Web Desc
Cardiac Arrhythmias: Linking Structural Biology to Gene Defects
Organizer(s): W. Jonathan Lederer and Robert S. Kass
Date: January 29 - February 03, 2006
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Supported by The Director's Fund
For important information on the coronavirus, please click here
Summary of Meeting:
Cardiac arrhythmias are one of the leading causes of death world-wide. Recent studies of the causes of cardiac arrhythmias provide broad new understanding of the heart, providing novel remedies and new approaches for treatment. The new findings will be presented in a tightly integrated set of talks covering structural and molecular biology, cell biology and physiology and therapeutics and clinical approaches. The symposium will bring together a unique group with expertise in structural biology, molecular and systems physiology, and industrial approaches to target discovery and drug development. Newly identified protein structures provide insight into ion channel behavior and regulation. This work spans the behavior, structure and function of normal and disease-linked gene mutations of K+, Na+, Ca2+ , RyR and IP3R channels. In addition, macromolecular complexes have been identified and characterized and reveal how specific elements provide extraordinary local control of cardiac cellular signaling. The subcellular organization, dependent on cytoskeletal organization, has been shown to significantly contribute to the normal cell function and disease. New molecular and pharmacological approaches to treatment arise from this understanding.
Scholarship Deadline: September 28 2005
Discounted Abstract Deadline: September 28 2005
Abstract Deadline: October 20 2005
Discounted Registration Deadline: November 29 2005
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Merck Research Laboratories

NeuroSearch A/S

Sanofi US
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13 HL083678-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, January 29 | 3:00PM - 7:30PM
Registration
Room: Pre-Function


Monday, January 30 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Monday, January 30 | 8:00AM - 11:00AM
Congenital and Acquired Arrhythmias: Clinical and Theoretica
l Basis

Room: Mountain

Speaker 1 of 4
* Silvia G. Priori, Foundation Salvatore Maugeri, Italy
Channel Mutations that Underlie Human Arrhythmogenesis.

Monday, January 30 | 8:00AM - 11:00AM
Congenital and Acquired Arrhythmias: Clinical and Theoretica
l Basis

Room: Mountain

Speaker 2 of 4
Denis Escande, University of Nantes, France
Functional Consequences of Scn5a Invalidation in the Mouse Heart

Monday, January 30 | 8:00AM - 11:00AM
Congenital and Acquired Arrhythmias: Clinical and Theoretica
l Basis

Room: Mountain

Speaker 3 of 4
Dan M. Roden, Vanderbilt University Medical Center, USA
Pharmacogenomic Basis Of Drug-Induced Arrhythmias

Monday, January 30 | 8:00AM - 11:00AM
Congenital and Acquired Arrhythmias: Clinical and Theoretica
l Basis

Room: Mountain

Speaker 4 of 4
Yoram Rudy, Washington University, USA
Modeling Cardiac Arrhythmias

Monday, January 30 | 9:20AM - 9:40AM
Coffee Break
Room: Pre-Function


Monday, January 30 | 11:00AM - 1:00PM
Poster Setup
Room: Lake


Monday, January 30 | 1:00PM - 10:00PM
Poster Viewing
Room: Lake


Monday, January 30 | 4:30PM - 5:00PM
Coffee Available
Room: Pre-Function


Monday, January 30 | 5:00PM - 7:00PM
Ca2+ Dynamics and Arrhythmogenesis
Room: Mountain

Speaker 1 of 3
Guy Salama, University of Pittsburgh, School of Medicine, USA
Sodium/Calcium Exchanger as a Molecular Determinant of Arrhythmias in Drug-Induced Long QT 2

Monday, January 30 | 5:00PM - 7:00PM
Ca2+ Dynamics and Arrhythmogenesis
Room: Mountain

Speaker 2 of 3
* W. Jonathan Lederer, University of Maryland Baltimore, USA
Subcellular Changes that Underlie Ca2+ Signaling Dysfunction

Monday, January 30 | 5:00PM - 7:00PM
Ca2+ Dynamics and Arrhythmogenesis
Room: Mountain

Speaker 3 of 3
Donald M. Bers, University of California, Davis, USA
Na-Ca Exchange, SR Ca Leak and Arrhythmogenesis

Monday, January 30 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Monday, January 30 | 8:00PM - 10:00PM
Poster Session 1
Room: Lake


Monday, January 30 | 8:00PM - 9:00PM
Social Hour
Room: Lake


Tuesday, January 31 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Tuesday, January 31 | 8:00AM - 11:00AM
K+ and Pacemaker Channels
Room: Mountain

Speaker 1 of 4
* Robert S. Kass, Columbia University, USA
K-and Na- Channel Dysfunction and Arrhythmogenesis

Tuesday, January 31 | 8:00AM - 11:00AM
K+ and Pacemaker Channels
Room: Mountain

Speaker 2 of 4
Barry London, University of Pittsburgh, USA
HERG Arrhythmogenesis


Tuesday, January 31 | 8:00AM - 11:00AM
K+ and Pacemaker Channels
Room: Mountain

Speaker 3 of 4
Steven A. Siegelbaum, Columbia University, USA
Cardiac HCN Channels: Regulatory Mechanisms

Tuesday, January 31 | 8:00AM - 11:00AM
K+ and Pacemaker Channels
Room: Mountain

Speaker 4 of 4
Michael C. Sanguinetti, University of Utah, USA
KCNQ1 and hERG Channels

Tuesday, January 31 | 9:20AM - 9:40AM
Coffee Break
Room: Pre-Function


Tuesday, January 31 | 4:30PM - 5:00PM
Coffee Available
Room: Pre-Function


Tuesday, January 31 | 5:00PM - 6:20PM
Na+ Channels
Room: Mountain

Speaker 1 of 2
* Alfred L. George, Jr., Vanderbilt University, USA
Sodium Channel Mutations and Inherited Arrhythmias

