Web Desc
Tolerance, Autoimmunity and Immune Regulation
Organizer(s): David W. Scott, Rachel R. Caspi, Matthias G. von Herrath and Terry L. Delovitch
Date: March 21 - 26, 2006
Location: Beaver Run Resort, Breckenridge, CO, USA
Supported by The Director's Fund
Summary of Meeting:
Self versus non-self discrimination is one of the basic tenets of immunology. The pathways by which tolerance is established are complex but recent work has provided greater insight into this important process. Understanding how tolerance is induced and “broken” is critical to developing future therapies for a variety of autoimmune disorders, such as diabetes and multiple sclerosis. Novel approaches need to be developed for the treatment of the autoimmune disorders that lead to tissue target cell destruction. This Keystone meeting is centered at understanding tolerance and its breakdown, and bridging the gap between basic, pre-clinical and clinical studies. While there will be an emphasis on basic studies, disease models for dissecting pathogenesis and examining novel therapies in a variety of autoimmune diseases (e.g., diabetes, multiple sclerosis, IBD, uveitis, as well as hemophilia), which will provide a major focus. Thus, a major theme will be the underlying tolerance pathways, as well as how they are subverted. The establishment of new models and therapies, including human clinical trials, will be included. Sessions to be covered include studies of the genes and signals involved in tolerance and autoimmunity, the interaction of the innate and adaptive immune systems, novel approaches for tolerance induction in autoimmune models, and translation of these to human clinical trials. Proof of principle studies and new biotechnology approaches will also be emphasized. The goals of the meeting are the following: • To provide an understanding of the mechanisms of immune tolerance and its breakdown • To update the audience on autoimmune models and clinical trials. • To stimulate interactions between basic and clinical scientists, as well as R & D scientists in industry, from around the globe to collaborate to respond to the challenges in this area. A novel feature this year is the addition of a formal debate session in the evening of the second day, as well as the presentation of the Lifetime Achievement Awards, with a brief historical overview. Workshops will be designed to be interactive rather than shorter plenary-type talks.
Scholarship Deadline: November 21 2005
Discounted Abstract Deadline: November 21 2005
Abstract Deadline: December 14 2005
Discounted Registration Deadline: January 20 2006
We gratefully acknowledge additional support for this conference from:
Educational donation provided by AmgenJDRFNational Multiple Sclerosis SocietyNovartis Institutes for BioMedical Research
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13 AI068401-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, March 21 | 3:00PM - 7:30PM
Registration
Room: Foyer


Tuesday, March 21 | 6:30PM - 7:30PM
Refreshments
Room: Foyer


Tuesday, March 21 | 7:30PM - 8:30PM
Keynote Address
Room: Peaks 1-5

Speaker 1 of 1
Diane Mathis, Harvard Medical School, USA
Immunogenetics of Autoimmunity

Wednesday, March 22 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Wednesday, March 22 | 8:00AM - 12:00PM
Genes and Signals in Immune Regulation
Room: Peaks 1-5

Speaker 1 of 6
Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
Transciptional Programs in T Cells: FoxP3 Controls T Regulatory Functions through Cooperation with NFAT

Wednesday, March 22 | 8:00AM - 12:00PM
Genes and Signals in Immune Regulation
Room: Peaks 1-5

Speaker 2 of 6
Kristin A. Hogquist, University of Minnesota, USA
Genetic Changes Underlying Positive Selection: KLF2 and Thymus Emigration

Wednesday, March 22 | 8:00AM - 12:00PM
Genes and Signals in Immune Regulation
Room: Peaks 1-5

Speaker 3 of 6
Dario A. A. Vignali, University of Pittsburgh School of Medicine, USA
Short Talk: What is the TCR Signaling Strength Required to Induce Tolerance and Functions

Wednesday, March 22 | 8:00AM - 12:00PM
Genes and Signals in Immune Regulation
Room: Peaks 1-5

Speaker 4 of 6
Signe J. Hässler, Uppsala University, Sweden
Short Talk: The Function of Aire in Dendritic Cells and Peripheral Tolerance

Wednesday, March 22 | 8:00AM - 12:00PM
Genes and Signals in Immune Regulation
Room: Peaks 1-5

Speaker 5 of 6
Elizabeth A. Wohlfert, NIAID, National Institutes of Health, USA
Short Talk: Regulatory T Cells Represent a Novel Target for the Immunoregulatory Effects of PPAR-gamma Ligands

