Web Desc
Determinants of Host Resistance, Susceptibility or Immunopathology to Pathogens: Integrating Knowledge from Experimental Models to Human Disease
joint with Pathogen-Host Standoff: Persistent and Latent Infection
Organizer(s): Anne O'Garra, Anne E. Goldfeld, Alan Sher and Bruce D. Walker
Date: January 06 - 11, 2006
Location: Keystone Resort, Keystone, CO, USA
Supported by the Burroughs Wellcome Fund and The Director's Fund
Summary of Meeting:
The type of immune response that is elicited upon infection of a host with a pathogen is critical in determining whether the pathogen is eradicated or whether chronic infection ensues. Successful protective effector responses to intracellular pathogens such as parasites, bacteria and viruses are initiated by cells of the innate immune response which produce effector cytokines such as TNF, IL-12 or IFN-alpha. These, in turn, stimulate antigen-specific Th1 cells producing IFN-alpha and CD8+ T cytotoxic T cells (CTL). Humoral immune responses also offer protection against pathogens, however rapid mutations in the organisms and/or the lack of immunizing regimens which lead to long-term protection impede successful vaccination. Host mutations in cytokine signaling pathways and signaling pathways downstream of pattern recognition receptors on host immune cells result in profound susceptibility to a number of pathogens. Furthermore, many organisms -- such as Leishmania, Schistosoma or Mycobacteria -- inhibit protective immune responses via the induction of suppressive cytokines, whereas influenza has developed molecular mechanisms to interfere directly with signaling pathways important for the induction of the host antiviral response. Overall, major reasons why we have failed to-date in eliminating human pathogens are 1) successful strategies of immunoevasion developed by pathogens to dampen an immune response and, conversely, 2) pathogen-induced immunopathologies further complicate infections. Furthermore, the emergence and re-emergence of many infectious pathogens throughout human history, the difficulty in producing effective vaccines to protect against numerous pathogens, and the inability to intervene immunologically to abrogate many chronic infectious diseases such as HIV, malaria, TB, and schistosomiasis highlight the need for a deeper understanding of the immune response to infectious challenge. Cross-fertilization of knowledge gained from animal models of infectious disease with our understanding of human immune responses to a broad range of pathogens is critical to advance the treatment and prevention of devastating pathogens.
Scholarship Deadline: September 13 2005
Discounted Abstract Deadline: September 13 2005
Abstract Deadline: October 3 2005
Discounted Registration Deadline: November 4 2005
We gratefully acknowledge additional support for this conference from:
Burroughs Wellcome Fund
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

Merck Vaccine Division
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Allergy and Infectious Diseases (NIAID)
Grant No. 1 R13 AI066871-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Friday, January 06 | 8:00AM - 11:00AM
Cell-Intrinsic Responses to Pathogens
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 1 of 5
John Hiscott, Vaccine & Gene Therapy Institute of Florida, USA
Regulation of Antiviral Defense and Apoptosis by the IRF Transcription Factors


Friday, January 06 | 8:00AM - 11:00AM
Cell-Intrinsic Responses to Pathogens
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 2 of 5
J. Marie Hardwick, Johns Hopkins University Schools of Public Health and Medicine, USA
Programmed Cell Death in Viral Pathogenesis


Friday, January 06 | 8:00AM - 11:00AM
Cell-Intrinsic Responses to Pathogens
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 3 of 5
* Edward S. Mocarski, Emory University, USA
Cell Intrinsic Responses in Cytomegalovirus Replication and Pathogenesis


Friday, January 06 | 8:00AM - 11:00AM
Cell-Intrinsic Responses to Pathogens
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 4 of 5
Kathryn E. Foulds, NIAID, National Institutes of Health, USA
Short Talk: IL-10 is Required for Optimal CD8 T Cell Memory following Listeria monocytogenes Infection


Friday, January 06 | 8:00AM - 11:00AM
Cell-Intrinsic Responses to Pathogens
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 5 of 5
Dorian B. McGavern, NINDS, National Institutes of Health, USA
Short Talk: Adoptive Immunotherapy Induces Dendritic Cell Recruitment and Antigen Presentation in the CNS during the Clearance of a Persistent Viral Infection


Friday, January 06 | 3:00PM - 7:00PM
Registration
Room: Shavano Peak Foyer


Friday, January 06 | 5:00PM - 7:00PM
Pathogen Escape from Control
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 1 of 4
Dan R. Littman, HHMI/New York University School of Medicine, USA
Roles of Dendritic Cells in Intestinal Immunity and HIV Pathogenesis


