Web Desc
Nuclear Receptors: Steroid Sisters
joint with Nuclear Receptors: Orphan Brothers
Organizer(s): Carole R. Mendelson, Donald P. McDonnell and Malcolm G. Parker
Date: March 18 - 23, 2006
Location: Fairmont Banff Springs, Banff, AB, Canada
Supported by The Director's Fund
Summary of Meeting:
The overall goal of this conference is to provide the most important and up-to-date research in the nuclear receptor field. Topics presented will include the roles nuclear receptors in physiologic and pathophysiologic states, in development and in regulation of metabolic processes. Nuclear receptor-coregulator interactions, mechanisms in chromatin remodeling and transcriptional activation and repression also will be addressed, as will mechanisms of extranuclear signaling by steroid receptors. The roles of coregulators and nuclear receptors as potential targets for drug discovery will be considered, as well as structural properties of receptor domains complexed with ligands, cofactors, and DNA. It is our objective to highlight the latest biological tools (e.g., animal models, novel ligands, structural information) and technologies (e.g., genomics, proteomics, ligand screening) available for nuclear receptor research and promote the productive interaction of scientists from academic institutions and industry. The meeting venue also will facilitate the interaction of leading experts in the field with younger scientists and trainees, with a particular emphasis on the inclusion of underrepresented groups.
Scholarship Deadline: November 17 2005
Discounted Abstract Deadline: November 17 2005
Abstract Deadline: December 12 2005
Discounted Registration Deadline: January 18 2006
We gratefully acknowledge additional support for this conference from:
Invitrogen CorporationNovartis Institutes for BioMedical Research
We gratefully acknowledge the generous grant for this conference provided by:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Grant No. 1R13 DK074313-01
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

Click here to view more of these organizations

Program

Saturday, March 18 | 3:00PM - 7:30PM
Registration
Room: Van Horne Ballroom Foyer


Saturday, March 18 | 6:30PM - 7:30PM
Refreshments
Room: Van Horne Ballroom Foyer


Saturday, March 18 | 7:30PM - 8:30PM
Keynote Session (Joint)
Room: Van Horne Ballroom

Speaker 1 of 3
* Vincent Giguère, McGill University, Canada

Saturday, March 18 | 7:30PM - 8:30PM
Keynote Session (Joint)
Room: Van Horne Ballroom

Speaker 2 of 3
* Carole R. Mendelson, University of Texas Southwestern Medical Center, USA

Saturday, March 18 | 7:30PM - 8:30PM
Keynote Session (Joint)
Room: Van Horne Ballroom

Speaker 3 of 3
Elaine V. Fuchs, Rockefeller University, USA
Transcriptional Control of Stem Cells and Their Lineages

Sunday, March 19 | 7:00AM - 8:00AM
Breakfast
Room: New Brunswick, Alberta, Cascade


Sunday, March 19 | 8:00AM - 11:00AM
Steroid Receptors and Disease
Room: Van Horne Ballroom AB

Speaker 1 of 5
Carol A. Lange, University of Minnesota, USA
Integration of Progesterone Receptor and MAP Kinase Signaling in Breast Cancer Cell Models

Sunday, March 19 | 8:00AM - 11:00AM
Steroid Receptors and Disease
Room: Van Horne Ballroom AB

Speaker 2 of 5
* Benita S. Katzenellenbogen, University of Illinois, USA
Novel Modulators of Estrogen Receptor Function

Sunday, March 19 | 8:00AM - 11:00AM
Steroid Receptors and Disease
Room: Van Horne Ballroom AB

Speaker 3 of 5
Martin L. Privalsky, University of California, Davis, USA
Aberrant Thyroid Hormone Receptors: Mutations, Isoforms and Disease

Sunday, March 19 | 8:00AM - 11:00AM
Steroid Receptors and Disease
Room: Van Horne Ballroom AB

Speaker 4 of 5
Kenneth S. Korach, NIEHS, National Institutes of Health, USA
Differential Physiological Gene Responsiveness in ERKO Mice

Sunday, March 19 | 8:00AM - 11:00AM
Steroid Receptors and Disease
Room: Van Horne Ballroom AB

Speaker 5 of 5
Karen E. Knudsen, Thomas Jefferson University, Kimmel Cancer Center, USA
Short Talk: BRM ATPase Function in the Prostate: AR Regulation and Proliferative Control

