Web Desc
Molecular Targets for Cancer Prevention
Organizer(s): Scott M. Lippman, Nancy H. Colburn and Andrew J. Dannenberg
Date: March 06 - 10, 2006
Location: Granlibakken Tahoe, Tahoe City, CA, USA
Supported by The Director's Fund
Summary of Meeting:
The most promising directions in cancer prevention lie in the early identification of high-risk individuals and the development of targeted interventions to prevent or delay carcinogenesis. A revolution in molecular studies and drug development has blurred the distinction between malignancy and pre-malignancy and between cancer therapy and prevention. Molecular targeted agents have produced major clinical advances in randomized controlled cancer prevention trials. Inflammation and obesity have emerged as important risk factors and provide new molecular targets for prevention such as HIF-1 and IGF-1. Molecular studies of fatty acid metabolism and stromal-epithelial interactions in carcinogenesis have identified targets such as cyclooxygenases, lipoxygenases, ECM proteases, and TGF-beta. Translation joins transcription as a new gene-regulation target for interventions; translationally regulated targets include c-myc and ODC. Imaging and proteomics have revealed new biomarkers that enable the early detection of cancer and enable more effective monitoring of drug effects in cancer prevention trials.
Scholarship Deadline: November 7 2005
Discounted Abstract Deadline: November 7 2005
Abstract Deadline: November 29 2005
Discounted Registration Deadline: January 6 2006
We gratefully acknowledge additional support for this conference from:
Novartis Institutes for BioMedical Research
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Monday, March 06 | 3:00PM - 7:30PM
Registration
Room: Pre-Function


Monday, March 06 | 7:30PM - 8:30PM
Keynote Address
Room: Mountain/Lake Rooms

Speaker 1 of 1
Waun Ki Hong, University of Texas MD Anderson Cancer Center, USA
Convergence of Molecular Targets for Cancer Therapy and Prevention

Tuesday, March 07 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Tuesday, March 07 | 8:00AM - 11:15AM
Inflammation, Immune Response and Cancer Risk
Room: Mountain/Lake Rooms

Speaker 1 of 6
* Madhav V. Dhodapkar, Yale School of Medicine, USA
Harnessing Host Immune Response to Preneoplasia

Tuesday, March 07 | 8:00AM - 11:15AM
Inflammation, Immune Response and Cancer Risk
Room: Mountain/Lake Rooms

Speaker 2 of 6
Steven M. Dubinett, University of California, Los Angeles, USA
COX-2, Immune Modulation and Lung Cancer

Tuesday, March 07 | 8:00AM - 11:15AM
Inflammation, Immune Response and Cancer Risk
Room: Mountain/Lake Rooms

Speaker 3 of 6
Angelo De Marzo, Johns Hopkins School of Medicine, USA
Inflammation, Atrophy and Prostate Carcinogenesis

Tuesday, March 07 | 8:00AM - 11:15AM
Inflammation, Immune Response and Cancer Risk
Room: Mountain/Lake Rooms

Speaker 4 of 6
Claire E. Lewis, University of Sheffield Medical School, UK
The Hypoxic Macrophage: A Driving Force in Tumor Progression

Tuesday, March 07 | 8:00AM - 11:15AM
Inflammation, Immune Response and Cancer Risk
Room: Mountain/Lake Rooms

Speaker 5 of 6
Connie P. Matthews, National Cancer Institute at Frederick, USA
Short Talk: Cox-2 and Other Inflammatory Response Proteins Mediate Prevention of Human Papilloma Virus (HPV) E7-Driven Tumorigenesis by Dominant Negative cJun (TAM67)

Tuesday, March 07 | 8:00AM - 11:15AM
Inflammation, Immune Response and Cancer Risk
Room: Mountain/Lake Rooms

Speaker 6 of 6
Ling-Min Lu, McMaster University, Canada
Short Talk: Cigarette Smoke Impairs NK-Dependent Tumor Immune Surveillance and Immune-Based Intervention

