Web Desc
Malaria: Functional Genomics to Biology to Medicine
Organizer(s): Dyann F. Wirth, Carole A. Long and Alan Cowman
Date: February 28 - March 05, 2006
Location: Sagebrush Inn & Suites, Taos, NM, USA
Part of the Global Health Series, Supported by the Bill & Melinda Gates Foundation
For important information on the coronavirus, please click here
Summary of Meeting:
Malaria remains a major world health problem and with increasing resistance to antimalarial drugs, its health impact is increasing. New knowledge stimulated by sequencing of the genomes of both the parasite P. falciparum, P. vivax and others and the major mosquito vector, Anopheles gambiae, has led to an explosion in scientific activity, ranging from the elucidation of basic biological mechanisms to new insights into disease pathogenesis and transmission. This meeting seeks to bring together a diverse group of scientists working on different aspects of the biology and the disease in order to compare the latest discoveries and insights. The pace of scientific discovery in this area is accelerating and this meeting will seek to provide an overview of the most significant developments and serve to identify opportunities for new research areas and collaborations. Of particular importance in this field is the interplay between basic scientific discovery and the clinical and epidemiological discoveries in the natural population and this meeting seeks to identify these key interfaces. The specific aims of the meeting are the following: 1) Provide a forum for the presentation and discussion of latest and most significant developments in malaria biology 2) Provide an opportunity for exchange of ideas between scientists coming from different disciplines and for the potential development of new collaborations 3) Provide an enriched environment for trainees (graduate students, postdoctoral fellows) to interact with key researchers in this field 4) Provide an opportunity to identify the best strategies for the translation of basic knowledge into new interventions.
Scholarship Deadline: October 27 2005
Discounted Abstract Deadline: October 27 2005
Abstract Deadline: November 21 2005
Discounted Registration Deadline: December 28 2005
We gratefully acknowledge additional support for this conference from:
Bill & Melinda Gates FoundationBurroughs Wellcome Fund
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

GlaxoSmithKline

GlaxoSmithKline Biologicals
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13 AI068319-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, February 28 | 3:00PM - 7:30PM
Registration
Room: Chamisa Lobby


Tuesday, February 28 | 6:30PM - 7:30PM
Refreshments
Room: Chamisa Lobby


Tuesday, February 28 | 7:30PM - 8:30PM
Keynote Address
Room: Chamisa Ballroom 1

Speaker 1 of 1
Regina N. Rabinovich, ISGlobal, Spain / Harvard T.H. Chan School of Public Health, USA, Spain

Wednesday, March 01 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Wednesday, March 01 | 8:00AM - 11:00AM
Systems Biology of Plasmodium
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Dyann F. Wirth, Harvard School of Public Health, USA

Wednesday, March 01 | 8:00AM - 11:00AM
Systems Biology of Plasmodium
Room: Chamisa Ballroom 1

Speaker 2 of 5
Kirk W. Deitsch, Cornell University, USA
Promoter-Promoter Interactions and var Gene Silencing

Wednesday, March 01 | 8:00AM - 11:00AM
Systems Biology of Plasmodium
Room: Chamisa Ballroom 1

Speaker 3 of 5
Artur Scherf, Institut Pasteur, FRANCE
Antigenic Variation in P. falciparum: 'Mind Games' or 'Path for New Therapies'

Wednesday, March 01 | 8:00AM - 11:00AM
Systems Biology of Plasmodium
Room: Chamisa Ballroom 1

Speaker 4 of 5
Alan F. Cowman, Walter and Eliza Hall Institute of Medical Research, Australia
Molecular Systems for Erythrocyte Remodelling and Trafficking in Plasmodium

Wednesday, March 01 | 8:00AM - 11:00AM
Systems Biology of Plasmodium
Room: Chamisa Ballroom 1

Speaker 5 of 5
L. David Sibley, Washington University School of Medicine, USA
Actin-based Motility and Cell Invasion by Apicomplexan Parasites.

