Web Desc
G Protein-Coupled Receptors: Evolving Concepts and New Techniques
Organizer(s): Paul A. Insel, Graeme Milligan and Dianne M. Perez
Date: February 12 - 17, 2006
Location: Keystone Resort, Keystone, CO, USA
Supported by The Director's Fund
Summary of Meeting:
G-protein-coupled receptors (GPCRs), which comprise one of the largest gene families identified in the human genome, also represent the largest number of currently used targets of therapeutic drugs. Recent work has indicated a number of intriguing observations in terms of GPCR structure, function and regulation, including existence of receptor homodimers and heterodimers, genetic identification of orphan GPCRs, novel receptor interacting proteins, mechanisms involved in receptor deactivation/desensitization, and receptor targeting/action in signalling microdomains. Definitive information about each of these topics is still being developed. This symposium will focus on these and related topics with an emphasis on use of new tools, e.g., bioinformatic approaches to evaluate GPCR family members, novel strategies to identify ligands active at GPCRs, and insights from non-mammalian/lower eukaryotic systems.
Scholarship Deadline: October 12 2005
Discounted Abstract Deadline: October 12 2005
Abstract Deadline: November 3 2005
Discounted Registration Deadline: December 12 2005
We gratefully acknowledge additional support for this conference from:
Educational donation provided by AmgenNovartis Institutes for BioMedical Research
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 12 | 3:00PM - 7:30PM
Registration
Room: Shavano Peak Foyer


Sunday, February 12 | 6:30PM - 7:30PM
Refreshments
Room: Shavano Peak Foyer


Sunday, February 12 | 7:30PM - 8:30PM
Keynote Address
Room: RedCloud/Shavano

Speaker 1 of 2
* Paul A. Insel, University of California, San Diego, USA

Sunday, February 12 | 7:30PM - 8:30PM
Keynote Address
Room: RedCloud/Shavano

Speaker 2 of 2
Charles S. Zuker, HHMI, Columbia University, USA
Molecular Approaches for the Study of Taste Recepters

Monday, February 13 | 7:00AM - 8:00AM
Breakfast
Room: Torreys 1-4


Monday, February 13 | 8:00AM - 11:15AM
GPCR Structure
Room: RedCloud/Shavano

Speaker 1 of 6
Jean-Philippe Pin, Montpellier University, France
Asymmetric functioning of GPCR dimers

Monday, February 13 | 8:00AM - 11:15AM
GPCR Structure
Room: RedCloud/Shavano

Speaker 2 of 6
Jean-Louis Banères, CNRS - UMR5247 IBMM, France
Molecular Mechanisms of Activation of GPCRs

Monday, February 13 | 8:00AM - 11:15AM
GPCR Structure
Room: RedCloud/Shavano

Speaker 3 of 6
Edward C. Hulme, National Institute for Medical Research, UK
The Structure and Function of Muscarinic Cholinergic Receptors

Monday, February 13 | 8:00AM - 11:15AM
GPCR Structure
Room: RedCloud/Shavano

Speaker 4 of 6
Laurence J. Miller, Mayo Clinic, USA
GPCR Structures: Lessons from the Cholecystokinin Receptor

Monday, February 13 | 8:00AM - 11:15AM
GPCR Structure
Room: RedCloud/Shavano

Speaker 5 of 6
Marissa L. Matsumoto, Washington University School of Medicine, USA
Short Talk: A Comprehensive Genetic Map of the Intracellular Surface of the Human C5a Receptor

Monday, February 13 | 8:00AM - 11:15AM
GPCR Structure
Room: RedCloud/Shavano

Speaker 6 of 6
Paul S.H. Park, Case Western Reserve University, USA
Short Talk: Unfolding Pathways of the Light Receptor Rhodopsin Revealed By Single-Molecule Force Spectroscopy

Monday, February 13 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Monday, February 13 | 11:15AM - 1:00PM
Poster Setup
Room: Torreys Peak 1-4


