Cardiac Arrhythmias: Linking Structural Biology to Gene Defects

Organizer(s): W. Jonathan Lederer and Robert S. Kass

Supported by The Director's Fund

For important information on the coronavirus, please click here

Summary of Meeting:

Cardiac arrhythmias are one of the leading causes of death world-wide. Recent studies of the causes of cardiac arrhythmias provide broad new understanding of the heart, providing novel remedies and new approaches for treatment. The new findings will be presented in a tightly integrated set of talks covering structural and molecular biology, cell biology and physiology and therapeutics and clinical approaches. The symposium will bring together a unique group with expertise in structural biology, molecular and systems physiology, and industrial approaches to target discovery and drug development. Newly identified protein structures provide insight into ion channel behavior and regulation. This work spans the behavior, structure and function of normal and disease-linked gene mutations of K+, Na+, Ca2+ , RyR and IP3R channels. In addition, macromolecular complexes have been identified and characterized and reveal how specific elements provide extraordinary local control of cardiac cellular signaling. The subcellular organization, dependent on cytoskeletal organization, has been shown to significantly contribute to the normal cell function and disease. New molecular and pharmacological approaches to treatment arise from this understanding.

Scholarship Deadline: September 28 2005

Discounted Abstract Deadline: September 28 2005

Abstract Deadline: October 20 2005

Discounted Registration Deadline: November 29 2005

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Merck Research Laboratories

NeuroSearch A/S

Sanofi US

We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13 HL083678-01

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations