Web Desc
Lipid Rafts and Cell Function
Organizer(s): Linda J. Pike and Michael A. Edidin
Date: March 23 - 28, 2006
Location: Sheraton Steamboat Resort, Steamboat Springs, Colorado, USA
Supported by The Director's Fund
For important information on the coronavirus, please click here
Summary of Meeting:
Lipid rafts are membrane microdomains that are enriched in cholesterol and glycosphingolipids. They were originally implicated in lipid trafficking, but now appear to be involved in a plethora of biological processes including signal transduction, endocytosis and protein and lipid sorting. Studies of lipid rafts have been hampered by the lack of appropriate methods to analyze them in intact cells and an insufficient understanding of their mechanism of formation and biological function within cells. This conference will examine several important issues related to the structure and function of lipid rafts including: i) biophysical and biochemical methods for the visualization and analysis of lipid rafts; ii) biogenesis of rafts and their size; iii) the role of rafts in signal transduction.; and, iv) the role of rafts in endocytosis and protein processing.
Scholarship Deadline: November 22 2005
Discounted Abstract Deadline: November 22 2005
Abstract Deadline: December 16 2005
Discounted Registration Deadline: January 23 2006
We gratefully acknowledge additional support for this conference from:
Novartis Institutes for BioMedical Research
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

EMBO Young Investigator Programme
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of General Medical Sciences (NIGMS)
Grant No. 1R13 GM076901-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Thursday, March 23 | 3:00PM - 7:30PM
Registration
Room: Foyer


Thursday, March 23 | 6:30PM - 7:30PM
Refreshments
Room: Foyer


Thursday, March 23 | 7:30PM - 8:30PM
Keynote Address
Room: Storm Peak / Mt. Werner

Speaker 1 of 1
Ari Helenius, ETH Zurich, Switzerland
The Role of Membrane Domains in Animal Virus Entry

Friday, March 24 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles / Bear River


Friday, March 24 | 8:00AM - 11:00AM
Biophysics of Lipid Domains I
Room: Storm Peak / Mt. Werner

Speaker 1 of 5
Sarah L. Veatch, USA
Complex Phase Behavior in ‘Simple’ Membranes

Friday, March 24 | 8:00AM - 11:00AM
Biophysics of Lipid Domains I
Room: Storm Peak / Mt. Werner

Speaker 2 of 5
John R. Silvius, McGill University, Canada
Physical Studies of Domains in Model and Biological Membranes

Friday, March 24 | 8:00AM - 11:00AM
Biophysics of Lipid Domains I
Room: Storm Peak / Mt. Werner

Speaker 3 of 5
Stuart G. McLaughlin, Stony Brook University, USA
PIP2, Proteins, and Lipid Rafts

Friday, March 24 | 8:00AM - 11:00AM
Biophysics of Lipid Domains I
Room: Storm Peak / Mt. Werner

Speaker 4 of 5
* Ken Jacobson, University of North Carolina at Chapel Hill, USA
Nanoscale Signal Transduction Across the Plasma Membrane


Friday, March 24 | 8:00AM - 11:00AM
Biophysics of Lipid Domains I
Room: Storm Peak / Mt. Werner

Speaker 5 of 5
Luana Lea Scheffer, Weizmann Institute of Science, Israel
Short Talk: Antibody Detection of Plasma Membrane Domains Enriched in Ceramide and Cholesterol

Friday, March 24 | 9:20AM - 9:40AM
Coffee Break
Room: Sunshine


Friday, March 24 | 11:00AM - 1:00PM
Poster Setup
Room: Sunshine


Friday, March 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunshine


Friday, March 24 | 4:30PM - 5:00PM
Coffee Available
Room: Sunshine


Friday, March 24 | 5:00PM - 7:00PM
Biophysics of Lipid Domains II
Room: Storm Peak / Mt. Werner

Speaker 1 of 4
Satyajit Mayor, National Centre for Biological Sciences, India
Size of Lipid Rafts in vivo: Lessons from Examining Segregation of GPI-Anchored Proteins in Membranes of Living Cells

Friday, March 24 | 5:00PM - 7:00PM
Biophysics of Lipid Domains II
Room: Storm Peak / Mt. Werner

Speaker 2 of 4
Anne K. Kenworthy, USA
Raft Dynamics: Chasing a Moving Target

Friday, March 24 | 5:00PM - 7:00PM
Biophysics of Lipid Domains II
Room: Storm Peak / Mt. Werner

