Metabolomics: From Bioenergetics to Apoptosis

Organizer(s): Craig B. Thompson, David G. Nicholls and Anne N. Murphy

Supported by The Director's Fund

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Summary of Meeting:

The bioenergetic status of a cell plays a critical role in determining its ability to survive. Cells unable to maintain sufficient ATP production to support essential cellular processes die passively by necrosis. In contrast, apoptosis is an organized and energy-dependent form of cell death. Recently, genes involved in bioenergetic control and/or mitochondrial function have been implicated in the regulation of apoptosis. The purpose of this meeting is to define the role of bioenergetics in determining a cell's susceptibility to apoptosis. Among the issues to be considered are the following: the contribution of metabolic regulators (Akt, PGC-1, and HIF-1a) to mitochondrial function and apoptotic susceptibility, the role of bioenergetic sensing pathways (AMPK, TOR, autophagy) in modulating apoptotic sensitivity, and how mitochondrial function influences the contributions of calcium, oxidative stress, and Bcl-2 family proteins to apoptotic regulation. The meeting will focus on how these relationships may contribute to understanding the pathogenesis and improving the treatment of a wide variety of disorders including neurodegenerative syndromes, cancer, and cardiovascular disease.

Scholarship Deadline: December 1 2005

Discounted Abstract Deadline: December 1 2005

Abstract Deadline: December 27 2005

Discounted Registration Deadline: February 2 2006

We gratefully acknowledge additional support for this conference from:

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Metabolomics

We gratefully acknowledge the generous grant for this conference provided by:

National Institute on Aging (NIA)
Grant No. 1R13 AG027645-01

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