Web Desc
RNAi and Related Pathways
Organizer(s): Craig C. Mello, Phillip D. Zamore and James C. Carrington
Date: January 26 - 31, 2006
Location: Fairmont Hotel Vancouver, Vancouver, BC, Canada
Sponsored by Abbott Laboratories, Inc. and Alnylam Pharmaceuticals, Inc.
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Summary of Meeting:
RNA silencing phenomena in a variety of plants, animals and fungi share a common underlying mechanism. At the heart of this mechanism lies an ancient double-stranded RNA processing machinery that functions in RNA-based immunity, developmental gene regulation, transcriptional silencing and genomic stability. The aim of this meeting is to explore similarities and differences between these related pathways, to probe the underlying molecular mechanisms and to explore new methods for harnessing these mechanisms for gene discovery and therapeutics applications.
Scholarship Deadline: September 26 2005
Discounted Abstract Deadline: September 26 2005
Abstract Deadline: October 19 2005
Discounted Registration Deadline: November 23 2005
We gratefully acknowledge additional support for this conference from:
Abbott LaboratoriesAlnylam Pharmaceuticals, Inc.Ambion, Inc.Integrated DNA TechnologiesInvitrogen CorporationIsis Pharmaceuticals, Inc.Novartis Institutes for BioMedical Research
We gratefully acknowledge the generous grant for this conference provided by:

National Cancer Institute (NCI)
Grant No. 1 R13 CA117393-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, January 26 | 3:00PM - 7:30PM
Registration
Room: BC Foyer


Thursday, January 26 | 6:30PM - 7:30PM
Refreshments
Room: BC Foyer


Thursday, January 26 | 7:30PM - 9:30PM
Keynote Session
Room: British / Columbia Ballroom

Speaker 1 of 3
* Craig C. Mello, University of Massachusetts Medical School, USA

Thursday, January 26 | 7:30PM - 9:30PM
Keynote Session
Room: British / Columbia Ballroom

Speaker 2 of 3
David C. Baulcombe, University of Cambridge, UK
RNA Silencing in Defense and Development

Thursday, January 26 | 7:30PM - 9:30PM
Keynote Session
Room: British / Columbia Ballroom

Speaker 3 of 3
Victor R. Ambros, University of Massachusetts, USA
MicroRNAs in Flies and Worms

Friday, January 27 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Friday, January 27 | 8:00AM - 11:30AM
RNAi, Development and Systemic Silencing
Room: British / Columbia Ballroom

Speaker 1 of 7
* James C. Carrington, Donald Danforth Plant Science Center, USA

Friday, January 27 | 8:00AM - 11:30AM
RNAi, Development and Systemic Silencing
Room: British / Columbia Ballroom

Speaker 2 of 7
Craig C. Mello, University of Massachusetts Medical School, USA
RNAi and Development in C. elegans

Friday, January 27 | 8:00AM - 11:30AM
RNAi, Development and Systemic Silencing
Room: British / Columbia Ballroom

Speaker 3 of 7
Richard W. Carthew, Northwestern University, USA
Genetics of miRNAs in Drosophila

Friday, January 27 | 8:00AM - 11:30AM
RNAi, Development and Systemic Silencing
Room: British / Columbia Ballroom

Speaker 4 of 7
William Theurkauf, University of Massachusetts Medical Center, USA
Drosophila RNAi Mutations Disrupt Embryonic Axis Specification through Activation of the ATR/Chk2 Tumor Suppressor Pathway

Friday, January 27 | 8:00AM - 11:30AM
RNAi, Development and Systemic Silencing
Room: British / Columbia Ballroom

Speaker 5 of 7
Olivier Voinnet, Swiss Federal Institute of Technology, Zürich, Switzerland
Cell Autonomous and Systemic Mechanisms that Account for Antiviral RNA Silencing in Plants

Friday, January 27 | 8:00AM - 11:30AM
RNAi, Development and Systemic Silencing
Room: British / Columbia Ballroom

Speaker 6 of 7
Craig P. Hunter, Harvard University, USA
Systemic RNAi in C. elegans

Friday, January 27 | 8:00AM - 11:30AM
RNAi, Development and Systemic Silencing
Room: British / Columbia Ballroom

Speaker 7 of 7
Markus Stoffel, ETH Zürich, Switzerland
Short Talk: Silencing of microRNAs in vivo

Friday, January 27 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Friday, January 27 | 11:30AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Friday, January 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Friday, January 27 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Friday, January 27 | 5:00PM - 7:00PM
Regulation of Small RNA Processing and Function
Room: British / Columbia Ballroom

Speaker 1 of 5
* V. Narry Kim, Institute for Basic Science, South Korea

Friday, January 27 | 5:00PM - 7:00PM
Regulation of Small RNA Processing and Function
Room: British / Columbia Ballroom

Speaker 2 of 5
Witold Filipowicz, Friedrich Miescher Institute for Biomedical Research, Switzerland
Reversibility of the miRNA-Mediated Repression / Chromatoid Body: A Giant P-Body of Germ Cells?