Friday, January 06 | 5:00PM - 7:00PM
Pathogen Escape from Control
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 2 of 4
Christopher L. Karp, Bill & Melinda Gates Foundation, USA
Regulation of TLR Signaling and the Host Interface with Pathogens and Danger


Friday, January 06 | 5:00PM - 7:00PM
Pathogen Escape from Control
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 3 of 4
* Alan G. Barbour, University of California, Irvine, USA
Antigenic Variation by Borrelia Species in Natural Hosts


Friday, January 06 | 5:00PM - 7:00PM
Pathogen Escape from Control
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 4 of 4
Chris A. Benedict, La Jolla Institute for Allergy and Immunology, USA
Short Talk: Herpesvirus Targeting of the HVEM-BTLA Cosignaling System


Friday, January 06 | 7:00PM - 8:00PM
Refreshments
Room: Shavano Peak Foyer


Friday, January 06 | 8:00PM - 9:00PM
Keynote Address
Room: Red Cloud Peak

Speaker 1 of 1
Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland
The Immune Battle Against Infectious Organisms: From Mouse Models to Human Disease

Saturday, January 07 | 7:00AM - 8:00AM
Breakfast
Room: Torreys 1-4


Saturday, January 07 | 8:00AM - 11:15AM
Immune Mechanisms for Protection versus Progression: From Mo
use Models to Human Disease

Room: Red Cloud

Speaker 1 of 6
* Anne O'Garra, Francis Crick Institute, UK
Development of Suppressive or Protective Immune Responses to Pathogens: Implications for Control of TB

Saturday, January 07 | 8:00AM - 11:15AM
Immune Mechanisms for Protection versus Progression: From Mo
use Models to Human Disease

Room: Red Cloud

Speaker 2 of 6
Alan Sher, NIAID, National Institutes of Health, USA
TLR Co-Operation in Host Defense against Intracellular Pathogens

Saturday, January 07 | 8:00AM - 11:15AM
Immune Mechanisms for Protection versus Progression: From Mo
use Models to Human Disease

Room: Red Cloud

Speaker 3 of 6
Anne E. Goldfeld, Children's Hospital Boston, Harvard Medical School, USA
TB and HIV Pathogenesis: From the Field to the Bedside

Saturday, January 07 | 8:00AM - 11:15AM
Immune Mechanisms for Protection versus Progression: From Mo
use Models to Human Disease

Room: Red Cloud

Speaker 4 of 6
Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard, USA
Immune Control and Immune Failure in HIV infection

Saturday, January 07 | 8:00AM - 11:15AM
Immune Mechanisms for Protection versus Progression: From Mo
use Models to Human Disease

Room: Red Cloud

Speaker 5 of 6
Andrea M. Cooper, University of Leicester, UK
Short Talk: IL-23 is Required for Vaccine-Induced Protection Against Aerosol-Delivered Mycobacterium Tuberculosis infection

Saturday, January 07 | 8:00AM - 11:15AM
Immune Mechanisms for Protection versus Progression: From Mo
use Models to Human Disease

Room: Red Cloud

Speaker 6 of 6
Jay K. Kolls, Tulane School of Medicine, USA
Short Talk: IL-23/IL-17: Roles in Host Defense Against Acute Extracellular Gram Negative Bacteria and Immnuopathology in Chronic Bacterial Infection

Saturday, January 07 | 8:00AM - 11:00AM
Patterns of Pathogen Growth and Behavior
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 1 of 5
Diane E. Griffin, Johns Hopkins Bloomberg School of Public Health, USA
Measles: Virus Clearance and Protective Immunity


Saturday, January 07 | 8:00AM - 11:00AM
Patterns of Pathogen Growth and Behavior
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 2 of 5
Herbert (Skip) W. Virgin, Vir Biotechnology, USA
The Host:Herpesvirus Standoff: Good News from the Front of an Ancient Battle


Saturday, January 07 | 8:00AM - 11:00AM
Patterns of Pathogen Growth and Behavior
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 3 of 5
* JoAnne L. Flynn, University of Pittsburgh School of Medicine, USA
Dynamic Immune Responses in Tuberculosis