Monday, February 13 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys Peak 1-4


Monday, February 13 | 4:00PM - 4:30PM
Coffee Available
Room: Shavano Peak Foyer


Monday, February 13 | 4:30PM - 7:00PM
GPCR/G-Protein Interaction
Room: RedCloud/Shavano

Speaker 1 of 6
Martin J. Lohse, Max Delbrück Center for Molecular Medicine, Germany
GPCR Activation: Studies with FRET

Monday, February 13 | 4:30PM - 7:00PM
GPCR/G-Protein Interaction
Room: RedCloud/Shavano

Speaker 2 of 6
* Heidi E. Hamm, USA

Monday, February 13 | 4:30PM - 7:00PM
GPCR/G-Protein Interaction
Room: RedCloud/Shavano

Speaker 3 of 6
William M. Oldham, Brigham and Women's Hospital, USA
How do GPCRs Catalyze G Protein Activation?

Monday, February 13 | 4:30PM - 7:00PM
GPCR/G-Protein Interaction
Room: RedCloud/Shavano

Speaker 4 of 6
Eric R. Prossnitz, University of New Mexico, USA
Estrogen-mediated Signaling via GPR30

Monday, February 13 | 4:30PM - 7:00PM
GPCR/G-Protein Interaction
Room: RedCloud/Shavano

Speaker 5 of 6
Douglas P. Gladue, Stony Brook University, USA
Short Talk: A Site Directed Chemical Crosslinking Approach for Mapping the Interface between Receptor and G Protein

Monday, February 13 | 4:30PM - 7:00PM
GPCR/G-Protein Interaction
Room: RedCloud/Shavano

Speaker 6 of 6
Marie Mi Bonde, Institute for Neuroscience and Pharmacology, Denmark
Short Talk: Molecular Determinants of G-Protein Coupled Receptor Activation

Monday, February 13 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys Peak 1-4


Monday, February 13 | 7:30PM - 10:00PM
Poster Session 1
Room: Torreys Peak 1-4


Tuesday, February 14 | 7:00AM - 8:00AM
Breakfast
Room: Torreys 1-4


Tuesday, February 14 | 8:00AM - 11:30AM
GPCR Dimerization
Room: RedCloud/Shavano

Speaker 1 of 6
* Graeme Milligan, University of Glasgow, UK

Tuesday, February 14 | 8:00AM - 11:30AM
GPCR Dimerization
Room: RedCloud/Shavano

Speaker 2 of 6
Wayne A. Hendrickson, Columbia University, USA
Structural Studies on Receptors for Follicle Stimulating Hormone and for Serotonin

Tuesday, February 14 | 8:00AM - 11:30AM
GPCR Dimerization
Room: RedCloud/Shavano

Speaker 3 of 6
Michel Bouvier, University of Montreal, Canada
Oligomeric and Modular Protein Assemblies in 7TM Receptor Signaling

Tuesday, February 14 | 8:00AM - 11:30AM
GPCR Dimerization
Room: RedCloud/Shavano

Speaker 4 of 6
Susan R. George, University of Toronto, Canada
Implications of Heterooligomerization of Dopamine Receptors: Novel Insights into Function

Tuesday, February 14 | 8:00AM - 11:30AM
GPCR Dimerization
Room: RedCloud/Shavano

Speaker 5 of 6
Lakshmi A. Devi, Mount Sinai School of Medicine, USA
Opioid receptor dimerization: signaling, analgesia and addiction

Tuesday, February 14 | 8:00AM - 11:30AM
GPCR Dimerization
Room: RedCloud/Shavano

Speaker 6 of 6
Juan F. Lopez-Gimenez, IBLS,University of Glasgow, UK
Short Talk: Molecular Organization of the Alpha1b-Adrenoceptor Probed using Sequential Three Color Fluorescent Resonance Energy Transfer: Implications for Receptor Function

