Web Desc
Protein Misfolding Diseases: Mechanisms of Misfolding, Pathology and Therapeutic Strategies
joint with Alzheimer's Disease: Genes, Cellular Pathways and Therapies
Organizer(s): Jeffery W. Kelly and Susan L. Lindquist
Date: February 21 - 26, 2006
Location: Beaver Run Resort, Breckenridge, CO, USA
Supported by the Director's Fund
Summary of Meeting:
This meeting, designed to run in parallel with the Alzheimer's meeting, focuses on both intra- and extracellular misfolding diseases, most of which are associated with neurodegeneration. The program commences with an overview of folding and misfolding mechanisms and proceeds to outline what is know about several related pathologies and outlines novel therapeutic intervention strategies. Each session features a novel concept talk, which overviews a departure from current thinking. The integrated scientific nature of this meeting is essential to intervene in and understand these disorders representing the most costly contemporary health problem.
Scholarship Deadline: October 20 2005
Discounted Abstract Deadline: October 20 2005
Abstract Deadline: November 14 2005
Discounted Registration Deadline: December 21 2005
We gratefully acknowledge additional support for this conference from:
Novartis Institutes for BioMedical Research
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Neurological Disorders and Stroke (NINDS)
Grant No. 1R13 NS054459-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Tuesday, February 21 | 3:00PM - 7:30PM
Registration
Room: Foyer


Tuesday, February 21 | 6:30PM - 7:30PM
Refreshments
Room: Foyer


Tuesday, February 21 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Peaks 1-5

Speaker 1 of 4
* Rudolph E. Tanzi, Massachusetts General Hospital, USA

Tuesday, February 21 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Peaks 1-5

Speaker 2 of 4
Sangram S. Sisodia, University of Chicago, USA
Molecular Neurobiology of Alzheimer's Disease

Tuesday, February 21 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Peaks 1-5

Speaker 3 of 4
Cynthia Kenyon, Calico, USA
Insulin/IGF-1 Signaling, Polyglutamine Aggregation and Aging in C. elegans

Tuesday, February 21 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Peaks 1-5

Speaker 4 of 4
* Jeffery W. Kelly, The Scripps Research Institute, USA

Wednesday, February 22 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Wednesday, February 22 | 8:00AM - 11:00AM
Functional Amyloidogenesis
Room: Peak 5

Speaker 1 of 5
Susan Lindquist, HHMI/Whitehead Institute for Biomedical Research, USA
A Yeast Prion Provides a Mechanism for Phenotypic Plasticity

Wednesday, February 22 | 8:00AM - 11:00AM
Functional Amyloidogenesis
Room: Peak 5

Speaker 2 of 5
Martijn F.B.G. Gebbink, University Medical Center Utrecht, Netherlands
Activation of the Contact System and the Fibrinolytic System of Hemostasis by Amyloid Cross-beta Structure

Wednesday, February 22 | 8:00AM - 11:00AM
Functional Amyloidogenesis
Room: Peak 5

Speaker 3 of 5
Douglas M. Fowler, University of Washington, USA
The Role of Functional Amyloid Formation in Melanogenesis

Wednesday, February 22 | 8:00AM - 11:00AM
Functional Amyloidogenesis
Room: Peak 5

Speaker 4 of 5
* Matthew R. Chapman, University of Michigan, USA
Protein Misfolding Done Right: The Biogenesis of Bacterial Amyloid Fibers

Wednesday, February 22 | 8:00AM - 11:00AM
Functional Amyloidogenesis
Room: Peak 5

Speaker 5 of 5
Yakov A. Vitrenko, University of Illinois at Chicago, USA
Short Talk: Cross-Seeding between Yeast Sup35 and Rnq1 Prions Involves Formation of Aggregates Containing both Proteins

Wednesday, February 22 | 8:00AM - 11:00AM
Genetics and Epidemiology of AD
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 1 of 6
* Rudolph E. Tanzi, Massachusetts General Hospital, USA


Wednesday, February 22 | 8:00AM - 11:00AM
Genetics and Epidemiology of AD
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 2 of 6
Steven G. Younkin, Mayo Clinic Jacksonville, USA
Novel Susceptibility Alleles and Biomarkers for Late Onset AD


Wednesday, February 22 | 8:00AM - 11:00AM
Genetics and Epidemiology of AD
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 3 of 6
Mario H. Bengtson, Genomics Institute of Novartis Foundation, USA
Short Talk: Tauopathy Caused by Mutation of a Novel E3 Ubiquitin Ligase


