Web Desc
NF-kappaB: 20 Years on the Road from Biochemistry to Pathology
Organizer(s): Alain Israël, David Baltimore and Yinon M. Ben-Neriah
Date: March 23 - 28, 2006
Location: Fairmont Banff Springs, Banff, AB, Canada
Supported by The Director's Fund
Summary of Meeting:
The NF-kB signaling pathway is a critical determinant of the inflammatory response, and is involved in both innate and acquired immunity. It also controls apoptosis and is becoming an important target for anticancer therapy. While the components that lead to NF-kB activation are progressively identified, evidence for involvement of NF-kB in multiple human pathologies (cancer, immune deficiencies, diabetes and atherosclerosis) is accumulating. However, a number of questions remain unanswered: the structure of the IKK complex needs to be solved to understand its mode of activation; the respective roles of the multiple NF-kB species have to be precisely defined; the exact function of the multiple components and branches of this cascade need to be addressed by biochemical and genetic approaches. This meeting will bring together people with diverse backgrounds and should generate interactions required for better understanding of this pathway and its associated pathophysiology. Ultimately, these interactions could be translated into new therapeutic modalities.
Scholarship Deadline: November 23 2005
Discounted Abstract Deadline: November 23 2005
Abstract Deadline: December 16 2005
Discounted Registration Deadline: January 23 2006
We gratefully acknowledge additional support for this conference from:
Celgene CorporationCell Signaling Technology, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Celgene Corporation

Genentech, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13 AI068378-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, March 23 | 3:00PM - 7:30PM
Registration
Room: Van Horne Ballroom Foyer


Thursday, March 23 | 6:30PM - 7:30PM
Refreshments
Room: Van Horne Ballroom Foyer


Thursday, March 23 | 7:30PM - 8:30PM
Keynote Address
Room: Van Horne Ballroom AB

Speaker 1 of 1
David Baltimore, California Institute of Technology, USA
NF-kappaB, 20 Years After

Friday, March 24 | 7:00AM - 8:00AM
Breakfast
Room: Alberta, New Brunswick, Riverview


Friday, March 24 | 8:00AM - 11:15AM
Signaling 1
Room: Van Horne Ballroom AB

Speaker 7 of 7
Thomas D. Gilmore, Boston University, USA
Short Talk

Friday, March 24 | 8:00AM - 11:15AM
Signaling 1
Room: Van Horne Ballroom AB

Speaker 6 of 7
Shao-Cong Sun, University of Texas MD Anderson Cancer Center, USA
Short Talk: CYLD: A Novel Target of IKK Regulating Lck Ubiquitination and T Cell Development

Friday, March 24 | 8:00AM - 11:15AM
Signaling 1
Room: Van Horne Ballroom AB

Speaker 5 of 7
Jun Zhang, National Institutes of Health, USA
Short Talk: CYLD-deficient Mice Display Impaired Regulation of NF-kB and Increased Susceptibility to Colonic Inflammation and Tumorigenesis


Friday, March 24 | 8:00AM - 11:15AM
Signaling 1
Room: Van Horne Ballroom AB

Speaker 4 of 7
George Mosialos, B.S.R.C. Alexander Fleming, Greece
Short Talk: Targeted Inactivation of the Cylindromatosis Tumor Suppressor Gene Causes Perinatal Lethality in Mice

Friday, March 24 | 8:00AM - 11:15AM
Signaling 1
Room: Van Horne Ballroom AB

Speaker 3 of 7
Sankar Ghosh, Columbia University, USA
Regulation of NF-kappaB Transcriptional Activity

Friday, March 24 | 8:00AM - 11:15AM
Signaling 1
Room: Van Horne Ballroom AB

Speaker 2 of 7
Inder M. Verma, The Salk Institute, USA
Regulation of NF-kappaB Functions

Friday, March 24 | 8:00AM - 11:15AM
Signaling 1
Room: Van Horne Ballroom AB

Speaker 1 of 7
* Alain Israël, Institut Pasteur, France

Friday, March 24 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Ballroom Foyer


Friday, March 24 | 11:15AM - 1:00PM
Poster Setup
Room: Alberta, New Brunswick, Riverview


Friday, March 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Alberta, New Brunswick, Riverview


Friday, March 24 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Ballroom Foyer


