Web Desc
Multi-Protein Complexes Involved in Cell Regulation
Organizer(s): Tom L. Blundell, Carol V. Robinson and Ralph A. Bradshaw
Date: August 18 - 23, 2006
Location: St. John's College - Cambridge, University of Cambridge, Cambridge, United Kingdom
Supported by The Director's Fund
Summary of Meeting:
As knowledge of protein structure advances it has become increasingly clear that protein interactions, both transient and stable, are far more extensive than originally appreciated and that the resulting complexes, with a very wide range of stabilities, form highly coordinated networks that govern biological processes. Understanding the fluxes of information that are transmitted by these protein-protein contacts is the essence of systems biology and is dependent, at least to a first approximation, on determining the structures of the proteins involved. There have been multiple approaches to this challenging problem ranging from crystallography and 2D NMR to hybridization and mass spectrometry. This meeting will assess the state of determining the structural and functional bases for protein-protein interactions with the view of exploring how these approaches augment and extend each other.
Scholarship Deadline: April 18 2006
Discounted Abstract Deadline: May 9 2006
Abstract Deadline: May 26 2006
Discounted Registration Deadline: June 19 2006
We gratefully acknowledge additional support for this conference from:
BBSRC - Biotechnology & Biological Sciences Research Council, UKRoyal Society of ChemistryUCB Celltech
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Friday, August 18 | 3:00PM - 7:30PM
Registration
Room: Foyer


Friday, August 18 | 6:30PM - 7:30PM
Refreshments
Room: Foyer


Friday, August 18 | 7:30PM - 9:30PM
Keynote Session
Room: Palmerston

Speaker 2 of 2
Carol V. Robinson, University of Oxford, UK
Multi-Protein Complexes – New Insights from Old Tools

Friday, August 18 | 7:30PM - 9:30PM
Keynote Session
Room: Palmerston

Speaker 1 of 2
Tom L. Blundell, University of Cambridge, UK
Multiprotein Assemblies: Structural Biology and Drug Discovery

Saturday, August 19 | 7:30AM - 8:30AM
Breakfast
Room: Buttery


Saturday, August 19 | 8:30AM - 11:30AM
Technological Approaches: Studying Macromolecular Interactio
ns and Dynamics I

Room: Palmerston

Speaker 4 of 4
James A. Wells, University of California, San Francisco, USA
Discovering Inhibitors of Protein Complexes

Saturday, August 19 | 8:30AM - 11:30AM
Technological Approaches: Studying Macromolecular Interactio
ns and Dynamics I

Room: Palmerston

Speaker 3 of 4
F. Ulrich Hartl, Max Planck Institute of Biochemistry, Germany
Protein Folding Machines: Interactions between Chaperones and their Clients

Saturday, August 19 | 8:30AM - 11:30AM
Technological Approaches: Studying Macromolecular Interactio
ns and Dynamics I

Room: Palmerston

Speaker 2 of 4
Keiichi Namba, Osaka University, Japan
Molecular Mechanisms of Swimming and Tumbling in Bacterial Motility

Saturday, August 19 | 8:30AM - 11:30AM
Technological Approaches: Studying Macromolecular Interactio
ns and Dynamics I

Room: Palmerston

Speaker 1 of 4
* Wolfgang P. Baumeister, Max Planck Institute of Biochemistry, Germany
Mapping Molecular Landscapes inside Cells by Cryoelectron Tomography

Saturday, August 19 | 9:40AM - 10:00AM
Coffee Break
Room: Foyer


Saturday, August 19 | 11:30AM - 12:00PM
Poster Setup
Room: Castlereagh Room/Foyer


Saturday, August 19 | 11:30AM - 12:30PM
Lunch
Room: The Hall


Saturday, August 19 | 12:30PM - 2:30PM
Poster Session 1
Room: Castlereagh Room/Foyer


Saturday, August 19 | 2:30PM - 4:30PM
Workshop 1: Dynamics and Regulation of Protein-Protein Inter
actions
Room: Palmerston

Speaker 8 of 8
Roopa Thapar, MD Anderson Cancer Center, USA
Allosteric Regulation of the SLBP-Histone mRNA Complex by Phosphorylation-Dependent Proline Isomerization

Saturday, August 19 | 2:30PM - 4:30PM
Workshop 1: Dynamics and Regulation of Protein-Protein Inter
actions
Room: Palmerston

Speaker 7 of 8
Angela Manegold Svendsen, Hagedorn Research Institute, Denmark
Kinetics of Insulin-Like Peptide 3 (INSL3) Binding to the Leucine-Rich Repeat-Containing G-Protein-Coupled Receptor 8 (LGR8): Evidence for Negative Cooperativity

