Web Desc
Metabolomics: From Bioenergetics to Apoptosis
Organizer(s): Craig B. Thompson, David G. Nicholls and Anne N. Murphy
Date: April 02 - 07, 2006
Location: Snowbird Resort, Snowbird, UT, USA
Supported by The Director's Fund
For important information on the coronavirus, please click here
Summary of Meeting:
The bioenergetic status of a cell plays a critical role in determining its ability to survive. Cells unable to maintain sufficient ATP production to support essential cellular processes die passively by necrosis. In contrast, apoptosis is an organized and energy-dependent form of cell death. Recently, genes involved in bioenergetic control and/or mitochondrial function have been implicated in the regulation of apoptosis. The purpose of this meeting is to define the role of bioenergetics in determining a cell's susceptibility to apoptosis. Among the issues to be considered are the following: the contribution of metabolic regulators (Akt, PGC-1, and HIF-1a) to mitochondrial function and apoptotic susceptibility, the role of bioenergetic sensing pathways (AMPK, TOR, autophagy) in modulating apoptotic sensitivity, and how mitochondrial function influences the contributions of calcium, oxidative stress, and Bcl-2 family proteins to apoptotic regulation. The meeting will focus on how these relationships may contribute to understanding the pathogenesis and improving the treatment of a wide variety of disorders including neurodegenerative syndromes, cancer, and cardiovascular disease.
Scholarship Deadline: December 1 2005
Discounted Abstract Deadline: December 1 2005
Abstract Deadline: December 27 2005
Discounted Registration Deadline: February 2 2006
We gratefully acknowledge additional support for this conference from:
Novartis Institutes for BioMedical Research
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Metabolomics
We gratefully acknowledge the generous grant for this conference provided by:

National Institute on Aging (NIA)
Grant No. 1R13 AG027645-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Program

Sunday, April 02 | 3:00PM - 7:30PM
Registration
Room: Ballroom Lobby


Sunday, April 02 | 6:30PM - 7:30PM
Refreshments
Room: Ballroom Mezzanine & Lobby


Sunday, April 02 | 7:30PM - 8:30PM
Keynote Address
Room: Ballroom 2-3

Speaker 1 of 1
Douglas C. Wallace, Children's Hospital of Philadelphia, USA
Mitochondrial and Evolutionary Medicine: A Paradigm of Metabolic and Degenerative Diseases, Cancer and Aging


Monday, April 03 | 7:00AM - 8:00AM
Breakfast
Room: Wasatch / Superior Lobby


Monday, April 03 | 8:00AM - 11:15AM
Metabolic Regulation of Mitochondrial Function and Apoptosis
Room: Ballroom 2-3

Speaker 1 of 6
* Morris J. Birnbaum, Pfizer Inc., USA
Akt Control of Glucose Metabolism and Apoptosis

Monday, April 03 | 8:00AM - 11:15AM
Metabolic Regulation of Mitochondrial Function and Apoptosis
Room: Ballroom 2-3

Speaker 2 of 6
Don W. Cleveland, University of California, San Diego, USA
Mechanisms and Treatment of ALS: Selective Mitochondrial Targeting of Misfolded Mutant Protein

Monday, April 03 | 8:00AM - 11:15AM
Metabolic Regulation of Mitochondrial Function and Apoptosis
Room: Ballroom 2-3

Speaker 3 of 6
Pere Puigserver, Dana-Farber Cancer Institute, Harvard Medical School, USA
Nutrient-Regulated Transcriptional Responses Linked to Glucose and Lipid Metabolism

Monday, April 03 | 8:00AM - 11:15AM
Metabolic Regulation of Mitochondrial Function and Apoptosis
Room: Ballroom 2-3

Speaker 4 of 6
J. Marie Hardwick, Johns Hopkins University Schools of Public Health and Medicine, USA
Bcl-xL Modulates Mitochondrial Structure and Energetics

Monday, April 03 | 8:00AM - 11:15AM
Metabolic Regulation of Mitochondrial Function and Apoptosis
Room: Ballroom 2-3

Speaker 5 of 6
Qiang Tong, Baylor College of Medicine, USA
Short Talk: Metabolic Regulation of SIRT3, A Mitochondrial NAD-Dependent Deacetylase

Monday, April 03 | 8:00AM - 11:15AM
Metabolic Regulation of Mitochondrial Function and Apoptosis
Room: Ballroom 2-3