Friday, March 24 | 5:00PM - 7:00PM
Signaling 2
Room: Van Horne Ballroom AB

Speaker 4 of 4
Ezra Burstein, University of Texas Southwestern Medical Center, USA
Short Talk: COMMD Proteins Inhibit kappaB-Mediated Transcription by Promoting the Ubiquitination of NF-kappaB Subunits through a Cullin E3 Ligase

Friday, March 24 | 5:00PM - 7:00PM
Signaling 2
Room: Van Horne Ballroom AB

Speaker 3 of 4
Jorge Moscat, Sanford Burnham Prebys Institute, USA
PKCzeta Signaling in the NF-kB Pathways

Friday, March 24 | 5:00PM - 7:00PM
Signaling 2
Room: Van Horne Ballroom AB

Speaker 2 of 4
Zhijian 'James' Chen, University of Texas Southwestern Medical Center, USA
Mavericks Defense: A Tale of Host Defense Against Viral Offense

Friday, March 24 | 5:00PM - 7:00PM
Signaling 2
Room: Van Horne Ballroom AB

Speaker 1 of 4
* Vishva M. Dixit, Genentech, Inc., USA
Deciphering the Pathway from the TCR/BCR to NF-kappaB: New Functions for Old Molecules

Friday, March 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Alberta, New Brunswick, Riverview


Friday, March 24 | 7:30PM - 10:00PM
Poster Session 1
Room: Alberta, New Brunswick, Riverview


Saturday, March 25 | 7:00AM - 8:00AM
Breakfast
Room: Alberta, New Brunswick, Riverview


Saturday, March 25 | 8:00AM - 11:15AM
Immunity 1
Room: Van Horne Ballroom AB

Speaker 2 of 6
Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
NFAT and NF-kappaB: Structural and Functional Similarities and Dissimiliarities

Saturday, March 25 | 8:00AM - 11:15AM
Immunity 1
Room: Van Horne Ballroom AB

Speaker 1 of 6
Jules A. Hoffmann, Institute of Cellular and Molecular Biology, France
NF-kappaB Signaling during Bacterial and Fungal Infection

Saturday, March 25 | 8:00AM - 11:15AM
Immunity 1
Room: Van Horne Ballroom AB

Speaker 3 of 6
Tak W. Mak, Campbell Family Institute for Breast Cancer, Canada
Genetic Dissection of the NFkB Pathways

Saturday, March 25 | 8:00AM - 11:15AM
Immunity 1
Room: Van Horne Ballroom AB

Speaker 4 of 6
* Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany
In vivo Analysis of NFkappaB Function in Normal and Malignant B Cell Development


Saturday, March 25 | 8:00AM - 11:15AM
Immunity 1
Room: Van Horne Ballroom AB

Speaker 5 of 6
Steven C. Ley, Francis Crick Institute, UK
Short Talk: Regulation of the TPL-2 / ERK MAP kinase pathway

Saturday, March 25 | 8:00AM - 11:15AM
Immunity 1
Room: Van Horne Ballroom AB

Speaker 6 of 6
Sophie Janssens, VIB-UGent Center for Inflammation Research, Belgium
Short Talk

Saturday, March 25 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Ballroom Foyer


Saturday, March 25 | 11:15AM - 1:00PM
Poster Setup
Room: Alberta, New Brunswick, Riverview


Saturday, March 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Alberta, New Brunswick, Riverview


Saturday, March 25 | 2:30PM - 4:30PM
Workshop 1: Systems Biology
Room: Van Horne Ballroom AB

Speaker 1 of 9
* Andre Levchenko, Yale University, USA

Saturday, March 25 | 2:30PM - 4:30PM
Workshop 1: Systems Biology
Room: Van Horne Ballroom AB

Speaker 2 of 9
Kevin A. Janes, University of Virginia, USA
Data Models Linking Cytokines to NF-kappaB to Apoptosis

Saturday, March 25 | 2:30PM - 4:30PM
Workshop 1: Systems Biology
Room: Van Horne Ballroom AB

Speaker 3 of 9
Erin H. Breese, Indiana University School of Medicine, USA
Elucidating SIMPL’s Co-Activator Function through Characterization of Protein-Protein Interactions and NF-kappaB Dependent Promoter Occupancy

Saturday, March 25 | 2:30PM - 4:30PM
Workshop 1: Systems Biology
Room: Van Horne Ballroom AB

Speaker 4 of 9
Raymond Cheong, Johns Hopkins University, USA
Towards Systems-Level Understanding of NF-kappaB Signaling through Integrated Modeling and Experimentation