Saturday, January 07 | 8:00AM - 11:00AM
Patterns of Pathogen Growth and Behavior
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 4 of 5
Jennifer Philips, Washington University School of Medicine, USA
Short Talk: Genome-Wide RNAi Screens in Drosophila Identify Host Factors Involved in Mycobacterial Infection


Saturday, January 07 | 8:00AM - 11:00AM
Patterns of Pathogen Growth and Behavior
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 5 of 5
Linda F. van Dyk, University of Colorado Health Sciences Center, USA
Short Talk: Interactions of a Viral Cyclin and a Host Inhibitor in Control of gammaherpesvirus Infection


Saturday, January 07 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Saturday, January 07 | 11:00AM - 1:00PM
Poster Setup
Room: Torreys 1-4


Saturday, January 07 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys 1-4


Saturday, January 07 | 2:30PM - 4:30PM
Workshop 1: Host Susceptibility and Resistance Mechanisms in
Mouse and Man
Room: Red Cloud Peak

Speaker 1 of 9
* Charles R.M. Bangham, Imperial College Department of Medicine, UK

Saturday, January 07 | 2:30PM - 4:30PM
Workshop 1: Host Susceptibility and Resistance Mechanisms in
Mouse and Man
Room: Red Cloud Peak

Speaker 2 of 9
Victoria Olivia Kasprowicz, Harvard Medical School, USA
Small Virus – Big Response: Divergent CD4+ and CD8+ T Cell Immune Responses After Acute Parvovirus B19 Infection

Saturday, January 07 | 2:30PM - 4:30PM
Workshop 1: Host Susceptibility and Resistance Mechanisms in
Mouse and Man
Room: Red Cloud Peak

Speaker 3 of 9
* George Kassiotis, Francis Crick Institute, UK
Memory T Helper Cell Heterogeneity

Saturday, January 07 | 2:30PM - 4:30PM
Workshop 1: Host Susceptibility and Resistance Mechanisms in
Mouse and Man
Room: Red Cloud Peak

Speaker 4 of 9
Anthony A. Ryan, Centenary Institute of Cancer Medicine & Cell Biology, Australia
Targeting Antigen Presenting Cells as a Strategy to Improve Protective Immunity Against Tuberculosis

Saturday, January 07 | 2:30PM - 4:30PM
Workshop 1: Host Susceptibility and Resistance Mechanisms in
Mouse and Man
Room: Red Cloud Peak

Speaker 5 of 9
Anuratha Sakthianandeswaren, Walter and Eliza Hall Institute of Medical Research, Australia
The Wound Repair Response Controls Outcome to Murine Cutaneous Leishmaniasis

Saturday, January 07 | 2:30PM - 4:30PM
Workshop 1: Host Susceptibility and Resistance Mechanisms in
Mouse and Man
Room: Red Cloud Peak

Speaker 6 of 9
Thomas J. Scriba, University of Cape Town, South Africa
Optimized HLA Class II Tetramer Staining Allows Ultra-Sensitive Detection and Phenotyping of Antigen-Specific CD4+ T Cells

Saturday, January 07 | 2:30PM - 4:30PM
Workshop 1: Host Susceptibility and Resistance Mechanisms in
Mouse and Man
Room: Red Cloud Peak

Speaker 7 of 9
Felix Yarovinsky, University of Rochester Medical Center, USA
Toll-Like Receptor 11 Recognition Renders Toxoplasma Profilin into an Immunodominant Antigen in the CD4+T Cell Response to the Parasite

Saturday, January 07 | 2:30PM - 4:30PM
Workshop 1: Host Susceptibility and Resistance Mechanisms in
Mouse and Man
Room: Red Cloud Peak

Speaker 8 of 9
Karina Yusim, Los Alamos National Laboratory, USA
Rational HIV and Hepatitis C Vaccine Design to Optimize T Cell Responses

Saturday, January 07 | 2:30PM - 4:30PM
Workshop 1: Host Susceptibility and Resistance Mechanisms in
Mouse and Man
Room: Red Cloud Peak

Speaker 9 of 9
Shane Crotty, La Jolla Institute for Immunology, USA
SAP Deficiency Triggers CD8-Mediated Immunopathology and Hypogammaglobulinemia in a Non-Herpesvirus Chronic Infection

Saturday, January 07 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Saturday, January 07 | 5:00PM - 7:00PM
Determinants of Chronicity in Viral Infection
Room: Red Cloud Peak

Speaker 1 of 4
Mark B. Feinberg, IAVI International AIDS Vaccine Initiative, USA
Host-Virus Relationships in Nonpathogenic SIV Infections

