Web Desc
Wnt and beta-Catenin Signaling in Development and Disease
Organizer(s): Mariann Bienz and Hans C. Clevers
Date: April 07 - 12, 2006
Location: Snowbird Resort, Snowbird, UT, USA
Sponsored by Genentech, Inc.
Summary of Meeting:
The Wnt/b-catenin pathway is a highly conserved signaling cascade that plays key roles during animal development. Deregulation of this pathway is often associated with cancer, especially in the human intestinal epithelium where hyperactive b-catenin is thought to initiate colorectal cancer. The basic outline of the Wnt/b-catenin cascade has been known since its discovery ten years ago by genetic analysis in Drosophila. How its components interact molecularly to transduce the Wnt signal from the plasma membrane to the nucleus is still poorly understood. Indeed, recent research in model systems has revealed new core components of this pathway. The main goal of this meeting is to promote insight into the molecular and cell-biological mechanisms of Wnt signal transduction in various cellular systems. Basic researchers and the pharmaceutical/biotechnology industry are invited to discuss how to exploit model systems and how to translate knowledge from these into drug development.
Scholarship Deadline: December 7 2005
Discounted Abstract Deadline: December 7 2005
Abstract Deadline: December 30 2005
Discounted Registration Deadline: February 7 2006
We gratefully acknowledge additional support for this conference from:
Cell Signaling Technology, Inc.Genentech, Inc.Novartis Institutes for BioMedical Research
We gratefully acknowledge the generous grant for this conference provided by:

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Grant No. 1R13 HD052386-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, April 07 | 3:00PM - 7:30PM
Registration
Room: Ballroom Lobby


Friday, April 07 | 6:30PM - 7:30PM
Refreshments
Room: Ballroom Mezzanine & Lobby


Friday, April 07 | 7:30PM - 8:30PM
Keynote Address
Room: Ballroom 2-3

Speaker 1 of 1
Philip A. Beachy, HHMI/Stanford University, USA
Hedgehog Signaling in Development and Disease

Saturday, April 08 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles Nest/Superior Lobby


Saturday, April 08 | 8:00AM - 11:00AM
Wnt Signaling at the Plasma Membrane
Room: Ballroom 2-3

Speaker 1 of 6
* Walter Birchmeier, Max Delbruck Center for Molecular Medicine, Germany

Saturday, April 08 | 8:00AM - 11:00AM
Wnt Signaling at the Plasma Membrane
Room: Ballroom 2-3

Speaker 2 of 6
Roeland Nusse, HHMI/Stanford University, USA
Wnt Proteins as Cell Fate Determinants

Saturday, April 08 | 8:00AM - 11:00AM
Wnt Signaling at the Plasma Membrane
Room: Ballroom 2-3

Speaker 3 of 6
Konrad Basler, University of Zurich, Switzerland
Wnt Signaling during Drosophila Development

Saturday, April 08 | 8:00AM - 11:00AM
Wnt Signaling at the Plasma Membrane
Room: Ballroom 2-3

Speaker 4 of 6
Xi He, Harvard Medical School, USA
Wnt coreceptor LRP6 phosphorylation and activation

Saturday, April 08 | 8:00AM - 11:00AM
Wnt Signaling at the Plasma Membrane
Room: Ballroom 2-3

Speaker 5 of 6
Christof Niehrs, Deutsches Krebsforschungszentrum, Germany
Casein Kinase 1 gamma Couples Wnt Receptor Activation to Cytoplasmic Signal Transduction

Saturday, April 08 | 8:00AM - 11:00AM
Wnt Signaling at the Plasma Membrane
Room: Ballroom 2-3

Speaker 6 of 6
Akira Kikuchi, Hiroshima University, Japan
Short Talk: Caveolin-Mediated Endocytosis of LRP6 is Required for Activation of Wnt/beta-Catenin Pathway

Saturday, April 08 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine & Lobby


Saturday, April 08 | 11:00AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Maybird


Saturday, April 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Maybird


Saturday, April 08 | 4:30PM - 5:00PM
Coffee Available
Room: Superior/Superior Lobby/Maybird


Saturday, April 08 | 5:00PM - 7:15PM
Wnt Signaling in the Cytoplasm and Nucleus
Room: Ballroom 2-3

Speaker 1 of 6
* Randall T. Moon, University of Washington School of Medicine, USA

Saturday, April 08 | 5:00PM - 7:15PM
Wnt Signaling in the Cytoplasm and Nucleus
Room: Ballroom 2-3

Speaker 2 of 6
Mariann Bienz, MRC Laboratory of Molecular Biology, UK
Wnt Signal Transduction by Dishevelled

Saturday, April 08 | 5:00PM - 7:15PM
Wnt Signaling in the Cytoplasm and Nucleus
Room: Ballroom 2-3

