Past Meeting | Keystone Symposia

This meeting took place in the past. Here is a list of meetings that are related:
New Paradigms in Cancer Therapeutics (2010Z1)
Molecular Targets for Cancer (2007X3)

Web Desc
Molecular Targets for Cancer Prevention Organizer(s): Scott M. Lippman, Nancy H. Colburn and Andrew J. Dannenberg Date: March 06 - 10, 2006 Location: Granlibakken Tahoe, Tahoe City, CA, USA Supported by The Director's Fund Summary of Meeting: The most promising directions in cancer prevention lie in the early identification of high-risk individuals and the development of targeted interventions to prevent or delay carcinogenesis. A revolution in molecular studies and drug development has blurred the distinction between malignancy and pre-malignancy and between cancer therapy and prevention. Molecular targeted agents have produced major clinical advances in randomized controlled cancer prevention trials. Inflammation and obesity have emerged as important risk factors and provide new molecular targets for prevention such as HIF-1 and IGF-1. Molecular studies of fatty acid metabolism and stromal-epithelial interactions in carcinogenesis have identified targets such as cyclooxygenases, lipoxygenases, ECM proteases, and TGF-beta. Translation joins transcription as a new gene-regulation target for interventions; translationally regulated targets include c-myc and ODC. Imaging and proteomics have revealed new biomarkers that enable the early detection of cancer and enable more effective monitoring of drug effects in cancer prevention trials. Scholarship Deadline: November 7 2005 Discounted Abstract Deadline: November 7 2005 Abstract Deadline: November 29 2005 Discounted Registration Deadline: January 6 2006 We gratefully acknowledge additional support for this conference from: We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising: Click here to view more of these organizations Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds: Click here to view more of these organizations

Web Desc

Molecular Targets for Cancer Prevention

Organizer(s): Scott M. Lippman, Nancy H. Colburn and Andrew J. Dannenberg

Date: March 06 - 10, 2006
Location: Granlibakken Tahoe, Tahoe City, CA, USA

Supported by The Director's Fund

Summary of Meeting:

The most promising directions in cancer prevention lie in the early identification of high-risk individuals and the development of targeted interventions to prevent or delay carcinogenesis. A revolution in molecular studies and drug development has blurred the distinction between malignancy and pre-malignancy and between cancer therapy and prevention. Molecular targeted agents have produced major clinical advances in randomized controlled cancer prevention trials. Inflammation and obesity have emerged as important risk factors and provide new molecular targets for prevention such as HIF-1 and IGF-1. Molecular studies of fatty acid metabolism and stromal-epithelial interactions in carcinogenesis have identified targets such as cyclooxygenases, lipoxygenases, ECM proteases, and TGF-beta. Translation joins transcription as a new gene-regulation target for interventions; translationally regulated targets include c-myc and ODC. Imaging and proteomics have revealed new biomarkers that enable the early detection of cancer and enable more effective monitoring of drug effects in cancer prevention trials.

Scholarship Deadline: November 7 2005

Discounted Abstract Deadline: November 7 2005

Abstract Deadline: November 29 2005

Discounted Registration Deadline: January 6 2006

We gratefully acknowledge additional support for this conference from:

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program


Monday, March 06 \| 3:00PM - 7:30PM Registration Room: Pre-Function
Monday, March 06 \| 7:30PM - 8:30PM Keynote Address Room: Mountain/Lake Rooms Speaker 1 of 1 Waun Ki Hong, University of Texas MD Anderson Cancer Center, USA Convergence of Molecular Targets for Cancer Therapy and Prevention
Tuesday, March 07 \| 7:00AM - 8:00AM Breakfast Room: Granhall
Tuesday, March 07 \| 8:00AM - 11:15AM Inflammation, Immune Response and Cancer Risk Room: Mountain/Lake Rooms Speaker 1 of 6 * Madhav V. Dhodapkar, Yale School of Medicine, USA Harnessing Host Immune Response to Preneoplasia
Tuesday, March 07 \| 8:00AM - 11:15AM Inflammation, Immune Response and Cancer Risk Room: Mountain/Lake Rooms Speaker 2 of 6 Steven M. Dubinett, University of California, Los Angeles, USA COX-2, Immune Modulation and Lung Cancer
Tuesday, March 07 \| 8:00AM - 11:15AM Inflammation, Immune Response and Cancer Risk Room: Mountain/Lake Rooms Speaker 3 of 6 Angelo De Marzo, Johns Hopkins School of Medicine, USA Inflammation, Atrophy and Prostate Carcinogenesis
Tuesday, March 07 \| 8:00AM - 11:15AM Inflammation, Immune Response and Cancer Risk Room: Mountain/Lake Rooms Speaker 4 of 6 Claire E. Lewis, University of Sheffield Medical School, UK The Hypoxic Macrophage: A Driving Force in Tumor Progression
Tuesday, March 07 \| 8:00AM - 11:15AM Inflammation, Immune Response and Cancer Risk Room: Mountain/Lake Rooms Speaker 5 of 6 Connie P. Matthews, National Cancer Institute at Frederick, USA Short Talk: Cox-2 and Other Inflammatory Response Proteins Mediate Prevention of Human Papilloma Virus (HPV) E7-Driven Tumorigenesis by Dominant Negative cJun (TAM67)
Tuesday, March 07 \| 8:00AM - 11:15AM Inflammation, Immune Response and Cancer Risk Room: Mountain/Lake Rooms Speaker 6 of 6 Ling-Min Lu, McMaster University, Canada Short Talk: Cigarette Smoke Impairs NK-Dependent Tumor Immune Surveillance and Immune-Based Intervention
Tuesday, March 07 \| 9:20AM - 9:40AM Coffee Break Room: Pre-Function
Tuesday, March 07 \| 11:15AM - 1:00PM Poster Setup Room: Bay Room
Tuesday, March 07 \| 1:00PM - 10:00PM Poster Viewing Room: Bay Room
Tuesday, March 07 \| 2:30PM - 4:30PM Workshop 1 Room: Mountain/Lake Rooms Speaker 1 of 9 * John M. Pezzuto, USA Molecular Targeting by Natural Preventive Agents
Tuesday, March 07 \| 2:30PM - 4:30PM Workshop 1 Room: Mountain/Lake Rooms Speaker 2 of 9 Chinthalapally V. Rao, University of Oklahoma Health Sciences Center, USA Molecular Targets for Colon Cancer Prevention
Tuesday, March 07 \| 2:30PM - 4:30PM Workshop 1 Room: Mountain/Lake Rooms Speaker 3 of 9 David S. Franklin, Purdue University, USA RET2A / Cell Cycle Signaling during MEN2 Tumorigenesis: Implication in Novel Molecular Targets for Cancer Treatment
Tuesday, March 07 \| 2:30PM - 4:30PM Workshop 1 Room: Mountain/Lake Rooms Speaker 4 of 9 Katie M. Ruocco, National Cancer Institute, National Institutes of Health, USA Targeting Transcription Factors: A High Throughput Screen to Identify Natural Product Inhibitors of AP-1
Tuesday, March 07 \| 2:30PM - 4:30PM Workshop 1 Room: Mountain/Lake Rooms Speaker 5 of 9 Jing Y. Han, St. John's University, USA Role of GADD Genes in the ER-stress-induced Apoptotic Response of C33A Human Cervical Carcinoma Cells exposed to 3,3’-Diindolylmethane
Tuesday, March 07 \| 2:30PM - 4:30PM Workshop 1 Room: Mountain/Lake Rooms Speaker 6 of 9 † Emmanuelle J. Meuillet, University of Arizona, USA Selenium Increases the Activity of the Tumor Suppressor Protein, PTEN via the Thioredoxin-Thioredoxin Reductase System by Decreasing Phospho-Thr382/383PTEN in Prostate Cancer Cells