Saturday, January 07 | 5:00PM - 7:00PM
Determinants of Chronicity in Viral Infection
Room: Red Cloud Peak

Speaker 2 of 4
* David I. Watkins, University of Miami, USA
Defining a Protective Immune Response: In vivo Depletion of CD8
Lymphocytes in Elite SIV Controllers


Saturday, January 07 | 5:00PM - 7:00PM
Determinants of Chronicity in Viral Infection
Room: Red Cloud Peak

Speaker 3 of 4
Philip J. Goulder, University of Oxford, UK
Immune Selection Pressure, Viral Evolution and Host Evolution in HIV Infection

Saturday, January 07 | 5:00PM - 7:00PM
Determinants of Chronicity in Viral Infection
Room: Red Cloud Peak

Speaker 4 of 4
Charles R.M. Bangham, Imperial College Department of Medicine, UK
Short Talk: Immune Containment and Cell to Cell Spread of the Human Leukemia Virus HTLV-1

Saturday, January 07 | 5:00PM - 7:00PM
Regulation of Innate and Adaptive Immunity
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 1 of 4
E. John Wherry, University of Pennsylvania, USA
Maintenance properties of virus specific CD8 T cells during chronic infection


Saturday, January 07 | 5:00PM - 7:00PM
Regulation of Innate and Adaptive Immunity
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 2 of 4
* Yasmine Belkaid, NIAID, National Institutes of Health, USA
Regulatory T Cells and Parasite Persistence


Saturday, January 07 | 5:00PM - 7:00PM
Regulation of Innate and Adaptive Immunity
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 3 of 4
Christine A. Biron, Brown University, USA
Integrating and Shaping Early Events in Immunity to Viral Infections


Saturday, January 07 | 5:00PM - 7:00PM
Regulation of Innate and Adaptive Immunity
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 4 of 4
Jason A. Skinner, University of Pennsylvania School of Medicine, USA
Short Talk: Bordetella bronchiseptica Modulates Dendritic Cell Function and Host Immunity to Establish Persistent Infection


Saturday, January 07 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys 1-4


Saturday, January 07 | 7:30PM - 10:00PM
Poster Session 1
Room: Torreys 1-4


Sunday, January 08 | 7:00AM - 8:00AM
Breakfast
Room: Torreys 1-4


Sunday, January 08 | 8:00AM - 11:15AM
Pattern Recognition in Persistent and Latent Infection (Join
t)

Room: Red Cloud

Speaker 1 of 6
Caetano Reis e Sousa, Francis Crick Institute, UK
Pattern Recognition Pathways in Dendritic Cells

Sunday, January 08 | 8:00AM - 11:15AM
Pattern Recognition in Persistent and Latent Infection (Join
t)

Room: Red Cloud

Speaker 2 of 6
Eric G. Pamer, University of Chicago, USA
Immune Response to Aspergillus fumigatus Infection

Sunday, January 08 | 8:00AM - 11:15AM
Pattern Recognition in Persistent and Latent Infection (Join
t)

Room: Red Cloud

Speaker 3 of 6
* Michael B. Brenner, Harvard Medical School, USA
Lipid Antigen Presentation by CD1 Results in Rapid T Cell Activation As Well As Adaptive Immunity

Sunday, January 08 | 8:00AM - 11:15AM
Pattern Recognition in Persistent and Latent Infection (Join
t)

Room: Red Cloud

Speaker 4 of 6
Edward J. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Helminth Control of Dendritic Cell Function

Sunday, January 08 | 8:00AM - 11:15AM
Pattern Recognition in Persistent and Latent Infection (Join
t)

Room: Red Cloud

Speaker 5 of 6
Weiming Yuan, University of Southern California, USA
Short Talk: Immune Evasion of HSV-1 by Down-Regulation of CD1d Expression

Sunday, January 08 | 8:00AM - 11:15AM
Pattern Recognition in Persistent and Latent Infection (Join
t)

Room: Red Cloud

Speaker 6 of 6
Helle Bielefeldt-Ohmann, Colorado State University, USA
Short Talk: Helicobacter Induced Colon Cancer in Smad3 Deficient Mice: A Synergistic Effect of Dysregulated Epithelial Proliferation and Deficient Regulation of Inflammation?