Wednesday, February 22 | 8:00AM - 11:00AM
Genetics and Epidemiology of AD
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 4 of 6
Lars Bertram, Massachusetts General Hospital, USA
The Current Status of Alzheimer's Genetics Research


Wednesday, February 22 | 8:00AM - 11:00AM
Genetics and Epidemiology of AD
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 5 of 6
Ellen M. Wijsman, University of Washington, USA
Complex Models in the Search for Late-onset AD Genes


Wednesday, February 22 | 8:00AM - 11:00AM
Genetics and Epidemiology of AD
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 6 of 6
Lisa A. Paige, Metabolon Inc., USA
Short Talk: Comparative Metabolomic Analysis of Plasma from Patients with Alzheimer’s Disease or Mild Cognitive Impairment


Wednesday, February 22 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Wednesday, February 22 | 11:00AM - 1:00PM
Poster Setup
Room: Peaks 14-17


Wednesday, February 22 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 14-17


Wednesday, February 22 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Wednesday, February 22 | 5:00PM - 7:00PM
Mechanisms of Amyloidogenesis
Room: Peak 5

Speaker 1 of 4
Christopher M. Dobson, University of Cambridge, UK
Protein Folding, Molecular Evolution and Human Disease

Wednesday, February 22 | 5:00PM - 7:00PM
Mechanisms of Amyloidogenesis
Room: Peak 5

Speaker 2 of 4
Roland Riek, The Salk Institute, USA
3D Structures of Amyloid Fibrils of HET-s Prion and Alzheimer Abeta(1-42) fibrils)

Wednesday, February 22 | 5:00PM - 7:00PM
Mechanisms of Amyloidogenesis
Room: Peak 5

Speaker 3 of 4
* David Eisenberg, University of California, Los Angeles, USA
Crystal Structure Analyses of Amyloid-like Fibrils

Wednesday, February 22 | 5:00PM - 7:00PM
Mechanisms of Amyloidogenesis
Room: Peak 5

Speaker 4 of 4
Michael Hecht, Princeton University, USA
Short Talk: Sequence Determinants of the Aggregation of Alzheimer’s Peptide, Abeta42

Wednesday, February 22 | 5:00PM - 7:00PM
Amyloid Precursor Protein Function
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 1 of 5
* Christian Haass, Ludwig-Maximilians University Munich, Germany


Wednesday, February 22 | 5:00PM - 7:00PM
Amyloid Precursor Protein Function
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 2 of 5
Sam Gandy, Mount Sinai Medical Center, USA
Concentration of the Alzheimer Amyloid-beta Precursor Protein In the Neuronal trans-Golgi Network Elevates Abeta42, Mimicking the Effect of Mutant Presenilins


Wednesday, February 22 | 5:00PM - 7:00PM
Amyloid Precursor Protein Function
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 3 of 5
Roberto Malinow, University of California, San Diego, USA
AMPA-R: Role in AB induced Loss of Spines


Wednesday, February 22 | 5:00PM - 7:00PM
Amyloid Precursor Protein Function
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 4 of 5
Thomas C. Südhof, Stanford School of Medicine, USA
Alpha-Synuclein Cooperates with CSPalpha in Preventing Neurodegeneration


Wednesday, February 22 | 5:00PM - 7:00PM
Amyloid Precursor Protein Function
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 5 of 5
Constanze Reinhard, Center for Human Genetics, Belgium
Short Talk: Characterization of the sAPP Receptor(s)


Wednesday, February 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 14-17


Wednesday, February 22 | 7:30PM - 10:00PM
Poster Session 1
Room: Peaks 14-17


Thursday, February 23 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Thursday, February 23 | 8:00AM - 11:00AM
Protein Folding and Misfolding in Cells and Organisms
Room: Peak 5

Speaker 1 of 4
William E. Balch, The Scripps Research Institute, USA
Protein Misfolding and Folding in the Exocytic Pathway

Thursday, February 23 | 8:00AM - 11:00AM
Protein Folding and Misfolding in Cells and Organisms
Room: Peak 5

Speaker 2 of 4
Richard I. Morimoto, Northwestern University, USA
The Stress of isfolding Proteins: Aging and Neurodegenerative Disease

Thursday, February 23 | 8:00AM - 11:00AM
Protein Folding and Misfolding in Cells and Organisms
Room: Peak 5

Speaker 3 of 4
* Nancy M. Bonini, University of Pennsylvania, USA
Human Neurodegenerative Disease: Insights from Drosophila Genetics

