Web Desc
Epigenetics and Chromatin Remodeling in Development
Organizer(s): Renato Paro and Peter Fraser
Date: January 19 - 24, 2006
Location: Keystone Resort, Keystone, CO, USA
Supported by The Director's Fund
Summary of Meeting:
The stability of gene expression patterns, which define different cellular states, is highly dependent on chromatin structure and function. Regulatory features invoked by, for example, particular histone modifications or nuclear architecture greatly influence the way genetic information is interpreted during developmental processes. Such an epigenetic constitution of the nucleus is heritable, providing the basis for mechanisms like the permanent inactivation of an X chromosome or genomic imprinting in mammalian cells. The recent identification of many components of epigenetic regulation has created enormous excitement in the field, not only because we foresee a better understanding of the basic mechanisms on how developmental decisions are maintained, but also because we might learn how aberrant cases, like cancer cells, change their epigenetic hallmarks. Epigenetic gene control also needs to be considered to better understand and approach more applied topics like nuclear cloning, stem cells and tissue engineering. This meeting will bring together scientists who have identified epigenetic constituents and studied their regulatory contributions at the molecular level, with scientists who study, in more complex organisms, epigenetic programming of cellular fates during normal developmental and in the disease case.
Scholarship Deadline: September 19 2005
Discounted Abstract Deadline: September 19 2005
Abstract Deadline: October 12 2005
Discounted Registration Deadline: November 18 2005
We gratefully acknowledge additional support for this conference from:
Integrated DNA TechnologiesInvitrogen CorporationMarch of Dimes FoundationNovartis Institutes for BioMedical Research
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1 R13 CA117385-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, January 19 | 3:00PM - 7:30PM
Registration
Room: Shavano Peak Foyer


Thursday, January 19 | 6:30PM - 7:30PM
Refreshments
Room: Shavano Peak Foyer


Thursday, January 19 | 7:30PM - 8:30PM
Keynote Address
Room: Shavano Peak

Speaker 1 of 1
Azim Surani, University of Cambridge, UK
Epigenetic Programming of the Genome in the Embryo and Germ Cells

Friday, January 20 | 7:00AM - 8:00AM
Breakfast
Room: Torreys 1-4


Friday, January 20 | 8:00AM - 11:15AM
Chromatin Structure and Function
Room: Shavano Peak

Speaker 1 of 6
C. David Allis, Rockefeller University, USA
Beyond the Double Helix: Reading and Writing the 'Histone Code'

Friday, January 20 | 8:00AM - 11:15AM
Chromatin Structure and Function
Room: Shavano Peak

Speaker 2 of 6
* Peter B. Becker, University of Munich, Germany
Site-Specific Acetylation Defines an Embryonic form of ISWI Associated with Mitotic Chromatin

Friday, January 20 | 8:00AM - 11:15AM
Chromatin Structure and Function
Room: Shavano Peak

Speaker 3 of 6
Zhiguo Zhang, Mayo Clinic, USA
Short Talk: Rtt106p is a Novel Histone Chaperone Involved in Epigenetic Silencing

Friday, January 20 | 8:00AM - 11:15AM
Chromatin Structure and Function
Room: Shavano Peak

Speaker 4 of 6
Stefan Kubicek, Austrian Academy of Sciences, Austria
Epigenetic Control by Histone Methylation

Friday, January 20 | 8:00AM - 11:15AM
Chromatin Structure and Function
Room: Shavano Peak

Speaker 5 of 6
Robert A. Martienssen, Cold Spring Harbor Laboratory, USA
Regulation of Histone Methylation Patterns by RNAi in Plants and Fission Yeast

Friday, January 20 | 8:00AM - 11:15AM
Chromatin Structure and Function
Room: Shavano Peak

Speaker 6 of 6
Kevin V. Morris, Center for Gene Therapy, City of Hope, USA
Short Talk: The Antisense Strand of Small Interfering RNAs Directs Histone Methylation and Transcriptional Gene Silencing in Human Cells

