Web Desc
Allergy, Allergic Inflammation and Asthma
Organizer(s): Donata Vercelli, Stephen J. Galli, Paul B. Rothman
Date: April 06 - 11, 2006
Location: Beaver Run Resort, Breckenridge, CO, USA
Sponsored by Sanofi Aventis Pharmaceuticals, Inc.
Summary of Meeting:
Much of the morbidity of asthma and other allergic disorders is now thought to reflect the consequences of the inflammation that develops in these settings. Accordingly, understanding the origins, expression and tissue effects of allergic inflammation is a rapidly developing field at the interface between basic and clinical research. Exciting work currently focuses on the following: • the genetic basis of allergic inflammation, and how genetic and environmental factors interact to shape the pathogenesis of this process; • the interface between innate and adaptive immunity as a regulator of Th2 responses, and the role of T regulatory cells; • the regulation of Th2 signaling. However, some major problems remain unsolved, particularly: • the developmental origins of allergic inflammation; • the relative contributions of distinct molecules and/or cells to the pathogenesis of allergic inflammation in the lung; • the heterogeneity of human asthma phenotypes and responses to treatment. The main goal of this meeting is to advance understanding of allergic inflammation by assembling field leaders to discuss the most exciting areas of current research and to suggest potentially fruitful directions for future work. Dedicated sessions and/or workshops will address the major problems still unsolved in an attempt to facilitate their solution.
Scholarship Deadline: December 6 2005
Discounted Abstract Deadline: December 6 2005
Abstract Deadline: December 29 2005
Discounted Registration Deadline: February 6 2006
We gratefully acknowledge additional support for this conference from:
Educational donation provided by Amgen
GlaxoSmithKline Research & Development, Ltd.
Novartis Institutes for BioMedical ResearchSanofi US
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Dynavax Technologies Corporation

Nuvelo

Peptimmune, Inc.
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1R13 AI068367-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, April 06 | 3:00PM - 7:30PM
Registration
Room: Foyer


Thursday, April 06 | 6:30PM - 7:30PM
Refreshments
Room: Foyer


Thursday, April 06 | 7:30PM - 7:45PM
Opening Remarks

Speaker 1 of 1
Donata Vercelli, University of Arizona, USA
Welcome to the Conference and Introduction of Keynote Speaker

Thursday, April 06 | 7:45PM - 8:45PM
Keynote Address
Room: Peaks 4-5

Speaker 1 of 1
William E. Paul, NIAID, National Institutes of Health, USA
IL4 and Th2 Cells: Regulation and Homeostasis

Friday, April 07 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Friday, April 07 | 8:00AM - 11:15AM
Impact of Genes and Environment on Allergy and Allergic Infl
ammation

Room: Peaks 4-5

Speaker 1 of 6
* Erika von Mutius, University Children's Hospital, Munich, Germany
Epidemiology and the Environment

Friday, April 07 | 8:00AM - 11:15AM
Impact of Genes and Environment on Allergy and Allergic Infl
ammation

Room: Peaks 4-5

Speaker 2 of 6
William O.C. Cookson, Wellcome Trust Centre for Human Genetics, UK
The Genes of Allergic Inflammation

Friday, April 07 | 8:00AM - 11:15AM
Impact of Genes and Environment on Allergy and Allergic Infl
ammation

Room: Peaks 4-5

Speaker 3 of 6
Carole Ober, University of Chicago, USA
Sex-Specific Genetic Architecture of Asthma-Associated Quantitative Trait Loci in the Hutterites

Friday, April 07 | 8:00AM - 11:15AM
Impact of Genes and Environment on Allergy and Allergic Infl
ammation

Room: Peaks 4-5

Speaker 4 of 6
Donata Vercelli, University of Arizona, USA
Functional Genomics in an Evolutionary Framework: IL13 and Allergic Inflammation

Friday, April 07 | 8:00AM - 11:15AM
Impact of Genes and Environment on Allergy and Allergic Infl
ammation