Sunday, March 19 | 8:00AM - 11:00AM
Development and Differentiation
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne Ballroom C

Speaker 1 of 5
Sophia Y. Tsai, Baylor College of Medicine, USA
COUP-TFII in Development and Disease


Sunday, March 19 | 8:00AM - 11:00AM
Development and Differentiation
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne Ballroom C

Speaker 2 of 5
Thomas Perlmann, Karolinska Institutet, Ludwig Institute for Cancer Research, Sweden
Nurr1 and Other Factors in the Development and Stem Cell Engineering of Dopamine Neurons


Sunday, March 19 | 8:00AM - 11:00AM
Development and Differentiation
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne Ballroom C

Speaker 3 of 5
* Malcolm G. Parker, Imperial College London, UK
The Ups and Downs of Nuclear Receptor Action in Fat and Fertility


Sunday, March 19 | 8:00AM - 11:00AM
Development and Differentiation
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne Ballroom C

Speaker 4 of 5
Henry M. Krause, University of Toronto, Canada
Live Animal Screening for Nuclear Receptor Ligands


Sunday, March 19 | 8:00AM - 11:00AM
Development and Differentiation
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne Ballroom C

Speaker 5 of 5
Austin J. Cooney, Baylor College of Medicine, USA
Short Talk: Epigenetic Regulation of ES Cell Gene Repression by GCNF


Sunday, March 19 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Ballroom Foyer


Sunday, March 19 | 11:00AM - 1:00PM
Poster Setup
Room: New Brunswick, Alberta, Cascade


Sunday, March 19 | 1:00PM - 10:00PM
Poster Viewing
Room: New Brunswick, Alberta, Cascade


Sunday, March 19 | 3:30PM - 4:30PM
Hot Topics 1
Room: Van Horne AB

Speaker 1 of 5
* Nancy Lynn Weigel, Baylor College of Medicine, USA

Sunday, March 19 | 3:30PM - 4:30PM
Hot Topics 1
Room: Van Horne AB

Speaker 2 of 5
Mariam H. Al-Dhaheri, Medical University of Ohio, USA
Protein Kinase A (PKA)-Induced Ligand Independent Activity of Estrogen Receptor in Breast Cancer Cells is Accompanied by Decreased Estradiol Binding, Increased Association of ERalpha with HSP90 and Loss of Cell Viability

Sunday, March 19 | 3:30PM - 4:30PM
Hot Topics 1
Room: Van Horne AB

Speaker 3 of 5
James Thompson, University of Helsinki, Finland
Small Carboxyl-Terminal Domain Phosphatase 2 Knock-Down Increases RNA Polymerase II Phosphorylation and Androgen-Dependent Transcription in Prostate Cancer Cells

Sunday, March 19 | 3:30PM - 4:30PM
Hot Topics 1
Room: Van Horne AB

Speaker 4 of 5
Kirsten C. Fertuck, Dana Farber Cancer Institute, USA
Coactivation by AIB1 Contributes to Long-Range Association Between Proximal and Distal Estrogen Receptor Binding Sites in Breast Cancer Cells

Sunday, March 19 | 3:30PM - 4:30PM
Hot Topics 1
Room: Van Horne AB

Speaker 5 of 5
Frederic D. Flamant, Ecole Normale Superieure, France
Inducible Expression of a TRalpha Receptor with a AF2 Domain Mutation to Identify the Cell Autonomous Effects of Thyroid Hormone in Mouse Development and Homeostasis

Sunday, March 19 | 3:30PM - 4:30PM
Hot Topics 1
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne C

Speaker 1 of 5
* Carl S. Thummel, University of Utah School of Medicine, USA


Sunday, March 19 | 3:30PM - 4:30PM
Hot Topics 1
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne C

Speaker 2 of 5
Robert B. Beckstead, Howard Hughes Medical Institute, University of Utah, USA
Regulation of DHR78 Activity through a SAM-Domain Containing Corepressor, Moses


Sunday, March 19 | 3:30PM - 4:30PM
Hot Topics 1
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne C

Speaker 3 of 5
Carolyn L. Cummins, University of Toronto, Canada
LXR and Adrenal Cholesterol Homeostasis