Friday, January 20 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Friday, January 20 | 11:00AM - 1:00PM
Poster Setup
Room: Torreys 1-4


Friday, January 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys 1-4


Friday, January 20 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Friday, January 20 | 5:00PM - 7:00PM
Establishing Epigenetic Marks
Room: Shavano Peak

Speaker 1 of 4
* Steven Henikoff, Fred Hutchinson Cancer Research Center, USA
Epigenetic Patterns Generated by Assembly of Histone Variants into Nucleosomes

Friday, January 20 | 5:00PM - 7:00PM
Establishing Epigenetic Marks
Room: Shavano Peak

Speaker 2 of 4
Caline Karam, Columbia University Medical Center, USA
Short Talk: The Role of JIL-1 Mediated Histone H3 Phosphorylation in Transcriptional Activation

Friday, January 20 | 5:00PM - 7:00PM
Establishing Epigenetic Marks
Room: Shavano Peak

Speaker 3 of 4
En Li, China Novartis Institutes for BioMedical Research, China
Role of DNA Methyltransferases in Mammalian Development

Friday, January 20 | 5:00PM - 7:00PM
Establishing Epigenetic Marks
Room: Shavano Peak

Speaker 4 of 4
Terumi Kohwi-Shigematsu, Lawrence Berkeley National Laboratory, USA
A New Role of Genome Organizer SATB1 in Breast Cancer Mestastasis

Friday, January 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys 1-4


Friday, January 20 | 7:30PM - 10:00PM
Poster Session 1
Room: Torreys 1-4


Saturday, January 21 | 7:00AM - 8:00AM
Breakfast
Room: Torreys 1-4


Saturday, January 21 | 8:00AM - 11:15AM
Chromatin-Controlled Gene Regulation in Development
Room: Shavano Peak

Speaker 1 of 6
* Vicki L. Chandler, Minerva Schools at Keck Graduate Institute, USA
Heritable Chromatin Structures are Established through Trans-Interactions between Tandem Repeats

Saturday, January 21 | 8:00AM - 11:15AM
Chromatin-Controlled Gene Regulation in Development
Room: Shavano Peak

Speaker 2 of 6
Jeannie T. Lee, Massachusetts General Hospital / Harvard Medical School, USA
Cis-Regulatory Chromatin Dynamics at the X-Inactivation Center

Saturday, January 21 | 8:00AM - 11:15AM
Chromatin-Controlled Gene Regulation in Development
Room: Shavano Peak

Speaker 3 of 6
Dominic John Ciavatta, University of North Carolina at Chapel Hill, USA
Short Talk: DNA Insulators Prevent Repression of a Targeted X-linked Transgene but not Its Random or Imprinted X-Inactivation

Saturday, January 21 | 8:00AM - 11:15AM
Chromatin-Controlled Gene Regulation in Development
Room: Shavano Peak

Speaker 4 of 6
Kami Ahmad, Harvard Medical School, USA
Replication-Independent Histone Replacement, Histone Variants and Maintaining Epogenetic States

Saturday, January 21 | 8:00AM - 11:15AM
Chromatin-Controlled Gene Regulation in Development
Room: Shavano Peak

Speaker 5 of 6
Laurie Jackson-Grusby, Harvard Medical School, USA
Reprogramming Epigenetic Imprinting

Saturday, January 21 | 8:00AM - 11:15AM
Chromatin-Controlled Gene Regulation in Development
Room: Shavano Peak

Speaker 6 of 6
Nora I. Engel, Temple University School of Medicine, USA
Insulators, Mathylation and Transcriptional Regulation: Complesities of Imprinting Control

Saturday, January 21 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Saturday, January 21 | 11:00AM - 1:00PM
Poster Setup
Room: Torreys 1-4


Saturday, January 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys 1-4


Saturday, January 21 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Saturday, January 21 | 5:00PM - 7:00PM
Nuclear Positioning
Room: Shavano Peak