Wednesday, March 01 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Wednesday, March 01 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Wednesday, March 01 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Wednesday, March 01 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Wednesday, March 01 | 5:00PM - 7:15PM
From Genomes to Biology
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Alan F. Cowman, Walter and Eliza Hall Institute of Medical Research, Australia

Wednesday, March 01 | 5:00PM - 7:15PM
From Genomes to Biology
Room: Chamisa Ballroom 1

Speaker 2 of 6
Elizabeth A. Winzeler, University of California, San Diego, USA
Molecular Networks in Malaria

Wednesday, March 01 | 5:00PM - 7:15PM
From Genomes to Biology
Room: Chamisa Ballroom 1

Speaker 3 of 6
Jane M. Carlton, Institute for Genomic Research, USA
Comparative Genomics: Insights into Plasmodium Biology

Wednesday, March 01 | 5:00PM - 7:15PM
From Genomes to Biology
Room: Chamisa Ballroom 1

Speaker 4 of 6
David Garboczi, NIAID, National Institutes of Health, USA
Short Talk: Structures of the Essential Mosquito-Stage Protein P25 and its Complex with a Transmission-Blocking Antibody

Wednesday, March 01 | 5:00PM - 7:15PM
From Genomes to Biology
Room: Chamisa Ballroom 1

Speaker 5 of 6
Niraj Tolia, Washington University School of Medicine, USA
Short Talk: Structural Basis for the EBA-175 Erythrocyte Invasion Pathway of the Malaria Parasite Plasmodium Falciparum

Wednesday, March 01 | 5:00PM - 7:15PM
From Genomes to Biology
Room: Chamisa Ballroom 1

Speaker 6 of 6
John H. Adams, University of South Florida College of Public Health, COPH, USA
Emergent Genome Wide Genetic Screens for Virulence Determinants in P. falciparum

Wednesday, March 01 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Wednesday, March 01 | 7:30PM - 10:00PM
Poster Session 1
Room: Chamisa Ballroom 2


Thursday, March 02 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Thursday, March 02 | 8:00AM - 11:15AM
Genetic Diversity in the Parasite and the Host
Room: Chamisa Ballroom 1

Speaker 1 of 7
* David J. Conway, London School of Hygiene and Tropical Medicine, UK

Thursday, March 02 | 8:00AM - 11:15AM
Genetic Diversity in the Parasite and the Host
Room: Chamisa Ballroom 1

Speaker 2 of 7
Dyann F. Wirth, Harvard School of Public Health, USA
A Haplotype Map for Plasmodium falciparum

Thursday, March 02 | 8:00AM - 11:15AM
Genetic Diversity in the Parasite and the Host
Room: Chamisa Ballroom 1

Speaker 3 of 7
Chetan E. Chitnis, International Centre for Genetic Engineering and Biotechnology, India
Targeting Malaria Proteins Involved in Erythrocyte Invasion

Thursday, March 02 | 8:00AM - 11:15AM
Genetic Diversity in the Parasite and the Host
Room: Chamisa Ballroom 1

Speaker 4 of 7
Xin-zhuan Su, NIAID, National Institutes of Health, USA
Population Structure and Evolution in P. falciparum

Thursday, March 02 | 8:00AM - 11:15AM
Genetic Diversity in the Parasite and the Host
Room: Chamisa Ballroom 1

Speaker 5 of 7
Lea Barfod, University of Oxford, UK
Short Talk: The Human IgG Response to Pregnancy-Associated Malaria is VAR2CSA Specific

Thursday, March 02 | 8:00AM - 11:15AM
Genetic Diversity in the Parasite and the Host
Room: Chamisa Ballroom 1

Speaker 6 of 7
Patrick E. Duffy, NIAID, National Institutes for Health, USA
Malaria Pathogenesis and the Parasite Genome