Saturday, August 19 | 2:30PM - 4:30PM
Workshop 1: Dynamics and Regulation of Protein-Protein Inter
actions
Room: Palmerston

Speaker 6 of 8
Eric Underbakke, The Scripps Research Institute, USA
Illuminating Protein-Protein Interactions in Signal Transduction: Footprinting a Reconstituted Escherichia coli Chemotaxis Signaling Lattice

Saturday, August 19 | 2:30PM - 4:30PM
Workshop 1: Dynamics and Regulation of Protein-Protein Inter
actions
Room: Palmerston

Speaker 5 of 8
Alexis Gautreau, Centre National de la Recherche Scientifique, Institut Curie, France
Structural Conversion of Brick1 from a Free Trimer to a Single Subunit during the Assembly of the Wave Complex

Saturday, August 19 | 2:30PM - 4:30PM
Workshop 1: Dynamics and Regulation of Protein-Protein Inter
actions
Room: Palmerston

Speaker 4 of 8
Nadia Milech, PYC Therapeutics, Australia
Anti-Apoptotic Phylomer Peptides: Disruptors from Protein Folds

Saturday, August 19 | 2:30PM - 4:30PM
Workshop 1: Dynamics and Regulation of Protein-Protein Inter
actions
Room: Palmerston

Speaker 3 of 8
Ludovic Bannwarth, Centre National de la Recherche Scientifique, University Paris 6, France
Disabling a Protein Dimer with Rationally Designed Interface Peptidomimetics

Saturday, August 19 | 2:30PM - 4:30PM
Workshop 1: Dynamics and Regulation of Protein-Protein Inter
actions
Room: Palmerston

Speaker 2 of 8
* Marko Hyvönen, University of Cambridge, UK

Saturday, August 19 | 2:30PM - 4:30PM
Workshop 1: Dynamics and Regulation of Protein-Protein Inter
actions
Room: Palmerston

Speaker 1 of 8
* Nicholas J. Harmer, UK

Saturday, August 19 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Saturday, August 19 | 5:00PM - 7:00PM
Technological Approaches: Studying Macromolecular Interactio
ns and Dynamics II

Room: Palmerston

Speaker 2 of 4
Alexander Grishaev, NIDDK, National Institutes of Health, USA
Combining Solution NMR and Small Angle Scattering for Macromolecular Structure Determination

Saturday, August 19 | 5:00PM - 7:00PM
Technological Approaches: Studying Macromolecular Interactio
ns and Dynamics II

Room: Palmerston

Speaker 1 of 4
* Christopher M. Dobson, University of Cambridge, UK

Saturday, August 19 | 5:00PM - 7:00PM
Technological Approaches: Studying Macromolecular Interactio
ns and Dynamics II

Room: Palmerston

Speaker 3 of 4
Laura S. Itzhaki, Hutchison/MRC Research Centre, UK
Analysis of the assembly and dynamics of the multi-subunit ubiquitin ligase SCFSkp2

Saturday, August 19 | 5:00PM - 7:00PM
Technological Approaches: Studying Macromolecular Interactio
ns and Dynamics II

Room: Palmerston

Speaker 4 of 4
Elizabeth A. Komives, University of California, San Diego, USA
Dynamics of the NF-kappaB - IkappaB Interaction

Sunday, August 20 | 7:30AM - 8:30AM
Breakfast
Room: Buttery


Sunday, August 20 | 8:30AM - 11:30AM
Cell Surface Receptors
Room: Palmerston

Speaker 1 of 4
* John E. Ladbury, University College London, UK
Protein assemblies dictate specificity in tyrosine kinase-mediated signal transduction

Sunday, August 20 | 8:30AM - 11:30AM
Cell Surface Receptors
Room: Palmerston

Speaker 2 of 4
Colin W. Ward, University of New South Wales, Australia
Structural Insights into Signaling by the EGF and Insulin Receptor Families

Sunday, August 20 | 8:30AM - 11:30AM
Cell Surface Receptors
Room: Palmerston

Speaker 3 of 4
Nicholas J. Harmer, UK
Signaling Clusters in the Fibroblast Growth Factor System

Sunday, August 20 | 8:30AM - 11:30AM
Cell Surface Receptors
Room: Palmerston

Speaker 4 of 4
Johanna Mari Ivaska, University of Turku, Finland
Integrating Matrix Messages and Motility