Wednesday, March 22 | 8:00AM - 12:00PM
Genes and Signals in Immune Regulation
Room: Peaks 1-5

Speaker 6 of 6
Steven F. Ziegler, Benaroya Research Institute, USA
FoxP3 and Regulatory T Cells in Mice and Men

Wednesday, March 22 | 9:40AM - 10:00AM
Coffee Break
Room: Foyer


Wednesday, March 22 | 12:00PM - 1:00PM
Poster Setup
Room: Peaks 14-17


Wednesday, March 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 14-17


Wednesday, March 22 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, March 22 | 5:00PM - 6:30PM
Genes and Signals in Immune Regulation
Room: Peaks 1-5

Speaker 1 of 3
* Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
TIM Family of Genes: Role in T Cell Differentiation, Autoimmunity and Tolerance

Wednesday, March 22 | 5:00PM - 6:30PM
Genes and Signals in Immune Regulation
Room: Peaks 1-5

Speaker 2 of 3
Doron Melamed, Technion, Faculty of Medicine, Israel
Short Talk: Activation Competence of Developing Bone Marrow B Cells is a Novel Pathway for Initiation of B Cell Autoimmunity

Wednesday, March 22 | 5:00PM - 6:30PM
Genes and Signals in Immune Regulation
Room: Peaks 1-5

Speaker 3 of 3
Dale T. Umetsu, Genentech, Inc., USA
TIM-1, Hygiene and Allergic Disease

Wednesday, March 22 | 6:30PM - 7:30PM
Social Hour with Lite Bites
Room: Peaks 14-17


Wednesday, March 22 | 7:00PM - 10:00PM
Poster Session 1
Room: Peaks 14-17


Wednesday, March 22 | 8:00PM - 9:30PM
Workshop A: Apoptosis vs. Anergy Signals in Tolerance
Room: Peaks 1-4

Speaker 1 of 11
* Richard M. Siegel, NIAMS, National Institutes of Health, USA

Wednesday, March 22 | 8:00PM - 9:30PM
Workshop A: Apoptosis vs. Anergy Signals in Tolerance
Room: Peaks 1-4

Speaker 2 of 11
* Jonathan D. Powell, Johns Hopkins University School of Medicine, USA

Wednesday, March 22 | 8:00PM - 9:30PM
Workshop A: Apoptosis vs. Anergy Signals in Tolerance
Room: Peaks 1-4

Speaker 3 of 11
Georgia Fousteri, University of Crete, Greece
A Novel in vivo Role of TNF on Peripheral CD8 T Cell Tolerance: TNF Deficiency Leads to Development of Autoimmune Diabetes in a TCR/Antigen Mouse Model

Wednesday, March 22 | 8:00PM - 9:30PM
Workshop A: Apoptosis vs. Anergy Signals in Tolerance
Room: Peaks 1-4

Speaker 4 of 11
Brian T. Fife, University of Minnesota, USA
The Programmed Death-1 (PD-1) Pathway Regulates the Induction and Maintenance of Peripheral T Cell Tolerance during Autoimmune Diabetes in Nonobese Diabetic (NOD) Mice

Wednesday, March 22 | 8:00PM - 9:30PM
Workshop A: Apoptosis vs. Anergy Signals in Tolerance
Room: Peaks 1-4

Speaker 5 of 11
Paul E. Zarek, Johns Hopkins University, USA
A2a Receptor Engagement on T Cells Promotes T Cell Tolerance

Wednesday, March 22 | 8:00PM - 9:30PM
Workshop A: Apoptosis vs. Anergy Signals in Tolerance
Room: Peaks 1-4

Speaker 6 of 11
Nikolay P. Nikolov, National Institutes of Health, USA
Autoimmunity and Impaired T Cell Apoptosis in Wiskott-Aldrich Syndrome Protein Deficiency: A FasL Connection

Wednesday, March 22 | 8:00PM - 9:30PM
Workshop A: Apoptosis vs. Anergy Signals in Tolerance
Room: Peaks 1-4

Speaker 7 of 11
Carrie D. Beal, Cleveland Clinic Foundation, USA
SHP-1 Regulates Anergy Induction in Autoimmune T Cells in Experimental Autoimmune Encephalomyelitis