Saturday, March 25 | 2:30PM - 4:30PM
Workshop 1: Systems Biology
Room: Van Horne Ballroom AB

Speaker 5 of 9
Barbara Kaltschmidt, Bielefeld University, Germany
NF-kappaB Regulates Memory Formation and Synaptic Plasticity through PKA/CREB Signaling

Saturday, March 25 | 2:30PM - 4:30PM
Workshop 1: Systems Biology
Room: Van Horne Ballroom AB

Speaker 6 of 9
Stephnie M. Kennedy, University of Liverpool, UK
Development of Higher throughput Dynamic Imaging of the Function of NF-kappaB Proteins

Saturday, March 25 | 2:30PM - 4:30PM
Workshop 1: Systems Biology
Room: Van Horne Ballroom AB

Speaker 7 of 9
Alison M. O'Mahony, Bioseek Inc, USA
NF-kappaB/Rel is a Key Regulator of Inhibitory Neuron Function and Synaptic Plasticity

Saturday, March 25 | 2:30PM - 4:30PM
Workshop 1: Systems Biology
Room: Van Horne Ballroom AB

Speaker 8 of 9
Irina A. Udalova, University of Oxford, UK
Static and Dynamic Conservation of NF-kappaB Binding Sites in Drosophilid Genomes

Saturday, March 25 | 2:30PM - 4:30PM
Workshop 1: Systems Biology
Room: Van Horne Ballroom AB

Speaker 9 of 9
Zhong Chen, NIDCD, National Institutes of Health, USA
Molecular Profiling Distinguishes Head and Neck Squamous Cell Carcinomas Expressing Novel Gene Signatures Related to NF-kappaB and p53 Status

Saturday, March 25 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Ballroom Foyer


Saturday, March 25 | 5:00PM - 7:00PM
Immunity 2
Room: Van Horne Ballroom AB

Speaker 1 of 4
Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Toll pathway of innate immunity

Saturday, March 25 | 5:00PM - 7:00PM
Immunity 2
Room: Van Horne Ballroom AB

Speaker 2 of 4
Akira Shizuo, Osaka University, Japan
TLR-dependent and-independent signaling pathways in pathogen recognition

Saturday, March 25 | 5:00PM - 7:00PM
Immunity 2
Room: Van Horne Ballroom AB

Speaker 3 of 4
* Ulrich K. Siebenlist, NIAID, National Institutes of Health, USA
Roles of NF-kappaB in Control of Autoimmunity

Saturday, March 25 | 5:00PM - 7:00PM
Immunity 2
Room: Van Horne Ballroom AB

Speaker 4 of 4
Kenya Honda, Keio University School of Medicine, Japan
Short Talk: Regulation of MyD88-Dependent Signaling Pathways by IRF-1

Saturday, March 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Alberta, New Brunswick, Riverview


Saturday, March 25 | 7:30PM - 10:00PM
Poster Session 2
Room: Alberta, New Brunswick, Riverview


Sunday, March 26 | 7:00AM - 8:00AM
Breakfast
Room: Alberta, New Brunswick, Riverview


Sunday, March 26 | 8:00AM - 11:00AM
Transcription
Room: Van Horne Ballroom AB

Speaker 1 of 6
Tom Maniatis, New York Genome Center, USA
Distinct Roles of TBK1 AND IKKe in Anti-Viral Immunity

Sunday, March 26 | 8:00AM - 11:00AM
Transcription
Room: Van Horne Ballroom AB

Speaker 2 of 6
* Albert S. Baldwin Jr., University of North Carolina School of Medicine, USA
NF-kappaB/IKK Pathways in Control of Gene Expression and Oncogenesis

Sunday, March 26 | 8:00AM - 11:00AM
Transcription
Room: Van Horne Ballroom AB

Speaker 3 of 6
Alexander Hoffmann, University of California, Los Angeles, USA
Achieving Stimulus-Specific Gene Expression via NF-kappaB

Sunday, March 26 | 8:00AM - 11:00AM
Transcription
Room: Van Horne Ballroom AB

Speaker 4 of 6
Yinon M. Ben-Neriah, Hebrew University, Hadassah Medical School, Israel
Tissue Specific Control of NF-kappaB Activation

