Web Desc
Toward Understanding Islet Biology
joint with Pancreatic Islets: From Development to Transplantation
Organizer(s): Lydia Aguilar-Bryan, Bo Ahrén and Christopher B. Newgard
Date: February 23 - 28, 2006
Location: Sagebrush Inn & Suites, Taos, NM, USA
Supported by The Director's Fund
Summary of Meeting:
The past decade has seen a burgeoning of interest in the biology of the pancreatic islets of Langerhans. The surge in activity is driven in large measure by the rapid increase in the incidence of diabetes, and the critical role of failure of the insulin secreting cells (beta-cells) within the pancreatic islets in the pathogenesis of both major forms of the disease. This symposium will focus specifically on mechanisms of beta-cell failure in type 2 diabetes, which is fast becoming an epidemic disease world-wide (estimated prevalence in the United States alone, 18 million people). Beta-cell failure is now recognized as the event that triggers the transition from pre-diabetes/metabolic syndrome to full-blown type 2 diabetes. Major advances have occurred in our understanding of fundamental beta-cell biology, mechanisms of loss of function and loss of beta-cell mass in type 2 diabetes, and development of new strategies for enhancing beta-cell survival and function in diabetic animals and humans. These advances deserve careful review and discussion in the form of a Keystone symposium to which we expect to attract the very best scientists in the field. These recent advances in knowledge have occurred based on contributions of academic and industrial contributors alike, and our meeting includes invitations to key contributors from both sectors. The meeting will be divided into three major sections: A) Review of recent progress in understanding basic beta-cell biology, including mechanisms of fuel-stimulated insulin secretion and the role of receptor-mediated processes in potentiation of fuel-driven responses; B) Mechanisms of beta-cell dysfunction and destruction in response to metabolic fuel imbalance, including the roles of hyperlipidemia, hyperglycemia, and stress responses; C) Targets for improvement of beta cell function and new technological approaches. In sum, we believe that this program will be a timely and valuable contributor to advancement of a research field that is just beginning to achieve peak visibility and medical relevance.
Scholarship Deadline: October 24 2005
Discounted Abstract Deadline: October 24 2005
Abstract Deadline: November 16 2005
Discounted Registration Deadline: December 23 2005
We gratefully acknowledge additional support for this conference from:
JDRF
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

GlaxoSmithKline

Hoffmann-La Roche, Inc.

Merck Research Laboratories
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1R13 DK074221-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Thursday, February 23 | 3:00PM - 7:30PM
Registration
Room: Chamisa Lobby


Thursday, February 23 | 6:30PM - 7:30PM
Refreshments
Room: Chamisa Lobby


Thursday, February 23 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Chamisa Ballroom

Speaker 1 of 4
* Lydia Aguilar-Bryan, Pacific Northwest Research Institute, USA

Thursday, February 23 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Chamisa Ballroom

Speaker 2 of 4
* Alvin C. Powers, Vanderbilt University School of Medicine, USA

Thursday, February 23 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Chamisa Ballroom

Speaker 3 of 4
Philip F. Smith, NIDDK, National Institutes of Health, USA
The NIDDK Agenda for Research on Islet Development, Biology and Transplantation

Thursday, February 23 | 7:30PM - 9:30PM
Keynote Session (Joint)
Room: Chamisa Ballroom

Speaker 4 of 4
Philippe A. Halban, Geneva University, Switzerland
Connecting Beta Cell Biology to Effective Therapies for Type 1 and Type 2 Diabetes

Friday, February 24 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Friday, February 24 | 8:00AM - 11:00AM
Joint Session with the Transplantation Meeting
Room: Chamisa Ballroom

Speaker 1 of 5
* Chris Wright, Vanderbilt University Medical Center, USA

Friday, February 24 | 8:00AM - 11:00AM
Joint Session with the Transplantation Meeting
Room: Chamisa Ballroom

Speaker 2 of 5
* Christopher B. Newgard, Duke University Medical Center, USA
Metabolic networks of the mature beta-cell