Sunday, January 08 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Sunday, January 08 | 11:00AM - 1:00PM
Poster Setup
Room: Torreys 1-4


Sunday, January 08 | 1:00PM - 10:00PM
Poster Viewing
Room: Torreys 1-4


Sunday, January 08 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Sunday, January 08 | 5:00PM - 7:00PM
Genetics of Immune Responses to Pathogens
Room: Red Cloud Peak

Speaker 1 of 3
* Jean-Laurent Casanova, Rockefeller University, USA
A Genetic Dissection of Cytokine-Mediated Immunity to Infection in Humans

Sunday, January 08 | 5:00PM - 7:00PM
Genetics of Immune Responses to Pathogens
Room: Red Cloud Peak

Speaker 2 of 3
Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Role of Host Innate and Adaptive Immune Response Genes in Resistance to Pathogens in Mouse Models

Sunday, January 08 | 5:00PM - 7:00PM
Genetics of Immune Responses to Pathogens
Room: Red Cloud Peak

Speaker 3 of 3
Thomas R. Hawn, University of Washington, USA
Short Talk: Polymorphisms in TLR-Pathway Genes are Associated with Signaling Deficiencies and Increased Susceptibility to Tuberculosis

Sunday, January 08 | 5:00PM - 7:00PM
Challenges of the Intracellular Lifestyle
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 1 of 4
* Daniel A. Portnoy, University of California, Berkeley, USA
How Listeria monocytogenes Avoids Killing its Host Cell


Sunday, January 08 | 5:00PM - 7:00PM
Challenges of the Intracellular Lifestyle
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 2 of 4
David G. Russell, Cornell University, USA
Mycobacterium Tuberculosis and the Innate Immune Tune


Sunday, January 08 | 5:00PM - 7:00PM
Challenges of the Intracellular Lifestyle
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 3 of 4
Anita Sil, University of California, San Francisco, USA
Histoplasma capsulatum Development in Pathogenesis


Sunday, January 08 | 5:00PM - 7:00PM
Challenges of the Intracellular Lifestyle
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 4 of 4
Yun Ling, Brown University, USA
Short Talk: Rapid Elimination of Toxoplasma gondii in Primed Macrophages: The Role of IGTP and Lysosomal Fusion


Sunday, January 08 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys 1-4


Sunday, January 08 | 7:30PM - 10:00PM
Poster Session 2
Room: Torreys 1-4


Monday, January 09 | 7:00AM - 8:00AM
Breakfast
Room: Torreys 1-4


Monday, January 09 | 8:00AM - 11:15AM
Pathogen Manipulation of the Host Immune Response; For Bette
r or For Worse

Room: Red Cloud Peak

Speaker 1 of 6
Carl F. Nathan, Weill Cornell Medical College, USA
Host-Pathogen Relationship as Competitive Genomic Immunological Challenges of TB

Monday, January 09 | 8:00AM - 11:15AM
Pathogen Manipulation of the Host Immune Response; For Bette
r or For Worse

Room: Red Cloud Peak

Speaker 2 of 6
Philippe J. Sansonetti, Institut Pasteur, France
Rupture, Invasion and Inflammatory Destruction of the Intestinal Epithelium by Shigella: The Yin and the Yang of Innate Immunity

Monday, January 09 | 8:00AM - 11:15AM
Pathogen Manipulation of the Host Immune Response; For Bette
r or For Worse

Room: Red Cloud Peak

Speaker 3 of 6
Françoise Barré-Sinoussi, Institut Pasteur, France
Lessons from Early Responses to Nonpathogenic SIV Infection in African Green Monkeys

Monday, January 09 | 8:00AM - 11:15AM
Pathogen Manipulation of the Host Immune Response; For Bette
r or For Worse

Room: Red Cloud Peak

Speaker 4 of 6
* Carl F. Ware, Sanford-Burnham Medical Research Institute, USA
Virus Modulation of the TNF Superfamily

Monday, January 09 | 8:00AM - 11:15AM
Pathogen Manipulation of the Host Immune Response; For Bette
r or For Worse

Room: Red Cloud Peak

Speaker 5 of 6
Javier A. Carrero, Washington University, USA
Short Talk: Role of Listeriolysin O in the in vivo Virulence of Listeria Monocytogenes

Monday, January 09 | 8:00AM - 11:15AM
Pathogen Manipulation of the Host Immune Response; For Bette
r or For Worse