Speaker 3 of 6
William I. Weis, Stanford University, USA
Displacement of TLE/Groucho Proteins From Tcfs by beta-Catenin in Wnt-mediated Transcription Activation

Saturday, April 08 | 5:00PM - 7:15PM
Wnt Signaling in the Cytoplasm and Nucleus
Room: Ballroom 2-3

Speaker 4 of 6
Marian Waterman, University of California, Irvine, USA
TCF Diversity and Wnt Target Gene Regulation

Saturday, April 08 | 5:00PM - 7:15PM
Wnt Signaling in the Cytoplasm and Nucleus
Room: Ballroom 2-3

Speaker 5 of 6
Stefan Hoppler, University of Aberdeen, UK
Short Talk: Distinct Roles for Xenopus Tcf/Lef Genes in Mediating Specific Responses to Wnt/beta Catenin Signaling in Mesoderm Development

Saturday, April 08 | 5:00PM - 7:15PM
Wnt Signaling in the Cytoplasm and Nucleus
Room: Ballroom 2-3

Speaker 6 of 6
Xing Dai, University of California, Irvine, USA
Short Talk: Mouse Pygopus 2 is Required for Epithelial Morphogenesis and Controls the Amplitude of Canonical Wnt Signaling

Saturday, April 08 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Maybird


Saturday, April 08 | 7:30PM - 10:00PM
Poster Session 1
Room: Superior/Superior Lobby/Maybird


Sunday, April 09 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles Nest/Superior Lobby


Sunday, April 09 | 8:00AM - 11:00AM
Nuclear Responses of Wnt Signaling
Room: Ballroom 2-3

Speaker 1 of 6
* Mariann Bienz, MRC Laboratory of Molecular Biology, UK

Sunday, April 09 | 8:00AM - 11:00AM
Nuclear Responses of Wnt Signaling
Room: Ballroom 2-3

Speaker 2 of 6
Wenqing Xu, University of Washington, USA
Structural Analysis of beta-Catenin and beta-Catenin Complexes

Sunday, April 09 | 8:00AM - 11:00AM
Nuclear Responses of Wnt Signaling
Room: Ballroom 2-3

Speaker 3 of 6
Ken M. Cadigan, University of Michigan, USA
Short Talk: Transcriptional Activation by Wnt Signaling Requires CtBP and CBP

Sunday, April 09 | 8:00AM - 11:00AM
Nuclear Responses of Wnt Signaling
Room: Ballroom 2-3

Speaker 4 of 6
Walter Birchmeier, Max Delbruck Center for Molecular Medicine, Germany
Essential Role of BCL9-2 in the Switch between ß-Catenin’s Adhesive and Transcriptional Functions

Sunday, April 09 | 8:00AM - 11:00AM
Nuclear Responses of Wnt Signaling
Room: Ballroom 2-3

Speaker 5 of 6
Marc van de Wetering, Netherlands Institute for Developmental Biology, Netherlands
Short Talk: TCF4 Target Genes in Intestinal Cancer

Sunday, April 09 | 8:00AM - 11:00AM
Nuclear Responses of Wnt Signaling
Room: Ballroom 2-3

Speaker 6 of 6
Katherine A. Jones, The Salk Institute, USA
The APC Tumor Suppressor Counteracts ß-Catenin Activation and H3K4 Trimethylation at Wnt Target Genes

Sunday, April 09 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine & Lobby


Sunday, April 09 | 11:00AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Maybird


Sunday, April 09 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Maybird


Sunday, April 09 | 4:30PM - 5:00PM
Coffee Available
Room: Superior/Superior Lobby/Maybird


Sunday, April 09 | 5:00PM - 7:15PM
Non-Nuclear Responses of Wnt Signaling
Room: Ballroom 2-3

Speaker 1 of 6
* Roeland Nusse, HHMI/Stanford University, USA

Sunday, April 09 | 5:00PM - 7:15PM
Non-Nuclear Responses of Wnt Signaling
Room: Ballroom 2-3

Speaker 2 of 6
Elaine V. Fuchs, Rockefeller University, USA
Beta-Catenin Signaling during Skin Development

Sunday, April 09 | 5:00PM - 7:15PM
Non-Nuclear Responses of Wnt Signaling
Room: Ballroom 2-3

Speaker 3 of 6
Jeffrey D. Axelrod, Stanford University, USA
Frizzled feedback loop function during Planar Cell Polarity Signaling

Sunday, April 09 | 5:00PM - 7:15PM
Non-Nuclear Responses of Wnt Signaling
Room: Ballroom 2-3

Speaker 4 of 6
Sergei Y. Sokol, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Regulation of Epithelial Polarity by Lgl and Dishevelled

Sunday, April 09 | 5:00PM - 7:15PM
Non-Nuclear Responses of Wnt Signaling
Room: Ballroom 2-3

