIF/VHL System by Hydrogen Ions

Wednesday, January 18 | 5:00PM - 7:00PM
Hypoxia and Translation Control
Room: Peaks 1-5

Speaker 4 of 4
Kevin P. Claffey, University of Connecticut Health Center, USA
Short Talk: AMP-dependent Protein Kinase alpha1 and alpha2 are Key Regulators of VEGF Expression and Repression of MAPK Pathways in Cellular Adaptation to Hypoxia

Wednesday, January 18 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 14-17


Wednesday, January 18 | 7:30PM - 10:00PM
Poster Session 2
Room: Peaks 14-17


Thursday, January 19 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Thursday, January 19 | 8:00AM - 11:20AM
Physiological and Pathophysiologic Responses to Hypoxia
Room: Peaks 1-5

Speaker 1 of 6
* Joachim Fandrey, University Duisburg-Essen, Germany
Regulation of HIF-1 by Mediators of Inflammation

Thursday, January 19 | 8:00AM - 11:20AM
Physiological and Pathophysiologic Responses to Hypoxia
Room: Peaks 1-5

Speaker 2 of 6
Nanduri R. Prabhakar, University of Chicago, USA
O2 Sensing in Intermittent Hypoxia: Role of Reactive Species and HIF-Transcription Factor(s)

Thursday, January 19 | 8:00AM - 11:20AM
Physiological and Pathophysiologic Responses to Hypoxia
Room: Peaks 1-5

Speaker 3 of 6
Agnes Görlach, German Heart Center Munich, TU Munich, Germany
Short Talk: NFkappaB is Required for HIF-1alpha Transcription in Response to Thrombin and Oxidative Stress

Thursday, January 19 | 8:00AM - 11:20AM
Physiological and Pathophysiologic Responses to Hypoxia
Room: Peaks 1-5

Speaker 4 of 6
L. Eric Huang, University of Utah, USA
Hypoxia and Genetic Instability

Thursday, January 19 | 8:00AM - 11:20AM
Physiological and Pathophysiologic Responses to Hypoxia
Room: Peaks 1-5

Speaker 5 of 6
Eileen P. White, Rutgers University, USA
Hypoxia, Apoptosis, and Genome Instability

Thursday, January 19 | 8:00AM - 11:20AM
Physiological and Pathophysiologic Responses to Hypoxia
Room: Peaks 1-5

Speaker 6 of 6
Claire E. Lewis, University of Sheffield Medical School, UK
Short Talk: Inflammation and tumor progression: the role of the hypoxic macrophage

Thursday, January 19 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, January 19 | 11:00AM - 1:00PM
Poster Setup
Room: Peaks 14-17


Thursday, January 19 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 14-17


Thursday, January 19 | 2:00PM - 4:30PM
Workshop 2: Cellular Responses to Hypoxia

Speaker 1 of 8
* Masi M. Yamamoto, Tohoku University, Japan
Regulation of Erythropoietin Gene Expression

Thursday, January 19 | 2:00PM - 4:30PM
Workshop 2: Cellular Responses to Hypoxia

Speaker 2 of 8
Constantinos Koumenis, University of Pennsylvania, USA
The Role of the Unfolded Protein Response in Tumor Cell Resistance to Hypoxia/Anoxia

Thursday, January 19 | 2:00PM - 4:30PM
Workshop 2: Cellular Responses to Hypoxia

Speaker 3 of 8
Lawrence B. Gardner, New York University School of Medicine, USA
Hypoxic Suppression of Id-1 via Activation of the Unfolded Protein Response is Aberrant in Neuroblastoma

Thursday, January 19 | 2:00PM - 4:30PM
Workshop 2: Cellular Responses to Hypoxia

Speaker 4 of 8
Vibha Chauhan, Stanford University, USA
Zhangfei is a Novel Gene that is Induced by both Hypoxia and ER Stress and Regulates XBP1 Function.

Thursday, January 19 | 2:00PM - 4:30PM
Workshop 2: Cellular Responses to Hypoxia

Speaker 5 of 8
Bing-Hua Jiang, Thomas Jefferson University, USA
AKT 1 Regulates VEGF and HIF-1alpha Expression through HDM2, TSC1/2, and p70S6K1 Pathways

Thursday, January 19 | 2:00PM - 4:30PM
Workshop 2: Cellular Responses to Hypoxia

Speaker 6 of 8
Robert D. Guzy, University of Chicago, USA
Disruption of Mitochondrial Complex II Leads to Increased ROS, Normoxic HIF-1alpha Stabilization, and Enhanced Tumor Formation

Thursday, January 19 | 2:00PM - 4:30PM
Workshop 2: Cellular Responses to Hypoxia

Speaker 7 of 8
Cormac Taylor, University College Dublin, Ireland
Hypoxia Increases the Pool of IKKbeta Leading to NFkappaB Activation: a Possible Role for PHD-1

