Web Desc
Innate Immunity
Organizer(s): Siamon Gordon and Albert S. Bendelac
Date: February 10 - 15, 2006
Location: Fairmont Banff Springs, Banff, AB, Canada
Supported by The Director's Fund
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Summary of Meeting:
The innate immune system is evolutionarily ancient, protecting the host during early stages of infectious challenge, and directing the subsequent adaptive immune response in higher organisms. The field has exploded in recent years, with insights into the role of different cell types and molecular mechanisms from recognition of pathogens to signal transduction and altered gene expression and functions. This meeting will feature some of the key investigators in the field who will present recent research on model systems, myeloid cell and natural lymphocyte receptors, TLR and other signalling pathways, and interactions with infectious agents and malignancy. The meeting will conclude with examples of how disorders of innate immunity can give rise to important diseases.
Scholarship Deadline: October 10 2005
Discounted Abstract Deadline: October 10 2005
Abstract Deadline: November 2 2005
Discounted Registration Deadline: December 9 2005
We gratefully acknowledge additional support for this conference from:
Novartis Institutes for BioMedical Research
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI066892-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, February 10 | 3:00PM - 7:30PM
Registration
Room: Van Horne Ballroom Foyer


Friday, February 10 | 6:30PM - 7:30PM
Refreshments
Room: Van Horne Ballroom Foyer


Friday, February 10 | 7:30PM - 8:30PM
Keynote Address: Innate Immune Recognition
Room: Van Horne Ballroom A

Speaker 1 of 1
Max D. Cooper, Emory University, USA
Evolution of Immune Receptors from Innate to Adaptive Immunity

Saturday, February 11 | 7:00AM - 8:00AM
Breakfast
Room: Alberta/New Brunswick


Saturday, February 11 | 8:00AM - 11:00AM
Innate Recognition in Model Systems
Room: Van Horne Ballroom A

Speaker 1 of 5
Jeffery L. Dangl, University of North Carolina at Chapel Hill, USA
Intracellular Disease Resistance Pathways in Arabidopsis

Saturday, February 11 | 8:00AM - 11:00AM
Innate Recognition in Model Systems
Room: Van Horne Ballroom A

Speaker 2 of 5
Cyril Zipfel, University of Zurich, Switzerland
Short Talk: Receptor Kinases as PAMP Receptors in Plants

Saturday, February 11 | 8:00AM - 11:00AM
Innate Recognition in Model Systems
Room: Van Horne Ballroom A

Speaker 3 of 5
Jonathan A. Hodgkin, University of Oxford, UK
Innate Immunity to Bacteria in C. elegans

Saturday, February 11 | 8:00AM - 11:00AM
Innate Recognition in Model Systems
Room: Van Horne Ballroom A

Speaker 4 of 5
Jules A. Hoffmann, Institute of Cellular and Molecular Biology, France
Receptors and Signaling Responses to Micro-Organisms in Drosophila

Saturday, February 11 | 8:00AM - 11:00AM
Innate Recognition in Model Systems
Room: Van Horne Ballroom A

Speaker 5 of 5
* Alan Ezekowitz, Abide Therapeutics, USA
Phagocytosis: From Flies to Man

Saturday, February 11 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Ballroom Foyer


Saturday, February 11 | 11:00AM - 1:00PM
Poster Setup
Room: Alberta/New Brunswick


Saturday, February 11 | 1:00PM - 10:00PM
Poster Viewing
Room: Alberta/New Brunswick


Saturday, February 11 | 2:30PM - 4:30PM
Workshop 1: Cells and Receptors
Room: Van Horne Ballroom A

Speaker 1 of 8
* Wendy L. Havran, The Scripps Research Institute, USA

Saturday, February 11 | 2:30PM - 4:30PM
Workshop 1: Cells and Receptors
Room: Van Horne Ballroom A

Speaker 2 of 8
Paul R. Crocker, University of Dundee, UK
Characterisation of Siglec-H as a Novel Endocytic Receptor of Murine Plasmacytoid Dendritic Cells

Saturday, February 11 | 2:30PM - 4:30PM
Workshop 1: Cells and Receptors
Room: Van Horne Ballroom A

Speaker 3 of 8
Roman Dziarski, Indiana University School of Medicine, USA
Peptidoglycan Recognition Proteins 3 and 4 are a New Class of Human Bactericidal Proteins