Thursday, March 02 | 8:00AM - 11:15AM
Genetic Diversity in the Parasite and the Host
Room: Chamisa Ballroom 1

Speaker 7 of 7
David A. Fidock, Columbia University Medical Center, USA
Short Talk: Rapid and Efficient Site-Specific Integration System in Plasmodium Falciparum Mediated by Mycobacteriophage Bxb1 Integrase

Thursday, March 02 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Thursday, March 02 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Thursday, March 02 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Thursday, March 02 | 2:30PM - 4:30PM
Workshop: Translation of Basic Science: The Gap from Knowled
ge to Practical Application
Room: Chamisa Ballroom 1

Speaker 1 of 8
Filip Dubovsky, Malaria Vaccine Initiative, PATH, USA

Thursday, March 02 | 2:30PM - 4:30PM
Workshop: Translation of Basic Science: The Gap from Knowled
ge to Practical Application
Room: Chamisa Ballroom 1

Speaker 2 of 8
J. Carl Craft, Medicines for Malaria Venture, Switzerland

Thursday, March 02 | 2:30PM - 4:30PM
Workshop: Translation of Basic Science: The Gap from Knowled
ge to Practical Application
Room: Chamisa Ballroom 1

Speaker 3 of 8
Lee Fenton Hall, NIAID, National Institutes of Health, USA

Thursday, March 02 | 2:30PM - 4:30PM
Workshop: Translation of Basic Science: The Gap from Knowled
ge to Practical Application
Room: Chamisa Ballroom 1

Speaker 4 of 8
Val Snewin, Wellcome Trust, UK

Thursday, March 02 | 2:30PM - 4:30PM
Workshop: Translation of Basic Science: The Gap from Knowled
ge to Practical Application
Room: Chamisa Ballroom 1

Speaker 5 of 8
Solomon O. Nwaka, World Health Organization, Switzerland

Thursday, March 02 | 2:30PM - 4:30PM
Workshop: Translation of Basic Science: The Gap from Knowled
ge to Practical Application
Room: Chamisa Ballroom 1

Speaker 6 of 8
Victoria McGovern, Burroughs-Wellcome Fund, USA

Thursday, March 02 | 2:30PM - 4:30PM
Workshop: Translation of Basic Science: The Gap from Knowled
ge to Practical Application
Room: Chamisa Ballroom 1

Speaker 7 of 8
Daniel J. Carucci, Foundation for the National Institutes of Health, USA

Thursday, March 02 | 2:30PM - 4:30PM
Workshop: Translation of Basic Science: The Gap from Knowled
ge to Practical Application
Room: Chamisa Ballroom 1

Speaker 8 of 8
Douglas Andrew Holtzman, Palindrome BioConsulting, USA

Thursday, March 02 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Thursday, March 02 | 5:00PM - 7:15PM
Natural Populations: Insights into Parasite Biology
Room: Chamisa Ballroom 1

Speaker 1 of 5
* Elizabeth A. Winzeler, University of California, San Diego, USA

Thursday, March 02 | 5:00PM - 7:15PM
Natural Populations: Insights into Parasite Biology
Room: Chamisa Ballroom 1

Speaker 2 of 5
Eleanor M. Riley, Roslin Institute, UK
Balancing Immunity and Immunopathology in Malaria Infections

Thursday, March 02 | 5:00PM - 7:15PM
Natural Populations: Insights into Parasite Biology
Room: Chamisa Ballroom 1

Speaker 3 of 5
David J. Conway, London School of Hygiene and Tropical Medicine, UK
Virulence and Genetic Diversity

Thursday, March 02 | 5:00PM - 7:15PM
Natural Populations: Insights into Parasite Biology
Room: Chamisa Ballroom 1

Speaker 4 of 5
Abdoulaye Djimde, University of Science, Techniques and Technologies, Mali
A Holistic Approach to Antimalarial Drug Resistance

Thursday, March 02 | 5:00PM - 7:15PM
Natural Populations: Insights into Parasite Biology
Room: Chamisa Ballroom 1