Speaker 6 of 6
Ioanna Papandreou, Ohio State University, USA
Short Talk: Hif-1 Down-Regulates Mitochondrial Oxygen Consumption in Tumors, Modifying Sensitivity to Oxygen-Dependent Therapies

Monday, April 03 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine & Lobby


Monday, April 03 | 11:15AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Maybird


Monday, April 03 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Maybird


Monday, April 03 | 4:30PM - 5:00PM
Coffee Available
Room: Superior/Superior Lobby/Maybird


Monday, April 03 | 5:00PM - 7:15PM
Bioenergetic Sensing Pathways
Room: Ballroom 2-3

Speaker 1 of 4
George Thomas, University of Cincinnati, USA
The Role of Nutrients in TSC1/2-RHEB Mediated mTOR Pathway

Monday, April 03 | 5:00PM - 7:15PM
Bioenergetic Sensing Pathways
Room: Ballroom 2-3

Speaker 2 of 4
* Lewis C. Cantley, Weill Cornell Medicine, USA
LKB1 and AMP Kinase Link Bioenergetic Status to Apoptosis and Growth

Monday, April 03 | 5:00PM - 7:15PM
Bioenergetic Sensing Pathways
Room: Ballroom 2-3

Speaker 3 of 4
Narayan G. Avadhani, University of Pennsylvania, USA
Signaling from Mitochondria to Nucleus: A Mitochondrial Stress Response

Monday, April 03 | 5:00PM - 7:15PM
Bioenergetic Sensing Pathways
Room: Ballroom 2-3

Speaker 4 of 4
Beth Levine, University of Texas Southwestern Medical Center, USA
Autophagy, Cell Death and Bioenergetics


Monday, April 03 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Maybird


Monday, April 03 | 7:30PM - 10:00PM
Poster Session 1
Room: Superior/Superior Lobby/Maybird


Tuesday, April 04 | 7:00AM - 8:00AM
Breakfast
Room: Wasatch / Superior Lobby


Tuesday, April 04 | 8:00AM - 11:15AM
Mitochondrial Bioenergetics and the Induction of Apoptosis
Room: Ballroom 2-3

Speaker 1 of 6
Martin Crompton, University College London, UK
The Mitochondiral Transition Pore and its Role in Cell Death

Tuesday, April 04 | 8:00AM - 11:15AM
Mitochondrial Bioenergetics and the Induction of Apoptosis
Room: Ballroom 2-3

Speaker 2 of 6
Rosario Rizzuto, University of Padua, Italy
Mitochondrial/ER Ca++ Communication during Apoptosis

Tuesday, April 04 | 8:00AM - 11:15AM
Mitochondrial Bioenergetics and the Induction of Apoptosis
Room: Ballroom 2-3

Speaker 3 of 6
Pierluigi Nicotera, University of Leicester, UK
Transduction of Cellular and Mitochondrial Calcium Signals to the Neuronal Death Machineries

Tuesday, April 04 | 8:00AM - 11:15AM
Mitochondrial Bioenergetics and the Induction of Apoptosis
Room: Ballroom 2-3

Speaker 4 of 6
Paolo Bernardi, University of Padova Medical School, Italy
Properties of the Permeability Transition in Mitochondria from VDAC1-/- and Ppif-/- mice

Tuesday, April 04 | 8:00AM - 11:15AM
Mitochondrial Bioenergetics and the Induction of Apoptosis
Room: Ballroom 2-3

Speaker 5 of 6
Roman A. Eliseev, University of Rochester Medical Center, USA
Short Talk: The Role of Cyclophilin D in the Resistance of Brain Mitochondria to the Ca2+ Induced MPT

Tuesday, April 04 | 8:00AM - 11:15AM
Mitochondrial Bioenergetics and the Induction of Apoptosis
Room: Ballroom 2-3

Speaker 6 of 6
J. Kevin Foskett, University of Pennsylvania, USA
Short Talk: The ImsP3 Receptor Ca2+ release Channel and the Endoplasmic Reticulum Gateway to Apoptosis

Tuesday, April 04 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine & Lobby


Tuesday, April 04 | 11:15AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Maybird


Tuesday, April 04 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Maybird


Tuesday, April 04 | 4:30PM - 5:00PM
Coffee Available
Room: Superior/Superior Lobby/Maybird


Tuesday, April 04 | 5:00PM - 7:00PM
The Role of Macroautophagy in Cell Death and Bioenergetics
Room: Ballroom 2-3

Speaker 1 of 4
Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
Autophagy and Aerobic Gycolysis Represent the Extremes of Intermediate Metabolism in Cells Dependent on Receptor-Directed Nutrient Uptake