Wednesday, March 22 | 8:00PM - 9:30PM
Workshop A: Apoptosis vs. Anergy Signals in Tolerance
Room: Peaks 1-4

Speaker 8 of 11
Shiang-Jong Tzeng, National Taiwan University, Taiwan
C-Abl Family Kinases Mediate Apoptosis in B Cells in Response to Fc Receptor Stimulation

Wednesday, March 22 | 8:00PM - 9:30PM
Workshop A: Apoptosis vs. Anergy Signals in Tolerance
Room: Peaks 1-4

Speaker 9 of 11
Yuanyuan Zha, University of Chicago, USA
Established T Cell Anergy is Reversed by Active Ras and Partially Regulated by Diacylglycerol Kinase

Wednesday, March 22 | 8:00PM - 9:30PM
Workshop A: Apoptosis vs. Anergy Signals in Tolerance
Room: Peaks 1-4

Speaker 10 of 11
Jonathan A. Lindquist, Otto-von-Guericke University, Germany
Signaling in Anergy: From Fyn to PAG to Ras

Wednesday, March 22 | 8:00PM - 9:30PM
Workshop A: Apoptosis vs. Anergy Signals in Tolerance
Room: Peaks 1-4

Speaker 11 of 11
Fernando Macian, Albert Einstein College of Medicine, USA
Active Transcriptional Repression Controls IL-2 Expression in Anergic T Cells

Wednesday, March 22 | 8:00PM - 9:30PM
Workshop B: How Many Suppressors Are There?
Room: Peak 5

Speaker 1 of 11
* Rachel R. Caspi, NEI, National Institutes of Health, USA

Wednesday, March 22 | 8:00PM - 9:30PM
Workshop B: How Many Suppressors Are There?
Room: Peak 5

Speaker 2 of 11
Danielle M. Nast, University of Missouri, USA
Loss of Membrane-Bound TGFbeta during the Onset of Insulitis Disables Treg Function Leading to Diabetes

Wednesday, March 22 | 8:00PM - 9:30PM
Workshop B: How Many Suppressors Are There?
Room: Peak 5

Speaker 3 of 11
Geoffrey L. Stephens, Cellcion, LLC, USA
A Distinct Subset of MHC-Independent FoxP3+ T Cells Participates in the Control of Adaptive Immune Responses in vivo

Wednesday, March 22 | 8:00PM - 9:30PM
Workshop B: How Many Suppressors Are There?
Room: Peak 5

Speaker 4 of 11
Mindi R. Walker, Johnson and Johnson, USA
Generation of Autoantigen-Specific CD4+CD25+ Regulatory T Cells from Human CD4+CD25- Cells

Wednesday, March 22 | 8:00PM - 9:30PM
Workshop B: How Many Suppressors Are There?
Room: Peak 5

Speaker 5 of 11
Vanessa A.G. Oliveira, Instituto de Medicina Molecular, Portugal
CD62L+CD25+CD4+ Regulatory T Cells Generated in vitro by Anti-CD4 Treatment Express FoxP3 and Can Prevent Rejection of Allogeneic Skin Transplants

Wednesday, March 22 | 8:00PM - 9:30PM
Workshop B: How Many Suppressors Are There?
Room: Peak 5

Speaker 6 of 11
Judith A. Kapp, University of Alabama at Birmingham, USA
TCR Transgenic CD8+ T Cells Activated in the Presence of TGFbeta1 Express FoxP3 and Mediate Linked-Suppression of MLR Responses and Cardiac Rejection

Wednesday, March 22 | 8:00PM - 9:30PM
Workshop B: How Many Suppressors Are There?
Room: Peak 5

Speaker 7 of 11
Sylvain Fisson, University of Evry Val d'Essonne, France
Therapeutic Potential of Self Antigen-Specific CD4+CD25+ Regulatory T Cells Selected in vitro from a Polyclonal Repertoire

Wednesday, March 22 | 8:00PM - 9:30PM
Workshop B: How Many Suppressors Are There?
Room: Peak 5

Speaker 8 of 11
Richard J. DiPaolo, NIAID, National Institutes of Health, USA
Polyclonal and Organ Specific CD4+CD25+Foxp3+ Regulatory
T Cells (nTregs): Different Mechanisms of Suppressing Organ Specific Autoimmunity in vivo