Friday, January 27 | 5:00PM - 7:00PM
Regulation of Small RNA Processing and Function
Room: British / Columbia Ballroom

Speaker 3 of 5
Mikiko C. Siomi, University of Tokyo, Japan
Biochemical Characterization of RNAi and miRNA Pathways in Drosophila

Friday, January 27 | 5:00PM - 7:00PM
Regulation of Small RNA Processing and Function
Room: British / Columbia Ballroom

Speaker 4 of 5
Herve Vaucheret, Institut National de la Recherche Agronomique, France
Regulation of Small RNA Pathways in Plants

Friday, January 27 | 5:00PM - 7:00PM
Regulation of Small RNA Processing and Function
Room: British / Columbia Ballroom

Speaker 5 of 5
Amy E. Pasquinelli, University of California, San Diego, USA
Short Talk: Regulation of Gene Expression by miRNAs in C. elegans

Friday, January 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Friday, January 27 | 7:30PM - 10:00PM
Poster Session 1
Room: Pacific Ballroom


Saturday, January 28 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Saturday, January 28 | 8:00AM - 11:30AM
miRNA Mechanisms
Room: British / Columbia Ballroom

Speaker 1 of 7
* David P. Bartel, Massachusetts Institute of Technology and Whitehead Institute, USA

Saturday, January 28 | 8:00AM - 11:30AM
miRNA Mechanisms
Room: British / Columbia Ballroom

Speaker 2 of 7
Joel R. Neilson, Baylor College of Medicine, USA
Short Talk: Dynamic regulation of small RNA expression during T lymphocyte development


Saturday, January 28 | 8:00AM - 11:30AM
miRNA Mechanisms
Room: British / Columbia Ballroom

Speaker 3 of 7
Alan M. Zahler, University of California, Santa Cruz, USA
Short Talk: A Purified lin-4 miRNP Complex Directs Cleavage of its Native mRNA Substrate

Saturday, January 28 | 8:00AM - 11:30AM
miRNA Mechanisms
Room: British / Columbia Ballroom

Speaker 4 of 7
David T. Humphreys, Victor Chang Cardiac Research Institute, Australia
Short Talk: MicroRNAs Control Translation Initiation by Inhibiting Eukaryotic Initiation Factor 4E/cap and poly(A) Tail Function

Saturday, January 28 | 8:00AM - 11:30AM
miRNA Mechanisms
Room: British / Columbia Ballroom

Speaker 5 of 7
* V. Narry Kim, Institute for Basic Science, South Korea
Molecular Basis for pri-miRNA Processing by the Drosha-DGCR8 Complex and A Role for the NMD Factor Upf1 in RNA Silencing

Saturday, January 28 | 8:00AM - 11:30AM
miRNA Mechanisms
Room: British / Columbia Ballroom

Speaker 6 of 7
Xuemei Chen, University of California, Riverside, USA
Methylation of microRNAs and Small Interfering RNAs in Arabidopsis

Saturday, January 28 | 8:00AM - 11:30AM
miRNA Mechanisms
Room: British / Columbia Ballroom

Speaker 7 of 7
Frank J. Slack, BIDMC Cancer Center/Harvard Medical School, USA
Short Talk: A Conserved miRNA regulates Timing of Neurotransmitter Synthesis and Axon Outgrowth

Saturday, January 28 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Saturday, January 28 | 11:30AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Saturday, January 28 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Saturday, January 28 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Saturday, January 28 | 5:00PM - 7:00PM
miRNA and Their Targets
Room: British / Columbia Ballroom

Speaker 1 of 5
* Andrew Fire, Stanford University, USA

Saturday, January 28 | 5:00PM - 7:00PM
miRNA and Their Targets
Room: British / Columbia Ballroom

Speaker 2 of 5
David P. Bartel, Massachusetts Institute of Technology and Whitehead Institute, USA
MicroRNA Targets and Functions in Animals and Plants