Room: Red Cloud Peak

Speaker 6 of 6
John E. Connolly, Parker Institute for Cancer Immunotherapy, USA
Short Talk: Respiratory Syncytial Virus Subverts the Immune Response through the Induction of Tolerogenic Myeloid Dendritic Cells

Monday, January 09 | 8:00AM - 11:00AM
Persistence in the Face of Adaptive
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 1 of 4
Britta C. Urban, University of Oxford, UK
Modulation of Dendritic Cell Funtion by Plasmodium Falciparum-Infected Erythrocytes: The Malaria-T Cell Standoff


Monday, January 09 | 8:00AM - 11:00AM
Persistence in the Face of Adaptive
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 2 of 4
Kevin B. Urdahl, Seattle Children's Research Institute, USA
Location and Function of Foxp3-Expressing T Regulatory Cells during Tuberculosis


Monday, January 09 | 8:00AM - 11:00AM
Persistence in the Face of Adaptive
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 3 of 4
* Michael Starnbach, Harvard Medical School, USA
Cellular Immune Control of Persistent Bacterial Infection


Monday, January 09 | 8:00AM - 11:00AM
Persistence in the Face of Adaptive
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 4 of 4
David M. Lewinsohn, Oregon Health & Science University, USA
Short Talk: HLA-E Restricted Human CD8+ T Cells Recognize Post-Translationally Modified HspX from Mycobacterium Tuberculosis


Monday, January 09 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Monday, January 09 | 2:30PM - 4:30PM
Workshop 2: Shared Mechanisms of Pathogenesis in Mice and Me
n
Room: Red Cloud Peak

Speaker 1 of 9
* Andrea M. Cooper, University of Leicester, UK

Monday, January 09 | 2:30PM - 4:30PM
Workshop 2: Shared Mechanisms of Pathogenesis in Mice and Me
n
Room: Red Cloud Peak

Speaker 2 of 9
* Paul Klenerman, University of Oxford, UK

Monday, January 09 | 2:30PM - 4:30PM
Workshop 2: Shared Mechanisms of Pathogenesis in Mice and Me
n
Room: Red Cloud Peak

Speaker 3 of 9
Sara R. Klucking, Emory University, USA
Inefficient Production of IFNa by pDCs is Involved in the Limited Immune Activation and AIDS-Resistance in Naturally SIV-Infected SMs.

Monday, January 09 | 2:30PM - 4:30PM
Workshop 2: Shared Mechanisms of Pathogenesis in Mice and Me
n
Room: Red Cloud Peak

Speaker 4 of 9
Alasdair J. Leslie, Kwazulu Natal Research Institute for HIV and TB, South Africa
The Biological Relevance of Supertypes in HIV-1 Infection

Monday, January 09 | 2:30PM - 4:30PM
Workshop 2: Shared Mechanisms of Pathogenesis in Mice and Me
n
Room: Red Cloud Peak

Speaker 5 of 9
Emily J. Lyons, Wellcome Trust Centre for Human Genetics, UK
Consanguinity and Susceptibility to Human Infectious Diseases

Monday, January 09 | 2:30PM - 4:30PM
Workshop 2: Shared Mechanisms of Pathogenesis in Mice and Me
n
Room: Red Cloud Peak

Speaker 6 of 9
Amarendra Pegu, NIAID, National Institutes of Health, USA
Interactions between Mycobacterium Tuberculosis and the Lymphatic Endothelium

Monday, January 09 | 2:30PM - 4:30PM
Workshop 2: Shared Mechanisms of Pathogenesis in Mice and Me
n
Room: Red Cloud Peak

Speaker 7 of 9
Shahin Ranjbar, Immune Disease Institute, USA
Tat from HIV-1 Subtype E Selectively Inhibits TNF Gene Expression via Interference with Chromatin Remodeling of the TNF Locus

Monday, January 09 | 2:30PM - 4:30PM
Workshop 2: Shared Mechanisms of Pathogenesis in Mice and Me
n
Room: Red Cloud Peak

Speaker 8 of 9
Thuong T. T. Nguyen, Oxford University Clinical Research Unit, Vietnam
A Polymorphism in Human TLR2 is Associated with Increased Susceptibility to Tuberculous Meningitis

Monday, January 09 | 2:30PM - 4:30PM
Workshop 2: Shared Mechanisms of Pathogenesis in Mice and Me
n
Room: Red Cloud Peak

Speaker 9 of 9
Esther Van De Vosse, Leiden University Medical Center, Netherlands
Host Genetics of Salmonella (para-) Typhi Infection