Sunday, March 26 | 8:00AM - 11:00AM
Transcription
Room: Van Horne Ballroom AB

Speaker 5 of 6
Genhong Cheng, University of California, Los Angeles, USA
Short Talk: Rescue of TRAF3 Null Mice by p100 NF-kB Deficiency

Sunday, March 26 | 8:00AM - 11:00AM
Transcription
Room: Van Horne Ballroom AB

Speaker 6 of 6
Denis C. Guttridge, Ohio State University, USA
Short Talk

Sunday, March 26 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Ballroom Foyer


Sunday, March 26 | 11:00AM - 1:00PM
Poster Setup
Room: Alberta, New Brunswick, Riverview


Sunday, March 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Alberta, New Brunswick, Riverview


Sunday, March 26 | 2:30PM - 4:30PM
Workshop 2: Diseases and Therapeutics
Room: Van Horne Ballroom AB

Speaker 1 of 9
* Frank Mercurio, BioTheryX, Inc., USA

Sunday, March 26 | 2:30PM - 4:30PM
Workshop 2: Diseases and Therapeutics
Room: Van Horne Ballroom AB

Speaker 2 of 9
Roberta Brambilla, University of Miami, USA
Transgenic Inactivation of Astroglial NF-kappaB Improves Functional Recovery Following Spinal Cord Injury and Experimental Autoimmune Encephalomyelitis

Sunday, March 26 | 2:30PM - 4:30PM
Workshop 2: Diseases and Therapeutics
Room: Van Horne Ballroom AB

Speaker 3 of 9
Jessica E. Hutti, AbbVie, Inc., USA
The Role of IKK Substrate Specificity in Coordinating Innate Immune Signaling Responses

Sunday, March 26 | 2:30PM - 4:30PM
Workshop 2: Diseases and Therapeutics
Room: Van Horne Ballroom AB

Speaker 4 of 9
Scott J. Russo, Icahn School of Medicine at Mount Sinai, USA
NF-kappaB Signaling Controls Behavioral and Cellular Plasticity Associated with Cocaine Addiction

Sunday, March 26 | 2:30PM - 4:30PM
Workshop 2: Diseases and Therapeutics
Room: Van Horne Ballroom AB

Speaker 5 of 9
Carter Van Waes, NIDCD, National Institutes of Health, USA
The Proteasome, IKK, and p53 in Activation of NF-kappaB and Therapy of Head and Neck Squamous Cell Carcinoma

Sunday, March 26 | 2:30PM - 4:30PM
Workshop 2: Diseases and Therapeutics
Room: Van Horne Ballroom AB

Speaker 6 of 9
Catherine E. Wharry, University of Pennsylvania, USA
Non-Canonical NF-kappaB Regulation in Pancreatic Ductal Carcinoma

Sunday, March 26 | 2:30PM - 4:30PM
Workshop 2: Diseases and Therapeutics
Room: Van Horne Ballroom AB

Speaker 7 of 9
Florian R. Greten, Institute for Tumor Biology and Experimental Therapy, Germany
Increased IL-1beta Processing Leads to Impaired Survival of Myeloid Specific IKKbeta Deficient Mice during LPS-Induced Septic Shock

Sunday, March 26 | 2:30PM - 4:30PM
Workshop 2: Diseases and Therapeutics
Room: Van Horne Ballroom AB

Speaker 8 of 9
Derek A. Mann, Newcastle University, UK
Real-Time in vivo Analysis of NF-kappaB Activation Reveals a Role for the Liver as a Regulator of Acute Brain Inflammation

Sunday, March 26 | 2:30PM - 4:30PM
Workshop 2: Diseases and Therapeutics
Room: Van Horne Ballroom AB

Speaker 9 of 9
Thomas Wirth, Ulm University, Germany
Constitutive Activation of IKK2 is Sufficient to Induce Pancreatitis

Sunday, March 26 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Ballroom Foyer


Sunday, March 26 | 5:00PM - 7:00PM
Cancer
Room: Van Horne Ballroom AB

Speaker 1 of 4
Shigeki Miyamoto, University of Wisconsin, Madison, USA
Mechanisms of NF-kappaB Activation in Response to Genotoxic Stimuli.