Tuesday, February 14 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Tuesday, February 14 | 11:30AM - 1:00PM
Poster Setup
Room: Torreys Peak 1-4


Tuesday, February 14 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys Peak 1-4


Tuesday, February 14 | 4:00PM - 4:30PM
Coffee Available
Room: Shavano Peak Foyer


Tuesday, February 14 | 4:30PM - 7:00PM
Orphan GPCRs
Room: RedCloud/Shavano

Speaker 1 of 6
* Susan R. George, University of Toronto, Canada

Tuesday, February 14 | 4:30PM - 7:00PM
Orphan GPCRs
Room: RedCloud/Shavano

Speaker 2 of 6
Robert Fredriksson, Uppsala University, Sweden
Evoulution of the GPCR family

Tuesday, February 14 | 4:30PM - 7:00PM
Orphan GPCRs
Room: RedCloud/Shavano

Speaker 3 of 6
Gozoh Tsujimoto, Kyoto University, Japan
GPR120 and Family of Fatty Acid Binding GPCRs

Tuesday, February 14 | 4:30PM - 7:00PM
Orphan GPCRs
Room: RedCloud/Shavano

Speaker 4 of 6
Ruben Abagyan, University of California, San Diego, USA
Predicting Biomolecular Interactions

Tuesday, February 14 | 4:30PM - 7:00PM
Orphan GPCRs
Room: RedCloud/Shavano

Speaker 5 of 6
Hans Bräuner-Osborne, University of Copenhagen, Denmark
Short Talk: Deorphanization of GPRC6A: A Receptor with Preference for Basic L-alpha-Amino Acids

Tuesday, February 14 | 4:30PM - 7:00PM
Orphan GPCRs
Room: RedCloud/Shavano

Speaker 6 of 6
Ralf Jockers, Institute Cochin, France
Short Talk: The Orphan GPR50 Receptor Specifically Antagonizes MT1 Melatonin Receptor Function through Heterodimerization

Tuesday, February 14 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys Peak 1-4


Tuesday, February 14 | 7:30PM - 10:00PM
Poster Session 2
Room: Torreys Peak 1-4


Wednesday, February 15 | 7:00AM - 8:00AM
Breakfast
Room: Torreys 1-4


Wednesday, February 15 | 8:00AM - 11:15AM
GPCR Knockouts and Mouse Models
Room: RedCloud/Shavano

Speaker 1 of 7
* Dianne M. Perez, Cleveland Clinic Foundation, USA

Wednesday, February 15 | 8:00AM - 11:15AM
GPCR Knockouts and Mouse Models
Room: RedCloud/Shavano

Speaker 2 of 7
Jürgen Wess, NIDDK, National Institutes of Health, USA
Muscarinic Acetylcholine Receptor Knockout Mice: Novel Phenotypes

Wednesday, February 15 | 8:00AM - 11:15AM
GPCR Knockouts and Mouse Models
Room: RedCloud/Shavano

Speaker 3 of 7
Bruce R. Conklin, University of California, San Francisco, USA
Designing New GPCRs to RASSL with in vivo Responses

Wednesday, February 15 | 8:00AM - 11:15AM
GPCR Knockouts and Mouse Models
Room: RedCloud/Shavano

Speaker 4 of 7
Paul C. Simpson, VA Medical Center & University of California, San Francisco, USA
Insights from Adrenergic Receptor Knockouts

Wednesday, February 15 | 8:00AM - 11:15AM
GPCR Knockouts and Mouse Models
Room: RedCloud/Shavano

Speaker 5 of 7
Stefan Offermanns, Universität Heidelberg, Germany
Nicotinic Acid Receptor - Pharmacological and Physiological Functions

Wednesday, February 15 | 8:00AM - 11:15AM
GPCR Knockouts and Mouse Models
Room: RedCloud/Shavano

Speaker 6 of 7
Richard Torres, Regeneron Pharmaceuticals Inc., USA
Short Talk: Age-Related Balance Impairment in Mice Lacking VG1037, an Orphan GPCR Localized to Brain Motor Systems