Friday, February 24 | 8:00AM - 11:00AM
Joint Session with the Transplantation Meeting
Room: Chamisa Ballroom

Speaker 3 of 5
Frans C. Schuit, Katholieke Universiteit Leuven, Belgium
Molecular Mechanism of Food Intake-Dependent Fluctuations in the Functional Beta Cell Mass

Friday, February 24 | 8:00AM - 11:00AM
Joint Session with the Transplantation Meeting
Room: Chamisa Ballroom

Speaker 4 of 5
Markus Stoffel, ETH Zürich, Switzerland
Role of Micro RNAs in Islet Function

Friday, February 24 | 8:00AM - 11:00AM
Joint Session with the Transplantation Meeting
Room: Chamisa Ballroom

Speaker 5 of 5
Roger H. Unger, University of Texas Southwestern Medical Center, USA
Metabolic “Rejection” of Intraportal Islet Transplants: Evidence for Lipotoxic Destruction of Islets by Hepatic Lipids and its Prevention by Leptinization

Friday, February 24 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Friday, February 24 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 1


Friday, February 24 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 1


Friday, February 24 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Friday, February 24 | 5:00PM - 7:15PM
Regulation of Insulin Secretion I
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Christopher J. Rhodes, AstraZeneca, USA

Friday, February 24 | 5:00PM - 7:15PM
Regulation of Insulin Secretion I
Room: Chamisa Ballroom 1

Speaker 2 of 6
Kenneth S. Polonsky, Washington University School of Medicine, USA
Pancreatic beta cell survival: critical roles of pdx-1 and insulin

Friday, February 24 | 5:00PM - 7:15PM
Regulation of Insulin Secretion I
Room: Chamisa Ballroom 1

Speaker 3 of 6
Jean Claude Henquin, University of Louvain, Belgium
Triggering and amplifying pathways of glucose-stimulated insulin secretion: how and when?

Friday, February 24 | 5:00PM - 7:15PM
Regulation of Insulin Secretion I
Room: Chamisa Ballroom 1

Speaker 4 of 6
Joseph Bryan, Pacific Northwest Research Institute, USA
Alpha-/Beta-cell Crosstalk

Friday, February 24 | 5:00PM - 7:15PM
Regulation of Insulin Secretion I
Room: Chamisa Ballroom 1

Speaker 5 of 6
Thomas C. Becker, Duke University Medical Center, USA
Short Talk: Micro RNA ad B Cell Function

Friday, February 24 | 5:00PM - 7:15PM
Regulation of Insulin Secretion I
Room: Chamisa Ballroom 1

Speaker 6 of 6
Savita Dhanvantari, Lawson Research Health Institute, Canada
Short Talk: Cellular and Molecular Imaging of Pancreatic Islet Cells

Friday, February 24 | 5:00PM - 7:15PM
Challenges for Islet Transplantation
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 1 of 6
* Gordon C. Weir, Joslin Diabetes Center, USA


Friday, February 24 | 5:00PM - 7:15PM
Challenges for Islet Transplantation
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 2 of 6
David M. Harlan, National Institutes of Health, NIDDK, USA
Immune Aspects of Type 1 Diabetes and Islet Transplantation


Friday, February 24 | 5:00PM - 7:15PM
Challenges for Islet Transplantation
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 3 of 6
R. Paul Robertson, Pacific Northwest Research Institute, USA
What is a 'Successful' Islet Transplant?


Friday, February 24 | 5:00PM - 7:15PM
Challenges for Islet Transplantation
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 4 of 6
Daniel Nyqvist, Karolinska Institute, Sweden
Short Talk: 3D Visualization and Quantification of the Intact Islet Graft Vasculature


Friday, February 24 | 5:00PM - 7:15PM
Challenges for Islet Transplantation
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 5 of 6
Francis C. Lynn, University of British Columbia, Canada
Short Talk: MicroRNA Expression is Necessary for Normal Pancreas Development.


