Web Desc
Cell Biology of Virus Entry, Replication and Pathogenesis
Organizer(s): Herbert W. Virgin, Robert A. Lamb, Richard W. Compans, Robert W. Doms and Michael B.A. Oldstone
Date: February 24 - March 01, 2006
Location: Eldorado Hotel & Spa, Santa Fe, NM, USA
Supported by The Director's Fund
Summary of Meeting:
The elucidation of the molecular interactions between viral components and cells, and how this determines the outcome of infection is the most exciting area of modern virology. New advances in structural biology, genetics, and molecular virology have speeded the pace of discovery in this area and led to significant insights into virology, immunology and cell biology. The new NIH emphasis on mechanisms of viral infection provides new support and excitement for this already fertile area. The pivotal areas to be covered are (i) the cell biology of virus entry, uncoating, protein traffic, assembly, budding and release, (ii) the defensive mechanisms that cells and organisms use to combat viruses, (iii) strategies of viral immune evasion. These areas impact significantly on fundamental issues in cell biology, cell and species tropism, and pathogenesis of viral diseases. The meeting will once again provide a cross disciplinary forum for discussing novel insights into cell biology of virus infection and the relationship of these findings to pathogenesis and defense. Each session covers a topic rather than a virus family in order to foster discussion across virus family-boundaries. Our topic oriented program has been very successful in the many successful meetings organized since 1988.
Scholarship Deadline: October 25 2005
Discounted Abstract Deadline: October 25 2005
Abstract Deadline: November 17 2005
Discounted Registration Deadline: December 23 2005
We gratefully acknowledge additional support for this conference from:
Novartis Institutes for BioMedical Research
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI066899-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, February 24 | 3:00PM - 7:30PM
Registration
Room: Zia Concourse


Friday, February 24 | 6:30PM - 7:30PM
Refreshments
Room: Sunset Room


Friday, February 24 | 7:30PM - 8:30PM
Keynote Address
Room: Anasazi Ballroom

Speaker 1 of 1
Stephen C. Harrison, Harvard Medical School, USA
Viral Membrane Fusion: The Converging Paradigms

Saturday, February 25 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Saturday, February 25 | 8:00AM - 11:00AM
Viral Receptor Binding and Entry (a)
Room: Anasazi Ballroom

Speaker 1 of 5
* Theodore S. Jardetzky, Stanford University, USA

Saturday, February 25 | 8:00AM - 11:00AM
Viral Receptor Binding and Entry (a)
Room: Anasazi Ballroom

Speaker 2 of 5
Terence S. Dermody, Vanderbilt University School of Medicine, USA
Reovirus Cell Entry and Activation of Innate Immune Response Signaling

Saturday, February 25 | 8:00AM - 11:00AM
Viral Receptor Binding and Entry (a)
Room: Anasazi Ballroom

Speaker 3 of 5
Yusuke Yanagi, Kyushu University, Japan
Measles Virus Receptors: Their Roles in Tropism and Signal Transduction

Saturday, February 25 | 8:00AM - 11:00AM
Viral Receptor Binding and Entry (a)
Room: Anasazi Ballroom

Speaker 4 of 5
John A. T. Young, F.Hoffmann-La Roche Ltd, Switzerland
Early Steps of Retroviral Replication

Saturday, February 25 | 8:00AM - 11:00AM
Viral Receptor Binding and Entry (a)
Room: Anasazi Ballroom

Speaker 5 of 5
Susan R. Ross, University of Pennsylvania, USA
MMTV Interaction with Toll-like Receptors and Other Immunological Signaling Pathways

Saturday, February 25 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Saturday, February 25 | 11:00AM - 1:00PM
Poster Setup
Room: Sunset Room


Saturday, February 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room


Saturday, February 25 | 2:30PM - 4:30PM
Workshop 1: Viral Receptors and Entry

Speaker 1 of 9
* Frederic S. Cohen, Rush Medical College, USA

Saturday, February 25 | 2:30PM - 4:30PM
Workshop 1: Viral Receptors and Entry

Speaker 2 of 9
Christopher Aiken, Vanderbilt University School of Medicine, USA
Inside-Out Regulation of HIV-1 Particle Fusion

Saturday, February 25 | 2:30PM - 4:30PM
Workshop 1: Viral Receptors and Entry

Speaker 3 of 9
Carolyn B. Coyne, University of Pittsburgh, USA
Virus-Induced Abl and Fyn Kinase Signals Permit Coxsackievirus Entry through Epithelial Tight Junctions