Wednesday, March 22 | 8:00PM - 9:30PM
Workshop B: How Many Suppressors Are There?
Room: Peak 5

Speaker 9 of 11
Rafael S. Grajewski, National Eye Institute, National Institutes of Health, USA
Endogenous Expression of IRBP is Dispensable for Generation of CD4+CD25+ Regulatory T Cells that Protect against IRBP-Induced Experimental Autoimmune Uveitis (EAU)

Wednesday, March 22 | 8:00PM - 9:30PM
Workshop B: How Many Suppressors Are There?
Room: Peak 5

Speaker 10 of 11
Yuelei Shen, New York University School of Medicine, USA
Depletion of FoxP3+ Regulatory T Cells Enhances Primary CD8 T Cell Responses, but Impairs Generation of Memory T Cells

Wednesday, March 22 | 8:00PM - 9:30PM
Workshop B: How Many Suppressors Are There?
Room: Peak 5

Speaker 11 of 11
Santiago Pablo Zelenay, Cancer Research UK, London Research Institute, UK
Regulatory T Cells Control Early Innate Immune Responses

Thursday, March 23 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Thursday, March 23 | 8:00AM - 12:00PM
Extrinsic Triggers and Intrinsic Drivers of Autoimmunity
Room: Peaks 1-5

Speaker 1 of 6
* Matthias G. von Herrath, Novo Nordisk and La Jolla Institute for Allergy and Immunology, USA
A Novel Combinatorial Treatment of Recent-Onset Type 1 Diabetes: Synergy between Islet-Antigen Specific Tregs and Non-Mitogenic Anti-CD3

Thursday, March 23 | 8:00AM - 12:00PM
Extrinsic Triggers and Intrinsic Drivers of Autoimmunity
Room: Peaks 1-5

Speaker 2 of 6
Joan Goverman, University of Washington, USA
The Dynamic State of Peripheral Tolerance In Myelin Basic Protein-Specific T Cells

Thursday, March 23 | 8:00AM - 12:00PM
Extrinsic Triggers and Intrinsic Drivers of Autoimmunity
Room: Peaks 1-5

Speaker 3 of 6
Daniel J. Cua, Janssen Pharmaceutical Companies of Johnson & Johnson, USA
Role of IL-23 in Autoimmune Disease Pathogenesis

Thursday, March 23 | 8:00AM - 12:00PM
Extrinsic Triggers and Intrinsic Drivers of Autoimmunity
Room: Peaks 1-5

Speaker 4 of 6
Silvia Bolland, NIAID, National Institutes of Health, USA
Short Talk: TLR7/8 Gene Duplication in the Pseudoautosomal Region of Y-Linked Autoimmune Accelerating (Yaa) Mice

Thursday, March 23 | 8:00AM - 12:00PM
Extrinsic Triggers and Intrinsic Drivers of Autoimmunity
Room: Peaks 1-5

Speaker 5 of 6
Stephen D. Miller, Northwestern University Medical School, USA
Epitope Spreading in Relapsing EAE: The CNS as a Neo-lymphoid Organ

Thursday, March 23 | 8:00AM - 12:00PM
Extrinsic Triggers and Intrinsic Drivers of Autoimmunity
Room: Peaks 1-5

Speaker 6 of 6
Pamela S. Ohashi, Princess Margaret Cancer Centre, Canada
Role of Apoptosis in the Induction of Tolerance versus Autoimmunity

Thursday, March 23 | 9:40AM - 10:00AM
Coffee Break
Room: Foyer


Thursday, March 23 | 12:00PM - 1:00PM
Poster Setup
Room: Peaks 14-17


Thursday, March 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 14-17


Thursday, March 23 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, March 23 | 5:00PM - 6:30PM
Extrinsic Triggers and Intrinsic Drivers of Autoimmunity
Room: Peaks 1-5

Speaker 1 of 4
* Terry L. Delovitch, John P. Robarts Research Institute and University of Western Ontario, Canada

Thursday, March 23 | 5:00PM - 6:30PM
Extrinsic Triggers and Intrinsic Drivers of Autoimmunity
Room: Peaks 1-5

Speaker 2 of 4
Brigitta Stockinger, Francis Crick Institute, UK
Homeostasis,Competition and Regulation of the Peripheral T Cell Pool