Tuesday, March 07 | 9:20AM - 9:40AM
Coffee Break
Room: Pre-Function


Tuesday, March 07 | 11:15AM - 1:00PM
Poster Setup
Room: Bay Room


Tuesday, March 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay Room


Tuesday, March 07 | 2:30PM - 4:30PM
Workshop 1
Room: Mountain/Lake Rooms

Speaker 1 of 9
* John M. Pezzuto, USA
Molecular Targeting by Natural Preventive Agents

Tuesday, March 07 | 2:30PM - 4:30PM
Workshop 1
Room: Mountain/Lake Rooms

Speaker 2 of 9
Chinthalapally V. Rao, University of Oklahoma Health Sciences Center, USA
Molecular Targets for Colon Cancer Prevention

Tuesday, March 07 | 2:30PM - 4:30PM
Workshop 1
Room: Mountain/Lake Rooms

Speaker 3 of 9
David S. Franklin, Purdue University, USA
RET2A / Cell Cycle Signaling during MEN2 Tumorigenesis: Implication in Novel Molecular Targets for Cancer Treatment

Tuesday, March 07 | 2:30PM - 4:30PM
Workshop 1
Room: Mountain/Lake Rooms

Speaker 4 of 9
Katie M. Ruocco, National Cancer Institute, National Institutes of Health, USA
Targeting Transcription Factors: A High Throughput Screen to Identify Natural Product Inhibitors of AP-1

Tuesday, March 07 | 2:30PM - 4:30PM
Workshop 1
Room: Mountain/Lake Rooms

Speaker 5 of 9
Jing Y. Han, St. John's University, USA
Role of GADD Genes in the ER-stress-induced Apoptotic Response of C33A Human Cervical Carcinoma Cells exposed to 3,3’-Diindolylmethane

Tuesday, March 07 | 2:30PM - 4:30PM
Workshop 1
Room: Mountain/Lake Rooms

Speaker 6 of 9
† Emmanuelle J. Meuillet, University of Arizona, USA
Selenium Increases the Activity of the Tumor Suppressor Protein, PTEN via the Thioredoxin-Thioredoxin Reductase System by Decreasing Phospho-Thr382/383PTEN in Prostate Cancer Cells

Tuesday, March 07 | 2:30PM - 4:30PM
Workshop 1
Room: Mountain/Lake Rooms

Speaker 7 of 9
Daniel Sliva, Methodist Research Institute, USA
Suppression of Cancer Proliferation and Invasiveness by Natural Terpenoids

Tuesday, March 07 | 2:30PM - 4:30PM
Workshop 1
Room: Mountain/Lake Rooms

Speaker 8 of 9
Satoko Aoki, Tokyo University of Science, Japan
Screening of The Target Molecule for Sulfoquinovosylacylglycerol., Novel Anti-Tumor Agents

Tuesday, March 07 | 2:30PM - 4:30PM
Workshop 1
Room: Mountain/Lake Rooms

Speaker 9 of 9
Fuzhi Lian, JM USDA Human Nutrition Research Center on Aging, USA
Beta-Cryptoxanthin Inhibits The Growth of Immortalized Human Bronchia Epithelial Cells and Non-Small Cell Lung Cancer Cells and Up-Regulates Retinoic Acid Receptor beta Expression

Tuesday, March 07 | 4:30PM - 5:00PM
Coffee Available
Room: Pre-Function


Tuesday, March 07 | 5:00PM - 7:00PM
Targeting Translation Initiation
Room: Mountain/Lake Rooms

Speaker 1 of 4
* Nahum Sonenberg, McGill University, Canada
How Does eIF4E Transform Cells?

Tuesday, March 07 | 5:00PM - 7:00PM
Targeting Translation Initiation
Room: Mountain/Lake Rooms

Speaker 2 of 4
Nancy H. Colburn, National Institutes of Health, USA
Pdcd4 Targets eIF4A to Inhibit Translation, Transcription Tumorigenesis, and Invasion

Tuesday, March 07 | 5:00PM - 7:00PM
Targeting Translation Initiation
Room: Mountain/Lake Rooms

Speaker 3 of 4
Rakesh Kumar, University of Texas MD Anderson Cancer Center, USA
Signaling, RNA-Binding Proteins and Cancer