Friday, February 24 | 5:00PM - 7:15PM
Challenges for Islet Transplantation
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 6 of 6
Olle Korsgren, Uppsala University, Sweden
Inflammatory Events after Islet Transplantation


Friday, February 24 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Chamisa Lobby


Friday, February 24 | 7:30PM - 10:00PM
Poster Session 1
Room: Chamisa Ballroom 1


Saturday, February 25 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Saturday, February 25 | 8:00AM - 11:15AM
Regulation of Insulin Secretion II
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Joseph Bryan, Pacific Northwest Research Institute, USA

Saturday, February 25 | 8:00AM - 11:15AM
Regulation of Insulin Secretion II
Room: Chamisa Ballroom 1

Speaker 2 of 7
Christopher J. Rhodes, AstraZeneca, USA
Trafficking ß-Granule Trafficking

Saturday, February 25 | 8:00AM - 11:15AM
Regulation of Insulin Secretion II
Room: Chamisa Ballroom 1

Speaker 3 of 7
Franz M. Matschinsky, University of Pennsylvania, USA
Glutamine metabolism and Insulin Release

Saturday, February 25 | 8:00AM - 11:15AM
Regulation of Insulin Secretion II
Room: Chamisa Ballroom 1

Speaker 4 of 7
Marc Prentki, Montreal Diabetes Research Center, Canada
Glucose and Fuel-Stimulated Lipolysis, TG/FFA Cycling and Lipid Signaling for Insulin Secretion in Pancreatic B Cells

Saturday, February 25 | 8:00AM - 11:15AM
Regulation of Insulin Secretion II
Room: Chamisa Ballroom 1

Speaker 5 of 7
Celia Briscoe, Johnson and Johnson, USA
Fatty Acids as Extra-cellular Regulators of Insulin Secretion

Saturday, February 25 | 8:00AM - 11:15AM
Regulation of Insulin Secretion II
Room: Chamisa Ballroom 1

Speaker 6 of 7
Hassan Mziaut, Medical School TU Dresden, Germany
Short Talk: Synergy of Glucose and GH Signaling in Islet B Cells via ICA5/2

Saturday, February 25 | 8:00AM - 11:15AM
Regulation of Insulin Secretion II
Room: Chamisa Ballroom 1

Speaker 7 of 7
Alan D. Attie, University of Wisconsin-Madison, USA
Short Talk: Positional Cloning of a Type 2 Diabetes Quantitative Trait Gene

Saturday, February 25 | 8:00AM - 11:15AM
Pancreas and Islet Development
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 1 of 7
* George K. Gittes, Children's Hospital of Pittsburgh of UPMC, USA


Saturday, February 25 | 8:00AM - 11:15AM
Pancreas and Islet Development
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 2 of 7
Michael German, University of California, San Francisco, USA
Gene Expression Cascades in Islet Development


Saturday, February 25 | 8:00AM - 11:15AM
Pancreas and Islet Development
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 3 of 7
Chris Wright, Vanderbilt University Medical Center, USA
Pdx-1 Level is Instructive for Pancreatic Differentiation


Saturday, February 25 | 8:00AM - 11:15AM
Pancreas and Islet Development
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 4 of 7
Paul E. Harris, Columbia University, USA
Short Talk: Targeting Vesicular Monoamine Transporter Type 2 for Non-Invasive Longitudinal P.E.T. Studies of Beta Cell Mass Change


Saturday, February 25 | 8:00AM - 11:15AM
Pancreas and Islet Development
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 5 of 7
Lori Sussel, University of Colorado Anschutz Medical Campus, USA
Pathways of Islet Cell Differentiation and Development


Saturday, February 25 | 8:00AM - 11:15AM
Pancreas and Islet Development
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 6 of 7
Jared S. Burlison, Vanderbilt University School of Medicine, USA
Short Talk: Genetic Labelling of PtF/a Expressing Cells


Saturday, February 25 | 8:00AM - 11:15AM
Pancreas and Islet Development
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 7 of 7
Kenneth S. Zaret, University of Pennsylvania, USA
Specifying Pancreas and Liver Cells in Development