Sunday, August 20 | 9:40AM - 10:00AM
Coffee Break
Room: Foyer


Sunday, August 20 | 11:30AM - 12:30PM
Lunch
Room: The Hall


Sunday, August 20 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Sunday, August 20 | 5:00PM - 7:00PM
Signaling Pathways
Room: Palmerston

Speaker 1 of 3
* Peter J. Parker, Cancer Research UK, UK
Multiple signalling pathways regulate the assembly of a PKCepsilon complex

Sunday, August 20 | 5:00PM - 7:00PM
Signaling Pathways
Room: Palmerston

Speaker 2 of 3
Yosef Yarden, Weizmann Institute of Science, Israel
Oncogenic growth factor signaling: a system perspective

Sunday, August 20 | 5:00PM - 7:00PM
Signaling Pathways
Room: Palmerston

Speaker 3 of 3
Bertrand Séraphin, Universite Paris 6, France
Structural and Functional Analysis of Protein Complexes Involved in Pathways Controlling Gene Expression

Monday, August 21 | 7:30AM - 8:30AM
Breakfast
Room: Buttery


Monday, August 21 | 8:30AM - 11:30AM
Intracellular Signaling - Structural Aspects
Room: Palmerston

Speaker 1 of 4
* Louise N. Johnson, University of Oxford, UK
Why Do Mammalian Cells Need More Than One Cyclin?

Monday, August 21 | 8:30AM - 11:30AM
Intracellular Signaling - Structural Aspects
Room: Palmerston

Speaker 2 of 4
John Kuriyan, University of California, Berkeley, USA
Structural Insights Into the Regulation of Tyrosine Kinase Signaling

Monday, August 21 | 8:30AM - 11:30AM
Intracellular Signaling - Structural Aspects
Room: Palmerston

Speaker 3 of 4
David Barford, Institute of Cancer Research, UK
Function and Structure of the Anaphase Promoting Complex, a Multi-Subunit Ubiquitin Ligase

Monday, August 21 | 8:30AM - 11:30AM
Intracellular Signaling - Structural Aspects
Room: Palmerston

Speaker 4 of 4
Stephen W. Fesik, Vanderbilt University School of Medicine, USA
Apoptosis: Structural Biology and Drug Design

Monday, August 21 | 9:40AM - 10:00AM
Coffee Break
Room: Foyer


Monday, August 21 | 11:30AM - 12:30PM
Lunch
Room: The Hall


Monday, August 21 | 11:30AM - 12:00PM
Poster Setup
Room: Castlereagh Room/Foyer


Monday, August 21 | 12:30PM - 2:30PM
Poster Session 2
Room: Castlereagh Room/Foyer


Monday, August 21 | 2:30PM - 4:30PM
Workshop 2: Diverse Methods for the Study of Protein-Protein
Interactions
Room: Palmerston

Speaker 1 of 9
* Jane Clarke, University of Cambridge, UK

Monday, August 21 | 2:30PM - 4:30PM
Workshop 2: Diverse Methods for the Study of Protein-Protein
Interactions
Room: Palmerston

Speaker 2 of 9
Ananth Krupa, London Research Institute, Cancer Research UK, UK
Substrate Recognition by CDKs: Role of Consensus Sequence Motifs and Implications for Identification of Novel Substrates

Monday, August 21 | 2:30PM - 4:30PM
Workshop 2: Diverse Methods for the Study of Protein-Protein
Interactions
Room: Palmerston

Speaker 3 of 9
Yingnan Zhang, Genentech, Inc., USA
Genome-Wide Analysis of the PDZ Domain Family

Monday, August 21 | 2:30PM - 4:30PM
Workshop 2: Diverse Methods for the Study of Protein-Protein
Interactions
Room: Palmerston

Speaker 4 of 9
Jacqui M. Matthews, University of Sydney, Australia
The Assembly Of A Transcriptional Complex

Monday, August 21 | 2:30PM - 4:30PM
Workshop 2: Diverse Methods for the Study of Protein-Protein
Interactions
Room: Palmerston

Speaker 5 of 9
Ricardo M. Biondi, University of Saarland, Germany
Modulation of Phosphorylation-Dependent Protein Kinase Conformational Transitions with Low Molecular Weight Compounds

Monday, August 21 | 2:30PM - 4:30PM
Workshop 2: Diverse Methods for the Study of Protein-Protein
Interactions
Room: Palmerston

Speaker 6 of 9
Narayanaswamy Srinivasan, Indian Institute of Science, India
Interaction Interfaces of Protein Domains are not Topologically Equivalent Across Families within Superfamilies: Evolutionary Dynamics and Implications for Metabolic and Signalling Pathways