Saturday, February 11 | 2:30PM - 4:30PM
Workshop 1: Cells and Receptors
Room: Van Horne Ballroom A

Speaker 4 of 8
Min Xu, Genentech, Inc, USA
Peptidoglycan Recognition Protein-L Mediates Protection during Intestinal Epithelial Injury

Saturday, February 11 | 2:30PM - 4:30PM
Workshop 1: Cells and Receptors
Room: Van Horne Ballroom A

Speaker 5 of 8
Nicolas Anfossi, Innate Pharma, France
Educating Impact of Inhibitory MHC Class I Receptors on the Acquisition of Human NK Cell Function

Saturday, February 11 | 2:30PM - 4:30PM
Workshop 1: Cells and Receptors
Room: Van Horne Ballroom A

Speaker 6 of 8
Deborah N. Burshtyn, University of Alberta, Canada
Killer Cell Ig-like Receptor-Dependent Signaling by LILRB1

Saturday, February 11 | 2:30PM - 4:30PM
Workshop 1: Cells and Receptors
Room: Van Horne Ballroom A

Speaker 7 of 8
Yaqub Hanna, Whitehead Institute for Biomedical Research, USA
Novel Functions of Human NK cells Revealed by High-Throughput Proteomic and Genomic Analysis


Saturday, February 11 | 2:30PM - 4:30PM
Workshop 1: Cells and Receptors
Room: Van Horne Ballroom A

Speaker 8 of 8
† Mustapha Zeddou, University of Liege, Belgium
Prostanglandin E2 Induces the Expression of Functional Inhibitory CD94/NKG2A Receptors in Human CD8+ T Lymphocytes by a Camp-Dependent Protein Kinase A Type I Pathway

Saturday, February 11 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Ballroom Foyer


Saturday, February 11 | 5:00PM - 7:00PM
Toll-Like Receptors and their Signaling Pathways in Mammals
Room: Van Horne Ballroom A

Speaker 1 of 4
Bruce A. Beutler, University of Texas Southwestern Medical Center, USA
TLR Responses in ENU Mutagenized Mice

Saturday, February 11 | 5:00PM - 7:00PM
Toll-Like Receptors and their Signaling Pathways in Mammals
Room: Van Horne Ballroom A

Speaker 2 of 4
Douglas Golenbock, University of Massachusetts Medical School, USA
Ligand Binding Results in Sequential Conformational Change and dimerisation of TLR9

Saturday, February 11 | 5:00PM - 7:00PM
Toll-Like Receptors and their Signaling Pathways in Mammals
Room: Van Horne Ballroom A

Speaker 3 of 4
Taro Kawai, Osaka University, Japan
Short Talk: IPS-1: An Adaptor Triggering RIG-I- and Mda5-Dependent Type I IFN Induction

Saturday, February 11 | 5:00PM - 7:00PM
Toll-Like Receptors and their Signaling Pathways in Mammals
Room: Van Horne Ballroom A

Speaker 4 of 4
* Richard Joel Ulevitch, 5AM Ventures, USA
The Many Faces of Innate Immunity from Infection to Malignancy

Saturday, February 11 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Alberta/New Brunswick


Saturday, February 11 | 7:30PM - 10:00PM
Poster Session 1
Room: Alberta/New Brunswick


Sunday, February 12 | 7:00AM - 8:00AM
Breakfast
Room: Alberta/New Brunswick


Sunday, February 12 | 8:00AM - 11:00AM
Non-Toll Recognition of Micro-Organisms
Room: Van Horne Ballroom A

Speaker 1 of 5
Yvette van Kooyk, Vrije University Medical Center, Netherlands
C-type lectins and pathogen interactions

Sunday, February 12 | 8:00AM - 11:00AM
Non-Toll Recognition of Micro-Organisms
Room: Van Horne Ballroom A

Speaker 2 of 5
Gordon D. Brown, University of Aberdeen, UK
Dectin-1 and Fungal Recognition

Sunday, February 12 | 8:00AM - 11:00AM
Non-Toll Recognition of Micro-Organisms
Room: Van Horne Ballroom A

Speaker 3 of 5
* Siamon Gordon, Chang Gung University / University of Oxford, UK
Scavenger Receptors and Microbial Recognition