Saturday, February 25 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Saturday, February 25 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 1


Saturday, February 25 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 1


Saturday, February 25 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Saturday, February 25 | 5:00PM - 7:15PM
Role of Mitochondrial Metabolism in Health and Disease
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Jack Leahy, University of Vermont, USA

Saturday, February 25 | 5:00PM - 7:15PM
Role of Mitochondrial Metabolism in Health and Disease
Room: Chamisa Ballroom 1

Speaker 2 of 6
John A. Corbett, Medical College of Wisconsin, USA
A Transgenic Approach to Study the Role of mtDNA Mutations in Pancreatic b-cell Failure

Saturday, February 25 | 5:00PM - 7:15PM
Role of Mitochondrial Metabolism in Health and Disease
Room: Chamisa Ballroom 1

Speaker 3 of 6
Claes B. Wollheim, University of Geneva Medical Centre, Switzerland
Defective Beta-Cell Mitochondrial Signalling is Restored by the Nuclear Factor TFAM or by Matrix Calcium Elevation.

Saturday, February 25 | 5:00PM - 7:15PM
Role of Mitochondrial Metabolism in Health and Disease
Room: Chamisa Ballroom 1

Speaker 4 of 6
Donalyn Scheuner, University of Michigan, USA
Signaling the Unfolded Protein Response Protects the Endoplasmic Reticulum Compartment and Prevents Beta Cell Failure

Saturday, February 25 | 5:00PM - 7:15PM
Role of Mitochondrial Metabolism in Health and Disease
Room: Chamisa Ballroom 1

Speaker 5 of 6
Cedric Le May, Baylor College of Medicine, USA
Short Talk: Estrogens Protect Pancreatic Beta-Cells From Apoptosis via Activation of the Estrogen Receptor-alpha and Prevent Insulin-Deficient Diabetes

Saturday, February 25 | 5:00PM - 7:15PM
Role of Mitochondrial Metabolism in Health and Disease
Room: Chamisa Ballroom 1

Speaker 6 of 6
Christine Bruun, Novo Nordisk A/S, Denmark
Short Talk: Proliferative and Anti-Apoptotic Signalling Pathways in Human Beta-Cells

Saturday, February 25 | 5:00PM - 7:15PM
Stem Cells and Pancreatic Islets
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 1 of 6
* Michael German, University of California, San Francisco, USA


Saturday, February 25 | 5:00PM - 7:15PM
Stem Cells and Pancreatic Islets
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 2 of 6
Gordon M. Keller, University Health Network, MaRS Centre, Canada
Commitment of ES Cells to Endoderm


Saturday, February 25 | 5:00PM - 7:15PM
Stem Cells and Pancreatic Islets
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 3 of 6
Sarah L. Londrigan, University of Melbourne, Australia
Short Talk: Prolonged Islet Allograft Survival by Modification Using Immunomodulatory Adenoviruses


Saturday, February 25 | 5:00PM - 7:15PM
Stem Cells and Pancreatic Islets
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 4 of 6
Laura Crisa, The Scripps Research Institute, USA
Short Talk: Enhaced Engraftment and Function of Pancreatic Islet Cell Transplants by Bone Marrow-Derived Blood Vessels


Saturday, February 25 | 5:00PM - 7:15PM
Stem Cells and Pancreatic Islets
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 5 of 6
Alan Colman, ES Cell International and A*STAR Center for Molecular Medicine, Singapore
Making Clinically Useful beta-Like Cells from Human Embryonic Stem Cells


Saturday, February 25 | 5:00PM - 7:15PM
Stem Cells and Pancreatic Islets
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 6 of 6
Norris Ray Dunn, Institute of Medical Biology, Singapore
Diabetes Cell Therapy from ES Cells


Saturday, February 25 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Chamisa Lobby


Saturday, February 25 | 7:30PM - 10:00PM
Poster Session 2
Room: Chamisa Ballroom 1