Sunday, March 19 | 3:30PM - 4:30PM
Hot Topics 1
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne C

Speaker 4 of 5
William A. Alaynick, University of California, San Diego, The Salk Institute, USA
Loss of ERR3 Results in Cardiac Conduction Defects in Mouse


Sunday, March 19 | 3:30PM - 4:30PM
Hot Topics 1
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne C

Speaker 5 of 5
Daniel Malenfant, Centre de Recherche en Cancérologie de l'Université Laval, Canada
Genome-Wide Location Analysis of FTF/LRH-1 in Mouse Liver and Human Hepatoma Cells


Sunday, March 19 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Ballroom Foyer


Sunday, March 19 | 5:00PM - 7:00PM
Coregulators and Chromatin (Joint)
Room: Van Horne Ballroom

Speaker 1 of 4
* Ronald M. Evans, HHMI/The Salk Institute, USA

Sunday, March 19 | 5:00PM - 7:00PM
Coregulators and Chromatin (Joint)
Room: Van Horne Ballroom

Speaker 2 of 4
W. Lee Kraus, University of Texas Southwestern Medical Center, USA
Estrogen Signaling in the Nucleus: Role of Receptors, Coactivators, and Chromatin

Sunday, March 19 | 5:00PM - 7:00PM
Coregulators and Chromatin (Joint)
Room: Van Horne Ballroom

Speaker 3 of 4
Bert W. O'Malley, Baylor College of Medicine, USA
Birth to Death: Story of the SRC-3 Coactivator Complex

Sunday, March 19 | 5:00PM - 7:00PM
Coregulators and Chromatin (Joint)
Room: Van Horne Ballroom

Speaker 4 of 4
Michael G. Rosenfeld, University of California, San Diego, USA
Coregulatory Strategies Linking Nuclear Receptor Gene Activation Events and DNA Damage/Repair

Sunday, March 19 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: New Brunswick, Alberta, Cascade


Sunday, March 19 | 7:30PM - 10:00PM
Poster Session 1
Room: New Brunswick, Alberta, Cascade


Monday, March 20 | 7:00AM - 8:00AM
Breakfast
Room: New Brunswick, Alberta, Cascade


Monday, March 20 | 8:00AM - 11:00AM
Molecular Pharmacology of Steroid Receptors
Room: Van Horne Ballroom AB

Speaker 1 of 5
Geoffrey L. Greene, University of Chicago, USA
Structural Basis for Differential Responses of ERα and ERβ to Diverse Ligands

Monday, March 20 | 8:00AM - 11:00AM
Molecular Pharmacology of Steroid Receptors
Room: Van Horne Ballroom AB

Speaker 2 of 5
Dean P. Edwards, Baylor College of Medicine, USA
Transcriptional and Extra-nuclear Signaling Activities of the Progesterone Receptor Mediated by the Amino-terminal Domain.

Monday, March 20 | 8:00AM - 11:00AM
Molecular Pharmacology of Steroid Receptors
Room: Van Horne Ballroom AB

Speaker 3 of 5
Nancy Lynn Weigel, Baylor College of Medicine, USA
Regulation of Progesterone Receptor Action by Cycline Dependent Kinases

Monday, March 20 | 8:00AM - 11:00AM
Molecular Pharmacology of Steroid Receptors
Room: Van Horne Ballroom AB

Speaker 4 of 5
* Myles Brown, Dana-Farber Cancer Institute, USA
Genome-Wide Analysis of Steroid Receptor Function

Monday, March 20 | 8:00AM - 11:00AM
Molecular Pharmacology of Steroid Receptors
Room: Van Horne Ballroom AB

Speaker 5 of 5
Michael A. Mancini, Baylor College of Medicine, USA
Short Talk: Visualizing Nuclear Receptor Function at the Single Cell Level

Monday, March 20 | 8:00AM - 11:00AM
Metabolic Regulators and New Ligands
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne Ballroom C

Speaker 1 of 6
* David D. Moore, Baylor College of Medicine, USA


Monday, March 20 | 8:00AM - 11:00AM
Metabolic Regulators and New Ligands
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne Ballroom C

