Web Desc
Molecular Mechanisms of Cardiac Disease and Regeneration
Organizer(s): Stefanie Dimmeler and Michael D. Schneider
Date: February 19 - 24, 2006
Location: Eldorado Hotel & Spa, Santa Fe, NM, USA
Supported by The Director's Fund
Summary of Meeting:
Inadequate tissue perfusion and defects in the functional activity of cardiac myocytes are the leading cause of death in the Western world. This meeting will provide a comprehensive overview of novel developments in cardiovascular sciences and attempts to enforce interaction between cardiac and vascular areas. The first part of the meeting will focus on the regulation of cardiac development and vessel formation both in embryonic development as well as in the adult organism. Signaling cascades regulating cardiac remodeling and cardiomyopathy will be discussed in the second part. Finally, novel strategies for vessel repair and cardiac regeneration including potential insights from stem-cell-derived cardiomyocytes, and cell-based therapies, will be presented. As aging is a major risk factor for cardiovascular disease a special session will focus on the molecular determinants of aging and its role in cardiac diseases.
Scholarship Deadline: October 19 2005
Discounted Abstract Deadline: October 19 2005
Abstract Deadline: November 10 2005
Discounted Registration Deadline: December 19 2005
We gratefully acknowledge additional support for this conference from:
Boehringer Ingelheim Pharmaceuticals, Inc.Novartis Institutes for BioMedical Research
We gratefully acknowledge the generous grant for this conference provided by:

National Heart, Lung, and Blood Institute (NHLBI)
Grant No. 1R13 HL082183-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Sunday, February 19 | 3:00PM - 7:30PM
Registration
Room: Zia Concourse


Sunday, February 19 | 6:30PM - 7:30PM
Refreshments
Room: Sunset Room


Sunday, February 19 | 7:30PM - 9:30PM
Keynote Session
Room: Anasazi Ballroom

Speaker 3 of 3
Eric N. Olson, University of Texas Southwestern Medical Center, USA
Transcriptional Control of Muscle Cell Hypertrophy and Differentiation

Sunday, February 19 | 7:30PM - 9:30PM
Keynote Session
Room: Anasazi Ballroom

Speaker 2 of 3
Randall T. Moon, University of Washington School of Medicine, USA
Wnt Signaling in Disease and Therapies

Sunday, February 19 | 7:30PM - 9:30PM
Keynote Session
Room: Anasazi Ballroom

Speaker 1 of 3
* Stefanie Dimmeler, University of Frankfurt, Germany

Monday, February 20 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Monday, February 20 | 8:00AM - 11:15AM
Cardiovascular Development: Myogenesis and Morphogenesis
Room: Anasazi Ballroom

Speaker 7 of 7
Kory J. Lavine, Washington University School of Medicine, USA
Short Talk: Hedgehog Signaling Represents a Novel Therapeutic Target for Coronary Neo-Angiogenesis and Is Essential for Coronary Vascular Development

Monday, February 20 | 8:00AM - 11:15AM
Cardiovascular Development: Myogenesis and Morphogenesis
Room: Anasazi Ballroom

Speaker 6 of 7
Ian C. Scott, Hospital for Sick Children, Canada
Short Talk: Novel Role for the Peptide Ligand Apelin in Cardiovascular Development

Monday, February 20 | 8:00AM - 11:15AM
Cardiovascular Development: Myogenesis and Morphogenesis
Room: Anasazi Ballroom

Speaker 5 of 7
Deepak Srivastava, Gladstone Institutes, USA
Role of microRNAs during cardiac progenitor differentiation and cardiogenesis

Monday, February 20 | 8:00AM - 11:15AM
Cardiovascular Development: Myogenesis and Morphogenesis
Room: Anasazi Ballroom

Speaker 4 of 7
Giulio Cossu, Stem Cell Research Institute, Italy
Isolation and Characterization of Post-natal Cardiac Mesoangioblasts with High Cardiac Differentiation Potency

Monday, February 20 | 8:00AM - 11:15AM
Cardiovascular Development: Myogenesis and Morphogenesis
Room: Anasazi Ballroom

Speaker 3 of 7
Brian D. Dynlacht, New York University School of Medicine, USA
Regulatory Networks for Myogenesis

Monday, February 20 | 8:00AM - 11:15AM
Cardiovascular Development: Myogenesis and Morphogenesis
Room: Anasazi Ballroom

Speaker 2 of 7
Mark Mercola, Stanford University, USA
Cardiac Lineage Determination in Embryos and ES Cells

