Web Desc
Gut Hormones and Other Regulators of Appetite, Satiety and Energy Expenditure
Organizer(s): Stephen R. Bloom and Roger D. Cone
Date: March 02 - 07, 2006
Location: Eldorado Hotel & Spa, Santa Fe, NM, USA
Sponsored by Lilly Research Laboratories
For important information on the coronavirus, please click here
Summary of Meeting:
Circulating factors are important in regulating energy balance. It has long been recognized that the adipose hormone, leptin, reduces food intake by specific CNS pathways. Gut hormones have also been shown to be major regulators of appetite, acting both in the brainstem and hypothalamus. In addition, they have been found to markedly influence energy expenditure. Obesity is associated with a reduced gut hormone release but the mechanism is unknown. In man, this change may perpetuate or contribute to obesity. This meeting will address the physiological importance of circulating hormones in the regulation of energy balance. We will explore the mechanisms involved, their disturbance in obesity, and therapeutic possibilities.
Scholarship Deadline: November 2 2005
Discounted Abstract Deadline: November 2 2005
Abstract Deadline: November 23 2005
Discounted Registration Deadline: January 3 2006
We gratefully acknowledge additional support for this conference from:
Diagnostics Systems Laboratories, Inc. (DSL)Lilly Research LaboratoriesNovartis Institutes for BioMedical ResearchResearch Diets, Inc.
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Amylin Pharmaceuticals Inc.

P1vital
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1R13 DK074282-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Thursday, March 02 | 3:00PM - 7:00PM
Registration
Room: South Concourse


Thursday, March 02 | 6:30PM - 7:30PM
Refreshments
Room: Eldorado Court/Sunset Room


Thursday, March 02 | 7:30PM - 8:30PM
Keynote Address
Room: Anasazi Ballroom

Speaker 1 of 2
* Roger D. Cone, University of Michigan, USA
Introductory Remarks

Thursday, March 02 | 7:30PM - 8:30PM
Keynote Address
Room: Anasazi Ballroom

Speaker 2 of 2
Stephen O'Rahilly, University of Cambridge, UK
Genetic Disorders of Energy Balance

Friday, March 03 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Friday, March 03 | 8:00AM - 11:00AM
CNS Appetite Circuits
Room: Anasazi Ballroom

Speaker 1 of 6
* Andrew D. Howard, Merck Research Laboratories, USA

Friday, March 03 | 8:00AM - 11:00AM
CNS Appetite Circuits
Room: Anasazi Ballroom

Speaker 2 of 6
Hans Rudolf Berthoud, Pennington Biomedical Research Center, USA
Brainstem Integration of Short- and Long-Term Satiety Signals

Friday, March 03 | 8:00AM - 11:00AM
CNS Appetite Circuits
Room: Anasazi Ballroom

Speaker 3 of 6
Joel K. Elmquist, University of Texas Southwestern Medical Center, USA
CNS Circuits Underlying the Coordinated Control of Body Weight and Glucose Homeostasis

Friday, March 03 | 8:00AM - 11:00AM
CNS Appetite Circuits
Room: Anasazi Ballroom

Speaker 4 of 6
Roger D. Cone, University of Michigan, USA
Development of the Zebrafish as a System for the Genetic Analysis of Energy Homeostasis

Friday, March 03 | 8:00AM - 11:00AM
CNS Appetite Circuits
Room: Anasazi Ballroom

Speaker 5 of 6
Maribel Rios, Tufts University School of Medicine, USA
Short Talk: Brain-derived Neurotrophic Factor as a Regulator of Energy Balance

Friday, March 03 | 8:00AM - 11:00AM
CNS Appetite Circuits
Room: Anasazi Ballroom

Speaker 6 of 6
William F. Colmers, University of Alberta, Canada
Short Talk: Development of Energy-Balance-Sensitive Parvocellular eurons in Rat Paraventricula Hypothalamus (PVN)

Friday, March 03 | 9:20AM - 9:40AM
Coffee Break
Room: South Concourse


Friday, March 03 | 11:00AM - 1:00PM
Poster Setup
Room: Sunset Room


Friday, March 03 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room


Friday, March 03 | 4:30PM - 5:00PM
Coffee Available
Room: South Concourse


Friday, March 03 | 5:00PM - 7:00PM
Ghrelin
Room: Anasazi Ballroom

Speaker 1 of 5
* Yvette Taché, University of California, Los Angeles, USA

Friday, March 03 | 5:00PM - 7:00PM
Ghrelin
Room: Anasazi Ballroom

Speaker 2 of 5
David E. Cummings, University of Washington, USA
Roles for Ghrelin in the Regulation of Energy Balance and Glucose Homeostasis