Speaker 2 of 6
Vincent Giguère, McGill University, Canada
Identification of ER and ERR-Driven Transcriptional Regulatory Networks: A Functional Genomic Approach to Uncover Nuclear Receptor Function in Physiology and Disease


Monday, March 20 | 8:00AM - 11:00AM
Metabolic Regulators and New Ligands
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne Ballroom C

Speaker 3 of 6
Anastasia Kralli, Johns Hopkins Medical School, USA
ERRa, A Regulator of Mitochondrial Function and Other PGC-1 Controlled Metabolic Pathways


Monday, March 20 | 8:00AM - 11:00AM
Metabolic Regulators and New Ligands
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne Ballroom C

Speaker 4 of 6
Beatrice Desvergne, University of Lausanne, Switzerland
Endocrine Disruptors Modulate PPAR Actions: A Live Study in the Living Cells


Monday, March 20 | 8:00AM - 11:00AM
Metabolic Regulators and New Ligands
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne Ballroom C

Speaker 5 of 6
Holly A. Ingraham, University of California, San Francisco, USA
NR5A Receptors in Neuroendocrine Physiology and in Female Reproductive Disease


Monday, March 20 | 8:00AM - 11:00AM
Metabolic Regulators and New Ligands
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne Ballroom C

Speaker 6 of 6
Janice Marie Huss, Beckman Research Institute at the City of Hope National Medical Center, USA
Short Talk: The Estrogen-Related Receptor alpha (ERRalpha) is Essential for Adaptive Cardiac Remodeling in Pressure Overload Models of Heart Failure


Monday, March 20 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Ballroom Foyer


Monday, March 20 | 11:00AM - 1:00PM
Poster Setup
Room: New Brunswick, Alberta, Cascade


Monday, March 20 | 1:00PM - 10:00PM
Poster Viewing
Room: New Brunswick, Alberta, Cascade


Monday, March 20 | 3:30PM - 4:30PM
Hot Topics 2
Room: Van Horne AB

Speaker 1 of 5
* John A. Cidlowski, NIEHS, National Institutes of Health, USA

Monday, March 20 | 3:30PM - 4:30PM
Hot Topics 2
Room: Van Horne AB

Speaker 2 of 5
Wen Cai, Karolinska Institute, Sweden
Crosstalk between Circadian System and Nuclear Receptors

Monday, March 20 | 3:30PM - 4:30PM
Hot Topics 2
Room: Van Horne AB

Speaker 3 of 5
Eliot Michael Bourk, University of California, San Diego, USA
An Evolutionarily Conserved Nuclear Receptor Sensor System Mediates Inflammatory Control of Estrogen-Repressed Genes

Monday, March 20 | 3:30PM - 4:30PM
Hot Topics 2
Room: Van Horne AB

Speaker 4 of 5
Daniel B. Hardy, Children's Health Research Institute, Lawson Health Research Institute, Canada
The Anti-Inflammatory Actions of the Progesterone Receptor (PR) May Exert a Protective Role in Breast Cancer

Monday, March 20 | 3:30PM - 4:30PM
Hot Topics 2
Room: Van Horne AB

Speaker 5 of 5
Atish Mukherjee, Baylor College of Medicine, USA
Ablation of SRC2 Coactivator Function in Murine Cell Lineages that Express the Progesterone Receptor Results in Severe Defects in the Female Reproductive System and Mammary Gland

Monday, March 20 | 3:30PM - 4:30PM
Hot Topics 2
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne C

Speaker 1 of 5
* Johan Auwerx, École Polytechnique Fédérale de Lausanne, Switzerland


Monday, March 20 | 3:30PM - 4:30PM
Hot Topics 2
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne C

Speaker 2 of 5
Marie Lagouge, Centre de recherche des Cordeliers U1138, France
The SIRT-1 Activator, Resveratrol, Induces Weight Loss through Increasing Basal Energy Expenditure


Monday, March 20 | 3:30PM - 4:30PM
Hot Topics 2
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne C

Speaker 3 of 5
Junichiro Sonoda, Regeneron Pharmaceuticals, Inc., USA
Metabolic Activation of Macrophage Function by ERRalpha


Monday, March 20 | 3:30PM - 4:30PM
Hot Topics 2
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne C