Wednesday, February 15 | 8:00AM - 11:15AM
GPCR Knockouts and Mouse Models
Room: RedCloud/Shavano

Speaker 7 of 7
Javier González-Maeso, Mount Sinai School of Medicine, USA
Short Talk: Agonist-Directed Trafficking of 5-HT2A Receptor Signaling: Selective Cellular and Behavioral Response Induced by Hallucinogenic Drugs

Wednesday, February 15 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Wednesday, February 15 | 11:00AM - 1:00PM
Poster Setup
Room: Torreys Peak 1-4


Wednesday, February 15 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys Peak 1-4


Wednesday, February 15 | 4:00PM - 4:30PM
Coffee Available
Room: Shavano Peak Foyer


Wednesday, February 15 | 4:30PM - 7:15PM
GPCR Desensitization and Turnover
Room: RedCloud/Shavano

Speaker 1 of 8
* Michel Bouvier, University of Montreal, Canada

Wednesday, February 15 | 4:30PM - 7:15PM
GPCR Desensitization and Turnover
Room: RedCloud/Shavano

Speaker 2 of 8
Jeffrey L. Benovic, Thomas Jefferson University, USA
Regulation of GPCR Endocytosis by Arrestins: A role for PI

Wednesday, February 15 | 4:30PM - 7:15PM
GPCR Desensitization and Turnover
Room: RedCloud/Shavano

Speaker 3 of 8
Jennifer L. Whistler, University of California, San Francisco, USA
RAVE, Trafficking, and Addiction: A GPCRS Journey

Wednesday, February 15 | 4:30PM - 7:15PM
GPCR Desensitization and Turnover
Room: RedCloud/Shavano

Speaker 4 of 8
Marc G. Caron, Duke University Medical Center, USA
A Role for the G protein-Coupled Receptor Kinase 2 (GRK2) in the Hedgehog/Patched/Smoothened Signaling Pathway

Wednesday, February 15 | 4:30PM - 7:15PM
GPCR Desensitization and Turnover
Room: RedCloud/Shavano

Speaker 5 of 8
Laura R. Johnson, Medical Research Council, UK
Short Talk: Nuclear Localization of the GRK4 Subfamily of GRKs

Wednesday, February 15 | 4:30PM - 7:15PM
GPCR Desensitization and Turnover
Room: RedCloud/Shavano

Speaker 6 of 8
Nicola J. Smith, Victor Chang Cardiac Research Institute, Australia
Short Talk: Beta-Arrestin-Dependent Erk1/2 Activation is Not Required for Epidermal Growth Factor Receptor Transactivation or Hypertrophy in Cardiomyocytes

Wednesday, February 15 | 4:30PM - 7:15PM
GPCR Desensitization and Turnover
Room: RedCloud/Shavano

Speaker 7 of 8
Aliesha Araceli González-Arenas, Instituto de Fisiología Celular UNAM, Mexico
Short Talk: Estrogens Regulate alpha1b-Adrenergic Receptors Through Signalplex Formation

Wednesday, February 15 | 4:30PM - 7:15PM
GPCR Desensitization and Turnover
Room: RedCloud/Shavano

Speaker 8 of 8
Faiza Baameur, University of Texas Health Science Center, USA
Short Talk: Rates of Dephosphorylation of â2-Adrenergic Receptor PKA and GRK Sites; Dissociation from Resensitization

Wednesday, February 15 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys Peak 1-4


Wednesday, February 15 | 7:30PM - 10:00PM
Poster Session 3
Room: Torreys Peak 1-4


Thursday, February 16 | 7:00AM - 8:00AM
Breakfast
Room: Torreys 1-4


Thursday, February 16 | 8:00AM - 11:00AM
GPCRs in Sensation and Inflammation
Room: RedCloud/Shavano