Tuesday, March 07 | 5:00PM - 7:00PM
Targeting Translation Initiation
Room: Mountain/Lake Rooms

Speaker 4 of 4
Hsin-Sheng Yang, University of Kentucky College of Medicine, USA
Short Talk: Pdcd4, a Novel Target for Colorectal Cancer Prevention

Tuesday, March 07 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Tuesday, March 07 | 8:00PM - 10:00PM
Poster Session 1
Room: Bay Room


Tuesday, March 07 | 8:00PM - 9:00PM
Social Hour
Room: Bay Room


Wednesday, March 08 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Wednesday, March 08 | 8:00AM - 11:15AM
Bioactive Lipids and Cancer Prevention
Room: Mountain/Lake Rooms

Speaker 1 of 6
* Scott M. Lippman, UC San Diego Moores Cancer Center, USA
Targeting 15-LOX-1 to Induce Apoptosis

Wednesday, March 08 | 8:00AM - 11:15AM
Bioactive Lipids and Cancer Prevention
Room: Mountain/Lake Rooms

Speaker 2 of 6
Kenneth V. Honn, Wayne State University, USA
12-LOX, Angiogenesis and Cancer

Wednesday, March 08 | 8:00AM - 11:15AM
Bioactive Lipids and Cancer Prevention
Room: Mountain/Lake Rooms

Speaker 3 of 6
Andrew J. Dannenberg, Weill Medical College of Cornell University, USA
The PGE2-Aromatase Connection

Wednesday, March 08 | 8:00AM - 11:15AM
Bioactive Lipids and Cancer Prevention
Room: Mountain/Lake Rooms

Speaker 4 of 6
Masanobu Oshima, Kanazawa University, Japan
Stromal Eicosanoids and Gastric Tumorigenesis

Wednesday, March 08 | 8:00AM - 11:15AM
Bioactive Lipids and Cancer Prevention
Room: Mountain/Lake Rooms

Speaker 5 of 6
Jason R. Mann, Vanderbilt University, USA
Short Talk: Repression of Prostaglandin Catabolism Disrupts the Epithelial Differentiation Program and Promotes Tumorigenesis

Wednesday, March 08 | 8:00AM - 11:15AM
Bioactive Lipids and Cancer Prevention
Room: Mountain/Lake Rooms

Speaker 6 of 6
Dipti J. Mehta, University of Arizona, USA
Short Talk: 15-Deoxy-Delta12,14-Prostaglandin J2(15d-PGJ2) Mediated Apoptotic Signaling in Colon Cancer Cells

Wednesday, March 08 | 9:20AM - 9:40AM
Coffee Break
Room: Pre-Function


Wednesday, March 08 | 11:15AM - 1:00PM
Poster Setup
Room: Bay Room


Wednesday, March 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Bay Room


Wednesday, March 08 | 2:30PM - 4:30PM
Roundtable Discussion: Clinical Challenges of Developing Pre
ventive Agents: Perspectives from Academia, Industry, the NCI, and the FDA
Room: Mountain/Lake Rooms

Speaker 1 of 7
* Powel H. Brown, Baylor College of Medicine, USA

Wednesday, March 08 | 2:30PM - 4:30PM
Roundtable Discussion: Clinical Challenges of Developing Pre
ventive Agents: Perspectives from Academia, Industry, the NCI, and the FDA
Room: Mountain/Lake Rooms

Speaker 2 of 7
Carl Barrett, AstraZeneca, USA

Wednesday, March 08 | 2:30PM - 4:30PM
Roundtable Discussion: Clinical Challenges of Developing Pre
ventive Agents: Perspectives from Academia, Industry, the NCI, and the FDA
Room: Mountain/Lake Rooms

Speaker 3 of 7
Ernest Hawk, National Cancer Institute, National Institutes of Health, USA

Wednesday, March 08 | 2:30PM - 4:30PM
Roundtable Discussion: Clinical Challenges of Developing Pre
ventive Agents: Perspectives from Academia, Industry, the NCI, and the FDA
Room: Mountain/Lake Rooms

Speaker 4 of 7
Leslie Ford, National Cancer Institute, National Institutes of Health, USA