Friday, March 03 | 5:00PM - 7:00PM
Ghrelin
Room: Anasazi Ballroom

Speaker 3 of 5
Matthias H. Tschöp, Helmholtz Zentrum München and Technische Universität München, Germany
Ghrelin

Friday, March 03 | 5:00PM - 7:00PM
Ghrelin
Room: Anasazi Ballroom

Speaker 4 of 5
Andrew D. Howard, Merck Research Laboratories, USA
Pharmacology of Ghrelin

Friday, March 03 | 5:00PM - 7:00PM
Ghrelin
Room: Anasazi Ballroom

Speaker 5 of 5
Yukari Date, University of Miyazaki, Japan
Short Talk: Stomach-Derived Ghrelin’s Communication with the Brain

Friday, March 03 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Friday, March 03 | 7:30PM - 10:00PM
Poster Session 1
Room: Sunset Room


Saturday, March 04 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Saturday, March 04 | 8:00AM - 11:15AM
GLP-1 and Oxyntomodulin
Room: Anasazi Ballroom

Speaker 1 of 7
* David E. Cummings, University of Washington, USA

Saturday, March 04 | 8:00AM - 11:15AM
GLP-1 and Oxyntomodulin
Room: Anasazi Ballroom

Speaker 2 of 7
Jens Juul Holst, University of Copenhagen the Panum Institute, Denmark
Glucagon-Like Peptide 1: Effects in Diabetes and on Body Weight

Saturday, March 04 | 8:00AM - 11:15AM
GLP-1 and Oxyntomodulin
Room: Anasazi Ballroom

Speaker 3 of 7
Nazneen Aziz, Point Therapeutics, USA
Short Talk: Glucose, Triglyceride Lowering and Other Antidiabetic Activity Of PT-630, a Long-Acting DPP-4 Inhibitor, in Acute and Chronic Studies

Saturday, March 04 | 8:00AM - 11:15AM
GLP-1 and Oxyntomodulin
Room: Anasazi Ballroom

Speaker 4 of 7
Andrew A. Young, Intarcia Therapeutics Inc, USA
Exenatide for Diabetes

Saturday, March 04 | 8:00AM - 11:15AM
GLP-1 and Oxyntomodulin
Room: Anasazi Ballroom

Speaker 5 of 7
Stephen R. Bloom, Imperial College London, UK
Oxyntomodulin

Saturday, March 04 | 8:00AM - 11:15AM
GLP-1 and Oxyntomodulin
Room: Anasazi Ballroom

Speaker 6 of 7
Carolyn M. Jodka, Amylin Pharmaceuticals Inc., USA
Short Talk: Anti-Obesity Effects of Peripherally Administered Oxyntomodulin in High Fat-Fed Mice

Saturday, March 04 | 8:00AM - 11:15AM
GLP-1 and Oxyntomodulin
Room: Anasazi Ballroom

Speaker 7 of 7
Yvette Taché, University of California, Los Angeles, USA
Nibbling at CRF Receptor Control of Feeding and Gastric Emptying in Rodents

Saturday, March 04 | 9:20AM - 9:40AM
Coffee Break
Room: South Concourse


Saturday, March 04 | 11:15AM - 1:00PM
Poster Setup
Room: Sunset Room


Saturday, March 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Sunset Room


Saturday, March 04 | 4:30PM - 5:00PM
Coffee Available
Room: South Concourse


Saturday, March 04 | 5:00PM - 7:00PM
Other Hormones
Room: Anasazi Ballroom

Speaker 1 of 6
* Sadaf Farooqi, University of Cambridge, UK

Saturday, March 04 | 5:00PM - 7:00PM
Other Hormones
Room: Anasazi Ballroom

Speaker 2 of 6
Rachel L. Batterham, University College London, UK
Macronutrients and Satiety

Saturday, March 04 | 5:00PM - 7:00PM
Other Hormones
Room: Anasazi Ballroom

Speaker 3 of 6
Thue W. Schwartz, University of Copenhagen, Denmark
Obestatin a Peptide Fragment From the Ghrelin Precursor And GPR39 a Constitutively Active Member of the Ghrelin Family of 7TM Receptors