Thursday, February 23 | 8:00AM - 11:00AM
Protein Folding and Misfolding in Cells and Organisms
Room: Peak 5

Speaker 4 of 4
Andrew G. Dillin, University of California, Berkeley, USA
The Genetics of Aging and Age Related Disease

Thursday, February 23 | 8:00AM - 11:15AM
Presenilin and Gamma Secretase
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 1 of 7
* Karen Duff, Columbia University, USA


Thursday, February 23 | 8:00AM - 11:15AM
Presenilin and Gamma Secretase
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 2 of 7
Dennis J. Selkoe, Harvard Medical School, USA
The Life Cycle of Amyloid ß-Protein: Mechanisms of Production Synaptotoxicity


Thursday, February 23 | 8:00AM - 11:15AM
Presenilin and Gamma Secretase
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 3 of 7
Christian Haass, Ludwig-Maximilians University Munich, Germany
A Common Proteolytic Mechanism For Intramembrane Proteolysis By GxGD-Type Aspartyl Proteases


Thursday, February 23 | 8:00AM - 11:15AM
Presenilin and Gamma Secretase
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 4 of 7
Bart De Strooper, University College London, UK
Genetic and Biochemical Analysis of the Gamma-Secretase Complexes in Mice


Thursday, February 23 | 8:00AM - 11:15AM
Presenilin and Gamma Secretase
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 5 of 7
Jie Shen, Harvard Medical School, USA
Presenilins in Pre- and Post- Synaptic Plasticity and Neurodegeneration


Thursday, February 23 | 8:00AM - 11:15AM
Presenilin and Gamma Secretase
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 6 of 7
Homira Behbahani, Karolinska Institutet, Sweden
Short Talk: Differential Role of Presenilin-1 and -2 on Mitochondrial Membrane Potential and Oxygen Consumption in Mouse Embryonic Fibroblasts


Thursday, February 23 | 8:00AM - 11:15AM
Presenilin and Gamma Secretase
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 7 of 7
Taisuke Tomita, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
Short Talk: The Mechanism of gamma-Secretase-Mediated Cleavage Probed by Small Molecule Compounds


Thursday, February 23 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Thursday, February 23 | 11:00AM - 1:00PM
Poster Setup
Room: Peaks 14-17


Thursday, February 23 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 14-17


Thursday, February 23 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Thursday, February 23 | 5:00PM - 7:00PM
Therapeutic Strategies Towards Misfolding Diseases
Room: Peak 5

Speaker 1 of 4
Jeffery W. Kelly, The Scripps Research Institute, USA
Towards Understanding and Ameliorating Protein Misfolding Disease

Thursday, February 23 | 5:00PM - 7:00PM
Therapeutic Strategies Towards Misfolding Diseases
Room: Peak 5

Speaker 2 of 4
Michel Bouvier, University of Montreal, Canada
Molecular Mechanisms of Action and Therapeutic Potential of Pharmacological Chaperones on Misfolded G Protein-Coupled Receptors

Thursday, February 23 | 5:00PM - 7:00PM
Therapeutic Strategies Towards Misfolding Diseases
Room: Peak 5

Speaker 3 of 4
* Leslie M. Thompson, University of California, Irvine, USA
Therapeutic Strategies for Huntington’s Disease

Thursday, February 23 | 5:00PM - 7:00PM
Therapeutic Strategies Towards Misfolding Diseases
Room: Peak 5

Speaker 4 of 4
Aaron D. Gitler, Stanford University School of Medicine, USA
Short Talk: Alpha-Synuclein Toxicity Involves Inhibition of Endoplasmic Reticulum (ER) to Golgi Trafficking

Thursday, February 23 | 5:00PM - 7:00PM
Beta-Secretase
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 1 of 5
* Dennis J. Selkoe, Harvard Medical School, USA


Thursday, February 23 | 5:00PM - 7:00PM
Beta-Secretase
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 2 of 5
Donald L. Price, Johns Hopkins University, USA
Neurodegenerative Diseases: Models, Mechanisms and Experimental Therapeutics


Thursday, February 23 | 5:00PM - 7:00PM
Beta-Secretase
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 3 of 5
Jordan J. Tang, Oklahoma Medical Research Foundation, USA
Cellular Trafficking of Memapsin 2 and APP Mediated by Protein Factors


Thursday, February 23 | 5:00PM - 7:00PM
Beta-Secretase
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 4 of 5
Edward B. Lee, Hospital of the University of Pennsylvania, USA
BACE Activity and the Subcellular Localization of APP Cleavage