Room: Peaks 4-5

Speaker 5 of 6
Matthew E. Poynter, University of Vermont, USA
Short Talk: Toll-Like Receptor (TLR)2 is Necessary for Nitrogen Dioxide (NO2)-Induced Allergic Sensitization to Inhaled Antigen

Friday, April 07 | 8:00AM - 11:15AM
Impact of Genes and Environment on Allergy and Allergic Infl
ammation

Room: Peaks 4-5

Speaker 6 of 6
Mayumi Tamari, RIKEN, SNP Research Center, Japan
Short Talk: Functional Haplotypes of IL-12B are Associated with Childhood Atopic Asthma

Friday, April 07 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Friday, April 07 | 11:15AM - 1:00PM
Poster Setup
Room: Peaks 1-3


Friday, April 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-3


Friday, April 07 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Friday, April 07 | 5:00PM - 7:00PM
Pharmacological Targets in Allergic Inflammation and Asthma
Room: Peaks 4-5

Speaker 1 of 4
* K. Frank Austen, Harvard Medical School, USA
Innate and Adaptive Immune Functions of the Cysteinyl Leukotrienes (CyslTs)

Friday, April 07 | 5:00PM - 7:00PM
Pharmacological Targets in Allergic Inflammation and Asthma
Room: Peaks 4-5

Speaker 2 of 4
Roland W. Kolbeck, MedImmune, LLC, USA
Targeting Chemokine Receptors for the Treatment of Asthma: Critical Role for Mast Cell-Derived CCL1 and CCR8+ T-Helper 2 (Th2) Effector Cells?

Friday, April 07 | 5:00PM - 7:00PM
Pharmacological Targets in Allergic Inflammation and Asthma
Room: Peaks 4-5

Speaker 3 of 4
Fernando D. Martinez, University of Arizona, USA
Genetics of Response to Asthma Therapy: Which are the Right Phenotypes to Study?

Friday, April 07 | 5:00PM - 7:00PM
Pharmacological Targets in Allergic Inflammation and Asthma
Room: Peaks 4-5

Speaker 4 of 4
William M. Gwinn, George Washington University Medical Center, USA
Short Talk: Blocking Extracellular Cyclophilin-CD147 Interactions Significantly Inhibits Asthma-Mediated Lung Inflammation

Friday, April 07 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-3


Friday, April 07 | 7:30PM - 10:00PM
Poster Session 1
Room: Peaks 1-3


Saturday, April 08 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Saturday, April 08 | 8:00AM - 11:15AM
Role of Innate Immunity in the Pathogenesis of Allergy and A
llergic Inflammation

Room: Peaks 4-5

Speaker 1 of 6
* Kim Bottomly, Yale University School of Medicine, USA
Innate Control of CD4 T Cell Responses to Inhaled Antigen


Saturday, April 08 | 8:00AM - 11:15AM
Role of Innate Immunity in the Pathogenesis of Allergy and A
llergic Inflammation

Room: Peaks 4-5

Speaker 2 of 6
Bart N. Lambrecht, VIB, Ghent University, Belgium
Dendritic Cells in Allergic Inflammation

Saturday, April 08 | 8:00AM - 11:15AM
Role of Innate Immunity in the Pathogenesis of Allergy and A
llergic Inflammation

Room: Peaks 4-5

Speaker 3 of 6
Maria Yazdanbakhsh, Leiden University Medical Center, Netherlands
Parasites and Immune Regulation: The Link to Allergy

Saturday, April 08 | 8:00AM - 11:15AM
Role of Innate Immunity in the Pathogenesis of Allergy and A
llergic Inflammation

Room: Peaks 4-5

Speaker 4 of 6
Graham A.W. Rook, Royal Free and University College Medical School, UK
How Broad is the Role of the Microbial Environment in Mammalian Homoeostasis?