Saturday, March 04 | 5:00PM - 7:00PM
Other Hormones
Room: Anasazi Ballroom

Speaker 4 of 6
Ilia G. Halatchev, Vollum Institute, USA
Short Talk: Inhibition of Food Intake by PYY3–36 is Independent of NPY/AgRP and the Arcuate Nucleus

Saturday, March 04 | 5:00PM - 7:00PM
Other Hormones
Room: Anasazi Ballroom

Speaker 5 of 6
Aaron Hsueh, Stanford University, USA
Obestatin and its Receptor

Saturday, March 04 | 5:00PM - 7:00PM
Other Hormones
Room: Anasazi Ballroom

Speaker 6 of 6
Linda Rinaman, Florida State University, USA
Satiety vs. Nimiety: The Role of Central Oxytocin

Saturday, March 04 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Saturday, March 04 | 7:30PM - 10:00PM
Poster Session 2
Room: Sunset Room


Sunday, March 05 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Sunday, March 05 | 8:00AM - 11:15AM
CNS Pathways
Room: Anasazi Ballroom

Speaker 1 of 7
* Joel K. Elmquist, University of Texas Southwestern Medical Center, USA

Sunday, March 05 | 8:00AM - 11:15AM
CNS Pathways
Room: Anasazi Ballroom

Speaker 2 of 7
Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
AMPK

Sunday, March 05 | 8:00AM - 11:15AM
CNS Pathways
Room: Anasazi Ballroom

Speaker 3 of 7
Rexford S. Ahima, University of Pennsylvania, USA
Role of Adiponectin in Energy and Glucose Homeostasis

Sunday, March 05 | 8:00AM - 11:15AM
CNS Pathways
Room: Anasazi Ballroom

Speaker 4 of 7
Herbert Herzog, Garvan Institute, Australia
Lessons from NPY and Y-Receptor Knockout Mice

Sunday, March 05 | 8:00AM - 11:15AM
CNS Pathways
Room: Anasazi Ballroom

Speaker 5 of 7
Gavin A. Bewick, Kings College London, UK
Short Talk: Phenotypic Characterisation of Mice Lacking AgRP Neurons

Sunday, March 05 | 8:00AM - 11:15AM
CNS Pathways
Room: Anasazi Ballroom

Speaker 6 of 7
Sebastien G. Bouret, Inserm U1172, France
Short Talk: Development of Peptidergic Projection Pathways from the Arcuate Nucleus is Mediated Differentially through Activation of ObRb Signaling Pathways

Sunday, March 05 | 8:00AM - 11:15AM
CNS Pathways
Room: Anasazi Ballroom

Speaker 7 of 7
Randy J. Seeley, University of Michigan, USA
A Novel Role for the Fuel-Sensitive Kinase mTOR in the Hypothalamic Regulation of Energy Balance

Sunday, March 05 | 9:20AM - 9:40AM
Coffee Break
Room: South Concourse


Sunday, March 05 | 4:30PM - 5:00PM
Coffee Available
Room: South Concourse


Sunday, March 05 | 5:00PM - 7:00PM
Short Talk Session
Room: Anasazi Ballroom

Speaker 1 of 7
* Rachel L. Batterham, University College London, UK

Sunday, March 05 | 5:00PM - 7:00PM
Short Talk Session
Room: Anasazi Ballroom

Speaker 2 of 7
Masoud Ghamari-Langroudi, Vanderbilt University, USA
Regulation of Firing Activity of Melanocortin 4 Receptor Expressing Neurons of Mouse Paraventricular Nucleus: Convergence of Signals of Adiposity


Sunday, March 05 | 5:00PM - 7:00PM
Short Talk Session
Room: Anasazi Ballroom

Speaker 3 of 7
Kirsty L. Smith, Imperial College London, UK
Twenty Four Hour Metabolic Profiles of ICV Administered Hypothalamic Neuropeptides

Sunday, March 05 | 5:00PM - 7:00PM
Short Talk Session
Room: Anasazi Ballroom

Speaker 4 of 7
Christian E. Elling, Lundbeck Foundation, Denmark
Short Talk: Selective Y2 Versus Selective Y4 And Combined Y2-Y4 Receptor Agonists for Treatment of Obesity

Sunday, March 05 | 5:00PM - 7:00PM
Short Talk Session
Room: Anasazi Ballroom

Speaker 5 of 7
Ofer Reizes, Cleveland Clinic Foundation, USA
Ghrelin Antagonist is Efficacious in Lean but not Obese Rodents