Thursday, February 23 | 5:00PM - 7:00PM
Beta-Secretase
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 5 of 5
Michael Willem, Adolf-Butenandt-Institute, Germany
Short Talk: Functional Analysis of BACE1


Thursday, February 23 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 14-17


Thursday, February 23 | 7:30PM - 10:00PM
Poster Session 2
Room: Peaks 14-17


Friday, February 24 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Friday, February 24 | 8:00AM - 11:00AM
Cellular Mechanisms for Handling Misfolded Proteins
Room: Peak 5

Speaker 1 of 4
Eva-Maria Mandelkow, Max Planck Institut, Germany
Tau Protein Structure and Aggregation

Friday, February 24 | 8:00AM - 11:00AM
Cellular Mechanisms for Handling Misfolded Proteins
Room: Peak 5

Speaker 2 of 4
* Randy Y. Hampton, University of California, San Diego, USA
ERAD as a Strategy of Protein Quantity Control

Friday, February 24 | 8:00AM - 11:00AM
Cellular Mechanisms for Handling Misfolded Proteins
Room: Peak 5

Speaker 3 of 4
Jonathan S. Weissman, Whitehead Institute and MIT, USA
A Novel Branch of the Unfolded Protein Response

Friday, February 24 | 8:00AM - 11:00AM
Cellular Mechanisms for Handling Misfolded Proteins
Room: Peak 5

Speaker 4 of 4
Randal J. Kaufman, Sanford-Burnham Medical Research Institute, USA
The Unfolded Protein Response: A Link between ER Stress and Inflammation

Friday, February 24 | 8:00AM - 11:15AM
Tau and FTD
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 1 of 6
Lester I. Binder, Northwestern University, USA
Tau Alterations in Alzheimer's Disease


Friday, February 24 | 8:00AM - 11:15AM
Tau and FTD
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 2 of 6
Karen Duff, Columbia University, USA
Phosphorylation as a Pathogenic Mechanism in AD


Friday, February 24 | 8:00AM - 11:15AM
Tau and FTD
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 3 of 6
Eva-Maria Mandelkow, Max Planck Institut, Germany
The Modes and Pathways of Tau's Toxicity to Neurons in Neurodegeneration


Friday, February 24 | 8:00AM - 11:15AM
Tau and FTD
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 4 of 6
Michael Hutton, Eli Lilly Research Center, UK
Genetics of the Tauopathies


Friday, February 24 | 8:00AM - 11:15AM
Tau and FTD
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 5 of 6
Chad A. Dickey, University of South Florida, USA
Short Talk: Deletion of CHIP Leads to Caspase-3 Activation and Neuronal Apoptosis Associated with Increases in Non-Ubiquitinated, Soluble Phospho-Tau Species without Neurofibrillary Tangles


Friday, February 24 | 8:00AM - 11:15AM
Tau and FTD
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 6 of 6
Kun Ping Lu, Beth Israel Deaconess Medical Center, USA
Short Talk: The Isomerase Pin1: a Potential New Link between Tangle and Plaque Pathologies of Alzheimer’s Disease


Friday, February 24 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Friday, February 24 | 11:00AM - 1:00PM
Poster Setup
Room: Peaks 14-17


Friday, February 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Peaks 14-17


Friday, February 24 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Friday, February 24 | 5:00PM - 7:00PM
The Response to Damaged Proteins
Room: Peak 5

Speaker 1 of 4
* Susan Lindquist, HHMI/Whitehead Institute for Biomedical Research, USA

Friday, February 24 | 5:00PM - 7:00PM
The Response to Damaged Proteins
Room: Peak 5

Speaker 2 of 4
Paul Wentworth, Jr., The Scripps Research Institute, USA
Oxidative Metabolite Triggered Protein Misfolding

Friday, February 24 | 5:00PM - 7:00PM
The Response to Damaged Proteins
Room: Peak 5

Speaker 3 of 4
Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Autophagy in Aging: The Importance of Maintaining Cells Clean

Friday, February 24 | 5:00PM - 7:00PM
The Response to Damaged Proteins
Room: Peak 5

Speaker 4 of 4
Claudio A. Hetz, University of Chile, Chile
Short Talk: Proapoptotic BAX and BAK Modulate the Unfolded Protein Response through a Direct Interaction with Ire1alpha

Friday, February 24 | 5:00PM - 7:00PM
Abeta Clearance
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 1 of 5
* Cynthia A. Lemere, Brigham and Women's Hospital, Harvard Medical School, USA