Saturday, February 25 | 2:30PM - 4:30PM
Workshop 1: Viral Receptors and Entry

Speaker 4 of 9
Kimberly A. Bishop-Lilly, Naval Medical Research Center, USA
Characterization of the EphrinB2-Binding Site on the Henipavirus G Glycoprotein

Saturday, February 25 | 2:30PM - 4:30PM
Workshop 1: Viral Receptors and Entry

Speaker 5 of 9
Robert A. Davey, Texas Biomedical Research Institute, USA
siRNA Screening for Cellular Factors Required for Infection by Human Respiratory Syncytial Virus Reveals Important Role for Clathrin-Mediated Endocytosis

Saturday, February 25 | 2:30PM - 4:30PM
Workshop 1: Viral Receptors and Entry

Speaker 6 of 9
Karin Stiasny, Medical University of Vienna, Austria
Structural and Functional Dissection of the Flavivirus Membrane Fusion Pathway

Saturday, February 25 | 2:30PM - 4:30PM
Workshop 1: Viral Receptors and Entry

Speaker 7 of 9
Oscar Negrete, Sandia National Labs, USA
EphrinB3 is an Alternate Receptor for Nipah Virus

Saturday, February 25 | 2:30PM - 4:30PM
Workshop 1: Viral Receptors and Entry

Speaker 8 of 9
Lily Y. Lee, Harvard Medical School, USA
Poliovirus Entry and RNA Release: A Multidisciplinary Study

Saturday, February 25 | 2:30PM - 4:30PM
Workshop 1: Viral Receptors and Entry

Speaker 9 of 9
Roy Duncan, Dalhousie University, Canada
Simplified Fusion Machines: The Reovirus Fusion-Associated Small Transmembrane (FAST) Proteins.

Saturday, February 25 | 4:30PM - 5:00PM
Coffee Available
Room: Zia Concourse


Saturday, February 25 | 5:00PM - 7:00PM
Receptor Binding and Entry (b)
Room: Anasazi Ballroom

Speaker 1 of 4
* Robert A. Lamb, Northwestern University, USA

Saturday, February 25 | 5:00PM - 7:00PM
Receptor Binding and Entry (b)
Room: Anasazi Ballroom

Speaker 2 of 4
Theodore S. Jardetzky, Stanford University, USA
Structural Insights into Paramyxovirus Fusion Protein Folding and Function

Saturday, February 25 | 5:00PM - 7:00PM
Receptor Binding and Entry (b)
Room: Anasazi Ballroom

Speaker 3 of 4
Robert P. Blumenthal, NCI, National Institutes of Health, USA
Conformational Changes and Fusion Activity of HIV Envelope Glycoproteins

Saturday, February 25 | 5:00PM - 7:00PM
Receptor Binding and Entry (b)
Room: Anasazi Ballroom

Speaker 4 of 4
Richard W. Compans, Emory University, Rollins Research Center, USA
Specific Inhibition of Paramyxovirus F-Mediated Membrane Fusion

Saturday, February 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Saturday, February 25 | 7:30PM - 10:00PM
Poster Session 1
Room: Sunset Room


Sunday, February 26 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Sunday, February 26 | 8:00AM - 11:00AM
Viral Movement and Trafficking
Room: Anasazi Ballroom

Speaker 1 of 5
* Robert W. Doms, University of Pennsylvania School of Medicine, USA

Sunday, February 26 | 8:00AM - 11:00AM
Viral Movement and Trafficking
Room: Anasazi Ballroom

Speaker 2 of 5
Ari Helenius, ETH Zurich, Switzerland
How Viruses Enter Animal Cells

Sunday, February 26 | 8:00AM - 11:00AM
Viral Movement and Trafficking
Room: Anasazi Ballroom

Speaker 3 of 5
Thomas J. Hope, Northwestern University, USA
Virus Interactions with Dendritic Cells: Moving to the Synapse

Sunday, February 26 | 8:00AM - 11:00AM
Viral Movement and Trafficking
Room: Anasazi Ballroom

Speaker 4 of 5
Geoffrey L. Smith, University of Cambridge, UK
Ligand-Induced and Non-Fusogenic Dissolution of a Virus Membrane