Sunday, February 26 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Sunday, February 26 | 8:00AM - 11:15AM
Pathways for Development of Beta Cell Dysfunction
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Frans C. Schuit, Katholieke Universiteit Leuven, Belgium

Sunday, February 26 | 8:00AM - 11:15AM
Pathways for Development of Beta Cell Dysfunction
Room: Chamisa Ballroom 1

Speaker 2 of 7
Jack Leahy, University of Vermont, USA
Mitochondrial Metabolism and Beta Cell Dysfunction

Sunday, February 26 | 8:00AM - 11:15AM
Pathways for Development of Beta Cell Dysfunction
Room: Chamisa Ballroom 1

Speaker 3 of 7
Vincent Poitout, Montreal Diabetes Research Center, Canada
Fatty-Acid Inhibition of Insulin Gene Expression.

Sunday, February 26 | 8:00AM - 11:15AM
Pathways for Development of Beta Cell Dysfunction
Room: Chamisa Ballroom 1

Speaker 4 of 7
Michele Solimena, Dresden University of Technology, Germany
Insulin Secretory Granule Biogenesis and Signaling

Sunday, February 26 | 8:00AM - 11:15AM
Pathways for Development of Beta Cell Dysfunction
Room: Chamisa Ballroom 1

Speaker 5 of 7
Michael J. MacDonald, University of Wisconsin-Madison, USA
Roles Of Mitochondrially Synthesized Products In Insulin Secretion

Sunday, February 26 | 8:00AM - 11:15AM
Pathways for Development of Beta Cell Dysfunction
Room: Chamisa Ballroom 1

Speaker 6 of 7
Jonathan C. Schisler, Duke University Medical Center, USA
Short Talk: The Transcription Factor Nkx6.1 Regulates Mature Beta-Cell Proliferation Through Control of Multiple Cell Cycle Genes

Sunday, February 26 | 8:00AM - 11:15AM
Pathways for Development of Beta Cell Dysfunction
Room: Chamisa Ballroom 1

Speaker 7 of 7
Helle Frobøse, Steno Diabetes Center, Denmark
Short Talk: IL-1 Signalling is Inhibited by Suppressor of Cytokine Signalling (SOCS)-3 Targeting The TRAF-6/TAK1 Complex

Sunday, February 26 | 8:00AM - 11:15AM
Current Status of Human Islet Transplantation
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 1 of 7
* Robert A. Rizza, Mayo Clinic and Foundation, USA


Sunday, February 26 | 8:00AM - 11:15AM
Current Status of Human Islet Transplantation
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 2 of 7
Mathias Brendel, University of Giessen, Germany
How do we Evaluate Islets prior to Transplantation?


Sunday, February 26 | 8:00AM - 11:15AM
Current Status of Human Islet Transplantation
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 3 of 7
Breay W. Paty, University of Alberta, Canada
Islet Transplantation: Learning from the Edmonton Experience


Sunday, February 26 | 8:00AM - 11:15AM
Current Status of Human Islet Transplantation
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 4 of 7
Camillo Ricordi, University of Miami School of Medicine, USA
Miami Initiatives for Improving Islet Transplantation


Sunday, February 26 | 8:00AM - 11:15AM
Current Status of Human Islet Transplantation
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 5 of 7
Bernhard J. Hering, University of Minnesota, USA
Single-Donor Islet Transplants


Sunday, February 26 | 8:00AM - 11:15AM
Current Status of Human Islet Transplantation
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 6 of 7
Lorna W. Harries, Peninsula Medical School, UK
Short Talk: Alternate mRNA Processing of the Hepatocyte Nuclear Factor –1 alpha (HNF-1alpha) Gene Impacts on Clinical Phenotype


Sunday, February 26 | 8:00AM - 11:15AM
Current Status of Human Islet Transplantation
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 7 of 7
David D. Lee, University of Chicago, USA
Short Talk: An Indirect Role for the Spleen in Functional Islet beta-Cell Regeneration