Tuesday, April 04 | 5:00PM - 7:00PM
The Role of Macroautophagy in Cell Death and Bioenergetics
Room: Ballroom 2-3

Speaker 2 of 4
Devrim Gozuacik, Sabanci University, Turkey
The DAP-Kinase Family of Proteins: Analysis of their Structure and Function at the Apoptosis/Autophagic Cell Death Junction

Tuesday, April 04 | 5:00PM - 7:00PM
The Role of Macroautophagy in Cell Death and Bioenergetics
Room: Ballroom 2-3

Speaker 3 of 4
Stéphen Manon, Centre National de la Recherche Scientifique, France
Short Talk: Mitochondria-Selective Autophagy (Mitophagy) in Yeast

Tuesday, April 04 | 5:00PM - 7:00PM
The Role of Macroautophagy in Cell Death and Bioenergetics
Room: Ballroom 2-3

Speaker 4 of 4
Li Yu, Tsinghua University, China
Short Talk: Autophagic Programmed Cell Death by Selective Catalase Degradation

Tuesday, April 04 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Maybird


Tuesday, April 04 | 7:30PM - 10:00PM
Poster Session 2
Room: Superior/Superior Lobby/Maybird


Wednesday, April 05 | 7:00AM - 8:00AM
Breakfast
Room: Wasatch / Superior Lobby


Wednesday, April 05 | 8:00AM - 11:00AM
Metabolic Regulators of Mitochondrial Cell Death
Room: Ballroom 2-3

Speaker 1 of 5
Nika N. Danial, Dana-Farber Cancer Institute, USA
Dual Role of the Pro-Apoptotic BCL-2 Protein BAD in Insulin Secretion and beta Cell Survival

Wednesday, April 05 | 8:00AM - 11:00AM
Metabolic Regulators of Mitochondrial Cell Death
Room: Ballroom 2-3

Speaker 2 of 5
Gregg L. Semenza, Johns Hopkins University School of Medicine, USA
Regulation of Lipid and Glucose Metabolism and Cell Survival by Hypoxia-Inducible Factor 1

Wednesday, April 05 | 8:00AM - 11:00AM
Metabolic Regulators of Mitochondrial Cell Death
Room: Ballroom 2-3

Speaker 3 of 5
* Donald D. Newmeyer, La Jolla Institute for Allergy and Immunology, USA
Death and the Mitochondrion

Wednesday, April 05 | 8:00AM - 11:00AM
Metabolic Regulators of Mitochondrial Cell Death
Room: Ballroom 2-3

Speaker 4 of 5
Brian M. Polster, University of Maryland School of Medicine, USA
Mechanisms and Consequences of Mitochondrial Permeabilization

Wednesday, April 05 | 8:00AM - 11:00AM
Metabolic Regulators of Mitochondrial Cell Death
Room: Ballroom 2-3

Speaker 5 of 5
Kah Fei Wan, Institute of Molecular and Cell Biology, Singapore
Short Talk: Chelerythrine Confers Cytotoxicity on Mammalian Cells through a Bax-, Bak-Independent Apoptotic Pathway

Wednesday, April 05 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine & Lobby


Wednesday, April 05 | 11:00AM - 1:00PM
Poster Setup
Room: Superior/Superior Lobby/Maybird


Wednesday, April 05 | 1:00PM - 10:00PM
Poster Viewing
Room: Superior/Superior Lobby/Maybird


Wednesday, April 05 | 2:30PM - 4:30PM
Workshop: Mechanisms of Mitochondrial Outer Membrane Permeab
ilization
Room: Ballroom 2-3

Speaker 1 of 11
* Donald D. Newmeyer, La Jolla Institute for Allergy and Immunology, USA

Wednesday, April 05 | 2:30PM - 4:30PM
Workshop: Mechanisms of Mitochondrial Outer Membrane Permeab
ilization
Room: Ballroom 2-3

Speaker 2 of 11
Salah Abu-Hamad, Ben-Gurion University of the Negev, Israel
Short Talk: The Expression Level of the Voltage-Dependent Anion Channel 1 Controls Life and Death of the Cell

Wednesday, April 05 | 2:30PM - 4:30PM
Workshop: Mechanisms of Mitochondrial Outer Membrane Permeab
ilization
Room: Ballroom 2-3

Speaker 3 of 11
Emilie Alirol, Venetian Institute of Molecular Medecine, Italy
Role of hFis1 in Mitochondrial Fission and Apoptosis