Sunday, March 26 | 5:00PM - 7:00PM
Cancer
Room: Van Horne Ballroom AB

Speaker 2 of 4
* Claus Scheidereit, Max Delbrück Center for Molecular Medicine, Germany
NF-kappaB Function in Tumor Cells and Morphogenesis

Sunday, March 26 | 5:00PM - 7:00PM
Cancer
Room: Van Horne Ballroom AB

Speaker 3 of 4
Manolis Pasparakis, University of Cologne, Germany
Function of IKK Subunits in Physiology and Disease

Sunday, March 26 | 5:00PM - 7:00PM
Cancer
Room: Van Horne Ballroom AB

Speaker 4 of 4
Laura M. DeBusk, Vanderbilt University, USA
Short Talk: IKK-alpha Activation Induces Tumor Angiogenesis

Sunday, March 26 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Alberta, New Brunswick, Riverview


Sunday, March 26 | 7:30PM - 10:00PM
Poster Session 3
Room: Alberta, New Brunswick, Riverview


Monday, March 27 | 7:00AM - 8:00AM
Breakfast
Room: Alberta, New Brunswick, Riverview


Monday, March 27 | 8:00AM - 11:15AM
Human Pathologies/Global System Analysis 1
Room: Van Horne Ballroom AB

Speaker 1 of 6
* Michael Karin, University of California, San Diego, USA
The IKK Complex and its Role in Normal and Diseased Tissues

Monday, March 27 | 8:00AM - 11:15AM
Human Pathologies/Global System Analysis 1
Room: Van Horne Ballroom AB

Speaker 2 of 6
* Steve D. Gerondakis, Monash University, Australia
NF-kappaB Regulation of Myeloid Differentiation

Monday, March 27 | 8:00AM - 11:15AM
Human Pathologies/Global System Analysis 1
Room: Van Horne Ballroom AB

Speaker 3 of 6
Giulio Superti-Furga, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Austria
Mapping Complex Regulatory Networks

Monday, March 27 | 8:00AM - 11:15AM
Human Pathologies/Global System Analysis 1
Room: Van Horne Ballroom AB

Speaker 4 of 6
Mollie K. Meffert, Johns Hopkins University School of Medicine, USA
NF-kappaB in Synaptic Function:

Monday, March 27 | 8:00AM - 11:15AM
Human Pathologies/Global System Analysis 1
Room: Van Horne Ballroom AB

Speaker 5 of 6
Deborah Veis Novack, Washington University, USA
Short Talk: RelB is Critical for Stimulated Osteoclastogenesis

Monday, March 27 | 8:00AM - 11:15AM
Human Pathologies/Global System Analysis 1
Room: Van Horne Ballroom AB

Speaker 6 of 6
Brendan J. O'Sullivan, Centre for Immunology and Cancer Research, Australia
Short Talk: RelB Serves a Dual Role in Hemopoietic and Stromal Cell Compartments to Maintain Tolerance and Contain Inflammation through Dendritic Cells and Regulatory T Cells

Monday, March 27 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Ballroom Foyer


Monday, March 27 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Ballroom Foyer


Monday, March 27 | 5:00PM - 7:00PM
Human Pathologies/Global System Analysis 2
Room: Van Horne Ballroom AB

Speaker 1 of 4
* Alain Israël, Institut Pasteur, France
Genetic and Biochemical Analysis of the NF-ƒÛB Signaling Cascade

Monday, March 27 | 5:00PM - 7:00PM
Human Pathologies/Global System Analysis 2
Room: Van Horne Ballroom AB

Speaker 2 of 4
Louis M. Staudt, NCI, National Institutes of Health, USA
Genetic Screens with an RNA Interference Library to Identify New Molecular Targets in Cancer

Monday, March 27 | 5:00PM - 7:00PM
Human Pathologies/Global System Analysis 2
Room: Van Horne Ballroom AB

Speaker 3 of 4
Howard Y. Chang, Stanford University, USA
Short Talk: Reversal of Epidermal Aging by NF-kappaB Blockade

Monday, March 27 | 5:00PM - 7:00PM
Human Pathologies/Global System Analysis 2
Room: Van Horne Ballroom AB

Speaker 4 of 4
Daniel Krappmann, Helmholtz Zentrum München, Germany
Short Talk

Monday, March 27 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Alberta, New Brunswick


Monday, March 27 | 8:00PM - 11:00PM
Entertainment
Room: Alberta, New Brunswick


Monday, March 27 | 8:00PM - 11:00PM
Cash Bar
Room: Alberta, New Brunswick


Tuesday, March 28 | 10:26AM - 10:26AM
Departure


*Session Chair.