Friday, February 24 | 5:00PM - 7:00PM
Abeta Clearance
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 2 of 5
David M. Holtzman, Washington University, USA
Effects of ApoE Levels, Isoform, and Lipidation on CNS Abeta Clearance and Fibrillogenesis


Friday, February 24 | 5:00PM - 7:00PM
Abeta Clearance
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 3 of 5
Berislav Zlokovic, University of Southern California, USA
Neurovascular Mechanisms and Targets in AD


Friday, February 24 | 5:00PM - 7:00PM
Abeta Clearance
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 4 of 5
Louis B. Hersh, University of Kentucky, USA
AB Degrading Peptidases


Friday, February 24 | 5:00PM - 7:00PM
Abeta Clearance
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 5 of 5
Matthew Townsend, Brigham and Women's Hospital, USA
Short Talk: The Cyclohexanehexol, AZD-103, Neutralizes Cell-derived ABeta Oligomers and Rescues Hippocampal Long-Term Potentiation


Friday, February 24 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 14-17


Friday, February 24 | 7:30PM - 10:00PM
Poster Session 3
Room: Peaks 14-17


Saturday, February 25 | 7:00AM - 8:00AM
Breakfast
Room: Peaks 6-12


Saturday, February 25 | 8:00AM - 9:30AM
Emerging Misfolding Diseases
Room: Peak 5

Speaker 1 of 3
Gunilla T. Westermark, Linköping University, Sweden
Islet Amyloid and Beta Cell Destruction in Diabetes

Saturday, February 25 | 8:00AM - 9:30AM
Emerging Misfolding Diseases
Room: Peak 5

Speaker 2 of 3
Marina Ramirez-Alvarado, Mayo Clinic College of Medicine, USA
Light Chain Amyloidosis-When Elevated Amounts of Protein, Multiple Mutations, Proteolytic Cleavage, and Loss of Associations Come Together

Saturday, February 25 | 8:00AM - 9:30AM
Emerging Misfolding Diseases
Room: Peak 5

Speaker 3 of 3
Matthew J. Trifilo, The Scripps Research Institute, USA
Short Talk: Conversion of PrPsen to PrPres and Extraneural Disease Associated with Amyloidogenic PrPres Deposits Occur in the Absence of PrP’s GPI Anchor

Saturday, February 25 | 8:00AM - 11:15AM
Animal Models and Therapeutics
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 1 of 7
* Sam Gandy, Mount Sinai Medical Center, USA


Saturday, February 25 | 8:00AM - 11:15AM
Animal Models and Therapeutics
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 2 of 7
Cynthia A. Lemere, Brigham and Women's Hospital, Harvard Medical School, USA
Modulating the Immune Response in Abeta Immunotherapy


Saturday, February 25 | 8:00AM - 11:15AM
Animal Models and Therapeutics
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 3 of 7
Charles G. Glabe, University of California, Irvine, USA
Immunization of transgenic mouse models of degenerative disease against amyloid oligomers.


Saturday, February 25 | 8:00AM - 11:15AM
Animal Models and Therapeutics
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 4 of 7
Dora M. Kovacs, Massachusetts General Hospital, USA
Cholesterol-Related AD Therapeutics


Saturday, February 25 | 8:00AM - 11:15AM
Animal Models and Therapeutics
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 5 of 7
Abraham Fisher, Israel Institute for Biological Research, Israel
M1 Muscarinic Agonists - Promising Agents on Major Hallmarks of Alzheimer's Disease


Saturday, February 25 | 8:00AM - 11:15AM
Animal Models and Therapeutics
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 6 of 7
Steven E. Jacobsen, University of California, Los Angeles, USA
Short Talk: Preclincal and Behavioral Models of Alzheimer’s Disease Passive Immunotherapy


Saturday, February 25 | 8:00AM - 11:15AM
Animal Models and Therapeutics
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 7 of 7
Thomas A. Bayer, University of Saarland, Germany
Short Talk: Intraneuronal Aß, Neuron Loss and Axonopathy in Transgenic Mouse Models for Alzheimer's Disease


Saturday, February 25 | 9:20AM - 9:40AM
Coffee Break
Room: Foyer


Saturday, February 25 | 9:50AM - 11:00AM
Organismal Models of Protein Misfolding Diseases
Room: Peak 5

Speaker 1 of 2
* Marie-Francoise Chesselet, University of California, Los Angeles, USA
Mouse Models of Parkinson’s and Huntington’s Disease