Saturday, April 08 | 8:00AM - 11:15AM
Role of Innate Immunity in the Pathogenesis of Allergy and A
llergic Inflammation

Room: Peaks 4-5

Speaker 5 of 6
Sonja Kierstein, University of Pennsylvania, USA
Short Talk: Local Gene Expression Profiling Suggests Altered Dendritic Cell (DC) Function in Surfactant Protein D (SP-D) Deficient Mice

Saturday, April 08 | 8:00AM - 11:15AM
Role of Innate Immunity in the Pathogenesis of Allergy and A
llergic Inflammation

Room: Peaks 4-5

Speaker 6 of 6
Toshinori Nakayama, Chiba University, Japan
Short Talk: Regulation of Allergic Airway Inflammation through Toll Like Receptor 4-Mediated Modification of Mast Cell Function

Saturday, April 08 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Saturday, April 08 | 11:15AM - 1:00PM
Poster Setup
Room: Peaks 1-3


Saturday, April 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-3


Saturday, April 08 | 2:30PM - 4:30PM
Workshop 1: Genetic, Developmental and Environmental Factors
in Allergic Inflammation
Room: Peaks 4-5

Speaker 1 of 9
* Donata Vercelli, University of Arizona, USA

Saturday, April 08 | 2:30PM - 4:30PM
Workshop 1: Genetic, Developmental and Environmental Factors
in Allergic Inflammation
Room: Peaks 4-5

Speaker 2 of 9
Miriam F. Moffatt, University of Oxford, UK
A Pan-European Study of Genetic Asthma Susceptibility in the ISAAC II Survey

Saturday, April 08 | 2:30PM - 4:30PM
Workshop 1: Genetic, Developmental and Environmental Factors
in Allergic Inflammation
Room: Peaks 4-5

Speaker 3 of 9
Alexey V. Fedulov, Harvard School of Public Health, USA
Environmental Particle Exposures During Pregnancy Cause Increased Allergic Susceptibility In Offspring

Saturday, April 08 | 2:30PM - 4:30PM
Workshop 1: Genetic, Developmental and Environmental Factors
in Allergic Inflammation
Room: Peaks 4-5

Speaker 4 of 9
Maike K. Knackstedt, Charité, Germany
Exposure to Stress during Pregnancy Increases Susceptibility of Murine Offspring Towards Allergic Diseases

Saturday, April 08 | 2:30PM - 4:30PM
Workshop 1: Genetic, Developmental and Environmental Factors
in Allergic Inflammation
Room: Peaks 4-5

Speaker 5 of 9
Wayne G. Shreffler, Massachusetts General Hospital/Harvard Medical School, USA
The Major Glycoprotein Allergen from Arachis hypogaea, Ara h 1, May Facilitate Th2 Priming through its Specific Recognition by DC-SIGN

Saturday, April 08 | 2:30PM - 4:30PM
Workshop 1: Genetic, Developmental and Environmental Factors
in Allergic Inflammation
Room: Peaks 4-5

Speaker 6 of 9
Hermelijn H. Smits, Leiden University Center, Netherlands
Experimental Chronic Schistosoma mansoni Infection Protects Mice from the Development of Allergic Asthma

Saturday, April 08 | 2:30PM - 4:30PM
Workshop 1: Genetic, Developmental and Environmental Factors
in Allergic Inflammation
Room: Peaks 4-5

Speaker 7 of 9
Zheng Tan, University of Chicago, USA
A Polymorphism in the HLA-G 3’-UTR Influences Targeting of miR-148a, -148b and -152 and is Associated with Asthma

Saturday, April 08 | 2:30PM - 4:30PM
Workshop 1: Genetic, Developmental and Environmental Factors
in Allergic Inflammation
Room: Peaks 4-5

Speaker 8 of 9
Valerie Verhasselt, INSERM, France
Breast-Feeding Induced Tolerance in a Murine Model of Asthma

Saturday, April 08 | 2:30PM - 4:30PM
Workshop 1: Genetic, Developmental and Environmental Factors
in Allergic Inflammation
Room: Peaks 4-5