Monday, February 20 | 8:00AM - 11:15AM
Cardiovascular Development: Myogenesis and Morphogenesis
Room: Anasazi Ballroom

Speaker 1 of 7
* Eric N. Olson, University of Texas Southwestern Medical Center, USA

Monday, February 20 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Monday, February 20 | 11:15AM - 1:00PM
Poster Setup
Room: Sunset Room


Monday, February 20 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room


Monday, February 20 | 4:00PM - 5:00PM
Workshop: NHLBI Support: What Every Investigator Needs to Kn
ow
Room: Anasazi Ballroom

Speaker 3 of 3
Sonia I. Skarlatos, NHLBI, National Institutes of Health, USA
NHLBI Research Training and Early Career Development Opportunities

Monday, February 20 | 4:00PM - 5:00PM
Workshop: NHLBI Support: What Every Investigator Needs to Kn
ow
Room: Anasazi Ballroom

Speaker 2 of 3
Stephen C. Mockrin, NHLBI, National Institutes of Health, USA
NHLBI and NIH Programs in Cell-based Therapeutics

Monday, February 20 | 4:00PM - 5:00PM
Workshop: NHLBI Support: What Every Investigator Needs to Kn
ow
Room: Anasazi Ballroom

Speaker 1 of 3
* Elizabeth G. Nabel, Brigham & Womens Hospital, USA
Fostering the Independence of New Investigators: NHLBI initiatives

Monday, February 20 | 4:45PM - 5:00PM
Coffee Available
Room: Zia Concourse


Monday, February 20 | 5:00PM - 7:00PM
Angiogenesis and Vessel Remodeling
Room: Anasazi Ballroom

Speaker 4 of 4
Anne C. Eichmann, Yale University School of Medicine, USA
Neural Guidance Receptors in Angiogenesis

Monday, February 20 | 5:00PM - 7:00PM
Angiogenesis and Vessel Remodeling
Room: Anasazi Ballroom

Speaker 3 of 4
Jonathan A. Epstein, University of Pennsylvania, USA
Class 1 HDAC Function and Cardiac Hypertrophy

Monday, February 20 | 5:00PM - 7:00PM
Angiogenesis and Vessel Remodeling
Room: Anasazi Ballroom

Speaker 2 of 4
Elizabeth G. Nabel, Brigham & Womens Hospital, USA
Vascular Proliferation and Inflammation: Lessons learned from Genetic Diseases

Monday, February 20 | 5:00PM - 7:00PM
Angiogenesis and Vessel Remodeling
Room: Anasazi Ballroom

Speaker 1 of 4
* Didier Stainier, Max Planck Institute for Heart and Lung Research, Germany

Monday, February 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Monday, February 20 | 7:30PM - 10:00PM
Poster Session 1
Room: Sunset Room


Tuesday, February 21 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Tuesday, February 21 | 8:00AM - 11:15AM
Signal Transduction in Hypertrophy and Heart Failure
Room: Anasazi Ballroom

Speaker 1 of 7
* Deepak Srivastava, Gladstone Institutes, USA

Tuesday, February 21 | 8:00AM - 11:15AM
Signal Transduction in Hypertrophy and Heart Failure
Room: Anasazi Ballroom

Speaker 2 of 7
Jeffery D. Molkentin, Cincinnati Children's Hospital Medical Center, USA
ERK1/2 Signaling is not Necessary for Cardiac Hypertrophy in Vivo

Tuesday, February 21 | 8:00AM - 11:15AM
Signal Transduction in Hypertrophy and Heart Failure
Room: Anasazi Ballroom

Speaker 3 of 7
Gabriele Grenningloh, School Polytechanical Federale de Lausanne, France
Protein Kinases in Cardiac Hypertrophy and Remodeling

Tuesday, February 21 | 8:00AM - 11:15AM
Signal Transduction in Hypertrophy and Heart Failure
Room: Anasazi Ballroom

Speaker 4 of 7
Richard N. Kitsis, Albert Einstein College of Medicine, USA
ARC, a Multifunctional Repressor of Multiple Cell Death Pathways

Tuesday, February 21 | 8:00AM - 11:15AM
Signal Transduction in Hypertrophy and Heart Failure
Room: Anasazi Ballroom

Speaker 5 of 7
Seigo Izumo, Takeda Pharmaceutical Company, Japan
Novel Strategies for the Treatment of Heart Failure

Tuesday, February 21 | 8:00AM - 11:15AM
Signal Transduction in Hypertrophy and Heart Failure
Room: Anasazi Ballroom