Sunday, February 12 | 8:00AM - 11:00AM
Non-Toll Recognition of Micro-Organisms
Room: Van Horne Ballroom A

Speaker 4 of 5
Marco Colonna, Washington University School of Medicine, USA
The Opposing Functions of TREM/DAP12 in Innate Immune Response

Sunday, February 12 | 8:00AM - 11:00AM
Non-Toll Recognition of Micro-Organisms
Room: Van Horne Ballroom A

Speaker 5 of 5
Jessica K. Bell, Virginia Commonwealth University, USA
Short Talk: The Structure of Toll-Like Receptor 3 Ligand Binding Domain

Sunday, February 12 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Ballroom Foyer


Sunday, February 12 | 11:00AM - 1:00PM
Poster Setup
Room: Alberta/New Brunswick


Sunday, February 12 | 1:00PM - 10:00PM
Poster Viewing
Room: Alberta/New Brunswick


Sunday, February 12 | 2:30PM - 4:30PM
Workshop 2: Signaling and Cellular Responses
Room: Van Horne Ballroom A

Speaker 1 of 8
* Kate A. Fitzgerald, University of Massachusetts Medical School, USA

Sunday, February 12 | 2:30PM - 4:30PM
Workshop 2: Signaling and Cellular Responses
Room: Van Horne Ballroom A

Speaker 2 of 8
Suzanne S. Bohlson, University of California, Irvine, USA
CD93 Cleavage Products in Inflammation and Phagocytosis

Sunday, February 12 | 2:30PM - 4:30PM
Workshop 2: Signaling and Cellular Responses
Room: Van Horne Ballroom A

Speaker 3 of 8
Tracie A. Seimon, Columbia University, USA
Scavenger Receptor-A Ligands Alter TLR4 Signaling to Promote Apoptosis in ER-Stressed Macrophages

Sunday, February 12 | 2:30PM - 4:30PM
Workshop 2: Signaling and Cellular Responses
Room: Van Horne Ballroom A

Speaker 4 of 8
Thomas A. Kufer, University of Hohenheim, Germany
Screening for Interaction Partners of the Human NACHT-LRR Proteins Nod1 and Nod2

Sunday, February 12 | 2:30PM - 4:30PM
Workshop 2: Signaling and Cellular Responses
Room: Van Horne Ballroom A

Speaker 5 of 8
Oystein Sandanger, Norwegian University of Science and Technology, Norway
Characterization of MD-2 Localization and Expression using a Newly Developed Monoclonal Antibody

Sunday, February 12 | 2:30PM - 4:30PM
Workshop 2: Signaling and Cellular Responses
Room: Van Horne Ballroom A

Speaker 6 of 8
Lee M. Shaughnessy, University of Michigan, USA
Protein Kinase C Epsilon Activation to Vacuolar Perforation by Listeria monocytogenes in Macrophages

Sunday, February 12 | 2:30PM - 4:30PM
Workshop 2: Signaling and Cellular Responses
Room: Van Horne Ballroom A

Speaker 7 of 8
Lynda M. Stuart, Bill & Melinda Gates Foundation, USA
Using Systems Biology to Examine the Drosophila Phagosome and Define the Basic Template of Phagocytosis

Sunday, February 12 | 2:30PM - 4:30PM
Workshop 2: Signaling and Cellular Responses
Room: Van Horne Ballroom A

Speaker 8 of 8
Emre E. Turer, University of Texas Southwestern, USA
The Ubiquitin-Modifying Enzyme A20 is Required for Termination of Toll-Like Receptor Responses in vivo

Sunday, February 12 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Ballroom Foyer


Sunday, February 12 | 5:00PM - 7:00PM
Sensing Signals within the Cell
Room: Van Horne Ballroom A

Speaker 1 of 3
Fabio Martinon, Harvard School of Public Health, USA
NLRs Join TLRs as Innate Sensors

Sunday, February 12 | 5:00PM - 7:00PM
Sensing Signals within the Cell
Room: Van Horne Ballroom A

Speaker 2 of 3
Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA
Ubiquitin Signaling in the NF-kappaB Pathway

Sunday, February 12 | 5:00PM - 7:00PM
Sensing Signals within the Cell
Room: Van Horne Ballroom A