Saturday, February 25 | 9:50AM - 11:00AM
Organismal Models of Protein Misfolding Diseases
Room: Peak 5

Speaker 2 of 2
Don W. Cleveland, University of California, San Diego, USA
From Charcot to Lou Gehrig: The Unfolding Story in Mechanism and Treatment of ALS

Saturday, February 25 | 4:30PM - 5:00PM
Coffee Available
Room: Foyer


Saturday, February 25 | 5:00PM - 7:00PM
Emerging Topics Session: Short Talks Selected from Abstracts
Room: Peak 5

Speaker 1 of 8
* Matthew J. Trifilo, The Scripps Research Institute, USA

Saturday, February 25 | 5:00PM - 7:00PM
Emerging Topics Session: Short Talks Selected from Abstracts
Room: Peak 5

Speaker 2 of 8
Abraham Grossman, Q-RNA.com, USA
Small RNA Chaperones Facilitate Amyloid Protein Transformation in vitro and Lead to Aggregate Formation and Behavior Abnormalities in Drosophila

Saturday, February 25 | 5:00PM - 7:00PM
Emerging Topics Session: Short Talks Selected from Abstracts
Room: Peak 5

Speaker 3 of 8
Christopher D. Link, University of Colorado, USA
Cellular Toxicity of Aggregating Proteins

Saturday, February 25 | 5:00PM - 7:00PM
Emerging Topics Session: Short Talks Selected from Abstracts
Room: Peak 5

Speaker 4 of 8
Soumya S. Ray, Schrödinger, USA
Designing Aggregation Inhibitors of Superoxide Dismutase Mutants Linked to ALS

Saturday, February 25 | 5:00PM - 7:00PM
Emerging Topics Session: Short Talks Selected from Abstracts
Room: Peak 5

Speaker 5 of 8
Leila M. Luheshi, University of Cambridge, UK
Can we Predict the in Vivo Aggregation and Toxicity of AB 1-42 Mutants From their Intrinsic Aggregation Propensities?

Saturday, February 25 | 5:00PM - 7:00PM
Emerging Topics Session: Short Talks Selected from Abstracts
Room: Peak 5

Speaker 6 of 8
Shohei Koide, New York University Langone Health, USA
Short Talk: High Resolution Structures of Peptide Self-Assemblers

Saturday, February 25 | 5:00PM - 7:00PM
Emerging Topics Session: Short Talks Selected from Abstracts
Room: Peak 5

Speaker 7 of 8
Rajaraman Krishnan, Proclara Biosciences, USA
Short Talk: Structural Insights on a Yeast Prion Illuminate Necleation and Strain Diversity

Saturday, February 25 | 5:00PM - 7:00PM
Emerging Topics Session: Short Talks Selected from Abstracts
Room: Peak 5

Speaker 8 of 8
Jessie Chu, The Scripps Research Institute, USA
Short Talk: A Novel E3 Ubiquitin Ligase Involvd in Neurodegeneration

Saturday, February 25 | 5:00PM - 7:00PM
Therapeutics and Imaging
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 1 of 5
* Charles G. Glabe, University of California, Irvine, USA


Saturday, February 25 | 5:00PM - 7:00PM
Therapeutics and Imaging
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 2 of 5
Edward Koo, University of California, San Diego, USA
APP Function and Effects of NSAIDs


Saturday, February 25 | 5:00PM - 7:00PM
Therapeutics and Imaging
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 3 of 5
Christoph Hock, University of Zurich, Switzerland
Biomarkers for Alzheimer's Disease


Saturday, February 25 | 5:00PM - 7:00PM
Therapeutics and Imaging
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 4 of 5
Chester Mathis, UPMC Presbyterian Hospital, USA
Imaging beta-Amyloid in vivo


Saturday, February 25 | 5:00PM - 7:00PM
Therapeutics and Imaging
This session is from Alzheimer's Disease
Room: Peaks 1 - 4

Speaker 5 of 5
Ward Pedersen, Creighton University Medical Center, USA
Short Talk: Rosiglitazone Attenuates Glucocorticoid-Induced Learning and Memory Deficits in Tg2576 Alzheimer Mice


Saturday, February 25 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: Peaks 14-17


Saturday, February 25 | 8:00PM - 11:00PM
Entertainment
Room: Peaks 14-17


Saturday, February 25 | 8:00PM - 11:00PM
Cash Bar
Room: Peaks 14-17


Sunday, February 26 | 10:26AM - 10:26AM
Departure


*Session Chair.