Sunday, February 26 | 8:00AM - 11:00AM
Viral Movement and Trafficking
Room: Anasazi Ballroom

Speaker 5 of 5
Xiaowei Zhuang, Harvard University, USA
Entry and Trafficking of Influenza Viruses by Single-Virus Tracking

Sunday, February 26 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Sunday, February 26 | 11:00AM - 1:00PM
Poster Setup
Room: Sunset Room


Sunday, February 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room


Sunday, February 26 | 2:30PM - 4:30PM
Workshop 2: Immunity, Antivirals and Vaccines

Speaker 1 of 9
* Mary K. Estes, Baylor College of Medicine, USA

Sunday, February 26 | 2:30PM - 4:30PM
Workshop 2: Immunity, Antivirals and Vaccines

Speaker 2 of 9
Sheri L. Hanna, University of Pennsylvania, USA
Contribution of WNV Envelope N-linked Glycosylation to Assembly, Infectivity and Tropism

Sunday, February 26 | 2:30PM - 4:30PM
Workshop 2: Immunity, Antivirals and Vaccines

Speaker 3 of 9
Grant E. Nybakken, Washington University, USA
Mechanistic Correlates of Antibody-Mediated Protection against West Nile Virus Infection

Sunday, February 26 | 2:30PM - 4:30PM
Workshop 2: Immunity, Antivirals and Vaccines

Speaker 4 of 9
Christian D.S. Nelson, Cornell University, USA
Antibody Neutralization Mechanisms: Different Responses to Antibody Binding at the Same Site in a Virus Capsid

Sunday, February 26 | 2:30PM - 4:30PM
Workshop 2: Immunity, Antivirals and Vaccines

Speaker 5 of 9
Rebecca K. Holmes, King's College London, UK
Unravelling the Importance of Cytidine Deamination for the Anti-Viral Activity of APOBEC3G and APOBEC3F

Sunday, February 26 | 2:30PM - 4:30PM
Workshop 2: Immunity, Antivirals and Vaccines

Speaker 6 of 9
Dapeng Zhou, MD Anderson Cancer Center, USA
A Natural Glycolipid Ligand of NKT Cells: Implications for Anti-Viral Immunity

Sunday, February 26 | 2:30PM - 4:30PM
Workshop 2: Immunity, Antivirals and Vaccines

Speaker 7 of 9
Byeongwoon Song, Emory University, USA
TRIM5alpha: Retroviral Restriction and Subcellular Localization

Sunday, February 26 | 2:30PM - 4:30PM
Workshop 2: Immunity, Antivirals and Vaccines

Speaker 8 of 9
Xiuyan Wang, Yale University School of Medicine, USA
A Novel Antiviral Mechanism Mediated by the Interferon-Inducible Protein Viperin

Sunday, February 26 | 2:30PM - 4:30PM
Workshop 2: Immunity, Antivirals and Vaccines

Speaker 9 of 9
Michael S. Kay, University of Utah School of Medicine, USA
Steric Accessibility of the HIV-1 gp41 N-Trimer Region

Sunday, February 26 | 4:30PM - 5:00PM
Coffee Available
Room: Zia Concourse


Sunday, February 26 | 5:00PM - 7:00PM
Virus Assembly and Release
Room: Anasazi Ballroom

Speaker 1 of 4
* Richard W. Compans, Emory University, Rollins Research Center, USA

Sunday, February 26 | 5:00PM - 7:00PM
Virus Assembly and Release
Room: Anasazi Ballroom

Speaker 2 of 4
Eric Hunter, Emory University, USA
Cell Biology of Retroviral Assembly and Release

Sunday, February 26 | 5:00PM - 7:00PM
Virus Assembly and Release
Room: Anasazi Ballroom

Speaker 3 of 4
Robert A. Lamb, Northwestern University, USA
Influenza Virus Assembly at the Viral Budozone

Sunday, February 26 | 5:00PM - 7:00PM
Virus Assembly and Release
Room: Anasazi Ballroom

Speaker 4 of 4
Wesley I. Sundquist, University of Utah School of Medicine, USA
The Biochemistry of HIV Release

Sunday, February 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Sunday, February 26 | 7:30PM - 10:00PM
Poster Session 2
Room: Sunset Room


Monday, February 27 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Monday, February 27 | 8:00AM - 11:00AM
Cellular Genes and Virus Infection
Room: Anasazi Ballroom