Thursday, March 23 | 5:00PM - 6:30PM
Extrinsic Triggers and Intrinsic Drivers of Autoimmunity
Room: Peaks 1-5

Speaker 3 of 4
Anne Cooke, University of Cambridge, UK
Perturbing the Balance Between Infection and Immunity: Consequences for Autoimmunity

Thursday, March 23 | 5:00PM - 6:30PM
Extrinsic Triggers and Intrinsic Drivers of Autoimmunity
Room: Peaks 1-5

Speaker 4 of 4
Mark J. Shlomchik, University of Pittsburgh School of Medicine, USA
Short Talk: Toll Like Receptors Control Autoantibody Specificities and Regulate Systemic Autoimmunity

Thursday, March 23 | 6:30PM - 7:30PM
Social Hour with Lite Bites
Room: Peaks 14-17


Thursday, March 23 | 7:00PM - 10:00PM
Poster Session 2
Room: Peaks 14-17


Thursday, March 23 | 8:00PM - 9:30PM
Town Hall Debate - Friendly or Dangerous Signals?
Room: Peaks 1-5

Speaker 1 of 5
* Matthias G. von Herrath, Novo Nordisk and La Jolla Institute for Allergy and Immunology, USA

Thursday, March 23 | 8:00PM - 9:30PM
Town Hall Debate - Friendly or Dangerous Signals?
Room: Peaks 1-5

Speaker 2 of 5
Polly Matzinger, NIAID, National Institutes of Health, USA

Thursday, March 23 | 8:00PM - 9:30PM
Town Hall Debate - Friendly or Dangerous Signals?
Room: Peaks 1-5

Speaker 3 of 5
Eyal Raz, University of California, San Diego, USA

Thursday, March 23 | 8:00PM - 9:30PM
Town Hall Debate - Friendly or Dangerous Signals?
Room: Peaks 1-5

Speaker 4 of 5
Neil S. Greenspan, Case Western Reserve University, USA

Thursday, March 23 | 8:00PM - 9:30PM
Town Hall Debate - Friendly or Dangerous Signals?
Room: Peaks 1-5

Speaker 5 of 5
Rolf M. Zinkernagel, University Hospital Zurich, Switzerland
Credo 2006

Friday, March 24 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Friday, March 24 | 8:00AM - 12:00PM
Suppression and Regulation of the Immune Response
Room: Peaks 1-5

Speaker 1 of 6
Terry L. Delovitch, John P. Robarts Research Institute and University of Western Ontario, Canada
Regulation of Type 1 Diabetes by iNKT Cells, Cytokines and Chemokines

Friday, March 24 | 8:00AM - 12:00PM
Suppression and Regulation of the Immune Response
Room: Peaks 1-5

Speaker 2 of 6
* Rachel R. Caspi, NEI, National Institutes of Health, USA
Generation of Pathogenic and Regulatory T Cells in a Model of Retinal Autoimmunity: Dependency on Innate Immune Responses

Friday, March 24 | 8:00AM - 12:00PM
Suppression and Regulation of the Immune Response
Room: Peaks 1-5

Speaker 3 of 6
Joan Stein-Streilein, Schepens Eye Research Institute, USA
Privilege, Deviation and Regulatory Cell Circuits: Assembling the Puzzle

Friday, March 24 | 8:00AM - 12:00PM
Suppression and Regulation of the Immune Response
Room: Peaks 1-5

Speaker 4 of 6
Michele M. Kosiewicz, University of Louisville, USA
Short Talk: Androgen-Driven Expression of CD103 by CD4+CD25+ Regulatory Cells is Associated with Increased Regulatory Function and Prevention of Autoimmune Disease

Friday, March 24 | 8:00AM - 12:00PM
Suppression and Regulation of the Immune Response
Room: Peaks 1-5

Speaker 5 of 6
Habib Zaghouani, University of Missouri School of Medicine, USA
Tregs For or Against Autoimmunity

Friday, March 24 | 8:00AM - 12:00PM
Suppression and Regulation of the Immune Response
Room: Peaks 1-5

Speaker 6 of 6
Andrew L. Mellor, Georgia Regents University, USA
Regulation of T Cell Responses by Indoleamine 2,3 Dioxygenase (IDO)