Monday, January 09 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Monday, January 09 | 5:00PM - 7:00PM
Diverse Immune Cells Combat Pathogens
Room: Red Cloud Peak

Speaker 1 of 4
* Stefan H. E. Kaufmann, Max Planck Institute for Infection Biology, Berlin, Germany
Interpretation of the Natural Host-Pathogen Crosstalk Provides Guidelines for Vaccine Design against Tuberculosis

Monday, January 09 | 5:00PM - 7:00PM
Diverse Immune Cells Combat Pathogens
Room: Red Cloud Peak

Speaker 2 of 4
David L. Sacks, NIAID, National Institutes of Health, USA
Immunology of Non-Curing Forms of Leishmaniasis in Mice and Humans

Monday, January 09 | 5:00PM - 7:00PM
Diverse Immune Cells Combat Pathogens
Room: Red Cloud Peak

Speaker 3 of 4
Paul Klenerman, University of Oxford, UK
HCV immunology – Tracking T cells in viral persistence

Monday, January 09 | 5:00PM - 7:00PM
Diverse Immune Cells Combat Pathogens
Room: Red Cloud Peak

Speaker 4 of 4
David G. Brooks, Princess Margaret Cancer Center, Canada
Short Talk: Functional Re-Programming of Antiviral T Cells: Prevention of Clonal Deletion and Restoration of T Cell Activity during Persistent Viral Infection

Monday, January 09 | 5:00PM - 7:00PM
Successful Persistence and Latency Themes
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 1 of 4
Louis J. Picker, Oregon Health & Science University, USA
Immunobiology of Cmv Infection in Rhesus Macaques


Monday, January 09 | 5:00PM - 7:00PM
Successful Persistence and Latency Themes
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 2 of 4
Christopher M. Walker, Nationwide Children's Hospital, USA
Protection Against Hepatitis C Virus Infection


Monday, January 09 | 5:00PM - 7:00PM
Successful Persistence and Latency Themes
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 3 of 4
* David Thorley-Lawson, Tufts University School of Medicine, USA
Persistence of the Epstein-Barr Virus and the Origins of Associated Lymphomas for Real and in Virtual Reality.


Monday, January 09 | 5:00PM - 7:00PM
Successful Persistence and Latency Themes
This session is from Pathogen-Host Standoff
Room: Shavano Peak

Speaker 4 of 4
Rajeev Mani Nepal, Ohio State University, USA
Short Talk: DM, but not Cathepsin L, is Required to Control an Aerosol Infection with Mycobacterium tuberculosis


Monday, January 09 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Torreys 1-4


Monday, January 09 | 8:00PM - 11:00PM
Entertainment
Room: Torreys 1-4


Monday, January 09 | 8:00PM - 11:00PM
Cash Bar
Room: Torreys 1-4


Tuesday, January 10 | 7:00AM - 8:00AM
Breakfast
Room: Torreys 1-4


Tuesday, January 10 | 8:00AM - 11:00AM
Type-1 IFN: Friend or Foe
Room: Red Cloud Peak

Speaker 1 of 5
* Giorgio Trinchieri, NCI, National Institutes of Health, USA
IFN-alpha in the Fight Against Infectious Diseases

Tuesday, January 10 | 8:00AM - 11:00AM
Type-1 IFN: Friend or Foe
Room: Red Cloud Peak

Speaker 2 of 5
Malik Peiris, University of Hong Kong, Hong Kong
SARS, Avian Influenza and Innate Immune Responses

Tuesday, January 10 | 8:00AM - 11:00AM
Type-1 IFN: Friend or Foe
Room: Red Cloud Peak

Speaker 3 of 5
Emil R. Unanue, Washington University School of Medicine, USA
Lymphocyte Apoptosis in Infection: Molecular Basis and Biology

Tuesday, January 10 | 8:00AM - 11:00AM
Type-1 IFN: Friend or Foe
Room: Red Cloud Peak

Speaker 4 of 5
Richard Pine, Public Health Research Institute, USA
Short Talk: Autocrin/Paracrine Responses to IFNalpha/beta Produced by Mtb Infected Macrophages

Tuesday, January 10 | 8:00AM - 11:00AM
Type-1 IFN: Friend or Foe
Room: Red Cloud Peak

Speaker 5 of 5
Steven W. Dow, Colorado State University, USA
Short Talk: Deleterious Role for Type I Interferons in Systemic Yersinia pestis Infections