Wednesday, March 08 | 2:30PM - 4:30PM
Roundtable Discussion: Clinical Challenges of Developing Pre
ventive Agents: Perspectives from Academia, Industry, the NCI, and the FDA
Room: Mountain/Lake Rooms

Speaker 5 of 7
Ann Farrell, U.S. Food and Drug Administration, USA

Wednesday, March 08 | 2:30PM - 4:30PM
Roundtable Discussion: Clinical Challenges of Developing Pre
ventive Agents: Perspectives from Academia, Industry, the NCI, and the FDA
Room: Mountain/Lake Rooms

Speaker 6 of 7
Pablo J. Cagnoni, Tizona Therapeutics, USA

Wednesday, March 08 | 2:30PM - 4:30PM
Roundtable Discussion: Clinical Challenges of Developing Pre
ventive Agents: Perspectives from Academia, Industry, the NCI, and the FDA
Room: Mountain/Lake Rooms

Speaker 7 of 7
Gary Gordon, Abbott Laboratories, USA

Wednesday, March 08 | 4:30PM - 5:00PM
Coffee Available
Room: Pre-Function


Wednesday, March 08 | 5:00PM - 7:00PM
Stromal - Epithelial Interactions
Room: Mountain/Lake Rooms

Speaker 1 of 4
* Thea D. Tlsty, University of California, San Francisco, USA
Genetic and Epigenetic Changes in Early Carcinogenesis

Wednesday, March 08 | 5:00PM - 7:00PM
Stromal - Epithelial Interactions
Room: Mountain/Lake Rooms

Speaker 2 of 4
Lisa M. Coussens, Oregon Health & Science University, USA
Inflammation and Cancer Development

Wednesday, March 08 | 5:00PM - 7:00PM
Stromal - Epithelial Interactions
Room: Mountain/Lake Rooms

Speaker 3 of 4
Harold L. Moses, Vanderbilt University, USA
Stromal TGF-beta Signaling in Cancer

Wednesday, March 08 | 5:00PM - 7:00PM
Stromal - Epithelial Interactions
Room: Mountain/Lake Rooms

Speaker 4 of 4
Sandra S. McAllister, Brigham & Women's Hospital/Harvard Medical School, USA
Short Talk: Recruitment of Tumor Stromal Cells and Bone Marrow Support of Tumor Progression

Wednesday, March 08 | 7:00PM - 8:00PM
Dinner
Room: Granhall


Wednesday, March 08 | 8:00PM - 10:00PM
Poster Session 2
Room: Bay Room


Wednesday, March 08 | 8:00PM - 9:00PM
Social Hour
Room: Bay Room


Thursday, March 09 | 7:00AM - 8:00AM
Breakfast
Room: Granhall


Thursday, March 09 | 8:00AM - 11:00AM
Obesity and Cancer Risk
Room: Mountain/Lake Rooms

Speaker 1 of 6
* Leslie Bernstein, University of Southern California, USA
Obesity, Physical Inactivity and Cancer Risk: Etiologic Insights

Thursday, March 09 | 8:00AM - 11:00AM
Obesity and Cancer Risk
Room: Mountain/Lake Rooms

Speaker 2 of 6
Michael Pollak, Jewish General Hospital, Canada
Insulin Resistance, IGFs and Cancer

Thursday, March 09 | 8:00AM - 11:00AM
Obesity and Cancer Risk
Room: Mountain/Lake Rooms

Speaker 3 of 6
Carl Barrett, AstraZeneca, USA
HIF-1, Obesity and Cancer

Thursday, March 09 | 8:00AM - 11:00AM
Obesity and Cancer Risk
Room: Mountain/Lake Rooms

Speaker 4 of 6
Helen Kim, University of Alabama at Birmingham, USA
Proteomics of Dietary Polyphenols on Brain Proteins: What it Predicts about Chemopreventive Activities of the Same Polyphenols

Thursday, March 09 | 8:00AM - 11:00AM
Obesity and Cancer Risk
Room: Mountain/Lake Rooms

Speaker 5 of 6
Lesley A. Mathews, NCI, USA
Short Talk: Effect of Insulin-like Growth Factor-I on Parity Induced Protection against Breast Cancer