Saturday, January 28 | 5:00PM - 7:00PM
miRNA and Their Targets
Room: British / Columbia Ballroom

Speaker 3 of 5
Detlef Weigel, Max Planck Institute for Developmental Biology, Germany
Function and Specificity of Plant Micrornas: Insights from Whole-Genome Studies

Saturday, January 28 | 5:00PM - 7:00PM
miRNA and Their Targets
Room: British / Columbia Ballroom

Speaker 4 of 5
Nikolaus Rajewsky, Max Delbruck Center for Molecular Medicine, Germany
miRNA Targets: Identification, Conservation, Cell-Type Specific Signatures of microRNA on their mRNA Targets, and a System for in-vivo Validation

Saturday, January 28 | 5:00PM - 7:00PM
miRNA and Their Targets
Room: British / Columbia Ballroom

Speaker 5 of 5
Ronald H. Plasterk, Ministry of Education, Culture and Science, Netherlands

Saturday, January 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Saturday, January 28 | 7:30PM - 10:00PM
Poster Session 2
Room: Pacific Ballroom


Sunday, January 29 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Sunday, January 29 | 8:00AM - 11:30AM
RNAi: Immunity and Development
Room: British / Columbia Ballroom

Speaker 1 of 7
* Herve Vaucheret, Institut National de la Recherche Agronomique, France

Sunday, January 29 | 8:00AM - 11:30AM
RNAi: Immunity and Development
Room: British / Columbia Ballroom

Speaker 2 of 7
Andrew Fire, Stanford University, USA
Investigating Tumor-Related Changes in Small RNA Profile

Sunday, January 29 | 8:00AM - 11:30AM
RNAi: Immunity and Development
Room: British / Columbia Ballroom

Speaker 3 of 7
Christopher S. Sullivan, University of California, San Francisco, USA
Short Talk: Non-Homologous microRNAs in Two Different Polyomaviruses Share a Conserved Target and Function

Sunday, January 29 | 8:00AM - 11:30AM
RNAi: Immunity and Development
Room: British / Columbia Ballroom

Speaker 4 of 7
Eric C. Lai, Sloan Kettering Institute, USA
Short Talk: The Drosophila microRNA iab-4-5p has Homeotic Activity and Directly Represses Ultrabithorax

Sunday, January 29 | 8:00AM - 11:30AM
RNAi: Immunity and Development
Room: British / Columbia Ballroom

Speaker 5 of 7
James C. Carrington, Donald Danforth Plant Science Center, USA
Diversification of Small RNA Pathways in Plants

Sunday, January 29 | 8:00AM - 11:30AM
RNAi: Immunity and Development
Room: British / Columbia Ballroom

Speaker 6 of 7
Zhengying He, Northwestern University, USA
Short Talk: Structural Features of miRNA/miRNA* Duplexes that Specify Dicer-2-Independent RISC Assembly in Drosophila

Sunday, January 29 | 8:00AM - 11:30AM
RNAi: Immunity and Development
Room: British / Columbia Ballroom

Speaker 7 of 7
Shou-Wei Ding, University of California, Riverside, USA
Antiviral Silencing in Plants and Invertebrate Animals

Sunday, January 29 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Sunday, January 29 | 11:00AM - 1:00PM
Poster Setup
Room: Pacific Ballroom


Sunday, January 29 | 1:00PM - 10:00PM
Poster Viewing
Room: Pacific Ballroom


Sunday, January 29 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Sunday, January 29 | 5:00PM - 7:00PM
Structure and Function
Room: British / Columbia Ballroom

Speaker 1 of 5
* Traci M.T. Hall, NIEHS, National Institutes of Health, USA

Sunday, January 29 | 5:00PM - 7:00PM
Structure and Function
Room: British / Columbia Ballroom

Speaker 2 of 5
Phillip D. Zamore, University of Massachusetts Medical School, USA
Mechanism of Risc Assembly and Function

Sunday, January 29 | 5:00PM - 7:00PM
Structure and Function
Room: British / Columbia Ballroom

Speaker 3 of 5
Antonio J. Giraldez, Yale University School of Medicine, USA
Short Talk: Zebrafish miR340 accelerates target deadenylation & cleavage during maternal to zygotic transition

Sunday, January 29 | 5:00PM - 7:00PM
Structure and Function
Room: British / Columbia Ballroom

Speaker 4 of 5
David Barford, Institute of Cancer Research, UK
Studies of Argonaute Proteins: Central Mediators of RNA Silencing