Speaker 5 of 5
Daniel C. Jeffares, Wellcome Trust Sanger Institute, UK
Short Talk: A Genome-Wide Analysis of Genetic Diversity and Evolution between three P. falciparum Isolates and P. reichenowi

Thursday, March 02 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Thursday, March 02 | 7:30PM - 10:00PM
Poster Session 2
Room: Chamisa Ballroom 2


Friday, March 03 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Friday, March 03 | 8:00AM - 11:15AM
Host Immune Response to Malaria: Biology and Genetics
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Brendan S. Crabb, Burnet Institute, Australia

Friday, March 03 | 8:00AM - 11:15AM
Host Immune Response to Malaria: Biology and Genetics
Room: Chamisa Ballroom 1

Speaker 2 of 7
Carole A. Long, National Institutes of Health, USA
Evaluation of AMA-1 and MSP-1 Vaccine Candidates

Friday, March 03 | 8:00AM - 11:15AM
Host Immune Response to Malaria: Biology and Genetics
Room: Chamisa Ballroom 1

Speaker 3 of 7
Ann M. Moormann, University of Massachusetts Medical School, USA
Short Talk: Children Living in a Malaria Holoendemic Region of Western Kenya with Both IFN-gamma Responses and Antibodies to MSP-1 Showed the Greatest Protection from Plasmodium Falciparum Infection

Friday, March 03 | 8:00AM - 11:15AM
Host Immune Response to Malaria: Biology and Genetics
Room: Chamisa Ballroom 1

Speaker 4 of 7
Fidel P. Zavala, Johns Hopkins Bloomberg School of Public Health, USA
CD8+ T Cells and Liver Stages

Friday, March 03 | 8:00AM - 11:15AM
Host Immune Response to Malaria: Biology and Genetics
Room: Chamisa Ballroom 1

Speaker 5 of 7
William Ballou, GlaxoSmithKline, USA
Prospects for a Malaria Vaccine: Recent Results with RTS,S

Friday, March 03 | 8:00AM - 11:15AM
Host Immune Response to Malaria: Biology and Genetics
Room: Chamisa Ballroom 1

Speaker 6 of 7
William R. Heath, University of Melbourne, Australia
Dissecting the Initiation of Immunity to P.berghei

Friday, March 03 | 8:00AM - 11:15AM
Host Immune Response to Malaria: Biology and Genetics
Room: Chamisa Ballroom 1

Speaker 7 of 7
Mats Wahlgren, Karolinska Institutet, Sweden
Short Talk: Identification of SURFIN by Surfeomics

Friday, March 03 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Friday, March 03 | 11:00AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 2


Friday, March 03 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 2


Friday, March 03 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Friday, March 03 | 5:00PM - 7:00PM
Mosquito-Parasite Interactions: Biology and Genetics
Room: Chamisa Ballroom 1

Speaker 1 of 4
* Carole A. Long, National Institutes of Health, USA

Friday, March 03 | 5:00PM - 7:00PM
Mosquito-Parasite Interactions: Biology and Genetics
Room: Chamisa Ballroom 1

Speaker 2 of 4
Fotis C. Kafatos, Imperial College London, UK
Malaria: A Disease that Requires 3 Organisms

Friday, March 03 | 5:00PM - 7:00PM
Mosquito-Parasite Interactions: Biology and Genetics
Room: Chamisa Ballroom 1

Speaker 3 of 4
Prakash Srinivasan, Johns Hopkins Bloomberg School of Public Health, USA
Short Talk: PbCAP1 is Essential for Plasmodium Oocyst Development

Friday, March 03 | 5:00PM - 7:00PM
Mosquito-Parasite Interactions: Biology and Genetics
Room: Chamisa Ballroom 1

Speaker 4 of 4
Andrew P. Waters, University of Glasgow, UK
Gametocytes in the Starting Blocks: The Control of RNA Homeostasis