Friday, March 24 | 9:40AM - 10:00AM
Coffee Break
Room: Foyer


Friday, March 24 | 12:00PM - 1:00PM
Poster Setup
Room: Peaks 14-17


Friday, March 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 14-17


Friday, March 24 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Friday, March 24 | 5:00PM - 6:30PM
Suppression and Regulation of the Immune Response
Room: Peaks 1-5

Speaker 1 of 4
* Anne Cooke, University of Cambridge, UK

Friday, March 24 | 5:00PM - 6:30PM
Suppression and Regulation of the Immune Response
Room: Peaks 1-5

Speaker 2 of 4
Shimon Sakaguchi, Osaka University, Japan
Natural Tregs and Autoimmune Diseases

Friday, March 24 | 5:00PM - 6:30PM
Suppression and Regulation of the Immune Response
Room: Peaks 1-5

Speaker 3 of 4
Joshua D. Milner, Columbia University, USA
Short Talk: Reconstitution of Lymphopenic Mice with Limited T-Cell Repertoire Results in Severe Multiorgan Eosinophilic Disease

Friday, March 24 | 5:00PM - 6:30PM
Suppression and Regulation of the Immune Response
Room: Peaks 1-5

Speaker 4 of 4
Kathryn J. Wood, University of Oxford, UK
Transplantation Tolerance - Control of Rejection by Alloantigen Reactive Regulatory T Cells

Friday, March 24 | 6:30PM - 7:30PM
Social Hour with Lite Bites
Room: Peaks 14-17


Friday, March 24 | 7:00PM - 10:00PM
Poster Session 3
Room: Peaks 14-17


Friday, March 24 | 8:00PM - 9:30PM
Workshop C: Genetics of Autoimmunity
Room: Peaks 1-4

Speaker 1 of 7
* Jayne S. Danska, Hospital for Sick Children Research Institute, Canada
Genomic Analysis of the NOD Idd4 Locus in Type 1 Diabetes: Candidate Genes and Complex Genetic Architecture

Friday, March 24 | 8:00PM - 9:30PM
Workshop C: Genetics of Autoimmunity
Room: Peaks 1-4

Speaker 2 of 7
* Bhagirath Singh, University of Western Ontario, Canada

Friday, March 24 | 8:00PM - 9:30PM
Workshop C: Genetics of Autoimmunity
Room: Peaks 1-4

Speaker 3 of 7
Stephan Kissler, Joslin Diabetes Center, USA
In vivo RNA Interference Demonstrates Nramp1 is a Type 1 Diabetes Gene

Friday, March 24 | 8:00PM - 9:30PM
Workshop C: Genetics of Autoimmunity
Room: Peaks 1-4

Speaker 4 of 7
Mehmet L. Guler, Johns Hopkins University, USA
Two Autoimmune Disease Loci Influencing T Cell Apoptosis Control Susceptibility to Experimental Autoimmune Myocarditis

Friday, March 24 | 8:00PM - 9:30PM
Workshop C: Genetics of Autoimmunity
Room: Peaks 1-4

Speaker 5 of 7
Robert H. Wallis, Sunnybrook & Women's College Health Sciences Centre, Canada
A Novel Type 1 Diabetes Susceptibility Locus Identified Using the BB/WOR Rat Model

Friday, March 24 | 8:00PM - 9:30PM
Workshop C: Genetics of Autoimmunity
Room: Peaks 1-4

Speaker 6 of 7
Zhibin Chen, University of Miami, USA
Modeling CTLA-4-Associated Human Autoimmune Diseases with Transgenic RNA Interference in Mice

Friday, March 24 | 8:00PM - 9:30PM
Workshop C: Genetics of Autoimmunity
Room: Peaks 1-4

Speaker 7 of 7
Emma E. Hamilton-Williams, University of Queensland, Australia
Loss of CD8 Self-Tolerance in the NOD Mouse is Controlled by Genes Encoded Within the Idd9 Locus

Friday, March 24 | 8:00PM - 9:30PM
Workshop D: Novel Therapies for Tolerance
Room: Peak 5

Speaker 1 of 14
* David W. Scott, Uniformed Services University of Health Sciences, USA

Friday, March 24 | 8:00PM - 9:30PM
Workshop D: Novel Therapies for Tolerance
Room: Peak 5

Speaker 2 of 14
* Anne Cooke, University of Cambridge, UK

Friday, March 24 | 8:00PM - 9:30PM
Workshop D: Novel Therapies for Tolerance
Room: Peak 5