Speaker 5 of 6
Randall T. Moon, University of Washington School of Medicine, USA
Beta-Catenin-Independent Wnt Signaling

Sunday, April 09 | 5:00PM - 7:15PM
Non-Nuclear Responses of Wnt Signaling
Room: Ballroom 2-3

Speaker 6 of 6
Ping Chen, Emory University, USA
Short Talk: A Non-Canonical Wnt Pathway during Inner Ear Development

Sunday, April 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Maybird


Sunday, April 09 | 7:30PM - 10:00PM
Poster Session 2
Room: Superior/Superior Lobby/Maybird


Monday, April 10 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles Nest/Superior Lobby


Monday, April 10 | 8:00AM - 11:00AM
Wnt Signaling in Development
Room: Ballroom 2-3

Speaker 1 of 6
* Mark Peifer, University of North Carolina at Chapel Hill, USA

Monday, April 10 | 8:00AM - 11:00AM
Wnt Signaling in Development
Room: Ballroom 2-3

Speaker 2 of 6
Alan R. Clarke, Cardiff University, UK
Investigating The Wnt Pathway In Vivo Through Inactivation of Apc and c-Myc

Monday, April 10 | 8:00AM - 11:00AM
Wnt Signaling in Development
Room: Ballroom 2-3

Speaker 3 of 6
Thomas W. Holstein, Heidelberg University, Germany
Wnt Signaling in Cnidarians

Monday, April 10 | 8:00AM - 11:00AM
Wnt Signaling in Development
Room: Ballroom 2-3

Speaker 4 of 6
Kyung-Ah Kim, Nuvelo, Inc., USA
Beta-Catenin-Mediated Mitogenic Effect of R-spondin

Monday, April 10 | 8:00AM - 11:00AM
Wnt Signaling in Development
Room: Ballroom 2-3

Speaker 5 of 6
Tannishtha Reya, University of California, San Diego, USA
Molecular Regulation of Stem Cell Renewal and Regeneration

Monday, April 10 | 8:00AM - 11:00AM
Wnt Signaling in Development
Room: Ballroom 2-3

Speaker 6 of 6
Juan Carlos Izpisua-Belmonte, The Salk Institute for Biological Studies, USA
Short Talk: Wnt Signaling and Tissue Regeneration

Monday, April 10 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine & Lobby


Monday, April 10 | 11:00AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Maybird


Monday, April 10 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Maybird


Monday, April 10 | 4:30PM - 5:00PM
Coffee Available
Room: Superior/Superior Lobby/Maybird


Monday, April 10 | 5:00PM - 7:15PM
Wnt Signaling and Colorectal Cancer
Room: Ballroom 2-3

Speaker 1 of 6
* William I. Weis, Stanford University, USA

Monday, April 10 | 5:00PM - 7:15PM
Wnt Signaling and Colorectal Cancer
Room: Ballroom 2-3

Speaker 2 of 6
Raymond N. DuBois, Arizona State University, USA
Important Crosstalk between the COX-2--prostaglandin E2 and Wnt Signaling Pathways


Monday, April 10 | 5:00PM - 7:15PM
Wnt Signaling and Colorectal Cancer
Room: Ballroom 2-3

Speaker 3 of 6
David A. Jones, University of Utah, USA
Analysis of Colorectal Cancer Signaling Pathways by Microarray.

Monday, April 10 | 5:00PM - 7:15PM
Wnt Signaling and Colorectal Cancer
Room: Ballroom 2-3

Speaker 4 of 6
Owen J. Sansom, Beatson Institute of Cancer Research, UK
Short Talk: C-Myc is Essential for all the Intestinal Phenotypes (including tumourigenesis) caused by Apc Deficiency in vivo

Monday, April 10 | 5:00PM - 7:15PM
Wnt Signaling and Colorectal Cancer
Room: Ballroom 2-3

Speaker 5 of 6
Makoto Mark Taketo, Kyoto University Graduate School of Medicine, Japan
Wnt Signaling and Chromosomal Instability in Gastrointestinal Cancer

Monday, April 10 | 5:00PM - 7:15PM
Wnt Signaling and Colorectal Cancer
Room: Ballroom 2-3

Speaker 6 of 6
Christine Perret, Institut Cochin, France
Short Talk

Monday, April 10 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Maybird


Monday, April 10 | 7:30PM - 10:00PM
Poster Session 3
Room: Superior/Superior Lobby/Maybird


Tuesday, April 11 | 7:00AM - 8:00AM
Breakfast
Room: Golden Cliff/Eagles Nest/Superior Lobby