Speaker 4 of 5
Y. Lynn Wang, Weill Medical College of Cornell University, USA
PPARgamma Promotes Cell Survival through Its Actions on Cellular Metabolic Activities


Monday, March 20 | 3:30PM - 4:30PM
Hot Topics 2
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne C

Speaker 5 of 5
Mercedes Ricote, Centro Nacional de Investigaciones Cardiovasculares, Spain
Macrophage Specific PPAR-gamma Gene Deletion Causes Whole Body Insulin Resistance and Glucose Intolerance


Monday, March 20 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Ballroom Foyer


Monday, March 20 | 5:00PM - 7:00PM
Nuclear Receptors and Metabolism (Joint)
Room: Van Horne Ballroom

Speaker 1 of 4
* Vincent Giguère, McGill University, Canada

Monday, March 20 | 5:00PM - 7:00PM
Nuclear Receptors and Metabolism (Joint)
Room: Van Horne Ballroom

Speaker 2 of 4
David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA
Ligand-dependent Regulation of Metabolism and Reproduction: Evolution of the Nuclear Receptor Paradigm

Monday, March 20 | 5:00PM - 7:00PM
Nuclear Receptors and Metabolism (Joint)
Room: Van Horne Ballroom

Speaker 3 of 4
Ronald M. Evans, HHMI/The Salk Institute, USA
PPARd at the Crossroads of Inflammation and Metabolism

Monday, March 20 | 5:00PM - 7:00PM
Nuclear Receptors and Metabolism (Joint)
Room: Van Horne Ballroom

Speaker 4 of 4
Bruce M. Spiegelman, Harvard Medical School, USA
PGC-1 Coactivators and the Control of Energy Homeostasis

Monday, March 20 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: New Brunswick, Alberta, Cascade


Monday, March 20 | 7:30PM - 10:00PM
Poster Session 2
Room: New Brunswick, Alberta, Cascade


Tuesday, March 21 | 7:00AM - 8:00AM
Breakfast
Room: New Brunswick, Alberta, Cascade


Tuesday, March 21 | 8:00AM - 11:00AM
Steroid Receptors and Chromatin
Room: Van Horne Ballroom AB

Speaker 1 of 4
* Michael R. Stallcup, University of Southern California, USA
The p160 Coactivator Signaling Pathway: Roles of Secondary Coactivators and Protein Methylation in Transcriptional Regulation

Tuesday, March 21 | 8:00AM - 11:00AM
Steroid Receptors and Chromatin
Room: Van Horne Ballroom AB

Speaker 2 of 4
Jiemin Wong, Baylor College of Medicine, USA
Function of Androgen Receptor in Chromatin

Tuesday, March 21 | 8:00AM - 11:00AM
Steroid Receptors and Chromatin
Room: Van Horne Ballroom AB

Speaker 3 of 4
Catherine C. Thompson, Pfizer, USA
Linking Corepressor Action and Wnt Signaling: Epithelial Stem Cell Differentiation

Tuesday, March 21 | 8:00AM - 11:00AM
Steroid Receptors and Chromatin
Room: Van Horne Ballroom AB

Speaker 4 of 4
Carolyn L. Smith, Baylor College of Medicine, USA
Short Talk: Corepressor Contribution to Activation of Estrogen Receptor-a-Dependent Gene Expression

Tuesday, March 21 | 8:00AM - 11:00AM
Immune System
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne Ballroom C

Speaker 1 of 6
* Christopher K. Glass, University of California, San Diego, USA


Tuesday, March 21 | 8:00AM - 11:00AM
Immune System
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne Ballroom C

Speaker 2 of 6
Xiao-Kun Zhang, Sanford-Burnham Medical Research Institute, USA
The Nur77-Bcl-2 apoptotic pathway in cancer cells.