Speaker 3 of 14
Howard L. Weiner, Brigham and Women’s Hospital, Harvard Medical School, USA
Mucosal Anti-CD3 Antibody Suppresses EAE, Collagen Crthritis, Diabetes and Prolongs Cardiac Allograft Survival by Inducing CD4+CD25-LAP+ Regulatory T Cells

Friday, March 24 | 8:00PM - 9:30PM
Workshop D: Novel Therapies for Tolerance
Room: Peak 5

Speaker 4 of 14
Claudia Mauri, University College London, UK
Anti TNF-alpha Therapy in Rheumatoid Arthritis Promotes the Differentiation of Regulatory T Cells with a Memory-Like Phenotype

Friday, March 24 | 8:00PM - 9:30PM
Workshop D: Novel Therapies for Tolerance
Room: Peak 5

Speaker 5 of 14
Sayuri Yamazaki, Rockefeller University, USA
Effective Expansion of Alloantigen-Specific Foxp3+ CD25+ CD4+ Regulatory T Cells by Dendritic Cells during the Mixed Leukocyte Reaction

Friday, March 24 | 8:00PM - 9:30PM
Workshop D: Novel Therapies for Tolerance
Room: Peak 5

Speaker 6 of 14
David J. Kahler, Medical College of Georgia, USA
Type I Interferon Mediates T Cell Suppression By Inducing Indoleamine 2,3 Dioxygenase Expression in Dendritic Cells

Friday, March 24 | 8:00PM - 9:30PM
Workshop D: Novel Therapies for Tolerance
Room: Peak 5

Speaker 7 of 14
Ivan Zanoni, University of Milano Bicocca, Italy
Induction of Peripheral T Cell Tolerance by Antigen Presenting B Cells: The Activation state of Antigen Presenting Cells is Not Relevant for Tolerization when the Antigen is Chronically Presented

Friday, March 24 | 8:00PM - 9:30PM
Workshop D: Novel Therapies for Tolerance
Room: Peak 5

Speaker 8 of 14
Manuela Battaglia, TIGET, Telethon Institute for Gene Therapy, Italy
Rapamycin Promotes Expansion of CD4+CD25+ Tr Cells from NOD Mice

Friday, March 24 | 8:00PM - 9:30PM
Workshop D: Novel Therapies for Tolerance
Room: Peak 5

Speaker 9 of 14
Alan R. Anderson, USA
Significant Expansion and Suppressive Function of Rhesus Macaque Regulatory T Cells

Friday, March 24 | 8:00PM - 9:30PM
Workshop D: Novel Therapies for Tolerance
Room: Peak 5

Speaker 10 of 14
Sarah E. Allan, Elsevier, UK
Generation of Human T Regulatory Cells by FOXP3 Transduction in vitro

Friday, March 24 | 8:00PM - 9:30PM
Workshop D: Novel Therapies for Tolerance
Room: Peak 5

Speaker 11 of 14
Carsten Wiethe, University of Erlangen, Germany
Interdependency of MHC II/Self-Peptide and CD1D/Self-IGB3 Presentation for Autoimmune Disease Protection Induced by TNF-Stimulated Dendritic Cells

Friday, March 24 | 8:00PM - 9:30PM
Workshop D: Novel Therapies for Tolerance
Room: Peak 5

Speaker 12 of 14
Andre I. David, University of Miami, USA
Bone Marrow Derived Mesenchymal Cells Delay Allogeneic Rejection

Friday, March 24 | 8:00PM - 9:30PM
Workshop D: Novel Therapies for Tolerance
Room: Peak 5

Speaker 13 of 14
Ehud Hauben, San Raffaele Hospital, Italy
A Novel Low Molecular Weight Compound Promotes Islets Allograft Acceptance and Induces Long-Term Active Tolerance

Friday, March 24 | 8:00PM - 9:30PM
Workshop D: Novel Therapies for Tolerance
Room: Peak 5

Speaker 14 of 14
Michael R. Ehrenstein, University College London, UK
B Cell Depletion for Autoimmunity

Saturday, March 25 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Saturday, March 25 | 8:00AM - 12:00PM
Translating Tolerance to the Clinic
Room: Peaks 1-5