Speaker 1 of 5
* Otto Haller, University of Freiburg, Germany

Monday, February 27 | 8:00AM - 11:00AM
Cellular Genes and Virus Infection
Room: Anasazi Ballroom

Speaker 2 of 5
Jeff Bergelson, University of Pennsylvania, USA
Kinase Signals Permit Coxsackievirus Entry through Epithelial Type Junction

Monday, February 27 | 8:00AM - 11:00AM
Cellular Genes and Virus Infection
Room: Anasazi Ballroom

Speaker 3 of 5
Stephen P. Goff, Columbia University, USA
Host Factors Involved in Retroviral Replication

Monday, February 27 | 8:00AM - 11:00AM
Cellular Genes and Virus Infection
Room: Anasazi Ballroom

Speaker 4 of 5
Beth Levine, University of Texas Southwestern Medical Center, USA
Autophagy in Innate Antiviral Immunity

Monday, February 27 | 8:00AM - 11:00AM
Cellular Genes and Virus Infection
Room: Anasazi Ballroom

Speaker 5 of 5
Daved Fremont, Washington University School of Medicine, USA
Structural Mechanisms of Viral Immune Evasion

Monday, February 27 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Monday, February 27 | 11:00AM - 1:00PM
Poster Setup
Room: Sunset Room


Monday, February 27 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room


Monday, February 27 | 2:30PM - 4:30PM
Workshop 3: Intracellular Movement, Trafficking and Assembly
of Viruses

Speaker 1 of 9
* Jeff Bergelson, University of Pennsylvania, USA

Monday, February 27 | 2:30PM - 4:30PM
Workshop 3: Intracellular Movement, Trafficking and Assembly
of Viruses

Speaker 2 of 9
Sara R. Cherry, University of Pennsylvania, USA
COPI Activity Coupled with Fatty Acid Biosynthesis is Required for Viral Replication

Monday, February 27 | 2:30PM - 4:30PM
Workshop 3: Intracellular Movement, Trafficking and Assembly
of Viruses

Speaker 3 of 9
Susana Guix, Baylor College of Medicine, USA
Studies of Norwalk Virus RNA Encapsidation

Monday, February 27 | 2:30PM - 4:30PM
Workshop 3: Intracellular Movement, Trafficking and Assembly
of Viruses

Speaker 4 of 9
Christopher T. Cornell, The Scripps Research Institute, USA
Inhibition of Host Protein Secretion by Coxsackievirus b3 (CVB3): Multiple Gene Products Target a Common Organelle

Monday, February 27 | 2:30PM - 4:30PM
Workshop 3: Intracellular Movement, Trafficking and Assembly
of Viruses

Speaker 5 of 9
Benjamin J. Chen, Northwestern University, USA
Influenza Virus Hemagglutinin (H3) Requires Palmitoylation of its Cytoplasmic Tail for Assembly: M1 Proteins of Two Subtypes Differ in their Ability to Support Assembly

Monday, February 27 | 2:30PM - 4:30PM
Workshop 3: Intracellular Movement, Trafficking and Assembly
of Viruses

Speaker 6 of 9
Markus Thali, University of Vermont, USA
Tetraspanin-Enriched Microdomains (TEMs) Function as Gateways for HIV-1

Monday, February 27 | 2:30PM - 4:30PM
Workshop 3: Intracellular Movement, Trafficking and Assembly
of Viruses

Speaker 7 of 9
Glenn F. Rall, Fox Chase Cancer Center, USA
Neurokinin-1 Interacts with the Measles Virus Fusion Protein to Facilitate Trans-Synaptic Spread in Neurons

Monday, February 27 | 2:30PM - 4:30PM
Workshop 3: Intracellular Movement, Trafficking and Assembly
of Viruses

Speaker 8 of 9
David C. Johnson, Oregon Health & Science University, USA
Spread of Herpes Simplex Virus in Epithelial and Neuronal Tissues is Promoted by Membrane Proteins gE/gI and US9 which Sort Virions to Cell Junctions

Monday, February 27 | 2:30PM - 4:30PM
Workshop 3: Intracellular Movement, Trafficking and Assembly
of Viruses

Speaker 9 of 9
Laura Burleigh, Institut Pasteur, France
Long–Term Transfer of HIV from Immature Dendritic Cells to T Cells Occurs Exclusively through DC-SIGN-Mediated Cis Infection and not Intracellular Storage of Incoming Virus

