Allergy, Allergic Inflammation and Asthma

Organizer(s): Donata Vercelli, Stephen J. Galli, Paul B. Rothman

Sponsored by Sanofi Aventis Pharmaceuticals, Inc.

Summary of Meeting:

Much of the morbidity of asthma and other allergic disorders is now thought to reflect the consequences of the inflammation that develops in these settings. Accordingly, understanding the origins, expression and tissue effects of allergic inflammation is a rapidly developing field at the interface between basic and clinical research. Exciting work currently focuses on the following: • the genetic basis of allergic inflammation, and how genetic and environmental factors interact to shape the pathogenesis of this process; • the interface between innate and adaptive immunity as a regulator of Th2 responses, and the role of T regulatory cells; • the regulation of Th2 signaling. However, some major problems remain unsolved, particularly: • the developmental origins of allergic inflammation; • the relative contributions of distinct molecules and/or cells to the pathogenesis of allergic inflammation in the lung; • the heterogeneity of human asthma phenotypes and responses to treatment. The main goal of this meeting is to advance understanding of allergic inflammation by assembling field leaders to discuss the most exciting areas of current research and to suggest potentially fruitful directions for future work. Dedicated sessions and/or workshops will address the major problems still unsolved in an attempt to facilitate their solution.

Scholarship Deadline: December 6 2005

Discounted Abstract Deadline: December 6 2005

Abstract Deadline: December 29 2005

Discounted Registration Deadline: February 6 2006

We gratefully acknowledge additional support for this conference from:

GlaxoSmithKline Research & Development, Ltd.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Dynavax Technologies Corporation

Nuvelo

Peptimmune, Inc.

We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13 AI068367-01

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