Thursday, March 09 | 8:00AM - 11:00AM
Obesity and Cancer Risk
Room: Mountain/Lake Rooms

Speaker 6 of 6
Daqing Yang, University of South Dakota, Sanford School of Medicine, USA
Short Talk: The Identification of an Internal Ribosomal Entry Site in the p53 mRNA Provides a Novel Mechanism for the Regulation of its Translation Following DNA Damage

Thursday, March 09 | 9:20AM - 9:40AM
Coffee Break
Room: Pre-Function


Thursday, March 09 | 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake Rooms

Speaker 1 of 5
* Rakesh Kumar, University of Texas MD Anderson Cancer Center, USA

Thursday, March 09 | 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake Rooms

Speaker 2 of 5
* John V. Heymach, University of Texas MD Anderson Cancer Center, USA
Angiogenesis and Vascular Targeting in Early Tumorigenesis

Thursday, March 09 | 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake Rooms

Speaker 3 of 5
Fabian Benencia, Ohio University, USA
Tumor-Associated Mature Dendritic Cells Show Express MMP9 and VEGF and Contribute to Tumor Angiogenesis

Thursday, March 09 | 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake Rooms

Speaker 4 of 5
Matthew J. Rioth, Children's Hospital Boston, USA
Dysregulation of the Calcineurin-NFAT Pathway in DSCR1 -/- Mice Leads to Decreased Tumorigenesis and Impaired Endothelial Cell Function

Thursday, March 09 | 2:30PM - 4:30PM
Workshop 2
Room: Mountain/Lake Rooms

Speaker 5 of 5
Keisuke Ohta, Tokyo University of Science, Japan
Anti-Angiogenesis Activity of Sulfoquinovosylacylglycerols

Thursday, March 09 | 4:30PM - 5:00PM
Coffee Available
Room: Pre-Function


Thursday, March 09 | 5:00PM - 7:15PM
Biomarkers in Cancer Detection and Prevention
Room: Mountain/Lake Rooms

Speaker 1 of 5
* Gordon B. Mills, University of Texas MD Anderson Cancer Center, USA
Biomarkers in Cancer Prevention

Thursday, March 09 | 5:00PM - 7:15PM
Biomarkers in Cancer Detection and Prevention
Room: Mountain/Lake Rooms

Speaker 2 of 5
Harvey R. Herschman, University of California, Los Angeles, USA
'Molecular Imaging in Monitoring Cancer Initiation, Promotion and Progression.'

Thursday, March 09 | 5:00PM - 7:15PM
Biomarkers in Cancer Detection and Prevention
Room: Mountain/Lake Rooms

Speaker 3 of 5
David F. Ransohoff, University of North Carolina at Chapel Hill, USA
Improving Efficiency and Reliability of Evaluations of Biomarkers for Cancer

Thursday, March 09 | 5:00PM - 7:15PM
Biomarkers in Cancer Detection and Prevention
Room: Mountain/Lake Rooms

Speaker 4 of 5
† Ralph G. Zinner, University of Texas MD Anderson Cancer Center, USA
Short Talk: Medicinal Algorithmic Combinatorial Screen (MACS): A Novel Approach to Identify New Therapeutic Regimens

Thursday, March 09 | 5:00PM - 7:15PM
Biomarkers in Cancer Detection and Prevention
Room: Mountain/Lake Rooms

Speaker 5 of 5
Candy Lee, Angion Biomedica Corp, USA
Short Talk: Proteomic Analysis of Colon Adenocarcinoma Identified Novel Targets for Therapy

Thursday, March 09 | 7:15PM - 8:15PM
Social Hour
Room: Granhall


Thursday, March 09 | 8:00PM - 11:00PM
Entertainment
Room: Mountain/Lake Rooms


Thursday, March 09 | 8:15PM - 11:00PM
Cash Bar
Room: Mountain/Lake Rooms


Thursday, March 09 | 8:15PM - 9:15PM
Dinner
Room: Mountain/Lake Rooms


Friday, March 10 | 10:26AM - 10:26AM
Departure


*Session Chair.