Monday, February 27 | 4:30PM - 5:00PM
Coffee Available
Room: Zia Concourse


Monday, February 27 | 5:00PM - 7:00PM
Viruses and Immunity
Room: Anasazi Ballroom

Speaker 1 of 4
* Herbert (Skip) W. Virgin, Vir Biotechnology, USA

Monday, February 27 | 5:00PM - 7:00PM
Viruses and Immunity
Room: Anasazi Ballroom

Speaker 2 of 4
Elina I. Zuniga, University of California, San Diego, USA
Viral Deregulation of Innate Immunity

Monday, February 27 | 5:00PM - 7:00PM
Viruses and Immunity
Room: Anasazi Ballroom

Speaker 3 of 4
Ira Mellman, Genentech, Inc., USA
Dendritic Cells and Virus Infection

Monday, February 27 | 5:00PM - 7:00PM
Viruses and Immunity
Room: Anasazi Ballroom

Speaker 4 of 4
Raymond M. Welsh, University of Massachusetts Medical School, USA
Privacy of T Cell-Dependent Heterologous Antiviral Immunity

Monday, February 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Monday, February 27 | 7:30PM - 10:00PM
Poster Session 3
Room: Sunset Room


Tuesday, February 28 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Tuesday, February 28 | 8:00AM - 11:00AM
Control of Infection and Viral Vaccines
Room: Anasazi Ballroom

Speaker 1 of 5
* Ann M. Arvin, Stanford University, USA

Tuesday, February 28 | 8:00AM - 11:00AM
Control of Infection and Viral Vaccines
Room: Anasazi Ballroom

Speaker 2 of 5
Rafi Ahmed, Emory University School of Medicine, USA
Mechanisms of T Cell Memory in Antiviral Immunity

Tuesday, February 28 | 8:00AM - 11:00AM
Control of Infection and Viral Vaccines
Room: Anasazi Ballroom

Speaker 3 of 5
Robert W. Doms, University of Pennsylvania School of Medicine, USA

Tuesday, February 28 | 8:00AM - 11:00AM
Control of Infection and Viral Vaccines
Room: Anasazi Ballroom

Speaker 4 of 5
Nancy J. Sullivan, NIAID, National Institutes of Health, USA
Ebola Virus Immunity

Tuesday, February 28 | 8:00AM - 11:00AM
Control of Infection and Viral Vaccines
Room: Anasazi Ballroom

Speaker 5 of 5
Curt M. Horvath, Northwestern University, USA
Activation and Inhibition of Cellular Interferon Responses and Innate Antiviral Immunity

Tuesday, February 28 | 9:20AM - 9:40AM
Coffee Break
Room: Zia Concourse


Tuesday, February 28 | 4:30PM - 5:00PM
Coffee Available
Room: Zia Concourse


Tuesday, February 28 | 5:00PM - 7:00PM
Viral Disease and Pathogenesis
Room: Anasazi Ballroom

Speaker 1 of 4
* Rafi Ahmed, Emory University School of Medicine, USA

Tuesday, February 28 | 5:00PM - 7:00PM
Viral Disease and Pathogenesis
Room: Anasazi Ballroom

Speaker 2 of 4
Francis V. Chisari, The Scripps Research Institute, USA
Robust Hepatitis C Virus Infection in Vitro: Coevolution of Virus and Host

Tuesday, February 28 | 5:00PM - 7:00PM
Viral Disease and Pathogenesis
Room: Anasazi Ballroom

Speaker 3 of 4
Herbert (Skip) W. Virgin, Vir Biotechnology, USA
Replication of, and Resistance to, a Novel Norovirus

Tuesday, February 28 | 5:00PM - 7:00PM
Viral Disease and Pathogenesis
Room: Anasazi Ballroom

Speaker 4 of 4
Ann M. Arvin, Stanford University, USA
New Insights into Varicella-Zoster Virus Pathogenesis

Tuesday, February 28 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Tuesday, February 28 | 8:00PM - 11:00PM
Entertainment
Room: Eldorado Court/Sunset Room


Tuesday, February 28 | 8:00PM - 11:00PM
Cash Bar
Room: Eldorado Court/Sunset Room


Wednesday, March 01 | 10:26AM - 10:26AM
Departure


*Session Chair.