Sunday, January 29 | 5:00PM - 7:00PM
Structure and Function
Room: British / Columbia Ballroom

Speaker 5 of 5
Dinshaw J. Patel, Memorial Sloan Kettering Cancer Center, USA
Insights into Protein-RNA Recognition Along the RISC-Loading Pathway from the Structure of A. aeolicus Argonaute with Externally-Bound siRNA

Sunday, January 29 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Sunday, January 29 | 7:30PM - 10:00PM
Poster Session 3
Room: Pacific Ballroom


Monday, January 30 | 7:00AM - 8:00AM
Breakfast
Room: Pacific Ballroom


Monday, January 30 | 8:00AM - 11:30AM
Mechanism and Applications
Room: British / Columbia Ballroom

Speaker 1 of 7
* Victor R. Ambros, University of Massachusetts, USA

Monday, January 30 | 8:00AM - 11:30AM
Mechanism and Applications
Room: British / Columbia Ballroom

Speaker 2 of 7
Michelle Carmell, Cold Spring Harbor Laboratory, USA
The Piwi Subfamily of Argonaute Proteins Interact with a Novel Class of Small RNA in Testes

Monday, January 30 | 8:00AM - 11:30AM
Mechanism and Applications
Room: British / Columbia Ballroom

Speaker 3 of 7
René Bernards, Netherlands Cancer Institute, Netherlands
Identification of Novel Cancer-Relevant Genes through Loss of Function Genetic Screens

Monday, January 30 | 8:00AM - 11:30AM
Mechanism and Applications
Room: British / Columbia Ballroom

Speaker 4 of 7
Judy Lieberman, Harvard University, USA
The Silent Treatment: Delivering RNA Interference

Monday, January 30 | 8:00AM - 11:30AM
Mechanism and Applications
Room: British / Columbia Ballroom

Speaker 5 of 7
Pamela A. Pavco, USA
Small Interfering RNA (siRNA) as Potential Therapy for Inhibition of Ocular Neovascularization

Monday, January 30 | 8:00AM - 11:30AM
Mechanism and Applications
Room: British / Columbia Ballroom

Speaker 6 of 7
Antonin de Fougerolles, Ablynx NV, Belgium
Therapeutic Silencing through Local and Systemic Delivery of Short Interfering RNA

Monday, January 30 | 8:00AM - 11:30AM
Mechanism and Applications
Room: British / Columbia Ballroom

Speaker 7 of 7
Tariq M. Rana, University of California, San Diego, USA
Short Talk: In vivo RNAi

Monday, January 30 | 9:20AM - 9:40AM
Coffee Break
Room: BC Foyer


Monday, January 30 | 4:30PM - 5:00PM
Coffee Available
Room: BC Foyer


Monday, January 30 | 5:00PM - 7:00PM
Transcriptional Silencing and Genomic Stability
Room: British / Columbia Ballroom

Speaker 1 of 5
* Phillip D. Zamore, University of Massachusetts Medical School, USA

Monday, January 30 | 5:00PM - 7:00PM
Transcriptional Silencing and Genomic Stability
Room: British / Columbia Ballroom

Speaker 2 of 5
Shiv I. S. Grewal, NCI, National Institutes of Health, USA
RNAi-Mediated Epigenetic Control of the Fission Yeast Genome

Monday, January 30 | 5:00PM - 7:00PM
Transcriptional Silencing and Genomic Stability
Room: British / Columbia Ballroom

Speaker 3 of 5
Sarah C.R. Elgin, Washington University, USA
Targeting Heterochromatin Formation in Drosophila

Monday, January 30 | 5:00PM - 7:00PM
Transcriptional Silencing and Genomic Stability
Room: British / Columbia Ballroom

Speaker 4 of 5
Steven E. Jacobsen, University of California, Los Angeles, USA
Genetic Analysis of DNA Methylation and Gene Silencing

Monday, January 30 | 5:00PM - 7:00PM
Transcriptional Silencing and Genomic Stability
Room: British / Columbia Ballroom

Speaker 5 of 5
Marc Bühler, Friedrich Miescher Institute for Biomedical Research, Switzerland
Short Talk: Tethering RITS to Drive Heterochromatin Formation

Monday, January 30 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Pacific Ballroom


Monday, January 30 | 8:00PM - 11:00PM
Entertainment
Room: Pacific Ballroom


Monday, January 30 | 8:00PM - 11:00PM
Cash Bar
Room: Pacific Ballroom


Tuesday, January 31 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.