Tuesday, March 07 \| 2:30PM - 4:30PM Workshop 1 Room: Mountain/Lake Rooms Speaker 7 of 9 Daniel Sliva, Methodist Research Institute, USA Suppression of Cancer Proliferation and Invasiveness by Natural Terpenoids
Tuesday, March 07 \| 2:30PM - 4:30PM Workshop 1 Room: Mountain/Lake Rooms Speaker 8 of 9 Satoko Aoki, Tokyo University of Science, Japan Screening of The Target Molecule for Sulfoquinovosylacylglycerol., Novel Anti-Tumor Agents
Tuesday, March 07 \| 2:30PM - 4:30PM Workshop 1 Room: Mountain/Lake Rooms Speaker 9 of 9 Fuzhi Lian, JM USDA Human Nutrition Research Center on Aging, USA Beta-Cryptoxanthin Inhibits The Growth of Immortalized Human Bronchia Epithelial Cells and Non-Small Cell Lung Cancer Cells and Up-Regulates Retinoic Acid Receptor beta Expression
Tuesday, March 07 \| 4:30PM - 5:00PM Coffee Available Room: Pre-Function
Tuesday, March 07 \| 5:00PM - 7:00PM Targeting Translation Initiation Room: Mountain/Lake Rooms Speaker 1 of 4 * Nahum Sonenberg, McGill University, Canada How Does eIF4E Transform Cells?
Tuesday, March 07 \| 5:00PM - 7:00PM Targeting Translation Initiation Room: Mountain/Lake Rooms Speaker 2 of 4 Nancy H. Colburn, National Institutes of Health, USA Pdcd4 Targets eIF4A to Inhibit Translation, Transcription Tumorigenesis, and Invasion
Tuesday, March 07 \| 5:00PM - 7:00PM Targeting Translation Initiation Room: Mountain/Lake Rooms Speaker 3 of 4 Rakesh Kumar, University of Texas MD Anderson Cancer Center, USA Signaling, RNA-Binding Proteins and Cancer
Tuesday, March 07 \| 5:00PM - 7:00PM Targeting Translation Initiation Room: Mountain/Lake Rooms Speaker 4 of 4 Hsin-Sheng Yang, University of Kentucky College of Medicine, USA Short Talk: Pdcd4, a Novel Target for Colorectal Cancer Prevention
Tuesday, March 07 \| 7:00PM - 8:00PM Dinner Room: Granhall
Tuesday, March 07 \| 8:00PM - 10:00PM Poster Session 1 Room: Bay Room
Tuesday, March 07 \| 8:00PM - 9:00PM Social Hour Room: Bay Room
Wednesday, March 08 \| 7:00AM - 8:00AM Breakfast Room: Granhall
Wednesday, March 08 \| 8:00AM - 11:15AM Bioactive Lipids and Cancer Prevention Room: Mountain/Lake Rooms Speaker 1 of 6 * Scott M. Lippman, UC San Diego Moores Cancer Center, USA Targeting 15-LOX-1 to Induce Apoptosis
Wednesday, March 08 \| 8:00AM - 11:15AM Bioactive Lipids and Cancer Prevention Room: Mountain/Lake Rooms Speaker 2 of 6 Kenneth V. Honn, Wayne State University, USA 12-LOX, Angiogenesis and Cancer
Wednesday, March 08 \| 8:00AM - 11:15AM Bioactive Lipids and Cancer Prevention Room: Mountain/Lake Rooms Speaker 3 of 6 Andrew J. Dannenberg, Weill Medical College of Cornell University, USA The PGE2-Aromatase Connection
Wednesday, March 08 \| 8:00AM - 11:15AM Bioactive Lipids and Cancer Prevention Room: Mountain/Lake Rooms Speaker 4 of 6 Masanobu Oshima, Kanazawa University, Japan Stromal Eicosanoids and Gastric Tumorigenesis
Wednesday, March 08 \| 8:00AM - 11:15AM Bioactive Lipids and Cancer Prevention Room: Mountain/Lake Rooms Speaker 5 of 6 Jason R. Mann, Vanderbilt University, USA Short Talk: Repression of Prostaglandin Catabolism Disrupts the Epithelial Differentiation Program and Promotes Tumorigenesis
Wednesday, March 08 \| 8:00AM - 11:15AM Bioactive Lipids and Cancer Prevention Room: Mountain/Lake Rooms Speaker 6 of 6 Dipti J. Mehta, University of Arizona, USA Short Talk: 15-Deoxy-Delta12,14-Prostaglandin J2(15d-PGJ2) Mediated Apoptotic Signaling in Colon Cancer Cells
Wednesday, March 08 \| 9:20AM - 9:40AM Coffee Break Room: Pre-Function
Wednesday, March 08 \| 11:15AM - 1:00PM Poster Setup Room: Bay Room
Wednesday, March 08 \| 1:00PM - 10:00PM Poster Viewing Room: Bay Room