Speaker 6 of 7
Joost Leenders, Academic Medical Center, Netherlands
Short Talk: Krüppel-Like Factor 15 is a Novel Transcriptional Regulator of Cardiac Hypertrophy Regulated by TGF-Beta

Tuesday, February 21 | 8:00AM - 11:15AM
Signal Transduction in Hypertrophy and Heart Failure
Room: Anasazi Ballroom

Speaker 7 of 7
Thierry Pedrazzini, University of Lausanne Medical School, Switzerland
Short Talk: Notch Pathways Control Cardiogenesis in Undifferentiated Cardiac Precursors and are Crucial for Maintaining Cardiac Integrity in the Adult Heart

Tuesday, February 21 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Tuesday, February 21 | 11:00AM - 1:00PM
Poster Setup
Room: Sunset Room


Tuesday, February 21 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room


Tuesday, February 21 | 4:30PM - 5:00PM
Coffee Available
Room: Zia Concourse


Tuesday, February 21 | 5:00PM - 7:00PM
Mechanisms of Cardiomyopathy and Heart Failure
Room: Anasazi Ballroom

Speaker 1 of 4
* Seigo Izumo, Takeda Pharmaceutical Company, Japan

Tuesday, February 21 | 5:00PM - 7:00PM
Mechanisms of Cardiomyopathy and Heart Failure
Room: Anasazi Ballroom

Speaker 2 of 4
Christine E. Seidman, Harvard Medical School, USA
Genetic Mechanisms of Cardiomyopathy

Tuesday, February 21 | 5:00PM - 7:00PM
Mechanisms of Cardiomyopathy and Heart Failure
Room: Anasazi Ballroom

Speaker 3 of 4
Elizabeth M. McNally, Northwestern University, USA
The Dystrophin Sarcoglycan Complex in Cardiomyopathy

Tuesday, February 21 | 5:00PM - 7:00PM
Mechanisms of Cardiomyopathy and Heart Failure
Room: Anasazi Ballroom

Speaker 4 of 4
Kenneth R. Chien, Karolinska Institutet, Sweden
Islet-1 Cardiovascular Progenitors in Development and Disease

Tuesday, February 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Tuesday, February 21 | 7:30PM - 10:00PM
Poster Session 2
Room: Sunset Room


Wednesday, February 22 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Wednesday, February 22 | 8:00AM - 11:00AM
Stem/Progenitor Cells for Cardiac Repair
Room: Anasazi Ballroom

Speaker 1 of 5
Thomas Eschenhagen, University Medical Center Hamburg-Eppendorf, Germany
Embryonic Stem Cells for Tissue Engineering

Wednesday, February 22 | 8:00AM - 11:00AM
Stem/Progenitor Cells for Cardiac Repair
Room: Anasazi Ballroom

Speaker 2 of 5
Stefanie Dimmeler, University of Frankfurt, Germany
Endothelial Progenitor Cells in Neovascularization and Cardiac Repair

Wednesday, February 22 | 8:00AM - 11:00AM
Stem/Progenitor Cells for Cardiac Repair
Room: Anasazi Ballroom

Speaker 3 of 5
* Douglas W. Losordo, Caladrius Biosciences, Inc., USA
Intramyocardial transplantation of autologous CD 34+ Stem CElls for Intractable Ischemia

Wednesday, February 22 | 8:00AM - 11:00AM
Stem/Progenitor Cells for Cardiac Repair
Room: Anasazi Ballroom

Speaker 4 of 5
Victor J. Dzau, Duke University Medical Center, USA
Paracrine Hypothesis of Stem Cells

Wednesday, February 22 | 8:00AM - 11:00AM
Stem/Progenitor Cells for Cardiac Repair
Room: Anasazi Ballroom

Speaker 5 of 5
Annie Bourdeau, Embassy of Canada, Thailand
Short Talk: Modulation of Bone Marrow-Derived Stem Cell Activity by
TC-PTP


Wednesday, February 22 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Wednesday, February 22 | 11:00AM - 1:00PM
Poster Setup
Room: Sunset Room


Wednesday, February 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room


Wednesday, February 22 | 4:30PM - 5:00PM
Coffee Available
Room: Zia Concourse


Wednesday, February 22 | 5:00PM - 7:00PM
Embryonic and Adult Stem Cell Plasticity
Room: Anasazi Ballroom

Speaker 1 of 4
* Jonathan A. Epstein, University of Pennsylvania, USA

Wednesday, February 22 | 5:00PM - 7:00PM
Embryonic and Adult Stem Cell Plasticity
Room: Anasazi Ballroom