Speaker 1 of 6
* David W. Scott, Uniformed Services University of Health Sciences, USA
B-Cell Induced Tolerance for Autoimmunity and Hemophilia

Saturday, March 25 | 8:00AM - 12:00PM
Translating Tolerance to the Clinic
Room: Peaks 1-5

Speaker 2 of 6
Jean-Marie Saint-Remy, University of Leuven, Belgium
Cytolytic regulatory T cells in experimental allergic asthma

Saturday, March 25 | 8:00AM - 12:00PM
Translating Tolerance to the Clinic
Room: Peaks 1-5

Speaker 3 of 6
Lucienne Chatenoud, INSERM U1151, Hôpital Necker-Enfants Malades, France
Treatment of Type 1 Diabetes by Restoration of Self-Tolerance

Saturday, March 25 | 8:00AM - 12:00PM
Translating Tolerance to the Clinic
Room: Peaks 1-5

Speaker 4 of 6
David H. Wagner, Jr., University of Colorado Health Sciences Center, USA
Short Talk: Of Mice and Man: Identification of Auto-Aggressor T Cells and Breach of Self-Tolerance in Type 1 Diabetes

Saturday, March 25 | 8:00AM - 12:00PM
Translating Tolerance to the Clinic
Room: Peaks 1-5

Speaker 5 of 6
Clare M. Baecher-Allan, Brigham and Women's Hospital, Harvard Medical School, USA
Short Talk: Functionally Distinct Subsets of Human Natural Regulatory T cells

Saturday, March 25 | 8:00AM - 12:00PM
Translating Tolerance to the Clinic
Room: Peaks 1-5

Speaker 6 of 6
Maria Grazia Roncarolo, Stanford University School of Medicine, USA
Human Suppressor T Cells in Clinical Application

Saturday, March 25 | 9:40AM - 10:00AM
Coffee Break
Room: Foyer


Saturday, March 25 | 12:00PM - 1:00PM
Lunch
Room: Peaks 14-17


Saturday, March 25 | 12:00PM - 1:00PM
Poster Setup
Room: Peaks 14-17


Saturday, March 25 | 1:00PM - 5:00PM
Poster Viewing


Saturday, March 25 | 1:00PM - 3:00PM
Poster Session 4
Room: Peaks 14-17


Saturday, March 25 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Saturday, March 25 | 5:00PM - 6:00PM
Translating Tolerance to the Clinic
Room: Peaks 1-5

Speaker 1 of 4
* David W. Scott, Uniformed Services University of Health Sciences, USA

Saturday, March 25 | 5:00PM - 6:00PM
Translating Tolerance to the Clinic
Room: Peaks 1-5

Speaker 2 of 4
* Rachel R. Caspi, NEI, National Institutes of Health, USA

Saturday, March 25 | 5:00PM - 6:00PM
Translating Tolerance to the Clinic
Room: Peaks 1-5

Speaker 3 of 4
Sergio A. Quezada, University College London, UK
Short Talk: CTLA-4 Blockade and GMCSF Combination Immunotherapy Alters the Intra-Tumor Balance of Effector and Regulatory T Cells Without Directly Interfering with Regulatory T Cell Activity

Saturday, March 25 | 5:00PM - 6:00PM
Translating Tolerance to the Clinic
Room: Peaks 1-5

Speaker 4 of 4
Jeffrey A. Bluestone, University of California, San Francisco, USA
Intrinsic and Extrinsic Regulation of Autoimmune Diabetes

Saturday, March 25 | 6:00PM - 7:00PM
Lifetime Achievement Awards
Room: Peaks 1-5

Speaker 1 of 2
Eli E. Sercarz, Torrey Pines Institute for Molecular Studies, USA
Repertoires, Drivers and Passengers in a Lifetime Sojourn

Saturday, March 25 | 6:00PM - 7:00PM
Lifetime Achievement Awards
Room: Peaks 1-5

Speaker 2 of 2
Noel R. Rose, Johns Hopkins University, USA
Environmental Triggers of Autoimmunity: We’ve Come to This!

Saturday, March 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 14-17


Saturday, March 25 | 8:00PM - 11:00PM
Entertainment
Room: Peaks 14-17


Saturday, March 25 | 8:00PM - 11:00PM
Cash Bar
Room: Peaks 14-17


Sunday, March 26 | 10:26AM - 10:26AM
Departure


*Session Chair.