Wednesday, March 08 \| 2:30PM - 4:30PM Roundtable Discussion: Clinical Challenges of Developing Pre ventive Agents: Perspectives from Academia, Industry, the NCI, and the FDA Room: Mountain/Lake Rooms Speaker 1 of 7 * Powel H. Brown, Baylor College of Medicine, USA
Wednesday, March 08 \| 2:30PM - 4:30PM Roundtable Discussion: Clinical Challenges of Developing Pre ventive Agents: Perspectives from Academia, Industry, the NCI, and the FDA Room: Mountain/Lake Rooms Speaker 2 of 7 Carl Barrett, AstraZeneca, USA
Wednesday, March 08 \| 2:30PM - 4:30PM Roundtable Discussion: Clinical Challenges of Developing Pre ventive Agents: Perspectives from Academia, Industry, the NCI, and the FDA Room: Mountain/Lake Rooms Speaker 3 of 7 Ernest Hawk, National Cancer Institute, National Institutes of Health, USA
Wednesday, March 08 \| 2:30PM - 4:30PM Roundtable Discussion: Clinical Challenges of Developing Pre ventive Agents: Perspectives from Academia, Industry, the NCI, and the FDA Room: Mountain/Lake Rooms Speaker 4 of 7 Leslie Ford, National Cancer Institute, National Institutes of Health, USA
Wednesday, March 08 \| 2:30PM - 4:30PM Roundtable Discussion: Clinical Challenges of Developing Pre ventive Agents: Perspectives from Academia, Industry, the NCI, and the FDA Room: Mountain/Lake Rooms Speaker 5 of 7 Ann Farrell, U.S. Food and Drug Administration, USA
Wednesday, March 08 \| 2:30PM - 4:30PM Roundtable Discussion: Clinical Challenges of Developing Pre ventive Agents: Perspectives from Academia, Industry, the NCI, and the FDA Room: Mountain/Lake Rooms Speaker 6 of 7 Pablo J. Cagnoni, Tizona Therapeutics, USA
Wednesday, March 08 \| 2:30PM - 4:30PM Roundtable Discussion: Clinical Challenges of Developing Pre ventive Agents: Perspectives from Academia, Industry, the NCI, and the FDA Room: Mountain/Lake Rooms Speaker 7 of 7 Gary Gordon, Abbott Laboratories, USA
Wednesday, March 08 \| 4:30PM - 5:00PM Coffee Available Room: Pre-Function
Wednesday, March 08 \| 5:00PM - 7:00PM Stromal - Epithelial Interactions Room: Mountain/Lake Rooms Speaker 1 of 4 * Thea D. Tlsty, University of California, San Francisco, USA Genetic and Epigenetic Changes in Early Carcinogenesis
Wednesday, March 08 \| 5:00PM - 7:00PM Stromal - Epithelial Interactions Room: Mountain/Lake Rooms Speaker 2 of 4 Lisa M. Coussens, Oregon Health & Science University, USA Inflammation and Cancer Development
Wednesday, March 08 \| 5:00PM - 7:00PM Stromal - Epithelial Interactions Room: Mountain/Lake Rooms Speaker 3 of 4 Harold L. Moses, Vanderbilt University, USA Stromal TGF-beta Signaling in Cancer
Wednesday, March 08 \| 5:00PM - 7:00PM Stromal - Epithelial Interactions Room: Mountain/Lake Rooms Speaker 4 of 4 Sandra S. McAllister, Brigham & Women's Hospital/Harvard Medical School, USA Short Talk: Recruitment of Tumor Stromal Cells and Bone Marrow Support of Tumor Progression
Wednesday, March 08 \| 7:00PM - 8:00PM Dinner Room: Granhall
Wednesday, March 08 \| 8:00PM - 10:00PM Poster Session 2 Room: Bay Room
Wednesday, March 08 \| 8:00PM - 9:00PM Social Hour Room: Bay Room
Thursday, March 09 \| 7:00AM - 8:00AM Breakfast Room: Granhall
Thursday, March 09 \| 8:00AM - 11:00AM Obesity and Cancer Risk Room: Mountain/Lake Rooms Speaker 1 of 6 * Leslie Bernstein, University of Southern California, USA Obesity, Physical Inactivity and Cancer Risk: Etiologic Insights
Thursday, March 09 \| 8:00AM - 11:00AM Obesity and Cancer Risk Room: Mountain/Lake Rooms Speaker 2 of 6 Michael Pollak, Jewish General Hospital, Canada Insulin Resistance, IGFs and Cancer
Thursday, March 09 \| 8:00AM - 11:00AM Obesity and Cancer Risk Room: Mountain/Lake Rooms Speaker 3 of 6 Carl Barrett, AstraZeneca, USA HIF-1, Obesity and Cancer