Sunday, February 26 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Sunday, February 26 | 11:15AM - 1:00PM
Poster Setup
Room: Chamisa Ballroom 1


Sunday, February 26 | 1:00PM - 10:00PM
Poster Viewing
Room: Chamisa Ballroom 1


Sunday, February 26 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Sunday, February 26 | 5:00PM - 7:15PM
Autonomic Regulation of Insulin Release
Room: Chamisa Ballroom 1

Speaker 1 of 5
Gary J. Schwartz, Albert Einstein College of Medicine, USA
Integrated Neural Control of Glucose Homeostasis

Sunday, February 26 | 5:00PM - 7:15PM
Autonomic Regulation of Insulin Release
Room: Chamisa Ballroom 1

Speaker 2 of 5
* Gerald J. Taborsky, Jr., Seattle VA Puget Sound Health Center, USA
Neural Control of Islet Function

Sunday, February 26 | 5:00PM - 7:15PM
Autonomic Regulation of Insulin Release
Room: Chamisa Ballroom 1

Speaker 3 of 5
* Bo Ahrén, Lund University, Sweden
Neuropeptides and Islet Function

Sunday, February 26 | 5:00PM - 7:15PM
Autonomic Regulation of Insulin Release
Room: Chamisa Ballroom 1

Speaker 4 of 5
Maria L. Golson, University of Pennsylvania, USA
Short Talk: Jagged1 is Required for Normal Cell Lineage Allocation in the Endocrine Pancreas

Sunday, February 26 | 5:00PM - 7:15PM
Autonomic Regulation of Insulin Release
Room: Chamisa Ballroom 1

Speaker 5 of 5
Nada Nekrep, University of California, San Francisco, USA
Short Talk: Target Genes of Nkx2.2 During Pancreatic Development and in Mature Beta Cells

Sunday, February 26 | 5:00PM - 7:15PM
Beta Cell - Birth and Death
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 1 of 6
* Kevin Docherty, University of Aberdeen, UK


Sunday, February 26 | 5:00PM - 7:15PM
Beta Cell - Birth and Death
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 2 of 6
Ray MacDonald, University of Texas Southwestern Medical Center, USA
Islet Formation at the Secondary Transition


Sunday, February 26 | 5:00PM - 7:15PM
Beta Cell - Birth and Death
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 3 of 6
Peter C. Butler, University of California, Los Angeles, USA
Beta Cell Turnover in Humans


Sunday, February 26 | 5:00PM - 7:15PM
Beta Cell - Birth and Death
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 4 of 6
Jake A. Kushner, Baylor College of Medicine, USA
Beta Cell Turnover in Mice


Sunday, February 26 | 5:00PM - 7:15PM
Beta Cell - Birth and Death
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 5 of 6
Maike Sander, University of California, San Diego, USA
Transcriptional Control of Pancreatic Cell Fate Determination


Sunday, February 26 | 5:00PM - 7:15PM
Beta Cell - Birth and Death
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 6 of 6
Lorella Marselli, Joslin Diabetes Center, USA
Short Talk: Evidence for Arrested Regeneration in Islets of Human Type 2 Diabetes


Sunday, February 26 | 7:15PM - 8:15PM
Social Hour with Lite Bites
Room: Chamisa Lobby


Sunday, February 26 | 7:30PM - 10:00PM
Poster Session 3
Room: Chamisa Ballroom 1


Monday, February 27 | 7:00AM - 8:00AM
Breakfast
Room: Los Vaqueros


Monday, February 27 | 8:00AM - 11:15AM
Emerging Technologies for Beta Cell Research
Room: Chamisa Ballroom 1

Speaker 1 of 7
* Christopher B. Newgard, Duke University Medical Center, USA

Monday, February 27 | 8:00AM - 11:15AM
Emerging Technologies for Beta Cell Research
Room: Chamisa Ballroom 1

Speaker 2 of 7
Mark A. Magnuson, Vanderbilt School of Medicine, USA
Multi-Allelic Gene Targeting Strategies and Their Application to Studies of Pancreas Development and Beta Cell Function