Speaker 1 of 6
* Jean-Philippe Pin, Montpellier University, France

Thursday, February 16 | 8:00AM - 11:00AM
GPCRs in Sensation and Inflammation
Room: RedCloud/Shavano

Speaker 2 of 6
Thomas E. Angel, Pacific Northwest National Laboratory, USA
Antibody Imprinting- using an Anti-rhodopsin Antibody to Study Protein Surface Structure

Thursday, February 16 | 8:00AM - 11:00AM
GPCRs in Sensation and Inflammation
Room: RedCloud/Shavano

Speaker 3 of 6
Sarah Spiegel, Virginia Commonwealth University, USA
Sphingosine-1-Phosphate Receptors in Allergy and Inflammation

Thursday, February 16 | 8:00AM - 11:00AM
GPCRs in Sensation and Inflammation
Room: RedCloud/Shavano

Speaker 4 of 6
Richard D. Ye, University of Illinois, USA
Leukocyte Chemoattractant Receptors and Inflammatory Cytokine Expression


Thursday, February 16 | 8:00AM - 11:00AM
GPCRs in Sensation and Inflammation
Room: RedCloud/Shavano

Speaker 5 of 6
Ingrid Langer, Université Libre de Bruxelles, Belgium
Short Talk: New Mechanism of CCK2R Regulation through Direct Interaction with RGS2

Thursday, February 16 | 8:00AM - 11:00AM
GPCRs in Sensation and Inflammation
Room: RedCloud/Shavano

Speaker 6 of 6
Richard W. Roberts, University of Southern California, USA
Short Talk: Extension of Drosophila Lifespan using a Selected Peptide Inhibitors of the Methuselah G Protein-Coupled Receptor

Thursday, February 16 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Thursday, February 16 | 4:00PM - 4:30PM
Coffee Available
Room: Shavano Peak Foyer


Thursday, February 16 | 4:30PM - 7:00PM
GPCRs and Human Disease
Room: RedCloud/Shavano

Speaker 1 of 6
* Paul A. Insel, University of California, San Diego, USA

Thursday, February 16 | 4:30PM - 7:00PM
GPCRs and Human Disease
Room: RedCloud/Shavano

Speaker 2 of 6
Gilbert Vassart, Université Libre de Bruxelles, Belgium
Glycoprotein Hormone Receptors: From Natural Variants to Structure and Function

Thursday, February 16 | 4:30PM - 7:00PM
GPCRs and Human Disease
Room: RedCloud/Shavano

Speaker 3 of 6
Sheila Collins, Vanderbilt University Medical Center, USA
Adipocyte beta-ARs: Signaling Networks Linking PKA and MAPKs Regulating Metabolism and Thermogenesis

Thursday, February 16 | 4:30PM - 7:00PM
GPCRs and Human Disease
Room: RedCloud/Shavano

Speaker 4 of 6
Roger D. Cone, University of Michigan, USA
Melanocortin Receptor Signaling

Thursday, February 16 | 4:30PM - 7:00PM
GPCRs and Human Disease
Room: RedCloud/Shavano

Speaker 5 of 6
Holger Römpler, Max Planck Institute for Evolutionary Anthropology, Germany
Short Talk: Functional Analysis of a Complete Nuclear Genome from Pleistocene Mammoth

Thursday, February 16 | 4:30PM - 7:00PM
GPCRs and Human Disease
Room: RedCloud/Shavano

Speaker 6 of 6
Zhaohui Jin, Children's Hospital Boston, USA
Short Talk: Posttranslational Modification of G Protein-coupled Receptor 56 (GPR56) is Essential for Its Function

Thursday, February 16 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys Peak 1-4


Thursday, February 16 | 8:00PM - 11:00PM
Entertainment
Room: Torreys Peak 1-4


Thursday, February 16 | 8:00PM - 11:00PM
Cash Bar
Room: Torreys Peak 1-4


Friday, February 17 | 10:26AM - 10:26AM
Departure


*Session Chair.