Monday, August 21 | 2:30PM - 4:30PM
Workshop 2: Diverse Methods for the Study of Protein-Protein
Interactions
Room: Palmerston

Speaker 7 of 9
Carla F. Cervantes, University of California, San Diego, USA
Dynamics of IkappaBalpha Probed by NMR

Monday, August 21 | 2:30PM - 4:30PM
Workshop 2: Diverse Methods for the Study of Protein-Protein
Interactions
Room: Palmerston

Speaker 8 of 9
Franca Fraternali, King's College London, UK
Molecular Dynamics Study of Hydration Properties of Prion Proteins

Monday, August 21 | 2:30PM - 4:30PM
Workshop 2: Diverse Methods for the Study of Protein-Protein
Interactions
Room: Palmerston

Speaker 9 of 9
Lan Huang, University of California, Irvine, USA
Proteomic Analysis of Human 26S Proteasome Complex Using Mass Spectrometry

Monday, August 21 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Monday, August 21 | 5:00PM - 7:00PM
Cellular Processes
Room: Palmerston

Speaker 1 of 3
* Dale B. Wigley, Institute of Cancer Research, UK
Crystal Structure of RecBCD: A Machine for Processing DNA Breaks

Monday, August 21 | 5:00PM - 7:00PM
Cellular Processes
Room: Palmerston

Speaker 2 of 3
Andrej Sali, University of California, San Francisco, USA
Modeling the Structures of Proteins and Macromolecular Assemblies

Monday, August 21 | 5:00PM - 7:00PM
Cellular Processes
Room: Palmerston

Speaker 3 of 3
Marko Hyvönen, University of Cambridge, UK
Extracellular Regulation of TGFbeta Family Growth Factors

Tuesday, August 22 | 7:30AM - 8:30AM
Breakfast
Room: Buttery


Tuesday, August 22 | 8:30AM - 11:30AM
Computational Analyses: Docking and Protein-Protein Interact
ions

Room: Palmerston

Speaker 1 of 4
* Janet M. Thornton, European Bioinformatics Institute, UK
Structure to Function: Recognising Interaction Partners

Tuesday, August 22 | 8:30AM - 11:30AM
Computational Analyses: Docking and Protein-Protein Interact
ions

Room: Palmerston

Speaker 2 of 4
Robert B. Russell, University of Heidelberg, Germany
Predicting Molecular Details for Protein-Interaction Networks

Tuesday, August 22 | 8:30AM - 11:30AM
Computational Analyses: Docking and Protein-Protein Interact
ions

Room: Palmerston

Speaker 3 of 4
Joël Janin, CNRS/Université Paris-Sud, France
Protein-protein recognition sites: structural analysis and prediction

Tuesday, August 22 | 8:30AM - 11:30AM
Computational Analyses: Docking and Protein-Protein Interact
ions

Room: Palmerston

Speaker 4 of 4
Juan Fernandez-Recio, Institute of Biomedical Research (IRB-PCB), Spain
Computational Protein-Protein Docking: Present and Future Challenges

Tuesday, August 22 | 9:40AM - 10:00AM
Coffee Break
Room: Foyer


Tuesday, August 22 | 11:30AM - 12:30PM
Lunch
Room: The Hall


Tuesday, August 22 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Tuesday, August 22 | 5:00PM - 7:00PM
Protein Folding, Aggregation and Diseases
Room: Palmerston

Speaker 1 of 3
* Christopher M. Dobson, University of Cambridge, UK
Protein Folding , Molecular Evolution and Human Disease

Tuesday, August 22 | 5:00PM - 7:00PM
Protein Folding, Aggregation and Diseases
Room: Palmerston

Speaker 2 of 3
David Eisenberg, University of California, Los Angeles, USA
Structures of Febryl-Forming Segments from Amyloid Proteins

Tuesday, August 22 | 5:00PM - 7:00PM
Protein Folding, Aggregation and Diseases
Room: Palmerston

Speaker 3 of 3
Sheena E. Radford, University of Leeds, UK
Life on a knife edge: Tipping the balance between folding and aggregation

Tuesday, August 22 | 7:00PM - 8:00PM
Dinner
Room: The Hall


Tuesday, August 22 | 8:00PM - 11:00PM
Entertainment
Room: The Hall


Tuesday, August 22 | 8:00PM - 11:00PM
Cash Bar
Room: College Bar


Wednesday, August 23 | 10:26AM - 10:26AM
Departure


*Session Chair.