Speaker 3 of 3
* Gabriel Nuñez, University of Michigan, USA
The NOD-LRR Protein Family: Role in Immunity and Disease

Sunday, February 12 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Alberta/New Brunswick


Sunday, February 12 | 7:30PM - 10:00PM
Poster Session 2
Room: Alberta/New Brunswick


Monday, February 13 | 7:00AM - 8:00AM
Breakfast
Room: Alberta/New Brunswick


Monday, February 13 | 8:00AM - 11:00AM
Cellular Responses and Host-Pathogen Interactions
Room: Van Horne Ballroom A

Speaker 1 of 5
* Alan Aderem, Center for Infectious Disease Research, USA
A Systems Approach to Dissecting Immunity

Monday, February 13 | 8:00AM - 11:00AM
Cellular Responses and Host-Pathogen Interactions
Room: Van Horne Ballroom A

Speaker 2 of 5
Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
TLR's, Phagosome Maturation and Self/Non-self Discrimination

Monday, February 13 | 8:00AM - 11:00AM
Cellular Responses and Host-Pathogen Interactions
Room: Van Horne Ballroom A

Speaker 3 of 5
Rong-Fu Wang, Baylor College of Medicine, USA
Short Talk: Functional Control of Suppressive Function of Regulatory
T Cells by Toll-Like Receptor Signaling


Monday, February 13 | 8:00AM - 11:00AM
Cellular Responses and Host-Pathogen Interactions
Room: Van Horne Ballroom A

Speaker 4 of 5
Michele S. Swanson, University of Michigan Medical School, USA
A NOD to Inflammatory Cell Death: Murine Macrophages Restrict Legionella Infedtion by Detecting Cytosolic Flagellin

Monday, February 13 | 8:00AM - 11:00AM
Cellular Responses and Host-Pathogen Interactions
Room: Van Horne Ballroom A

Speaker 5 of 5
Samuel I. Miller, University of Washington, USA
Bacterial Recognition of Innate Immunity Molecules to Promote Virulence

Monday, February 13 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Ballroom Foyer


Monday, February 13 | 11:00AM - 1:00PM
Poster Setup
Room: Alberta/New Brunswick


Monday, February 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Alberta/New Brunswick


Monday, February 13 | 2:30PM - 4:30PM
Workshop 3: Innate Cell Pathogen Interactions and Adaptive I
mmunity
Room: Van Horne Ballroom A

Speaker 1 of 6
* Anne O'Garra, Francis Crick Institute, UK
Regulation of IL -10 Production in Macrophages and Dendriric Cells

Monday, February 13 | 2:30PM - 4:30PM
Workshop 3: Innate Cell Pathogen Interactions and Adaptive I
mmunity
Room: Van Horne Ballroom A

Speaker 2 of 6
Sophie Chabot, USA
TLR2 Promotes Capture of Proteosome-Based Vaccines by Dendritic Cells in Organized Mucosal Lymphoid Tissues

Monday, February 13 | 2:30PM - 4:30PM
Workshop 3: Innate Cell Pathogen Interactions and Adaptive I
mmunity
Room: Van Horne Ballroom A

Speaker 3 of 6
Laure Gurcel, University of Geneva, Switzerland
Cholesterol Biosynthesis as a Survival Mechnism to Pore-Forming Bacterial Toxins

Monday, February 13 | 2:30PM - 4:30PM
Workshop 3: Innate Cell Pathogen Interactions and Adaptive I
mmunity
Room: Van Horne Ballroom A

Speaker 4 of 6
Adam J. Ratner, New York University School of Medicine, USA
Epithelial Innate Immune Responses to Polymicrobial Stimulation are Mediated by Entry of Peptidoglycan Fragments through Toxin Pores

Monday, February 13 | 2:30PM - 4:30PM
Workshop 3: Innate Cell Pathogen Interactions and Adaptive I
mmunity
Room: Van Horne Ballroom A

Speaker 5 of 6
Marie Charrel-Dennis, Florida State University, USA
Recognition of Group B streptococcus by Toll Like Receptors

Monday, February 13 | 2:30PM - 4:30PM
Workshop 3: Innate Cell Pathogen Interactions and Adaptive I
mmunity
Room: Van Horne Ballroom A

Speaker 6 of 6
Philip R. Taylor, Cardiff University School of Medicine, UK
Fungal Susceptibility and Defective Myeloid Cell Activation in Dectin-1-Deficient Mice