Friday, March 03 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Friday, March 03 | 7:30PM - 10:00PM
Poster Session 3
Room: Chamisa Ballroom 2


Saturday, March 04 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Saturday, March 04 | 8:00AM - 11:15AM
From Biology to Drugs and Vaccines
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Eleanor M. Riley, Roslin Institute, UK

Saturday, March 04 | 8:00AM - 11:15AM
From Biology to Drugs and Vaccines
Room: Chamisa Ballroom 1

Speaker 2 of 7
Pradipsinh K. Rathod, University of Washington, USA
Biochemical Correlates of Drug Sensitivity:
From Target Proteins to Cell Populations


Saturday, March 04 | 8:00AM - 11:15AM
From Biology to Drugs and Vaccines
Room: Chamisa Ballroom 1

Speaker 3 of 7
Jose F. Garcia-Bustos, GlaxoSmithKline, Spain
4-(1H)Pyridones: Novel Inhibitors for a Proven Target

Saturday, March 04 | 8:00AM - 11:15AM
From Biology to Drugs and Vaccines
Room: Chamisa Ballroom 1

Speaker 4 of 7
Yongyuth Yuthavong, BIOTEC, Thailand National Science and Technology Development Agency, Thailand
Structural Biology and Drug Design: Dihydrofolate Reductases as Targets for Antiprotozoal Drugs

Saturday, March 04 | 8:00AM - 11:15AM
From Biology to Drugs and Vaccines
Room: Chamisa Ballroom 1

Speaker 5 of 7
Tamara K. Berthoud, Oxford University, UK
Short Talk: Measurement of Immunogenicity Following Malaria Vaccination in Humans

Saturday, March 04 | 8:00AM - 11:15AM
From Biology to Drugs and Vaccines
Room: Chamisa Ballroom 1

Speaker 6 of 7
Ana Júlia Afonso, Instituto de Higiene e Medicina Tropical, Portugal
Short Talk: Molecular and Genetic Analysis Of Malaria Parasites Displaying Stable Resistance to Artemisinin and Artesunate

Saturday, March 04 | 8:00AM - 11:15AM
From Biology to Drugs and Vaccines
Room: Chamisa Ballroom 1

Speaker 7 of 7
Stephen A. Ward, Liverpool School of Tropical Medicine, UK
Antimalarial Chemotherapy: Exploiting the Parasite's Achilles Heel

Saturday, March 04 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Saturday, March 04 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Saturday, March 04 | 5:00PM - 7:00PM
New Frontiers in Host-Parasite Interactions
Room: Chamisa Ballroom 1

Speaker 1 of 4
* Jane M. Carlton, Institute for Genomic Research, USA

Saturday, March 04 | 5:00PM - 7:00PM
New Frontiers in Host-Parasite Interactions
Room: Chamisa Ballroom 1

Speaker 2 of 4
Stefan Kappe, Seattle BioMed, USA
Liver Stage Development and Host Interactions

Saturday, March 04 | 5:00PM - 7:00PM
New Frontiers in Host-Parasite Interactions
Room: Chamisa Ballroom 1

Speaker 3 of 4
Cristina Dias Rodrigues, Instituto de Medicina Molecular, Portugal
Short Talk: Identification of host factors required for liver stage infection by Plasmodium using RNA interference


Saturday, March 04 | 5:00PM - 7:00PM
New Frontiers in Host-Parasite Interactions
Room: Chamisa Ballroom 1

Speaker 4 of 4
Brendan S. Crabb, Burnet Institute, Australia
New Insights into Merozoite Surface Antigens

Saturday, March 04 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Chamisa Ballroom 2


Saturday, March 04 | 8:00PM - 11:00PM
Entertainment
Room: Chamisa Ballroom 2


Saturday, March 04 | 8:00PM - 11:00PM
Cash Bar
Room: Chamisa Ballroom 2


Sunday, March 05 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.