Thursday, January 19 | 2:00PM - 4:30PM
Workshop 2: Cellular Responses to Hypoxia

Speaker 8 of 8
Koh Nakayama, Sanford-Burnham Medical Research Institute, USA
Multimerization of PHDs Alters Prolyl-Hydroxylase Activity and Susceptibility to Siah2-Dependent Degradation during Hypoxia

Thursday, January 19 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, January 19 | 5:00PM - 7:00PM
Hypoxia, Disease and Drug Discovery
Room: Peaks 1-5

Speaker 1 of 4
* Mark W. Dewhirst, Duke University Medical Center, USA
Pleiotropic Effects of HIF-1 Blockade on Tumor Radiosensitivity

Thursday, January 19 | 5:00PM - 7:00PM
Hypoxia, Disease and Drug Discovery
Room: Peaks 1-5

Speaker 2 of 4
Martin Brown, Stanford University, USA
Exploiting Tumor Hypoxia in Cancer Therapy

Thursday, January 19 | 5:00PM - 7:00PM
Hypoxia, Disease and Drug Discovery
Room: Peaks 1-5

Speaker 3 of 4
Till Acker, University of Giessen, Germany
Short Talk: Regulation of HIF Function in Malignant Brain Tumors
by Metabolic Parameters (PO2, pH, glucose, ROS)


Thursday, January 19 | 5:00PM - 7:00PM
Hypoxia, Disease and Drug Discovery
Room: Peaks 1-5

Speaker 4 of 4
Ralph A. Kelly, Genzyme Corporation, USA
Harnessing the Tissue Response to Hypoxia: Pre-Clinical and Human Experience with a Constitutively Active Hypoxia-Inducible Factor 1 Alpha Transgene in Advanced Vascular Ischemic Disease

Thursday, January 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 14-17


Thursday, January 19 | 7:30PM - 10:00PM
Poster Session 3
Room: Peaks 14-17


Friday, January 20 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Friday, January 20 | 8:00AM - 11:00AM
Signaling of Hypoxia
Room: Peaks 1-5

Speaker 1 of 5
* Lorenz Poellinger, Karolinska Institutet, Sweden
Structure/Function Analysis of HIF

Friday, January 20 | 8:00AM - 11:00AM
Signaling of Hypoxia
Room: Peaks 1-5

Speaker 2 of 5
Margaret Ashcroft, University of Cambridge, UK
HDM2 Positively Regulates HIF Expression

Friday, January 20 | 8:00AM - 11:00AM
Signaling of Hypoxia
Room: Peaks 1-5

Speaker 3 of 5
Navdeep S. Chandel, Northwestern University, USA
Mitochondrial Electron Transport and Oxygen Sensing

Friday, January 20 | 8:00AM - 11:00AM
Signaling of Hypoxia
Room: Peaks 1-5

Speaker 4 of 5
Eli Keshet, Hebrew University, Israel
Hypoxia and the Hibernating Heart

Friday, January 20 | 8:00AM - 11:00AM
Signaling of Hypoxia
Room: Peaks 1-5

Speaker 5 of 5
Maria F. Czyzyk-Krzeska, University of Cincinnati, USA
Short Talk: Hydroxylation of Proline 1465 and VHL-Ubiquitylation of Rpb1 is Induced by Oxidative Stress and Controls Oncogenic Process in Renal Cancer Cells in the Absence of HIF

Friday, January 20 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Friday, January 20 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Friday, January 20 | 5:00PM - 7:15PM
Hypoxia and Tumorigenesis
Room: Peaks 1-5

Speaker 1 of 4
* Amato J. Giaccia, Stanford University, USA
Exploiting HIF Gene Expression in Cancer Therapy

Friday, January 20 | 5:00PM - 7:15PM
Hypoxia and Tumorigenesis
Room: Peaks 1-5

Speaker 2 of 4
William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA
The von Hippel Lindau Cancer Syndrome

Friday, January 20 | 5:00PM - 7:15PM
Hypoxia and Tumorigenesis
Room: Peaks 1-5

Speaker 3 of 4
Gabriele A.I. Bergers, University of Leuven, Belgium
HIF-1 and Astrocytoma Invasion

Friday, January 20 | 5:00PM - 7:15PM
Hypoxia and Tumorigenesis
Room: Peaks 1-5

Speaker 4 of 4
Gregg L. Semenza, Johns Hopkins University School of Medicine, USA
HIF-1 Overexpression in Human Cancer: Mechanisms and Consequences

Friday, January 20 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Peaks 14-17


Friday, January 20 | 8:00PM - 11:00PM
Entertainment
Room: Peaks 14-17


Friday, January 20 | 8:00PM - 11:00PM
Cash Bar
Room: Peaks 14-17


Saturday, January 21 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.