Sunday, March 05 | 5:00PM - 7:00PM
Short Talk Session
Room: Anasazi Ballroom

Speaker 6 of 7
Birgitte Sloth, Royal Veterinary and Agricultural University, Denmark
The Effect of PYY1-36 and PYY3-36 on Appetite, Energy Intake and Energy Expenditure in Obese and Lean Subjects

Sunday, March 05 | 5:00PM - 7:00PM
Short Talk Session
Room: Anasazi Ballroom

Speaker 7 of 7
Judith Körner, Columbia University, USA
Differential Effects of Gastric Banding and Roux-en-Y Gastric Bypass on Fasting and Post-Prandial Plasma Peptide YY, Ghrelin, Leptin and Insulin Concentrations

Sunday, March 05 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Monday, March 06 | 7:00AM - 8:00AM
Breakfast
Room: Eldorado Court


Monday, March 06 | 8:00AM - 11:15AM
Novel Appetite Regulators
Room: Anasazi Ballroom

Speaker 1 of 7
* Hans Rudolf Berthoud, Pennington Biomedical Research Center, USA

Monday, March 06 | 8:00AM - 11:15AM
Novel Appetite Regulators
Room: Anasazi Ballroom

Speaker 2 of 7
Jonathan R. Seckl, University of Edinburgh School of Clinical Sciences & Community Health, UK
11beta-Hydroxysteroid Dehydrogenase Type 1: From Metabolic Syndrome to Memory

Monday, March 06 | 8:00AM - 11:15AM
Novel Appetite Regulators
Room: Anasazi Ballroom

Speaker 3 of 7
Daniele Piomelli, University of California, Irvine, USA
Lipid Mediators that Regulate Feeding

Monday, March 06 | 8:00AM - 11:15AM
Novel Appetite Regulators
Room: Anasazi Ballroom

Speaker 4 of 7
Marie Björnholm, Karolinska Institutet, Sweden
Short Talk: Mice Lacking Inhibitory Leptin Receptor Signals are Lean with Normal Endocrine Function

Monday, March 06 | 8:00AM - 11:15AM
Novel Appetite Regulators
Room: Anasazi Ballroom

Speaker 5 of 7
Neel S. Singhal, University of Pennsylvania School of Medicine, USA
Short Talk: Divergent Effects of Resistin and Leptin on Energy and Glucose Homeostasis

Monday, March 06 | 8:00AM - 11:15AM
Novel Appetite Regulators
Room: Anasazi Ballroom

Speaker 6 of 7
Harvey J. Grill, University of Pennsylvania, USA
Contributions of Caudal Brainstem to Responses to GI Signals and to a Distributed Neural Control of Energy Homeostasis

Monday, March 06 | 8:00AM - 11:15AM
Novel Appetite Regulators
Room: Anasazi Ballroom

Speaker 7 of 7
Sadaf Farooqi, University of Cambridge, UK
Role of Neurotrophins in the Regulation of Human Appetite

Monday, March 06 | 9:20AM - 9:40AM
Coffee Break
Room: South Concourse


Monday, March 06 | 4:30PM - 5:00PM
Coffee Available
Room: South Concourse


Monday, March 06 | 5:00PM - 7:00PM
Therapeutic Interest
Room: Anasazi Ballroom

Speaker 1 of 4
* Jonathan R. Seckl, University of Edinburgh School of Clinical Sciences & Community Health, UK

Monday, March 06 | 5:00PM - 7:00PM
Therapeutic Interest
Room: Anasazi Ballroom

Speaker 2 of 4
Colin T. Dourish, P1vital, UK
Serotonergic Circuits – Therapeutic Possibilities

Monday, March 06 | 5:00PM - 7:00PM
Therapeutic Interest
Room: Anasazi Ballroom

Speaker 3 of 4
Rick Costantino, Nastech Pharmaceutical Company Company Inc., USA
Peptides as Therapeutics – Novel Mechanisms for Delivery

Monday, March 06 | 5:00PM - 7:00PM
Therapeutic Interest
Room: Anasazi Ballroom

Speaker 4 of 4
Caroline Small, Imperial College London, UK
The Obesity Market – Do peptides such as PYY offer a viable approach?

Monday, March 06 | 8:00PM - 9:00PM
Social Hour with Lite Bites
Room: Eldorado Court/Sunset Room


Monday, March 06 | 8:00PM - 11:00PM
Entertainment
Room: Eldorado Court/Sunset Room


Monday, March 06 | 9:00PM - 11:00PM
Cash Bar
Room: Eldorado Court/Sunset Room


Tuesday, March 07 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.