Tuesday, January 31 | 5:00PM - 6:20PM
Na+ Channels
Room: Mountain

Speaker 2 of 2
Gordon Tomaselli, Johns Hopkins School of Medicine, USA
Na Channels, Conduction and Arrhythmias

Tuesday, January 31 | 6:30PM - 7:30PM
Social Hour
Room: Lake


Tuesday, January 31 | 7:30PM - 8:30PM
Dinner
Room: Granhall


Wednesday, February 01 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Wednesday, February 01 | 8:00AM - 11:00AM
Ion Channel Modifiers and Arrhythmogenesis
Room: Mountain

Speaker 1 of 4
* Paul A. Insel, University of California, San Diego, USA
Caveolin-Enriched Signaling Domains and Cardiac GPCR Signal Transduction

Wednesday, February 01 | 8:00AM - 11:00AM
Ion Channel Modifiers and Arrhythmogenesis
Room: Mountain

Speaker 2 of 4
Peter J. Mohler, University of Iowa, USA
Dysfunction in Ankyrin-Based Pathways for Ion Channel/Transporter Targeting and Human Arrhythmia

Wednesday, February 01 | 8:00AM - 11:00AM
Ion Channel Modifiers and Arrhythmogenesis
Room: Mountain

Speaker 3 of 4
Walter J. Koch, Temple University School of Medicine, USA
Regulating Adrenergic and Calcium Signaling via Gene Therapy

Wednesday, February 01 | 8:00AM - 11:00AM
Ion Channel Modifiers and Arrhythmogenesis
Room: Mountain


Short Talks Chosen from Abstracts
Presenters to be Selected from Poster Display Contest

Wednesday, February 01 | 9:20AM - 9:40AM
Coffee Break
Room: Pre-Function


Wednesday, February 01 | 4:30PM - 5:00PM
Coffee Available
Room: Pre-Function


Wednesday, February 01 | 5:00PM - 7:00PM
Kinases
Room: Mountain

Speaker 1 of 3
Mark E. Anderson, Johns Hopkins University School of Medicine, USA
The Role of Calmodulin Kinase II in Arrhythmias

Wednesday, February 01 | 5:00PM - 7:00PM
Kinases
Room: Mountain

Speaker 2 of 3
* John D. Scott, University of Washington, USA
Molecular Architecture in Signal Transduction Complexes

Wednesday, February 01 | 5:00PM - 7:00PM
Kinases
Room: Mountain

Speaker 3 of 3
Geoffrey Pitt, Duke University, USA
Calcium Regulation of Diverse Ion Channels and Functions

Wednesday, February 01 | 7:00PM - 8:00PM
Social Hour
Room: Lake


Wednesday, February 01 | 8:00PM - 9:00PM
Dinner
Room: Granhall


Thursday, February 02 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Thursday, February 02 | 8:00AM - 11:00AM
Subcellular Channels and Arrhythmias
Room: Mountain

Speaker 1 of 4
Xander H.T. Wehrens, Baylor College of Medicine, USA
RyR Regulation and Arrhythmogenesis

Thursday, February 02 | 8:00AM - 11:00AM
Subcellular Channels and Arrhythmias
Room: Mountain

Speaker 2 of 4
Lothar A. Blatter, Rush University Chicago, USA
IP3 Receptors and Arrhythmogenesis

Thursday, February 02 | 8:00AM - 11:00AM
Subcellular Channels and Arrhythmias
Room: Mountain

Speaker 3 of 4
* Barbara E. Ehrlich, Yale University, USA
InsP3R Dependent Oscillations in Cardiac Cells

Thursday, February 02 | 8:00AM - 11:00AM
Subcellular Channels and Arrhythmias
Room: Mountain

Speaker 4 of 4
Elizabeth A. Woodcock, Baker IDI Heart and Diabetes Institute, Australia
IP3 Signaling in Heart

Thursday, February 02 | 9:20AM - 9:40AM
Coffee Break
Room: Pre-Function


Thursday, February 02 | 4:30PM - 5:00PM
Coffee Available
Room: Pre-Function


Thursday, February 02 | 5:00PM - 7:00PM
Channels as Molecular Targets: A Pharmaceutical Industry Per
spective

Room: Mountain

Speaker 1 of 3
* Maria L. Garcia, Merck Research Laboratories, USA
Rationale Design of Ion Channel Modulators

Thursday, February 02 | 5:00PM - 7:00PM
Channels as Molecular Targets: A Pharmaceutical Industry Per
spective

Room: Mountain

Speaker 2 of 3
Søren Peter Olesen, University of Copenhagen, Denmark
HERG Channel Activators as a New Anti-Arrhythmic Principle

Thursday, February 02 | 5:00PM - 7:00PM
Channels as Molecular Targets: A Pharmaceutical Industry Per
spective

Room: Mountain

Speaker 3 of 3
Klaus Steinmeyer, Sanofi-Aventis Deutschland GmbH, Germany
Kv1.5 Channel Blockers for the Treatment of Atrial Fibrillation

Thursday, February 02 | 7:00PM - 8:00PM
Social Hour
Room: Lake


Thursday, February 02 | 8:00PM - 9:00PM
Dinner
Room: Granhall


Thursday, February 02 | 8:00PM - 11:00PM
Entertainment
Room: Mountain/Lake Rooms


Thursday, February 02 | 8:00PM - 11:00PM
Cash Bar
Room: Mountain/Lake Rooms


Friday, February 03 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.