Speaker 1 of 4
* Peter Fraser, Florida State University, USA
Nuclear Organization of Transcription

Saturday, January 21 | 5:00PM - 7:00PM
Nuclear Positioning
Room: Shavano Peak

Speaker 2 of 4
Giacomo Cavalli, Institute of Human Genetics, France
Association of Polycomb Group Response Elements in the Nuclear Space

Saturday, January 21 | 5:00PM - 7:00PM
Nuclear Positioning
Room: Shavano Peak

Speaker 3 of 4
Wendy A. Bickmore, University of Edinburgh, UK
Nuclear Re-Organization during Embryonic Development

Saturday, January 21 | 5:00PM - 7:00PM
Nuclear Positioning
Room: Shavano Peak

Speaker 4 of 4
Daryl Gohl, Princeton University, USA
Short Talk: Analyzing Boundary Element Pairing and Competiton

Saturday, January 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys 1-4


Saturday, January 21 | 7:30PM - 10:00PM
Poster Session 2
Room: Torreys 1-4


Sunday, January 22 | 7:00AM - 8:00AM
Breakfast
Room: Torreys 1-4


Sunday, January 22 | 8:00AM - 11:15AM
Mechanisms of Cellular Memory
Room: Shavano Peak

Speaker 1 of 6
Renato Paro, ETH Zurich, Switzerland
Epigenetic Control of Tissue Regeneration in Drosophila

Sunday, January 22 | 8:00AM - 11:15AM
Mechanisms of Cellular Memory
Room: Shavano Peak

Speaker 2 of 6
Maxim Nekrasov, Australian National University, Australia
Short Talk: Characterization of the Drosophila PRC2 HMTase

Sunday, January 22 | 8:00AM - 11:15AM
Mechanisms of Cellular Memory
Room: Shavano Peak

Speaker 3 of 6
Alexander Tarakhovsky, Rockefeller University, USA
Protein Lysine Methylation and Signal Transduction

Sunday, January 22 | 8:00AM - 11:15AM
Mechanisms of Cellular Memory
Room: Shavano Peak

Speaker 4 of 6
Keji Zhao, NHLBI, National Institutes of Health, USA
Short Talk: Identification and Characterization of Human Polycomb Response Elements

Sunday, January 22 | 8:00AM - 11:15AM
Mechanisms of Cellular Memory
Room: Shavano Peak

Speaker 5 of 6
* Ueli Grossniklaus, University of Zürich, Switzerland
Epigenetic Inheritance during Arabidopsis Seed Development

Sunday, January 22 | 8:00AM - 11:15AM
Mechanisms of Cellular Memory
Room: Shavano Peak

Speaker 6 of 6
Peter Verrijzer, Erasmus University Medical Center, Netherlands
PREs are CIS-Regulatory Elements That Mediate Function of PcG and TRXG Proteins

Sunday, January 22 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Sunday, January 22 | 11:00AM - 1:00PM
Poster Setup
Room: Torreys 1-4


Sunday, January 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys 1-4


Sunday, January 22 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Sunday, January 22 | 5:00PM - 7:00PM
Cellular Plasticity and Tissue Reprogramming
Room: Shavano Peak

Speaker 1 of 4
* Eric N. Olson, University of Texas Southwestern Medical Center, USA
Signfalling to the Genome: Lessons from the Heart

Sunday, January 22 | 5:00PM - 7:00PM
Cellular Plasticity and Tissue Reprogramming
Room: Shavano Peak

Speaker 2 of 4
Meinrad Busslinger, Research Institute of Molecular Pathology, Austria
Transcriptional Control of B Cell Identity by Pax5

Sunday, January 22 | 5:00PM - 7:00PM
Cellular Plasticity and Tissue Reprogramming
Room: Shavano Peak

Speaker 3 of 4
Jiang Wu, University of Texas Southwestern Medical Center, USA
Short Talk: An Essential Epigenetic Switch for Progenitor-to-Post-Mitotic Neural Development

Sunday, January 22 | 5:00PM - 7:00PM
Cellular Plasticity and Tissue Reprogramming
Room: Shavano Peak

Speaker 4 of 4
Rudolf Jaenisch, Whitehead Institute for Biomedical Research, USA
Molecular Control of Pluripotency and Self-Renewal

Sunday, January 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys 1-4


Sunday, January 22 | 7:30PM - 10:00PM
Poster Session 3
Room: Torreys 1-4


Monday, January 23 | 7:00AM - 8:00AM
Breakfast
Room: Torreys 1-4


Monday, January 23 | 8:00AM - 11:15AM
Cancer Epigenetics
Room: Shavano Peak

Speaker 1 of 6
* Peter A. Jones, Van Andel Research Institute, USA
DNA Footprinting of CpG Islands at Single Molecule Resolution

Monday, January 23 | 8:00AM - 11:15AM
Cancer Epigenetics
Room: Shavano Peak

Speaker 2 of 6
Tom Latham, Westerb General Hospital, UK
Short Talk: Transgenic Mice Overexpressing DNA Methyltransferase Dnmt3b Develop Abnormal Cpg Island Methylation and Increased Progression of Apc min Intestinal Tumours

Monday, January 23 | 8:00AM - 11:15AM
Cancer Epigenetics
Room: Shavano Peak

Speaker 3 of 6
Stephen B. Baylin, Johns Hopkins University School of Medicine, USA
Epigenetic Control of Cancer or Questions of Epigenetic Networks Gone Wrong

Monday, January 23 | 8:00AM - 11:15AM
Cancer Epigenetics
Room: Shavano Peak

Speaker 4 of 6
Michael J. Boland, University of Nebraska Medical Center, USA
Short Talk: Initial Characterization of an Interaction between C5-DNA Methyltransferase, Dnmt3b, and Thymine DNA Glycosylase

Monday, January 23 | 8:00AM - 11:15AM
Cancer Epigenetics
Room: Shavano Peak

Speaker 5 of 6
Maarten Van Lohuizen, Netherlands Cancer Institute, Netherlands
Polycomb Repressors Controlling Stem Cell Fate: Implications for Cancer and Development

Monday, January 23 | 8:00AM - 11:15AM
Cancer Epigenetics
Room: Shavano Peak

Speaker 6 of 6
Trang Hoang, Université de Montréal, Canada
Integration of Proliferative Signals from EED and BMI1 Proteins

Monday, January 23 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Monday, January 23 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Monday, January 23 | 5:00PM - 7:00PM
Stem Cell Programming
Room: Shavano Peak

Speaker 1 of 4
Allan C. Spradling, HHMI/Carnegie Institute, USA
The Lighten-up/p68 RNA Helicase Regulates Transcriptional Deactivation by Promoting RNA Release from Chromatin

Monday, January 23 | 5:00PM - 7:00PM
Stem Cell Programming
Room: Shavano Peak

Speaker 2 of 4
* Emma Whitelaw, Queensland Institute of Medical Research, Australia
An ENU Screen for Modifiers of Epigenetic Gene Silencing in the Mouse

Monday, January 23 | 5:00PM - 7:00PM
Stem Cell Programming
Room: Shavano Peak

Speaker 3 of 4
David J. Katz, Emory University, USA
Short Talk: Histone H3 Lysine 4 Methylation Guards the Germ Cell Lineage

Monday, January 23 | 5:00PM - 7:00PM
Stem Cell Programming
Room: Shavano Peak

Speaker 4 of 4
Wolf Reik, Babraham Institute, UK
Imprinting and Epigenetic Reprogramming in Mammalian Development


Monday, January 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys 1-4


Monday, January 23 | 8:00PM - 11:00PM
Entertainment
Room: Torreys 1-4


Monday, January 23 | 8:00PM - 11:00PM
Cash Bar
Room: Torreys 1-4


Tuesday, January 24 | 10:26AM - 10:26AM
Departure


*Session Chair.