Tuesday, March 21 | 8:00AM - 11:00AM
Immune System
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne Ballroom C

Speaker 3 of 6
Dan R. Littman, HHMI/New York University School of Medicine, USA
Role of ROR?t in Development and Homeostasis of the Immune System



Tuesday, March 21 | 8:00AM - 11:00AM
Immune System
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne Ballroom C

Speaker 4 of 6
Peter Tontonoz, University of California, Los Angeles, USA
Nuclear Receptors, Metabolism and Inflammation


Tuesday, March 21 | 8:00AM - 11:00AM
Immune System
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne Ballroom C

Speaker 5 of 6
† Timothy M. Willson, GlaxoSmithKline, USA
Structure-Guided Design of Anti-Inflammatory LXR Modulators


Tuesday, March 21 | 8:00AM - 11:00AM
Immune System
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne Ballroom C

Speaker 6 of 6
Ajay Chawla, Merck Research Labs, USA
Short Talk: Transcriptional Crosstalk between Metabolism and Inflammation


Tuesday, March 21 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Ballroom Foyer


Tuesday, March 21 | 11:00AM - 1:00PM
Poster Setup
Room: New Brunswick, Alberta, Cascade


Tuesday, March 21 | 1:00PM - 10:00PM
Poster Viewing
Room: New Brunswick, Alberta, Cascade


Tuesday, March 21 | 3:30PM - 4:30PM
Hot Topics 3
Room: Van Horne AB

Speaker 1 of 5
* Carolyn L. Smith, Baylor College of Medicine, USA

Tuesday, March 21 | 3:30PM - 4:30PM
Hot Topics 3
Room: Van Horne AB

Speaker 2 of 5
Didier Auboeuf, Institut Universitaire d'hématologie/ Hôpital Saint Louis, France
Control of the Synthesis and the Fate of Gene Transcripts by Transcriptional Coregulators

Tuesday, March 21 | 3:30PM - 4:30PM
Hot Topics 3
Room: Van Horne AB

Speaker 3 of 5
Sung Hee Baek, Seoul National University, South Korea
Roles of Nuclear Receptor Coregulators and their Modification Codes in Regulation of a Metastasis Suppressor Gene

Tuesday, March 21 | 3:30PM - 4:30PM
Hot Topics 3
Room: Van Horne AB

Speaker 4 of 5
Suzanne E. Wardell, Duke University Medical Center, USA
Circumventing Glucocorticoid Resistance in Multiple Myeloma Using Histone Deacetylase Inhibitors to Down-Regulate Growth Factor Receptor Expression

Tuesday, March 21 | 3:30PM - 4:30PM
Hot Topics 3
Room: Van Horne AB

Speaker 5 of 5
Shane M. Colley, Western Australian Institute for Medical Research, Australia
Characterization of Four Novel SRA-Binding Coregulators that Modulate Nuclear Receptor Signaling in Cancer

Tuesday, March 21 | 3:30PM - 4:30PM
Hot Topics 3
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne C

Speaker 1 of 4
Kendall W. Nettles, The Scripps Research Institute, USA
Structural Features of the Phantom Ligand Effect in RXR Heterodimers


Tuesday, March 21 | 3:30PM - 4:30PM
Hot Topics 3
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne C

Speaker 2 of 4
Ines Pineda-Torra, University College London, UK
Phosphorylation of LXRalpha Reprograms Target Gene Expression in Macrophages


Tuesday, March 21 | 3:30PM - 4:30PM
Hot Topics 3
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne C

Speaker 3 of 4
* Frances M. Sladek, University of California, Riverside, USA
Phosphorylation of a Conserved Serine in the Nuclear Receptor DNA Binding Domain Stimulates Nuclear Export


Tuesday, March 21 | 3:30PM - 4:30PM
Hot Topics 3
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne C

Speaker 4 of 4
Susanne Mandrup, University of Southern Denmark, Denmark
PPAR Subtype Specific Activation of Genomic Target Genes in Hepatocytes upon Adenoviral Transgene Delivery


Tuesday, March 21 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Ballroom Foyer


Tuesday, March 21 | 5:00PM - 7:00PM
Transcriptional Control Mechanisms (Joint)
Room: Van Horne Ballroom

Speaker 1 of 4
* Bert W. O'Malley, Baylor College of Medicine, USA

Tuesday, March 21 | 5:00PM - 7:00PM
Transcriptional Control Mechanisms (Joint)
Room: Van Horne Ballroom

Speaker 2 of 4
Christopher K. Glass, University of California, San Diego, USA
Mechanisms Mediating Anti-Inflammatory Activities of Nuclear Receptors

Tuesday, March 21 | 5:00PM - 7:00PM
Transcriptional Control Mechanisms (Joint)
Room: Van Horne Ballroom