Speaker 3 of 4
* Barbara A. Baird, Cornell University, USA
Lipid Segregation and Plasma Membrane Interactions Related to IgE-Receptor Signaling

Friday, March 24 | 5:00PM - 7:00PM
Biophysics of Lipid Domains II
Room: Storm Peak / Mt. Werner

Speaker 4 of 4
Fabien Pinaud, USA
Short Talk: In & Out of Lipid Rafts: A Quantum Dot View of the Cell Membrane Structure

Friday, March 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Foyer


Friday, March 24 | 7:30PM - 10:00PM
Poster Session 1
Room: Sunshine


Saturday, March 25 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles / Bear River


Saturday, March 25 | 8:00AM - 11:00AM
Rafts and Cell Signaling
Room: Storm Peak / Mt. Werner

Speaker 1 of 5
* Paul A. Insel, University of California, San Diego, USA
Lipid Rafts in Signaling via Adenylyl Cyclase

Saturday, March 25 | 8:00AM - 11:00AM
Rafts and Cell Signaling
Room: Storm Peak / Mt. Werner

Speaker 2 of 5
James Alan Shayman, University of Michigan, USA
Using Small Molecule Inhibitors to Study the Role of Glycosphingolipids in the Regulation of Phospholipase C

Saturday, March 25 | 8:00AM - 11:00AM
Rafts and Cell Signaling
Room: Storm Peak / Mt. Werner

Speaker 3 of 5
Jeffrey E. Pessin, Albert Einstein College of Medicine, USA
Insulin Receptor Signaling in Fyn Knockout Mice

Saturday, March 25 | 8:00AM - 11:00AM
Rafts and Cell Signaling
Room: Storm Peak / Mt. Werner

Speaker 4 of 5
Linda J. Pike, Washington University School of Medicine, USA
Cholesterol-dependent Clustering of the EGF Receptor Investigated in Live Cells by Fluorescence Cluster Analysis

Saturday, March 25 | 8:00AM - 11:00AM
Rafts and Cell Signaling
Room: Storm Peak / Mt. Werner

Speaker 5 of 5
Erik Hofman, University of Utrecht, Netherlands
Short Talk: EGF Receptor Colocalization with Gangliosides during Signalling

Saturday, March 25 | 9:20AM - 9:40AM
Coffee Break
Room: Sunshine


Saturday, March 25 | 11:00AM - 1:00PM
Poster Setup
Room: Sunshine


Saturday, March 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunshine


Saturday, March 25 | 2:30PM - 4:30PM
Workshop: Visualizing Membrane Domains: The Size of Lipid Ra
fts
Room: Storm Peak / Mt. Werner

Speaker 1 of 8
* Michael A. Edidin, Johns Hopkins School of Medicine, USA

Saturday, March 25 | 2:30PM - 4:30PM
Workshop: Visualizing Membrane Domains: The Size of Lipid Ra
fts
Room: Storm Peak / Mt. Werner

Speaker 2 of 8
Toyoshi Fujimoto, Nagoya University Graduate School of Medicine, Japan
Immunoelectron Microscopy of Quick-Frozen and Freeze-Fractured Membranes Revealed Heterogeneous GM1 and GM3 Microdomains in the Cell Membrane

Saturday, March 25 | 2:30PM - 4:30PM
Workshop: Visualizing Membrane Domains: The Size of Lipid Ra
fts
Room: Storm Peak / Mt. Werner

Speaker 3 of 8
Alan R. Burns, Sandia National Laboratories, USA
Probing Domains in the Inner Plasma Membrane with Simultaneous Atomic Force Microscopy and Fluorescence Imaging

Saturday, March 25 | 2:30PM - 4:30PM
Workshop: Visualizing Membrane Domains: The Size of Lipid Ra
fts
Room: Storm Peak / Mt. Werner

Speaker 4 of 8
Anil Bamezai, Villanova University, USA
Role of a â2 Integrin in Spatial Organization of Cholesterol-Rich Microdomains on CD4+ T Cell Plasma Membrane during T Cell-Antigen Presenting Cell Interaction

Saturday, March 25 | 2:30PM - 4:30PM
Workshop: Visualizing Membrane Domains: The Size of Lipid Ra
fts
Room: Storm Peak / Mt. Werner

Speaker 5 of 8
Mika Ruonala, Center for Membrane Proteomics, Germany
The Segregation and Aggregation of Lipid Microdomains during Cytoskeletal Reorganization

Saturday, March 25 | 2:30PM - 4:30PM
Workshop: Visualizing Membrane Domains: The Size of Lipid Ra
fts
Room: Storm Peak / Mt. Werner