Wednesday, April 05 | 2:30PM - 4:30PM
Workshop: Mechanisms of Mitochondrial Outer Membrane Permeab
ilization
Room: Ballroom 2-3

Speaker 4 of 11
Jeffrey S. Armstrong, National University of Singapore, Singapore
Bax and the Mitochondrial Permeability Transition Cooperate in the Release of Cytochrome C during Thapsigargin Induced Apoptosis

Wednesday, April 05 | 2:30PM - 4:30PM
Workshop: Mechanisms of Mitochondrial Outer Membrane Permeab
ilization
Room: Ballroom 2-3

Speaker 5 of 11
Hubert Frédéric Arokium, France
Molecular Mechanisms Underlying Bax/Mitochondria Interactions during Apoptosis: A Study in Yeast

Wednesday, April 05 | 2:30PM - 4:30PM
Workshop: Mechanisms of Mitochondrial Outer Membrane Permeab
ilization
Room: Ballroom 2-3

Speaker 6 of 11
Laurent Dejean, California State University Fresno, USA
The Mitochondrial Apoptosis-Induced Channel: From a Functional to a Molecular Definition

Wednesday, April 05 | 2:30PM - 4:30PM
Workshop: Mechanisms of Mitochondrial Outer Membrane Permeab
ilization
Room: Ballroom 2-3

Speaker 7 of 11
Francois Gonzalvez, Genentech, USA
Involvement of Cardiolipin in Apoptosis

Wednesday, April 05 | 2:30PM - 4:30PM
Workshop: Mechanisms of Mitochondrial Outer Membrane Permeab
ilization
Room: Ballroom 2-3

Speaker 8 of 11
Sergei A. Novgorodov, Medical University of South Carolina, USA
Long-Chain Ceramides Suppress Mitochondrial Permeability Transition at Physiologically Relevant Concentrations

Wednesday, April 05 | 2:30PM - 4:30PM
Workshop: Mechanisms of Mitochondrial Outer Membrane Permeab
ilization
Room: Ballroom 2-3

Speaker 9 of 11
Patrice X. Petit, Centre de Recherche des Saint-Pères, France
Short Talk: tBid Impaired Mitochondrial Bioenergetic via Cardiolipin Spatial Rearrangement and Favor Subsequent Bax Activity

Wednesday, April 05 | 2:30PM - 4:30PM
Workshop: Mechanisms of Mitochondrial Outer Membrane Permeab
ilization
Room: Ballroom 2-3

Speaker 10 of 11
Tatiana K. Rostovtseva, NICHD, National Institutes of Health, USA
Lipid Composition Regulates VDAC Channel Voltage Gating

Wednesday, April 05 | 2:30PM - 4:30PM
Workshop: Mechanisms of Mitochondrial Outer Membrane Permeab
ilization
Room: Ballroom 2-3

Speaker 11 of 11
Leah J. Siskind, Medical University of South Carolina, USA
Ceramide Channels Regulate the Permeability of the Mitochondrial Outer Membrane to Proapoptotic Proteins

Wednesday, April 05 | 4:30PM - 5:00PM
Coffee Available
Room: Superior/Superior Lobby/Maybird


Wednesday, April 05 | 5:00PM - 7:00PM
Bioenergetics and Neuronal Cell Death
Room: Ballroom 2-3

Speaker 1 of 4
Natalia B. Pivovarova, NINDS, National Institutes of Health, USA
Not All Mitochondria are Created Equal: Calcium Accumulation and Excitotoxic Cell Death

Wednesday, April 05 | 5:00PM - 7:00PM
Bioenergetics and Neuronal Cell Death
Room: Ballroom 2-3

Speaker 2 of 4
David G. Nicholls, Sweden
Quantifying Mitochondrial Bioenergetics in Neurons During Excitotoxic and Apoptotic Cell Death

Wednesday, April 05 | 5:00PM - 7:00PM
Bioenergetics and Neuronal Cell Death
Room: Ballroom 2-3

Speaker 3 of 4
Robert M. Friedlander, Brigham and Women's Hospital, USA
Modulation of Mitochondrial Cell Death Pathways in Acute and Chronic Neurologic Diseases

Wednesday, April 05 | 5:00PM - 7:00PM
Bioenergetics and Neuronal Cell Death
Room: Ballroom 2-3

Speaker 4 of 4
Gregory J. Brewer, Southern Illinois University School of Medicine, USA
Short Talk: Age-Related Declines in Mitochondrial Membrane Potential, Respiratory Complexes, NAD(P)H and Glutathione Cause Catastrophic Redox Decline during Glutamate Treatment of Hippocampal Neurons