Speaker 3 of 4
Pierre H. Chambon, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), France
Genetic and pharmacological dissection of the (patho)physiological function of RXR/Nuclear Receptor heterodimers in epidermal keratinocytes of the mouse skin

Tuesday, March 21 | 5:00PM - 7:00PM
Transcriptional Control Mechanisms (Joint)
Room: Van Horne Ballroom

Speaker 4 of 4
Mitchell A. Lazar, Perelman School of Medicine, University of Pennsylvania, USA
The Ups and Downs of Repression

Tuesday, March 21 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: New Brunswick, Alberta, Cascade


Tuesday, March 21 | 7:30PM - 10:00PM
Poster Session 3
Room: New Brunswick, Alberta, Cascade


Wednesday, March 22 | 7:00AM - 8:00AM
Breakfast
Room: New Brunswick, Alberta, Cascade


Wednesday, March 22 | 8:00AM - 11:00AM
Steroid Receptor Biology
Room: Van Horne Ballroom AB

Speaker 1 of 5
Jan-Åke Gustafsson, University of Houston, USA
Biology of estrogen receptor beta - New Insights

Wednesday, March 22 | 8:00AM - 11:00AM
Steroid Receptor Biology
Room: Van Horne Ballroom AB

Speaker 2 of 5
* Keith R. Yamamoto, University of California, San Francisco, USA
GR Ligands Differentially Modulate GR:GRE Occupancy or GR Regulatory Activity

Wednesday, March 22 | 8:00AM - 11:00AM
Steroid Receptor Biology
Room: Van Horne Ballroom AB

Speaker 3 of 5
John A. Cidlowski, NIEHS, National Institutes of Health, USA
The Glucocorticoid Receptor: One Gene, Many Proteins, Extensive Post Translational Modifications: Mechanisms for Tissue Specific Anti-inflammatory Actions

Wednesday, March 22 | 8:00AM - 11:00AM
Steroid Receptor Biology
Room: Van Horne Ballroom AB

Speaker 4 of 5
Carole R. Mendelson, University of Texas Southwestern Medical Center, USA
Mechanisms in the Decline of Progesterone Receptor Function Leading to Parturition

Wednesday, March 22 | 8:00AM - 11:00AM
Steroid Receptor Biology
Room: Van Horne Ballroom AB

Speaker 5 of 5
Inez Rogatsky, Weill Medical College of Cornell University, USA
Short Talk: The GRIP1:IRF3 Interaction as a Target for Glucocorticoid Receptor-Mediated Immunosuppression

Wednesday, March 22 | 8:00AM - 11:00AM
Physiology and Cancer
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne Ballroom C

Speaker 1 of 6
* Anastasia Kralli, Johns Hopkins Medical School, USA


Wednesday, March 22 | 8:00AM - 11:00AM
Physiology and Cancer
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne Ballroom C

Speaker 2 of 6
Carlie J. M. de Vries, University of Amsterdam, Netherlands
Nur77-Like Nuclear Receptors in Atherosclerosis


Wednesday, March 22 | 8:00AM - 11:00AM
Physiology and Cancer
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne Ballroom C

Speaker 3 of 6
David D. Moore, Baylor College of Medicine, USA
Nuclear Receptors and Liver Regeneration


Wednesday, March 22 | 8:00AM - 11:00AM
Physiology and Cancer
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne Ballroom C

Speaker 4 of 6
Joyce J. Repa, University of Texas Southwestern Medical Center, USA
LXR-mediated Regulation of Glucose and Lipid Metabolism.


Wednesday, March 22 | 8:00AM - 11:00AM
Physiology and Cancer
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne Ballroom C

Speaker 5 of 6
Jacques Drouin, Institut de Recherches Cliniques de Montréal, Canada
NGFIB and GR: Molecular Pathogenesis of Glucocorticoid Resistance in Cushing’s Disease


Wednesday, March 22 | 8:00AM - 11:00AM
Physiology and Cancer
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne Ballroom C

Speaker 6 of 6
Richard A. Heyman, ORIC Pharmaceuticals, USA
Short Talk


Wednesday, March 22 | 9:20AM - 9:40AM
Coffee Break
Room: Van Horne Ballroom Foyer