Speaker 6 of 8
John F. Hancock, University of Texas Health Science Center, USA

Saturday, March 25 | 2:30PM - 4:30PM
Workshop: Visualizing Membrane Domains: The Size of Lipid Ra
fts
Room: Storm Peak / Mt. Werner

Speaker 7 of 8
Satyajit Mayor, National Centre for Biological Sciences, India

Saturday, March 25 | 2:30PM - 4:30PM
Workshop: Visualizing Membrane Domains: The Size of Lipid Ra
fts
Room: Storm Peak / Mt. Werner

Speaker 8 of 8
Ken Jacobson, University of North Carolina at Chapel Hill, USA

Saturday, March 25 | 4:30PM - 5:00PM
Coffee Available
Room: Sunshine


Saturday, March 25 | 5:00PM - 7:00PM
Targeting Proteins to Lipid Rafts
Room: Storm Peak / Mt. Werner

Speaker 1 of 4
John F. Hancock, University of Texas Health Science Center, USA
Ras Plasma Membrane Signaling Platforms

Saturday, March 25 | 5:00PM - 7:00PM
Targeting Proteins to Lipid Rafts
Room: Storm Peak / Mt. Werner

Speaker 2 of 4
Enrico Gratton, University of Illinois at Urbana Champaign, USA

Saturday, March 25 | 5:00PM - 7:00PM
Targeting Proteins to Lipid Rafts
Room: Storm Peak / Mt. Werner

Speaker 3 of 4
* Deborah A. Brown, Stony Brook University, USA
Non-Clathrin-Mediated Endocytosis of ErbB2 in Geldanamycin-Treated Human Breast Cancer Cells

Saturday, March 25 | 5:00PM - 7:00PM
Targeting Proteins to Lipid Rafts
Room: Storm Peak / Mt. Werner

Speaker 4 of 4
Natalie Bezman, Bristol-Myers Squibb Company, USA
Short Talk: Dissection of ITAM and Integrin Signaling Pathways in Hematopoietic Cells by Targeting SLP-76 to Lipid Rafts

Saturday, March 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Foyer


Saturday, March 25 | 7:30PM - 10:00PM
Poster Session 2
Room: Sunshine


Sunday, March 26 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles / Bear River


Sunday, March 26 | 8:00AM - 11:00AM
Rafts and Immune Signaling
Room: Storm Peak / Mt. Werner

Speaker 1 of 5
Daved Fremont, Washington University School of Medicine, USA
Structural Biology of Immunoreceptors

Sunday, March 26 | 8:00AM - 11:00AM
Rafts and Immune Signaling
Room: Storm Peak / Mt. Werner

Speaker 2 of 5
Antonella Viola, University of Milan, Italy
Lipid Rafts in Lymphocyte Activation

Sunday, March 26 | 8:00AM - 11:00AM
Rafts and Immune Signaling
Room: Storm Peak / Mt. Werner

Speaker 3 of 5
Anthony I. Magee, Imperial College London, UK
Lipid Rafts, Protein S-Acylation and Immune Cell Signaling

Sunday, March 26 | 8:00AM - 11:00AM
Rafts and Immune Signaling
Room: Storm Peak / Mt. Werner

Speaker 4 of 5
* Susan K. Pierce, NIAID, National Institutes of Health, USA
The Antigen-Induced Association of the B Cell Receptor with Lipid Rafts Visualized in Living Cells by FRET

Sunday, March 26 | 8:00AM - 11:00AM
Rafts and Immune Signaling
Room: Storm Peak / Mt. Werner

Speaker 5 of 5
Neetu Gupta, Cleveland Clinic, USA
Short Talk: A Role for Ezrin in the Regulation of Lipid Raft Dynamics During B Cell Activation

Sunday, March 26 | 9:20AM - 9:40AM
Coffee Break
Room: Sunshine


Sunday, March 26 | 11:00AM - 1:00PM
Poster Setup
Room: Sunshine


Sunday, March 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunshine


Sunday, March 26 | 4:30PM - 5:00PM
Coffee Available
Room: Sunshine


Sunday, March 26 | 5:00PM - 7:00PM
Processing of Protein in Lipid Rafts
Room: Storm Peak / Mt. Werner

Speaker 1 of 4
Albert Taraboulos, Hebrew University of Jerusalem, Israel
Prions and Lipid Rafts

Sunday, March 26 | 5:00PM - 7:00PM
Processing of Protein in Lipid Rafts
Room: Storm Peak / Mt. Werner