Monday, February 13 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Ballroom Foyer


Monday, February 13 | 5:00PM - 7:00PM
Regulation of Innate Immunity to Microbial Infection
Room: Van Horne Ballroom A

Speaker 1 of 4
Wayne M. Yokoyama, Washington University School of Medicine, USA
Role of Natural Killer Cells in Innate Ant-Viral Defense

Monday, February 13 | 5:00PM - 7:00PM
Regulation of Innate Immunity to Microbial Infection
Room: Van Horne Ballroom A

Speaker 2 of 4
Yasmina Laouar, University of Michigan, USA
Short Talk: Effects of TGF-beta on NK Cells: Outcomes on TH1 Cell Differentiation

Monday, February 13 | 5:00PM - 7:00PM
Regulation of Innate Immunity to Microbial Infection
Room: Van Horne Ballroom A

Speaker 3 of 4
* Christine A. Biron, Brown University, USA
Cellular Responses to Viral Infection: DC, NK Cell and Macrophage Interactions in Shaping Innate Cytokine Production

Monday, February 13 | 5:00PM - 7:00PM
Regulation of Innate Immunity to Microbial Infection
Room: Van Horne Ballroom A

Speaker 4 of 4
Daniel M. Davis, Imperial College London, UK
Innate Immune Cell Synapses

Monday, February 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Alberta/New Brunswick


Monday, February 13 | 7:30PM - 10:00PM
Poster Session 3
Room: Alberta/New Brunswick


Tuesday, February 14 | 7:00AM - 8:00AM
Breakfast
Room: Alberta/New Brunswick


Tuesday, February 14 | 8:00AM - 11:00AM
Recognition Mechanisms of Innate-Like Lymphocytes
Room: Van Horne Ballroom A

Speaker 1 of 4
Luc Teyton, The Scripps Research Institute, USA
From Bacterial Wall to the CD1 Groove: the Journey of Bacterial Lipids

Tuesday, February 14 | 8:00AM - 11:00AM
Recognition Mechanisms of Innate-Like Lymphocytes
Room: Van Horne Ballroom A

Speaker 2 of 4
Michael B. Brenner, Harvard Medical School, USA
Antigen Presentation: CD1 Style

Tuesday, February 14 | 8:00AM - 11:00AM
Recognition Mechanisms of Innate-Like Lymphocytes
Room: Van Horne Ballroom A

Speaker 3 of 4
* Albert S. Bendelac, University of Chicago, USA
Exogenous and Endogenous Glycolipid Antigens Activate NKT Cells during Microbial Infections

Tuesday, February 14 | 8:00AM - 11:00AM
Recognition Mechanisms of Innate-Like Lymphocytes
Room: Van Horne Ballroom A

Speaker 4 of 4
Adrian C. Hayday, King's College London School of Medicine, UK
Unconventional T Cells and Tumor Surveillance

Tuesday, February 14 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Ballroom Foyer


Tuesday, February 14 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Ballroom Foyer


Tuesday, February 14 | 5:00PM - 7:00PM
Innate Control of Adaptive Effector Mechanisms
Room: Van Horne Ballroom A

Speaker 1 of 3
David H. Raulet, University of California, Berkeley, USA
Regulation of NK Cell Recognition and Self Tolerance

Tuesday, February 14 | 5:00PM - 7:00PM
Innate Control of Adaptive Effector Mechanisms
Room: Van Horne Ballroom A

Speaker 2 of 3
Bana Jabri, University of Chicago, USA
Regulation of Tissue Effector T Cells by NKG2 Receptors ans K15

Tuesday, February 14 | 5:00PM - 7:00PM
Innate Control of Adaptive Effector Mechanisms
Room: Van Horne Ballroom A

Speaker 3 of 3
* Veronika Groh-Spies, Fred Hutchinson Cancer Research Center, USA
NKG2D-dependent Negative T Cell Modulation in Tumor Immunity

Tuesday, February 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Cascade / Conservatory


Tuesday, February 14 | 8:00PM - 11:00PM
Entertainment
Room: Cascade / Conservatory


Tuesday, February 14 | 8:00PM - 11:00PM
Cash Bar
Room: Cascade / Conservatory


Wednesday, February 15 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.