Wednesday, March 22 | 3:30PM - 4:30PM
Hot Topics 4
Room: Van Horne AB

Speaker 1 of 4
* Kenneth S. Korach, NIEHS, National Institutes of Health, USA

Wednesday, March 22 | 3:30PM - 4:30PM
Hot Topics 4
Room: Van Horne AB

Speaker 2 of 4
Kerstin W. Sinkevicius, Children's Hospital Boston, USA
Estrogen Receptor Alpha G525L Knock-In Mice

Wednesday, March 22 | 3:30PM - 4:30PM
Hot Topics 4
Room: Van Horne AB

Speaker 3 of 4
Jan P. Tuckermann, Leibniz Institute for Age Research - Fritz Lipmann Institute, Germany
Glucocorticoid induced Osteoporosis requires the Glucocorticoid Receptor in Osteoblasts and does not Depend on DNA Binding of the Receptor

Wednesday, March 22 | 3:30PM - 4:30PM
Hot Topics 4
Room: Van Horne AB

Speaker 4 of 4
Eriko Matsuura, University of Tokyo, Japan
E2F Transcriptional Activation as a Potential Mechanism of Neurodegeneration of Polyglutamine Expansion Androgen Receptor Mutants

Wednesday, March 22 | 3:30PM - 4:30PM
Hot Topics 4
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne C

Speaker 1 of 5
* Ming-Jer Tsai, Baylor College of Medicine, USA


Wednesday, March 22 | 3:30PM - 4:30PM
Hot Topics 4
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne C

Speaker 2 of 5
Xin Xie, Baylor College of Medicine, USA
The Orphan Nuclear Receptor COUP-TFII Plays an Important Role in Adipogenesis


Wednesday, March 22 | 3:30PM - 4:30PM
Hot Topics 4
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne C

Speaker 3 of 5
Takeshi Inagaki, University of Tokyo, Japan
Regulation of Mucosal Defense in Intestine by the Nuclear Bile Acid Receptor


Wednesday, March 22 | 3:30PM - 4:30PM
Hot Topics 4
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne C

Speaker 4 of 5
Grace L. Guo, Rutgers University, USA
Role of the Farnesoid X Receptor in Foam-Cell Formation and Atherosclerosis Development


Wednesday, March 22 | 3:30PM - 4:30PM
Hot Topics 4
This session is from Nuclear Receptors: Orphan Bro
Room: Van Horne C

Speaker 5 of 5
Liming Pei, Children's Hospital of Philadelphia/University of Pennsylvania, USA
NR4A Orphan Nuclear Receptors Regulate Hepatic Glucose Metabolism in Fasting and Diabetes


Wednesday, March 22 | 4:30PM - 5:00PM
Coffee Available
Room: Van Horne Ballroom Foyer


Wednesday, March 22 | 5:00PM - 7:00PM
Nuclear Receptors and Biological Function (Joint), Supported
by Invitrogen Corporation

Room: Van Horne Ballroom

Speaker 1 of 3
* Carole R. Mendelson, University of Texas Southwestern Medical Center, USA

Wednesday, March 22 | 5:00PM - 7:00PM
Nuclear Receptors and Biological Function (Joint), Supported
by Invitrogen Corporation

Room: Van Horne Ballroom

Speaker 2 of 3
Donald P. McDonnell, Duke University School of Medicine, USA
The Biological Consequences of Differential Receptor-Cofactor Interactions

Wednesday, March 22 | 5:00PM - 7:00PM
Nuclear Receptors and Biological Function (Joint), Supported
by Invitrogen Corporation

Room: Van Horne Ballroom

Speaker 3 of 3
Johan Auwerx, École Polytechnique Fédérale de Lausanne, Switzerland
French Women Don't Get Fat

Wednesday, March 22 | 7:00PM - 8:00PM
Social Hour with Lite Bites
Room: New Brunswick, Alberta, Cascade


Wednesday, March 22 | 8:00PM - 11:00PM
Entertainment
Room: New Brunswick, Alberta, Cascade


Wednesday, March 22 | 8:00PM - 11:00PM
Cash Bar
Room: New Brunswick, Alberta, Cascade


Thursday, March 23 | 10:26AM - 10:26AM
Departure


*Session Chair.