Speaker 9 of 9
Robin B. Webster, University of Arizona, USA
The Human IL-13 Locus in Neonatal CD4 T cells is Refractory to the Acquisition of a Repressive Chromatin Architecture

Saturday, April 08 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Saturday, April 08 | 5:00PM - 7:00PM
Regulatory Cells in Allergic Inflammation
Room: Peaks 4-5

Speaker 1 of 4
Alexander Y. Rudensky, HHMI/Memorial Sloan Kettering Cancer Center, USA
Molecular Regulation of Regulatory CD4 T Cell Development and Maintenance

Saturday, April 08 | 5:00PM - 7:00PM
Regulatory Cells in Allergic Inflammation
Room: Peaks 4-5

Speaker 2 of 4
* Dale T. Umetsu, Genentech, Inc., USA
The Regulation of Asthma by NKT Cells

Saturday, April 08 | 5:00PM - 7:00PM
Regulatory Cells in Allergic Inflammation
Room: Peaks 4-5

Speaker 3 of 4
Mubeccel Akdis, Swiss Institute of Allergy and Asthma Research, Switzerland
Fine Tuning of Allergen-Specific Human T Regulatory Responses

Saturday, April 08 | 5:00PM - 7:00PM
Regulatory Cells in Allergic Inflammation
Room: Peaks 4-5

Speaker 4 of 4
Mark S. Wilson, Genentech, Inc., USA
Short Talk: Protection from Allergy and Autoimmunity by Helminth-Induced B Cells

Saturday, April 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-3


Saturday, April 08 | 7:30PM - 10:00PM
Poster Session 2
Room: Peaks 1-3


Sunday, April 09 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Sunday, April 09 | 8:00AM - 11:00AM
Th2 Differentiation and Th2 Effector Responses
Room: Peaks 4-5

Speaker 1 of 5
Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
T Cell Differentiation and microRNAs

Sunday, April 09 | 8:00AM - 11:00AM
Th2 Differentiation and Th2 Effector Responses
Room: Peaks 4-5

Speaker 2 of 5
* Paul B. Rothman, University of Iowa, USA
The Role of SOCS Proteins in Regulating Allergic Immune Responses

Sunday, April 09 | 8:00AM - 11:00AM
Th2 Differentiation and Th2 Effector Responses
Room: Peaks 4-5

Speaker 3 of 5
Mark H. Kaplan, Indiana University School of Medicine, USA
Short Talk: PU.1 Expression Defines Heterogeneity in Primary Th2 Cultures

Sunday, April 09 | 8:00AM - 11:00AM
Th2 Differentiation and Th2 Effector Responses
Room: Peaks 4-5

Speaker 4 of 5
Benjamin D. Medoff, Massachusetts General Hospital, USA
Short Talk: CARMA1 is Critical for the Development of Allergic Airway Inflammation in a Murine Model of Asthma

Sunday, April 09 | 8:00AM - 11:00AM
Th2 Differentiation and Th2 Effector Responses
Room: Peaks 4-5

Speaker 5 of 5
Steven F. Ziegler, Benaroya Research Institute, USA
Short Talk: TSLP is Necessary and Sufficient for the Development of Asthma

Sunday, April 09 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Sunday, April 09 | 11:00AM - 1:00PM
Poster Setup
Room: Peaks 1-3


Sunday, April 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 1-3


Sunday, April 09 | 2:30PM - 4:30PM
Workshop 2: Mouse Models for Investigating Allergic Inflamma
tion and its Treatment
Room: Peaks 4-5

Speaker 1 of 9
* Stephen J. Galli, Stanford University, USA

Sunday, April 09 | 2:30PM - 4:30PM
Workshop 2: Mouse Models for Investigating Allergic Inflamma
tion and its Treatment
Room: Peaks 4-5