Monday, February 27 | 8:00AM - 11:15AM
Emerging Technologies for Beta Cell Research
Room: Chamisa Ballroom 1

Speaker 3 of 7
Klaus H. Kaestner, University of Pennsylvania School of Medicine, USA
Orthogonal Analysis of Transcriptional Programs in the Endocrine Pancreas: A Novel Role for the MODY1 Gene HNF4alpha

Monday, February 27 | 8:00AM - 11:15AM
Emerging Technologies for Beta Cell Research
Room: Chamisa Ballroom 1

Speaker 4 of 7
Dean Sherry, University of Texas at Dallas, USA
13C NMR Isotopomer Analysis Reveals Metabolic Details of Beta Cell Function

Monday, February 27 | 8:00AM - 11:15AM
Emerging Technologies for Beta Cell Research
Room: Chamisa Ballroom 1

Speaker 5 of 7
Anna Moore, Michigan State University, USA
Strategies for Molecular Imaging of Diabetic Pancreas

Monday, February 27 | 8:00AM - 11:15AM
Emerging Technologies for Beta Cell Research
Room: Chamisa Ballroom 1

Speaker 6 of 7
Kazuaki Ohtsubo, Kumamoto University, Japan
Short Talk: A Dietary and Genetic Mechanism of Pancreatic Beta Cell Failure in the Pathogenesis of Type 2 Diabetes

Monday, February 27 | 8:00AM - 11:15AM
Emerging Technologies for Beta Cell Research
Room: Chamisa Ballroom 1

Speaker 7 of 7
James Herrington, Merck & Co., Inc., USA
Short Talk: Inhibitors of the Pancreatic Beta-Cell Delayed Rectifier Potassium Current Enhance Insulin Secretion

Monday, February 27 | 8:00AM - 11:15AM
Moving from the Laboratory to Humans
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 1 of 7
* David M. Harlan, National Institutes of Health, NIDDK, USA


Monday, February 27 | 8:00AM - 11:15AM
Moving from the Laboratory to Humans
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 2 of 7
Daniel Pipeleers, Vrije Universiteit Brussel, Belgium
From Beta Cell Biology to Beta Cell Therapy - and Back


Monday, February 27 | 8:00AM - 11:15AM
Moving from the Laboratory to Humans
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 3 of 7
David W. Scharp, Prodo Laboratories, USA
Immunoisolation of Islets by Encapsulation


Monday, February 27 | 8:00AM - 11:15AM
Moving from the Laboratory to Humans
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 4 of 7
Masahito Matsumoto, Saitama Medical University, Japan
Short Talk: Identification of a Factor that Supports Differentiation of Pancreatic Endocrine Cells Mediated by a Negative Feed Back Regulation of Ngn3


Monday, February 27 | 8:00AM - 11:15AM
Moving from the Laboratory to Humans
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 5 of 7
Kai-Christian Sonntag, Harvard Medical School, USA
Embryonic Stem Cells as Cell Therapy for Parkinson’s Disease


Monday, February 27 | 8:00AM - 11:15AM
Moving from the Laboratory to Humans
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 6 of 7
Hsun Teresa Ku, Mount Sinai School of Medicine, USA
Short Talk: Insulin-Expressing Colonies Developed from Murine Embryonic Stem Cell-Derived Pancreatic beta-Cell Progenitors


Monday, February 27 | 8:00AM - 11:15AM
Moving from the Laboratory to Humans
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 7 of 7
Juan L. Contreras, University of Alabama at Birmingham, USA
Approaches to Improve Survival of Transplanted Islets


Monday, February 27 | 9:20AM - 9:40AM
Coffee Break
Room: Chamisa Lobby


Monday, February 27 | 4:30PM - 5:00PM
Coffee Available
Room: Chamisa Lobby


Monday, February 27 | 5:00PM - 7:15PM
Targets for Improving Beta Cell Function
Room: Chamisa Ballroom 1