Tuesday, April 11 | 8:00AM - 11:00AM
Exploiting Model Systems
Room: Ballroom 2-3

Speaker 1 of 7
* Paul G. Polakis, Genentech, Inc., USA

Tuesday, April 11 | 8:00AM - 11:00AM
Exploiting Model Systems
Room: Ballroom 2-3

Speaker 2 of 7
Mark Peifer, University of North Carolina at Chapel Hill, USA
APC Family Proteins as Regulators of Wnt Signaling and the Cytoskeleton

Tuesday, April 11 | 8:00AM - 11:00AM
Exploiting Model Systems
Room: Ballroom 2-3

Speaker 3 of 7
Katherine E. Harris, University of California, Berkeley, USA
Short Talk: WNT5 Signaling Acts through the Atypical Receptor, DERAILED, to Guide Salivary Gland Migration

Tuesday, April 11 | 8:00AM - 11:00AM
Exploiting Model Systems
Room: Ballroom 2-3

Speaker 4 of 7
Laura W. Burrus, San Francisco State University, USA
Short Talk: Analysis of the Role of Porcupine/Palmitoylation in the Formation of the Wnt Gradient in the Chick Neural Tube

Tuesday, April 11 | 8:00AM - 11:00AM
Exploiting Model Systems
Room: Ballroom 2-3

Speaker 5 of 7
Hendrik C. Korswagen, Netherlands Institute for Developmental Biology, Netherlands
Wnt gradient formation requires retromer function in Wnt producing cells

Tuesday, April 11 | 8:00AM - 11:00AM
Exploiting Model Systems
Room: Ballroom 2-3

Speaker 6 of 7
Anna Bafico, Mount Sinai School of Medicine, USA
Short Talk: Characterization of Endogenous LRP6 Receptor Signaling in Model Cells and Breast/Ovarian Tumor Cells

Tuesday, April 11 | 8:00AM - 11:00AM
Exploiting Model Systems
Room: Ballroom 2-3

Speaker 7 of 7
Michel Aguet, Switzerland
Mouse Mutants of the Wnt Signaling Components Bcl9 and Pygo

Tuesday, April 11 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine & Lobby


Tuesday, April 11 | 4:30PM - 5:00PM
Coffee Available
Room: Superior/Superior Lobby/Maybird


Tuesday, April 11 | 5:00PM - 7:15PM
Drug Targets in the Wnt Signaling
Room: Ballroom 2-3

Speaker 1 of 7
* Makoto Mark Taketo, Kyoto University Graduate School of Medicine, Japan

Tuesday, April 11 | 5:00PM - 7:15PM
Drug Targets in the Wnt Signaling
Room: Ballroom 2-3

Speaker 2 of 7
Paul G. Polakis, Genentech, Inc., USA
Therapeutic intervention in the wnt signaling pathway.

Tuesday, April 11 | 5:00PM - 7:15PM
Drug Targets in the Wnt Signaling
Room: Ballroom 2-3

Speaker 3 of 7
David M. Jablons, University of California, San Francisco, USA
Developing Therapeutic Inhibitors of Wnt Signaling for Cancer Treatment: Antibodies to Small Molecules

Tuesday, April 11 | 5:00PM - 7:15PM
Drug Targets in the Wnt Signaling
Room: Ballroom 2-3

Speaker 4 of 7
Ramesh A. Shivdasani, Dana-Farber Cancer Institute, USA
Small-Molecule Antagonists of the beta-Catenin/TCF Interaction

Tuesday, April 11 | 5:00PM - 7:15PM
Drug Targets in the Wnt Signaling
Room: Ballroom 2-3

Speaker 5 of 7
Xiaoyan Michelle Zhang, Kyn Therapeutics, USA
Short Talk: Identification of Small Molecule Antagonists of Wnt Signaling

Tuesday, April 11 | 5:00PM - 7:15PM
Drug Targets in the Wnt Signaling
Room: Ballroom 2-3

Speaker 6 of 7
Mark Lee, Google, Inc., USA
Short Talk: Systemically Expressed Wnt Inhibitors as Probes for Wnt Pathway Functions in Cancer and Normal Adult Physiology

Tuesday, April 11 | 5:00PM - 7:15PM
Drug Targets in the Wnt Signaling
Room: Ballroom 2-3

Speaker 7 of 7
Jie Zheng, St. Jude Children's Research Hospital, USA
Short Talk: Structure-Based Investigation of Wnt Signaling Inhibitors

Tuesday, April 11 | 7:30PM - 8:30PM
Social Hour with Lite Bites
Room: Golden Cliff/Superior/Superior Lobby/Wasatch


Tuesday, April 11 | 8:00PM - 11:00PM
Entertainment
Room: Golden Cliff


Tuesday, April 11 | 8:00PM - 11:00PM
Cash Bar
Room: Golden Cliff


Wednesday, April 12 | 10:26AM - 10:26AM
Departure


*Session Chair.