Speaker 2 of 9
Bryan S. Clay, University of Chicago, USA
Genetic Predisposition to Express Higher Surface Levels of ICOS on T Cells Regulates the Magnitude of Th2-Mediated Airway Inflammation in a Murine Model of Asthma

Sunday, April 09 | 2:30PM - 4:30PM
Workshop 2: Mouse Models for Investigating Allergic Inflamma
tion and its Treatment
Room: Peaks 4-5

Speaker 3 of 9
John R. Gordon, University of Saskatchewan, Canada
Dendritic Cell Therapy Abrogates Local and Systemic Asthma Responses Via Initiation of Infectious Tolerance

Sunday, April 09 | 2:30PM - 4:30PM
Workshop 2: Mouse Models for Investigating Allergic Inflamma
tion and its Treatment
Room: Peaks 4-5

Speaker 4 of 9
James G. Karras, Janssen R&D, USA
Combination Studies of Topically Administered Interleukin-4 Receptor-alpha Antisense Oligonucleotide and Budesonide in Mouse Models of Allergic Inflammation

Sunday, April 09 | 2:30PM - 4:30PM
Workshop 2: Mouse Models for Investigating Allergic Inflamma
tion and its Treatment
Room: Peaks 4-5

Speaker 5 of 9
Mirjam Kool, Erasmus MC, Netherlands
Plasmacytoid Dendritic Cells Dampen Eosinophilic Airway Inflammation in a Mouse Model for Asthma

Sunday, April 09 | 2:30PM - 4:30PM
Workshop 2: Mouse Models for Investigating Allergic Inflamma
tion and its Treatment
Room: Peaks 4-5

Speaker 6 of 9
Erika Rickel, Amgen Inc., USA
TH2-Associated Effects of Intranasal Murine IL-17E can be Antagonized by Murine IL-17RB Fc

Sunday, April 09 | 2:30PM - 4:30PM
Workshop 2: Mouse Models for Investigating Allergic Inflamma
tion and its Treatment
Room: Peaks 4-5

Speaker 7 of 9
Erdyni N. Tsitsikov, Harvard Medical School, USA
Non-T Cell TRAF1 is Required for Allergic Lung Inflammation in Mice

Sunday, April 09 | 2:30PM - 4:30PM
Workshop 2: Mouse Models for Investigating Allergic Inflamma
tion and its Treatment
Room: Peaks 4-5

Speaker 8 of 9
Nicholas van Panhuys, NIAID, National Institutes of Health, USA
The Role of IL4 and STAT6 in Th2 Immune Responses and Protective Immunity

Sunday, April 09 | 2:30PM - 4:30PM
Workshop 2: Mouse Models for Investigating Allergic Inflamma
tion and its Treatment
Room: Peaks 4-5

Speaker 9 of 9
Tomohiro Yoshimoto, Hyogo College of Medicine, Japan
Role of IL-18-Induced Mucosal Mast Cells in Nematode Expulsion

Sunday, April 09 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Sunday, April 09 | 5:00PM - 7:00PM
Regulation of Allergic Inflammation
Room: Peaks 4-5

Speaker 1 of 4
* Hannah J. Gould, King's College London, UK
IgE Switching and Somatic Hypermutation in Tissues

Sunday, April 09 | 5:00PM - 7:00PM
Regulation of Allergic Inflammation
Room: Peaks 4-5

Speaker 2 of 4
Raif S. Geha, Harvard Medical School, USA
Molecular Mechanisms of IgE Isotype Switching

Sunday, April 09 | 5:00PM - 7:00PM
Regulation of Allergic Inflammation
Room: Peaks 4-5

Speaker 3 of 4
Hajime Karasuyama, Tokyo Medical and Dental University, Graduate School, Japan
Short Talk: Basophils Play a Critical Role in the Development of IgE-Mediated Chronic Allergic Inflammation Independently of T Cells and Mast Cells

Sunday, April 09 | 5:00PM - 7:00PM
Regulation of Allergic Inflammation
Room: Peaks 4-5