Wednesday, April 05 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Maybird


Wednesday, April 05 | 7:30PM - 10:00PM
Poster Session 3
Room: Superior/Superior Lobby/Maybird


Thursday, April 06 | 7:00AM - 8:00AM
Breakfast
Room: Wasatch / Superior Lobby


Thursday, April 06 | 8:00AM - 11:15AM
Oxidative Stress Regulation and Cell Death
Room: Ballroom 2-3

Speaker 1 of 6
Jochen H.M. Prehn, RCSI Research Institute, Ireland
Oxidative Stress and Mitochondrial Bioenergetics During Apoptosis: Lessons from Real Time Single Cell Analyses

Thursday, April 06 | 8:00AM - 11:15AM
Oxidative Stress Regulation and Cell Death
Room: Ballroom 2-3

Speaker 2 of 6
* Martin D. Brand, Medical Research Council, UK
Topology, Sites and Regulation of Mitochondrial Superoxide Production

Thursday, April 06 | 8:00AM - 11:15AM
Oxidative Stress Regulation and Cell Death
Room: Ballroom 2-3

Speaker 3 of 6
Navdeep S. Chandel, Northwestern University, USA
Mitochondria Regulates Apoptosis and Gene Expression during Hypoxia

Thursday, April 06 | 8:00AM - 11:15AM
Oxidative Stress Regulation and Cell Death
Room: Ballroom 2-3

Speaker 4 of 6
Paul S. Brookes, University of Rochester Medical Center, USA
Mitochondria: An End Point for NO Signaling in Ischemic Preconditioning

Thursday, April 06 | 8:00AM - 11:15AM
Oxidative Stress Regulation and Cell Death
Room: Ballroom 2-3

Speaker 5 of 6
Gary L. Wright, Quillen College of Medicine, USA
Short Talk: The Prolyl Hydroxylase Oxygen-Sensor Confers Cytoprotection through Multiple Mechanisms that Include the Maintenance of Mitochondrial Membrane Potential during Metabolic Inhibition

Thursday, April 06 | 8:00AM - 11:15AM
Oxidative Stress Regulation and Cell Death
Room: Ballroom 2-3

Speaker 6 of 6
Nuno Raimundo, University Medical Center Goettingen, Germany
Short Talk: Respiratory Chain Malfunction and TCA Cycle Defects Activate Hypoxia Response

Thursday, April 06 | 9:20AM - 9:40AM
Coffee Break
Room: Ballroom Mezzanine & Lobby


Thursday, April 06 | 4:30PM - 5:00PM
Coffee Available
Room: Superior/Superior Lobby/Maybird


Thursday, April 06 | 5:00PM - 7:00PM
Therapeutic Prevention of Mitochondrial Cell Death
Room: Ballroom 2-3

Speaker 1 of 4
* Valina L. Dawson, Johns Hopkins University School of Medicine, USA
Poly(ADP-ribose) is a new messenger signaling life or death.

Thursday, April 06 | 5:00PM - 7:00PM
Therapeutic Prevention of Mitochondrial Cell Death
Room: Ballroom 2-3

Speaker 2 of 4
Mike P. Murphy, Medical Research Council, UK
Mitochondria-Targeted Antioxidants and Redox Probes

Thursday, April 06 | 5:00PM - 7:00PM
Therapeutic Prevention of Mitochondrial Cell Death
Room: Ballroom 2-3

Speaker 3 of 4
Gustav Mattiasson, Wallenberg Neuroscience Center, Sweden
UCP2-Mediated Neuroprotection Following Ischemia and Traumatic Brain Injury

Thursday, April 06 | 5:00PM - 7:00PM
Therapeutic Prevention of Mitochondrial Cell Death
Room: Ballroom 2-3

Speaker 4 of 4
Bruno Miroux, Centre National de la Recherche Scientifique, France
Short Talk: A Protective Role for Uncoupling Protein 2 (UCP2) in Experimental Autoimmune Encephalitis

Thursday, April 06 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Superior/Superior Lobby/Maybird


Thursday, April 06 | 8:00PM - 11:00PM
Entertainment
Room: Ballroom 2-3


Thursday, April 06 | 8:00PM - 11:00PM
Cash Bar
Room: Ballroom 2-3


Friday, April 07 | 10:21AM - 10:21AM
Departure


*Session Chair
†Invited, not yet responded.