Speaker 1 of 6
* Joseph Bryan, Pacific Northwest Research Institute, USA

Monday, February 27 | 5:00PM - 7:15PM
Targets for Improving Beta Cell Function
Room: Chamisa Ballroom 1

Speaker 2 of 6
Nancy A. Thornberry, Kallyope, Inc., USA
New Agents for the Treatment of Type 2 Diabetes

Monday, February 27 | 5:00PM - 7:15PM
Targets for Improving Beta Cell Function
Room: Chamisa Ballroom 1

Speaker 3 of 6
Rebecca A. Taub, VIA Pharmaceuticals, Inc, USA
Potential Novel Therapy for Type 2 Diabetes

Monday, February 27 | 5:00PM - 7:15PM
Targets for Improving Beta Cell Function
Room: Chamisa Ballroom 1

Speaker 4 of 6
Shinsaku Aramata, Nara Institute of Science and Technology, Japan
Short Talk: Synergistic Activation of the Insulin Promoter by the Beta-Cell Enriched Transcription Factors Mafa, Beta2, And Pdx1

Monday, February 27 | 5:00PM - 7:15PM
Targets for Improving Beta Cell Function
Room: Chamisa Ballroom 1

Speaker 5 of 6
Gary W. Cline, Yale University, USA
Short Talk: 13C Isotopomer Analysis of Impaired Insulin Secretion following siRNA Knockdown of Cytosolic and Mitochondrial Malic Enzyme Isoforms in INS-1 Cells

Monday, February 27 | 5:00PM - 7:15PM
Targets for Improving Beta Cell Function
Room: Chamisa Ballroom 1

Speaker 6 of 6
Claudia E. Robert, University of Pennsylvania, USA
Short Talk: Transgenic Mice Overexpressing the Novel Islet Specific Cytokine, PANDER, Exhibit Glucose Intolerance and Decreased beta Cell Mass

Monday, February 27 | 5:00PM - 7:15PM
Islet Proliferation, Growth and Survival
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 1 of 6
* † Fred Levine, Sanford-Burnham Medical Research Institute, USA


Monday, February 27 | 5:00PM - 7:15PM
Islet Proliferation, Growth and Survival
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 2 of 6
Marvin C. Gershengorn, National Institutes of Health, USA
Human Islet Precursors from Mature Islet Cells


Monday, February 27 | 5:00PM - 7:15PM
Islet Proliferation, Growth and Survival
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 3 of 6
Rennian Wang, University of Western Ontario, Canada
Short Talk: Temporal Gene Expression Patterns during Human Fetal Pancreas Development


Monday, February 27 | 5:00PM - 7:15PM
Islet Proliferation, Growth and Survival
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 4 of 6
Andrew F. Stewart, Mount Sinai School of Medicine, USA
Moleclar Control of Pancreatic B Cell Replication: Implications for Diabetes Therapy


Monday, February 27 | 5:00PM - 7:15PM
Islet Proliferation, Growth and Survival
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 5 of 6
Toshihiko Masui, University of Texas Southwestern Medical Center, USA
Short Talk: A Suppressor of Hairless is a Critical Component of the Pancreatic Acinar Complex PTF1 during Pancreatic Development


Monday, February 27 | 5:00PM - 7:15PM
Islet Proliferation, Growth and Survival
This session is from Pancreatic Islets
Room: Chamisa Ballroom 2

Speaker 6 of 6
Alvin C. Powers, Vanderbilt University School of Medicine, USA
Pancreatic Islets: Vascularization and Revascularization


Monday, February 27 | 7:15PM - 8:15PM
Social Hour
Room: Sagebrush Lounge


Monday, February 27 | 8:00PM - 11:00PM
Entertainment
Room: Chamisa Ballroom


Monday, February 27 | 8:15PM - 11:00PM
Cash Bar
Room: Chamisa Ballroom


Monday, February 27 | 8:15PM - 9:15PM
Dinner
Room: Chamisa Ballroom


Tuesday, February 28 | 10:26AM - 10:26AM
Departure


*Session Chair.