Speaker 2 of 4
Nicole Watt, University of Leeds, UK
Lipid Rafts in the Processing of the Amyloid Precursor Protein and Prion Protein

Sunday, March 26 | 5:00PM - 7:00PM
Processing of Protein in Lipid Rafts
Room: Storm Peak / Mt. Werner

Speaker 3 of 4
Gopal Thinakaran, University of Chicago, USA
Gamma-Secretase Localization and Processing of APP in Lipid Rafts

Sunday, March 26 | 5:00PM - 7:00PM
Processing of Protein in Lipid Rafts
Room: Storm Peak / Mt. Werner

Speaker 4 of 4
Alessandra Cambi, Max Planck Institute for Biophysical Chemistry, Germany
Short Talk: Application of Quantum Dots to Mimic Virus Binding and Uptake via Nanoclusters of the Pathogen Receptor DC-SIGN

Sunday, March 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Foyer


Sunday, March 26 | 7:30PM - 10:00PM
Poster Session 3
Room: Sunshine


Monday, March 27 | 7:00AM - 8:00AM
Breakfast
Room: 3 Saddles / Bear River


Monday, March 27 | 8:00AM - 11:00AM
Caveolin and the Targeting of Lipids
Room: Storm Peak / Mt. Werner

Speaker 1 of 5
* Richard G.W. Anderson, University of Texas Southwestern Medical Center, USA
Mechanism of Adiposome Biogenesis

Monday, March 27 | 8:00AM - 11:00AM
Caveolin and the Targeting of Lipids
Room: Storm Peak / Mt. Werner

Speaker 2 of 5
T.Y. Chang, Dartmouth Medical School, USA
Cholesterol Sensing, Trafficking and Esterification

Monday, March 27 | 8:00AM - 11:00AM
Caveolin and the Targeting of Lipids
Room: Storm Peak / Mt. Werner

Speaker 3 of 5
Cynthia Corley Mastick, University of Nevada, USA
Phosphorylation of Caveolin and Regulation of Src-Family Kinases by Csk

Monday, March 27 | 8:00AM - 11:00AM
Caveolin and the Targeting of Lipids
Room: Storm Peak / Mt. Werner

Speaker 4 of 5
Miguel A. del Pozo, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Spain
EMBO Young Investigator Lecture: Caveolin and Integrins in Internalization of Plasma Membrane Microdomains

Monday, March 27 | 8:00AM - 11:00AM
Caveolin and the Targeting of Lipids
Room: Storm Peak / Mt. Werner

Speaker 5 of 5
Paul F. Pilch, Boston University School of Medicine, USA
Short Talk: Caveolin-1/Cholesterol Modulates Transmembrane Fatty Acid Movement

Monday, March 27 | 9:20AM - 9:40AM
Coffee Break
Room: Sunshine


Monday, March 27 | 4:30PM - 5:00PM
Coffee Available
Room: Sunshine


Monday, March 27 | 5:00PM - 7:00PM
Endocytosis and Trafficking via Lipid Rafts
Room: Storm Peak / Mt. Werner

Speaker 1 of 4
* Eric O. Freed, NCI, National Institutes of Health, USA
Role of Lipid Microdomains in HIV-1 Replication

Monday, March 27 | 5:00PM - 7:00PM
Endocytosis and Trafficking via Lipid Rafts
Room: Storm Peak / Mt. Werner

Speaker 2 of 4
Joshua Zimmerberg, NICHD, National Institutes of Health, USA
Self-Assembly of the Influenza Hemagglutinin in the Plasma Membrane

Monday, March 27 | 5:00PM - 7:00PM
Endocytosis and Trafficking via Lipid Rafts
Room: Storm Peak / Mt. Werner

Speaker 3 of 4
Wayne Lencer, Children's Hospital Boston, USA
Retrograde Trafficking of Cholera Toxin by Lipid Raft Gangliosides

Monday, March 27 | 5:00PM - 7:00PM
Endocytosis and Trafficking via Lipid Rafts
Room: Storm Peak / Mt. Werner

Speaker 4 of 4
Amit Choudhury, Mayo Clinic, USA
Short Talk: Regulation of Caveolar Endocytosis by Syntaxin 6-Dependent Delivery of Membrane Components to the Cell Surface

Monday, March 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Foyer


Monday, March 27 | 8:00PM - 11:00PM
Entertainment
Room: Sunshine


Monday, March 27 | 8:00PM - 11:00PM
Cash Bar
Room: Sunshine


Tuesday, March 28 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.