Speaker 4 of 4
Tiffany A. Reese, University of Texas Southwestern Medical Center, USA
Short Talk: Acidic Mammalian Chitinase (AMCase) Negatively Regulates Lung Inflammation

Sunday, April 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-3


Sunday, April 09 | 7:30PM - 10:00PM
Poster Session 3
Room: Peaks 1-3


Monday, April 10 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Monday, April 10 | 8:00AM - 11:15AM
Effector Mechanisms of Allergic Inflammation
Room: Peaks 4-5

Speaker 1 of 6
Marc E. Rothenberg, Cincinnati Children's Hospital Medical Center, USA
Novel Effector Molecules in Allergic Inflammation

Monday, April 10 | 8:00AM - 11:15AM
Effector Mechanisms of Allergic Inflammation
Room: Peaks 4-5

Speaker 2 of 6
Stephen J. Galli, Stanford University, USA
Mast Cells: 'Tunable' Regulators of Acute, Late Phase and Chronic Components of Allergic Inflammation

Monday, April 10 | 8:00AM - 11:15AM
Effector Mechanisms of Allergic Inflammation
Room: Peaks 4-5

Speaker 3 of 6
Angela Haczku, University of California, Davis, USA
Epithelial Cell Derived Innate Immune Molecules in Allergic Airway Inflammation

Monday, April 10 | 8:00AM - 11:15AM
Effector Mechanisms of Allergic Inflammation
Room: Peaks 4-5

Speaker 4 of 6
* Marsha Wills-Karp, Johns Hopkins Bloomberg School of Public Health, USA
Identification of Comliment Factor 5 as an Asthma Susceptibility Gene

Monday, April 10 | 8:00AM - 11:15AM
Effector Mechanisms of Allergic Inflammation
Room: Peaks 4-5

Speaker 5 of 6
Pierre Bruhns, Institut Pasteur, France
Short Talk: FcgammaRIV: A Novel Murine IgE Receptor

Monday, April 10 | 8:00AM - 11:15AM
Effector Mechanisms of Allergic Inflammation
Room: Peaks 4-5

Speaker 6 of 6
John T. Pesce, Henry M. Jackson Foundation, USA
Short Talk: The IL-21 Receptor Augments TH2 Effector Functions and Alternative Macrophage Activation

Monday, April 10 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Monday, April 10 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Monday, April 10 | 5:00PM - 7:00PM
Targeting the Pathogenetic Mechanisms of Allergic Inflammati
on

Room: Peaks 4-5

Speaker 1 of 4
* Patrick G. Holt, University of Western Australia, Australia
Drug Development Strategies in Asthma: In Search of a New Paradigm

Monday, April 10 | 5:00PM - 7:00PM
Targeting the Pathogenetic Mechanisms of Allergic Inflammati
on

Room: Peaks 4-5

Speaker 2 of 4
Robert L. Coffman, Dynavax Technologies, USA
Redirecting the Immune Response with Immunostimulatory DNA

Monday, April 10 | 5:00PM - 7:00PM
Targeting the Pathogenetic Mechanisms of Allergic Inflammati
on

Room: Peaks 4-5

Speaker 3 of 4
Rudolf Valenta, University of Vienna, Austria
From allergen structure to new forms of diagnosis and therapy of allergy

Monday, April 10 | 5:00PM - 7:00PM
Targeting the Pathogenetic Mechanisms of Allergic Inflammati
on

Room: Peaks 4-5

Speaker 4 of 4
Katinka A. Vigh, University of Chicago, USA
Short Talk: Phenotyping Allergen Sensitization Using Protein Arrays

Monday, April 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 1-3


Monday, April 10 | 8:00PM - 11:00PM
Entertainment
Room: Peaks 1-3


Monday, April 10 | 8:00PM - 11:00PM
Cash Bar
Room: Peaks 1-3


Tuesday, April 11 | 10:26AM - 10:26AM
Departure


*Session Chair.