Tuesday, January 10 | 9:20AM - 9:40AM
Coffee Break
Room: Shavano Peak Foyer


Tuesday, January 10 | 2:30PM - 4:30PM
Workshop 3: Immunoregulation and Immune Evasion in Infectiou
s Diseases
Room: Red Cloud Peak

Speaker 1 of 7
Ian R. Humphreys, Cardiff University, UK
OX40 Limits CMV Persistence in an Organ-Specific Manner that is Dependent on Distinct T Cell Subsets

Tuesday, January 10 | 2:30PM - 4:30PM
Workshop 3: Immunoregulation and Immune Evasion in Infectiou
s Diseases
Room: Red Cloud Peak

Speaker 2 of 7
John J. Osterholzer, Ann Arbor VA Hospital and University of Michigan, USA
CCR2 Mediates the Recruitment of Myeloid and Plasmacytoid Dendritic Cells to the Lungs of Mice Infected with Crypotoccus neoformans: Implications for Th1/Th2 Polarization

Tuesday, January 10 | 2:30PM - 4:30PM
Workshop 3: Immunoregulation and Immune Evasion in Infectiou
s Diseases
Room: Red Cloud Peak

Speaker 3 of 7
Michael H. Shaw, Brown University, USA
Negative Feedback Regulation of Local Th1 Immunity by IFN-gamma Induced ICOSL-Dependent Reactivation of IL-10

Tuesday, January 10 | 2:30PM - 4:30PM
Workshop 3: Immunoregulation and Immune Evasion in Infectiou
s Diseases
Room: Red Cloud Peak

Speaker 4 of 7
* Merilyn H. Hibma, University of Otago, New Zealand
Human Papillomavirus Type 16 E6 Protein Reduces Cell Surface E-Cadherin: A Mechanism for Viral Immune Evasion

Tuesday, January 10 | 2:30PM - 4:30PM
Workshop 3: Immunoregulation and Immune Evasion in Infectiou
s Diseases
Room: Red Cloud Peak

Speaker 5 of 7
* Jean Langhorne, Francis Crick Institute, UK
Activation of CD4 T Cells by Different Populations of Splenic Dendritic Cells In Vivo in a Model of Malaria

Tuesday, January 10 | 2:30PM - 4:30PM
Workshop 3: Immunoregulation and Immune Evasion in Infectiou
s Diseases
Room: Red Cloud Peak

Speaker 6 of 7
Shabaana A. Khader, Washington University School of Medicine, USA
IL-12p40 Homodimer is Required for Dendritic Cell Migration and T Cell Priming Following Mycobacterium Tuberculosis Infection of the Lung

Tuesday, January 10 | 2:30PM - 4:30PM
Workshop 3: Immunoregulation and Immune Evasion in Infectiou
s Diseases
Room: Red Cloud Peak

Speaker 7 of 7
Bo Wu, Stanford University, USA
Measurment of FOXP3 MRNA Distiguishes Active from Latent Mtb Infections

Tuesday, January 10 | 4:30PM - 5:00PM
Coffee Available
Room: Shavano Peak Foyer


Tuesday, January 10 | 5:00PM - 6:20PM
Influenza Still Plagues us After A Century - Implications fo
r Host Responses to New and Emerging Viruses such as Severe Acute Respiratory Syndrome (SARS)

Room: Crestone Peak

Speaker 1 of 2
* Kanta Subbarao, WHO Collaborating Centre for Reference and Research on Influenza, Australia
Host Responses to Avian Influenza and SARS: Implications for Vaccine Development

Tuesday, January 10 | 5:00PM - 6:20PM
Influenza Still Plagues us After A Century - Implications fo
r Host Responses to New and Emerging Viruses such as Severe Acute Respiratory Syndrome (SARS)

Room: Crestone Peak

Speaker 2 of 2
Herbert (Skip) W. Virgin, Vir Biotechnology, USA
Innate and Acquired Immunity to a Novel Norovirus in Mice

Tuesday, January 10 | 6:20PM - 7:00PM
Future of Research in the Immunology of Infectious Disease
Room: Crestone Peak

Speaker 1 of 1
Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA
Blood Leukocyte Transcriptional Fingerprints as Novel Diagnostic and Prognostic Indicators

Tuesday, January 10 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Castle Peaks


Wednesday, January 11 | 10:26AM - 10:26AM
Departure


*Session Chair.