Thursday, March 09 \| 8:00AM - 11:00AM Obesity and Cancer Risk Room: Mountain/Lake Rooms Speaker 4 of 6 Helen Kim, University of Alabama at Birmingham, USA Proteomics of Dietary Polyphenols on Brain Proteins: What it Predicts about Chemopreventive Activities of the Same Polyphenols
Thursday, March 09 \| 8:00AM - 11:00AM Obesity and Cancer Risk Room: Mountain/Lake Rooms Speaker 5 of 6 Lesley A. Mathews, NCI, USA Short Talk: Effect of Insulin-like Growth Factor-I on Parity Induced Protection against Breast Cancer
Thursday, March 09 \| 8:00AM - 11:00AM Obesity and Cancer Risk Room: Mountain/Lake Rooms Speaker 6 of 6 Daqing Yang, University of South Dakota, Sanford School of Medicine, USA Short Talk: The Identification of an Internal Ribosomal Entry Site in the p53 mRNA Provides a Novel Mechanism for the Regulation of its Translation Following DNA Damage
Thursday, March 09 \| 9:20AM - 9:40AM Coffee Break Room: Pre-Function
Thursday, March 09 \| 2:30PM - 4:30PM Workshop 2 Room: Mountain/Lake Rooms Speaker 1 of 5 * Rakesh Kumar, University of Texas MD Anderson Cancer Center, USA
Thursday, March 09 \| 2:30PM - 4:30PM Workshop 2 Room: Mountain/Lake Rooms Speaker 2 of 5 * John V. Heymach, University of Texas MD Anderson Cancer Center, USA Angiogenesis and Vascular Targeting in Early Tumorigenesis
Thursday, March 09 \| 2:30PM - 4:30PM Workshop 2 Room: Mountain/Lake Rooms Speaker 3 of 5 Fabian Benencia, Ohio University, USA Tumor-Associated Mature Dendritic Cells Show Express MMP9 and VEGF and Contribute to Tumor Angiogenesis
Thursday, March 09 \| 2:30PM - 4:30PM Workshop 2 Room: Mountain/Lake Rooms Speaker 4 of 5 Matthew J. Rioth, Children's Hospital Boston, USA Dysregulation of the Calcineurin-NFAT Pathway in DSCR1 -/- Mice Leads to Decreased Tumorigenesis and Impaired Endothelial Cell Function
Thursday, March 09 \| 2:30PM - 4:30PM Workshop 2 Room: Mountain/Lake Rooms Speaker 5 of 5 Keisuke Ohta, Tokyo University of Science, Japan Anti-Angiogenesis Activity of Sulfoquinovosylacylglycerols
Thursday, March 09 \| 4:30PM - 5:00PM Coffee Available Room: Pre-Function
Thursday, March 09 \| 5:00PM - 7:15PM Biomarkers in Cancer Detection and Prevention Room: Mountain/Lake Rooms Speaker 1 of 5 * Gordon B. Mills, University of Texas MD Anderson Cancer Center, USA Biomarkers in Cancer Prevention
Thursday, March 09 \| 5:00PM - 7:15PM Biomarkers in Cancer Detection and Prevention Room: Mountain/Lake Rooms Speaker 2 of 5 Harvey R. Herschman, University of California, Los Angeles, USA 'Molecular Imaging in Monitoring Cancer Initiation, Promotion and Progression.'
Thursday, March 09 \| 5:00PM - 7:15PM Biomarkers in Cancer Detection and Prevention Room: Mountain/Lake Rooms Speaker 3 of 5 David F. Ransohoff, University of North Carolina at Chapel Hill, USA Improving Efficiency and Reliability of Evaluations of Biomarkers for Cancer
Thursday, March 09 \| 5:00PM - 7:15PM Biomarkers in Cancer Detection and Prevention Room: Mountain/Lake Rooms Speaker 4 of 5 † Ralph G. Zinner, University of Texas MD Anderson Cancer Center, USA Short Talk: Medicinal Algorithmic Combinatorial Screen (MACS): A Novel Approach to Identify New Therapeutic Regimens
Thursday, March 09 \| 5:00PM - 7:15PM Biomarkers in Cancer Detection and Prevention Room: Mountain/Lake Rooms Speaker 5 of 5 Candy Lee, Angion Biomedica Corp, USA Short Talk: Proteomic Analysis of Colon Adenocarcinoma Identified Novel Targets for Therapy
Thursday, March 09 \| 7:15PM - 8:15PM Social Hour Room: Granhall
Thursday, March 09 \| 8:00PM - 11:00PM Entertainment Room: Mountain/Lake Rooms
Thursday, March 09 \| 8:15PM - 11:00PM Cash Bar Room: Mountain/Lake Rooms
Thursday, March 09 \| 8:15PM - 9:15PM Dinner Room: Mountain/Lake Rooms
Friday, March 10 \| 10:26AM - 10:26AM Departure *Session Chair.