NF-kappaB: 20 Years on the Road from Biochemistry to Pathology

Organizer(s): Alain Israël, David Baltimore and Yinon M. Ben-Neriah

Supported by The Director's Fund

Summary of Meeting:

The NF-kB signaling pathway is a critical determinant of the inflammatory response, and is involved in both innate and acquired immunity. It also controls apoptosis and is becoming an important target for anticancer therapy. While the components that lead to NF-kB activation are progressively identified, evidence for involvement of NF-kB in multiple human pathologies (cancer, immune deficiencies, diabetes and atherosclerosis) is accumulating. However, a number of questions remain unanswered: the structure of the IKK complex needs to be solved to understand its mode of activation; the respective roles of the multiple NF-kB species have to be precisely defined; the exact function of the multiple components and branches of this cascade need to be addressed by biochemical and genetic approaches. This meeting will bring together people with diverse backgrounds and should generate interactions required for better understanding of this pathway and its associated pathophysiology. Ultimately, these interactions could be translated into new therapeutic modalities.

Scholarship Deadline: November 23 2005

Discounted Abstract Deadline: November 23 2005

Abstract Deadline: December 16 2005

Discounted Registration Deadline: January 23 2006

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Celgene Corporation

Genentech, Inc.

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13 AI068378-01

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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