Speaker 2 of 4
Robert J. Schwartz, Texas A&M University, USA
SRF, a Mesoderm Factor Required for the Formation of Embryonic Cardiac and Smooth Muscle Lineages

Wednesday, February 22 | 5:00PM - 7:00PM
Embryonic and Adult Stem Cell Plasticity
Room: Anasazi Ballroom

Speaker 3 of 4
Naohiro Terada, University of Florida, USA
Signals and Scaffolds Controlling the Fate of Embryonic Stem Cell Differentiation

Wednesday, February 22 | 5:00PM - 7:00PM
Embryonic and Adult Stem Cell Plasticity
Room: Anasazi Ballroom

Speaker 4 of 4
Michael D. Schneider, Imperial College London, UK
Cardiopoeisis: Cardiac Myocyte creation by adult and Embryonic Stem Cell

Wednesday, February 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Wednesday, February 22 | 7:30PM - 10:00PM
Poster Session 3
Room: Sunset Room


Thursday, February 23 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Thursday, February 23 | 8:00AM - 11:15AM
Aging and Other Determinants of Cardiac and Vascular Repair
Room: Anasazi Ballroom

Speaker 1 of 6
* Nadia A. Rosenthal, The Jackson Laboratory, USA

Thursday, February 23 | 8:00AM - 11:15AM
Aging and Other Determinants of Cardiac and Vascular Repair
Room: Anasazi Ballroom

Speaker 2 of 6
Margaret A. Goodell, Baylor College of Medicine, USA
Aging in Stem Cells

Thursday, February 23 | 8:00AM - 11:15AM
Aging and Other Determinants of Cardiac and Vascular Repair
Room: Anasazi Ballroom

Speaker 3 of 6
Kenneth Walsh, University of Virginia School of Medicine, USA
Regulation of Physiological and Pathological heart Growth (adipokines and the heart)

Thursday, February 23 | 8:00AM - 11:15AM
Aging and Other Determinants of Cardiac and Vascular Repair
Room: Anasazi Ballroom

Speaker 4 of 6
Andreas M. Zeiher, University Frankfurt, Germany
Clinical Cell Therapy: Determinants of Successful Treatment

Thursday, February 23 | 8:00AM - 11:15AM
Aging and Other Determinants of Cardiac and Vascular Repair
Room: Anasazi Ballroom

Speaker 5 of 6
Rolf Bodmer, Sanford-Burnham Medical Research Institute, USA
The Failing fly Heart f: Drosophila as a Model for Congenital Heart Disease and Aging

Thursday, February 23 | 8:00AM - 11:15AM
Aging and Other Determinants of Cardiac and Vascular Repair
Room: Anasazi Ballroom

Speaker 6 of 6
Didier Stainier, Max Planck Institute for Heart and Lung Research, Germany
Cardiac Development and Function: Forward Genetics and Imaging

Thursday, February 23 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Thursday, February 23 | 4:30PM - 5:00PM
Coffee Available
Room: Zia Concourse


Thursday, February 23 | 5:00PM - 7:00PM
Stem Cell Recruitment and Augmentation
Room: Anasazi Ballroom

Speaker 1 of 4
* Michael D. Schneider, Imperial College London, UK

Thursday, February 23 | 5:00PM - 7:00PM
Stem Cell Recruitment and Augmentation
Room: Anasazi Ballroom

Speaker 2 of 4
Issei Komuro, Tokyo University Graduate School, Japan
Mechanism of Angiogenesis in Ischemic Limb

Thursday, February 23 | 5:00PM - 7:00PM
Stem Cell Recruitment and Augmentation
Room: Anasazi Ballroom

Speaker 3 of 4
Nadia A. Rosenthal, The Jackson Laboratory, USA
Enhancing Regeneration of the Mammalian Heart

Thursday, February 23 | 5:00PM - 7:00PM
Stem Cell Recruitment and Augmentation
Room: Anasazi Ballroom

Speaker 4 of 4
Steven J. Kattman, USA
Short Talk: Specification of Multipotential Cardiovascular Progenitor Cells During ES cell Differentiation

Thursday, February 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Thursday, February 23 | 8:00PM - 11:00PM
Entertainment
Room: Eldorado Court/Sunset Room


Thursday, February 23 | 8:00PM - 11:00PM
Cash Bar
Room: Eldorado Court/Sunset Room


Friday, February 24 | 10:26AM - 10:26AM
Departure


*Session Chair.